793 results match your criteria Ovary Dysgerminoma


Ovarian dysgerminoma with pseudo-Meigs syndrome: A case report.

Medicine (Baltimore) 2021 Jun;100(23):e26319

Forensic and Pathology Laboratory, Jiaxing University Medical College, Jiaxing, ZJ, China.

Rationale: Dysgerminoma is a rare malignant tumor of the ovary, more frequently occurring in young women. The main signs of pseudo-Meigs syndrome (PMS) are ascites and hydrothorax accompanying benign or malignant ovarian tumors (no fibroma or fibroma-like tumor).

Patient Concerns: A 19-year-old woman with fever and chest tightness for 2 days. Read More

View Article and Full-Text PDF

Dysgerminoma of the ovary in a patient with triple-X syndrome (47, XXX) and Marfanoid habitus features.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Department of Gynecology, Gynecologic Oncology and Gynecologic Endocrinology, Medical University of Gdansk, Poland.

View Article and Full-Text PDF

Comparison of immunohistochemical profiles of ovarian germ cells in dysgerminomas of a captive maned wolf and domestic dogs.

J Vet Diagn Invest 2021 May 28:10406387211019959. Epub 2021 May 28.

Setor de Patologia Veterinária, Departamento de Patologia Clínica Veterinária, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

We characterized the immunohistochemical expression profiles of dysgerminomas from a 16-y-old maned wolf and 13 domestic dogs using the following biomarkers: Sal-like protein 4 (SALL4), octamer-binding transcription factor 3/4 (OCT3/4), placental alkaline phosphatase (PLAP), c-kit, and vimentin. The maned wolf had nonspecific and long-standing clinical signs of lethargy, anorexia, and weight loss, and was euthanized because of poor prognosis. At autopsy, the left ovary was effaced by a 12 × 8 × 6 cm mass, comprised of anaplastic cells with a mitotic count of 20 mitoses in 10 high power fields. Read More

View Article and Full-Text PDF

Ovarian Dysgerminoma in Pregnant Women with Viable Fetus: A Rare Case Report.

Case Rep Oncol 2021 Jan-Apr;14(1):141-146. Epub 2021 Mar 1.

Hematopathology Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar.

Dysgerminoma is an uncommon malignant tumor arising from the germ cells of the ovary. Its association with pregnancy is extremely rare, with a reported incidence of about 0.2-1 per 100,000 pregnancies. Read More

View Article and Full-Text PDF

Dysgerminoma of the Ovary: An Analysis of 140 Cases Emphasizing Unusual Microscopic Findings and Resultant Diagnostic Problems.

Am J Surg Pathol 2021 Feb 9. Epub 2021 Feb 9.

James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

One-hundred fourty pure dysgerminomas were evaluated with particular focus on the microscopic features as seen in 125 cases with available slides. The patients ranged from 8 to 59 years of age (mean, 24.1 y). Read More

View Article and Full-Text PDF
February 2021

Malignant Mixed Germ Cell Tumors of the Ovary: An Analysis of 100 Cases Emphasizing the Frequency and Interrelationships of Their Tumor Types.

Am J Surg Pathol 2021 Jun;45(6):727-741

James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

One hundred malignant mixed germ cell tumors of the ovary that occurred in patients 3 to 55 years (mean: 20 y) of age are described. The clinical presentation was usually that of any highly malignant tumor of the ovary (abdominal pain and distension), but rarely (3 cases) endocrine manifestations were present. The tumors were usually unilateral (96%), ranged from 4 to 38 cm (mean: 16 cm), and were uniformly solid or, more often, solid and cystic; occasionally the typical appearance of dysgerminoma could be appreciated. Read More

View Article and Full-Text PDF

Ovarian dysgerminoma detected by 18F-FDG PET/CT technique: A case report.

Medicine (Baltimore) 2020 Nov;99(45):e23074

Department of Pathology, Yichang Central People's Hospital, China Three Gorges University, Yichang, PR China.

Introduction: Ovarian dysgerminoma (OD) mostly affect young women, have a rapid growth rate, and could result in complications such as rupture, hemoperitoneum or torsion, and acute abdomen. However, there have been no reports of OD on F-FDG PET/CT imaging.

Patient Concerns: A 21-year-old female patient was admitted to our hospital on February 6, 2016, due to "reduced menstrual flow with abdominal distension for 3 months". Read More

View Article and Full-Text PDF
November 2020

Ovarian Diffuse Large B-cell Lymphoma Initially Suspected Dysgerminoma Managed by Laparoscopic Staging Surgery.

Gynecol Minim Invasive Ther 2020 Jul-Sep;9(3):162-165. Epub 2020 May 9.

Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan.

Ovarian diffuse large B-cell lymphoma (DLBCL) is rare. DLBCL is a complex type of lymphoma. The ovarian DLBCL usually harbor a favorable prognosis. Read More

View Article and Full-Text PDF

Pregnancy with giant ovarian dysgerminoma: A case report and literature review.

Medicine (Baltimore) 2020 Oct;99(41):e21214

Department of Gynecology.

Rationale: Dysgerminoma is an extraordinarily rare neoplasm arising from the malignant germ cells of the ovary. Early antenatal diagnosis and proper management of the neoplasm to improve maternal-neonatal results are the considerable challenges facing the gyne-oncologist. We summarize the clinical features and discuss treatment strategies of the ovary dysgerminoma (OD). Read More

View Article and Full-Text PDF
October 2020

Pure dysgerminoma of the ovary: CT and MRI features with pathological correlation in 13 tumors.

J Ovarian Res 2020 Jun 17;13(1):71. Epub 2020 Jun 17.

Department of Radiology, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.

Background: To investigate the spectrum of CT and MRI findings of dysgerminoma of the ovary.

Methods: CT and MRI imaging of 12 patients with 13 histologically proven dysgerminomas of the ovary were retrospectively reviewed. Patients ages ranged from 6 ~ 27 years (mean, 17. Read More

View Article and Full-Text PDF

[Management of intra-abdominal dysgerminoma During pregnancy - A Case Report and Literature Review].

Z Geburtshilfe Neonatol 2020 Oct 2;224(5):306-314. Epub 2020 Apr 2.

Schwerpunkt Geburtshilfe, Krankenhaus Barmherzige Brüder Regensburg, Frauenklinik Sankt Hedwig, Regensburg.

Introduction: Dysgerminomas are rare malignant germ cell tumors. They usually arise from the ovary, but case reports describing extraovarian dysgerminomas do exist. When treated adequately the disease has a good prognosis. Read More

View Article and Full-Text PDF
October 2020

Role of staging surgery and adjuvant chemotherapy in adult patients with apparent stage I pure immature ovarian teratoma after fertility-sparing surgery.

Int J Gynecol Cancer 2020 05 15;30(5):664-669. Epub 2020 Mar 15.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

Objective: The standard treatment for young patients with stage I malignant ovarian germ cell tumors, except stage I dysgerminoma and stage IA G1 immature teratoma, is unilateral salpingo-oophorectomy with complete staging surgery followed by platinum-based chemotherapy. However, the role of complete staging surgery and adjuvant chemotherapy remains controversial. The aim of this study was to investigate the role of complete staging surgery and adjuvant chemotherapy in patients with early-stage pure immature teratoma after fertility-sparing surgery. Read More

View Article and Full-Text PDF

Trends in the surgical management of malignant ovarian germcell tumors.

Gynecol Oncol 2020 04 31;157(1):89-93. Epub 2020 Jan 31.

Division of Gynecologic Oncology, University of Pennsylvania Health System, Philadelphia, PA, USA.

Objective: To evaluate trends in the surgical management of young women and pediatric patients with malignant ovarian germ cell tumors (MOGCTs) and associated survival outcomes.

Materials And Methods: Using the Surveillance, Epidemiology, and End Results database we identified patients under 40 years who underwent surgery between 1994 and 2014. The Joinpoint Regression Program was employed to investigate the presence of temporal trends and calculate average annual percent change (AAPC) rates. Read More

View Article and Full-Text PDF

Malignant Mixed Germ Cell Tumors of the Ovary: A Series of Rare Cases.

J Reprod Infertil 2019 Oct-Dec;20(4):231-236

Department of Pathology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.

Background: Malignant mixed germ cell tumors of ovary are rare aggressive cancers affecting young adolescent girls. The commonest combination reported in literature is dysgerminoma and endodermal sinus tumors but in our study the most common combination was immature teratoma and endodermal sinus tumor which is exteremely rare. Preservation of future fertility is a concern. Read More

View Article and Full-Text PDF
January 2020

Ovarian germ cell tumour classification: views from the testis.

Histopathology 2020 Jan;76(1):25-36

Centre for Molecular Oncology, Barts Cancer Institute, Charterhouse Square, Queen Mary University of London, London, UK.

The classification of ovarian germ cell tumours has remained unchanged for many years, while there have been considerable changes in the testicular classification. In recent years there has been concern about the overtreatment of clinical stage 1 testicular germ cell tumours with increasing use of surveillance for low-risk disease. We outline here the current classification of germ cell tumours of the ovary with particular regard to treatment and outcome and highlight some areas which may cause confusion, particularly pertaining to immature teratomas and mixed germ cell tumours. Read More

View Article and Full-Text PDF
January 2020

Malignant Lymphoma of the Ovary: A Diagnostic Pitfall of Intraoperative Consultation.

Int J Gynecol Pathol 2020 Jan;39(1):79-83

Primary ovarian lymphomas are rare, but can potentially evoke diagnostic problems. We present a case of ovarian lymphoma, in which an ambiguous intraoperative pathologic report led to overtreatment (unnecessary surgery). A 73-yr-old woman with fatigue and low-grade fever was diagnosed as having a left ovarian tumor by imaging modalities. Read More

View Article and Full-Text PDF
January 2020

What is your diagnosis? Coelomic effusion in a skittering frog.

Vet Clin Pathol 2020 Mar 27;49(1):158-160. Epub 2019 Nov 27.

Department of Biomedical Engineering and Mechanics, Virginia Tech University, Blacksburg, VA, USA.

View Article and Full-Text PDF

Canine ovarian gonadoblastoma with dysgerminoma overgrowth: a case study and literature review.

J Ovarian Res 2019 Sep 23;12(1):89. Epub 2019 Sep 23.

Department of Pathology and Molecular Immunology of the Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua Jorge Viterbo Ferreira nr.228, 4050-313, Porto, Portugal.

Background: Gonadoblastoma (GB) is a rare mixed germ cell-sex cord-stromal tumour, first described in humans, commonly found in dysgenetic gonads of intersex patients that have a Y chromosome. However, this entity in not recognized in the WHO classification of tumours of genital system of domestic animals. Herein, we describe a case of ovarian gonadoblastoma with proliferation of dysgerminoma and sex cord-stromal tumour components, in a phenotypically and cytogenetically normal bitch. Read More

View Article and Full-Text PDF
September 2019

Genetic Causes of Rare Pediatric Ovarian Tumors.

Klin Onkol 2019 ;32(Supplementum2):79-91

Background: Ovarian tumors in childhood and adolescence are distinguished from those that arise in adulthood by their histological subtype. These tumors may arise as the first manifestation of a cancer predisposition syndrome. Correct diagnosis of the syndrome may offer the possibility of surveillance for other members of the patients family. Read More

View Article and Full-Text PDF
January 2020

Germ Cell Tumors of the Female Genital Tract.

Surg Pathol Clin 2019 Jun;12(2):621-649

Department of Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard Unit 85, Houston, TX 77030, USA. Electronic address:

Ovarian germ cell tumors are a histologically diverse group of neoplasms with a common origin in the primitive germ cell. The vast majority are represented by mature cystic teratoma. In the minority are malignant germ cell tumors including immature teratoma, dysgerminoma, yolk sac tumor, embryonal cell carcinoma, and choriocarcinoma. Read More

View Article and Full-Text PDF

Prognostic significance of residual disease in advanced stage malignant ovarian germ cell tumors.

Int J Gynecol Cancer 2019 03 29;29(3):554-559. Epub 2019 Jan 29.

Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York City, New York, USA.

Objective: To investigate the prognostic significance of complete gross resection following cytoreductive surgery for patients with advanced stage malignant ovarian germ cell tumors.

Methods: The National Cancer Data Base was accessed and patients diagnosed with an advanced stage (II-IV) malignant ovarian germ cell tumor who underwent primary cytoreductive surgery between 2011 and 2014 were selected for further analysis. For analysis purposes two groups were formed: patients with complete gross resection and those with macroscopic residual disease. Read More

View Article and Full-Text PDF

'Size does matter': Prophylactic gonadectomy in a case of Swyer syndrome.

J Gynecol Obstet Hum Reprod 2019 Apr 25;48(4):283-286. Epub 2019 Jan 25.

Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Swyer syndrome also known as pure or complete gonadal dysgenesis is a very rare disorder of sex development wherein the individuals are phenotypically females with 46, XY genotype and preserved mullerian structures. These individuals characteristically have dysgenetic streak gonads which carry an increased risk of malignant transformation. Prophylactic gonadectomy is highly recommended as soon as a clinical diagnosis is established to diminish the chances of tumor development. Read More

View Article and Full-Text PDF

Prognostic Impact of Lymphadenectomy in Different Stages of Malignant Germ Cell Tumor of the Ovary Based on Propensity Score Matching.

Comb Chem High Throughput Screen 2018 ;21(9):652-661

Department of Gynecology and Obstetrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Background: Lymphadenectomy has been widely used in the treatment of malignant germ cell tumor of the ovary (OGCT), which is a kind of ovarian cancers occurred mostly in young women and adolescent girls. But the clinical decision mainly depends on the doctor's experience without a well-defined guideline. This population-based study aimed to evaluate the prognostic impact of lymphadenectomy in different stages of malignant germ cell tumors of the ovary. Read More

View Article and Full-Text PDF

Pitfalls of Frozen Section in Gynecological Pathology: A Rare Case of Ovarian Lymphoma in an HIV-Positive Woman Resembling Dysgerminoma on Frozen Section.

Int J Surg Pathol 2019 Jun 25;27(4):387-389. Epub 2018 Nov 25.

1 Rutgers-New Jersey Medical School, Newark, NJ, USA.

Primary lymphoma of the ovary, particularly in an HIV-positive woman, is exceptionally rare, and ovarian lymphoma may not be considered at the time of intraoperative consultation. In this article, we present a case in an HIV-positive woman thought to be a dysgerminoma at the time of frozen section, but which was found to be a diffuse large B-cell lymphoma of the ovary. Read More

View Article and Full-Text PDF

Pediatric ovarian dysgerminoma with highly elevated serum neuron-specific enolase.

Pediatr Int 2018 Oct;60(10):982-983

Department of Pediatrics, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

View Article and Full-Text PDF
October 2018

Treatment of bilateral ovarian dysgerminoma with 11-year follow-up: A case report.

Ann Med Surg (Lond) 2018 Sep 21;33:50-52. Epub 2018 Aug 21.

Faculdade de Medicina (FAMED) - Universidade Federal do Rio Grande (FURG), Rio Grande city, Rio Grande do Sul State, Brazil.

Introduction: Malignant ovarian germ cell tumors (MOGCTs) are rare malignancies with an incidence of about 0.5/100,000. They account for less than 5% of all ovarian tumors, of which 32. Read More

View Article and Full-Text PDF
September 2018

[Pathologic features on gonadal changes of sexual developmental disorders in children].

Zhonghua Bing Li Xue Za Zhi 2018 Jul;47(7):531-535

Department of Pediatric Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.

To investigate the pathologic features of gonadal tissues of disorders of sexual development (DSD) in children. Fifty-three cases of gonadal developmental disorders were collected from July 2015 to August 2017 at Guangzhou Women and Children's Medical Center. Clinical manifestations, karyotypes, sex hormone levels, ultrasound imaging, histology and immunophenotype of gonadal tissues were analyzed. Read More

View Article and Full-Text PDF

Torsion of Ovarian Dysgerminoma in a Child: Role of Computed Tomography.

Cureus 2018 Apr 23;10(4):e2522. Epub 2018 Apr 23.

Department of Pathology & Laboratory Medicine, The Aga Khan University, Karachi, PAK.

Dysgerminomas are malignant germ cell tumors of the ovary that most commonly occur in the adolescent population. Ovarian dysgerminoma presenting with complications like torsion is a rare entity in the pediatric age group. Cross-sectional imaging plays a crucial role in diagnosis, tumor staging before surgical resection, and for planning adjuvant chemotherapy. Read More

View Article and Full-Text PDF

Germ Cell Tumor Ovary: an Institutional Experience of Treatment and Survival Outcomes.

Indian J Surg Oncol 2018 Jun 10;9(2):215-219. Epub 2018 Apr 10.

1Department of Surgical Oncology, King George's Medical University, Lucknow, Uttar Pradesh 226003 India.

Malignant germ cell tumors (GCT) of the ovary account for 2-3% of all ovarian neoplasms and occur mostly in the second and third decade of life. Over the past three decades, survival rates for germ cell tumors have dramatically improved, coincident with more aggressive surgical staging and combination chemotherapy. Although there are several studies describing ovarian GCT and fertility-preserving surgery in the western population, there is very little Indian data. Read More

View Article and Full-Text PDF

Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults?

Gynecol Oncol 2018 08 5;150(2):253-260. Epub 2018 Jun 5.

Children's and Young Persons Cancer Services, University College London Hospital Trusts, London, UK.

Objective: Dysgerminoma is the most common malignant ovarian germ cell tumor (GCT) with peak incidence during adolescence and young adulthood. Current standard of care for patients with disease that has spread outside of the ovary (advanced-stage) utilizes platin-based chemotherapy regimens. The study objective was to compare clinical outcomes between platin-based (carboplatin versus cisplatin) strategies across all age groups (children < 11 years (y), adolescents = 11-25 y and young adult women > 25 y) for advanced-stage dysgerminoma. Read More

View Article and Full-Text PDF