187,554 results match your criteria Ovarian Vein Thrombosis


Cumulative live birth rate prognosis based on the number of aspirated oocytes in previous ART cycles.

Hum Reprod 2018 Dec 12. Epub 2018 Dec 12.

Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Kettegård Allé 26, Hvidovre, Denmark.

Study Question: Is the number of aspirated oocytes in the first ART cycle associated with the cumulative live birthrates (CLBR) in subsequent cycles?

Summary Answer: The number of aspirated oocytes in the first cycle was associated with CLBR in subsequent cycles. Previous treatment response predicts outcome in future cycles.

What Is Known Already: Previous reports have shown a positive association between the number of retrieved oocytes and live birthrate per fresh treatment cycle. Read More

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December 2018

DNA damage and repair in the female germline: contributions to ART.

Hum Reprod Update 2018 Dec 12. Epub 2018 Dec 12.

Priority Research Centre for Reproductive Science, Discipline of Biological Sciences, University of Newcastle, Callaghan, NSW, Australia.

Background: DNA integrity and stability are critical determinants of cell viability. This is especially true in the female germline, wherein DNA integrity underpins successful conception, embryonic development, pregnancy and the production of healthy offspring. However, DNA is not inert; rather, it is subject to assault from various environment factors resulting in chemical modification and/or strand breakage. Read More

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December 2018

PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer.

Cell Rep 2018 Dec;25(11):2972-2980.e5

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

PARP inhibitors have shown promising clinical activities for patients with BRCA mutations and are changing the landscape of ovarian cancer treatment. However, the therapeutic mechanisms of action for PARP inhibition in the interaction of tumors with the tumor microenvironment and the host immune system remain unclear. We find that PARP inhibition by olaparib triggers robust local and systemic antitumor immunity involving both adaptive and innate immune responses through a STING-dependent antitumor immune response in mice bearing Brca1-deficient ovarian tumors. Read More

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December 2018
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[Oral contraception and the risk of breast cancer. Review of the literature].

Magy Onkol 2018 Dec 10;62(4):258-263. Epub 2018 Sep 10.

Uzsoki Utcai Kórház, Fõvárosi Onkoradiológiai Központ, Budapest, Hungary.

At present an estimated hundred millions of women worldwide use oral contraception, but the influence of hormonal contraception on carcinogenesis of breast is not fully understood. Previous studies of breast cancer risk show inconsistent findings - from zero elevation to approximately 30%-40% increase in risk. The beneficial effect on ovarian and endometrial cancer risk is apparent. Read More

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December 2018

Lower circulating levels of CTRP12 and CTRP13 in polycystic ovarian syndrome: Irrespective of obesity.

PLoS One 2018 12;13(12):e0208059. Epub 2018 Dec 12.

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Altered production of adipokines is suggested to play a pivotal role in the pathogenesis of polycystic ovarian syndrome (PCOS). C1q/TNF-related proteins (CTRPs) play diverse roles in regulation of metabolism in physiologic and pathologic conditions. In the present study, we assessed serum concentrations of adiponectin, CTRP12, and CTRP13 in individuals with PCOS and those without PCOS. Read More

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December 2018

Cell-based immunotherapy in gynecologic malignancies.

Curr Opin Obstet Gynecol 2018 Dec 11. Epub 2018 Dec 11.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford Women's Cancer Center, Stanford University School of Medicine, Stanford, California, USA.

Purpose Of Review: To provide an update on cell-based immunotherapies in solid tumors particularly in gynecological cancers.

Recent Findings: Improvements have been made in engineering T cells to overcome the immunosuppressive environment in ovarian cancer. Significant efforts are underway to create 'off the shelf' cell therapies which leverage natural killer (NK) cells and would not rely on engineering a patient's T cells. Read More

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December 2018

Poly-ADP-ribosyl-polymerase inhibitor resistance mechanisms and their therapeutic implications.

Authors:
Kelly E McCann

Curr Opin Obstet Gynecol 2018 Dec 11. Epub 2018 Dec 11.

David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.

Purpose Of Review: Poly-ADP-ribosyl-polymerase (PARP) inhibitors are an increasingly-utilized therapy in women with high-grade serous ovarian carcinoma, but tumor resistance to PARP inhibitor monotherapy is inevitable.

Recent Findings: PARP inhibitors have been most studied in patients with breast and ovarian cancers associated with deleterious germline BRCA1 or BRCA2 mutations, though their role has expanded to include use as maintenance therapy in women with platinum-sensitive high-grade serous ovarian cancer due to the high propensity of such cancers to have defects in DNA repair by homologous recombination. As mechanisms of PARP inhibitor resistance are elucidated, rationale combination strategies can be devised to extend therapeutic benefits and to abrogate resistance. Read More

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December 2018

Activin A in Mammalian Physiology.

Physiol Rev 2019 Jan;99(1):739-780

Department of Morphology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche , Ancona , Italy ; Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena , Siena , Italy ; and Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital , Florence , Italy.

Activins are dimeric glycoproteins belonging to the transforming growth factor beta superfamily and resulting from the assembly of two beta subunits, which may also be combined with alpha subunits to form inhibins. Activins were discovered in 1986 following the isolation of inhibins from porcine follicular fluid, and were characterized as ovarian hormones that stimulate follicle stimulating hormone (FSH) release by the pituitary gland. In particular, activin A was shown to be the isoform of greater physiological importance in humans. Read More

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January 2019

Synthesis and characterization of cyclohexane-1R,2R-diamine-based Pt(iv) dicarboxylato anticancer prodrugs: their selective activity against human colon cancer cell lines.

Dalton Trans 2018 Dec 12. Epub 2018 Dec 12.

Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Viale Michel 11, 15121 Alessandria, Italy.

Three pairs of asymmetric dicarboxylato derivatives based on the cisplatin and oxaliplatin-like skeletons have been synthesized de novo or re-synthesized. The axial ligands consist of one medium-chain fatty acid (MCFA), namely clofibrate (i.e. Read More

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December 2018

Uterine tumors resembling ovarian sex-cord tumor: A case report and literature review.

J Cancer Res Ther 2018 Dec;14(Supplement):S1209-S1212

Department of Obstetrics and Gynaecology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.

Uterine tumors resembling ovarian sex-cord tumor (UTROSCT) are a rare, multi-phenotype sex-cord tumors, containing a structure which is characteristic with the trabecular, cord, nests, and false adenoid arrangement. In addition, CD99-positive was a basis for diagnosis of the disease. With uncertain malignant potential and relapse, these patients should be closely followed up. Read More

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December 2018

The nucleolar transcriptome regulates Piwi shuttling between the nucleolus and the nucleoplasm.

Chromosome Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Molecular Genetics of the Cell, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow, Russian Federation, 123182.

The nucleolus contains a lot of proteins unrelated to ribosome biogenesis. Some of these proteins shuttle between the nucleolus and the nucleoplasm regulating the cell cycle and stress response. The piRNA binding protein Piwi is involved in silencing of transposable elements (TEs) in the Drosophila gonads. Read More

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December 2018

A retrospective analysis of the follicle-stimulating hormone starting dose in expected normal responders undergoing their first fertilization cycle: proposed dose versus empiric dose.

Clin Exp Reprod Med 2018 Dec 30;45(4):183-188. Epub 2018 Nov 30.

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.

Objective: The purpose of this retrospective study was to evaluate the appropriateness of various follicle-stimulating hormone (FSH) starting doses in expected normal responders based on the nomogram developed by La Marca et al.

Methods: A total of 117 first fertilization cycles performed from 2011 to 2017 were selected. All women were expected normal responders and used a recombinant FSH and flexible gonadotropin-releasing hormone antagonist protocol. Read More

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December 2018

An Unusual Adenomatoid Tumor of Fimbria with Pronounced Psammoma Bodies in a BRCA Positive Patient as a Pitfall for Carcinoma on Frozen Section.

Case Rep Pathol 2018 21;2018:8148147. Epub 2018 Nov 21.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Background: BRCA gene mutations significantly increase the risk of breast and ovarian cancers where the lifetime risk of the ovarian cancer is about 40%. Therefore, many women with such mutations undergo prophylactic bilateral mastectomy and salpingo-oophorectomy. About 5-6% of these individuals display occult carcinomas in tubo-ovarian locations of which over 85% are tubal in origin. Read More

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November 2018

Successful pregnancy after uterine artery embolization for uterine arterovenous malformation: a rare case report.

Int J Womens Health 2018 21;10:745-750. Epub 2018 Nov 21.

Università degli studi di Salerno - Dipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana", Salerno, Italy,

Objective: This paper reports on a rare case of pregnancy after uterine artery embolization (UAE) for uterine arteriovenous malformation (AVM). Debate exists about persistence of fertility in women after UAE. Adverse effects of this technique can modify both uterine echostructure, inducing necrosis and infarction, endometrial atrophy and uterine artery rupture, and ovarian reserve, causing persistent amenorrhea. Read More

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November 2018

Glucose deprivation promotes apoptotic response to S1 by enhancing autophagy in human cervical cancer cells.

Cancer Manag Res 2018 23;10:6195-6204. Epub 2018 Nov 23.

Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, China,

Background: S1 is a novel BH3 mimetic that can induce death in some types of cancer cells, such as melanoma B16, ovarian cancer SKOV3, and U251 glioma cells. S1 inhibits Bcl-2 and Mcl-1 expression and induces cancer cell apoptosis. Cancer cell survival is highly dependent on glucose. Read More

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November 2018

Multiple Gastrointestinal Cancers in a Single Patient-a Rare Clinical Entity.

Indian J Surg Oncol 2018 Dec 16;9(4):633-635. Epub 2018 May 16.

Department of Surgical Oncology, BLK Hospital, Rajinder Place, New Delhi, 110008 India.

Multiple gastrointestinal cancers in a single patient is a rare entity. In our study, we are showing the clinical presentation and management of these patients. A fifty-nine-year-old asthenic male (already treated case of metachronous colorectal cancer in 2008 and 2011) presented with complaints of generalized weakness and fatigue. Read More

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December 2018

Occult Gallbladder Carcinoma Presenting as a Primary Ovarian Tumour: a Case Report and Review of Literature.

Indian J Surg Oncol 2018 Dec 20;9(4):618-621. Epub 2018 Jul 20.

1Department of Obstetrics and Gynaecology, K.S. Hegde Medical Academy, Mangalore, 575018 India.

The ovary is a common site of metastasis from various organs. However, little is known about gallbladder carcinoma metastasising to the ovaries and presenting as a primary ovarian tumour. We report a case of a metastatic gallbladder carcinoma which mimicked a primary ovarian tumour in a 31-year-old woman who presented with menstrual symptoms and an ovarian mass without obvious signs and symptoms related to gallbladder carcinoma. Read More

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December 2018

Different Presentations of Five Rare Cases of Sclerosing Stromal Tumor of the Ovary.

Indian J Surg Oncol 2018 Dec 19;9(4):581-584. Epub 2018 May 19.

1Obstetrics and Gynecology Department, Shiraz University of Medical Sciences, Shiraz, Iran.

A rare subtype of preceding neoplasm of ovary is sclerosing stromal cell tumor with few presented cases in the literature. In these case series, we describe five cases of ovarian sclerosing stromal cell tumor with different presentations in our department. Interestingly, one of our cases had elevated alfa-fetoprotein. Read More

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December 2018

Outcome of Bowel Resection in Women with Advanced Ovarian Carcinoma.

Indian J Surg Oncol 2018 Dec 20;9(4):511-518. Epub 2018 Jul 20.

1Department of Gynaecologic Oncology, CMC Hospital, Vellore, 632004 India.

To evaluate the mortality and morbidity related to bowel resection in women with advanced ovarian carcinoma. Retrospective case series of 47 women with stage III and IV carcinoma ovary who underwent bowel resection, over the period of 5 years from Jan 2011 to Dec 2015. The risk factors for perioperative morbidity and death were determined by regression analysis. Read More

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December 2018

Effect of synbiotic pomegranate juice on glycemic, sex hormone profile and anthropometric indices in PCOS: A randomized, triple blind, controlled trial.

Nutr Metab Cardiovasc Dis 2018 Jul 17. Epub 2018 Jul 17.

Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background And Aims: Polycystic Ovarian Syndrome is a common reproductive, endocrine, and metabolic disease in women. Pomegranate juice, known as a rich source of phytochemicals with high antioxidant activity, enriched with probiotic may improve PCOS.

Methods And Results: A randomized, controlled, triple-blinded, parallel trial study was performed in PCOS patients (n = 92). Read More

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Challenges in the identification of inherited risk of ovarian cancer: where should we go from here?

Gynecol Oncol 2018 Dec 8. Epub 2018 Dec 8.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, United States of America. Electronic address:

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December 2018

Legacies and Relationships: Diverse Social Networks and BRCA1/2 Risk Management Decisions and Actions.

J Fam Nurs 2018 Dec 12:1074840718815844. Epub 2018 Dec 12.

5 National Institutes of Health, Bethesda, MD, USA.

In families with hereditary breast/ovarian cancer, complex disease histories challenge established patterns of family communication and influence decision-making for clinical surveillance, genetic testing, and risk management. An interdisciplinary team examined longitudinal interview data from women with identified BRCA1/2 mutations to assess interactions within family and social networks about risk information communication and management. We used interpretive description to identify motivation, content, and derived benefit of these interactions. Read More

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December 2018

Quantum Dot-labeled Tags Improve Minimal Detection Limit of CA125 in Ovarian Cancer Cells and Tissues.

Iran J Allergy Asthma Immunol 2018 Aug 12;17(4):326-335. Epub 2018 Aug 12.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran AND Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran AND Immunology Research Center (IRC), Iran University of Medical Sciences, Tehran, Iran.

In recent years, a lot of attention has been paid to quantum dot (QD) nanoparticles as fluorescent sensors for sensitive and accurate detection of cancer biomarkers. Here, using a homemade specific monoclonal antibody against CA125 and QD525- or FITC-labeled probes, expression of this marker in an ovarian cancer cell line and cancer tissues were traced and optical properties of fluorophores were compared qualitatively and quantitatively. Our results clearly showed that besides lower background and exceptionally higher photobleaching resistance, QD525 exhibited higher fluorescent intensity for both ovarian cancer cell and tissues at different exposure times (p<0. Read More

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GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis.

Nat Commun 2018 12 6;9(1):5224. Epub 2018 Dec 6.

Department of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, 23538, Germany.

Autoantibodies have been associated with autoimmune diseases. However, studies have identified autoantibodies in healthy donors (HD) who do not develop autoimmune disorders. Here we provide evidence of a network of immunoglobulin G (IgG) autoantibodies targeting G protein-coupled receptors (GPCR) in HD compared to patients with systemic sclerosis, Alzheimer's disease, and ovarian cancer. Read More

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December 2018

Establishment of a Mouse Model of Premature Ovarian Failure Using Consecutive Superovulation.

Cell Physiol Biochem 2018 7;51(5):2341-2358. Epub 2018 Dec 7.

Key Laboratory of the Model Animal Research, Animal Core Facility of Nanjing Medical University, Nanjing Medical University, Nanjing,

Background/aims: This study investigated the effect of consecutive superovulation on the ovaries and established a premature ovarian failure (POF) model in mice.

Methods: The mouse POF model was induced by 5-15 consecutive superovulation treatments with pregnant mare serum gonadotropin (PMSG), human chorionic gonadotropin (HCG) and prostaglandin F2α (PGF2α). Normal adult mice were compared with mice displaying natural ovarian aging. Read More

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December 2018

Evaluation of porcine circovirus type 2 infection in in vitro embryo production using naturally infected oocytes.

Theriogenology 2018 Dec 4;126:75-80. Epub 2018 Dec 4.

Key Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin, 150030, Heilongjiang, PR China. Electronic address:

In vitro fertilization (IVF) and somatic cell nuclear transfer (SCNT) are important breeding techniques for livestock. High-quality MII oocytes produced from in vitro maturation (IVM) are required for the two techniques listed above. The ovaries used for IVM operations are primarily acquired from commercial abattoirs, and the pathogen status of slaughtered animals becomes an unavoidable issue. Read More

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December 2018

MiR-34c/SOX9 axis regulates the chemoresistance of ovarian cancer cell to cisplatin-based chemotherapy.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Department of Gynecology and Obstetrics, The Third Xiangya Hospital, Central South University, Changsha, China.

Cisplatin (DDP)-based chemotherapy is a standard strategy for ovarian cancer (OC), while chemoresistance remains a major therapeutic challenge. Transcription factor SOX9 has been reported to be associated with tumor cell proliferation, metastasis, and chemoresistance. In the current study, we observed a higher SOX9 expression in OC cell lines; SOX9 overexpression might aggravate the chemoresistance of the OC cell to DDP, whereas its knockdown enhanced the chemoresistance. Read More

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December 2018

Follicle Populations and Gene Expression Profiles of Nelore and Angus Heifers with Low and High Ovarian Follicle Counts.

Mol Reprod Dev 2018 Dec 8. Epub 2018 Dec 8.

Department of Pharmacology, , Institute of Biosciences, São Paulo State University (UNESP), Botucatu, Brazil.

The number of antral follicles counted by ultrasound (AFC) is associated with fertility in cattle. Cows with higher follicle count (HFC) have higher performance in reproductive-assisted technologies than cows with lower follicle count (LFC). In this study, we aimed to define the preantral follicle count by histology and to identify differentially expressed genes (DEGs) using a microarray in Nelore and Angus heifers with HFC and LFC. Read More

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December 2018

High expression of LASS2 is associated with unfavorable prognosis in patients with ovarian cancer.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.

Homo sapiens longevity assurance homolog 2 of yeast LAG1 (LASS2), is a gene isolated from a human liver complementary DNA library. In this study, we found that LASS2 protein level was positively related to International Federation of Gynecology and Obstetrics (FIGO) stage and LASS2-negative tumors showed significant association with longer disease-free survival (DFS) and overall survival (OS) in ovarian cancer patients. The heterogeneous expression of LASS2 had been exhibited in diverse ovarian cancer cells. Read More

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December 2018

Long noncoding RNA CASC9 promotes LIN7A expression via miR-758-3p to facilitate the malignancy of ovarian cancer.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Head and Neck and Genito-Urinary Oncology, Harbin Medical University Cancer Hospital, Harbin, China.

The long noncoding RNA cancer susceptibility 9 (CASC9) has been reported to be a pivot modulator in growth and metastasis of breast cancer, liver cancer, esophageal squamous cell carcinoma, lung adenocarcinoma, gastric cancer, and nasopharyngeal cancer. However, its potential roles in ovarian cancer remain unclear. In this study, we aimed at its functions and molecular mechanism in ovarian cancer progression. Read More

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December 2018

Activation of TGF-β1/Smad3 signaling pathway inhibits the development of ovarian follicle in polycystic ovary syndrome by promoting apoptosis of granulosa cells.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China.

Objective: To investigate the role of the transforming growth factor-β1 (TGF-β1)/Smad3 signaling pathway in development of ovarian follicle by promoting apoptosis of granulosa cells in polycystic ovary syndrome (PCOS).

Methods: A total of 54 female rats were obtained and randomly assigned into the PCOS (n = 27) and control groups ( n = 27). PCOS rat models were constructed using the dehydroepi-androsterone method to observe ovarian morphology and ultrastructure. Read More

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December 2018

Calcitonin administration improves endometrial receptivity via regulation of LIF, Muc-1 and microRNA Let-7a in mice.

J Cell Physiol 2018 Dec 8. Epub 2018 Dec 8.

Department of Reproductive Biology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Calcitonin (CT) is one of the factors affecting the embryo implantation, but its effects on the implantation window have not been fully investigated. The current study investigated the effects of CT on the endometrium receptivity by morphological study and evaluation of leukemia inhibitory factor (LIF), mucin 1 (Muc-1), and microRNA (miRNA) Let-7a in the ovarian stimulation and the normal ovarian cycle. Then the mechanism of the CT effects through the mammalian target of rapamycin (mTOR) signaling pathway was studied by using PP242. Read More

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December 2018

Insulin-like peptides of the legume pod borer, Maruca vitrata, and their mediation effects on hemolymph trehalose level, larval development, and adult reproduction.

Arch Insect Biochem Physiol 2018 Dec 10:e21524. Epub 2018 Dec 10.

Department of Plant Medicals, Andong National University, Andong, Korea.

Insulin-like peptides (ILPs) of insects mediate various physiological processes including hemolymph sugar level, immature growth, female reproduction, and lifespan. In target cells of ILPs, insulin/insulin-like growth factor signaling (IIS) is highly conserved in animals. IIS in the legume pod borer, Maruca vitrata (Lepidoptera: Crambidae), is known to be involved in maintaining hemolymph trehalose levels and promoting larval growth. Read More

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December 2018

Hypoxia-inducible factor-2α directly promotes BCRP expression and mediates the resistance of ovarian cancer stem cells to adriamycin.

Mol Oncol 2018 Dec 10. Epub 2018 Dec 10.

Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning Province, China.

Ovarian cancer stem cells (OCSCs) are sources of tumor chemoresistance and recurrence. A hypoxic microenvironment contributes to the chemoresistance of cancer stem cells (CSCs), but the underlying mechanism is not fully understood yet. Here, we show that increased HIF-2α expression is associated with enhanced stemness of OCSCs and poor outcomes in ovarian cancer patients. Read More

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December 2018

Response to Re: 'Neoadjuvant chemotherapy for advanced ovarian cancer. Who really benefits?'

Authors:
Neville F Hacker

Aust N Z J Obstet Gynaecol 2018 Dec;58(6):E26-E27

Gynaecological Cancer Centre Royal Hospital for Women Randwick, Australia.

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December 2018

Re: Neoadjuvant chemotherapy for advanced ovarian cancer. Who really benefits?

Aust N Z J Obstet Gynaecol 2018 Dec;58(6):E25-E26

The Sydney Gynaecologic Group, Chris O Brien Lifehouse, Camperdown, New South Wales, Australia.

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December 2018

Risk of cancer after assisted reproduction: a review of the available evidences and guidance to fertility counselors.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):8042-8059

Gynecological Oncology, National Cancer Institute, Aviano, Italy.

Objective: Infertile women requiring ovarian stimulation and assisted reproduction techniques (ART) are faced with difficult issues. The fear that using hormones could increase their risk of cancer is the most significant. One of the main challenges for assessing cancer risk after ART is the difficulty to separate it from the underlying condition of infertility per se. Read More

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November 2018

Effect of anti-mullerian hormone on stem cell factor in serum, follicular fluid and ovarian granular cells of polycystic ovarian syndrome patients.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7877-7882

Jinan Maternity and Child Health Care Hospital, Jinan, Shandong, China.

Objective: Polycystic ovarian syndrome (PCOS) is a common disorder in gynecological practice. Anti-mullerian hormone (AMH) and ovarian granular stem cell factor (SCF) participate in the occurrence and progression of PCOS. This study aimed to investigate the expression of AMH and SCF in PCOS patients and attempt to analyze the effect of AMH on SCF. Read More

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November 2018

Downregulation of miR-1294 associates with prognosis and tumor progression in epithelial ovarian cancer.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7646-7652

Department of Gynecology, Jiujiang Maternal and Child Health Care Hospital in Jiangxi Province, Jiujiang City, Jiangxi Province, PR. China.

Objective: Increasing evidence has revealed that microRNAs (miRNAs) act as key players in the regulation of tumor growth and metastasis in epithelial ovarian cancer (EOC). However, the clinical role and functional effects of miR-1294 in EOC remain unknown.

Patients And Methods: We examined the expression of miR-1294 in 69 cases of EOC tissues and cell lines by quantitative Real-time polymerase chain reaction (qRT-PCR). Read More

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November 2018

Risk Factors for Strangulated Ovarian Hernia in Female Infants: the Role of Ovarian Volume.

Curr Med Sci 2018 Dec 7;38(6):1032-1037. Epub 2018 Dec 7.

Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

The risk factors associated with strangulated ovarian hernia (SOH) in female patients (<1 year old) were identified. A retrospective analysis was conducted regarding the data from 2006 to 2017. The patients were divided into 2 groups: SOH group (n=9) and non-SOH group (n=23). Read More

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December 2018
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Using PARP Inhibitors in the Treatment of Patients With Ovarian Cancer.

Curr Treat Options Oncol 2018 Nov 15;19(12). Epub 2018 Nov 15.

Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, 1155 Herman Pressler Dr. CPB 6.3279, Houston, TX, 77030, USA.

Opinion Statement: Use of poly(ADP-ribose) polymerase (PARP) inhibitors has greatly increased over the past 5 years. With several new Food and Drug Administration (FDA) approvals, three PARP inhibitors have entered into standard of care treatment for epithelial ovarian cancer (including ovarian, fallopian tube, and primary peritoneal cancer). Olaparib and rucaparib currently have indications for treatment of recurrent BRCA mutant ovarian cancer. Read More

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November 2018

Description of Ovariectomy Protocol in Mice.

Methods Mol Biol 2019 ;1916:303-309

Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de São Paulo, Diadema, SP, Brazil.

Estrogen and ovarian function decline are relevant characteristics of menopause period. Numerous physiological, metabolic and immunological alterations in the female body occur in the menopause period and some of these changes remain uncertain. The animal model that mimics menopause phase is an important approach to better comprehend the biological process involved in this period of women life. Read More

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January 2019
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Mutation screening of TP53, CHEK2 and BRCA genes in patients at high risk for hereditary breast and ovarian cancer (HBOC) in Brazil.

Breast Cancer 2018 Dec 11. Epub 2018 Dec 11.

Universidade Federal de São João del Rei (UFSJ), 400 Sebastião Gonçalves Coelho Ave., Chanadour, Divinópolis, MG, 35501-296, Brazil.

Background: Few studies related to hereditary breast and ovarian cancer syndrome (HBOC) have been conducted in Brazil, and they are restricted to only small areas of the country. Here, we report the mutation profile of BRCA1/2, CHEK2 and TP53 genes in a cohort from Minas Gerais state.

Methods: These genes from 44 patients at high risk for HBOC were screened through high-resolution melting and/or sequencing. Read More

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December 2018

Association between interleukin‑33 and ovarian cancer.

Oncol Rep 2018 Dec 7. Epub 2018 Dec 7.

Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA.

Ovarian cancer is the leading cause of cancer‑ associated mortality in the female reproductive system. Interleukin (IL)‑33 and its receptor IL 1 receptor like 1 (also termed ST2) are expressed by many cell types including epithelial cells. The role of IL‑33 in the pathogenesis of neoplasia remains controversial. Read More

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December 2018

YWHAZ promotes ovarian cancer metastasis by modulating glycolysis.

Oncol Rep 2018 Dec 7. Epub 2018 Dec 7.

State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, P.R. China.

Ovarian cancer is one of the three most deadly gynecological cancers, with the highest mortality rate. As the main cause of death, metastasis is considered to be a crucial factor that reduces the survival time of ovarian carcinoma patients. YWHAZ (also known as 14‑3‑3ζ) influences diverse vital cellular processes such as metabolism, signal transduction, apoptosis and cell cycle regulation. Read More

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December 2018

The temporal relationship between cancer and adult onset anti-transcriptional intermediary factor 1 antibody-positive dermatomyositis.

Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.

Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.

Objectives: To characterize the 10 year relationship between anti-transcriptional intermediary factor 1 antibody (anti-TIF1-Ab) positivity and cancer onset in a large UK-based adult DM cohort.

Methods: Data from anti-TIF1-Ab-positive/-negative adults with verified diagnoses of DM from the UK Myositis Network register were analysed. Each patient was followed up until they developed cancer. Read More

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December 2018
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Hysterectomy uniquely impacts spatial memory in a rat model: A role for the non-pregnant uterus in cognitive processes.

Endocrinology 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychology, Arizona State University, Tempe, AZ.

Approximately one-third of women experience hysterectomy, or the surgical removal of the uterus, by age 60, with most surgeries occurring prior to the onset of natural menopause. The ovaries are retained in about half of these surgeries while, for the other half, hysterectomy occurs concurrently with oophorectomy. The dogma is that the non-pregnant uterus is dormant. Read More

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December 2018

Advantages of Serum Anti-Müllerian Hormone as a Marker for Polycystic Ovarian Syndrome.

Lab Med 2018 Dec 10. Epub 2018 Dec 10.

Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Objective: To evaluate the advantages of using anti-Müllerian hormone (AMH) in the diagnosis of polycystic ovary syndrome (PCOS).

Methods: We compared data from 56 Han Chinese patients with PCOS and 52 female control Han Chinese individuals in terms of biochemical markers and the antral follicle count (AFC). Then, the correlation between serum AMH levels and various endocrine and metabolic factors was analyzed. Read More

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December 2018

Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort.

Hum Mol Genet 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.

The macula, located near the center of the retina in the human eye, is responsible for providing critical functions, such as central, sharp vision. Structural changes in the macula are associated with many ocular diseases, including age-related macular degeneration (AMD) and glaucoma. Although macular thickness is a highly heritable trait, there are no prior reported genome-wide association studies (GWASs) of it. Read More

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December 2018