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    3225 results match your criteria Ovarian Insufficiency

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    Characterization of FOXO1, 3 and 4 transcription factors in ovaries of fetal, prepubertal and adult rhesus macaques.
    Biol Reprod 2017 Apr 22. Epub 2017 Apr 22.
    Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, 97006, USA.
    The phosphoinositide 3-kinase/AKT signaling pathway negatively regulates follicle activation via the forkhead box O (FOXO) transcription factor in rodents. FOXO3 knockout mice exhibit global activation of primordial follicles leading to early depletion of ovarian follicles and subsequent infertility. Whether a similar mechanism for follicle activation exists in the primate ovary is unclear. Read More

    Age-independent anti-Müllerian hormone (AMH) standard deviation scores to estimate ovarian function.
    Eur J Obstet Gynecol Reprod Biol 2017 Apr 18;213:64-70. Epub 2017 Apr 18.
    Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry University, Hospital RWTH Aachen, 51072 Aachen, Germany.
    Objectivies: To determine single year age-specific anti-Müllerian hormone (AMH) standard deviation scores (SDS) for women associated to normal ovarian function and different ovarian disorders resulting in sub- or infertility.

    Design And Methods: Determination of particular year median and mean AMH values with standard deviations (SD), calculation of age-independent cut off SDS for the discrimination between normal ovarian function and ovarian disorders.

    Results: Single-year-specific median, mean, and SD values have been evaluated for the Beckman Access AMH immunoassay. Read More

    Committee Opinion No. 698: Hormone Therapy in Primary Ovarian Insufficiency.
    • Authors:
    Obstet Gynecol 2017 05;129(5):e134-e141
    Primary ovarian insufficiency describes a spectrum of declining ovarian function and reduced fecundity due to a premature decrease in initial follicle number, an increase in follicle destruction, or poor follicular response to gonadotropins. The sequelae of primary ovarian insufficiency include vasomotor symptoms, urogenital atrophy, osteoporosis and fracture, cardiovascular disease, and increased all-cause mortality. In women with primary ovarian insufficiency, systemic hormone therapy (HT) is an effective approach to treat the symptoms of hypoestrogenism and mitigate long-term health risks if there are no contraindications to treatment. Read More

    Committee Opinion No. 698 Summary: Hormone Therapy in Primary Ovarian Insufficiency.
    • Authors:
    Obstet Gynecol 2017 May;129(5):963-964
    Primary ovarian insufficiency describes a spectrum of declining ovarian function and reduced fecundity due to a premature decrease in initial follicle number, an increase in follicle destruction, or poor follicular response to gonadotropins. The sequelae of primary ovarian insufficiency include vasomotor symptoms, urogenital atrophy, osteoporosis and fracture, cardiovascular disease, and increased all-cause mortality. In women with primary ovarian insufficiency, systemic hormone therapy (HT) is an effective approach to treat the symptoms of hypoestrogenism and mitigate long-term health risks if there are no contraindications to treatment. Read More

    Hormone therapy for premature ovarian insufficiency patients with malignant hematologic diseases.
    Climacteric 2017 Apr 11:1-9. Epub 2017 Apr 11.
    d Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University Institute of Hematology, People's Hospital , Beijing , China.
    Objectives: The current usage of hormone therapy (HT) among perimenopausal women is low in China, especial in women with premature ovarian insufficiency (POI) with malignant hematologic diseases. This study investigated the efficacy and safety of HT in POI patients with malignant hematologic diseases who have received myeloablative chemotherapy and hemopoietic stem cell transplantation (HSCT).

    Methods: Patients who had POI after myeloablative chemotherapy and HSCT for malignant hematologic diseases were enrolled. Read More

    Whole-exome sequencing identifies a homozygous donor splice site mutation in STAG3 that causes primary ovarian insufficiency.
    Clin Genet 2017 Apr 10. Epub 2017 Apr 10.
    Institute of Reproduction and Stem Cell Engineering, Central South University, Changsha, Hunan, 410078, People's Republic of China.
    Primary ovarian insufficiency (POI) is the depletion or loss of normal ovarian function, which cause infertility in women before the age of 40 years. Two homozygous germline truncation mutations in STAG3 gene had been reported to causes POI in consanguineous families. Here, we aimed to identify the genetic cause of POI in two affected sisters manifested with primary amenorrhea and partial development of secondary sexual characters with normal range of height of a consanguineous Han Chinese family. Read More

    Determinants of percent mammographic density in women with premature ovarian insufficiency.
    Climacteric 2017 Apr 9:1-5. Epub 2017 Apr 9.
    a Department of Obstetrics and Gynecology, School of Medical Sciences , University of Campinas , São Paulo , Brazil.
    Objective: To evaluate the determinants of breast density in women with premature ovarian insufficiency (POI).

    Methods: In a cross-sectional study of 163 women with POI undergoing mammography, percent mammographic density (PMD) was evaluated by digitizing the image. PMD was correlated with age, age at menarche, age at POI, time since POI, body mass index (BMI), gestational history and hormone therapy (HT) use (duration, dose, regimen). Read More

    Oocyte stem cells: fact or fantasy?
    Reproduction 2017 Apr 7. Epub 2017 Apr 7.
    S Williams, Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford, United Kingdom of Great Britain and Northern Ireland
    For many decades, the dogma prevailed that female mammals had a finite pool of oocytes at birth and this was gradually exhausted during a lifetime of reproductive function. However, in 2004, a new era began in the field of female oogenesis. A study was published that appeared to detect oocyte-stem cells capable of generating new eggs within mouse ovaries. Read More

    Environmental pollutants, a possible etiology for premature ovarian insufficiency: a narrative review of animal and human data.
    Environ Health 2017 Apr 7;16(1):37. Epub 2017 Apr 7.
    Médecine de la Reproduction, CHU de Toulouse, Hôpital Paule de Viguier, 330 avenue de Grande Bretagne, F-31059, Toulouse Cedex, France.
    Background: Because only 25% of cases of premature ovarian insufficiency (POI) have a known etiology, the aim of this review was to summarize the associations and mechanisms of the impact of the environment on this pathology. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included ovary, follicle, oocyte, endocrine disruptor, environmental exposure, occupational exposure, environmental contaminant, pesticide, polyaromatic hydrocarbon, polychlorinated biphenyl PCB, phenol, bisphenol, flame retardant, phthalate, dioxin, phytoestrogen, tobacco, smoke, cigarette, cosmetic, xenobiotic. Read More

    Sensitivity and specificity of clinical findings for the diagnosis of pelvic congestion syndrome in women with chronic pelvic pain.
    Phlebology 2017 Jan 1:268355517702057. Epub 2017 Jan 1.
    2 Grupo de Investigación Salud Comfamiliar, Pereira, Colombia.
    Background Pelvic congestion syndrome is among the causes of pelvic pain. One of the diagnostic tools is pelvic venography using Beard's criteria, which are 91% sensitive and 80% specific for this syndrome. Objective To assess the diagnostic performance of the clinical findings in women diagnosed with pelvic congestion syndrome coming to a Level III institution. Read More

    Review of clinical indicators, including serum anti-Müllerian hormone levels, for identification of women who should consider egg freezing.
    Int J Gynaecol Obstet 2017 Apr 4. Epub 2017 Apr 4.
    Merrion Fertility Clinic, Dublin, Ireland.
    Objective: To identify women, on the basis of clinical history and serum anti-Müllerian hormone (AMH) levels, who are at risk of premature ovarian insufficiency and thereby guide appropriate early referral for egg freezing.

    Methods: In a retrospective study, data were reviewed from women attending two fertility clinics in Dublin, Ireland, between August 2011 and December 2012. Case histories of women aged 35 years or younger were assessed to identify risk factors for reduced ovarian reserve, including endometriosis, ovarian surgery, and family history of premature ovarian failure (POF). Read More

    Use of Hormone Replacement in Females with Endocrine Disorders.
    Horm Res Paediatr 2017 Apr 4;87(4):215-223. Epub 2017 Apr 4.
    Hormone replacement therapy (HRT) is necessary in adolescents with primary ovarian insufficiency (POI) in order to avoid estrogen deficiency. The goal of this minirewiew is to present the different types of estrogens (17β-estradiol, estradiol valerate, ethinyl estradiol, and combined equine estrogens) as well as the different types of progestins available. In order to choose among the different types of HRTs, the features of each regimen are being discussed as well as their risks and their respective benefits. Read More

    Premature Ovarian Insufficiency: Phenotypic Characterization within Different Etiologies.
    J Clin Endocrinol Metab 2017 Mar 28. Epub 2017 Mar 28.
    Center for Reproductive Medicine, Shandong University. National Research Center for Assisted Reproductive Technology and Reproductive Genetics, China. The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.
    Context: Premature ovarian insufficiency (POI) is highly heterogeneous, both in phenotype and etiology. They are not yet clearly stated and correlated.

    Objective: To characterize clinical presentations of a large, well-phenotyped cohort of women with POI, and correlate phenotypes with etiologies to draw a comprehensive clinical picture of POI. Read More

    Premature Ovarian Insufficiency in Childhood Cancer Survivors: A Report from the St. Jude Lifetime Cohort.
    J Clin Endocrinol Metab 2017 Mar 24. Epub 2017 Mar 24.
    Memorial Sloan Kettering Cancer Center, New York NY, USA-Department of Pediatrics.
    Context: Long-term follow-up data on premature ovarian insufficiency (POI) in childhood cancer survivors are limited.

    Context: To describe the prevalence of POI, its risk factors and associated long-term adverse health outcomes.

    Design: Cross-sectional. Read More

    Recent advances in the field of ovarian tissue cryopreservation and opportunities for research.
    J Assist Reprod Genet 2017 Apr 1. Epub 2017 Apr 1.
    Howard W. and Georgeanna Seegar Jones Division of Reproductive Sciences and Women's Health Research, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross Building (Room 624), Baltimore, MD, 21205, USA.
    Purpose: The purpose of this study was to summarize the latest advances and successes in the field of ovarian tissue cryopreservation while identifying gaps in current knowledge that suggest opportunities for future research.

    Methods: A systematic review was performed according to PRISMA guidelines for all relevant full-text articles in PubMed published in English that reviewed or studied historical or current advancements in ovarian tissue cryopreservation and auto-transplantation techniques.

    Results: Ovarian tissue auto-transplantation in post-pubertal women is capable of restoring fertility with over 80 live births currently reported with a corresponding pregnancy rate of 23 to 37%. Read More

    BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9.
    J Clin Endocrinol Metab 2017 Mar;102(3):1009-1019
    Department of Physiology, Monash University, Clayton, Victoria 3800, Australia.
    Context: Bone morphogenetic protein (BMP)15 is an oocyte-specific growth factor, which, together with growth differentiation factor (GDF) 9, regulates folliculogenesis and ovulation rate. Multiple mutations in BMP15 have been identified in women with primary ovarian insufficiency (POI), supporting a pathogenic role; however, the underlying biological mechanism of many of these mutants remains unresolved.

    Objectives: To determine how mutations associated with ovarian dysfunction alter the biological activity of human BMP15. Read More

    Polycystic ovarian syndrome and the risk of subsequent primary ovarian insufficiency: a nationwide population-based study.
    Menopause 2017 Mar 27. Epub 2017 Mar 27.
    1Institute of Information Science, Academia Sinica, Taipei, Taiwan 2Department of Physical Medicine and Rehabilitation, Mackay Memorial Hospital, Taipei, Taiwan 3Department of Mechanical Engineering, National Chiao-Tung University, Hsinchu, Taiwan 4Department of Obstetrics and Gynecology, Taipei Tzu-Chi Hospital, The Buddhist Tzu-Chi Medical Foundation, Taipei, Taiwan 5School of Medicine, Tzu-Chi University, Hualien, Taiwan.
    Objective: To evaluate the risk of subsequent primary ovarian insufficiency (POI) amongst patients with a history of polycystic ovarian syndrome (PCOS).

    Methods: This nationwide, population-based study is an inspection and review of data from the 1998 to 2012 Taiwan National Health Insurance Research Database. In a sample of 1,000,000 randomly sampled individuals, women with PCOS (exposure group; n = 7,049) and women without PCOS (contrast group; n = 70,490) were compared. Read More

    Galactose and its Metabolites Deteriorate Metaphase II Mouse Oocyte Quality and Subsequent Embryo Development by Disrupting the Spindle Structure.
    Sci Rep 2017 Mar 22;7(1):231. Epub 2017 Mar 22.
    Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
    Premature ovarian insufficiency (POI) is a frequent long-term complication of classic galactosemia. The majority of women with this disorder develop POI, however rare spontaneous pregnancies have been reported. Here, we evaluate the effect of D-galactose and its metabolites, galactitol and galactose 1-phosphate, on oocyte quality as well as embryo development to elucidate the mechanism through which these compounds mediate oocyte deterioration. Read More

    A potential functional association between mutant BMPR2 and primary ovarian insufficiency.
    Syst Biol Reprod Med 2017 Jun 17;63(3):145-149. Epub 2017 Mar 17.
    a Centro de Investigación en Genética y Genómica-CIGGUR, Grupo GENIUROS, Escuela de Medicina y Ciencias de la Salud , Universidad del Rosario , Bogotá , Colombia.
    Primary ovarian insufficiency (POI) affects ~1% of women in the general population. Despite numerous attempts at identifying POI genetic aetiology, coding mutations in only a few genes have been functionally related to POI pathogenesis. It has been suggested that mutant BMPR2 might contribute towards the phenotype. Read More

    Spontaneous Regression of Uterine Arteriovenous Malformations with Conservative Management.
    Case Rep Obstet Gynecol 2017 16;2017:6437670. Epub 2017 Feb 16.
    Department of Obstetrics and Gynecology, Graduate School of Medical Science, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan.
    Uterine arteriovenous malformation (AVM) can cause massive hemorrhage and is often treated with uterine artery embolization (UAE), which may lead to ovarian insufficiency. Thus, avoiding UAE should be considered, particularly in women undergoing fertility treatments. We present three women diagnosed with postmiscarriage AVM on color Doppler by transvaginal ultrasound imaging. Read More

    Learning and memory disabilities in IUGR babies: Functional and molecular analysis in a rat model.
    Brain Behav 2017 Mar 7;7(3):e00631. Epub 2017 Feb 7.
    Department of Pathology and Experimental Therapeutics School of Medicine University of Barcelona Barcelona Spain.
    Introduction: 1Intrauterine growth restriction (IUGR) is the failure of the fetus to achieve its inherent growth potential, and it has frequently been associated with neurodevelopmental problems in childhood. Neurological disorders are mostly associated with IUGR babies with an abnormally high cephalization index (CI) and a brain sparing effect. However, a similar correlation has never been demonstrated in an animal model. Read More

    Disorganization of the germ cell pool leads to primary ovarian insufficiency.
    Reproduction 2017 Jun 13;153(6):R205-R213. Epub 2017 Mar 13.
    Department of Advanced Reproductive MedicineSt. Marianna University School of Medicine, Kawasaki City, Kanagawa, Japan
    The mammalian ovary is an organ that controls female germ cell development, storing them and releasing mature oocytes for transporting to the oviduct. During the fetal stage, female germ cells change from a proliferative state to meiosis before forming follicles with the potential for the growth of surrounding somatic cells. Understanding of molecular and physiological bases of germ cell development in the fetal ovary contributed not only to the elucidation of genetic disorders in primary ovarian insufficiency (POI), but also to the advancement of novel treatments for patients with POI. Read More

    Genetics of Reproductive Aging from Gonadal Dysgenesis through Menopause.
    Semin Reprod Med 2017 Mar 9;35(2):147-159. Epub 2017 Mar 9.
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.
    Reproduction is essential for the survival of the species and is influenced by external factors such as smoking and exposure to chemotherapy as well as chronic disorders such as obesity and autoimmunity. Reproductive senescence, such as menopause, is also dependent on multiple intrinsic genetic factors. Reproductive aging is not isolated from an overall aging process, and several studies strongly support the link between the early age of menopause and mortality. Read More

    Brain-derived neurotrophic factor (BDNF) plasma concentration in patients diagnosed with premature ovarian insufficiency (POI).
    Gynecol Endocrinol 2017 Feb 28:1-5. Epub 2017 Feb 28.
    a Department of Gynecological Endocrinology , Poznan University of Medical Sciences , Poznan , Poland.
    Premature ovarian insufficiency (POI) is defined as a cessation of function of ovaries in women younger than 40 years old. Brain-derived neurotrophic factor (BDNF) is a protein critically involved in neuronal growth and metabolism. BDNF also has been shown to be important regulator of oocyte maturation. Read More

    Accuracy and safety verification of ovarian reserve assessment technique for ovarian tissue transplantation using optical coherence tomography in mice ovary.
    Sci Rep 2017 Mar 8;7:43550. Epub 2017 Mar 8.
    Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kawasaki, Japan.
    Except for histological study, there are currently no suitable techniques available for the detection and identification of primordial follicles in ovary of primary ovarian insufficiency patients who have undetectable AMH levels. Also, the ability to locate and quantify follicles on ovarian cortex strips, without fixation, is valuable for patients who could undergo subsequent successful ovarian tissue transplantation. Although optical coherence tomography (OCT) is a well-established high resolution imaging technique without fixation commonly applied in biomedicine, few reports are available on ovarian tissue imaging. Read More

    A general description for Chinese medicine in treating premature ovarian failure.
    Chin J Integr Med 2017 Feb 7;23(2):91-97. Epub 2017 Mar 7.
    Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Institutes of Biomedical Sciences (IBS), Fudan University Shanghai Medical College, Shanghai, 200032, China.
    Premature ovarian failure (POF) is a kind of gynecological disease that causes amenorrhea, infertility, menopause and urogenital symptoms. Currently hormone replacement therapy (HRT) is the most popular choice for women with POF to get rid of menopausal syndrome. However, as the popularization of Chinese herbs made Chinese medicine (CM) shine new lights, physicians are able to treat POF with both meno-herbs and integrated therapy. Read More

    Primary Ovarian Insufficiency: Current Concepts.
    South Med J 2017 Mar;110(3):147-153
    From the Department of Reproductive Biology, Department of Gynecology, Case Western Reserve University, Cleveland, Ohio, and Department of Obstetrics and Gynecology, Wake Forest University, Winston-Salem, North Carolina.
    A potential consequence of chemotherapy is the destruction of oocytes, resulting in primary ovarian insufficiency (POI) in young patients; this often results in secondary amenorrhea and necessitates hormone replacement therapy. Regardless of the etiology of POI, the chance of pregnancy is low in this patient population. Given the extent to which oocyte depletion or dysfunction is variable, there is the possibility of spontaneous ovulation on hormone replacement therapy and subsequent pregnancy, however. Read More

    Babies born from three young infertile sisters with premature ovarian insufficiency caused by inherited fragile X syndrome: An intergenerational report.
    Taiwan J Obstet Gynecol 2017 Feb;56(1):112-113
    Center for Reproductive Medicine and Sciences, Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

    [Hematopoietic stem cells transplant in patients with common variable immunodeficiency. Is a therapeutic option?]
    Rev Alerg Mex 2017 Jan-Mar;64(1):121-125
    Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Servicio de Alergia e Inmunología Clínica. Ciudad de México, México.
    Background: Patients with common variable immunodeficiency show higher incidence of sinopulmonary and gastrointestinal infections, as well as lymphoproliferative and autoimmune diseases. The treatment of choice is replacement therapy with human gamma-globulin. Hematopoietic stem cell transplantation is a non-conventional therapeutic modality. Read More

    Mutations in MSH5 in primary ovarian insufficiency.
    Hum Mol Genet 2017 Apr;26(8):1452-1457
    Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, P.R. China.
    Primary ovarian insufficiency (POI) is a genetically heterogeneous disorder that occurs in familial or sporadic fashion. Through whole exome sequencing in a Chinese pedigree with POI, we identified a novel homozygous missense mutation (ENST00000375755: c.1459G > T, p. Read More

    A Retrospective Study on the Onset of Menopause after Chemotherapy: Analysis of Data Extracted from the Jean Perrin Comprehensive Cancer Center Database Concerning 345 Young Breast Cancer Patients Diagnosed between 1994 and 2012.
    Oncology 2017 8;92(5):255-263. Epub 2017 Feb 8.
    ERTICA EA 4677, Université d'Auvergne, Clermont-Ferrand, France.
    Objective: Young breast cancer (BC) patients receiving chemotherapy are at risk of chemotherapy-induced menopause (CIM). We sought to define the incidence rate of premature menopause after chemotherapy and to retrospectively investigate factors related to the onset of menopause.

    Methods: We identified BC patients who had received chemotherapy at the Cancer Center (Centre Jean-Perrin). Read More

    The Glycosyltransferase ST6Gal-I Protects Tumor Cells against Serum Growth Factor Withdrawal by Enhancing Survival Signaling and Proliferative Potential.
    J Biol Chem 2017 Mar 30;292(11):4663-4673. Epub 2017 Jan 30.
    From the Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294
    A hallmark of cancer cells is the ability to survive and proliferate when challenged with stressors such as growth factor insufficiency. In this study, we report a novel glycosylation-dependent mechanism that protects tumor cells from serum growth factor withdrawal. Our results suggest that the β-galactoside α-2,6-sialyltransferase 1 (ST6Gal-I) sialyltransferase, which is up-regulated in numerous cancers, promotes the survival of serum-starved cells. Read More

    AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy.
    Proc Natl Acad Sci U S A 2017 Feb 30;114(9):E1688-E1697. Epub 2017 Jan 30.
    Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, MA 02114;
    The ovarian reserve represents the stock of quiescent primordial follicles in the ovary which is gradually depleted during a woman's reproductive lifespan, resulting in menopause. Müllerian inhibiting substance (MIS) (or anti-Müllerian hormone/AMH), which is produced by granulosa cells of growing follicles, has been proposed as a negative regulator of primordial follicle activation. Here we show that long-term parenteral administration of superphysiological doses of MIS, using either an adeno-associated virus serotype 9 (AAV9) gene therapy vector or recombinant protein, resulted in a complete arrest of folliculogenesis in mice. Read More

    Successful treatment of anti-NMDA receptor encephalitis with a prompt ovarian tumour removal and prolonged course of plasmapheresis: A case report.
    Mol Clin Oncol 2016 Dec 19;5(6):845-849. Epub 2016 Oct 19.
    The Second Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, Lublin, Poland.
    Anti-N-methyl-d-aspartate-receptor (NMDAR) encephalitis is an uncommon autoimmune disorder with a wide spectrum of neuropsychiatric symptoms. There is a great requirement to emphasize the importance of a multidisciplinary team approach in the process of diagnosis and treatment of the potentially fatal condition, including psychiatrists, neurologists, gynaecologists and intensivists. Physicians must be aware that psychiatric and neurological disorders, which are typical features for NMDAR encephalitis in young women with ovarian tumours, may progress into status epilepticus and respiratory insufficiency. Read More

    Pulse wave velocity and myocardial performance index in premature ovarian insufficiency.
    Scand Cardiovasc J 2017 Apr 7;51(2):95-98. Epub 2017 Feb 7.
    a Department of Cardiology , Sakarya University Research and Training Hospital , Sakarya , Turkey.
    Objective: Epidemiological studies suggest that women with loss of ovarian function at early ages may be especially burdened by cardiovascular disease (CVD). In this study, we aimed to evaluate pulse wave velocity (PWV) and myocardial performance index (MPI) in patients with premature ovarian insufficiency (POI).

    Design: We enrolled 51 female patients (mean age 38. Read More

    BMP15 "knockout-like" effect in familial premature ovarian insufficiency with persistent ovarian reserve.
    Clin Genet 2017 Jan 17. Epub 2017 Jan 17.
    Faculté de Médecine Paris Sud, Université Paris Sud, Université Paris Saclay, Le Kremlin Bicêtre, France.
    Premature ovarian insufficiency (POI) affects 1% to 2% of women under 40 years. Bone morphogenetic protein 15 (BMP15) variants have been described in POI. We studied a family with 2 sisters compound heterozygous for deletions in the BMP15 gene on chromosome Xp11. Read More

    In Vitro Fertilization in 37 Women with Systemic Lupus Erythematosus or Antiphospholipid Syndrome: A Series of 97 Procedures.
    J Rheumatol 2017 Jan 15. Epub 2017 Jan 15.
    From the Centre de compétence de maladies auto-immunes et systémiques rares, Service de médecine interne, Hôpital Robert Debré, Centre Hospitalier Universitaire (CHU), Reims Cedex; Service de médecine interne, CHU, Nantes; Université René Descartes Paris V, Centre de référence maladies auto-immunes et systémiques rares, Service de médecine interne, Hôpital Cochin, AP-HP; Service de gynécologie-obstétrique, Hôpital Cochin, AP-HP; Service de gynécologie-obstétrique, Groupe Hospitalier Pitié Salpêtrière, AP-HP; Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B); INSERM, UMR_S 959, F-75013; CNRS, FRE3632, F-75005; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Paris, France. P. Orquevaux, MD, Centre de compétence de maladies auto-immunes et systémiques rares, Service de médecine interne, Hôpital Robert Debré, CHU; A. Masseau, MD, Service de médecine interne, CHU; V. Le Guern, MD, Université René Descartes Paris V, Centre de référence maladies auto-immunes et systémiques rares, Service de médecine interne, Hôpital Cochin, AP-HP; V. Gayet, MD, Service de gynécologie-obstétrique, Hôpital Cochin, AP-HP; D. Vauthier, MD, Service de gynécologie-obstétrique, Groupe Hospitalier Pitié Salpêtrière, AP-HP; G. Guettrot-Imbert, MD, Université René Descartes Paris V, Centre de référence maladies auto-immunes et systémiques rares, Service de médecine interne, Hôpital Cochin, AP-HP; D.L. Huong, MD, Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), and INSERM, UMR_S 959, F-75013, and CNRS, FRE3632, F-75005, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; B. Wechsler, MD, PhD, Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), and INSERM, UMR_S 959, F-75013, and CNRS, FRE3632, F-75005, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; N. Morel, MD, Université René Descartes Paris V, Centre de référence maladies auto-immunes et systémiques rares, Service de médecine interne, Hôpital Cochin, AP-HP; P. Cacoub, MD, PhD, Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), and INSERM, UMR_S 959, F-75013, and CNRS, FRE3632, F-75005, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; J.L. Pennaforte, MD, PhD, Centre de compétence de maladies auto-immunes et systémiques rares, Service de médecine interne, Hôpital Robert Debré, CHU; J.C. Piette, MD, PhD, Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), and INSERM, UMR_S 959, F-75013, and CNRS, FRE3632, F-75005, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; N. Costedoat-Chalumeau, MD, PhD, Université René Descartes Paris V, Centre de référence maladies auto-immunes et systémiques rares, Service de médecine interne, Hôpital Cochin, AP-HP. Address correspondence to Dr. N. Costedoat-Chalumeau, Centre de référence maladies auto-immunes et systémiques rares, Service de médecine interne, Hôpital Cochin, AP-HP, 27 rue du Faubourg Saint Jacques, 75679 Paris cedex 14, France. E-mail: Accepted for publication November 25, 2016.
    Objective: To compile and assess data about complication and success rates for in vitro fertilization (IVF) of women with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS). To date, such data are sparse.

    Methods: This retrospective study described women with SLE and/or APS who have had at least 1 IVF cycle. Read More

    Quantifying growing versus non-growing ovarian follicles in the mouse.
    J Ovarian Res 2017 Jan 13;10(1). Epub 2017 Jan 13.
    Department of Obstetrics and Gynecology, University of Colorado-Denver, Building RC2, Room P15 3103, Aurora, 80045, Colorado, USA.
    Background: A standard histomorphometric approach has been used for nearly 40 years that identifies atretic (e.g., dying) follicles by counting the number of pyknotic granulosa cells (GC) in the largest follicle cross-section. Read More

    The correlation of age with chemotherapy-induced ovarian function failure in breast cancer patients.
    Oncotarget 2017 Feb;8(7):11372-11379
    Department of Medical Oncology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
    Purpose: To assess the incidence of chemotherapy-induced ovarian function failure (COFF) based on estradiol and follicle stimulating hormone (FSH) monitoring in premenopausal women with hormone-receptor positive breast cancer treated with second and third generation (neo-)adjuvant chemotherapy.

    Results: We identified 115 eligible women. Two years after start of chemotherapy, COFF was significantly more often present in women ≥ 40 years (85. Read More

    Premature ovarian insufficiency and perinatal parameters: A retrospective case-control study.
    Maturitas 2017 Feb 26;96:72-76. Epub 2016 Nov 26.
    Division of Reproductive Medicine, Department of Obstetrics & Gynecology, VU University Medical Center (VUMC), Amsterdam, The Netherlands.
    Objective: The peak number of oocytes is reached during intrauterine development, after which numbers decline until reserves are depleted and a woman enters menopause. In premature ovarian insufficiency (POI), the process of follicle depletion occurs at a young age (generally taken as 40 years); the condition affects about 1% of women. In this study, we investigate whether women with POI had experienced a different perinatal milieu, as reflected in their birth weight or prematurity. Read More

    Wide spectrum of NR5A1-related phenotypes in 46,XY and 46,XX individuals.
    Birth Defects Res C Embryo Today 2016 12;108(4):309-320
    Sorahia Domenice, Aline Zamboni Machado, Bruno Ferraz-de-Souza, Antonio Marcondes Lerario, Mirian Yumie Nishi, Nathalia Lisboa Gomes, Thatiana Evelin da Silva, Rosana Barbosa Silva, Luciana R. Montenegro, Amanda Narciso, Elaine Maria Frade Costa, and Berenice Bilharinho Mendonca are from the Laboratório de Hormônios e Genética Molecular (LIM/42), Unidade de Endocrinologia do Desenvolvimento, Disciplina de Endocrinologia e Metabologia do Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil.
    Steroidogenic factor 1 (NR5A1, SF-1, Ad4BP) is a transcriptional regulator of genes involved in adrenal and gonadal development and function. Mutations in NR5A1 have been among the most frequently identified genetic causes of gonadal development disorders and are associated with a wide phenotypic spectrum. In 46,XY individuals, NR5A1-related phenotypes may range from disorders of sex development (DSD) to oligo/azoospermia, and in 46,XX individuals, from 46,XX ovotesticular and testicular DSD to primary ovarian insufficiency (POI). Read More

    SF1 and spleen development: new heterozygous mutation, literature review and consequences for NR5A1-mutated patient's management.
    Clin Genet 2016 Dec 29. Epub 2016 Dec 29.
    CHU Lille, Clinique de Génétique Guy Fontaine, Lille, France.
    Steroidogenic factor 1 (encoded by SF1/NR5A1) is a transcription factor with multiple target genes involved in the development and function of multiple steroidogenic and non-steroidogenic tissues. NR5A1 mutations lead to several phenotypes, including sex reversal, spermatogenesis failure, premature ovarian failure and adrenocortical insufficiency. The implication of NR5A1 mutations in spleen development anomalies was recently highlighted. Read More

    86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children.
    J Assist Reprod Genet 2017 Mar 27;34(3):325-336. Epub 2016 Dec 27.
    The Laboratory of Reproductive Biology, Section 5712, Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen, University of Copenhagen, Blegdamsvej 9, Rigshospitalet, DK-2100, Copenhagen, Denmark.
    Purpose: This study aims to make an account of the children born following transplantation of frozen-thawed ovarian tissue worldwide with specific focus on the perinatal outcome of the children. Furthermore, perinatal outcome of seven deliveries (nine children) from Denmark is reported.

    Methods: PubMed was searched for papers of deliveries resulting from ovarian tissue cryopreservation (OTC). Read More

    Restoring Ovarian Endocrine Function with Encapsulated Ovarian Allograft in Immune Competent Mice.
    Ann Biomed Eng 2016 Dec 27. Epub 2016 Dec 27.
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
    Premature ovarian insufficiency (POI) is a major complication of cytotoxic treatments due to extreme ovarian sensitivity to chemotherapy and radiation. In pediatric cancer patients modern therapy has improved the long-term survival to over 80% in the United States. However, these cancer survivors face long-term health problems related to treatment toxicity. Read More

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