2,611 results match your criteria Ovary Sex Cord Stromal Tumors


Hyperandrogenism caused by ovarian Leydig cell tumour: finding the needle in a haystack.

BMJ Case Rep 2020 Dec 13;13(12). Epub 2020 Dec 13.

Medicine, Hospital Melaka, Bandar Melaka, Malaysia.

Leydig cell tumours (LCTs) of the ovary are rare ovarian tumours that usually present with hyperandrogenism. Conventional radiological imagings are helpful in localising these tumours. However, some tumours may be too small to be localised before curative surgical removal. Read More

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December 2020

Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation.

Radiographics 2021 Jan-Feb;41(1):289-315. Epub 2020 Nov 13.

From the Department of Radiology and Biomedical Imaging (E.C.T., M.M.) and Department of Pathology (L.I.), Yale School of Medicine, 333 Cedar St, PO Box 208042, Room TE-2, New Haven, CT 06520.

Ovarian neoplasms can be categorized on the basis of histopathologic features into epithelial surface cell tumors, germ cell tumors, sex cord-stromal tumors, and metastases. While their imaging appearance is often nonspecific, it closely parallels the gross pathologic appearance, and radiologic-pathologic correlation is helpful to aid in a deeper understanding of the subtypes. Epithelial cell neoplasms are the most common category, and they can be benign, borderline, or malignant. Read More

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November 2020

Management of recurrent granulosa cell tumor of the ovary: Contemporary literature review and a proposal of hyperthermic intraperitoneal chemotherapy as novel therapeutic option.

J Obstet Gynaecol Res 2021 Jan 25;47(1):44-51. Epub 2020 Oct 25.

Chief of Peritoneal Surface Malignancy Program and Director of the Center for Gastrointestinal Malignancies, MedStar Washington Cancer Institute, Washington, District of Columbia, USA.

Granulosa cell tumors of the ovary (GCT) are the most common type of sex cord stromal tumors. Although most of patients are diagnosed at early stage and has favorable 5-year overall survival rate, 16-23% of GCT ultimately develop recurrent disease. Recurrences are characterized by disseminated peritoneal metastasis. Read More

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January 2021

Leydig cell ovarian tumor - clinical case description and literature review.

Prz Menopauzalny 2020 Sep 2;19(3):140-143. Epub 2020 Oct 2.

Department of Gynaecology, Medical University of Silesia, Katowice, Poland.

Leydig cell ovarian tumors constitute not only a medical problem for clinicians but also a social problem - which is why women with symptoms of hirsutism relatively quickly contact physicians for medical consultation. Leydig cell ovarian tumor is a rare sex cord-gonadal stromal tumor which constitutes less than 0.5% of ovarian tumors. Read More

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September 2020

Adult granulosa cell tumors of bilateral ovaries with pure cystic presentation: A case report and review of literature.

Medicine (Baltimore) 2020 Oct;99(40):e22511

Department of Pathology, Xingtai People's Hospital, Hebei Medical University Affiliated Hospital, Xingtai, Hebei, P.R. China.

Rationale: Granulosa cell tumors (GCTs) are rare, hormonally active sex cord-stromal tumors that generally present as solid unilateral ovarian lesions. It's quite uncommon that they present as pure bilateral ovarian cysts. Histopathology remains the gold standard for making a diagnosis of GCTs. Read More

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October 2020

Gonadoblastoma versus ovarian mixed germ cell-sex cord stromal tumor in women or girls with no evidence of a disorder of sex development: A problem in differential diagnosis.

Pathol Res Pract 2020 Nov 5;216(11):153198. Epub 2020 Sep 5.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Van Nuys Medical Science Building 128, 635 Barnhill Drive, Indianapolis, IN 46240-5120, United States; Department of Urology, Indiana University School of Medicine, Indianapolis, IN 46240-5120, United States.

Gonadoblastoma occurring in a normal girl or woman has been confused with ovarian mixed germ cell-sex cord stromal tumor (MGC-SCST) due to a lack of knowledge that the former occurs occasionally in a normal woman or girl. In this article, we develop histological criteria that facilitate the distinction of gonadoblastoma in an individual with a normal karyotype and no evidence of a disorder of sex development from ovarian MGC-SCST. We reviewed the histological findings of gonadoblastoma occurring in normal individuals and compared them to cases of ovarian MGC-SCST in our files. Read More

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November 2020

New small-molecule compound Hu-17 inhibits estrogen biosynthesis by aromatase in human ovarian granulosa cancer cells.

Cancer Med 2020 12 1;9(23):9081-9095. Epub 2020 Oct 1.

Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Estrogen-dependent cancers (breast, endometrial, and ovarian) are among the leading causes of morbidity and mortality in women worldwide. Aromatase is the main enzyme that catalyzes the biosynthesis of estrogen, which drives proliferation, and antiestrogens can inhibit the growth of these estrogen-dependent cancers. Hu-17, an aromatase inhibitor, is a novel small-molecule compound that suppresses viability of and promotes apoptosis in ovarian cancer cells. Read More

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December 2020

Magnetic Resonance Imaging of Recurrent Adult Granulosa Cell Tumor of the Ovary: A Retrospective Analysis of 11 Cases.

J Comput Assist Tomogr 2020 Nov/Dec;44(6):887-892

Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.

Objective: The aim of the study was to characterize magnetic resonance imaging findings in patients with recurrent ovarian adult granulosa cell tumors (AGCTs).

Methods: Clinical and magnetic resonance imaging manifestations of recurrent AGCTs were evaluated in 11 patients.

Results: Initial recurrences of AGCT were diagnosed between 13 months and 30 years (mean, 11. Read More

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December 2020

Does uterine preservation affect survival outcomes of patients with stage I ovarian sex cord-stromal cell tumours? A multi-institutional study.

Eur J Obstet Gynecol Reprod Biol 2020 Nov 8;254:52-56. Epub 2020 Sep 8.

Department of Obstetrics and Gynaecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Objective: Sex cord-stromal tumours of the ovary are relatively uncommon neoplasms that account for 3 % of all ovarian cancers. Uterine preservation with careful staging is achievable; however, conservative surgery remains controversial. This study examined the prognostic effects of uterine preservation in patients with stage I sex cord-stromal tumours. Read More

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November 2020

Active immunisation against GnRH as treatment for unilateral granulosa theca cell tumour in mares.

Equine Vet J 2021 Jul 2;53(4):740-745. Epub 2020 Oct 2.

Unit for Reproductive Medicine - Clinic for Horses, University of Veterinary Medicine, Hannover, Germany.

Background: Stallion-like or aggressive behaviour in mares affected by unilateral granulosa theca cell tumour (GTCT) is well-known, but use of a GnRH-vaccine as an alternative to surgical removal of the neoplastic ovary has not been investigated.

Objectives: To determine the effect of immunisation against GnRH on ovarian size, testosterone concentration, Anti-Müllerian hormone (AMH) concentration, and owner-reported behaviour in four mares affected by unilateral GTCT.

Study Design: Retrospective case report. Read More

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Rare DICER1 and Absent FOXL2 Mutations Characterize Ovarian Juvenile Granulosa Cell Tumors.

Am J Surg Pathol 2021 02;45(2):223-229

Departments of Pathology.

FOXL2 somatic mutation occurs in a high percentage of ovarian adult granulosa cell tumors and DICER1 mutations in a high proportion of Sertoli-Leydig cell tumors. These mutations have only been studied in a limited number of juvenile granulosa cell tumors (JGCTs), and their occurrence and frequency in these neoplasms is controversial. We aimed to determine the frequency of FOXL2 and DICER1 mutations in a large cohort of 50 JGCTs, and to evaluate the prognostic impact of these mutations. Read More

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February 2021

Ovarian mixed germ cell-sex cord-stromal tumour in a European seabass, Dicentrarchus labrax (Linnaeus, 1758).

J Fish Dis 2020 Nov 1;43(11):1453-1457. Epub 2020 Sep 1.

Department of Agrifood, Environmental and Animal Sciences, University of Udine, Udine, Italy.

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November 2020

Unclassified Mixed Germ Cell-Sex Cord-Stromal Tumor of the Ovary: An Unusual Case Report.

Cureus 2020 Jul 23;12(7):e9350. Epub 2020 Jul 23.

Gynecologic Oncology, Clinica de Oncologia Astorga, Universidad Pontificia Bolivariana, Medellín, COL.

Unclassified mixed germ cell-sex cord-stromal tumor (UMGC-SCST) is a rare ovarian neoplasm composed of germ cells and sex cord elements, which occurs in genetically and phenotypically normal women without the usual histological features seen in gonadoblastoma. Few cases have been reported in the literature so far. The age of presentation is more frequent in girls younger than 10 years of age, although it can also occur in adult women. Read More

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Sertoli-Leydig Cell Tumors of the Ovary With Follicular Differentiation Often Resembling Juvenile Granulosa Cell Tumor: A Report of 38 Cases Including Comments on Sex Cord-Stromal Tumors of Mixed Forms (So-called Gynandroblastoma).

Am J Surg Pathol 2021 01;45(1):59-67

James Homer Wright Pathology Laboratories, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Thirty-eight ovarian Sertoli-Leydig cell tumors that contained follicles are described; in 33 of them follicles imparted a microscopic appearance resembling that of the juvenile granulosa cell tumor. The average age of the patients (28 y), frequency of androgenic manifestations (40%), and dominant histopathologic features were all typical of Sertoli-Leydig cell tumor, mostly (80%) of intermediate differentiation. The remaining tumors were poorly differentiated; none were well differentiated. Read More

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January 2021

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.

JCI Insight 2020 08 20;5(16). Epub 2020 Aug 20.

Department of Radiation Oncology and.

Granulosa cell tumors (GCT) are rare ovarian malignancies. Due to the lack of effective treatment in late relapse, there is a clear unmet need for novel therapies. Forkhead Box L2 (FOXL2) is a protein mainly expressed in granulosa cells (GC) and therefore is a rational therapeutic target. Read More

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CircPSMC3 alleviates the symptoms of PCOS by sponging miR-296-3p and regulating PTEN expression.

J Cell Mol Med 2020 09 17;24(18):11001-11011. Epub 2020 Aug 17.

Reproductive Medical Center, Renmin Hospital, Wuhan University, Wuhan, China.

Polycystic ovary syndrome (PCOS), the most common female endocrine disease that causes anovulatory infertility, still lacks promising strategy for the accurate diagnosis and effective therapeutics of PCOS attributed to its unclear aetiology. In this study, we determined the abnormal reduction in circPSMC3 expression by comparing the ovarian tissue samples of PCOS patients and normal individuals. The symptom relief caused by up-regulation of circPSMC3 in PCOS model mice suggested the potential for further study. Read More

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September 2020

Evaluation of molecular analysis in challenging ovarian sex cord-stromal tumours: a review of 50 cases.

Pathology 2020 Oct 9;52(6):686-693. Epub 2020 Aug 9.

Department of Human Genetics, McGill University, Montréal, QC, Canada; Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montréal, QC, Canada; Research Institute of the McGill University Health Centre, Montréal, QC, Canada.

Molecular profiling was performed in 50 problematic ovarian sex cord-stromal tumours (SCSTs) most of which were seen in consultation. Following analysis, 17 were classified as adult granulosa cell tumour (AGCT), 16 of which showed a FOXL2 sequence variant (mutation); the initial favoured diagnosis in five of the cases was benign thecoma/fibrothecoma. Thirteen tumours ultimately classified as cellular fibroma or thecoma were FOXL2 sequence variant negative which was helpful in excluding AGCT. Read More

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October 2020

Progesterone-responsive vaginal leiomyoma and hyperprogesteronemia due to ovarian luteoma in an older bitch.

BMC Vet Res 2020 Aug 10;16(1):284. Epub 2020 Aug 10.

Department of Animal Medicine, Production and Health, University of Padua, Padua, Italy.

Background: This is the first report about a vaginal leiomyoma concomitant with an ovarian luteoma in a bitch.

Case Presentation: A 11-year-old intact female Labrador retriever was referred because of anuria, constipation and protrusion of a vaginal mass through the vulvar commissure. The bitch had high serum progesterone concentration (4. Read More

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Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman.

Diagnostics (Basel) 2020 Jul 30;10(8). Epub 2020 Jul 30.

Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

Ovarian gynandroblastoma (GAB) is an extremely rare sex cord-stromal tumor showing morphological evidence of both female (granulosa cell tumor) and male (Sertoli-Leydig cell tumor (SLCT)) components. Almost all GAB cases have been reported in children, adolescents, or women of reproductive age, and most of them typically have adult granulosa cell tumors as the female component. In contrast, GAB with a juvenile granulosa cell tumor (JGCT) component is a very rare condition; to the best of our knowledge, only one case of GAB with JGCT in a postmenopausal woman has been reported. Read More

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Metachronous Contralateral Cystadenoma After Ovariectomy for Juvenile Granulosa Cell Tumor in a Young Girl: An Uncommon Association.

J Pediatr Adolesc Gynecol 2021 Feb 1;34(1):103-105. Epub 2020 Aug 1.

Pediatric Surgery, Department of Women's and Children's Health, University Hospital of Padua, Padua, Italy. Electronic address:

Background: A unique Case of metachronous contralateral cystadenoma diagnosed 2 years after a juvenile granulosa cell tumor (JGCT) of the ovary is reported.

Case: One year after a left ovariectomy for JGCT, a 7 year-old girl was found to have, during her standard ultrasound follow-up, a 18-mm cyst in the right ovary, which was initially considered to be a follicular cyst. Six months later, the mass appeared to be increased and characterized by multivacuolar features, and inhibin A was mildly elevated. Read More

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February 2021

Epidemiology of ovarian cancer.

Chin Clin Oncol 2020 Aug 30;9(4):47. Epub 2020 Jun 30.

Department of Surgery, Section of Gynecology, National Institute of Medical Sciences and Nutrition "Salvador Zubirán", Mexico City, Mexico.

Worldwide, ovarian cancer (OC) is the seventh most common type of malignant neoplasm in women and the eighth cause of mortality in them. The classification of OC is made by the possible origin of one of the three main components of the ovary: epithelium, stroma, and germinal cells. Due to this the main malignant tumors arising from the ovary are epithelial carcinoma, germ cell tumor, sex cord-stromal tumor, and Krukenberg's tumor. Read More

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The Pathognomonic FOXL2 C134W Mutation Alters DNA-Binding Specificity.

Cancer Res 2020 09 8;80(17):3480-3491. Epub 2020 Jul 8.

Department of Microbiology and Immunology, Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.

The somatic missense point mutation c.402C>G (p.C134W) in the FOXL2 transcription factor is pathognomonic for adult-type granulosa cell tumors (AGCT) and a diagnostic marker for this tumor type. Read More

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September 2020

Mutant FOXL2 Hijacks SMAD4 and SMAD2/3 to Drive Adult Granulosa Cell Tumors.

Cancer Res 2020 09 8;80(17):3466-3479. Epub 2020 Jul 8.

Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen N, Denmark.

The mutant protein FOXL2 is expressed in at least 95% of adult-type ovarian granulosa cell tumors (AGCT) and is considered to be a driver of oncogenesis in this disease. However, the molecular mechanism by which FOXL2 contributes to tumorigenesis is not known. Here, we show that mutant FOXL2 acquires the ability to bind SMAD4, forming a FOXL2/SMAD4/SMAD2/3 complex that binds a novel hybrid DNA motif AGHCAHAA, unique to the FOXL2 mutant. Read More

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September 2020

Sertoli-Leydig cell tumor in two siblings with DICER1 syndrome: A case report and literature review.

Medicine (Baltimore) 2020 Jul;99(27):e20806

Department of Cancer Center.

Rationale: DICER1 syndrome is an autosomal-dominant tumor predisposition syndrome associated with numerous cancerous and noncancerous conditions. The most common sex cord-stromal tumor associated with DICER1 syndrome is Sertoli-Leydig cell tumor of the ovary (SLCT), which is extremely unusual and accounts for < 0.5% of all ovarian neoplasms. Read More

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Juvenile Granulosa Cell Tumors of the Ovary.

Am J Clin Pathol 2020 10;154(5):635-644

Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.

Objective: To explore the clinical and pathologic features of ovarian juvenile granulosa cell tumors (JGCTs).

Methods: Clinical data, histopathologic observations, immunohistochemical results, FOXL2 mutation status, and follow-up information of 7 JGCT cases were studied.

Results: The patients most commonly presented with abdominal distension and pain (5 cases), followed by precocious puberty (1 case) and a pelvic mass (1 case). Read More

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October 2020

Clinical Characteristics and Mutation Analyses of Ovarian Sertoli-Leydig Cell Tumors.

Oncologist 2020 09 11;25(9):e1396-e1405. Epub 2020 Aug 11.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Background: There are limited studies on Sertoli-Leydig cell tumors (SLCTs) and no data in the population of Chinese patients with SLCTs from the genetic level. In addition, previous studies on SLCTs have focused exclusively on mutations in the DICER1 gene and no data exists on the genetic landscape of SLCTs.

Methods: Patients with moderately or poorly differentiated SLCTs who underwent surgical resection between January 2012 and October 2018 in our institution were recruited. Read More

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September 2020

Ovarian Sertoli-Leydig and granulosa cell tumor: comparison of epidemiology and survival outcomes.

Arch Gynecol Obstet 2020 08 9;302(2):481-486. Epub 2020 Jun 9.

Department of Obstetrics and Gynecology, Helen O'Dickens Women's Health Center, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, USA.

Purpose: To investigate the epidemiology, clinico-pathological characteristics and outcomes of patients diagnosed with malignant ovarian Sertoli-Leydig cell tumors (SLCTs) in comparison to granulosa cell tumors (GCTs).

Methods: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database were accessed and patients diagnosed with a malignant SLCT and GCT between 1988 and 2013 were selected. Demographic and clinico-pathological characteristics were compared using the Mann-Whitney and chi-square tests. Read More

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