FMR1 and AKT/mTOR signalling pathways: potential functional interactions controlling folliculogenesis in human granulosa cells.
- Julia Rehnitz,
- Diego D Alcoba,
- Ilma S Brum,
- Katrin Hinderhofer,
- Berthe Youness,
- Thomas Strowitzki,
- Peter H Vogt
Reprod Biomed Online 2017 Aug 4. Epub 2017 Aug 4.
Reproduction Genetics Unit, Department of Gynecological Endocrinology and Fertility Disorders, University Women's Hospital, 69120 Heidelberg, Germany.
Granulosa cells (GCs) play a major role in folliculogenesis and are crucial for oocyte maturation and growth. In these cells, the mTOR/AKT signalling pathway regulates early folliculogenesis by maintaining the dormancy of primordial follicles, while FSH induces their further differentiation and maturation. Because changes in number of CGG triplets in FMR1 exon 1 (below or beyond normal values of 26-34 triplets) affect ovarian reserve and pre-mutations containing >54 CGG triplets represent a known risk factor for premature ovarian insufficiency/failure, we investigated in the human GC model (COV434) how FMR1/FMRP and mTOR/AKT are expressed and potentially interact during GC proliferation. Read More