3,746 results match your criteria Ovarian Insufficiency


A truncating MEIOB mutation responsible for familial primary ovarian insufficiency abolishes its interaction with its partner SPATA22 and their recruitment to DNA double-strand breaks.

EBioMedicine 2019 Apr 15. Epub 2019 Apr 15.

Institut Jacques Monod, Université Paris Diderot, CNRS UMR7592, Paris 75013, France; Université Paris Diderot-Paris 7, 75205 Paris Cedex 13, France. Electronic address:

Background: Primary Ovarian Insufficiency (POI), a major cause of infertility, affects about 1-3% of women under forty years of age. Although there is a growing list of causal genetic alterations, POI remains mostly idiopathic.

Methods: We performed exome sequencing (WES) of two sisters affected with POI, one unaffected sister and their mother from a consanguineous family. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.03.075DOI Listing

Mutational analysis of theFAM175A gene in patients with premature ovarian insufficiency.

Reprod Biomed Online 2019 Feb 28. Epub 2019 Feb 28.

Centre for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, China. Electronic address:

Research Question: The family with sequence similarity 175 member A gene (FAM175A; also known as ABRAXAS1, CCDC98 and ABRA1), a member of the DNA repair family, contributes to the BRCA1 (BRCA1 DNA repair associated)-dependent DNA damage response and is associated with age at natural menopause. However, it remains poorly understood whether sequence variants in FAM175A are causative for premature ovarian insufficiency (POI). The aim of this study was to investigate whether mutations in the gene FAM175A were present in patients with POI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14726483193010
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http://dx.doi.org/10.1016/j.rbmo.2019.02.006DOI Listing
February 2019
1 Read

Feasibility of transabdominal Doppler ultrasonography for studying ovarian blood flow characteristics in cycling gilts.

Tierarztl Prax Ausg G Grosstiere Nutztiere 2019 Apr 18;47(2):77-85. Epub 2019 Apr 18.

Clinic for Ruminants and Swine, Faculty of Veterinary Medicine, University of Leipzig.

Objective: The aim of this study was to assess ovarian blood flow characteristics by applying transabdominal color Doppler ultrasonography during the course of the estrous cycle in gilts.

Materials And Methods: Estrus and ovulation were synchronized in 15 pubertal gilts. During their consecutive spontaneous estrous cycle the gilts were sonographically scanned daily and ovarian blood flow was determined by imaging perfused areas of the ovarian hilus and the ovarian tissue. Read More

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http://dx.doi.org/10.1055/a-0858-0076DOI Listing

Reality of premature ovarian failure in Argentina.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):419-423. Epub 2019 Apr 11.

Argentinian Society of Gynecological and Reproductive Endocrinology, Buenos Aires, Argentina.

Premature Ovarian Insufficiency is defined as a decline in ovarian function that is accompanied by two biochemical determinations of Follicle Stimulating Hormone in hypergonadotropic values, in addition to low levels of circulating estrogens in women under 40 years old. Although some of its possible etiologies are recognized and diagnosed, most of the time, its cause remains unknown. It is a pathology with medical, psychological, and reproductive implications. Read More

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http://dx.doi.org/10.1590/1806-9282.65.3.419DOI Listing
March 2019
1 Read

[Clinical efficacy of Bushen Culuan Decoction in treating infertility due to premature ovarian insufficiency].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(6):1075-1079

Dezhou United Hospital Dezhou 253000,China.

To analyze the clinical efficiency of traditional Chinese medicine( TCM) Bushen Culuan Decoction in treating anovulatory infertility due to premature ovarian insufficiency( POI). A total of 90 eligible cases were randomly divided into experimental group and control group. The 45 cases in the experimental group took Bushen Culuan Decoction,while the other 45 cases in the control group took estradiol valerate( Progynova),clomiphene( Clomiphene Citrate tablet) and progesterone. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181225.005DOI Listing
March 2019
1 Read

Decreased effector regulatory T cells and increased activated CD4 T cells in premature ovarian insufficiency.

Am J Reprod Immunol 2019 Apr 11:e13125. Epub 2019 Apr 11.

Department of Obstetrics and Gynecology, University of Toyama, Toyama, 930-0152, Japan.

Problem: Premature ovarian insufficiency (POI) is a clinical syndrome defined by the loss of ovarian activity before 40 years of age. An autoimmune mechanism is suggested to be involved in the development of POI. Therefore, we examined the relationship between peripheral blood regulatory T (Treg) cells and autoantibodies in POI. Read More

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http://dx.doi.org/10.1111/aji.13125DOI Listing
April 2019
1 Read

A high-resolution X chromosome copy-number variation map in fertile females and women with primary ovarian insufficiency.

Genet Med 2019 Apr 5. Epub 2019 Apr 5.

Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.

Purpose: Sex-biased expression of genes on the X chromosome is accomplished by a complex mechanism of dosage regulation that leads to anatomical and physiological differences between males and females. Copy-number variations (CNVs) may impact the human genome by either affecting gene dosage or disturbing a chromosome structural and/or functional integrity.

Methods: We performed a high-resolution CNV profiling to investigate the X chromosome integrity in cohorts of 269 fertile females and 111 women affected with primary ovarian insufficiency (POI) and assessed CNVs impact into functional and nonfunctional genomic elements. Read More

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http://www.nature.com/articles/s41436-019-0505-2
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http://dx.doi.org/10.1038/s41436-019-0505-2DOI Listing
April 2019
10 Reads

Incidence and distribution of lower extremity reflux in patients with pelvic venous insufficiency.

Phlebology 2019 Apr 3:268355519840846. Epub 2019 Apr 3.

1 Center for Vein Restoration, Greenbelt, MD, USA.

Introduction: Women with pelvic venous insufficiency often present with lower extremity symptoms and manifestations of chronic venous disorders. The purpose of this investigation was to determine the incidence of lower extremity chronic venous disorders and the types and distribution of lower extremity veins involved in patients with a known diagnosis of pelvic venous insufficiency.

Methods: Between January 2012 and December 2015, we retrospectively reviewed the charts of 227 women with pelvic venous insufficiency as well as their lower extremity venous duplex investigations. Read More

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http://dx.doi.org/10.1177/0268355519840846DOI Listing
April 2019
2 Reads

TP63-truncating variants cause isolated premature ovarian insufficiency.

Hum Mutat 2019 Mar 29. Epub 2019 Mar 29.

Reproductive Development, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.

Premature ovarian insufficiency involves amenorrhea and elevated follicle-stimulating hormone before age 40, and its genetic basis is poorly understood. Here, we study 13 premature ovarian insufficiency (POI) patients using whole-exome sequencing. We identify PREPL and TP63 causative variants, and variants in other potentially novel POI genes. Read More

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http://dx.doi.org/10.1002/humu.23744DOI Listing
March 2019
1 Read

Successful pregnancy with tripterygium glycoside-induced premature ovarian insufficiency: a case report.

J Int Med Res 2019 Mar 28:300060519837834. Epub 2019 Mar 28.

Key Laboratory for Reproductive Medicine and Embryology, The Reproductive Medicine Special Hospital of the First Hospital of Lanzhou University, Lanzhou, Gansu Province, China.

Premature ovarian insufficiency is characterized by reduced ovarian function in a young woman, resulting in an earlier menopause compared with women with normal ovarian function. It is a term that reflects the variable nature of the condition and is substantially less emotive than the formerly used 'premature ovarian failure', which suggested a single event in time. Tripterygium glycosides can damage ovarian function and cause infertility. Read More

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http://dx.doi.org/10.1177/0300060519837834DOI Listing
March 2019
1 Read

Should single embryo transfer be used in patients with any kind of infertility factor? Preliminary outcomes.

JBRA Assist Reprod 2019 Mar 25. Epub 2019 Mar 25.

Centro de Reprodução Humana Monteleone, São Paulo - Brazil.

Objective: Multiple embryos have been transferred to compensate for low implantation rates, which in turn, increase the likelihood of multiple pregnancies. Despite the publication of clinical guidelines and a reduction in the number of embryos transferred, double embryo transfer still is the most common practice. There is no clear evidence of who should receive the single embryo transfer (SET), and it is more commonly indicated for patients of good prognosis. Read More

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http://dx.doi.org/10.5935/1518-0557.20190006DOI Listing
March 2019
1 Read

Sexuality in premature ovarian insufficiency.

Climacteric 2019 Mar 22:1-7. Epub 2019 Mar 22.

a Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, Obstetrics and Gynecology Unit, IRCCS S. Matteo Foundation, Department of Clinical, Surgical, Diagnostic and Paediatric Sciences , University of Pavia , Pavia , Italy.

Sexuality in women with spontaneous premature ovarian insufficiency (POI) deserves attention because of the young age and the distressing impact of such a life-changing diagnosis. Biomedical and psychosocial factors work in concert to determine significant changes of sexual function. Early hormonal deprivation gives origin to symptomatic vulvovaginal atrophy and contributes to hypoactive sexual desire disorder modulating central and peripheral circuitries, which regulate sexual response. Read More

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http://dx.doi.org/10.1080/13697137.2019.1575356DOI Listing
March 2019
6 Reads

Pathophysiology Mechanisms in Fragile-X Primary Ovarian Insufficiency.

Methods Mol Biol 2019 ;1942:165-171

IVF unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan, Israel.

Women who carry the FMR1 premutation may suffer from ongoing deterioration of ovarian function. The lucidity of the molecular mechanism of FXTAS is emerging and findings from research in the field of FXTAS could elucidate the pathogenesis of FXPOI. To date there are three possible mechanisms for ovarian dysfunction in FMR1 permutation carriers. Read More

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http://dx.doi.org/10.1007/978-1-4939-9080-1_14DOI Listing
January 2019
1 Read

Assays for Determining Repeat Number, Methylation Status, and AGG Interruptions in the Fragile X-Related Disorders.

Methods Mol Biol 2019 ;1942:49-59

Section on Gene Structure and Disease, Laboratory of Cell and Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

Knowledge of the CGG•CCG-repeat number, AGG interruption status, and the extent of DNA methylation of the FMR1 gene are vital for both diagnosis of the fragile X-related disorders and for basic research into disease mechanisms. We describe here assays that we use in our laboratory to assess these parameters. Our assays are PCR-based and include one for repeat size that can also be used to assess the extent of methylation and a related assay that allows the AGG interruption pattern to be reliably determined even in women. Read More

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http://dx.doi.org/10.1007/978-1-4939-9080-1_4DOI Listing
January 2019
1 Read

Fragile X Syndrome: Introduction.

Authors:
Adi Reches

Methods Mol Biol 2019 ;1942:3-10

Genetic Institute and Racine IVF Unit at Lis Maternity Hospital Tel Aviv, Sackler Faculty of Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.

Fragile X syndrome (FXS) is one of the most common reasons for intellectual disability (ID). First described in the 1940s, it took many years to understand the disease. The awe-inspiring breakthroughs in both science and technology facilitated the recognition of the unique inheritance pattern and the genetic mechanism of fragile X. Read More

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http://dx.doi.org/10.1007/978-1-4939-9080-1_1DOI Listing
January 2019
1 Read

Adipose-derived stem cells promote survival, growth, and maturation of early-stage murine follicles.

Stem Cell Res Ther 2019 Mar 21;10(1):102. Epub 2019 Mar 21.

Department of Biomedical Engineering, University of Michigan, 2126 Lurie Biomedical Engineering Building, 1101 Beal Ave., Ann Arbor, MI, 48109, USA.

Background: Premature ovarian insufficiency is a common complication of anticancer treatments in young women and girls. The ovary is a complex, highly regulated reproductive organ, whose proper function is contingent upon the bidirectional endocrine, paracrine, and autocrine signaling. These factors facilitate the development of the follicles, the functional units of the ovary, to progress from the gonadotropin-independent, paracrine-controlled early stage to the gonadotropin-dependent, endocrine-controlled later stage. Read More

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http://dx.doi.org/10.1186/s13287-019-1199-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427888PMC
March 2019
2 Reads

To Freeze or Not to Freeze? An Update on Fertility Preservation In Females with Turner Syndrome.

Pediatr Endocrinol Rev 2019 03;16(3):369-382

Department of Obstetrics and Gynaecology, Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

Introduction Infertility is a major concern for females with Turner syndrome (TS), regardless of their age. While fertility preservation is now routinely offered to girls and young women with cancer, there are currently no recommendations on fertility preservation in girls and young women with TS who generally face an even higher risk for infertility. Despite the lack of international guidelines, preservation procedures have been performed experimentally in females with TS. Read More

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http://dx.doi.org/10.17458/per.vol16.2019.svb.tofreezeornotDOI Listing
March 2019
2 Reads

Ovarian Function and Fertility Preservation in Breast Cancer: Should Gonadotropin-Releasing Hormone Agonist be administered to All Premenopausal Patients Receiving Chemotherapy?

Clin Med Insights Reprod Health 2019 9;13:1179558119828393. Epub 2019 Mar 9.

Centro de Cancer de Mama del Hospital Zambrano Hellion, Tecnologico de Monterrey, Nuevo Leon, Mexico.

Chemotherapy-induced premature ovarian insufficiency (POI) is one of the potential drawbacks of chemotherapy use of particular concern for newly diagnosed premenopausal breast cancer patients. Temporary ovarian suppression obtained pharmacologically with the administration of a gonadotropin-releasing hormone agonist (GnRHa) during chemotherapy has been specifically developed as a method to counteract chemotherapy-induced gonadotoxicity with the main goal of diminishing the risk of POI. In recent years, important clinical evidence has become available on the efficacy and safety of this strategy that should now be considered a standard option for ovarian function preservation in premenopausal breast cancer patients, including women who are not interested in conceiving after treatment or that would not be candidates for fertility preservation strategies because of their age. Read More

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http://dx.doi.org/10.1177/1179558119828393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410390PMC
March 2019
2 Reads

Comparing the role of anti-Müllerian hormone as a marker of FSH action in male and female fertility.

Expert Rev Endocrinol Metab 2019 Mar 4:1-12. Epub 2019 Mar 4.

a Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE), CONICET - FEI - División de Endocrinología , Hospital de Niños Ricardo Gutiérrez , Buenos Aires , Argentina.

Introduction: Originally limited to the assessment of disorders of sex development, anti-Müllerian hormone (AMH) measurement has more recently been extended to several conditions affecting the reproductive axis in males and females. Follicle-stimulating hormone (FSH) regulation of gonadal function has been extensively studied, but its role on AMH production has been explored only recently. Areas covered: We addressed the relationship between FSH action on the gonads and the usefulness of AMH as a marker in conditions affecting the reproductive axis. Read More

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http://dx.doi.org/10.1080/17446651.2019.1590197DOI Listing
March 2019
2 Reads

suppression during the murine fetal period optimizes ovarian development by fine-tuning Notch signaling.

J Cell Sci 2019 Apr 15;132(8). Epub 2019 Apr 15.

Department of Pediatrics and Developmental Biology, Tokyo Medical Dental University, Tokyo 113-8510, Japan.

The nuclear receptor NR5A1 is equally expressed and required for development of the gonadal primordia of both sexes, but, after sex determination, it is upregulated in XY testes and downregulated in XX ovaries. We have recently demonstrated, in mice, that this downregulation is mediated by forkhead box L2 (FOXL2) and hypothesized that adequate suppression of is essential for normal ovarian development. Further, analysis of human patients with disorders/differences of sex development suggests that overexpression of can result in XX (ovo)testicular development. Read More

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http://dx.doi.org/10.1242/jcs.223768DOI Listing
April 2019
3 Reads
5.432 Impact Factor

Treatment potential of bone marrow-derived stem cells in women with diminished ovarian reserves and premature ovarian failure.

Curr Opin Obstet Gynecol 2019 Feb 21. Epub 2019 Feb 21.

Fundación IVI.

Purpose Of Review: We review the techniques recently tested in both animal models and humans to provide a state-of-the-art on adult stem cell ovarian transplant to achieve ovarian rejuvenation in patients with diminished ovarian reserves.

Recent Findings: As the firsts reports of spontaneous pregnancies achieved after bone marrow transplantation in oncologic women with primary ovarian insufficiency, increasing evidence supports the regenerative effects of stem cell-based therapies in the ovarian niche. Adult stem cells from several origins promote follicular development, increase ovarian local vascularization, increase follicle and stromal cell proliferation and reduce cell apoptosis and follicular atresia, although they do not modify embryo quality. Read More

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http://dx.doi.org/10.1097/GCO.0000000000000531DOI Listing
February 2019
3 Reads

[Embolization of insufficient pelvic veins for pelvic congestion syndrome. Analysis of 17 cases].

Rev Med Chil 2019 ;147(1):41-46

Departamento de Cirugía Vascular y Endovascular, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Pelvic venous insufficiency may cause pelvic congestion syndrome that is characterized by chronic pelvic pain exacerbated by prolonged standing, sexual activity or menstrual cycle. It may be treated by embolizing the dysfunctional pelvic venous drainage and sometimes resecting vulvar, perineal and thigh varices.

Aim: To assess the results of embolization of insufficient pelvic or ovarian veins on pelvic congestion syndrome. Read More

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http://dx.doi.org/10.4067/S0034-98872019000100041DOI Listing
March 2019
10 Reads

Triplet-Repeat Primed PCR and Capillary Electrophoresis for Characterizing the Fragile X Mental Retardation 1 CGG Repeat Hyperexpansions.

Methods Mol Biol 2019 ;1972:199-210

Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Fragile X mental retardation 1 (FMR1) CGG repeat expansions cause fragile X syndrome-the leading monogenic form of intellectual disability-and increase the risk for fragile X-associated tremor ataxia syndrome and fragile X-associated primary ovarian insufficiency. Southern blot (SB) analysis is the current gold standard test for FMR1 molecular diagnosis. Several polymerase chain reaction (PCR)-based methods are now available for sizing FMR1 CGG repeat expansions. Read More

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http://dx.doi.org/10.1007/978-1-4939-9213-3_14DOI Listing
January 2019
3 Reads

Exome sequencing reveals POLR3H gene as a novel cause of Primary Ovarian Insufficiency.

J Clin Endocrinol Metab 2019 Mar 4. Epub 2019 Mar 4.

Unidade de Endocrinologia do Desenvolvimento, Laboratorio de Hormonios e Genetica Molecular/ LIM42, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Univer sidade de Sao Paulo, Sao Paulo, SP, BR.

Context: Primary ovarian insufficiency (POI) is a cause of female infertility. However, the genetic etiology of this disorder remains unknown in most POI patients.

Objective: To investigate the genetic etiology of idiopathic POI. Read More

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http://dx.doi.org/10.1210/jc.2018-02485DOI Listing
March 2019
6 Reads
6.209 Impact Factor

The global prevalence of primary ovarian insufficiency and early menopause: a meta-analysis.

Climacteric 2019 Mar 4:1-9. Epub 2019 Mar 4.

e Midwifery and Reproductive Health Research Center and Department of Midwifery and Reproductive Health, School of Nursing and Midwifery , Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Objective: The aim of this study was to estimate the global prevalence of primary ovarian insufficiency (POI) and early menopause (EM).

Methods: A comprehensive literature search was performed in several databases to retrieve relevant English articles published between 1980 and 2017. To assess the methodological quality of the studies, the Newcastle-Ottawa Scale was used. Read More

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http://dx.doi.org/10.1080/13697137.2019.1574738DOI Listing
March 2019
2 Reads

Mesenchymal stem cells for restoration of ovarian function.

Authors:
Sook Young Yoon

Clin Exp Reprod Med 2019 Mar 1;46(1):1-7. Epub 2019 Mar 1.

Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, Korea.

With the progress of regenerative medicine, mesenchymal stem cells (MSCs) have received attention as a way to restore ovarian function. It has been reported that MSCs derived from bone marrow, adipose, umbilical cord blood, menstrual blood, and amniotic fluid improved ovarian function. In light of previous studies and advances in this field, there are increased expectations regarding the utilization of MSCs to restore ovarian function. Read More

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http://dx.doi.org/10.5653/cerm.2019.46.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436469PMC
March 2019
4 Reads

Adjuvant gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in premenopausal women.

Cochrane Database Syst Rev 2019 03 3;3:CD008018. Epub 2019 Mar 3.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 17, Section Three, Ren Min Nan Lu Avenue, Chengdu, Sichuan, China, 610041.

Background: This is an update of the original review published in the Cochrane Database of Systematic Reviews 2011, Issue 11, and updated in 2015, Issue 4.Chemotherapy has significantly improved prognosis for women with malignant and some non-malignant conditions. This treatment, however, is associated with ovarian toxicity. Read More

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http://dx.doi.org/10.1002/14651858.CD008018.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397718PMC
March 2019
1 Read

A critical assessment of case reports describing absent uterus in subjects with oestrogen deficiency.

Clin Endocrinol (Oxf) 2019 Feb 28. Epub 2019 Feb 28.

Reproductive Medicine Unit, Institute for Women's Health, University College London Hospitals, London, UK.

Objective: The dual diagnosis of hypoplastic uterus in association with ovarian dysgenesis is regularly reported but the pathogenesis of the association is unclear. The uterus, however, may be invisible to all imaging modalities without at least six months of exogenous oestrogen exposure in complete ovarian failure. We assessed all available case reports in this category to estimate whether the apparent association between primary ovarian insufficiency or Turner syndrome and Mullerian agenesis can be largely accounted for by oestrogen deficiency. Read More

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http://dx.doi.org/10.1111/cen.13963DOI Listing
February 2019
2 Reads

Siblings with lethal primary pulmonary hypoplasia and compound heterozygous variants in the gene: further delineation of the phenotypic spectrum.

Cold Spring Harb Mol Case Stud 2019 Feb 28. Epub 2019 Feb 28.

Yale University School of Medicine;

Variants in the mitochondrial alanyl-tRNA synthetase 2 gene (OMIM 612035) are associated with infantile mitochondrial cardiomyopathy or later-onset leukoencephalopathy with premature ovarian insufficiency. Here, we report two newborn siblings who died soon after birth with primary pulmonary hypoplasia without evidence of cardiomyopathy. Whole exome sequencing detected the same compound heterozygous variants in both siblings (c. Read More

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http://dx.doi.org/10.1101/mcs.a003699DOI Listing
February 2019
3 Reads

Premature Ovarian Insufficiency and Long-Term Health Consequences.

Curr Vasc Pharmacol 2019 Jan 21. Epub 2019 Jan 21.

National Heart & Lung Institute, Imperial College London, Royal Brompton Hospital, London. United Kingdom.

Premature ovarian insufficiency (POI) is defined as the cessation of ovarian function before the age of 40 years. The trio of amenorrhea, elevated gonadotropins and oestrogen deficiency is associated with long-term health consequences including increased cardiovascular disease (CVD), decreased bone mineral density (BMD), significantly reduced fertility, psychological distress, vulvovaginal atrophy, neurological effects and overall reduced life expectancy. There are deficits in our understanding of this condition and subsequently the long-term health consequences. Read More

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http://dx.doi.org/10.2174/1570161117666190122101611DOI Listing
January 2019
2 Reads

Effect of lycopene on oxidative ovarian damage induced by cisplatin in rats.

Gen Physiol Biophys 2019 Feb 26. Epub 2019 Feb 26.

Erzincan University Medical Faculty, Gynaecology and Obstetrics Department, Erzincan, Turkey.

The anti-cancer drugs, particularly those used in reproductive period, may cause several complications such as ovarian insufficiency and infertility. The mechanism of action of cisplatin toxicity on the ovaries is not fully described. However, further production of free oxygen radicals and reduced production of antioxidants are thought to have an effect on the occurrence of cisplatin toxicity. Read More

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http://dx.doi.org/10.4149/gpb_2019006DOI Listing
February 2019

Successful Implantation and Live Birth Following Autologous Platelet-rich Plasma Treatment for a Patient with Recurrent Implantation Failure and Chronic Endometritis.

In Vivo 2019 Mar-Apr;33(2):515-521

Reproductive Medicine Unit, Genesis Athens Clinic, Athens, Greece.

Background/aim: Patients diagnosed with chronic endometritis (CE) may fail to respond to standard antibiotic treatment. The driver behind the approach reported here was the imperative need for alternative therapeutic solutions.

Case Report: This case report presents a woman with CE and premature ovarian insufficiency having experienced repeated implantation failures following donated embryo transfers. Read More

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http://dx.doi.org/10.21873/invivo.11504DOI Listing
November 2018
1 Read

Can Pregnancies Be Achieved in Premature Ovarian Insufficiency?

Reprod Sci 2019 02;26(2):157-158

1 Department of Obstetrics and Gynecology, Florida International University Herbert Wertheim College of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1177/1933719118823597DOI Listing
February 2019

Iatrogenic and non-iatrogenic causes of female fertility loss that may indicate fertility preservation.

Acta Obstet Gynecol Scand 2019 May 28;98(5):559-562. Epub 2019 Mar 28.

Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Netherlands.

Due to advances in fertility preservation options and improvements in life expectancy, there is growing need for fertility preservation counseling for women at risk for premature ovarian insufficiency. The aim of this review is to provide an overview of various causes of female fertility loss and to raise awareness for counseling women about their options for fertility preservation. Furthermore, for counseling of women not only at the time of gonadotoxic treatment but also post-treatment and also of women with other benign causes of increased risk for impaired fertility or premature ovarian insufficiency. Read More

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http://dx.doi.org/10.1111/aogs.13594DOI Listing
May 2019
2 Reads

Case series of infertility amongst young women with perinatally acquired HIV: data from a London cohort.

J Virus Erad 2019 Jan 1;5(1):44-46. Epub 2019 Jan 1.

Imperial College London, UK.

Introduction: Increased rates of infertility have been reported in women who acquired HIV horizontally compared to population age-matched normative data. However, few data exist for adults with perinatally acquired HIV (PaHIV), who have been exposed to antiretroviral drugs and/or HIV-associated ill health through childhood and puberty. We describe a case series of infertility amongst women with PaHIV attending a London clinic between 2006 and 2017. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362900PMC
January 2019
1 Read

Recommendations for assessing ovarian health and fertility potential in survivors of childhood cancer.

Maturitas 2019 Apr 25;122:57-59. Epub 2019 Jan 25.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Colorado Denver, 12631 East 17th Avenue, Mail Stop B198-3, Academic Office 1, United States.

Most children diagnosed with cancer survive for many years after treatment. However, the fertility potential of these patients may suffer due to their oncologic therapies. Certain chemotherapies and radiation are more likely to be detrimental to gonadal function, and put patients at risk of acute or premature ovarian failure. Read More

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http://dx.doi.org/10.1016/j.maturitas.2019.01.009DOI Listing
April 2019
2 Reads

Diminished Ovarian Reserve Chemotherapy-Induced Mouse Model: A Tool for the Preclinical Assessment of New Therapies for Ovarian Damage.

Reprod Sci 2019 Feb 21:1933719119831784. Epub 2019 Feb 21.

1 IVI Foundation, Valencia Spain.

Diminished ovarian reserve (DOR) and primary ovarian insufficiency (POI) are primary factors leading to infertility. However, there is a lack of appropriate animal models of DOR usable for assessing new therapeutic strategies. In this study, we aimed to evaluate whether chemotherapy treatment in mice could reproduce features similar of that observed in women with DOR. Read More

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http://dx.doi.org/10.1177/1933719119831784DOI Listing
February 2019
2 Reads

Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities.

Proc Natl Acad Sci U S A 2019 Feb 19. Epub 2019 Feb 19.

Department of Cancer Biology and Genetics, Ohio State University, Columbus, OH 43210;

Endometrioid endometrial carcinomas (EECs) carry multiple driver mutations even when they are low grade. However, the biological significance of these concurrent mutations is unknown. We explored the interactions among three signature EEC mutations: loss-of-function (LOF) mutations in , gain-of-function (GOF) mutations of phosphoinositide 3-kinase (PI3K), and exon 3 mutations, utilizing in vivo mutagenesis of the mouse uterine epithelium. Read More

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http://dx.doi.org/10.1073/pnas.1814506116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410785PMC
February 2019
10 Reads
9.809 Impact Factor

Laparoscopic unilateral oophorectomy for ovarian tissue cryopreservation in children.

J Pediatr Surg 2019 Mar 9;54(3):543-549. Epub 2018 Jun 9.

Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Pediatric Surgery, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.

Background/purpose: Many survivors of childhood cancer will experience premature gonadal insufficiency or infertility as a consequence of their medical treatments. Ovarian tissue cryopreservation (OTC) remains an experimental means of fertility preservation with few reports focused on the surgical technique and postoperative outcomes for OTC in children.

Methods: This is a single institution, retrospective review of OTC cases from January 2011 to December 2017. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383797PMC
March 2019
4 Reads

Fertility and hormone preservation and restoration for female children and adolescents receiving gonadotoxic cancer treatments: A systematic review.

J Pediatr Surg 2019 Jan 22. Epub 2019 Jan 22.

Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Pediatric Surgery, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA. Electronic address:

Background/purpose: The purpose of this systematic review by the American Pediatric Surgical Cancer Committee was to summarize evidence from the current medical literature regarding fertility restoration and hormone replacement for female children and adolescents treated with gonadotoxic treatments.

Methods: Using PRISMA guidelines, questions were addressed by searching Medline, Cochrane, Embase Central and National clearing house databases using relevant search terms. Eligible studies included those that addressed ovarian tissue cryopreservation (OTC), oocyte harvest, ovarian transposition, and ovarian tissue auto-transplantation for females under the age of 20. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.12.021DOI Listing
January 2019

Oocyte cryopreservation for a female cancer patient after reaching adulthood.

Pediatr Int 2019 Feb 11;61(2):207-208. Epub 2019 Feb 11.

Departments of Human Health Science, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto, Japan.

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http://dx.doi.org/10.1111/ped.13752DOI Listing
February 2019
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The MCM8/9 complex: A recent recruit to the roster of helicases involved in genome maintenance.

DNA Repair (Amst) 2019 04 5;76:1-10. Epub 2019 Feb 5.

Department of Chemistry and Biochemistry, Baylor University, Waco, Texas, 76798, USA. Electronic address:

There are several DNA helicases involved in seemingly overlapping aspects of homologous and homoeologous recombination. Mutations of many of these helicases are directly implicated in genetic diseases including cancer, rapid aging, and infertility. MCM8/9 are recent additions to the catalog of helicases involved in recombination, and so far, the evidence is sparse, making assignment of function difficult. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15687864183031
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http://dx.doi.org/10.1016/j.dnarep.2019.02.003DOI Listing
April 2019
2 Reads

A hypothesis: Could telomere length and/or epigenetic alterations contribute to infertility in females with Turner syndrome?

Am J Med Genet C Semin Med Genet 2019 Mar 11;181(1):108-116. Epub 2019 Feb 11.

Department of Pathology, Virginia Commonwealth University, Richmond, Virginia.

One of the traits most consistently seen in females with Turner syndrome is premature ovarian insufficiency (POI). The biological mechanisms underlying the germ cell atresia that leads to infertility in most women with Turner syndrome are unclear. Given that telomeres are important for proper chromosomal pairing and other early steps in meiosis and oogenesis, one can conjecture that perturbations in telomere length and/or function might contribute to the POI associated with Turner syndrome. Read More

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http://dx.doi.org/10.1002/ajmg.c.31684DOI Listing
March 2019
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Overnight ovarian tissue transportation for centralized cryobanking: a feasible option.

Reprod Biomed Online 2019 Jan 19. Epub 2019 Jan 19.

University Women's Hospital Bern, Division of Gynecological Endocrinology and Reproductive Medicine, Effingerstrasse 102, Bern 3010, Switzerland.

Research Question: Is overnight transportation of ovarian tissue before cryopreservation in a centralized cryobank from the FertiPROTEKT network feasible?

Design: Data from 1810 women with cryopreserved ovarian tissue after overnight transportation from December 2000 to December 2017 were analysed with a focus on transportation, tissue activity parameters and pregnancy, and delivery rates after transplantation.

Results: A total of 92.4% of tissue samples arrived at ideal temperatures of 2-8°C, 0. Read More

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http://dx.doi.org/10.1016/j.rbmo.2019.01.006DOI Listing
January 2019
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Inflamm-Aging: A New Mechanism Affecting Premature Ovarian Insufficiency.

J Immunol Res 2019 2;2019:8069898. Epub 2019 Jan 2.

Jiangxi Medical College, Nanchang University, Nanchang, China.

The normal function of ovaries, along with the secretion of sex hormones, is among the most important endocrine factors that maintain the female sexual characteristics and promote follicular development and ovulation. Premature ovarian insufficiency (POI) is a common cause in the etiology of female infertility. It is defined as the loss of ovarian function before the age of 40. Read More

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http://dx.doi.org/10.1155/2019/8069898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334348PMC
January 2019
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The ability of an LC-MS/MS-based erythrocyte GALT enzyme assay to predict the phenotype in subjects with GALT deficiency.

Mol Genet Metab 2019 Jan 22. Epub 2019 Jan 22.

Manton Center for Orphan Disease Research, Division of Genetics and Genomics, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:

Background: GALT deficiency is a rare genetic disorder of carbohydrate metabolism. Due to the decreased activity or absence of the enzyme galactose-1-phosphate uridylyltransferase (GALT), cells from affected individuals are unable to metabolize galactose normally. Lactose consumption in the newborn period could potentially lead to a lethal disease process with multi-organ involvement. Read More

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http://dx.doi.org/10.1016/j.ymgme.2019.01.016DOI Listing
January 2019
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Ovarian function after allogeneic hematopoietic stem cell transplantation in children and young adults given 8-Gy total body irradiation-based reduced-toxicity myeloablative conditioning.

Pediatr Transplant 2019 Feb 3:e13372. Epub 2019 Feb 3.

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.

Background: The spectrum of late sequelae after hematopoietic stem cell transplantation (HSCT) includes infertility, which is the most frequent complication. Some reports suggested that ovarian function may be better preserved in females undergoing HSCT with reduced-intensity conditioning (RIC) than with conventional myeloablative conditioning (MAC). However, the impact of HSCT after 8-Gy TBI-based reduced-toxicity MAC (RTMAC), whose efficacy is between those of conventional MAC and RIC, on ovarian function remains unclear. Read More

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http://dx.doi.org/10.1111/petr.13372DOI Listing
February 2019
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Does theFMR1 gene affect IVF success?

Reprod Biomed Online 2019 Apr 10;38(4):560-569. Epub 2018 Dec 10.

AdvaGenix, Rockville MD, USA.

FMR1 CGG trinucleotide repeat expansions are associated with Fragile X syndrome (full mutations) and primary ovarian insufficiency (premutation range); the effect of FMR1 on the success of fertility treatment is unclear. The effect of FMR1 CGG repeat lengths on IVF outcomes after ovarian stimulation was reviewed. PubMed was searched for studies on IVF-related outcomes reported by FMR1 trinucleotide repeat length published between 2002 and December 2017. Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.11.009DOI Listing
April 2019
6 Reads

Increased risk of incident chronic medical conditions in infertile women: analysis of US claims data.

Am J Obstet Gynecol 2019 Jan 30. Epub 2019 Jan 30.

Department of Urology, Stanford University School of Medicine, Stanford, CA.

Background: The risk of common chronic medical conditions among infertile women is not known.

Objective: The objective of the study was to study the association between female infertility and the risk of incident chronic disease.

Study Design: This was a retrospective cohort analysis using the Optum deidentified Clinformatics Datamart from 2003 through 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029378193024
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http://dx.doi.org/10.1016/j.ajog.2019.01.214DOI Listing
January 2019
6 Reads

The first report showing de novo partial 21q monosomy in an adult woman with occult primary ovarian insufficiency (POI).

Clin Chem Lab Med 2019 Feb 4. Epub 2019 Feb 4.

Center for Molecular Diagnosis of Genetic Diseases, Dongfang Hospital, Xiamen University Medical College, 156 Xi'erhuanbei Road, Fuzhou City, Fujian Province 350025, P.R. China, Phone/Fax: +8659183721105.

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http://dx.doi.org/10.1515/cclm-2018-1271DOI Listing
February 2019
2 Reads