5,003 results match your criteria Ovarian Insufficiency


Lipid Profile in Patients With Primary Ovarian Insufficiency: A Systematic Review and Meta-Analysis.

Front Endocrinol (Lausanne) 2022 10;13:876775. Epub 2022 Jun 10.

Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.

Backgrounds: A large number of studies have investigated the effect of early menopause on cardiovascular disease (CVD) outcomes and the relationship between the levels of lipid profile and primary ovarian insufficiency (POI). However, the results are inconsistent. The aim of this meta-analysis was to assess whether the levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) changed in women with POI relative to healthy controls. Read More

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Impact of abnormal karyotype on reproductive outcome in premature ovarian insufficiency.

Reprod Med Biol 2022 Jan-Dec;21(1):e12471. Epub 2022 Jun 15.

Advanced Reproductive Medicine Research Center International University of Health and Welfare School of Medicine Chiba Japan.

Purpose: This study evaluated the reproductive potential of premature ovarian insufficiency (POI) patients with abnormal karyotypes undergoing infertility treatments.

Methods: A retrospective analysis of infertility treatments in POI patients with an abnormal karyotype treatment. Clinical and laboratory data were analyzed. Read More

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Is premature ovarian insufficiency associated with mortality? A three-decade follow-up cohort.

Maturitas 2022 Jun 13;163:82-87. Epub 2022 Jun 13.

Quilín Clinic, Faculty of Medicine, University of Chile, Santiago de Chile, Chile.

Objective: To evaluate the association between premature ovarian insufficiency (POI) and mortality.

Materials And Methods: This was a secondary analysis of a long-term cohort of Chilean women who received preventive health care between 1990 and 1993. The exposure variable was POI and the outcome was death, and follow-up time was 30 years. Read More

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Association between thyroid autoimmunity and the decline of ovarian reserve in euthyroid women.

Reprod Biomed Online 2022 May 30. Epub 2022 May 30.

Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan Shandong 250012, China; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan Shandong 250012, China; Shandong Key Laboratory of Reproductive Medicine, Jinan Shandong 250012, China; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan Shandong 250012, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan Shandong 250012, China. Electronic address:

Research Question: Is thyroid autoimmunity (TAI) associated with the decline of ovarian reserve in euthyroid women?

Design: Case-control study. Data from 4302 euthyroid women with normal ovarian reserve (NOR) and low ovarian reserve (LOR), including biochemical premature ovarian insufficiency (POI) and overt POI, were retrospectively analysed. The prevalence and effect of TAI on ovarian reserve was evaluated between women with NOR and LOR. Read More

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Comparison of CD146 +/- mesenchymal stem cells in improving premature ovarian failure.

Stem Cell Res Ther 2022 Jun 21;13(1):267. Epub 2022 Jun 21.

Laboratory of Molecular Diagnosis and Regenerative Medicine, Medical Research Center, The Affiliate Hospital of Qingdao University, Qingdao, 266000, People's Republic of China.

Background: Mesenchymal stem cells (MSCs) are a heterogeneous group of subpopulations with differentially expressed surface markers. CD146 + MSCs correlate with high therapeutic and secretory potency. However, their therapeutic efficacy and mechanisms in premature ovarian failure (POF) have not been explored. Read More

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Both cis and trans-acting genetic factors drive somatic instability in female carriers of the FMR1 premutation.

Sci Rep 2022 Jun 21;12(1):10419. Epub 2022 Jun 21.

Department of Biochemistry and Molecular Medicine, University of California Davis, School of Medicine, Sacramento, CA, 95817, USA.

The fragile X mental retardation (FMR1) gene contains an expansion-prone CGG repeat within its 5' UTR. Alleles with 55-200 repeats are known as premutation (PM) alleles and confer risk for one or more of the FMR1 premutation (PM) disorders that include Fragile X-associated Tremor/Ataxia Syndrome (FXTAS), Fragile X-associated Primary Ovarian Insufficiency (FXPOI), and Fragile X-Associated Neuropsychiatric Disorders (FXAND). PM alleles expand on intergenerational transmission, with the children of PM mothers being at risk of inheriting alleles with > 200 CGG repeats (full mutation FM) alleles) and thus developing Fragile X Syndrome (FXS). Read More

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Primary ovarian insufficiency secondary to chemotherapy with inotuzumab ozogamicin and other agents.

J Assist Reprod Genet 2022 Jun 21. Epub 2022 Jun 21.

Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The University of Chicago, Chicago, IL, USA.

Recent advances in targeted therapy with monoclonal antibodies have significantly improved outcomes for people with cancer, sometimes allowing patients to avoid ovotoxic agents altogether. The current understanding is that monoclonal antibody cancer therapies that are not targeted to ovarian antigens should not impact ovarian reserve or increase the risk of primary ovarian insufficiency (POI). We present a case of rapid onset POI in a 23-year-old patient following chemotherapy for relapse/refractory B-cell acute lymphoblastic leukemia with a monoclonal antibody drug-conjugate, inotuzumab ozogamicin, that targets CD22. Read More

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Autism spectrum disorder in the fragile X premutation state: possible mechanisms and implications.

J Neurol 2022 Jun 20. Epub 2022 Jun 20.

Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis, 2825 50th Street, Sacramento, CA, 95817, USA.

There is increasing recognition of the heterogeneity of origin of cases of autism spectrum disorder (ASD) with multiple forms of ASD having been identified over the decades. Among these, a genetic etiology can be identified in 20-40% of cases when a full genetic work-up is completed. The Fragile X premutation state (characterized by the presence of 55-200 CGG repeats in the FMR1 gene) is a relatively newly identified disease state that has since been associated with several disorders including fragile X-associated tremor ataxia syndrome (FXTAS), fragile X-associated primary ovarian insufficiency (FXPOI) and most recently, fragile X-associated neurodevelopmental disorders (FXAND) which commonly includes anxiety and depression. Read More

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Human Ovarian Follicles Xenografted in Immunoisolating Capsules Survive Long Term Implantation in Mice.

Front Endocrinol (Lausanne) 2022 3;13:886678. Epub 2022 Jun 3.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States.

Female pediatric cancer survivors often develop Premature Ovarian Insufficiency (POI) owing to gonadotoxic effects of anticancer treatments. Here we investigate the use of a cell-based therapy consisting of human ovarian cortex encapsulated in a poly-ethylene glycol (PEG)-based hydrogel that replicates the physiological cyclic and pulsatile hormonal patterns of healthy reproductive-aged women. Human ovarian tissue from four donors was analyzed for follicle density, with averages ranging between 360 and 4414 follicles/mm. Read More

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Reproductive Health in Chronic Kidney Disease: The Implications of Sex and Gender.

Semin Nephrol 2022 Mar;42(2):142-152

Nephrologie, Centre Hospitalier Le Mans, Le Mans, France.

Chronic kidney disease (CKD) is frequently accompanied by reproductive health challenges in females and males alike. Progression of CKD is associated with escalating impairment of the hypothalamic-pituitary-gonadal axis, which facilitates evolving ovarian, testicular, and sexual dysfunction. Common clinical reproductive health complications in CKD include abnormal menstruation, impaired sexual health, and reduced fertility. Read More

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The Role of mA on Female Reproduction and Fertility: From Gonad Development to Ovarian Aging.

Front Cell Dev Biol 2022 30;10:884295. Epub 2022 May 30.

State Key Laboratory of Reproductive Medicine, Gusu School, Suzhou Municipal Hospital, Suzhou Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, China.

The growth and maturation of oocyte is accompanied by the accumulation of abundant RNAs and posttranscriptional regulation. N6-methyladenosine (mA) is the most prevalent epigenetic modification in mRNA, and precisely regulates the RNA metabolism as well as gene expression in diverse physiological processes. Recent studies showed that mA modification and regulators were essential for the process of ovarian development and its aberrant manifestation could result in ovarian aging. Read More

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Homozygous variant in KASH5 causes premature ovarian insufficiency by disordered meiotic homologous pairing.

J Clin Endocrinol Metab 2022 Jun 16. Epub 2022 Jun 16.

Center for Reproductive Medicine, Shandong University, Jinan, Shandong, 250012, China.

Context: Premature ovarian insufficiency (POI) affects 1%-3.7% of women at reproductive age, which etiology is heterogeneous. The LINC (linker of nucleoskeleton and cytoskeleton) complex, consisting of KASH5 and SUN1, plays an indispensable role in meiotic homolog pairing, determining the ovarian reserve. Read More

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Protective Effects of Antioxidants on Cyclophosphamide-Induced Ovarian Toxicity.

Biopreserv Biobank 2022 Jun 13. Epub 2022 Jun 13.

Nucleus of Biotechnology Applied to Ovarian Follicle Development, Department of Veterinary Medicine, Federal University of São Francisco Valley-UNIVASF, Petrolina, Brazil.

The most common limitation of anticancer chemotherapy is the injury to normal cells. Cyclophosphamide, which is one of the most widely used alkylating agents, can cause premature ovarian insufficiency and infertility since the ovarian follicles are extremely sensitive to their effects. Although little information is available about the pathogenic mechanism of cyclophosphamide-induced ovarian damage, its toxicity is attributed to oxidative stress, inflammation, and apoptosis. Read More

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Senotherapy Protects against Cisplatin-Induced Ovarian Injury by Removing Senescent Cells and Alleviating DNA Damage.

Oxid Med Cell Longev 2022 3;2022:9144644. Epub 2022 Jun 3.

Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

Ovarian damage induced by platinum-based chemotherapy seriously affects young women with cancer, manifesting as infertility, early menopause, and premature ovarian insufficiency. However, effective prevention strategies for such damage are lacking. Senescent cells may be induced by chemotherapeutic agents. Read More

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Ovarian reserve in premenopausal women with breast cancer.

Breast 2022 Aug 2;64:143-150. Epub 2022 Jun 2.

Department of Breast Surgery, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.

Background: As a special reproductive hormone and ovarian reserve indicator, the role of anti-Müllerian hormone (AMH) in premenopausal women with breast cancer deserves further study.

Methods: We conducted an in-depth analysis of the data from the EGOFACT study (NCT02518191), a phase Ⅲ, randomized, controlled trial involving premenopausal female breast cancer patients in two parallel groups: chemotherapy with or without gonadotropin-releasing hormone analogs (GnRHa). Three hundred thirty premenopausal women aged 25-49 years with operable stage I to III breast cancer were included in this study. Read More

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Impact of micronised progesterone and medroxyprogesterone acetate in combination with transdermal oestradiol on cardiovascular markers in women diagnosed with premature ovarian insufficiency or an early menopause: a randomised pilot trial.

Maturitas 2022 Jul 2;161:18-26. Epub 2022 Feb 2.

King's College Hospital NHS Foundation Trust, Department of Obstetrics and Gynaecology, Denmark Hill, Brixton, London SE5 9RS.

Objective: To compare the difference between micronised progesterone (MP) and medroxyprogesterone acetate (MPA) in combination with transdermal oestradiol (t-E) on cardiovascular disease (CVD) risk markers in women diagnosed with an early menopause and premature ovarian insufficiency (EMPOI).

Background: The European Society for Cardiology has identified carotid femoral pulse wave velocity (cfPWV) as the gold standard cardiogenic biomarker for risk stratification of arterial disease. Menopause has been shown to augment the age-dependent increase in arterial stiffness, with hormone replacement therapy (HRT) being the mainstay of management of women diagnosed with EMPOI. Read More

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Umbilical Cord Mesenchymal Stem Cells Ameliorate Premature Ovarian Insufficiency in Rats.

Evid Based Complement Alternat Med 2022 30;2022:9228456. Epub 2022 May 30.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Premature ovarian insufficiency (POI) or premature ovarian failure (POF) is known as a state of hypergonadotropic hypogonadism. Stem cell therapy is expected to be used in the treatment of POI. The aim of the present study was to explore the feasibility and effectiveness of umbilical cord mesenchymal stem cell (UCMSC) transplantation for the treatment of POI in a rat model of POI induced by cyclophosphamide (CTX) injection. Read More

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Diagnosis of Idiopathic Premature Ovarian Failure by Color Doppler Ultrasound under the Intelligent Segmentation Algorithm.

Comput Math Methods Med 2022 25;2022:2645607. Epub 2022 May 25.

Department of Gynaecology, The First People's Hospital of Huaihua, Huaihua, 418000 Hunan, China.

The aim of this study was to explore the application value of transvaginal color Doppler ultrasound based on the improved mean shift algorithm in the diagnosis of idiopathic premature ovarian failure (POF). In this study, 80 patients with idiopathic POF were selected and included in the experimental group, and 40 volunteers who underwent health examinations during the same period were selected and included in the control group, who underwent transvaginal Doppler ultrasound examination. At the same time, an improved mean shift algorithm was proposed based on artificial intelligence technology and applied to ultrasound image processing. Read More

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Abnormal Trabecular Bone Score, Lower Bone Mineral Density and Lean Mass in Young Women With Premature Ovarian Insufficiency Are Prevented by Oestrogen Replacement.

Front Endocrinol (Lausanne) 2022 19;13:860853. Epub 2022 May 19.

Department of Endocrinology, Monash Health, Melbourne, VIC, Australia.

Background: Low bone density (BMD) and fractures commonly affect women with premature ovarian insufficiency (POI). However, bone microarchitecture and body composition data are lacking.

Objective: To assess and characterise musculoskeletal phenotype and effects of oestrogen replacement therapy (ERT) in women with POI. Read More

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Incidental findings on coronary computed tomography in women with selected reproductive disorders.

Insights Imaging 2022 Jun 4;13(1):96. Epub 2022 Jun 4.

Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.

Objective: To determine the prevalence of incidental findings (IFs) on coronary computed tomography (CCT) in women aged 45-55 years and previously diagnosed with reproductive disorders such as polycystic ovary syndrome (PCOS), premature ovarian insufficiency (POI) or preeclampsia (PE).

Methods: A total of 486 middle-aged women with PCOS (n = 101), POI (n = 97) or a history of PE (n = 288) underwent a CCT as part of a prior prospective study. IFs were categorized by their significance (minor, moderate and major). Read More

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An anatomical variation during para-aortic lymphadenectomy.

J Visc Surg 2022 Jun 1. Epub 2022 Jun 1.

Department of Surgical Oncology, Institut du Cancer de Montpellier (ICM Val d'Aurelle), 208, avenue des Apothicaires, 34298 Montpellier, France. Electronic address:

Failure to identify anatomical variations may contribute to surgical errors or perioperative complications during abdominal and oncological surgery. We report the case of an anatomical variation of the inferior vena cava revealed during para-aortic lymphadenectomy for advanced ovarian cancer. Due to renal insufficiency, preoperative CT-scan was performed without contrast injection and the variation was not clearly detected. Read More

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Characteristics and clinicopathological features of patients with ovarian metastasis of endometrial cancer: a retrospective study.

J Obstet Gynaecol 2022 Jun 2:1-7. Epub 2022 Jun 2.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

There are no criteria for patient selection for ovarian-preserving surgery for endometrial cancer (EC). In this study, intraoperative findings of ovarian swelling (OvS) and the clinicopathological features of patients with EC with or without ovarian metastasis were analysed to identify risk factors for ovarian metastasis. Patients who underwent surgery for EC between 2012 and 2019 at our hospital were enrolled. Read More

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Bioengineering trends in female reproduction: a systematic review.

Hum Reprod Update 2022 Jun 2. Epub 2022 Jun 2.

Fundación IVI, IVI-RMA Global, Valencia, Spain.

Background: To provide the optimal milieu for implantation and fetal development, the female reproductive system must orchestrate uterine dynamics with the appropriate hormones produced by the ovaries. Mature oocytes may be fertilized in the fallopian tubes, and the resulting zygote is transported toward the uterus, where it can implant and continue developing. The cervix acts as a physical barrier to protect the fetus throughout pregnancy, and the vagina acts as a birth canal (involving uterine and cervix mechanisms) and facilitates copulation. Read More

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Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism.

Case Rep Obstet Gynecol 2022 19;2022:4655249. Epub 2022 May 19.

Department of Obstetrics and Gynecology, Lucerne Cantonal Hospital, Switzerland.

Thalassaemic syndromes are among the most common haemoglobinopathies and are associated with high morbidity and mortality. Because of the various treatments, a secondary endocrinopathy due to iron overload-haemosiderosis-can occur, causing hypopituitarism leading to hypogonadotropic hypogonadism (HH) and infertility. We present a case of secondary amenorrhoea in a patient with beta-thalassaemia and a history of multiple therapies in her adolescence, such as multiple transfusions, chemotherapy, and allogeneic bone marrow transplantation, who presented with HH and premature ovarian insufficiency. Read More

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The use of intraovarian injection of autologous platelet rich plasma (PRP) in patients with poor ovarian response and premature ovarian insufficiency.

Curr Opin Obstet Gynecol 2022 06;34(3):133-137

IVIRMA New Jersey, Basking Ridge, New Jersey.

Purpose Of Review: Intraovarian injection of platelet rich plasma (PRP) is a novel treatment for patients with poor ovarian response (POR) and primary ovarian insufficiency (POI). This article reviews the latest literature on the effect of PRP on markers of ovarian reserve, oocyte and embryo yield, and live birth for these poor prognosis patients.

Recent Findings: Several case series and one prospective trial have demonstrated improvements in markers of ovarian reserve in patients with POI and POR and improved oocyte and embryo yields in patients with POR. Read More

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A decade of discovery: the stunning progress of premature ovarian insufficiency research in China.

Biol Reprod 2022 May 25. Epub 2022 May 25.

Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Premature ovarian insufficiency (POI) is one of key aspects of ovarian infertility. Due to early cession of ovarian function, POI imposes great challenges on the physiological and psychological health of women, and becomes a common cause of female infertility. In the worldwide, there has been a special outpouring of concern for about four million reproductive-aged women suffering from POI in China. Read More

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A truncating variant of RAD51B associated with primary ovarian insufficiency provides insights into its meiotic and somatic functions.

Cell Death Differ 2022 May 27. Epub 2022 May 27.

Molecular Mechanisms Program, Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer (CSIC-Universidad de Salamanca), Salamanca, Spain.

Primary ovarian insufficiency (POI) causes female infertility by abolishing normal ovarian function. Although its genetic etiology has been extensively investigated, most POI cases remain unexplained. Using whole-exome sequencing, we identified a homozygous variant in RAD51B -(c. Read More

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Practical Prediction Model for Ovarian Insufficiency after Radiation.

Rev Bras Ginecol Obstet 2022 May 26. Epub 2022 May 26.

Gynecology Department, Universidade Estadual Paulista "Júlio de Mesquita Filho", Botucatu, SP, Brazil.

Objective:  The present study aimed to develop a useful mathematical model that predicts the age at which premature ovarian insufficiency might occur after teletherapy radiation. A diagnosis of premature or early menopause has physical and psychological consequences, so women may need support and long-term medical follow-up.

Methods:  To correlate ovarian radiation dose with ovarian function, we used the formula described by Wallace et al. Read More

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