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Surg Neurol Int 2020 30;11:128. Epub 2020 May 30.

Department of Neurosurgery, Kanazawa Medical Center, Shimoishibikimachi, Kanazawa, Ishikawa, Japan.

Background: Reversible cerebral vasoconstriction syndrome (RCVS) presents with characteristic clinical, brain imaging, and angiographic findings. The most common clinical feature of RCVS is a severe acute headache, which is often referred to as a thunderclap headache due to the nature of its presentation. It may occur spontaneously or may be provoked by various precipitating factors. Read More

J Thromb Thrombolysis 2020 Jun 8. Epub 2020 Jun 8.

Department of Anatomical Sciences, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Corona virus outbreak started in December 2019, and the disease has been defined by the World Health Organization as a public health emergency. Coronavirus is a source of deep venous thrombosis (DVT) due to complications such as over-coagulation, blood stasis, and endothelial damage. In this study, we report a 26-year-old pregnant woman with coronavirus who was hospitalized with a right ovarian vein thrombosis at Besat Hospital in Sanandaj. Read More

J Int Med Res 2020 Jun;48(6):300060520926742

Department of Gynecology & Obstetrics, Zhongshan Hospital, Fudan University, Shanghai, China.

Patients with ovarian cancer are often in a hypercoagulable state and have a high risk of venous thrombosis, including deep vein thrombosis and pulmonary embolism. However, arterial thrombosis is relatively rare in ovarian cancer. We report a case a 46-year-old woman with ovarian clear cell carcinoma who developed arterial and venous thrombosis in the lower extremities as the first manifestation. Read More

JA Clin Rep 2020 May 9;6(1):32. Epub 2020 May 9.

Department of Anesthesia, Japanese Red Cross Shizuoka Hospital, 8-2 Oute-machi Aoi-ku, Shizuoka, 420-0853, Japan.

Background: Trousseau's syndrome, also known as cancer-associated thrombosis, has several perioperative considerations, including the timing of surgery, anticoagulant therapy, and anesthetic technique. While appropriate anesthetic management is critical, few clinical reports have addressed the issue. Here, we report a patient with Trousseau's syndrome who successfully underwent gynecological surgery 1 month after a massive cerebral infarction. Read More

Thromb Res 2020 Jun 4;190:129-134. Epub 2020 Mar 4.

Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. Electronic address:

Introduction: To determine the incidence and predisposing factors of preoperative venous thromboembolism (VTE), especially pulmonary embolism (PE) in patients with ovarian cancer.

Material And Methods: This retrospective study included 387 patients with primary ovarian cancer, whose preoperative work up included both ultrasonography of lower extremity vein and spiral computed tomography pulmonary angiogram, from September 2013 to November 2016. SPSS 22 was used for statistical analyses. Read More

Biomed Res Int 2020 14;2020:9758302. Epub 2020 Feb 14.

Department of Vascular Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.

Purpose: This study aimed to retrospectively review the diagnosis and surgical treatment of uterine intravenous leiomyomatosis (IVL).

Methods: The clinical data of 14 patients with uterine IVL admitted to our hospital between 2013 and 2018 were retrospectively analyzed, including their demographics, imaging results, surgical procedures, perioperative complications, and follow-up results.

Results: The tumors were confined to the pelvic cavity in 7 patients, 1 into the inferior vena cava, 4 into the right atrium, and 2 into the pulmonary artery (including 1 into the superior vena cava). Read More

Case Rep Oncol 2020 Jan-Apr;13(1):239-244. Epub 2020 Mar 19.

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.

Nonbacterial thrombotic endocarditis (NBTE) is a rare entity most commonly diagnosed postmortem with rates in autopsy series ranging from 0.9 to 1.6%. Read More

Int J Gynecol Cancer 2020 Jun 9;30(6):860-864. Epub 2020 Apr 9.

Obstetrics and Gynecology, Tottori University, Yonago, Tottori, Japan.

Introduction: Venous thromboembolism prevention during the perioperative period requires comprehensive risk-level assessment. The aim of this study was to evaluate the incidence of deep vein thrombosis and to assess the cut-off levels of serum D-dimer as a screening strategy for deep vein thrombosis during the perioperative period.

Methods: A total of 205 patients (ovarian cancer: 68, endometrial cancer: 76, cervical cancer: 61) who underwent gynecological surgery, including retroperitoneal lymph node dissection, were enrolled. Read More

Exp Ther Med 2020 Apr 25;19(4):2923-2926. Epub 2020 Feb 25.

Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu 210009, P.R. China.

Ovarian vein thrombosis (OVT) is a rare medical complication that is most often diagnosed in the post-partum period. OVT can lead to conditions, including sepsis, inferior vena cava (IVC), pulmonary emboli and mortality. The current study outlines a case of a patient who experienced pain in the lower abdomen and waist without fever postpartum following caesarean section (CS). Read More

Br J Radiol 2020 May 1;93(1109):20200110. Epub 2020 Apr 1.

Department of Radiology, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, Japan.

Objective: Adnexal torsion is a rare gynecologic emergency caused by twisting of an adnexal mass. Twisted vascular pedicle is the most specific imaging finding for adnexal torsion, however, identification of twisted vascular pedicle can be challenging. The purpose of this study is to evaluate the feasibility of susceptibility-weighted MR sequence (SWS) for the diagnosis of adnexal torsion. Read More

Vasc Med 2020 Mar 18:1358863X20902842. Epub 2020 Mar 18.

Department of Internal Medicine, CHU Lille, Lille, France.

Internal jugular vein (IJV) thrombosis is mainly related to central venous catheter, malignancy, and ovarian hyperstimulation syndrome. We report a case of IJV thrombosis possibly related to IJV compression between the styloid process and the first cervical vertebra (C1) transverse process. To support this hypothesis, we perform radiological assessment of the IJV and examine its relationship with the styloid process and C1 transverse process in 34 controls. Read More

Cureus 2020 Feb 3;12(2):e6854. Epub 2020 Feb 3.

Family Medicine, Wellspan Good Samaritan Hospital, Lebanon, USA.

Ovarian Vein Thrombosis (OVT) is an extremely rare and uncommon thrombotic condition commonly attributed to the postpartum period. We report a case of a 30 yr old P2002 who presented with one day history of fever, chills, vomiting, abdominal and left flank pain. Patient had a preterm vaginal birth at 34 weeks gestation, four days prior to her presentation. Read More

Gynecol Obstet Fertil Senol 2020 Jun 12;48(6):506-513. Epub 2020 Mar 12.

Service de gynécologie-obstétrique et médecine de la reproduction, centre hospitalo-universitaire de Caen, bâtiment FEH, avenue de la Côte de Nacre, 14000 Caen, France.

Objective: Ovarian cancer is a risk factor for venous thromboembolism (VTE), which worsens overall survival. The main objective of our study was to calculate the incidence of VTE in our population. We analyzed VTE impact on diagnosis and management of ovarian cancer. Read More

Int J Surg Case Rep 2020 19;68:170-173. Epub 2020 Feb 19.

Department of Pathology, Pt. B D Sharma PGIMS, Rohtak, India. Electronic address:

Introduction: Respiratory distress is an uncommon clinical event after caesarean section and occurs due to pulmonary thromboembolism. Various causes of pulmonary thromboembolism are thrombophlebitis, ovarian venous thrombosis and mesenteric vein thrombosis.

Presentation Of Case: We report a case of 30 year old female who presented with respiratory distress after eight days of uneventful caesarian section. Read More

Chirurgia (Bucur) 2020 Jan-Feb;115(1):112-119

Postoperative ileus (POI) is a complex phenomenon with important morbidity and mortality, well known in many surgical fields. POI occurs commonly after abdominal and pelvic surgery, especially in cancer patients. We report the case of a 63-year-old patient without known risk factors for POI, who underwent total hysterectomy with bilateral adnexectomy for ovarian tumor with suspicion of malignancy, invalidated by the extemporaneous pathology examination. Read More

J Obstet Gynaecol Res 2020 May 8;46(5):765-773. Epub 2020 Mar 8.

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Aim: Postoperative pulmonary embolism can be a fatal surgical complication and is thought to occur secondary to asymptomatic venous thromboembolism (VTE) that exists preoperatively in some patients. The purpose of this study was to clarify the frequency and risk factors of pretreatment VTE in gynecological cancer patients.

Methods: This study investigated 2086 patients with gynecological cancer (cervix, n = 754; endometrium, n = 862; ovary, n = 470) who underwent initial treatment between 2004 and 2017. Read More

Intern Med J 2020 03;50(3):366-370

Department of Hematology, Instituto Nacional de Cancerología, Mexico City, Mexico.

Risk factors for venous thromboembolism in cancer vary between tumours. Leucocytosis, thrombocytosis, tumour histology and vascular compression may drive thrombosis in ovarian cancer. Thrombosis developed in 13. Read More

Front Vet Sci 2020 30;7:18. Epub 2020 Jan 30.

Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Swine models are commonly utilized in endovascular research for development of intravascular interventions and medical device development. As part of a pilot study for a venous vascular stent device, a 5-year-old female Yucatan mini-pig underwent bilateral external iliac vein stent placement under general anesthesia. To reduce thrombotic complications by reduction of thrombus formation on wires, sheaths, and catheters, the pig was heparinized with a total of 300 IU/kg of heparin, establishing an activated clotting time (ACT) of 436 s. Read More

Int Angiol 2020 Apr 13;39(2):112-117. Epub 2020 Feb 13.

Department of Vascular Surgery, University of Thessaly, Larissa, Greece -

Background: Our knowledge on the burden of symptomatic and asymptomatic venous thromboembolism (VTE) in patients with cancer undergoing chemotherapy is limited. The aim of our study was to prospectively investigate the frequency of symptomatic VTE and asymptomatic deep vein thrombosis of the lower limbs among cancer patients undergoing chemotherapy.

Methods: We studied 231 patients (164 men) with pancreatic (N. Read More

Int J Gynecol Cancer 2020 Apr 12;30(4):491-497. Epub 2020 Feb 12.

Gynecologic Oncology, Duke University Health System, Durham, North Carolina, USA

Objectives: Neoadjuvant chemotherapy may be considered for women with epithelial ovarian cancer who have poor performance status or a disease burden not amenable to primary cytoreductive surgery. Overlap exists between indications for neoadjuvant chemotherapy and known risk factors for venous thromboembolism, including impaired mobility, increasing age, and advanced malignancy. The objective of this study was to determine the rate of venous thromboembolism among women receiving neoadjuvant chemotherapy for epithelial ovarian cancer. Read More

Oncologist 2020 Jul 4;25(7):e1083-e1090. Epub 2020 Feb 4.

Center for Health Innovations and Outcomes Research, Feinstein Institute for Medical Research, Manhasset, New York, USA.

Background: Current risk assessment models (RAMs) for prediction of venous thromboembolism (VTE) risk in the outpatient cancer population have shown poor predictive value in many of the most common cancers. The Comparison of Methods for Thromboembolic Risk Assessment with Clinical Perceptions and AwareneSS in Real Life Patients-Cancer Associated Thrombosis (COMPASS-CAT) RAM was derived in this patient population and predicted patients at high risk for VTE even after initiation of chemotherapy. We sought to externally validate this RAM. Read More

Eur J Surg Oncol 2020 May 20;46(5):855-861. Epub 2020 Jan 20.

Anhui Medical University, Anhui Provincial Hospital, Hefei, 230001, China; Department of Obstetrics and Gynecology, The First Affiliated Hospital of University of Science & Technology of China, Anhui Provincial Hospital, Hefei, Anhui Province, 230001, China. Electronic address:

Objective: To assess the incidence and the risk factors of venous thromboembolism (VTE) in patients with epithelial ovarian carcinoma (EOC) during the perioperative period.

Methods: A retrospective analysis was conducted on the patients with epithelial ovarian cancer treated in our hospital, between January 2017 and July 2019, and a comprehensive review of the medical documentation was performed to collect relevant data. We then analyzed the related factors of the thrombosis in the EOC patients, using univariate and multivariate analysis to identify significant risk factors for VTE, and bootstrap resampling method was used to verify the multivariate analysis results. Read More

Int J Clin Oncol 2020 Mar 27;25(3):425-431. Epub 2020 Jan 27.

Department of Obstetrics and Gynecology, The Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.

Ovarian clear cell carcinoma (OCCC), with unique clinical and molecular characteristics compared with other histological types of epithelial ovarian cancer (EOC), behaves like a distinct entity and has a poorer prognosis than other EOC types, especially in advanced stages. In addition, OCCC comprises approximately 27% of all EOC cases in Japan, compared with 12% in Western countries. Historically, patients with OCCC have been eligible for chemotherapeutic and surgical trials of EOC. Read More

J Obstet Gynaecol Can 2020 Jan 23. Epub 2020 Jan 23.

Department of Obstetrics and Gynecology, Sultan Qaboos University Hospital, Muscat, Oman.

J Clin Ultrasound 2020 Jun 13;48(5):291-293. Epub 2020 Jan 13.

Department of Ultrasound, Shuyang People's Hospital, The Affiliated Shuyang Hospital of Xuzhou Medical University, Shuyang, Jiangsu, China.

Puerperal ovarian vein thrombophlebitis is a rare pathology. We present the case of a 23-year-old female who presented with fever and cough that occurred after vaginal delivery and persisted after several courses of antibiotics between the 2nd and 20th day postpartum. CT pulmonary angiography revealed right subsegmental pulmonary embolism. Read More

Blood 2020 01;135(5):326-334

Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, A. Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy.

Venous thrombosis rarely occurs at unusual sites such as cerebral, splanchnic, upper-extremity, renal, ovarian, or retinal veins. Clinical features, symptoms, and risk factors of rare thrombotic manifestations are heterogeneous and in large part differ from those typical of the commonest manifestations of venous thrombosis at the lower extremities. The therapeutic approach also varies widely according to the affected site, whether cerebral, abdominal, or extraabdominal. Read More

BMJ Case Rep 2019 Dec 15;12(12). Epub 2019 Dec 15.

Research Center, King Fahad Medical City, Riyadh, Saudi Arabia.

Mondor's disease (MD) is a rare disease characterised by thrombophlebitis of superficial veins in the body. We describe a case of a 28-year-old woman with a painful cord-like lesion of the right breast (3 cm) overlying the right upper quadrant. The patient was recently prescribed metformin and oral contraceptive pills for symptomatic polycystic ovarian syndrome. Read More

Hematology Am Soc Hematol Educ Program 2019 12;2019(1):148-151

Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Duke University, Durham, NC.

This is the obstetrician's view on 3 different clinical scenarios involving bleeding and thrombotic disorders. In the first scenario, an 18 year old with a history of heavy menstrual bleeding since menarche presents with abdominal pain and ultrasound findings suggestive of a hemorrhagic ovarian cyst. The association with an underlying bleeding disorder is recognized. Read More

Thromb Res 2020 Jan 13;185:49-54. Epub 2019 Nov 13.

Instituto Nacional de Câncer, INCA, Brazil. Electronic address:

Introduction: Venous thromboembolism (VTE) is a frequent clinical event in patients with gynecologic cancer. However, studies that exclusively address the incidence of VTE according the type of gynecologic cancer are poorly reported.

Objective: To analyze the incidence of VTE and the associated factors in women with different types of gynecologic cancer. Read More

SA J Radiol 2019 18;23(1):1683. Epub 2019 Apr 18.

Department of Radiology, Groote Schuur Hospital, University of Cape Town Medical School, Cape Town, South Africa.

Uterine leiomyomas are common benign neoplasms. While generally easily diagnosed, variations in size and type of degeneration can drastically alter the imaging findings and result in diagnostic uncertainty. We present the case of a 34-year-old female with a large, cystic, pelvi-abdominal mass that was discovered in advanced pregnancy and misdiagnosed as an ovarian tumour. Read More

Climacteric 2020 Apr 28;23(2):109-115. Epub 2019 Oct 28.

Gynaecological Endocrinology Unit, Paris Descartes University, Paris, France.

Estrogen has been known for a long time to be a trigger on auto-immunity and may influence the course of lupus. Women experiencing systemic lupus are at high risk for premature ovarian insufficiency if using cyclophosphamide, of osteoporosis, arterial ischemic diseases and venous thrombosis at young age. In about 30% of them, an antiphospholipid/anticoagulant antibody can occur which is associated with very high risk of thrombosis. Read More

Proc (Bayl Univ Med Cent) 2019 Oct 1;32(4):554-556. Epub 2019 Aug 1.

Department of Radiology, Trident Medical CenterCharlestonSouth Carolina.

Vena cava thrombosis arising from ovarian vein thrombosis in the postpartum period is a challenging clinical problem with limited treatment options. We describe the first reported use of veno-venous extracorporeal circulation and endovascular suction thrombectomy to treat inferior vena cava thrombosis in a postpartum patient. Read More

Geburtshilfe Frauenheilkd 2019 Oct 5;79(10):1100-1109. Epub 2019 Jun 5.

Klinik und Poliklinik für Geburtshilfe und Frauengesundheit, Universitätsmedizin Mainz, Mainz, Germany.

Venous thromboses and their consequences are among the main causes of death in patients with tumour diseases. The objective of this study is the analysis of risk factors and the evaluation of the applicability of two risk scores in a purely gynaecological oncology patient collective. The identification of patients at high risk for the occurrence of venous thromboses could enable the implementation of targeted medication-based thrombosis prophylaxis which has a significant benefit and, simultaneously, a low risk. Read More

Medicine (Baltimore) 2019 Sep;98(38):e16988

Department of Clinical Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Rationale: Peripherally inserted central catheters (PICC), normally located at the lower 1/3rd of the superior vena cava (SVC) and cavo-atrial junction, are commonly used in cancer patients. Persistent left superior vena cava (PLSVC) is a vascular anomaly, in patients with which seldom research was reported about PICC implanted. After obtaining written informed consent, we present a case where two successful insertions of PICC were performed in a 50-year-old female patient with PLSVC and right SVC. Read More

IEEE J Biomed Health Inform 2020 May 24;24(5):1500-1508. Epub 2019 Sep 24.

Thrombotic events are one of the leading causes of mortality and morbidity related to cancer, with ovarian cancer having one of the highest incidence rates. The need to prevent these events through the prescription of adequate schemes of antithrombotic prophylaxis has motivated the development of models that aid the identification of patients at higher risk of thrombotic events with lethal consequences. However, antithrombotic prophylaxis increases the risk of bleeding and this risk depends on the class and intensity of the chosen antithrombotic prophylactic scheme, the clinical and personal condition of the patient and the disease characteristics. Read More

Ann Vasc Surg 2020 Jan 24;62:500.e1-500.e3. Epub 2019 Sep 24.

Department of Cardiovascular Surgery, Giresun Ada Hospital, Giresun, Turkey. Electronic address:

Internal jugular vein (IJV) thrombosis is a rare vascular event. The most common causes of internal jugular vein thrombosis are prolonged central venous catheterization, infection, malignancy and ovarian hyperstimulation syndrome. We have presented here a case of an 82-year-old male with chronic kidney disease who presented with left neck swelling and pain who was found to have a thrombus in the left IJV. Read More

Am J Ther 2019 Sep 11. Epub 2019 Sep 11.

Hematology and Oncology, Cleveland Clinic, Cleveland, OH.

Gynecol Oncol Rep 2019 Aug 26;29:85-88. Epub 2019 Jul 26.

Department of Suergery, Division of Vascular Surgery, Mayo Clinic, Florida, USA.

•Superior mesenteric vein thrombosis (SMVT) is rare but seen in patients with hypercoagulable states.•Prevention of mortality in patients with SMVT requires immediate diagnosis and complex management.•A hierarchical approach to treatment progresses to more aggressive treatment as needed. Read More

Am J Med 2020 02 8;133(2):198-199. Epub 2019 Aug 8.

Division of Hospital Medicine, Department of Medicine, Case Western Reserve University MetroHealth Medical Center, Cleveland, Ohio.

Thromb Res 2019 Sep 2;181:112-119. Epub 2019 Aug 2.

Department of Surgical Gastroenterology, Aalborg University Hospital, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Clinical Cancer Research Center, Aalborg University Hospital, Denmark.

Objective: To determine the incidence of symptomatic and incidental venous thromboembolism (VTE) at time of diagnosis and throughout the first year, in patients with suspected epithelial ovarian cancer (EOC).

Methods: Patients were recruited consecutively in the gynecological outpatient clinic at Aalborg University Hospital, Denmark from December 2014 to May 2017. All patients underwent a whole leg compression ultrasound scan (CUS), Computed Tomography (CT) of the thorax in arterial phase at time of inclusion, to be able to diagnose deep vein thrombosis (DVT) and pulmonary embolism (PE), respectively. Read More

Surgery 2019 12 2;166(6):1076-1083. Epub 2019 Jul 2.

Division of Vascular and Endovascular Surgery, Hospital do Servidor Público Estadual, São Paulo, Brazil.

Background: In this article, we report the outcomes of patients with deep venous thrombosis in the lower limbs treated with the oral anticoagulant rivaroxaban or warfarin, focusing on the recanalization rate (measured with duplex ultrasound) and the incidence of postthrombotic syndrome.

Methods: This was a prospective, consecutive, randomized, blind cohort study of patients admitted with deep venous thrombosis to the Division of Vascular and Endovascular Surgery, Hospital do Servidor Público Estadual, São Paulo, Brazil, between March 2016 and July 2018. The patients were randomized into 2 groups and treated with oral anticoagulation for 6 months: either rivaroxaban (group 1) or warfarin (group 2). Read More

BMJ Case Rep 2019 Jun 21;12(6). Epub 2019 Jun 21.

Centro Hospitalar Barreiro Montijo EPE, Barreiro, Portugal.

A 34-year-old multipara presented 72 hours postpartum with acute right-sided abdominal pain. The investigation revealed mild leucocytosis with positive D-dimer and elevated C reactive protein. Abdominal ultrasound and abdominopelvic CT demonstrated an enlarged right ovarian vein with endoluminal thrombus, representing postpartum ovarian vein thrombosis. Read More

Int J Surg Case Rep 2019 3;60:63-65. Epub 2019 May 3.

Imam Abdulrahman bin Faisal University, Department of General Surgery, King Fahad University Hospital, Saudi Arabia.

Introduction: Abdominal pain is a common clinical challenge presenting to the emergency department. The challenge lies in the wide differentials particularly in females due to the addition of potential gynecological conditions. Ovarian vein thrombosis (OVT) is one of the uncommon differentials requiring rapid recognition & treatment to avoid serious complications or even death. Read More

Obstet Gynecol Sci 2019 May 10;62(3):190-193. Epub 2019 Apr 10.

Department of Obstetrics and Gynecology, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.

Ovarian vein thrombosis (OVT) is a rare disease with complications that can be life-threatening. An ovarian vein thrombus in a gestational trophoblastic neoplasia (GTN) is an extremely rare condition that has not been previously reported in the literature. We report the case of a 23-year-old woman who presented with symptoms of amenorrhea for 15 weeks and 6 days along with intermittent lower abdominal pain. Read More

BJR Case Rep 2019 Feb 5;5(1):20180025. Epub 2018 Oct 5.

Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK.

Heparin-induced thrombocytopaenia (HIT) is a life and limb-threatening acquired autoimmune complication of heparin-based treatment, characterised by thrombocytopaenia and thrombosis. We present a case of a 77-year-old female with concomitant metastatic ovarian and breast cancer who presented to our institution with worsening shortness of breath. She had been diagnosed with acute pulmonary embolism 1 month earlier that was treated with therapeutic low molecular weight heparin (LMWH). Read More

Int J Clin Oncol 2019 Oct 9;24(10):1273-1283. Epub 2019 May 9.

Department of Obstetrics and Gynecology, National Defense Medical College Hospital, Tokorozawa, 359-8513, Saitama, Japan.

Background: This study aimed to examine the clinical significance and risk factors of thromboembolic events (TEEs) in patients with ovarian carcinoma.

Methods: Patients with ovarian carcinoma treated at our hospital between 2000 and 2017 were identified. The risk factors of TEEs, including venous TEEs and arterial TEEs, and the association between TEEs and prognosis were investigated. Read More

Thromb Haemost 2019 Jul 5;119(7):1058-1071. Epub 2019 May 5.

Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan.

Interaction between the transcription factors, hypoxia-inducible factor (HIF1α and HIF2α) and Sp1, mediates hypoxia-driven expression of gene encoding coagulation factor VII (fVII) in ovarian clear cell carcinoma (CCC) cells. This mechanism is synergistically enhanced in response to serum starvation, a condition possibly associated with tumor hypoxia. This transcriptional response potentially results in venous thromboembolism, a common complication in cancer patients by producing procoagulant extracellular vesicles (EVs). Read More

J Thromb Haemost 2019 08 4;17(8):1297-1304. Epub 2019 Jun 4.

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.

Background: The risk of venous thromboembolism (VTE) in young women can predominantly be attributed to exogenous hormone use. The influence of (abnormalities in) endogenous sex hormones, as in polycystic ovary syndrome (PCOS) or primary ovarian insufficiency (POI), on VTE risk is uncertain.

Objectives: Th assess the association between endogenous sex hormone levels and VTE risk. Read More

Eur J Obstet Gynecol Reprod Biol 2019 Jun 11;237:57-63. Epub 2019 Mar 11.

The French Public Health Agency, Non-Communicable Disease and Trauma Division, Saint-Maurice, France.

Objectives: To determine whether the risk of thromboembolic complications is higher in women following unsuccessful fertility treatment (FT) and in pregnant women following successful FT, and whether the risk differs according to FT type.

Study Design: This is an observational prospective cohort study. All French women aged 18-45 years who received FT between 2013 and 2015 were selected from the French health insurance claim database which registers healthcare consumption for the entire French population. Read More