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Eur J Obstet Gynecol Reprod Biol 2019 Mar 11;237:57-63. Epub 2019 Mar 11.

The French Public Health Agency, Non-Communicable Disease and Trauma Division, Saint-Maurice, France.

Objectives: To determine whether the risk of thromboembolic complications is higher in women following unsuccessful fertility treatment (FT) and in pregnant women following successful FT, and whether the risk differs according to FT type.

Study Design: This is an observational prospective cohort study. All French women aged 18-45 years who received FT between 2013 and 2015 were selected from the French health insurance claim database which registers healthcare consumption for the entire French population. Read More

Phlebology 2019 Apr 3:268355519840846. Epub 2019 Apr 3.

1 Center for Vein Restoration, Greenbelt, MD, USA.

Introduction: Women with pelvic venous insufficiency often present with lower extremity symptoms and manifestations of chronic venous disorders. The purpose of this investigation was to determine the incidence of lower extremity chronic venous disorders and the types and distribution of lower extremity veins involved in patients with a known diagnosis of pelvic venous insufficiency.

Methods: Between January 2012 and December 2015, we retrospectively reviewed the charts of 227 women with pelvic venous insufficiency as well as their lower extremity venous duplex investigations. Read More

J Community Hosp Intern Med Perspect 2019 11;9(1):40-44. Epub 2019 Feb 11.

Florida Lung Asthma and Sleep Specialists, Florida Hospital, FL, USA.

A 43-year-old female presented with flank pain of two days duration. She had been admitted previously for bilateral lower extremity edema which had not improved with diuresis. Abdominal Imaging showed left ovarian vein thrombosis and left renal vein thrombosis extending into the IVC. Read More

J Stroke Cerebrovasc Dis 2019 May 14;28(5):e39-e43. Epub 2019 Feb 14.

Department of Neurosurgery, Kanazawa Medical Center, Kanazawa, Japan.

Background: Cerebral venous thrombosis is rare and an uncommon cause of stroke and has diverse etiologies and varied clinical presentations. Here, we report 2 cases of deep cerebral venous thrombosis.

Case Description: A 64-year-old woman presented with cerebral venous thrombosis due to a hypercoagulable state associated with ovarian tumor. Read More

J Vasc Surg Cases Innov Tech 2018 Dec 10;4(4):324-326. Epub 2018 Dec 10.

Department of Intervention, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Misplacement of an inferior vena cava (IVC) filter in a gonadal vein is a rare complication of IVC filter placement. We report a case of a filter misplaced in the ovarian vein of a pregnant woman with agenesis of the infrarenal IVC and bilateral lower extremity deep venous thrombosis. The filter was removed by a loop-snare technique through an internal jugular vein. Read More

Am J Obstet Gynecol 2019 Feb 8. Epub 2019 Feb 8.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Columbia University Medical Center, New York, NY.

Background: Ovarian hyperstimulation syndrome is a potentially life-threatening clinical condition.

Objective: The objective of this study was to evaluate risk factors for life-threatening complications for patients with severe ovarian hyperstimulation syndrome in a United States nationwide sample.

Materials And Methods: Ovarian hyperstimulation syndrome admissions from 2002 to 2011 from the Nationwide Inpatient Sample were included in this study. Read More

Clin Drug Investig 2019 Apr;39(4):395-400

Department of Obstetrics and Gynecology, Toho University Faculty of Medicine, 6-11-1 Omorinishi, Ota-ku, Tokyo, 143-8541, Japan.

Background And Objective: Administration of bevacizumab to ovarian cancer patients with distal deep vein thrombosis (DVT) is problematic because of lack of evidence about the likely outcomes. We conducted a preliminary study in ovarian cancer patients with DVT who received bevacizumab combined with a direct oral anticoagulant (DOAC).

Methods: We retrospectively investigated patients with advanced or recurrent epithelial ovarian cancer and distal DVT diagnosed by ultrasonography who underwent chemotherapy containing bevacizumab (15 mg/kg every 3 weeks) combined with DOAC therapy. Read More

Medicine (Baltimore) 2019 Jan;98(3):e14118

Heart Center, Cheng-Hsin General Hospital, Taipei.

Rationale: Pulmonary embolism is a potentially devastating medical condition. Although deep-vein thrombosis is the most common etiology, a nonthrombotic pulmonary embolism is not uncommon.

Patient Concerns: A 45-year-old woman was admitted to our hospital for progressive effort dyspnea for 3 weeks. Read More

Gynecol Oncol 2019 04 8;153(1):63-67. Epub 2019 Jan 8.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America; Dana-Farber Cancer Institute, Boston, MA, United States of America.

Objectives: To determine whether perioperative red blood cell transfusion (PRBCT) affects infection, thrombosis, or survival rates in epithelial ovarian cancer (EOC) patients undergoing neoadjuvant chemotherapy (NACT) and interval debulking surgery (IDS).

Methods: Demographics, operative characteristics, and outcome data were abstracted from records of stage IIIC-IV EOC patients managed with NACT-IDS from 01/2010-07/2015. Associations of PRBCT with morbidity and oncologic outcomes were evaluated. Read More

Emerg Radiol 2019 Apr 10;26(2):205-219. Epub 2019 Jan 10.

Department of Radiology, Henry Ford Hospital, Detroit, MI, USA.

Over the past 40 years since the first in vitro fertilization was performed, both the role of assisted reproductive technology (ART) in establishing viable pregnancy as well as the available treatment options have expanded enormously. Annually in the USA, nearly 2% of pregnancies now employ some form of ART assistance, with in vitro fertilization (IVF) being the most commonly utilized methodology. Both maternal and fetal risks are elevated in ART pregnancies, the latter including adverse outcome due to both increased gestational number as well as advanced maternal age. Read More

J Cardiol Cases 2018 Dec 5;18(6):207-209. Epub 2018 Sep 5.

Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

Deep vein thrombosis occasionally causes paradoxical embolism in patients with a patent foramen ovale (PFO). We report the case of a 42-year-old female who was hospitalized for stroke. Detailed investigations revealed the existence of a PFO, pulmonary embolism, and ovarian vein thrombosis extending to inferior vena cava. Read More

Menopause 2018 Dec 17. Epub 2018 Dec 17.

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Objective: To examine the associations between vaginal estrogen use and multiple health outcomes including cardiovascular disease (total myocardial infarction, stroke, and pulmonary embolism/deep vein thrombosis), cancer (total invasive, breast, endometrial, ovarian, and colorectal cancer), and hip fracture.

Methods: We included postmenopausal women from the Nurses' Health Study (1982-2012) who were not current users of systemic hormone therapy at the start of the study or during follow-up. Vaginal estrogen use was self-reported on the biennial questionnaires. Read More

Am J Cardiol 2019 Feb 24;123(4):679-683. Epub 2018 Nov 24.

Division of Cardiovascular Medicine, White River Junction VA Medical Center, White River Junction, Vermont; Department of Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. Electronic address:

Patients with cancer are at increased risk for venous thromboembolism (VTE). However, the relationship of cancer type to the risk of arterial thrombosis in patients with high VTE risk has not been described. The goal of this study is to determine the rate of arterial thrombosis in patients with different types of solid tumors stratified by VTE risk. Read More

Gynecol Oncol 2019 02 27;152(2):293-297. Epub 2018 Nov 27.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, USA. Electronic address:

Objective: Returning home after surgery is a desirable patient-centered outcome associated with decreased costs compared to non-home discharge. Our objective was to develop a preoperative risk-scoring model predicting non-home discharge after surgery for gynecologic malignancy.

Methods: Women who underwent surgery involving hysterectomy for gynecologic malignancy from 2013 to 2015 were identified from the Michigan Surgical Quality Collaborative database. Read More

Ugeskr Laeger 2018 Oct;180(44)

In this case report a 38-year-old woman presented with lower abdominal pain three weeks postpartum. She had been delivered by caesarean section after twin pregnancy and was given low-molecular heparin prophylaxis to be taken six weeks post caesarean. The initial clinical examination was normal. Read More

BMJ 2018 Sep 26;362:k3609. Epub 2018 Sep 26.

Academic Primary Care, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.

Objectives: To investigate the association between contemporary combined hormonal contraceptives (including progestogen types in combined preparations and all progestogen-only products) and overall and specific types of ovarian cancer.

Design: Prospective, nationwide cohort study.

Setting: Denmark, 1995-2014. Read More

Gynecol Minim Invasive Ther 2017 Oct-Dec;6(4):205-206. Epub 2017 Jun 26.

Japanese Red Cross Kyoto Daini Hospital, Department of Obstetrics and Gynecology, Japan.

Ovarian vein thrombosis in non-pregnant patient is a rare clinical entity. Among 170 patients who underwent total laparoscopic hysterectomy (TLH) in our hospital from December 2011 to December 2015, we have one case of ovarian vein thrombosis (0.0059%). Read More

Lymphology 2018 ;51(2):79-84

Department of Plastic and Reconstructive Surgery, Yokohama Municipal Citizen's Hospital, Yokohama, Japan.

We encountered a case in which we used a pedicled deep inferior epigastric perforator(DIEP) flap to repair a lymphatic leak. This case shows that such repairs can lead to the reconstruction of the lymphatic tract and prevent lymphatic leak recurrences. The present report describes a 45-year-old woman with ovarian cancer who underwent hysterectomy, bilateral salpingo-oophorectomy, pelvic lymphadenectomy, para-aortic lymphadenectomy, and omentectomy. Read More

J Hum Reprod Sci 2018 Apr-Jun;11(2):193-197

Department of Reproductive Medicine, Cloudnine Hospitals, Bengaluru, Karnataka, India.

We report a patient with a history of venous thrombosis following oral contraceptive pills who was planned for fertilization (IVF)-intracytoplasmic sperm injection for male factor infertility. This article discusses the mechanisms for predisposition to thrombosis during assisted reproduction in patients at high risk. Assessment of risk before commencement of treatment, use of mild stimulation, antagonist protocol, avoiding ovarian hyperstimulation, use of gonadotropin-releasing hormone agonist trigger and avoiding exposure to human chorionic gonadotropin, frozen embryo transfer in a natural cycle, single embryo transfer, avoiding multiple pregnancy, and use of prophylactic or therapeutic anticoagulation are the various risk-reduction strategies that must be adopted during IVF treatment to reduce the risk of thrombosis to that of natural conception. Read More

Medicine (Baltimore) 2018 Aug;97(31):e11754

Department of Obstetrics and Gynecology, Qilu Hospital.

The aim of this study was to assess the major risk factors for venous thromboembolism (VTE) in Chinese patients with ovarian cancer and to explore optimal methods of prophylaxis and treatment.A retrospective analysis of patients from Qilu Hospital of Shandong University was conducted from January 1, 2014, to January 1, 2017. We analyzed 388 patients who underwent surgery with a final diagnosis of ovarian cancer, of whom 35 developed VTE. Read More

Vasc Health Risk Manag 2018 16;14:153-155. Epub 2018 Jul 16.

Department of Surgery, Jordan University of Science and Technology, Irbid, Jordan,

Introduction: Spontaneous and isolated internal jugular vein (IJV) thrombosis is a rare entity, and atypical localization for venous thromboembolism usually occurs after an oropharyngeal infection, cancer, central venous catheter, and ovarian hyperstimulation syndrome. This report describes a case of spontaneous IJV thrombosis leading to neck pain and swelling as a primary manifestation of antiphospholipid (Hughes) syndrome.

Case Presentation: A 44-year-old male with no significant past medical history presented with a 1-week duration of right-sided painful neck swelling. Read More

Saudi Pharm J 2018 Jul 7;26(5):608-610. Epub 2018 Mar 7.

Chairman of the Obstetrics and Gynecology Department, Clemenceau Medical Center, Beirut, Lebanon.

Ovarian vein thrombosis (OVT) is a rare serious diagnosis especially if extending to inferior vein cava (IVC). We present a case of 36-year- old female who was diagnosed with right OVT reaching the inferior vein cava following a supra-cervical hysterectomy that was performed in the postpartum period due to excessive bleeding from uterine fibroids. Using the new generation anti-coagulant "rivaroxaban" for six months followed by maintenance regimen of aspirin and sulodexide, complete resolution of the clot was noticed without any adverse event while using this regimen. Read More

BMJ Case Rep 2018 Jun 23;2018. Epub 2018 Jun 23.

Department of Infectious Diseases and Tropical Medicine, Birmingham Heartlands Hospital, Heart of England NHS Hospital Trust, Birmingham, UK.

A 26-year-old woman presented with a 5-day history of fever after returning from Bali. She denied sexual contact abroad. On examination, there was suprapubic tenderness and a widespread maculopapular rash. Read More

Medicine (Baltimore) 2018 Jun;97(23):e11009

We aim to clarify the incidence of deep venous thrombosis (DVT) before treatment in women with ovarian cancer and identify risk factors for DVT.In this prospective study, 110 women underwent venous ultrasonography before cancer treatment and D-dimer levels were measured. We investigated factors predicting DVT by logistic regression. Read More

BMJ Open 2018 05 30;8(5):e018910. Epub 2018 May 30.

Department of Gastrointestinal Surgery, Osaka International Cancer Institute, Osaka, Japan.

Introduction: Patients with cancer are at higher risk of venous thromboembolism (VTE) than the general population as the malignancy itself and treatment modalities, including medication and surgery, contribute to the risk of developing VTE. Furthermore, patients with cancer developing VTE have a worse prognosis than those without cancer. There are no multicentre prospective data on the occurrence and treatment of VTE in patients with cancer in Japan, and data on the outcomes, complications and incidence of VTE in these patients have not been reported. Read More

Cureus 2018 Mar 19;10(3):e2343. Epub 2018 Mar 19.

Neurosurgery, Seattle Science Foundation.

A fenestration in the left ovarian vein was found in a fresh-frozen female cadaver. The opening did not have any vessels or additional anatomical structures passing through it. The ovarian vein is also referred to as the female gonadal vein. Read More

J Nepal Health Res Counc 2018 Mar 13;16(1):102-104. Epub 2018 Mar 13.

Department of Obstetrics and Gynaecology, Maharajgunj Medical Campus, Maharajgunj,Kathmandu, Nepal.

Ovarian vein thrombosis is one of the rare causes for acute abdomen. Occult presentation of this disease may lead to diagnostic dilemma. A sixteen years female who was operated as a case of ectopic pregnancy was finally diagnosed as having ovarian vein thrombosis. Read More

Cureus 2018 Feb 1;10(2):e2134. Epub 2018 Feb 1.

Department of Hematology and Oncology, Fairview Hospital, Cleveland Clinic, USA.

Ovarian vein thrombosis (OVT) is an rare condition, which can present in the postpartum period. We present a case of a 35-year-old female who presented with right lower quadrant pain and fever. Her computed tomography (CT) abdomen revealed a dilated right ovarian vein with soft tissue attenuation material in its lumen that extended into the inferior vena cava, along with fat stranding of the surrounding soft tissues signifying thrombophlebitis. Read More

Eur J Obstet Gynecol Reprod Biol 2018 May 19;224:117-124. Epub 2018 Mar 19.

Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD, 21287, United States. Electronic address:

Background: The majority of serious thromboembolic events occurring in assisted reproductive technologies (ART) are in women with ovarian hyperstimulation syndrome (OHSS).

Objectives: The purpose of this study was to present a thorough review and cost analysis regarding the use of venous thromboembolism (VTE) prophylaxis in OHSS to inform clinical management.

Data Sources: Databases used were Pubmed and Embase, in addition to checking reference lists of retrieved articles (inception to November 2017). Read More

BMJ Case Rep 2018 Mar 27;2018. Epub 2018 Mar 27.

Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

A 39-year-old woman was being treated for depression in our clinic. She subsequently developed a fever and was diagnosed with pancytopenia and moderate splenomegaly. Laboratory and bone marrow results, including markedly increased serum ferritin levels, suggested haemophagocytic lymphohistiocytosis. Read More

Obstet Gynecol 2018 Apr;131(4):740-741

UT Southwestern Medical Center, Dallas, Texas.

Hamostaseologie 2018 02 26;38(1):9-10. Epub 2018 Feb 26.

J Assist Reprod Genet 2018 Jul 13;35(7):1201-1207. Epub 2018 Mar 13.

Pelex, 931 Douglass Drive, McLean, VA, 22101, USA.

Purpose: To describe controlled ovarian stimulation (COS) in a population of women with GATA2 deficiency, a genetic bone marrow failure syndrome, prior to allogeneic hematopoietic stem cell transplant METHODS: This is a retrospective case series of nine women with GATA2 deficiency who underwent oocyte preservation at a research institution. Main outcomes measured include baseline fertility characteristics ((antimullerian hormone (AMH) and day 3 follicle-stimulating hormone (FSH) and estradiol (E2)) and total doses of FSH and human menopausal gonadotropins (HMG), E2 on day of trigger, and total number of metaphase II oocytes retrieved.

Results: The mean age was 24 years [16-32], mean AMH was 5. Read More

Vascul Pharmacol 2018 07 3;106:54-66. Epub 2018 Mar 3.

Departments of Pharmacology, University of Zagreb, Zagreb, Croatia.

Rat inferior caval vein (ICV) ligation (up to the right ovarian vein (ROV)) commonly represents a recapitulation of Virchow: with ligation leading to vessel injury, stasis, thrombosis and hemodynamic changes. We revealed that BPC 157's therapy collectively attenuated or counteracted all these events and the full syndrome.

Methods: We applied BPC 157 (10 μg, 10 ng/kg) as an early regimen or as a delayed therapy. Read More

Acta Clin Croat 2017 Sep;56(3):566-570

School of Medicine, Josip Juraj Strossmayer University, Osijek, Croatia.

Venous thromboembolism is a frequent complication of gynecologic cancer, and may be the first symptom of occult malignant disease. Although anticoagulation therapy remains the standard of care in patients presenting with acute venous thromboembolism, inferior vena cava filters are an important alternative when anticoagulants are contraindicated or ineffective. We report a case of a 69-year-old woman who presented with left leg swelling secondary to deep venous thrombosis before the diagnosis of ovarian cancer. Read More

JA Clin Rep 2018 5;4(1). Epub 2018 Jan 5.

Department of Cardiology, Osaka City Juso Hospital, 2-12-27, Nonaka-kita, Yodogawa-ku, Osaka, 532-0034 Japan.

Background: Ovarian vein thrombosis is a rare complication of pregnancy. The representative complaints of patients with ovarian vein thrombosis are abdominal pain and fever. In some cases, however, fatal pulmonary embolism may develop. Read More

Am J Case Rep 2017 Dec 15;18:1334-1342. Epub 2017 Dec 15.

Section of Vascular Surgery, University of Michigan Health System, Ann Arbor, MI, USA.

BACKGROUND Celiacomesenteric trunk (CMT) is a very rare anatomic finding in which the celiac artery and the superior mesenteric artery (SMA) originate from the abdominal aorta through a common trunk. Clinical associations with CMT include arterial aneurysm, thrombosis, and celiac artery compression. However, an association between CMT and abdominal venous congestion caused by left renal vein compression, or 'nutcracker phenomenon,' has not been previously reported. Read More

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):168-171

Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada; and.

Case Presentation: A 26-year-old woman experienced persistent fever (39.5°C), chills, and right-lower-quadrant tenderness 3 days after caesarean delivery. A computed tomography (CT) scan of the abdomen and pelvis with contrast revealed enlargement of her right ovarian vein with an associated intraluminal filling defect. Read More

Mayo Clin Proc 2018 01 6;93(1):40-47. Epub 2017 Dec 6.

Division of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. Electronic address:

Objectives: To assess the outcome of direct oral anticoagulants (DOACs), specifically Xa inhibitors: rivaroxaban and apixaban, for the treatment of venous thromboembolism (VTE) of atypical location (VTE-AL), portal, mesenteric, hepatic, splenic, gonadal, renal, and cerebral veins, prospectively collected data of Mayo Thrombophilia Clinic Registry were used.

Methods: Patients with acute VTE-AL treated with DOACs, enrolled between March 1, 2013, and February 1, 2017, were compared with patients with VTE of typical location (VTE-TL: deep vein thrombosis of extremities and/or pulmonary embolism) receiving DOACs and with patients with VTE-AL treated with enoxaparin.

Results: Out of 623 patients with acute VTE receiving the study drug within 14 days of diagnosis, there were 63 with VTE-AL: 36 on DOAC, 23 on enoxaparin, and 4 on warfarin; 352 received DOAC for VTE-TL. Read More

J Thromb Thrombolysis 2018 Feb;45(2):234-239

Atherosclerosis and Thrombosis Unit, I.R.C.C.S. "Casa Sollievo della Sofferenza", Poliambulatorio Giovanni Paolo II, Viale Padre Pio, 71013, San Giovanni Rotondo (Foggia), Italy.

Pregnancies after assisted reproductive technologies (ART) have been associated with an increased risk of venous thromboembolism (VTE). On the contrary, the magnitude of this risk in unsuccessful ART cycles (not resulting in a clinical pregnancy) has not yet been clearly defined. In this study, we evaluated the incidence of VTE in unsuccessful cycles and compared it with that recorded in successful cycles in the same study population. Read More

Emerg Radiol 2018 Apr 15;25(2):147-152. Epub 2017 Nov 15.

Department of Radiology, Thomas Jefferson University Hospitals, 132 South 10th Street, Philadelphia, PA, 19107, USA.

Purpose: The vast amount of information found on the internet, combined with its accessibility, makes it a widely utilized resource for Americans to find information pertaining to medical information. The field of radiology is no exception. In this paper, we assess the readability level of websites pertaining specifically to emergency radiology. Read More

Rev Med Suisse 2017 Oct;13(580):1821-1825

Unité de médecine de la reproduction et d'endocrinologie gynécologique, HUG et Faculté de médecine, 1211 Genève 14.

Venous thromboembolism is frequently associated with hormonal factors in women. A thorough medical history taking of vascular risks and an individual evaluation of the risk-benefit ratio should precede any prescription of hormonal therapies. In contrary to progestin-only-pills, estroprogestative contraceptives increase 3-6 times the risk of venous thrombosis. Read More

Aust Fam Physician 2017 Oct;46(10):728-732

Background: Despite the general consensus that long-acting reversible contraceptives (LARCs) are the most appropriate choice of contraception for most women, there are special circumstances when the contraceptive and non-contraceptive needs of the patient are met by oral methods.

Objective: By using case histories, we seek to demonstrate the medical and practical complexities in managing contraceptive needs that may result in oral contraception being the most appropriate choice. The cases also illustrate the resources available to enable evidence-based management. Read More

Clin Transplant 2017 Dec 28;31(12). Epub 2017 Nov 28.

Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel.

We performed autologous uterus transplantation using the living-sheep donor model for team preparation before human uterine transplantation. Five sequential operations (in 3 ewes) were prospectively conducted. Surgical technique included uterus retrieval, graft preparation, and uterus transplantation. Read More

Int J Surg Case Rep 2017 4;41:1-4. Epub 2017 Oct 4.

1st OB.GYN Department, School of Medicine, National and Kapodistrian University of Athens, Alexandra Hospital, Lourou and Vasilissis Sofias Ave., 11528 Athens, Greece. Electronic address:

Introduction: Ovarian vein thrombosis is a rare but potentially serious complication after surgical and gynecologic procedures such as oophorectomy and hysterectomy. The association of this event with laparoscopic hysterectomy in particular, is very rare. Only two cases have been described so far. Read More

Obstet Gynecol 2017 11;130(5):1127-1135

Gonda Vascular Center, Mayo Clinic, Rochester, Minnesota; and Duke Medical Center, Durham, North Carolina.

Objective: To identify the risk of venous thromboembolism recurrence, major bleeding, and mortality in patients with ovarian vein thrombosis so as to better define optimal treatment strategies.

Methods: Patients with ovarian vein thrombosis (1990-2015) and age- and gender-matched patients with contemporary leg deep vein thrombosis (DVT) were assessed for differences in etiology, venous thromboembolism recurrence, and survival in a case-control study.

Results: Over the timeframe of this study, only 219 ovarian vein thrombosis cases were identified compared with 13,417 leg DVTs. Read More

Int J Gynecol Cancer 2017 11;27(9):1970-1978

Academic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London, United Kingdom.

Objective: Venous thromboembolism (VTE) is a recognized complication of gynecological malignancy and represents a leading cause of morbidity and mortality in these patients. The review aimed to discuss the incidence, risk factors, and clinical presentation of VTE before examining the literature on the diagnosis, prevention, and management in the context of uterine, cervical, ovarian, and vulval cancers.

Methods/materials: A literature search was performed using Ovid Medline and Embase with the following words: "gynecological malignancy," "pelvic tumor," "venous thromboembolism," "deep vein thrombosis" and "pulmonary embolism. Read More

Malays J Pathol 2017 08;39(2):123-133

Universiti Sains Malaysia, School of Medical Sciences, Human Genome Centre, Kelantan, Malaysia.

Background: Antiphospholipid syndrome (APS) is an autoimmune disorder characterised by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies (aPLs) based on the Sydney criteria. We aimed to explore the clinico-laboratory features and treatment strategies of APS patients retrospectively.

Methodology: The medical records of APS patients registered under Hospital Universiti Sains Malaysia (Kelantan state) between 2000 and 2015 were reviewed. Read More

Blood 2017 09 14;130(13):1499-1506. Epub 2017 Aug 14.

Division of Hematology and Oncology, Department of Medicine, Thrombosis and Hemostasis Program, University of North Carolina at Chapel Hill, Chapel Hill, NC; and.

Cancer patients have an increased risk of venous thromboembolism (VTE). In this review, we summarize common and cancer type-specific pathways of VTE in cancer patients. Increased levels of leukocytes, platelets, and tissue factor-positive (TF) microvesicles (MVs) are all potential factors that alone or in combination increase cancer-associated thrombosis. Read More

Arch Gynecol Obstet 2017 Oct 12;296(4):691-700. Epub 2017 Aug 12.

Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Carmel Medical Center, Michal Street number 7, Haifa, Israel.

Most ovarian cancer patients are diagnosed in an advanced stage; and after the initial treatment experience disease recurrence, which eventually becomes palliative. Many questions arise in this setting including how to address patients in the palliative setting, how to discuss end-of-life issues, and how to manage symptoms. In this review, we discuss the timing and setting of end-of-life discussion in the context of end-stage ovarian cancer. Read More