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    Radiation-associated breast cancer and gonadal hormone exposure: a report from the Childhood Cancer Survivor Study.
    Br J Cancer 2017 Jun 20. Epub 2017 Jun 20.
    Division of Medical Oncology, Departments of Medicine and Community and Family Medicine, Duke University Medical Center, Durham, NC 27705, USA.
    Background: The relationship between hormone exposure and breast cancer risk in women treated with chest radiotherapy for childhood cancer is uncertain.

    Methods: Participants included 1108 females from the Childhood Cancer Survivor Study who were diagnosed with childhood cancer 1970-1986, treated with chest radiotherapy, and survived to ages ⩾20 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) from Cox models adjusted for chest radiation field, delivered dose, anthracycline exposure, and age at childhood cancer estimated risk. Read More

    Impact of vitamin D levels on ovarian reserve and ovarian response to ovarian stimulation in oocyte donors.
    Reprod Biomed Online 2017 May 19. Epub 2017 May 19.
    IVI Madrid, Rey Juan Carlos University, Madrid 28023, Spain.
    Recently, growing interest in vitamin D has emerged from findings that demonstrate a low vitamin D status in populations. Similarly, much interest has been shown in the role that anti-Müllerian hormone (AMH) plays in reproductive physiology. Considerable confusion as to whether vitamin D status is related to ovarian function can be found in the literature. Read More

    Clinical follow-up of the first SF-1 insufficient female patient.
    Ann Endocrinol (Paris) 2017 Jun 14. Epub 2017 Jun 14.
    Department of Endocrinology and Diabetology University Children's Hospital, Zurich, Switzerland.
    Objective: Steroidogenic factor 1 (SF-1/NR5A1) plays a crucial role in regulating adrenal development, gonad determination and differentiation, and in the hypothalamic-pituitary control of reproduction and metabolism. In men (46, XY), it is known that mutations in SF-1/NR5A1 gene cause a wide phenotypic spectrum with variable degrees of undervirilization. In recent years, the role of SF-1 in the ovarian function was increasingly discussed and alterations in the gene were related to primary ovarian insufficiency. Read More

    Successful pregnancy with donor eggs in-vitro fertilization after premature ovarian insufficiency in a tertiary hospital in a low-income setting: a case report.
    Fertil Res Pract 2016 21;2:12. Epub 2016 Nov 21.
    Clinique de l'Aeroport, Douala, Cameroon.
    Background: Premature Ovarian Insufficiency (POI) is classically defined as 4-6 months of cessation of menses (amenorrhea) in women under 40, associated with menopausal level of serum gonadotropins FSH > 40 IU/L and hypo-estrogenism and is also referred to as hypergonadotropic hypogonadism. This disorder can manifest as primary amenorrhea without the onset of menses (menarche), or as secondary amenorrhea after menarche and pubertal development. The diagnosis of this condition in Cameroon is sometimes difficult because of the high cost of hormonal assays and the few laboratories offering these services. Read More

    Anti-Mullerian Hormone (AMH) Determinations in the Pediatric and Adolescent Endocrine Practice.
    Pediatr Endocrinol Rev 2017 Jun;14(4):364-370
    Reproductive Endocrinology and Genetics Unit, IVF Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Hebrew University School of Medicine, PO Box 3235, Jerusalem 9103102, Israel.
    Anti-Mullerian hormone (AMH), secreted by immature testicular Sertoli-cells, triggers the regression of male fetal Mullerian ducts. During puberty, AMH is downregulated by intratesticular testosterone. In females, AMH is secreted from granulosa cells of immature ovarian follicles from late prenatal life until menopause; serum concentration is 5-20 times lower in females than in males through lifetime. Read More

    Premature ovarian insufficiency in general practice: Meeting the needs of women.
    Aust Fam Physician 2017 Jun;46(6):360-366
    Background: Premature ovarian insufficiency (POI), defined as amenorrhoea due to the loss of ovarian function before 40 years of age, can occur spontaneously or be secondary to medical therapies. POI is associated with cardiovascular morbidity, osteoporosis and premature mortality. Women with POI present in primary care with menstrual disturbance, menopausal symptoms, infertility and, often, significant psychosocial issues. Read More

    Association of miR-938G>A Polymorphisms with Primary Ovarian Insufficiency (POI)-Related Gene Expression.
    Int J Mol Sci 2017 Jun 12;18(6). Epub 2017 Jun 12.
    Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Korea.
    MicroRNAs (miRNAs) post-transcriptionally regulate gene expression in animals and plants. The aim of this study was to investigate whether polymorphisms in miR-938 are associated with the risk of primary ovarian insufficiency (POI) and POI-related target gene regulation. We identified the miR-938G>A polymorphisms within the seed sequence of mature miRNA and aligned the seed sequence with the 3' untranslated region (UTR) of the gonadotropin-releasing hormone receptor (GnRHR) mRNA, a miR-938 target gene. Read More

    Non-genomic actions of 17-β estradiol restore respiratory neuroplasticity in young ovariectomized female rats.
    J Neurosci 2017 Jun 7. Epub 2017 Jun 7.
    University of Wisconsin-Madison, School of Veterinary Medicine, Department of Comparative Biosciences, 2015 Linden Dr., Madison, WI, USA, 53706
    Gonadal steroids modulate CNS plasticity, including phrenic long-term facilitation (pLTF), a form of spinal respiratory neuroplasticity resulting in increased phrenic nerve motor output following exposure to acute intermittent hypoxia (aIH; three 5 min episodes, 10.5% O2). Despite the importance of respiratory system neuroplasticity, and its dependence on estrogen in males, little is known about pLTF expression or mechanisms of estrogen signaling in females. Read More

    Fertility in adult women with classic galactosemia and primary ovarian insufficiency.
    Fertil Steril 2017 Jun 1. Epub 2017 Jun 1.
    Department of Pediatrics and Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands. Electronic address:
    Objective: To study pregnancy chance in adult women with classic galactosemia and primary ovarian insufficiency. Despite dietary treatment, >90% of women with classic galactosemia develop primary ovarian insufficiency, resulting in impaired fertility. For many years, chance of spontaneous conception has not been considered, leading to counseling for infertility. Read More

    Exosomes derived from human umbilical cord mesenchymal stem cells protect against cisplatin-induced ovarian granulosa cell stress and apoptosis in vitro.
    Sci Rep 2017 May 31;7(1):2552. Epub 2017 May 31.
    Department of obstetrics and gynecology, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan, 250012, Shandong Province, P.R. China.
    Human umbilical cord mesenchymal stem cells (huMSCs) can treat primary ovarian insufficiency (POI) related to ovarian granulosa cell (OGC) apoptosis caused by cisplatin chemotherapy. Exosomes are a class of membranous vesicles with diameters of 30-200 nm that are constitutively released by eukaryotic cells. Exosomes mediate local cell-to-cell communication by transferring microRNAs and proteins. Read More

    Evaluation of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Red Blood Cell Distribution Width-Platelet Ratio for Diagnosis of Premature Ovarian Insufficiency.
    J Family Reprod Health 2016 Dec;10(4):211-216
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Adnan Menderes University, Aydın, Turkey.
    Objective: To evaluate whether systemic inflammatory markers (neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and red blood cell distribution width (RDW) to platelet ratio (RPR)) can be used as reliable markers for the diagnosis of premature ovarian insufficiency (POI) and to determine if there is a relationship between these markers and follicle stimulating hormone (FSH), Anti-Müllerian Hormone (AMH) levels. Materials and methods: Written and electronic medical records were reviewed using searches for diagnoses with the terms of 'premature ovarian failure', 'premature ovarian insufficiency'. Patients younger than the age of 40 were diagnosed to have premature ovarian insufficiency based on their menstrual history and sonographic examination and they were compared with healthy females. Read More

    A homozygous donor splice-site mutation in the meiotic gene MSH4 causes primary ovarian insufficiency.
    Hum Mol Genet 2017 May 24. Epub 2017 May 24.
    Center For Research in Genetics and Genomics-CIGGUR. GENIUROS Research Group. School of Medicine and Health Sciences. Universidad del Rosario. Bogotá, Colombia.
    Premature ovarian insufficiency (POI) is a frequent pathology that affects women under 40 years of age, characterized by an early cessation of menses and high FSH levels. Despite recent progresses in molecular diagnosis, the etiology of POI remains idiopathic in most cases. Whole-exome sequencing of members of a Colombian family affected by POI allowed us to identify a novel homozygous donor splice-site mutation in the meiotic gene MSH4 (MutS Homolog 4). Read More

    New mutations in non-syndromic primary ovarian insufficiency patients identified via whole-exome sequencing.
    Hum Reprod 2017 May 13:1-9. Epub 2017 May 13.
    Center For Research in Genetics and Genomics (CIGGUR), GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24N° 63C-69, CP 112111, Bogotá DC, Colombia.
    Study Question: Is it possible to identify new mutations potentially associated with non-syndromic primary ovarian insufficiency (POI) via whole-exome sequencing (WES)?

    Summary Answer: WES is an efficient tool to study genetic causes of POI as we have identified new mutations, some of which lead to protein destablization potentially contributing to the disease etiology.

    What Is Known Already: POI is a frequently occurring complex pathology leading to infertility. Mutations in only few candidate genes, mainly identified by Sanger sequencing, have been definitively related to the pathogenesis of the disease. Read More

    Premature Ovarian Insufficiency: An Adolescent Series.
    J Pediatr Adolesc Gynecol 2017 May 11. Epub 2017 May 11.
    1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece. Electronic address:
    Study Objective: To study the presentation and causes of premature ovarian insufficiency (POI) in adolescents.

    Design: Retrospective notes review.

    Setting: Tertiary referral outpatient clinic for pediatric and adolescent gynecology. Read More

    Combined pituitary hormone deficiency in a girl with 48, XXXX and Rathke's cleft cyst.
    Hormones (Athens) 2017 Jan;16(1):92-98
    Section on Endocrinology and Genetics, NICHD, National Institutes of Health, Pediatric endocrinology training program, NICHD, National Institutes of Health, Bethesda, MD, USA.
    Background: Tetrasomy X is a rare chromosomal aneuploidy seen in girls, associated with facial dysmorphism, premature ovarian insufficiency and intellectual disability. A Rathke's cleft cyst (RCC) is a remnant of Rathke's pouch which may cause multiple pituitary hormone deficiencies by exerting pressure on the pituitary gland in the sella.

    Methods/results: The patient was diagnosed with tetrasomy X by karyotyping during infancy. Read More

    Cyclophosphamide and acrolein induced oxidative stress leading to deterioration of metaphase II mouse oocyte quality.
    Free Radic Biol Med 2017 May 9;110:11-18. Epub 2017 May 9.
    Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA. Electronic address:
    Cyclophosphamide (CTX) is a chemotherapeutic agent widely used to treat ovarian, breast, and hematological cancers as well as autoimmune disorders. Such chemotherapy is associated with reproductive failure and premature ovarian insufficiency. The mechanism by which CTX and/or its main metabolite, acrolein, affect female fertility remains unclear, but it is thought to be caused by an overproduction of reactive oxygen species (ROS). Read More

    Role of microRNAs in premature ovarian insufficiency.
    Reprod Biol Endocrinol 2017 May 12;15(1):38. Epub 2017 May 12.
    The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200030, China.
    Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follicle-stimulating hormone (FSH) in women <40-year-old, primarily originating from iatrogenic factors, karyotypic abnormalities, and genetic factors. However, the etiology of POI remains unknown in approximately 90% of cases. Read More

    Controlled ovarian stimulation and IVF pregnancy in a trisomy X carrier with associated hypogonadotropic hypogonadism.
    Gynecol Endocrinol 2017 May 9:1-3. Epub 2017 May 9.
    a Department of Neurosciences , Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa , Genoa , Italy.
    We describe successful controlled ovarian stimulation (COS) and the first known IVF pregnancy in a trisomy X carrier with associated hypogonadotropic hypogonadism (HH) linked to a chromosome 4 double mutation in the allele of the Gonadotropins Releasing Hormone receptor (GnRHr) gene. Previous administration of low dose of gonadotropins, as recommended in patients with HH, led to poor follicular recruitment. Since trisomy X is a risk factor for diminished ovarian reserve (DOR) and premature ovarian insufficiency (POI), higher doses of gonadotropins led to better ovarian response. Read More

    The ovarian response in fragile X patients and premutation carriers undergoing IVF-PGD: reappraisal.
    Hum Reprod 2017 May 3:1-4. Epub 2017 May 3.
    Racine IVF Unit, Genetic Institute, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Study Question: What is the association between the ovarian response and the number of CGG repeats among full mutation and premutation carriers of fragile X (FMR1), undergoing controlled ovarian hyperstimulation (COH) for PGD?

    Summary Answer: Ovarian response was normal in full mutation patients but decreased in premutation carriers, although the number of repeats was not statistically significantly associated with the number of oocytes retrieved.

    What Is Known Already: There is inconsistent data in the literature regarding ovarian response in FMR1 carriers. Studies exploring the ovarian response of full mutation patients are lacking. Read More

    Melatonin protects premature ovarian insufficiency induced by tripterygium glycosides: role of SIRT1.
    Am J Transl Res 2017 15;9(4):1580-1602. Epub 2017 Apr 15.
    Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011, China.
    Melatonin confers protective effects on premature ovarian insufficiency (POI) induced by tripterygium glycosides (TG) by reducing oxidative stress. Silent information regulator 1 (SIRT1) signaling is found to be associated with the physiology and pathology of ovary. We hypothesize that melatonin could protect POI via activating SIRT1 signaling. Read More

    Prospective evaluation of serum anti-Müllerian hormone dynamics in 250 women of reproductive age treated with chemotherapy for breast cancer.
    Eur J Cancer 2017 Jul 29;79:72-80. Epub 2017 Apr 29.
    Service de médecine et biologie du développement et de la reproduction, CHU de Nantes, Nantes, France; INSERM UMR 1064 - ITUN, Nantes, France; Faculté de médecine, Université de Nantes, Nantes, France. Electronic address:
    Aim: Women of reproductive age with breast cancer generally receive gonadotoxic chemotherapy. Fertility issues are of great concern for them. However, little is known on ovarian damage during chemotherapy and its evolution during long-term follow-up. Read More

    Association of skewed X-chromosome inactivation with FMR1 CGG repeat length and anti-Mullerian hormone levels: a cohort study.
    Reprod Biol Endocrinol 2017 Apr 28;15(1):34. Epub 2017 Apr 28.
    The Center for Human Reproduction (CHR), New York, NY, USA.
    Background: Premutation range CGGn repeats of the FMR1 gene denote risk toward primary ovarian insufficiency (POI), also called premature ovarian failure (POF). This prospective cohort study was undertaken to determine if X-chromosome inactivation skew (sXCI) is associated with variations in FMR1 CGG repeat length and, if so, is also associated with age adjusted antimüllerian hormone (AMH) levels as an indicator of functional ovarian reserve (FOR).

    Methods: DNA samples of 58 women were analyzed for methylation status and confirmation of CGGn repeat length. Read More

    Primary ovarian insufficiency with t(5;13): a case report and literature review on disrupted genes.
    Climacteric 2017 Apr 28:1-5. Epub 2017 Apr 28.
    b Reproductive Biotechnology Research Center , Avicenna Research Institute, ACECR , Tehran , Iran.
    Objectives: To report a woman with primary ovarian insufficiency (POI) with reciprocal translocation between chromosomes 5 and 13.

    Methods: Chromosomal analysis (G-banding) of a 39-year-old woman with elevated gonadotropin levels and secondary amenorrhea and review of the literature with a special focus on disrupted genes at the reported breakpoints.

    Results: A reciprocal translocation between the long arms of chromosomes 5 and 13 was identified in the patient (46,XX,t(5;13)(q13;q14)). Read More

    Hormone supplementation for pubertal induction in girls.
    Arch Dis Child 2017 Apr 26. Epub 2017 Apr 26.
    Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK.
    Pubertal induction in girls with ovarian insufficiency aims to mimic normal puberty, a highly complex process. Here we amalgamate the sparse global evidence and propose three options for pubertal induction regimens including oral ethinyloestradiol, and oral and transdermal 17β-oestradiol. The introduction of progestogens is discussed and the transition to hormone supplementation for adult women. Read More

    Characterization of FOXO1, 3 and 4 transcription factors in ovaries of fetal, prepubertal and adult rhesus macaques.
    Biol Reprod 2017 Apr 22. Epub 2017 Apr 22.
    Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, 97006, USA.
    The phosphoinositide 3-kinase/AKT signaling pathway negatively regulates follicle activation via the forkhead box O (FOXO) transcription factor in rodents. FOXO3 knockout mice exhibit global activation of primordial follicles leading to early depletion of ovarian follicles and subsequent infertility. Whether a similar mechanism for follicle activation exists in the primate ovary is unclear. Read More

    Age-independent anti-Müllerian hormone (AMH) standard deviation scores to estimate ovarian function.
    Eur J Obstet Gynecol Reprod Biol 2017 Jun 18;213:64-70. Epub 2017 Apr 18.
    Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry University, Hospital RWTH Aachen, 51072 Aachen, Germany.
    Objectivies: To determine single year age-specific anti-Müllerian hormone (AMH) standard deviation scores (SDS) for women associated to normal ovarian function and different ovarian disorders resulting in sub- or infertility.

    Design And Methods: Determination of particular year median and mean AMH values with standard deviations (SD), calculation of age-independent cut off SDS for the discrimination between normal ovarian function and ovarian disorders.

    Results: Single-year-specific median, mean, and SD values have been evaluated for the Beckman Access AMH immunoassay. Read More

    Committee Opinion No. 698: Hormone Therapy in Primary Ovarian Insufficiency.
    • Authors:
    Obstet Gynecol 2017 05;129(5):e134-e141
    Primary ovarian insufficiency describes a spectrum of declining ovarian function and reduced fecundity due to a premature decrease in initial follicle number, an increase in follicle destruction, or poor follicular response to gonadotropins. The sequelae of primary ovarian insufficiency include vasomotor symptoms, urogenital atrophy, osteoporosis and fracture, cardiovascular disease, and increased all-cause mortality. In women with primary ovarian insufficiency, systemic hormone therapy (HT) is an effective approach to treat the symptoms of hypoestrogenism and mitigate long-term health risks if there are no contraindications to treatment. Read More

    Committee Opinion No. 698 Summary: Hormone Therapy in Primary Ovarian Insufficiency.
    • Authors:
    Obstet Gynecol 2017 May;129(5):963-964
    Primary ovarian insufficiency describes a spectrum of declining ovarian function and reduced fecundity due to a premature decrease in initial follicle number, an increase in follicle destruction, or poor follicular response to gonadotropins. The sequelae of primary ovarian insufficiency include vasomotor symptoms, urogenital atrophy, osteoporosis and fracture, cardiovascular disease, and increased all-cause mortality. In women with primary ovarian insufficiency, systemic hormone therapy (HT) is an effective approach to treat the symptoms of hypoestrogenism and mitigate long-term health risks if there are no contraindications to treatment. Read More

    Hormone therapy for premature ovarian insufficiency patients with malignant hematologic diseases.
    Climacteric 2017 Jun 11;20(3):268-273. Epub 2017 Apr 11.
    d Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Peking University Institute of Hematology, People's Hospital , Beijing , China.
    Objectives: The current usage of hormone therapy (HT) among perimenopausal women is low in China, especial in women with premature ovarian insufficiency (POI) with malignant hematologic diseases. This study investigated the efficacy and safety of HT in POI patients with malignant hematologic diseases who have received myeloablative chemotherapy and hemopoietic stem cell transplantation (HSCT).

    Methods: Patients who had POI after myeloablative chemotherapy and HSCT for malignant hematologic diseases were enrolled. Read More

    Fertility preservation in women with CNS tumors.
    Expert Rev Anticancer Ther 2017 May 17;17(5):439-445. Epub 2017 Apr 17.
    a Medical Oncology Department , AUSL-IRCCS Scienze Neurologiche , Bologna , Italy.
    Introduction: Fertility impairment due to treatments is a major concern for adolescents and young adult patients who survived cancer. Areas covered: Chemotherapy may determine a detrimental effect on ovary function, leading to infertility, and premature ovarian failure. Embryo and oocyte cryopreservation is a standard strategy for fertility preservation; other strategies, such as gonadal tissue cryopreservation and the use of gonadotropin - releasing hormone agonist, are still considered experimental. Read More

    Whole-exome sequencing identifies a homozygous donor splice site mutation in STAG3 that causes primary ovarian insufficiency.
    Clin Genet 2017 Apr 10. Epub 2017 Apr 10.
    Institute of Reproduction and Stem Cell Engineering, Central South University, Changsha, Hunan, 410078, People's Republic of China.
    Primary ovarian insufficiency (POI) is the depletion or loss of normal ovarian function, which cause infertility in women before the age of 40 years. Two homozygous germline truncation mutations in STAG3 gene had been reported to causes POI in consanguineous families. Here, we aimed to identify the genetic cause of POI in two affected sisters manifested with primary amenorrhea and partial development of secondary sexual characters with normal range of height of a consanguineous Han Chinese family. Read More

    Determinants of percent mammographic density in women with premature ovarian insufficiency.
    Climacteric 2017 Jun 9;20(3):280-284. Epub 2017 Apr 9.
    a Department of Obstetrics and Gynecology, School of Medical Sciences , University of Campinas , São Paulo , Brazil.
    Objective: To evaluate the determinants of breast density in women with premature ovarian insufficiency (POI).

    Methods: In a cross-sectional study of 163 women with POI undergoing mammography, percent mammographic density (PMD) was evaluated by digitizing the image. PMD was correlated with age, age at menarche, age at POI, time since POI, body mass index (BMI), gestational history and hormone therapy (HT) use (duration, dose, regimen). Read More

    Oocyte stem cells: fact or fantasy?
    Reproduction 2017 Jul 7;154(1):R23-R35. Epub 2017 Apr 7.
    Nuffield Department of Obstetrics and GynaecologyUniversity of Oxford, Women's Centre, John Radcliffe Hospital, Oxford, United Kingdom
    For many decades, the dogma prevailed that female mammals had a finite pool of oocytes at birth and this was gradually exhausted during a lifetime of reproductive function. However, in 2004, a new era began in the field of female oogenesis. A study was published that appeared to detect oocyte-stem cells capable of generating new eggs within mouse ovaries. Read More

    Environmental pollutants, a possible etiology for premature ovarian insufficiency: a narrative review of animal and human data.
    Environ Health 2017 Apr 7;16(1):37. Epub 2017 Apr 7.
    Médecine de la Reproduction, CHU de Toulouse, Hôpital Paule de Viguier, 330 avenue de Grande Bretagne, F-31059, Toulouse Cedex, France.
    Background: Because only 25% of cases of premature ovarian insufficiency (POI) have a known etiology, the aim of this review was to summarize the associations and mechanisms of the impact of the environment on this pathology. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included ovary, follicle, oocyte, endocrine disruptor, environmental exposure, occupational exposure, environmental contaminant, pesticide, polyaromatic hydrocarbon, polychlorinated biphenyl PCB, phenol, bisphenol, flame retardant, phthalate, dioxin, phytoestrogen, tobacco, smoke, cigarette, cosmetic, xenobiotic. Read More

    Sensitivity and specificity of clinical findings for the diagnosis of pelvic congestion syndrome in women with chronic pelvic pain.
    Phlebology 2017 Jan 1:268355517702057. Epub 2017 Jan 1.
    2 Grupo de Investigación Salud Comfamiliar, Pereira, Colombia.
    Background Pelvic congestion syndrome is among the causes of pelvic pain. One of the diagnostic tools is pelvic venography using Beard's criteria, which are 91% sensitive and 80% specific for this syndrome. Objective To assess the diagnostic performance of the clinical findings in women diagnosed with pelvic congestion syndrome coming to a Level III institution. Read More

    Review of clinical indicators, including serum anti-Müllerian hormone levels, for identification of women who should consider egg freezing.
    Int J Gynaecol Obstet 2017 Jul 28;138(1):37-41. Epub 2017 Apr 28.
    Merrion Fertility Clinic, Dublin, Ireland.
    Objective: To identify women, on the basis of clinical history and serum anti-Müllerian hormone (AMH) levels, who are at risk of premature ovarian insufficiency and thereby guide appropriate early referral for egg freezing.

    Methods: In a retrospective study, data were reviewed from women attending two fertility clinics in Dublin, Ireland, between August 2011 and December 2012. Case histories of women aged 35 years or younger were assessed to identify risk factors for reduced ovarian reserve, including endometriosis, ovarian surgery, and family history of premature ovarian failure (POF). Read More

    Use of Hormone Replacement in Females with Endocrine Disorders.
    Horm Res Paediatr 2017 Apr 4;87(4):215-223. Epub 2017 Apr 4.
    Hormone replacement therapy (HRT) is necessary in adolescents with primary ovarian insufficiency (POI) in order to avoid estrogen deficiency. The goal of this minirewiew is to present the different types of estrogens (17β-estradiol, estradiol valerate, ethinyl estradiol, and combined equine estrogens) as well as the different types of progestins available. In order to choose among the different types of HRTs, the features of each regimen are being discussed as well as their risks and their respective benefits. Read More

    Premature Ovarian Insufficiency: Phenotypic Characterization within Different Etiologies.
    J Clin Endocrinol Metab 2017 Mar 28. Epub 2017 Mar 28.
    Center for Reproductive Medicine, Shandong University. National Research Center for Assisted Reproductive Technology and Reproductive Genetics, China. The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.
    Context: Premature ovarian insufficiency (POI) is highly heterogeneous, both in phenotype and etiology. They are not yet clearly stated and correlated.

    Objective: To characterize clinical presentations of a large, well-phenotyped cohort of women with POI, and correlate phenotypes with etiologies to draw a comprehensive clinical picture of POI. Read More

    Premature Ovarian Insufficiency in Childhood Cancer Survivors: A Report from the St. Jude Lifetime Cohort.
    J Clin Endocrinol Metab 2017 Mar 24. Epub 2017 Mar 24.
    Memorial Sloan Kettering Cancer Center, New York NY, USA-Department of Pediatrics.
    Context: Long-term follow-up data on premature ovarian insufficiency (POI) in childhood cancer survivors are limited.

    Context: To describe the prevalence of POI, its risk factors and associated long-term adverse health outcomes.

    Design: Cross-sectional. Read More

    Recent advances in the field of ovarian tissue cryopreservation and opportunities for research.
    J Assist Reprod Genet 2017 Jun 1;34(6):709-722. Epub 2017 Apr 1.
    Howard W. and Georgeanna Seegar Jones Division of Reproductive Sciences and Women's Health Research, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross Building (Room 624), Baltimore, MD, 21205, USA.
    Purpose: The purpose of this study was to summarize the latest advances and successes in the field of ovarian tissue cryopreservation while identifying gaps in current knowledge that suggest opportunities for future research.

    Methods: A systematic review was performed according to PRISMA guidelines for all relevant full-text articles in PubMed published in English that reviewed or studied historical or current advancements in ovarian tissue cryopreservation and auto-transplantation techniques.

    Results: Ovarian tissue auto-transplantation in post-pubertal women is capable of restoring fertility with over 80 live births currently reported with a corresponding pregnancy rate of 23 to 37%. Read More

    BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9.
    J Clin Endocrinol Metab 2017 Mar;102(3):1009-1019
    Department of Physiology, Monash University, Clayton, Victoria 3800, Australia.
    Context: Bone morphogenetic protein (BMP)15 is an oocyte-specific growth factor, which, together with growth differentiation factor (GDF) 9, regulates folliculogenesis and ovulation rate. Multiple mutations in BMP15 have been identified in women with primary ovarian insufficiency (POI), supporting a pathogenic role; however, the underlying biological mechanism of many of these mutants remains unresolved.

    Objectives: To determine how mutations associated with ovarian dysfunction alter the biological activity of human BMP15. Read More

    Polycystic ovarian syndrome and the risk of subsequent primary ovarian insufficiency: a nationwide population-based study.
    Menopause 2017 Mar 27. Epub 2017 Mar 27.
    1Institute of Information Science, Academia Sinica, Taipei, Taiwan 2Department of Physical Medicine and Rehabilitation, Mackay Memorial Hospital, Taipei, Taiwan 3Department of Mechanical Engineering, National Chiao-Tung University, Hsinchu, Taiwan 4Department of Obstetrics and Gynecology, Taipei Tzu-Chi Hospital, The Buddhist Tzu-Chi Medical Foundation, Taipei, Taiwan 5School of Medicine, Tzu-Chi University, Hualien, Taiwan.
    Objective: To evaluate the risk of subsequent primary ovarian insufficiency (POI) amongst patients with a history of polycystic ovarian syndrome (PCOS).

    Methods: This nationwide, population-based study is an inspection and review of data from the 1998 to 2012 Taiwan National Health Insurance Research Database. In a sample of 1,000,000 randomly sampled individuals, women with PCOS (exposure group; n = 7,049) and women without PCOS (contrast group; n = 70,490) were compared. Read More

    Galactose and its Metabolites Deteriorate Metaphase II Mouse Oocyte Quality and Subsequent Embryo Development by Disrupting the Spindle Structure.
    Sci Rep 2017 Mar 22;7(1):231. Epub 2017 Mar 22.
    Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
    Premature ovarian insufficiency (POI) is a frequent long-term complication of classic galactosemia. The majority of women with this disorder develop POI, however rare spontaneous pregnancies have been reported. Here, we evaluate the effect of D-galactose and its metabolites, galactitol and galactose 1-phosphate, on oocyte quality as well as embryo development to elucidate the mechanism through which these compounds mediate oocyte deterioration. Read More

    A potential functional association between mutant BMPR2 and primary ovarian insufficiency.
    Syst Biol Reprod Med 2017 Jun 17;63(3):145-149. Epub 2017 Mar 17.
    a Centro de Investigación en Genética y Genómica-CIGGUR, Grupo GENIUROS, Escuela de Medicina y Ciencias de la Salud , Universidad del Rosario , Bogotá , Colombia.
    Primary ovarian insufficiency (POI) affects ~1% of women in the general population. Despite numerous attempts at identifying POI genetic aetiology, coding mutations in only a few genes have been functionally related to POI pathogenesis. It has been suggested that mutant BMPR2 might contribute towards the phenotype. Read More

    Spontaneous Regression of Uterine Arteriovenous Malformations with Conservative Management.
    Case Rep Obstet Gynecol 2017 16;2017:6437670. Epub 2017 Feb 16.
    Department of Obstetrics and Gynecology, Graduate School of Medical Science, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan.
    Uterine arteriovenous malformation (AVM) can cause massive hemorrhage and is often treated with uterine artery embolization (UAE), which may lead to ovarian insufficiency. Thus, avoiding UAE should be considered, particularly in women undergoing fertility treatments. We present three women diagnosed with postmiscarriage AVM on color Doppler by transvaginal ultrasound imaging. Read More

    Learning and memory disabilities in IUGR babies: Functional and molecular analysis in a rat model.
    Brain Behav 2017 Mar 7;7(3):e00631. Epub 2017 Feb 7.
    Department of Pathology and Experimental Therapeutics School of Medicine University of Barcelona Barcelona Spain.
    Introduction: 1Intrauterine growth restriction (IUGR) is the failure of the fetus to achieve its inherent growth potential, and it has frequently been associated with neurodevelopmental problems in childhood. Neurological disorders are mostly associated with IUGR babies with an abnormally high cephalization index (CI) and a brain sparing effect. However, a similar correlation has never been demonstrated in an animal model. Read More

    Disorganization of the germ cell pool leads to primary ovarian insufficiency.
    Reproduction 2017 Jun 13;153(6):R205-R213. Epub 2017 Mar 13.
    Department of Advanced Reproductive MedicineSt. Marianna University School of Medicine, Kawasaki City, Kanagawa, Japan
    The mammalian ovary is an organ that controls female germ cell development, storing them and releasing mature oocytes for transporting to the oviduct. During the fetal stage, female germ cells change from a proliferative state to meiosis before forming follicles with the potential for the growth of surrounding somatic cells. Understanding of molecular and physiological bases of germ cell development in the fetal ovary contributed not only to the elucidation of genetic disorders in primary ovarian insufficiency (POI), but also to the advancement of novel treatments for patients with POI. Read More

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