781 results match your criteria Ovary Dysgerminoma


Pure dysgerminoma of the ovary: CT and MRI features with pathological correlation in 13 tumors.

J Ovarian Res 2020 Jun 17;13(1):71. Epub 2020 Jun 17.

Department of Radiology, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.

Background: To investigate the spectrum of CT and MRI findings of dysgerminoma of the ovary.

Methods: CT and MRI imaging of 12 patients with 13 histologically proven dysgerminomas of the ovary were retrospectively reviewed. Patients ages ranged from 6 ~ 27 years (mean, 17. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13048-020-00674-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301981PMC

[Management of intra-abdominal dysgerminoma During pregnancy - A Case Report and Literature Review].

Z Geburtshilfe Neonatol 2020 Apr 2. Epub 2020 Apr 2.

Schwerpunkt Geburtshilfe, Krankenhaus Barmherzige Brüder Regensburg, Frauenklinik Sankt Hedwig, Regensburg.

Introduction: Dysgerminomas are rare malignant germ cell tumors. They usually arise from the ovary, but case reports describing extraovarian dysgerminomas do exist. When treated adequately the disease has a good prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1112-0506DOI Listing

Role of staging surgery and adjuvant chemotherapy in adult patients with apparent stage I pure immature ovarian teratoma after fertility-sparing surgery.

Int J Gynecol Cancer 2020 May 15;30(5):664-669. Epub 2020 Mar 15.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

Objective: The standard treatment for young patients with stage I malignant ovarian germ cell tumors, except stage I dysgerminoma and stage IA G1 immature teratoma, is unilateral salpingo-oophorectomy with complete staging surgery followed by platinum-based chemotherapy. However, the role of complete staging surgery and adjuvant chemotherapy remains controversial. The aim of this study was to investigate the role of complete staging surgery and adjuvant chemotherapy in patients with early-stage pure immature teratoma after fertility-sparing surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/ijgc-2019-001116DOI Listing

Trends in the surgical management of malignant ovarian germcell tumors.

Gynecol Oncol 2020 Apr 31;157(1):89-93. Epub 2020 Jan 31.

Division of Gynecologic Oncology, University of Pennsylvania Health System, Philadelphia, PA, USA.

Objective: To evaluate trends in the surgical management of young women and pediatric patients with malignant ovarian germ cell tumors (MOGCTs) and associated survival outcomes.

Materials And Methods: Using the Surveillance, Epidemiology, and End Results database we identified patients under 40 years who underwent surgery between 1994 and 2014. The Joinpoint Regression Program was employed to investigate the presence of temporal trends and calculate average annual percent change (AAPC) rates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygyno.2020.01.033DOI Listing

Malignant Mixed Germ Cell Tumors of the Ovary: A Series of Rare Cases.

J Reprod Infertil 2019 Oct-Dec;20(4):231-236

Department of Pathology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.

Background: Malignant mixed germ cell tumors of ovary are rare aggressive cancers affecting young adolescent girls. The commonest combination reported in literature is dysgerminoma and endodermal sinus tumors but in our study the most common combination was immature teratoma and endodermal sinus tumor which is exteremely rare. Preservation of future fertility is a concern. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928409PMC
January 2020

Ovarian germ cell tumour classification: views from the testis.

Histopathology 2020 Jan;76(1):25-36

Centre for Molecular Oncology, Barts Cancer Institute, Charterhouse Square, Queen Mary University of London, London, UK.

The classification of ovarian germ cell tumours has remained unchanged for many years, while there have been considerable changes in the testicular classification. In recent years there has been concern about the overtreatment of clinical stage 1 testicular germ cell tumours with increasing use of surveillance for low-risk disease. We outline here the current classification of germ cell tumours of the ovary with particular regard to treatment and outcome and highlight some areas which may cause confusion, particularly pertaining to immature teratomas and mixed germ cell tumours. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/his.14016DOI Listing
January 2020

Malignant Lymphoma of the Ovary: A Diagnostic Pitfall of Intraoperative Consultation.

Int J Gynecol Pathol 2020 Jan;39(1):79-83

Departments of Obstetrics and Gynecology (N.I., Y.F., T.S., A.K., T.O., F.K.) Pathology (Y. Ikura, Y. Iwai) Hematology (M.O.), Takatsuki General Hospital, Takatsuki, Japan.

Primary ovarian lymphomas are rare, but can potentially evoke diagnostic problems. We present a case of ovarian lymphoma, in which an ambiguous intraoperative pathologic report led to overtreatment (unnecessary surgery). A 73-yr-old woman with fatigue and low-grade fever was diagnosed as having a left ovarian tumor by imaging modalities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PGP.0000000000000571DOI Listing
January 2020

What is your diagnosis? Coelomic effusion in a skittering frog.

Vet Clin Pathol 2020 Mar 27;49(1):158-160. Epub 2019 Nov 27.

Department of Biomedical Engineering and Mechanics, Virginia Tech University, Blacksburg, VA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/vcp.12808DOI Listing

Canine ovarian gonadoblastoma with dysgerminoma overgrowth: a case study and literature review.

J Ovarian Res 2019 Sep 23;12(1):89. Epub 2019 Sep 23.

Department of Pathology and Molecular Immunology of the Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua Jorge Viterbo Ferreira nr.228, 4050-313, Porto, Portugal.

Background: Gonadoblastoma (GB) is a rare mixed germ cell-sex cord-stromal tumour, first described in humans, commonly found in dysgenetic gonads of intersex patients that have a Y chromosome. However, this entity in not recognized in the WHO classification of tumours of genital system of domestic animals. Herein, we describe a case of ovarian gonadoblastoma with proliferation of dysgerminoma and sex cord-stromal tumour components, in a phenotypically and cytogenetically normal bitch. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13048-019-0561-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757443PMC
September 2019
3 Reads

Genetic Causes of Rare Pediatric Ovarian Tumors.

Klin Onkol 2019 ;32(Supplementum2):79-91

Background: Ovarian tumors in childhood and adolescence are distinguished from those that arise in adulthood by their histological subtype. These tumors may arise as the first manifestation of a cancer predisposition syndrome. Correct diagnosis of the syndrome may offer the possibility of surveillance for other members of the patients family. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14735/amko2019S79DOI Listing
January 2020
8 Reads

Germ Cell Tumors of the Female Genital Tract.

Surg Pathol Clin 2019 Jun;12(2):621-649

Department of Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard Unit 85, Houston, TX 77030, USA. Electronic address:

Ovarian germ cell tumors are a histologically diverse group of neoplasms with a common origin in the primitive germ cell. The vast majority are represented by mature cystic teratoma. In the minority are malignant germ cell tumors including immature teratoma, dysgerminoma, yolk sac tumor, embryonal cell carcinoma, and choriocarcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.path.2019.01.005DOI Listing
June 2019
13 Reads

Prognostic significance of residual disease in advanced stage malignant ovarian germ cell tumors.

Int J Gynecol Cancer 2019 03 29;29(3):554-559. Epub 2019 Jan 29.

Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York City, New York, USA.

Objective: To investigate the prognostic significance of complete gross resection following cytoreductive surgery for patients with advanced stage malignant ovarian germ cell tumors.

Methods: The National Cancer Data Base was accessed and patients diagnosed with an advanced stage (II-IV) malignant ovarian germ cell tumor who underwent primary cytoreductive surgery between 2011 and 2014 were selected for further analysis. For analysis purposes two groups were formed: patients with complete gross resection and those with macroscopic residual disease. Read More

View Article

Download full-text PDF

Source
http://ijgc.bmj.com/lookup/doi/10.1136/ijgc-2018-000013
Publisher Site
http://dx.doi.org/10.1136/ijgc-2018-000013DOI Listing
March 2019
26 Reads

'Size does matter': Prophylactic gonadectomy in a case of Swyer syndrome.

J Gynecol Obstet Hum Reprod 2019 Apr 25;48(4):283-286. Epub 2019 Jan 25.

Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Swyer syndrome also known as pure or complete gonadal dysgenesis is a very rare disorder of sex development wherein the individuals are phenotypically females with 46, XY genotype and preserved mullerian structures. These individuals characteristically have dysgenetic streak gonads which carry an increased risk of malignant transformation. Prophylactic gonadectomy is highly recommended as soon as a clinical diagnosis is established to diminish the chances of tumor development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jogoh.2019.01.009DOI Listing
April 2019
6 Reads

Prognostic Impact of Lymphadenectomy in Different Stages of Malignant Germ Cell Tumor of the Ovary Based on Propensity Score Matching.

Comb Chem High Throughput Screen 2018 ;21(9):652-661

Department of Gynecology and Obstetrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Background: Lymphadenectomy has been widely used in the treatment of malignant germ cell tumor of the ovary (OGCT), which is a kind of ovarian cancers occurred mostly in young women and adolescent girls. But the clinical decision mainly depends on the doctor's experience without a well-defined guideline. This population-based study aimed to evaluate the prognostic impact of lymphadenectomy in different stages of malignant germ cell tumors of the ovary. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/168495/article
Publisher Site
http://dx.doi.org/10.2174/1386207322666181220121836DOI Listing
July 2019
35 Reads

Pitfalls of Frozen Section in Gynecological Pathology: A Rare Case of Ovarian Lymphoma in an HIV-Positive Woman Resembling Dysgerminoma on Frozen Section.

Int J Surg Pathol 2019 Jun 25;27(4):387-389. Epub 2018 Nov 25.

1 Rutgers-New Jersey Medical School, Newark, NJ, USA.

Primary lymphoma of the ovary, particularly in an HIV-positive woman, is exceptionally rare, and ovarian lymphoma may not be considered at the time of intraoperative consultation. In this article, we present a case in an HIV-positive woman thought to be a dysgerminoma at the time of frozen section, but which was found to be a diffuse large B-cell lymphoma of the ovary. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1066896918813658DOI Listing
June 2019
27 Reads

Pediatric ovarian dysgerminoma with highly elevated serum neuron-specific enolase.

Pediatr Int 2018 Oct;60(10):982-983

Department of Pediatrics, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/ped.13676
Publisher Site
http://dx.doi.org/10.1111/ped.13676DOI Listing
October 2018
23 Reads

Treatment of bilateral ovarian dysgerminoma with 11-year follow-up: A case report.

Ann Med Surg (Lond) 2018 Sep 21;33:50-52. Epub 2018 Aug 21.

Faculdade de Medicina (FAMED) - Universidade Federal do Rio Grande (FURG), Rio Grande city, Rio Grande do Sul State, Brazil.

Introduction: Malignant ovarian germ cell tumors (MOGCTs) are rare malignancies with an incidence of about 0.5/100,000. They account for less than 5% of all ovarian tumors, of which 32. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amsu.2018.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122391PMC
September 2018
44 Reads

[Pathologic features on gonadal changes of sexual developmental disorders in children].

Zhonghua Bing Li Xue Za Zhi 2018 Jul;47(7):531-535

Department of Pediatric Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.

To investigate the pathologic features of gonadal tissues of disorders of sexual development (DSD) in children. Fifty-three cases of gonadal developmental disorders were collected from July 2015 to August 2017 at Guangzhou Women and Children's Medical Center. Clinical manifestations, karyotypes, sex hormone levels, ultrasound imaging, histology and immunophenotype of gonadal tissues were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.07.010DOI Listing
July 2018
52 Reads

Torsion of Ovarian Dysgerminoma in a Child: Role of Computed Tomography.

Cureus 2018 Apr 23;10(4):e2522. Epub 2018 Apr 23.

Department of Pathology & Laboratory Medicine, The Aga Khan University, Karachi, PAK.

Dysgerminomas are malignant germ cell tumors of the ovary that most commonly occur in the adolescent population. Ovarian dysgerminoma presenting with complications like torsion is a rare entity in the pediatric age group. Cross-sectional imaging plays a crucial role in diagnosis, tumor staging before surgical resection, and for planning adjuvant chemotherapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.2522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016000PMC
April 2018
11 Reads

Germ Cell Tumor Ovary: an Institutional Experience of Treatment and Survival Outcomes.

Indian J Surg Oncol 2018 Jun 10;9(2):215-219. Epub 2018 Apr 10.

1Department of Surgical Oncology, King George's Medical University, Lucknow, Uttar Pradesh 226003 India.

Malignant germ cell tumors (GCT) of the ovary account for 2-3% of all ovarian neoplasms and occur mostly in the second and third decade of life. Over the past three decades, survival rates for germ cell tumors have dramatically improved, coincident with more aggressive surgical staging and combination chemotherapy. Although there are several studies describing ovarian GCT and fertility-preserving surgery in the western population, there is very little Indian data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13193-018-0742-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984860PMC
June 2018
51 Reads

Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults?

Gynecol Oncol 2018 08 5;150(2):253-260. Epub 2018 Jun 5.

Children's and Young Persons Cancer Services, University College London Hospital Trusts, London, UK.

Objective: Dysgerminoma is the most common malignant ovarian germ cell tumor (GCT) with peak incidence during adolescence and young adulthood. Current standard of care for patients with disease that has spread outside of the ovary (advanced-stage) utilizes platin-based chemotherapy regimens. The study objective was to compare clinical outcomes between platin-based (carboplatin versus cisplatin) strategies across all age groups (children < 11 years (y), adolescents = 11-25 y and young adult women > 25 y) for advanced-stage dysgerminoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygyno.2018.05.025DOI Listing
August 2018
56 Reads

Synchronous adrenocortical carcinoma and ovarian malignant mixed germ cell tumor: A case report and literature review.

Medicine (Baltimore) 2018 May;97(20):e10730

Department of Pathology, West China Second Hospital of Sichuan University.

Rationale: Adrenocortical carcinoma (ACC) is an endocrine malignancy with poor prognosis, which commonly arises in a sporadic manner, but may also become a part of a familial syndrome. ACC rarely arises simultaneously with other malignant tumors.

Patient Concerns: We report a case of a 29-year-old woman with ACC synchronously followed by an ovarian malignant mixed germ cell tumor. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00005792-201805180-0002
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000010730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976290PMC
May 2018
26 Reads

Anti-Muellerian hormone concentration in bitches with histopathologically diagnosed ovarian tumours and cysts.

Reprod Domest Anim 2018 Jun 30;53(3):784-792. Epub 2018 Mar 30.

Laboklin GmbH & Co.KG, Bad Kissingen, Germany.

Increased concentrations of Anti-Muellerian hormone (AMH) can indicate a granulosa cell tumour as shown in women, mares and cows. To investigate AMH to differentiate canine granulosa cell tumour from other ovarian pathologies, we evaluated the ovaries of 63 bitches. Blood serum samples were collected before surgery for AMH analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/rda.13171DOI Listing
June 2018
28 Reads

Ovarian dysgerminoma in pregnancy: A case report and literature review.

Cancer Biol Ther 2018 08 25;19(8):649-658. Epub 2018 Apr 25.

a Obstetrics and Gynecology Department , Tianjin Medical University General Hospital , No.154, Anshan Road, Heping District , Tianjin , China.

Background: Dysgerminoma is an uncommon malignant tumor arising from the germ cells of the ovary. Its association with pregnancy is extremely rare; the incidence is about 0.2-1 per 100,000 pregnancies. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/15384047.2018.1
Publisher Site
http://dx.doi.org/10.1080/15384047.2018.1450118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067899PMC
August 2018
23 Reads

Imaging findings of ovarian dysgerminoma with emphasis on multiplicity and vascular architecture: pathogenic implications.

Abdom Radiol (NY) 2018 07;43(7):1515-1523

Department of Radiology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.

We report the imaging findings of three ovarian dysgerminomas that coexisted with other germ cell tumors or gonadoblastomas, focusing on the distribution of tumor nests and vascular architecture, which might provide information about the pathogenesis of dysgerminomas. In a 14-year-old female with dysgerminoma and coexisting gonadoblastomas, contrast-enhanced magnetic resonance imaging (MRI) demonstrated a solid mass in the right ovary, which presented as hyperintense lobules on diffusion-weighted imaging separated by fibrovascular septa. Some small nodules were found to exist separately from the lobules (multiplicity) and to include pathological remnants of gonadoblastoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00261-018-1503-6DOI Listing
July 2018
48 Reads

Successful Laparoscopic Treatment of Chylous Ascites after Pelvic Lymphadenectomy: A Case Report and Peanut Oil Application.

J Minim Invasive Gynecol 2018 Jul - Aug;25(5):923-926. Epub 2018 Feb 7.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address:

A 23-year-old female patient with refractory chylous ascites was successfully treated with laparoscopic ligation of the ruptured lymphatic vessel. The young patient developed abdominal distention after right-side pelvic lymph node dissection for dysgerminoma of the right ovary. Conservative managements failed to control the symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmig.2017.12.028DOI Listing
July 2019
25 Reads

[The value of immunohistochemistry using SMARCA4/BRG1 in the diagnosis of small cell ovarian carcinoma hypercalcemic type. A report of two cases].

Rev Esp Patol 2018 Jan - Mar;51(1):61-67. Epub 2017 Mar 28.

Servicio de Anatomía Patológica, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España.

Small cell carcinoma of ovary-hypercalcemic type is an undifferentiated carcinoma. We describe two cases in women aged 32 and 29. Both presented with large masses and complete surgical extirpation was impossible. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.patol.2017.02.002DOI Listing
February 2019
21 Reads

Gonadal dysgenesis is associated with worse outcomes in patients with ovarian nondysgerminomatous tumors: A report of the Children's Oncology Group AGCT 0132 study.

Pediatr Blood Cancer 2018 04 29;65(4). Epub 2017 Dec 29.

Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts.

Purpose: In this report, we characterize the timing and behavior of malignant ovarian germ cell tumors (GCTs) in pediatric patients with dysgenetic gonads compared to those with normal gonadal development.

Patients And Methods: Patients from the Children's Oncology Group AGCT0132 with malignant ovarian GCTs were included. Within this population, we sought to identify patients with gonadoblastoma, streak ovaries, or other evidence of gonadal dysgenesis (GD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.26913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219870PMC
April 2018
68 Reads

Adolescent Female With Turner's Syndrome and 46,X,der(Y) del(Y)(p11.2)del(q11.2) Karyotype With Gonadoblastoma and Dysgerminoma.

Pediatr Dev Pathol 2017 Nov-Dec;20(6):506-510. Epub 2017 Feb 9.

1 Department of Obstetrics and Gynecology, Monmouth Medical Center, Long Branch, New Jersey.

Gonadal dysgenesis patients with Y chromosomal material are subject to increased risk for germ cell tumors. We report a case of an adolescent female presenting with Turner-like syndrome with primary amenorrhea and Tanner stage 1 breast development. Karyotype showed one X chromosome and a minute pericentromeric fragment of Y chromosome without any functional Y genes in all the cells, unlike a mosaic pattern, represented as 46,X,der(Y)del(Y)(p11. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526617690291DOI Listing
May 2019
35 Reads

Fertility-preserving surgery for advanced stage ovarian germ cell tumors.

Gynecol Oncol 2017 12 9;147(3):493-496. Epub 2017 Oct 9.

Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.

Objective: To evaluate the prevalence and safety of uterine preservation among premenopausal women diagnosed with a malignant ovarian germ-cell tumor (MOGCT) of advanced stage (stage II-IV).

Materials And Methods: The National Cancer Database was accessed and a cohort of women aged <40years, diagnosed with a MOGCT were identified. Those with stage II-IV disease who underwent cancer-directed surgery and received chemotherapy were selected for further analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygyno.2017.10.010DOI Listing
December 2017
24 Reads

Case Report: Use of Tumor and Germline Y Chromosomal Analysis to Guide Surgical Management in a 46, XX Female Presenting With Gonadoblastoma With Dysgerminoma.

Int J Gynecol Pathol 2017 Sep;36(5):466-470

Familial Breast & Ovarian Cancer Clinic (J.M.C., R.H.K.), Princess Margaret Cancer CentreDepartments of Molecular Genetics (J.M.C.)Laboratory Medicine and Pathobiology (LMP) (A.N., T.C.), Faculty of MedicineObstetrics and Gynecology (R.F.C., F.M.), Division of Reproductive SciencesMedicine (R.H.K.), Division of Medical Oncology and Hematology, University of TorontoDepartment of Pathology and Laboratory Medicine (A.N., T.C.)Lunenfeld-Tanenbaum Research Institute (R.F.C., F.M., T.C.), Mount Sinai Hospital, Toronto, ON, CanadaWilliam Beaumont School of Medicine (B.R.), Oakland University, RochesterDivision of Gynecologic Oncology (B.R.), Beaumont Health, Royal Oak, Michigan.

Gonadoblastomas are rare mixed gonadal tumors that are almost always found in individuals with 46, XY karyotype or some other form of Y chromosome mosaicism. It is extremely rare to diagnose gonadoblastoma in phenotypically normal 46, XX females. Herein, we present a 20-year-old 46, XX female diagnosed with gonadoblastoma and dysgerminoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PGP.0000000000000349DOI Listing
September 2017
25 Reads

Epithelial-mesenchymal transition markers in malignant ovarian germ cell tumors.

APMIS 2017 Sep 6;125(9):781-786. Epub 2017 Jun 6.

Department of Pathology, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway.

The purpose of this study was to determine the expression and potential clinical role of epithelial-to-mesenchymal transition (EMT)-related factors in malignant ovarian germ cell tumors (MOGCT). Protein expression of E-cadherin, N-cadherin, P-cadherin, Zeb1, HMGA2, and vimentin by immunohistochemistry was analyzed in 42 MOGCT from patients treated in Norway during the period 1981-2001. Expression was analyzed for association with clinicopathologic parameters. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.12715DOI Listing
September 2017
24 Reads

Complications of dysgerminoma: meeting the health needs of patients in conflict zones.

BMJ Case Rep 2017 Jan 30;2017. Epub 2017 Jan 30.

Ziv Medical Center, Tzfat, Israel.

A symptom of prolonged conflict is the destruction of infrastructure and healthcare systems. While the need for acute trauma services is obvious in conflict zones, patients with chronic diseases also require care. This report describes the clinical course of a young teenage girl with a large mid pelvic tumour originating from the left ovary and reaching the umbilicus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2016-217787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293957PMC
January 2017
17 Reads

Dual malignancy in adolescence: A rare case report of metachronous papillary carcinoma of thyroid following dysgerminoma of ovary.

J Res Med Sci 2016 8;21:21. Epub 2016 Apr 8.

Department of Surgical Oncology, Sri Aurobindo Medical College and Post Graduate Institute (SAMC & PGI), Indore, Madhya Pradesh, India.

Dual malignancy is rare in adolescents. Dual malignancy with the second malignancy of thyroid is rare. No association has been reported between dysgerminoma of ovary and carcinoma thyroid in medical literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/1735-1995.179889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121993PMC
April 2016
22 Reads

Dysgerminoma developing from an ectopic ovary in a patient with WAGR syndrome: A case report.

Mol Clin Oncol 2016 Nov 25;5(5):503-506. Epub 2016 Aug 25.

Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan.

WAGR syndrome is caused by an 11p13 deletion and includes Wilms' tumor, aniridia, genitourinary anomalies and mental retardation. We encountered a case of a dysgerminoma originating in an ectopic ovary in a woman with WAGR syndrome. Our patient was a 24-year-old nulliparous woman who was diagnosed with WAGR syndrome. Read More

View Article

Download full-text PDF

Source
https://www.spandidos-publications.com/10.3892/mco.2016.1004
Publisher Site
http://dx.doi.org/10.3892/mco.2016.1004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103847PMC
November 2016
40 Reads

Ovarian clear cell carcinoma with plasma cell-rich inflammatory stroma: Cytological Findings of a Case.

Diagn Cytopathol 2017 Feb 8;45(2):128-132. Epub 2016 Oct 8.

Department of Gynecology, Shiga Medical Center for Adults, Moriyama, Shiga, 524-8524, Japan.

We report a case of clear cell carcinoma (CCC) of the ovary with plasma cell-rich inflammatory stroma, a recently proposed subtype of CCC, and present the cytological findings. The patient was a 48-year-old woman, who was incidentally found to have a right ovarian tumor during the preoperative work-up for an early-stage adenocarcinoma of the uterine cervix. Cytological examination of an imprint smear of the ovarian tumor and peritoneal washing revealed solid cell clusters of irregular, often dendritic shapes, which were intermingled with many inflammatory cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dc.23609DOI Listing
February 2017
28 Reads

An Incidental Finding of Bilateral Dysgerminoma During Cesarean Section: Dilemmas in Management.

J Clin Diagn Res 2016 Aug 1;10(8):QD04-5. Epub 2016 Aug 1.

Senior Specialist, Department of Obstetrics and Gynaecology, Hindu Rao Hospital , Delhi, India .

Dysgerminoma is an uncommon malignant tumour arising from germ cells of ovary. It occurs mostly in the reproductive age group. Its association with pregnancy is rare. Read More

View Article

Download full-text PDF

Source
http://jcdr.net/article_fulltext.asp?issn=0973-709x&year
Publisher Site
http://dx.doi.org/10.7860/JCDR/2016/20163.8319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028588PMC
August 2016
30 Reads

On the histogenesis of mixed germ cell-sex cord stromal tumour of the gonads.

J Clin Pathol 2017 Mar 25;70(3):222-227. Epub 2016 Jul 25.

Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Aims: The origin of testicular mixed germ cell-sex cord stromal tumour (MGC-SCST) is uncertain, and the nature of this neoplasm is controversial. It has not been established whether the germ cells in testicular MGC-SCST are neoplastic or whether they are merely entrapped within an unclassified sex cord stromal tumour or related testicular neoplasm. In this investigation, we present additional evidence regarding the nature of the germ cells in testicular MGC-SCST. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jclinpath-2016-203902DOI Listing
March 2017
43 Reads

Accuracy of intra-operative frozen section and its role in the diagnostic evaluation of ovarian tumors.

Eur J Gynaecol Oncol 2016 ;37(2):216-20

Unlabelled: Summary

Objective: This retrospective study was undertaken to evaluate the accuracy and role of intra-operative frozen section in the diagnosis of ovarian tumors.

Materials And Methods: Retrospective study of 804 ovarian frozen section results between June 2010 and June 2014 was examined to determine the accuracy of frozen section diagnosis. The intra-operative frozen section diagnosis was compared with the permanent (paraffin) section and the overall accuracy, sensitivity, specificity, and positive and negative predictive values of the frozen section were studied. Read More

View Article

Download full-text PDF

Source
July 2016
25 Reads

Outcomes of Surgery Alone and Surveillance Strategy in Young Women With Stage I Malignant Ovarian Germ Cell Tumors.

Int J Gynecol Cancer 2016 06;26(5):859-64

Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Objectives: This study aimed to evaluate the safety of surgery alone followed by surveillance in young women with stage I malignant ovarian germ cell tumor (MOGCT).

Methods: A retrospective review was performed on 31 patients with stage I MOGCT who were treated by surgery alone with follow-up.

Results: The median patient age was 22 years (range, 6-45 years). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IGC.0000000000000702DOI Listing
June 2016
96 Reads

Gonadoblastoma and Papillary Tubal Hyperplasia in Ovotesticular Disorder of Sexual Development.

J Clin Res Pediatr Endocrinol 2016 Sep 18;8(3):351-5. Epub 2016 Apr 18.

Osmangazi University Faculty of Medicine, Departments of Pediatric Endocrinology, Eskişehir, Turkey, Phone: +90505 496 23 02 E-mail:

Ovotesticular disorder of sexual development (DSD), formerly known as true hermaphroditism, is a rare form of DSD in which both testicular and ovarian tissues are present in the same individual either in a single gonad (ovotestis) or in opposite gonads with a testis and an ovary on each side. The diagnosis of ovotesticular DSD is based solely on the presence of ovarian and testicular tissue in the gonad and not on the characteristics of the internal and external genitalia, even if ambiguous. Herein, we report two patients with ovotesticular DSD-one presenting with ambiguous genitalia on the third day after birth and the other with short stature and primary amenorrhea in adolescence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4274/jcrpe.2705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096502PMC
September 2016
46 Reads

Utility of Ultrasound and Magnetic Resonance Imaging in Patients with Disorders of Sex Development Who Undergo Prophylactic Gonadectomy.

J Pediatr Adolesc Gynecol 2016 Dec 11;29(6):577-581. Epub 2016 Apr 11.

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan.

Study Objective: To evaluate ultrasonography and magnetic resonance imaging (MRI) in identifying gonads in patients with disorders of sex development (DSD) who undergo prophylactic gonadectomy, and to assess the capacity of preoperative imaging to detect premalignant and malignant transformation.

Design, Setting, And Participants: Retrospective cohort at a tertiary referral center of 39 patients with DSD who underwent MRI and/or ultrasonography before prophylactic gonadectomy.

Interventions: None. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10833188163000
Publisher Site
http://dx.doi.org/10.1016/j.jpag.2016.03.007DOI Listing
December 2016
29 Reads

Ovarian dysgerminoma with normal serum tumour markers presenting in a child with precocious puberty.

J Cancer Res Ther 2015 Jul-Sep;11(3):661

Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt, and Consultant Pediatrician, Alhada Armed Forces Hospital, Taif, Saudi Arabia.

A 7-year-old female child was presented to the emergency room with acute abdominal pain and vaginal bleeding. Her assessment revealed a firm large lower abdominal mass with evidence of precocious puberty with bilaterally symmetrically enlarged breast (Tanner stage B4-P1-A1). Abdominal imaging showed a well-defined soft midline pelvi-abdominal single mass measuring 7. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/0973-1482.137920DOI Listing
August 2016
32 Reads

Treatment and ovarian preservation in children with ovarian tumors.

J Pediatr Surg 2015 Dec 15;50(12):2116-8. Epub 2015 Sep 15.

Department of Surgery, Division of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Background/purpose: Ovarian preservation is desirable in children with ovarian tumors. However, the diagnostic and treatment strategies are heterogeneous. The aim of this study was to investigate the management and preservation of ovarian tissue in order to identify the factors associated with ovarian preservation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpedsurg.2015.08.036DOI Listing
December 2015
23 Reads

Ovarian clear cell carcinoma with plasma cell-rich inflammatory stroma: a clear cell carcinoma subgroup with distinct clinicopathological features.

Histopathology 2016 Mar 6;68(4):588-95. Epub 2015 Sep 6.

Department of Anatomical Pathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Aims: Ovarian clear cell carcinoma has a unique stroma. Although a hyalinized or mucoid stroma is more common, the stroma sometimes shows a dense inflammatory infiltrate, simulating a dysgerminoma. The aim of this study was to analyse the character and significance of the inflammatory stroma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/his.12783DOI Listing
March 2016
22 Reads

Expression of Transcription Factors and Nuclear Receptors in Mixed Germ Cell-Sex Cord Stromal Tumor and Related Tumors of the Gonads.

Int J Gynecol Pathol 2015 Nov;34(6):528-34

Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana.

In this study, we compare the expression of OCT4, SALL4, and TSPYL1 in mixed germ cell-sex cord stromal tumor (MGC-SCST) of either gonad to that of normal adult testis, classic and spermatocytic seminoma, intratubular germ cell neoplasia, unclassified, gonadoblastoma, and dysgerminoma to determine the entity or entities that most closely resemble MGC-SCST by immunohistochemistry of germ cells. The most useful transcription factor was OCT4. In addition, to its already described value in distinguishing germinoma and embryonal carcinoma from yolk sac tumor and in differentiating classic from spermatocytic seminoma, we found that OCT4 is useful in confirming or ruling out potential malignancy in MGC-SCST of either gonad. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PGP.0000000000000192DOI Listing
November 2015
41 Reads

Yolk sac tumor of the ovary in a young girl with tuberous sclerosis: A case report and review of the literature.

Gynecol Oncol Rep 2014 Dec 6;10:9-12. Epub 2014 Dec 6.

Department of Surgery, Driscoll Children's Hospital, Corpus Christi, TX, USA.

•We reported the first tuberous sclerosis patient with an ovarian yolk sac tumor.•Although angiomyolipoma is a common benign tumor in TS patients, abdominal malignancies must be considered. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gore.2014.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434146PMC
December 2014
17 Reads

PRESUMPTIVE DYSGERMINOMA IN AN ORANGE-SPOT FRESHWATER STINGRAY (POTAMOTRYGON MOTORO).

J Zoo Wildl Med 2015 Jun;46(2):382-5

A captive-born, 13-yr-old female orange-spot freshwater stingray, (Potamotrygon motoro), presented with an acute caudodorsal swelling. Ultrasonography revealed an intracoelomic mass of mixed echogenicity containing fluid pockets. The ray was euthanatized and gross postmortem examination confirmed the presence of a fluid-filled coelomic mass in the region of the reproductive tract. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1638/2014-0148R.1DOI Listing
June 2015
23 Reads

Aberrant expression of pim-3 promotes proliferation and migration of ovarian cancer cells.

Asian Pac J Cancer Prev 2015 ;16(8):3325-31

Department of Medical Microbiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China E-mail :

Pim kinase-3(Pim-3), a member of serine/threonine protein kinases, has been implicated in multiple human cancers and involved in Myc-induced tumorigenesis. However, little is known regarding its expression and biological function in human ovarian cancer. In this study we showed that the clinical significance and biological functions of Pim-3 in ovarian cancer and found that higher Pim-3 mRNA level are detected in ovarian cancer tissues than those in normal ovarian tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7314/apjcp.2015.16.8.3325DOI Listing
February 2016
26 Reads