187,423 results match your criteria Ovarian Insufficiency


Impairment of the antifibrotic prostaglandin E pathway may influence neutrophil extracellular traps-induced fibrosis in the mare endometrium.

Domest Anim Endocrinol 2018 Nov 3;67:1-10. Epub 2018 Nov 3.

Department of Morphology and Function, CIISA- Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.

Prostaglandin E (PGE) has contradictory effects in many organs. It may have proinflammatory, anti-inflammatory, or anti-fibrotic roles, depending on the type of receptors to which it binds. By signaling through its receptors EP2 and EP4, PGE mediates anti-inflammatory and anti-fibrotic actions. Read More

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November 2018
2 Reads

A PALB2 truncating mutation: Implication in cancer prevention and therapy of Hereditary Breast and Ovarian Cancer.

Breast 2018 Nov 29;43:91-96. Epub 2018 Nov 29.

Cancer Genetics Group, Institute of Genetics and Molecular Biology (UVa-CSIC), Sanz y Forés 3, 47003 Valladolid, Spain. Electronic address:

Explaining genetic predisposition in Hereditary Breast and Ovarian Cancer (HBOC) families without BRCA mutations is crucial. Germline PALB2 inactivating mutations were associated with an increased risk of HBOC due to its role in DNA repair through cooperation with BRCA proteins. The prevalence and penetrance of PALB2 mutations in Spanish HBOC patients remains unexplained. Read More

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November 2018
2 Reads

Electro-acupuncture attenuates the mice premature ovarian failure via mediating PI3K/AKT/mTOR pathway.

Life Sci 2018 Dec 3. Epub 2018 Dec 3.

College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:

Aims: Electro-acupuncture (EA) is frequently recommended as a complementary therapy for premature ovarian failure (POF) in the clinical. However, little information exists about its potential treatment mechanisms. The study was designed to observe the effect of EA to ovarian function and fertility in POF mice model, and investigated its potential mechanisms on PI3K/AKT/mTOR signaling pathway. Read More

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December 2018

Aberrations in the female reproductive organs and a role of telocytes in a rat model of anorexia nervosa.

Folia Med Cracov 2018 ;58(3):115-125

Department of Pathophysiology, Jagiellonian University Medical College, Czysta 18, Kraków, Poland.

Background: Anorexia nervosa is a widely prevalent eating disorder that o en leads to life-threatening complications. Since it mostly concerns females, many authors have focused on studying the reproductive system in anorexic women. Recently discovered telocytes may give a new insight into the pathophysiology of gynecological complications in these patients. Read More

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January 2018
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LINC01118 Modulates Paclitaxel Resistance of Epithelial Ovarian Cancer by Regulating miR-134/ABCC1.

Authors:
Cong Shi Min Wang

Med Sci Monit 2018 Dec 6;24:8831-8839. Epub 2018 Dec 6.

Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China (mainland).

BACKGROUND Epithelial ovarian cancer (EOC) has a high mortality rate and is a common malignant tumor of women, seriously impairing health. Chemoresistance is one of the major causes of poor prognosis. Therefore, analyzing the molecular mechanism of paclitaxel resistance has great significance. Read More

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December 2018
1 Read

Bladder hematoma: a complication from an oocyte retrieval procedure.

JBRA Assist Reprod 2018 Dec 6. Epub 2018 Dec 6.

Fertipraxis-Centro de Reprodução Humana- RJ, Brazil.

Introduction: More than one million fertilization cycles are performed every year. The incidence of serious complications associated with transvaginal oocyte pick-up is low, but the procedure is not risk-free. Risks are inherent to procedures in which thin needles and sharp instruments are introduced into the vaginal wall and ovarian capsule to access the ovaries. Read More

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December 2018
2 Reads

Practice patterns of surgery for advanced ovarian cancer: analysis from international surveys.

Jpn J Clin Oncol 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: We investigated the practice patterns of surgery for advanced ovarian cancer (AOC) through relevant international surveys.

Methods: After searching for 878 studies on surgery for AOC till 2017, we extracted 18 questions with similar query and answer formats from eight studies. Among them, 5 and 13 were classified as comprehensive and procedure information. Read More

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December 2018
2 Reads

Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response.

Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.

Institute of Cell Biology and Genes and Development Group, CDBS Hugh Robson Building, University of Edinburgh, Edinburgh, UK.

Study Question: Does ovarian follicle activation by phosphatase homologue of chromosome-10 (PTEN) inhibition affect DNA damage and repair in bovine oocytes and granulosa cells?

Summary Answer: PTEN inhibition promotes bovine non-growing follicle activation but results in increased DNA damage and impaired DNA repair capacity in ovarian follicles in vitro.

What Is Known Already: Inhibition of PTEN is known to activate primordial follicles but may compromise further developmental potential. In breast cancer cells, PTEN inhibition represses nuclear translocation of breast cancer susceptibility 1 (BRCA1) and Rad51; this impairs DNA repair resulting in an accumulation of damaged DNA, which contributes to cell senescence. Read More

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December 2018

Luteal granulosa cells from natural cycles are more capable of maintaining their viability, steroidogenic activity and LH receptor expression than those of stimulated IVF cycles.

Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.

Graduate School of Health Sciences, Koc University, Davutpasa, Topkapi, Istanbul, Turkey.

Study Question: Are there any differences in the molecular characteristics of the luteal granulosa cells (GC) obtained from stimulated versus non-stimulated (natural) IVF cycles that may help explain the defective luteal phase in the former?

Summary Answer: Luteal GC of stimulated IVF cycles, particularly those of agonist-triggered antagonist cycles, are less viable ex vivo, express LH receptor and anti-apoptotic genes at lower levels, undergo apoptosis earlier and fail to maintain their estradiol (E2) and progesterone (P4) production in comparison to natural cycle GC.

What Is Known Already: Luteal function is defective in stimulated IVF cycles, which necessitates P4 and/or hCG administration (known as luteal phase support) in order to improve clinical pregnancy rates and prevent miscarriage. The luteal phase becomes shorter and menstruation begins earlier than a natural cycle if a pregnancy cannot be achieved, indicative of early demise of corpus luteum (premature luteolysis). Read More

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December 2018

Chronic tubal pregnancy manifesting as a heterogeneous adnexal mass with prominent neovascularization in a woman with a negative serum β-human chorionic gonadotropin level.

J Obstet Gynaecol Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics and Gynecology, Gifu Prefectural Tajimi Hospital, Tajimi, Japan.

A 41-year-old woman (gravida 2, para 1) underwent elective termination of pregnancy at approximately 7 weeks of gestation. At 1 month after the elective abortion, she was referred due to abnormal results in a cervical cytological examination. Transvaginal ultrasonography showed a heterogeneous mass of 16 mm in diameter in the left adnexal region. Read More

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December 2018

Trends in the incidence and mortality of cancer in Saudi Arabia.

Saudi Med J 2018 Dec;39(12):1259-1262

Biochemistry Department, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia. E-mail.

Objectives: To analyze the overall trends in cancer incidence and mortality in Saudi Arabia between 1990 and 2016.   Methods: Data were retrieved through a Global Burden of Disease (GBD, 2016) database (Viz Hub) that is developed by the Institute for Health Metrics and Evaluation at the University of Washington. Results: The incidence of cancer increased around 26-fold for thyroid cancer; approximately 10-fold in breast, colon, bladder and uterine cancers; 8-fold for prostate cancer; 5-fold for renal cancer; 4-fold for pancreatic and ovarian cancer; 3. Read More

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December 2018
3 Reads

Follicular Development and Reproductive Characteristics in Four Species of Brazilian Tropidurus Lizards.

Zoolog Sci 2018 Dec;35(6):553-563

4 Biology Institute, State University of Campinas. Monteiro Lobato st., 255 - Cidade Universitária, Campinas, São Paulo 13083-862, Brazil.

The follicular development and reproductive characteristics of four species of oviparous lizards in the Tropidurus torquatus group were anatomically and histologically evaluated. We measured specimens, recorded the number of follicles and eggs, and removed the right ovary of each individual, which we processed according to histological routine and photo-documented. For all species, ovaries were divided into a cortical germinal bed, where oogonia and stage I oocytes are located, and a medullar stroma, where the remaining follicular developmental stages occur. Read More

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December 2018

Targeted Feature Extraction in MALDI Mass Spectrometry Imaging to Discriminate Proteomic Profiles of Breast and Ovarian Cancer.

Proteomics Clin Appl 2018 Dec 6:e1700168. Epub 2018 Dec 6.

University of Bremen, Bremen, Germany.

Purpose: To develop a mass spectrometry imaging (MSI) based workflow for extracting m/z values related to putative protein biomarkers and using these for reliable tumor classification.

Experimental Design: Given a list of putative breast and ovarian cancer biomarker proteins, we extracted a set of related m/z values from heterogeneous MSI datasets derived from formalin-fixed paraffin-embedded tissue material. Based on these features, a linear discriminant analysis classification model was trained to discriminate the two tumor types. Read More

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December 2018

Effect of sex hormone-binding globulin polymorphisms on the outcome of in vitro fertilization-embryo transfer for polycystic ovary syndrome patients: A case-control study.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Gynecology, Linyi People's Hospital, Linyi, China.

Polycystic ovary syndrome (PCOS), known as a common endocrine disorder among females, plagues many PCOS patients. The current study aimed to explore the correlations of sex hormone-binding globulin (SHBG) polymorphisms with the outcome of in vitro fertilization-embryo transfer (IVF-ET) in PCOS patients. PCOS patients who underwent IVF-ET and patients with non-PCOS-related infertility were selected in the study. Read More

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December 2018

A four-gene signature predicts the efficacy of paclitaxel-based neoadjuvant therapy in human epidermal growth factor receptor 2-negative breast cancer.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, China.

Neoadjuvant chemotherapy (NAC) is the major preoperative treatment of breast cancer (BC) with negative human epidermal growth factor receptor 2 (HER2), and the efficacy of NAC and the optimization of regimen are under intensive research. The current study aimed to define the predictive biomarkers for paclitaxel (PTX) response in NAC of HER2-negative BC. Data from GSE25065, GSE26065, GSE41998, as well as drug sensitivity data of breast and ovarian cancer cell line from NCI60, were used. Read More

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December 2018
1 Read

[Acute Pelvic pain in women-gynecological causes].

Radiologe 2018 Dec 5. Epub 2018 Dec 5.

Universitätsinstitut für Radiologie, Universitätsklinikum der Paracelsus Medizinischen Privatuniversität, Müllner Hauptstraße 48, 5020, Salzburg, Österreich.

Background: Acute pelvic pain in women may be due to gynecological, gastrointestinal, and urinary tract disorders. Ectopic pregnancy (EP), pelvic inflammatory disease (PID), and ruptured ovarian cysts are the most common gynecological causes for acute pelvic pain and their diagnosis can be challenging.

Methods: Patient history, clinical examination, and blood tests as well as patient age and potential pregnancy status help to establish the correct diagnosis. Read More

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December 2018
2 Reads

Risk Model in Women with Ovarian Cancer Without Mutations.

Open Med (Wars) 2018 25;13:565-574. Epub 2018 Nov 25.

Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland.

Ovarian cancer is characterised by the greatest mortality among all tumors of the reproductive tract. This study included 246 patients which consisted of 136 women with ovarian cancer without genetic mutation and 110 women with benign ovarian cysts. We created two mathematical logic models containing positive and negative risk factors of ovarian cancer such as: age at last menstruation cycle, patient age, OC, HRT, smoking, education status, and alcohol consumption. Read More

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November 2018

Prognosis Analysis of Histone Deacetylases mRNA Expression in Ovarian Cancer Patients.

J Cancer 2018 11;9(23):4547-4555. Epub 2018 Nov 11.

Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.

Histone deacetylases modulate the dynamic balance of histone acetylation and deacetylation in cells, which participate in epigenetic regulations. Accumulated evidence has demonstrated that histone deacetylases are associated with angiogenesis, cell proliferation and survival in a variety of human cancers. However, the expression and distinct prognostic value of histone deacetylases in ovarian cancer have not been well elucidated. Read More

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November 2018
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Myotilin, a New Topotecan Resistant Protein in Ovarian Cancer Cell Lines.

J Cancer 2018 22;9(23):4413-4421. Epub 2018 Oct 22.

Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland.

Low effectiveness of chemotherapy in ovarian cancer results from development of drug resistance during treatment. Topotecan (TOP) is a chemotherapeutic drug used in second-line chemotherapy of this cancer. Unfortunately, during treatment cancer can develop diverse cellular and tissue specific mechanisms of resistance to cytotoxic drugs. Read More

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October 2018

Prognostic Values of LAPTM4B-35 in Human Cancer: A Meta-analysis.

J Cancer 2018 21;9(23):4355-4362. Epub 2018 Oct 21.

Department of Breast Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.

: Lysosome-associated protein transmembrane-4β-35(LAPTM4B-35) has been observed overexpressed in multiple malignant tumors. However, the prognostic value of LAPTM4B-35 remains controversial. Therefore, we conducted a meta-analysis to evaluate the prognostic value of LAPTM4B-35 in human cancers. Read More

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October 2018

ABO Blood Type Has No Impact on Survival in Patients with Epithelial Ovarian Cancer.

J Cancer 2018 21;9(23):4334-4340. Epub 2018 Oct 21.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

Evidence for an association between ABO blood type and epithelial ovarian cancer (EOC) survival has so far been limited and conflictive. This study applied a retrospective cohort and included 627 EOC patients diagnosed at Shengjing Hospital of China Medical University between 2011 and 2015. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) between the ABO blood type and progression-free survival (PFS) and overall survival (OS) of EOC patients were assessed using multivariable Cox proportional regression models. Read More

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October 2018
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Management Of Synchronous Krukenberg Tumors From Gastric Cancer: a Single-center Experience.

J Cancer 2018 20;9(22):4197-4203. Epub 2018 Oct 20.

Department of Abdominal Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China.

Whether metastasectomy improves prognosis of gastric cancer patients with ovarian metastases (Krukenberg tumors) is not clear. In this study, we examined the survival benefit of metastasectomy combined with chemotherapy for treatment of synchronous Krukenberg tumors from gastric cancer and identified the prognostic factors. The subjects of this study were patients diagnosed as synchronous Krukenberg tumors of gastric origin in the period between December 2004 and December 2015. Read More

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October 2018

Prognostic Influence of the Time Interval between Surgery and Chemotherapy in Epithelial Ovarian Cancer.

J Cancer 2018 18;9(22):4172-4178. Epub 2018 Oct 18.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

The influence of time to chemotherapy (TTC) on recurrence and survival among epithelial ovarian cancer (EOC) patients still remains unknown. This single center retrospective cohort study was conducted on 489 EOC patients who underwent surgery followed by taxane- plus platinum-based chemotherapy in the Shengjing Hospital of China Medical University between 2011 and 2015. The Multivariate cox proportional regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for progression-free survival (PFS) and overall survival (OS) after adjustment for potential confounders. Read More

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October 2018

A two-step strategy for identification of plasma protein biomarkers for endometrial and ovarian cancer.

Clin Proteomics 2018 1;15:38. Epub 2018 Dec 1.

1Department of Immunology, Genetics, and Pathology, Biomedical Center, Science for Life Laboratory (SciLifeLab) Uppsala, Uppsala University, Box 815, 75108 Uppsala, Sweden.

Background: Over 500,000 women worldwide are diagnosed with ovarian or endometrial cancer each year. We have used a two-step strategy to identify plasma proteins that could be used to improve the diagnosis of women with an indication of gynecologic tumor and in population screening.

Methods: In the discovery step we screened 441 proteins in plasma using the proximity extension assay (PEA) and five Olink Multiplex assays (CVD II, CVD III, INF I, ONC II, NEU I) in women with ovarian cancer (n = 106), endometrial cancer (n = 74), benign ovarian tumors (n = 150) and healthy population controls (n = 399). Read More

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December 2018

Identification of potential key genes associated with ovarian clear cell carcinoma.

Cancer Manag Res 2018 8;10:5461-5470. Epub 2018 Nov 8.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Eastern District, Beijing 100730, China,

Background: Ovarian cancer is the major cause of death from cancer among females worldwide. Ovarian clear cell carcinoma (OCCC) is considered a distinct histopathologic subtype with worse prognosis and resistance to conventional chemotherapy.

Materials And Methods: We analyzed five microarray datasets derived from the Gene Expression Omnibus database. Read More

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November 2018

The prognostic roles of mRNAs of the exosomes derived from bone marrow stromal cells in common malignancies: a bioinformatic study.

Authors:
Fei Zhao Yan-Qiu Yu

Onco Targets Ther 2018 12;11:7979-7986. Epub 2018 Nov 12.

Department of Pathophysiology, College of Basic Medicine Science, China Medical University, Shenyang, Liaoning, China,

Background: The inclusion of exosomes enters the recipient cells by means of endocytosis or direct fusion for information exchange between cells and cells. The inclusion of BMSCs-exo helps to guide the diagnosis and prognosis of cancer, especially cancer.

Purpose: This research was to systematically elucidate the prognostic value of mRNAs of the exosomes derived from bone marrow stromal cells (BMSCs) in common malignant neoplasms, such as breast cancer, ovarian cancer, lung cancer, and gastric cancer. Read More

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November 2018

Cisplatin-induced immune modulation in ovarian cancer mouse models with distinct inflammation profiles.

Oncogene 2018 Dec 5. Epub 2018 Dec 5.

Magee Womens Research Institute, Pittsburgh, Pennsylvania, USA.

The backbone of ovarian cancer treatment is platinum-based chemotherapy and aggressive surgical debulking. New therapeutic approaches using immunotherapy via immune checkpoint blockade, which have demonstrated clinical efficacy in other tumor types, have been less promising in ovarian cancer. To increase their clinical efficacy, checkpoint inhibitors are now being tested in clinical trials in combination with chemotherapy. Read More

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December 2018
1 Read

DHS (trans-4,4'-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2).

Oncogene 2018 Dec 5. Epub 2018 Dec 5.

Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Since inhibition of DNA replication can lead to replication fork stalling, resulting in DNA damage and apoptotic death, inhibitors of DNA replication are commonly used in cancer chemotherapy. Ribonucleotide reductase (RNR) is the rate-limiting enzyme in the biosynthesis of deoxyribonucleoside triphosphates (dNTPs) that are essential for DNA replication and DNA damage repair. Read More

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December 2018

Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer.

Br J Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Background: Advanced cancer causes necrosis and releases damage-associated molecular patterns (DAMPs). Mitochondrial DAMPs activate neutrophils, including generation of neutrophil extracellular traps (NETs), which are injurious, thrombogenic, and implicated in metastasis. We hypothesised that extracellular mitochondrial DNA (mtDNA) in ascites from patients with epithelial ovarian cancer (EOC) would correlate with worse outcomes. Read More

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December 2018

Interaction of ovarian steroidogenesis and clock gene expression modulated by bone morphogenetic protein-7 in human granulosa cells.

Endocr J 2018 Dec 5. Epub 2018 Dec 5.

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kitaku, Okayama 700-8558, Japan.

A functional link between clock gene expression and ovarian steroidogenesis was studied using human granulosa KGN cells. Similarities between changes in the mRNA and protein expression levels of Bmal1 and Clock and those of Per2 and Cry1 were found in KGN cells after treatment with forskolin. Among the interrelationships between the expression levels of clock and steroidogenic factors, Clock mRNA had a strongly positive correlation with P450arom and a negative correlation with 3βHSD. Read More

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December 2018
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IL-6 mediates platinum-induced enrichment of ovarian cancer stem cells.

JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.

Medical Sciences, Cell, Molecular and Cancer Biology Program, Indiana University School of Medicine, Indiana University Bloomington (IUB), Bloomington, Indiana, USA.

In high-grade serous ovarian cancer (OC), chemotherapy eliminates the majority of tumor cells, leaving behind residual tumors enriched in OC stem cells (OCSC). OCSC, defined as aldehyde dehydrogenase-positive (ALDH+), persist and contribute to tumor relapse. Inflammatory cytokine IL-6 is elevated in residual tumors after platinum treatment, and we hypothesized that IL-6 plays a critical role in platinum-induced OCSC enrichment. Read More

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December 2018
1 Read

Construction and validation of a prediction model to minimize twin rates at preserved high live birth rates after IVF.

Reprod Biomed Online 2018 Nov 14. Epub 2018 Nov 14.

Department of Women's and Children's Health, Uppsala University, Akademiska Sjukhuset, Uppsala S-751 85, Sweden; Carl von Linné Clinic, Uppsala Science Park, Uppsala S-751 83, Sweden; Centre for Reproductive Biology in Uppsala, University of Agricultural Science and Uppsala University, Uppsala S-750 07, Sweden.

Research Question: Elective single-embryo transfer (eSET) at blastocyst stage is widely used to reduce the frequency of multiple pregnancies after IVF. There are, however, concerns about increased risks for the offspring with prolonged embryo culture. Is it possible to select embryos for transfer at the early cleavage stage and still achieve low twin rates at preserved high live birth rates?

Design: A prediction model (PM) was developed to optimize eSET based on variables known 2 days after oocyte retrieval (fresh day 2 embryo transfers; double-embryo transfers 1999-2002 (n=2846) and SET 1999-2003 (n=945); n total=3791). Read More

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November 2018

STON2 negatively modulates stem-like properties in ovarian cancer cells via DNMT1/MUC1 pathway.

J Exp Clin Cancer Res 2018 Dec 5;37(1):305. Epub 2018 Dec 5.

Department of Gynecologic Oncology; Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China.

Background: Cancer stem cells (CSCs) possess abilities of self-renewal and differentiation, have oncogenic potential and are regarded to be the source of cancer recurrence. However, the mechanism by which CSCs maintain their stemness remains largely unclear.

Methods: In this study, the cell line-derived ovarian CSCs (OCSCs), 3AO and Caov3, were enriched in serum-free medium (SFM). Read More

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December 2018
1 Read

Diffusion-weighted imaging and diffusion kurtosis imaging for early evaluation of the response to docetaxel in rat epithelial ovarian cancer.

J Transl Med 2018 Dec 5;16(1):340. Epub 2018 Dec 5.

Department of Radiology, Jinshan Hospital, Shanghai Medical College, University, 1508 Longhang Road, Shanghai, 201508, People's Republic of China.

Background: To investigate diffusion-weighted magnetic imaging (DWI) and diffusion kurtosis magnetic imaging (DKI) for the early detection of the response to docetaxel (DTX) chemotherapy in rat epithelial ovarian cancer (EOC).

Methods: 7,12-Dimethylbenz[A]anthracene was applied to induce orthotopic EOC in Sprague-Dawley rats. Rats with EOC were treated with DTX on day 0 (treatment group) or were left untreated (control group). Read More

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December 2018
1 Read

Role of BRCA Mutations in Cancer Treatment with Poly(ADP-ribose) Polymerase (PARP) Inhibitors.

Cancers (Basel) 2018 Dec 4;10(12). Epub 2018 Dec 4.

Department of Systems Medicine, University of Rome Tor Vergata, 00173 Rom, Italy.

Inhibition of poly(ADP-ribose) polymerase (PARP) activity induces synthetic lethality in mutated BRCA1/2 cancers by selectively targeting tumor cells that fail to repair DNA double strand breaks (DSBs). Clinical studies have confirmed the validity of the synthetic lethality approach and four different PARP inhibitors (PARPi; olaparib, rucaparib, niraparib and talazoparib) have been approved as monotherapies for BRCA-mutated or platinum-sensitive recurrent ovarian cancer and/or for BRCA-mutated HER2-negative metastatic breast cancer. PARPi therapeutic efficacy is higher against tumors harboring deleterious germline or somatic BRCA mutations than in BRCA wild-type tumors. Read More

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December 2018
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Hysteroscopic Placement of Platinum Microinsert in Patients With Hydrosalpinx Before In Vitro Fertilization and Embryo Transfer.

J Minim Invasive Gynecol 2018 Nov 30. Epub 2018 Nov 30.

Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, China; Institute of Reproductive and Stem Cell Engineering, Basic Medicine College, Central South University, Changsha, China; Key Laboratory of Reproductive and Stem Cell Engineering, Ministry of Health, Changsha, China. Electronic address:

Study Objective: To investigate the effectiveness of Tornado and Hilal (Cook Medical, Bloomington, Indiana, USA) hysteroscopic proximal tubal occlusion (HPTO) for hydrosalpinx (HX) treatment prior to in vitro fertilization (IVF) and embryo transfer (ET) in patients with dense pelvic adhesions or low ovarian reserve.

Design: Retrospective study of patients treated between May 2014 and May 2016 (Canadian Task Force classification III).

Setting: University-affiliated center. Read More

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November 2018

Ovarian cancer stem cells and their role in drug resistance.

Int J Biochem Cell Biol 2018 Nov 30. Epub 2018 Nov 30.

School of Pharmacy & Biomedical Science, Curtin University, Curtin Health Innovative Research Institute, Australia. Electronic address:

Ovarian cancer is typically diagnosed at advanced stages (III or IV), with metastasis ensuing at stage III. Complete remission is infrequent and is not achieved in almost half of the women diagnosed with ovarian cancer. Consequently, management and treatment of this disease is challenging as many patients are faced with tumour recurrence disseminating to surrounding organs further complicated with acquired chemo-resistance. Read More

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November 2018
1 Read

An analysis of the influence of infection on overall survival rates, following modified posterior pelvic exenteration for advanced ovarian cancer.

Ginekol Pol 2018 ;89(11):618-626

Clinical Department of Gynecological Oncology, Professor Franciszek Lukaszczyk Oncology Center, Bydgoszcz, Poland; Department of Oncology, Radiotherapy and Oncological Gynecology, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.

Objectives The aim of our study has been to determine the association between the appearance of infection after modified posterior pelvic exenteration (MPE) and TTC (time to adjuvant chemotherapy) and to examine whether the infection impacts clinical results by delaying the start of chemotherapy. Material and methods The present, retrospective study analyzed 77 patients who had undergone MPE followed by adjuvant chemotherapy. Either no residual tumor or tumor less than 2. Read More

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January 2018

Risk factors related to the recurrence of endometrioma in patients with long-term postoperative medical therapy.

Ginekol Pol 2018 ;89(11):611-617

Department of Obstetrics and Gynecology, Pusan National University School of Medicine Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

Objectives: The purpose of this study was to identify clinical risk factors for the recurrence of ovarian endometrioma after ovarian cystectomy in Korean women with long-term postoperative medical therapy.

Material And Methods: A total of 134 patients who were surgically treated for endometriotic cysts at Pusan National University Hospital were included in this retrospective study. All patients received long-term postoperative medical treatment for at least 12 months after the first-line conservative surgery. Read More

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January 2018

Vitamin D and overall cancer risk and cancer mortality: a Mendelian randomization study.

Hum Mol Genet 2018 Dec;27(24):4315-4322

QIMR Berghofer Medical Research Institute, Brisbane, Australia.

There is considerable debate regarding the role that 25-hydroxyvitamin D [25(OH)D] concentrations play in cancer risk or mortality, with earlier studies drawing mixed conclusions. Using data from the UK Biobank (UKB), we evaluate whether genetically predicted 25(OH)D concentrations are associated with overall cancer susceptibility and cancer mortality using five 25(OH)D genetic markers. Data comprised 438 870 white British UKB participants aged 37-73, including 46 155 cancer cases and 6998 cancer-specific deaths. Read More

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December 2018

Spawning performance, serum sex steroids, and ovarian histology in wild-caught Levantine scraper, Capoeta damascina (Valenciennes, 1842) treated with various doses of sGnRHa + domperidone.

J Anim Sci 2018 Dec;96(12):5253-5264

School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, AL.

As global aquaculture continues to expand, increasing efforts are focusing on assisted reproductive technologies. This study sought to test whether salmon GnRH [D-Arg6, Pro9NEt]) analogue (sGnRHa) + domperidone injection at 0.25 mL/body weight (BW; 5-μg sGnRHa + 2. Read More

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December 2018

Single-cell sequencing in ovarian cancer: a new frontier in precision medicine.

Curr Opin Obstet Gynecol 2018 Nov 30. Epub 2018 Nov 30.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women's Health.

Purpose Of Review: This article discusses the advances, applications and challenges of using single-cell RNA sequencing data in guiding treatment decisions for ovarian cancer.

Recent Findings: Genetic heterogeneity is a hallmark of ovarian cancer biology and underlies treatment resistance. Defining the different cell types present within a single ovarian cancer is difficult, but could ultimately lead to improvements in diagnosis and treatment. Read More

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November 2018

Downregulation of Extracellular Matrix and Cell Adhesion Molecules in Cumulus Cells of Infertile Polycystic Ovary Syndrome Women with and without Insulin Resistance.

Cell J 2019 Jan 18;21(1):35-42. Epub 2018 Nov 18.

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

Objective: The extracellular matrix (ECM) of the cumulus oocyte complex (COC) is composed of several molecules that have different roles during follicle development. This study aims to explore gene expression profiles for ECM and cell adhesion molecules in the cumulus cells of polycystic ovary syndrome (PCOS) patients based on their insulin sensitivity following controlled ovarian stimulation (COS).

Materials And Methods: In this prospective case-control study enrolled 23 women less than 36 years of age who participated in an intracytoplasmic sperm injection (ICSI) program. Read More

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January 2019

Overexpression of lncRNA snaR is correlated with progression and predicts poor survival of laryngeal squamous cell carcinoma.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi, China.

Long noncoding RNAs (lncRNA) snaR is a characterized oncogenic lncRNA in triple negative breast cancer and ovarian cancer, while its role in other human diseases is unknown. In the present study, we found that plasma levels of snaR were upregulated in patients with laryngeal squamous cell carcinoma (LSCC) than in healthy controls. Plasma levels of snaR increased with increase in AJCC stages. Read More

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December 2018

MNX1-AS1 is a novel biomarker for predicting clinical progression and poor prognosis in lung adenocarcinoma.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Department of Thoracic Surgery, Qingdao Huangdao District Central Hospital, Qingdao, Shandong, China.

Motor neuron and pancreas homeobox 1-antisense RNA1 (MNX1-AS1) is a novel long noncoding RNA and has been suggested to be overexpressed in human ovarian cancer and glioma. The role of MNX1-AS1 in lung cancer was still unknown. In our study, we observed levels of MNX1-AS1 expression through analyzing The Cancer Genome Atlas and found MNX1-AS1 expression was highly expressed in lung adenocarcinoma tissues compared with normal lung tissues, but there was no statistical difference between lung squamous cell carcinoma tissues and normal lung tissues. Read More

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December 2018

Novel BRCA1 Large Genomic Rearrangements in Italian Breast/Ovarian Cancer Patients.

Mol Diagn Ther 2018 Dec 1. Epub 2018 Dec 1.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Background: In recent years, the number of patients being offered BRCA1/2 testing has changed dramatically. Advances in high-throughput sequencing technology have led many diagnostic laboratories to test next-generation sequencing (NGS)-based platforms as the main technology for clinical testing. As a consequence, the proportion of novel BRCA1/2 variants detected has greatly increased. Read More

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December 2018
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Communication About Hereditary Cancers on Social Media: A Content Analysis of Tweets About Hereditary Breast and Ovarian Cancer and Lynch Syndrome.

J Cancer Educ 2018 Dec 3. Epub 2018 Dec 3.

Office of Public Health Genomics, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, 30329, USA.

Social media is increasingly being used as an information source and tool for individuals and organizations to share resources and engage in conversations about health topics. Because the public tends to learn about health topics and genetics from online social media sources, it is imperative to understand the amount, type, and quality of information being shared. We performed a retrospective analysis of tweets related to hereditary breast and ovarian cancer (HBOC) and Lynch syndrome (LS) between January 1, 2017 and December 31, 2017. Read More

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December 2018

Correction to: Anti-Müllerian hormone serum levels in systemic lupus erythematosus patients: influence of the disease severity and therapy on the ovarian reserve.

Endocrine 2018 Dec 1. Epub 2018 Dec 1.

Institute of Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy.

The original version of this article unfortunately contained a mistake in given and family names of all the authors. Read More

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December 2018

Lymphopenia after induction chemotherapy correlates with incomplete surgical resection in patients with advanced ovarian cancer.

Int J Clin Oncol 2018 Nov 30. Epub 2018 Nov 30.

Department of Gynecology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.

Background: Lymphopenia is associated with poor outcomes in patients with various cancers, but little is known about the prognostic impact of lymphopenia in patients with epithelial ovarian cancer (EOC) after induction chemotherapy (IC). This study investigated the prognostic significance of pre- and post-IC lymphopenia in patients with advanced EOC.

Methods: We reviewed medical records of 68 patients with stage III/IV ovarian, fallopian tube, or peritoneal cancer treated with IC at our institution between 2009 and 2017. Read More

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November 2018

Percutaneous drainage and management of fluid collections associated with necrotic or cystic tumors in the abdomen and pelvis.

Abdom Radiol (NY) 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiology, Louisiana State University Health, Shreveport, LA, USA.

Purpose: The purpose of the study was to evaluate the efficacy and safety of percutaneous drainage for palliation of symptoms and sepsis in patients with cystic or necrotic tumors in the abdomen and pelvis.

Materials And Methods: This is a single center retrospective study of 36 patients (18 men, mean age = 51.1 years) who underwent percutaneous drainage for management of cystic or necrotic tumors in the non-postoperative setting over an 11-year period. Read More

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November 2018