4,563 results match your criteria Ovarian Insufficiency


Gonadal Function Recovery in Patients With Advanced Hodgkin Lymphoma Treated With a PET-Adapted Regimen: Prospective Analysis of a Randomized Phase III Trial (AHL2011).

J Clin Oncol 2021 Jun 22:JCO2100068. Epub 2021 Jun 22.

Department of Haematology, University Hospital F Mitterrand and Inserm UMR1231, Dijon, France.

Purpose: The prospective, randomized AHL2011 trial demonstrated that the use of the doxorubicin, bleomycin, vinblastine, and dacarbazine regimen (ABVD) after two cycles of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) in early responders on the basis of a positron emission tomography (PET)-driven strategy was safe and minimized toxicity compared with standard 6 BEACOPP cycles. This substudy investigated the benefit of this strategy in gonadal function and fertility in patients under 45 years old.

Methods: Ovarian function was assessed by serum measurement of follicle-stimulating hormone (FSH), estradiol, and anti-müllerian hormone in women, and semen analysis, FSH, and testosterone levels were used to evaluate testicular function in men at baseline, end of treatment, and during 5 years of follow-up. Read More

View Article and Full-Text PDF

Influence of Autologous Activation of Ovaries by Stem Cells and Growth Factors on Endocrine and Reproductive Function of Patients with Ovarian Insufficiency-A Clinical Trial Study.

Int J Fertil Steril 2021 Jul 22;15(3):178-188. Epub 2021 Jun 22.

Department of Gynecology, Dubrovnik International University, Dubrovnik, Croatia.

Background: Premature ovarian failure (POF) can be found in 1% of women at the age of 35-40, mostly due to unknown causes. PI3K-Akt signaling is associated with both ovarian function and growth of primordial follicles. In this study, we examined the effects of autologous ovarian activation with stem cells and autologous growth factors on reproductive and endocrine function in patients with ovarian impairment. Read More

View Article and Full-Text PDF

The PREgnancy and FERtility (PREFER) Study Investigating the Need for Ovarian Function and/or Fertility Preservation Strategies in Premenopausal Women With Early Breast Cancer.

Front Oncol 2021 3;11:690320. Epub 2021 Jun 3.

Department of Internal Medicine and Medical Sciences (DiMI), School of Medicine, University of Genova, Genova, Italy.

Background: Offering ovarian function and/or fertility preservation strategies in premenopausal women with newly diagnosed breast cancer candidates to undergo chemotherapy is standard of care. However, few data are available on uptake and main reasons for refusing these options.

Methods: The PREFER study (NCT02895165) is an observational, prospective study enrolling premenopausal women with early breast cancer, aged between 18 and 45 years, candidates to receive (neo)adjuvant chemotherapy. Read More

View Article and Full-Text PDF

Ovarian Vein Embolization: How and When Should It Be Done?

Tech Vasc Interv Radiol 2021 Mar 16;24(1):100732. Epub 2021 Apr 16.

Associate Professor of Radiology, Section of Interventional Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL. Electronic address:

Pelvic Venous Disease (PeVD) is characterized by pelvic varicosities and chronic pelvic pain, defined as noncyclic pelvic pain that persists for more than 6 months. Pain and discomfort related to PeVD typically worsen with upright positioning and occur more frequently in multiparous and premenopausal women. The most common cause of PeVD is pelvic venous insufficiency (PVI) due to incompetent valves. Read More

View Article and Full-Text PDF

Pancreas in Hereditary Syndromes: Cross-sectional Imaging Spectrum.

Radiographics 2021 Jun 18:200164. Epub 2021 Jun 18.

From the Departments of Radiology (V.S.K., S.B., H.R.) and Pathology (A.N.), University of Texas Health at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229; Department of Radiology, Le Bonheur Children's Hospital, Memphis, Tenn (J.N.S.); Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston, Tex (A.C.M., S.R.P.); Department of Radiology, University of Wisconsin, Madison, Wis (M.G.L.); Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pa (A.D.); and Department of Radiology, Mayo Clinic, Scottsdale, Ariz (C.O.M.).

A wide spectrum of hereditary syndromes predispose patients to distinct pancreatic abnormalities, including cystic lesions, recurrent pancreatitis, ductal adenocarcinoma, nonductal neoplasms, and parenchymal iron deposition. While pancreatic exocrine insufficiency and recurrent pancreatitis are common manifestations in cystic fibrosis and hereditary pancreatitis, pancreatic cysts are seen in von Hippel-Lindau disease, cystic fibrosis, autosomal dominant polycystic kidney disease, and McCune-Albright syndrome. Ductal adenocarcinoma can be seen in many syndromes, including Peutz-Jeghers syndrome, familial atypical multiple mole melanoma syndrome, Lynch syndrome, hereditary breast and ovarian cancer syndrome, Li-Fraumeni syndrome, and familial pancreatic cancer syndrome. Read More

View Article and Full-Text PDF

Temporal transcriptomic landscape of postnatal mouse ovaries reveals dynamic gene signatures associated with ovarian aging.

Hum Mol Genet 2021 Jun 17. Epub 2021 Jun 17.

Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), State Key Laboratory of Genetic Engineering at School of Life Sciences, Human Phenome Institute, Fudan University, Shanghai 200011, China.

The ovary is the most important organ for maintaining female reproductive health, but it fails before most other organs. Aging-associated alterations in gene expression patterns in mammalian ovaries remain largely unknown. In this study, the transcriptomic landscape of postnatal mouse ovaries over the reproductive lifespan was investigated using bulk RNA sequencing in C57BL/6 mice. Read More

View Article and Full-Text PDF

Circadian Rhythms within the Female HPG Axis: From Physiology to Etiology.

Endocrinology 2021 Jun 14. Epub 2021 Jun 14.

Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

Declining female fertility has become a global health concern. It results partially from an abnormal circadian clock caused by unhealthy diet and sleep habits in modern life. The circadian clock system is a hierarchical network consisting of central and peripheral clocks. Read More

View Article and Full-Text PDF

Turning a Turner to a twin mother.

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Obstetrics and Gynecology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

Women with Turner syndrome (TS) are subfertile due to premature ovarian insufficiency. Most women require hormone replacement therapy for attaining menarche and assisted reproductive technology (ART) using donor oocytes, autologous oocytes or in-vitro fertilisation for conception. Irrespective of the karyotype, monosomy X (45, X) or mosaic pattern, women with TS hold a very high risk for pregnancy due to high mortality rate secondary to aortic dissection and severe pre-eclampsia. Read More

View Article and Full-Text PDF

Apoptotic mechanism of premature ovarian failure and rescue effect of Traditional Chinese Medicine: a review.

J Tradit Chin Med 2021 Jun;41(3):492-498

Department of Reproductive Center, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Social and environmental factors render premature ovarian failure (POF) as a major cause of decline or loss of female fertility. The natural pregnancy rate of patients with POF is only 5%-10%. Follicular atresia is the main factor in the pathogenesis of POF. Read More

View Article and Full-Text PDF

Management of Patients when Superficial Venous Disease Arises from Pelvic Escape Points.

Semin Intervent Radiol 2021 Jun 3;38(2):226-232. Epub 2021 Jun 3.

Department of Clinical Radiology and Surgery, Hospital of the University of Pennsylvania - Perelman School of Medicine, Philadelphia, Pennsylvania.

Chronic pelvic pain (CPP) is a common condition in women that carries with it significant morbidity. It is commonly seen in patients presenting to obstetrics and gynecology outpatient clinic visits. CPP is a presenting symptom of various pathologies including pelvic varicocele, pelvic adhesions, spastic colon syndrome, uterine fibroids, endometriosis, and psychosomatic disorders. Read More

View Article and Full-Text PDF

Fresh insight into premature ovarian insufficiency.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Department of Gynecological Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Premature ovarian insufficiency (POI) is one of the vital reasons of anovulatory infertility among women under 40 years old. However, because of the unacknowledged causative factor in most cases, it still remains a huge challenge in gynecology. Recently, the most promising opportunities in diagnosing are connected with the use of some serum biomarkers, such as interleukin-17 (IL-17), Frizzled-5 protein, Soggy-1 protein and other cytokines. Read More

View Article and Full-Text PDF

Next Generation Sequencing Should Be Proposed to Every Woman With "Idiopathic" Primary Ovarian Insufficiency.

J Endocr Soc 2021 Jul 1;5(7):bvab032. Epub 2021 Mar 1.

Sorbonne University Medicine, Paris, France.

Context: Primary ovarian insufficiency (POI) affects 1% of women under 40 years of age. POI is idiopathic in more than 70% of cases. Though many candidate genes have been identified in recent years, the prevalence and pathogenicity of abnormalities are still difficult to establish. Read More

View Article and Full-Text PDF

Different Clinical Manifestations Related to Subvirilization in Three XY Patients With the Same Pathogenic Variant of Steroidogenic Factor 1.

AACE Clin Case Rep 2021 Mar-Apr;7(2):145-148. Epub 2020 Dec 28.

Endocrinology Unit, División of Pediatric, Pontificia Universidad Católica, Santiago, Chile.

Objective: During the prenatal period, steroidogenic factor 1 is required for the development of the adrenal glands and for gonadal determination and differentiation, and after birth, it regulates gonadal progenitor cell formation and their survival. Here, we describe the clinical phenotype of three 46,XY patients (2 brothers and an unrelated subject) with disorder of sex development due to the same genetic variant.

Methods: All patients underwent hormonal and pelvic ultrasound studies. Read More

View Article and Full-Text PDF
December 2020

The Molecular Regulation in the Pathophysiology in Ovarian Aging.

Aging Dis 2021 Jun 1;12(3):934-949. Epub 2021 Jun 1.

1Department of Obstetrics and Gynaecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

The female reproductive system is of great significance to women's health. Aging of the female reproductive system occurs approximately 10 years prior to the natural age-associated functional decline of other organ systems. With an increase in life expectancy worldwide, reproductive aging has gradually become a key health issue among women. Read More

View Article and Full-Text PDF

Association between premature ovarian insufficiency and gut microbiota.

BMC Pregnancy Childbirth 2021 Jun 5;21(1):418. Epub 2021 Jun 5.

Affiliated Shenzhen Maternity&Child Healthcare Hospital, Southern Medical University, No. 3012, Fuqiang Road, Futian District, Shenzhen City, 518000, Guangdong Province, China.

Background: Premature ovarian insufficiency (POI) is characterized by impairment of ovarian function on a continuum before the age of 40 years. POI is affected by multiple factors. Considering new insights from recent gut microbiome studies, this study aimed to investigate the relationship between gut microbial community structure and POI. Read More

View Article and Full-Text PDF

Therapeutic Effects of Low-Intensity Pulsed Ultrasound on Premature Ovarian Insufficiency.

Ultrasound Med Biol 2021 Jun 1. Epub 2021 Jun 1.

State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, Chongqing, China. Electronic address:

We explored the therapeutic effects of low-intensity pulsed ultrasound (LIPUS) on a rat model of ovarian damage induced by cyclophosphamide. A total of 44 female rats with premature ovarian insufficiency induced by cyclophosphamide were randomly divided into two groups (an ultrasound group and a control group); 22 normal rats without premature ovarian insufficiency were also included as a third group. The ultrasound group was treated with LIPUS, while the other two groups received the same treatment but without any power output. Read More

View Article and Full-Text PDF

Comparing the Gonadotoxicity of Multiple Breast Cancer Regimens: Important Understanding for Managing Breast Cancer in Pre-Menopausal Women.

Breast Cancer (Dove Med Press) 2021 24;13:341-351. Epub 2021 May 24.

Department of Medical Oncology, U.O.C Clinica Di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genova, Italy.

Over the last several decades, improvements in breast cancer treatment have contributed to increased cure rates for women diagnosed with this malignancy. Consequently, great importance should be paid to the long-term side effects of systemic therapies. For young women (defined as per guideline ≤40 years at diagnosis) who undergo chemotherapy, one of the most impactful side effects on their quality of life is premature ovarian insufficiency (POI) leading to fertility-related problems and the side effects of early menopause. Read More

View Article and Full-Text PDF

Report of two siblings with APECED in Serbia: is there a founder effect of c.769C>T AIRE genotype?

Ital J Pediatr 2021 Jun 2;47(1):126. Epub 2021 Jun 2.

Endocrine Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.

Background: Autoimmune polyendocrinopathy-candidiasis-ectodermal-dystrophy (APECED) or autoimmune polyglandular syndrome Type 1 is a rare autosomal recessive syndrome. The disorder is caused by mutations in the AIRE (AutoImmune Regulator) gene. According to the classic criteria, clinical diagnosis requires the presence of at least two of three main components: chronic mucocutaneous candidiasis, hypoparathyroidism and primary adrenal insufficiency. Read More

View Article and Full-Text PDF

A case-control study of thallium exposure with the risk of premature ovarian insufficiency in women.

Arch Environ Occup Health 2021 Jun 3:1-10. Epub 2021 Jun 3.

MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.

Thallium exposure has been associated with female reproductive health, but little is known about its potential association with premature ovarian insufficiency (POI). In this study, a total of 169 patients with POI and 209 healthy women were recruited from Zhejiang province, China. Urinary thallium concentrations were significantly positively associated with the risk of POI [adjusted odds ratio (OR) = 1. Read More

View Article and Full-Text PDF

Estrogens and Progestogens in Triple Negative Breast Cancer: Do They Harm?

Cancers (Basel) 2021 May 21;13(11). Epub 2021 May 21.

Department of Medical Oncology, Erasmus MC Cancer Institute, University Medical Centre, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.

Triple-negative breast cancers (TNBC) occur more frequently in younger women and do not express estrogen receptor (ER) nor progesterone receptor (PR), and are therefore often considered hormone-insensitive. Treatment of premenopausal TNBC patients almost always includes chemotherapy, which may lead to premature ovarian insufficiency (POI) and can severely impact quality of life. Hormone replacement therapy (HRT) is contraindicated for patients with a history of hormone-sensitive breast cancer, but the data on safety for TNBC patients is inconclusive, with a few randomized trials showing increased risk-ratios with wide confidence intervals for recurrence after HRT. Read More

View Article and Full-Text PDF

WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis.

Commun Biol 2021 May 31;4(1):645. Epub 2021 May 31.

School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.

WDR62 is a scaffold protein involved in centriole duplication and spindle assembly during mitosis. Mutations in WDR62 can cause primary microcephaly and premature ovarian insufficiency. We have generated a genetrap mouse model deficient in WDR62 and characterised the developmental effects of WDR62 deficiency during meiosis in the testis. Read More

View Article and Full-Text PDF

Pregnancy in patients with systemic lupus erythematosus after cyclophosphamide therapy.

Lupus 2021 May 30:9612033211021163. Epub 2021 May 30.

Department of Rheumatology, Emory University, Atlanta, GA, USA.

Systemic lupus erythematosus (SLE) often affects females of reproductive age and Cyclophosphamide, an alkylating agent leading to premature ovarian insufficiency (POF) and labelled category D for pregnancy is used as induction therapy for severe manifestations of lupus. There have been multiple case series reflecting variable outcomes of pregnancies after cyclophosphamide use for cancers and autoimmune diseases. With increasing maternal age, we have an increasing population of lupus patients who may wish to conceive after having received cyclophosphamide therapy. Read More

View Article and Full-Text PDF

Structural study of the N-terminal domain of human MCM8/9 complex.

Structure 2021 May 22. Epub 2021 May 22.

School of Medicine, Sun Yat-Sen University, Guangdong 510006, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong 510006, China. Electronic address:

MCM8/9 is a complex involved in homologous recombination (HR) repair pathway. MCM8/9 dysfunction can cause genome instability and result in primary ovarian insufficiency (POI). However, the mechanism underlying these effects is largely unknown. Read More

View Article and Full-Text PDF

Premature Ovarian Insufficiency: Past, Present, and Future.

Front Cell Dev Biol 2021 10;9:672890. Epub 2021 May 10.

Department of Molecular Medicine, College of Medicine, Gachon University, Incheon, South Korea.

Premature ovarian insufficiency (POI) is the loss of normal ovarian function before the age of 40 years, a condition that affects approximately 1% of women under 40 years old and 0.1% of women under 30 years old. It is biochemically characterized by amenorrhea with hypoestrogenic and hypergonadotropic conditions, in some cases, causing loss of fertility. Read More

View Article and Full-Text PDF

Danggui Buxue Tang Rescues Folliculogenesis and Ovarian Cell Apoptosis in Rats with Premature Ovarian Insufficiency.

Evid Based Complement Alternat Med 2021 5;2021:6614302. Epub 2021 May 5.

Department of Gynaecology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Dade Road, Yuexiu District, Guangzhou 510120, Guangdong, China.

Premature ovarian insufficiency (POI) is a common female endocrine disease that is closely linked to ovarian function. Danggui Buxue Tang (DBT) is a classic prescription of traditional Chinese medicine that is helpful for rescuing ovarian function. However, the mechanism by which DBT rescues ovarian function remains unclear. Read More

View Article and Full-Text PDF

Therapeutic effects of puerarin on polycystic ovary syndrome: A randomized trial in Chinese women.

Medicine (Baltimore) 2021 May;100(21):e26049

Department of Obstetrics and Gynecology, Yuebei People's Hospital, Shaoguan, Guangdong Province, China.

Background: This study aims to assess the therapeutic effects of a well-known component (puerarin) obtained from a Chinese herb root in patients with polycystic ovary syndrome (PCOS).

Methods: Women with premature ovarian failure (POF) were assigned to the obese group (body mass index [BMI] ≥24 kg/m2 and waist hip ratio [WHR] >0.85) or non-obese group (group 3, n = 21). Read More

View Article and Full-Text PDF

Metabolic profile of women with premature ovarian insufficiency compared with that of age-matched healthy controls.

Maturitas 2021 Jun 20;148:33-39. Epub 2021 Apr 20.

Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China. Electronic address:

Objective: . To compare the metabolic profile of women with spontaneous premature ovarian insufficiency (POI) with that of age-matched healthy controls.

Study Design: . Read More

View Article and Full-Text PDF

[The Effect and Mechanism of Hyperin on Ovarian Reserve of Tripterygium Glycosides-Induced POI Mice].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 May;52(3):458-466

Department of Reproductive Medicine, Jiangsu Province Hospital of Chinese Medicine/Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.

Objective: To investigate the effect and mechanism of hyperin on the improvement of ovarian reserve of tripterygium glycosides (TG)-induced primary ovarian insufficiency (POI) in mice.

Methods: Adult female BALB/c mice were used as research subjects and were randomly assigned to the control group, POI model group and hyperin treatment group, with 40 mice in each group. TG was given at 40 mg/kg twice a day by gavage for 2 weeks to create the POI mouse model. Read More

View Article and Full-Text PDF

Identifying susceptibility genes for primary ovarian insufficiency on the high-risk genetic background of a fragile X premutation.

Fertil Steril 2021 May 17. Epub 2021 May 17.

Department of Human Genetics, Emory University, Atlanta, Georgia. Electronic address:

Objective: To identify modifying genes that explains the risk of fragile X-associated primary ovarian insufficiency (FXPOI).

Design: Gene-based, case/control association study, followed by a functional screen of highly ranked genes using a Drosophila model.

Setting: Participants were recruited from academic and clinical settings. Read More

View Article and Full-Text PDF

Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility.

Immunity 2021 May 12. Epub 2021 May 12.

Department of Histology and Embryology, University of Rijeka, Faculty of Medicine, B. Branchetta 20, 51000 Rijeka, Croatia; Center for Proteomics, University of Rijeka, Faculty of Medicine, B. Branchetta 20, 51000 Rijeka, Croatia. Electronic address:

Viral infections during pregnancy are a considerable cause of adverse outcomes and birth defects, and the underlying mechanisms are poorly understood. Among those, cytomegalovirus (CMV) infection stands out as the most common intrauterine infection in humans, putatively causing early pregnancy loss. We employed murine CMV as a model to study the consequences of viral infection on pregnancy outcome and fertility maintenance. Read More

View Article and Full-Text PDF