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Tech Vasc Interv Radiol 2021 Mar 15;24(1):100733. Epub 2021 Apr 15.

Assistant Professor, Department of Interventional Radiology, Massachusetts General Hospital, Boston, MA. Electronic address:

Iliac vein stenosis is a clinical condition resulting from external compression of the iliocaval venous unit with the consequent remodeling of the vascular wall, hemodynamic alterations, and predisposition to venous thrombosis. As such, the most common indications for percutaneous endovascular iliac vein stenting supported by the literature, include the management of thrombotic and non-thrombotic iliac venous lesions associated with advanced chronic venous disease (CVD). However, its clinical presentation is variable, and it may also include features associated with PeVD such as chronic pelvic pain, perineal heaviness, urinary urgency, postcoital pain, and vulvar or superficial non-saphenous veins varicosities. Read More

Ann Med 2021 Dec;53(1):908-915

Department of Medical and Surgical Sciences for Mother, Child and Adult, Azienda Ospedaliero-Universitaria di Modena, University of Modena and Reggio Emilia, Modena, Italy.

Introduction: To evaluate the actual perceptions of hormonal contraceptives (HC) in women of reproductive age in comparison with similar concerns of postmenopausal women in relation to hormone therapy (HT).

Materials And Methods: A questionnaire-based study was conducted in a population of 370 women, 198 (53.5%) premenopausal and 172 (46. Read More

Eur Heart J Case Rep 2021 Apr 21;5(4):ytab120. Epub 2021 Apr 21.

Department of cardiology, Heart Centre OLVG, Oosterparkstraat 9, 1091 AC Amsterdam, the Netherlands.

Background: Non-bacterial thrombotic endocarditis (NBTE) is a rare form of endocarditis notably described in patients with advanced malignancy and auto-immune diseases. It is characterized by the formation of sterile, fibrin-containing vegetations on cardiac endothelium, in the absence of positive blood cultures. It is predominantly located on the mitral- and aortic valve (AV). Read More

Respirol Case Rep 2021 Jul 31;9(7):e00795. Epub 2021 May 31.

Department of Cardiovascular Surgery Showa General Hospital Tokyo Japan.

Ovarian vein thrombosis (OVT) is observed in the field of obstetrics and gynaecology. It is occasionally diagnosed during the postpartum period or in patients with ovarian malignancy. Few cases of pulmonary thromboembolism (PTE) caused by OVT have been reported previously. Read More

World J Surg Oncol 2021 Jun 5;19(1):164. Epub 2021 Jun 5.

Department of Pathology, AIIMS, New Delhi, India.

Background: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has recently emerged as a viable management option for peritoneal surface malignancy (PSM). CRS and HIPEC is a complex, multidisciplinary and resource-intensive surgical procedure. It has a steep learning curve and is associated with significant morbidity and mortality. Read More

Medicine (Baltimore) 2021 Jun;100(22):e26152

Department of Anesthesiology and Pain Medicine, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, Korea.

Rationale: Patients with cancer have elevated risk of both venous thromboembolism and bleeding compared with patients without cancer due to cancer- and patient-specific factors. Balancing the increased and competing risks of clotting and bleeding in these patients can be difficult because management of cancer-associated thrombosis requires anticoagulation despite its known increased risks for bleeding. The adjustment of blood transfusion or cessation of anticoagulants can be a challenge in surgical diagnosis or treatment of cancer patients with such an imbalanced coagulate status. Read More

Exp Clin Transplant 2021 06 3. Epub 2021 Jun 3.

From the Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Portal vein thrombosis is a common complication in patients with cirrhosis and a challenge for the transplant team. Not so long ago, portal vein thrombosis was considered an absolute contraindication for liver transplant, but improvements in surgical techniques have overcome this problem in many transplant centers around the world. Here, we present the case of a 52-year-old female patient with cirrhosis from a primary biliary cholangitis and a complex portal vein thrombosis. Read More

Zhonghua Fu Chan Ke Za Zhi 2021 May;56(5):341-348

Department of Gynecology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To investigate the occurrence and influencing factors of perioperative complications after robotic gynecologic surgery. The clinical data and occurrence of perioperative complications in 1 000 cases robotic surgery completed in the First Affiliated Hospital of Zhengzhou University were retrospectively analyzed. (1) Clinical data: the average age of the patients was (50. Read More

Int J Surg Case Rep 2021 May 12;83:105975. Epub 2021 May 12.

Department of Surgery, Golestan University of Medical Sciences, Iran. Electronic address:

Introduction And Importance: Ovarian vein thrombosis (OVT) is exceedingly rare, which commonly occurs in postpartum patients and can result in serious complication such as pulmonary emboli. With a presentation often mimicking that of acute abdomen, it can be often misdiagnosed and mistreated.

Case Presentation: A 30-year-old woman referred with right lower quadrant abdominal pain, nausea and anorexia, one week after normal vaginal delivery. Read More

Qatar Med J 2021 30;2021(1):13. Epub 2021 Apr 30.

Department of Medicine, Hamad General Hospital, Doha, Qatar E-mail:

Background: Ovarian vein thrombosis (OVT) commonly occurs during the peripartum and postpartum period. However, few cases of idiopathic OVT unrelated to pregnancy have been described.

Case Report: We report a case of a previously healthy, 32-year-old female who presented with chronic right-sided abdominal pain. Read More

Thromb Res 2021 07 8;203:90-92. Epub 2021 May 8.

Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke, Japan.

J Surg Oncol 2021 Jul 29;124(1):106-114. Epub 2021 Apr 29.

Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.

Objective: We aimed to evaluate the prevalence of pulmonary embolism (PE) before cancer therapies in patients with ovarian and endometrial cancers with enhanced computed tomography (CT) using D-dimer (DD), and determine the optimal cut-off level of DD.

Methods: Since 2009, we have performed preoperative venous thromboembolism (VTE) screening of patients with ovarian and endometrial cancer. For patients with DD levels of more than 1. Read More

Sci Adv 2021 Apr 28;7(18). Epub 2021 Apr 28.

Institute of Women's Life Medical Science, Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

The regeneration potential of implantable organ model hydrogels is applied to treat a loss of ovarian endocrine function in women experiencing menopause and/or cancer therapy. A rat ovariectomy model is used to harvest autologous ovary cells while subsequently producing a layer-by-layer form of follicle spheroids. Implantation of a microchannel network hydrogel with cell spheroids [vascularized hydrogel with ovarian spheroids (VHOS)] into an ischemic hindlimb of ovariectomized rats significantly aids the recovery of endocrine function with hormone release, leading to full endometrium regeneration. Read More

BMJ Case Rep 2021 Apr 9;14(4). Epub 2021 Apr 9.

College of Medicine, Florida State University, Sarasota, Florida, USA.

A healthy 32-year-old G3P3 woman with an unknown last menstrual period presented to the emergency department with intense abdominal pain and pain in the right chest that radiated down the right arm. Further workup showed that she had a ruptured ectopic pregnancy with significant haemoperitoneum. After successful laparoscopic evacuation of the ectopic pregnancy and haemoperitoneum, the patient subsequently developed a right ovarian vein thrombosis 4 weeks after the procedure. Read More

Cancers (Basel) 2021 Mar 2;13(5). Epub 2021 Mar 2.

Department of Internal Medicine, Division of Hematology/Oncology, American University of Beirut, Beirut 1107 2020, Lebanon.

Background: The role and effect of radiotherapy in the development of VTE has not been extensively explored; Methods: This is a post-hoc analysis from the COMPASS-CAT trial. Patients with breast, lung, colon or ovarian cancer, with early, locally advanced or metastatic disease and receiving chemotherapy were included. Primary endpoint was documented symptomatic VTE; Results: A total of 1355 patients were enrolled between November 2013 and November 2015. Read More

J Thromb Thrombolysis 2021 Mar 31. Epub 2021 Mar 31.

Department of Cardiology, Mohammed VI University of Health Sciences (UM6SS), Cheick Khalifa International University Hospital, Mohamed Taieb Naciri Avenue, Hay Hassani, 82403, Casablanca, Morocco.

Coronavirus is a source of deep venous thrombosis (DVT) due to complications such as over-coagulation, blood stasis, and endothelial damage. Ovarian vein thrombosis (OVT) is a very serious and rare disease. In this study, we report tow rare case of women with coronavirus who were hospitalized with a right ovarian vein thrombosis mimicking acute abdomen who progressed well on anticoagulation. Read More

Ann Palliat Med 2021 Mar 17;10(3):3504-3509. Epub 2021 Mar 17.

Department of Radiology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.

Ovarian hyperstimulation syndrome (OHSS) is a rare but serious complication of assisted reproductive technology application. The incidence of stroke symptoms associated with OHSS is lower than that of abdominal symptoms, which may occur in severe OHSS situation. If tissue plasminogen activator (tPA) is not applicable, mechanical thrombectomy (MT) is recommended for acute cerebral artery occlusion within 6 hours of symptom onset according to the current guidelines. Read More

Res Pract Thromb Haemost 2021 Feb 28;5(2):265-277. Epub 2021 Jan 28.

Department of Medicine and Surgery University of Insubria Varese Italy.

Direct oral anticoagulants (DOACs) are currently the preferred oral anticoagulant treatment for most of the patients with deep vein thrombosis of the lower extremities and/or pulmonary embolism. DOACs have several advantages over vitamin K antagonists, such as availability of fixed dosages, fewer drug interactions, faster onset of action, shorter half-life, and lower risk of major and intracranial bleeding. Although the evidence on the use of DOACs in patients with unusual-site venous thromboembolism (VTE) is limited to a few, small randomized controlled trials, these drugs are increasingly used in clinical practice, and several observational cohort studies have been published recently. Read More

BMJ Case Rep 2021 Mar 16;14(3). Epub 2021 Mar 16.

Obstetrics and Gynaecology, Southend University Hospital NHS Foundation trust, Westcliff On Sea, UK.

We present a case of a giant ovarian cyst in a 20-year-old woman who presented atypically at our Emergency Department with left-sided back pain followed by acute left leg swelling. Blood tests showed significantly raised C-Reactive Protein and D-Dimer. CT-Abdomen-Pelvis demonstrated a large mass in the region of the right ovary with suspicious heterogeneous filling defects in the left external iliac vein, confirmed as a left-sided deep-vein thrombosis on ultrasound Doppler. Read More

Taiwan J Obstet Gynecol 2021 Mar;60(2):367-369

Department of Obstetrics and Gynecology, Collage of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Objective: The aim of this report is to highlight the importance of a comprehensive preoperative evaluation in the case of intravenous leiomyomatosis.

Case Report: A 49-year-old women was presented with dyspnea and abdominal distension. Imaging studies revealed a large leiomyoma with intravenous leiomyomatosis from this mass to the right parauterine veins, right ovarian vein reaching the inferior vena cava. Read More

Medicine (Baltimore) 2021 Feb;100(8):e24632

Department of Emergency Medicine.

Rationale: Postpartum ovarian vein thrombophlebitis (POVT) is a rare condition, and it can lead to severe complications and mortality. Here we report a patient who presented with vaginal bleeding and the diagnosis of POVT was confirmed by imaging.

Patient Concerns: A 38-year-old postpartum woman without remarkable medical history presented with vaginal bleeding and lower abdominal pain. Read More

Cureus 2021 Jan 20;13(1):e12796. Epub 2021 Jan 20.

Internal Medicine, Reading Hospital Tower Health, Reading, USA.

Ovarian vein thrombosis is a rare condition associated with the postpartum state, pelvic disease, gynecological surgeries, and other thrombophilic states. We present the first reported case of right ovarian vein thrombosis (OVT) in the setting of Coronavirus disease 2019 (COVID-19) unrelated to pregnancy, pelvic disease, or surgery. This case highlights the breadth of the hypercoagulable state induced by COVID-19. Read More

BMJ Case Rep 2021 Feb 23;14(2). Epub 2021 Feb 23.

Internal Medicine, McLaren Regional Medical Center, Flint, Michigan, USA.

Ovarian vein thrombosis (OVT) is a condition most commonly associated with malignancy, hypercoagulable disorders, pelvic surgery, trauma, inflammatory bowel disease and the postpartum period. Idiopathic bilateral OVT is extremely rare. We report the case of a 30-year-old African-American woman who presented with bilateral lower pelvic pain and nausea. Read More

Clin Appl Thromb Hemost 2021 Jan-Dec;27:1076029620975484

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT) occurs more frequently in cancer patients than in the general population. A retrospective cross-sectional study was carried out in patients with solid tumor complicated with VTE admitted to the Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology between January 1st, 2008 and December 31th, 2017. The incidence of VTE in hospitalized cancer patients was 1. Read More

Ceska Gynekol 2020 ;85(4):254-258

Objective: An analysis of POVT (postpartum ovarian vein thrombosis) case, the importance of prompt diagnosis, antibiotic and anticoagulation therapy management with multidisciplinary team approach.

Design: A case report and literature review.

Setting: 1st Department of Gynaecology and Obstetrics, Faculty of Medicine Comenius University and University Hospital, Bratislava, Slovakia. Read More

Pathol Int 2021 Apr 9;71(4):261-266. Epub 2021 Feb 9.

Department of Diagnostic Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

Ovarian cancer is a known risk factor of venous thromboembolism (VTE). Thrombogenic factor expression and lymphocytic infiltrate have been reported in endometriosis and ovarian cancers. We reviewed 30 cases of ovarian carcinomas (high grade serous carcinoma, 10; endometrioid carcinoma, 10; clear cell carcinoma (CCC), 10) and 16 endometriotic lesions. Read More

J Thromb Thrombolysis 2021 May 4;51(4):1059-1066. Epub 2021 Feb 4.

Gonda Vascular Center, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Distal or calf deep vein thrombosis (DVT) are said to have low rates of propagation, embolization, and recurrence. The objective of this study was to determine outcomes among cancer patients with calf DVT compared to those without cancer. Consecutive patients with ultrasound confirmed acute calf DVT (3/1/2013-8/10/2019) were assessed for venous thromboembolism (VTE) recurrence and bleeding outcomes compared by cancer status. Read More

Taiwan J Obstet Gynecol 2021 Jan;60(1):148-151

Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

Objective: The risk of venous thromboembolism in pregnancies increased in ovarian hyperstimulation syndrome (OHSS) after assisted reproductive technologies (ART). We present a rare case with protein S deficiency receiving ART treatment with OHSS, following right neck venous thromboembolism.

Case Report: A 34-year-old women with primary infertility underwent IVF treatment and presented with OHSS. Read More

Int J Mol Sci 2021 Jan 14;22(2). Epub 2021 Jan 14.

Clinic for Hematology and Oncology, University Hospital and Medical School (UKSH), University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany.

The development of malignant effusions such as ascites reflects a massive progression of a malignant disease. In patients with ovarian carcinoma, a high amount of ascites (>500 mL) is an independent negative prognostic marker. The composition and constituents of ascites reflect the inflammatory environment of the underlying tumor. Read More

Zhejiang Da Xue Xue Bao Yi Xue Ban 2020 Dec;49(6):772-778

Department of Respiratory Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, National Regional Medical Center for Respiratory Diseases, Hangzhou 310016, China.

Malignant tumor is one of the important acquired risk factors of venous thromboembolism (VTE). As the transmembrane receptor of coagulation factor Ⅶ and activated coagulation factor Ⅶa , tissue factor is the main initiator of exogenous coagulation. Tissue factor positive particles expressed and released by tumor cells enter the circulation and mediate thrombosis in patients with surgical treatment and distant tumor metastasis; the enhanced procoagulant activity of tissue factor after chemotherapy makes many cancer patients more likely to develop thromboembolic disease. Read More