3,688 results match your criteria Ovarian Insufficiency


Oocyte cryopreservation for a female cancer patient after reaching adulthood.

Pediatr Int 2019 Feb 11. Epub 2019 Feb 11.

Departments of Human Health Science, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto, Japan.

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http://dx.doi.org/10.1111/ped.13752DOI Listing
February 2019
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The MCM8/9 complex: A recent recruit to the roster of helicases involved in genome maintenance.

DNA Repair (Amst) 2019 Feb 5;76:1-10. Epub 2019 Feb 5.

Department of Chemistry and Biochemistry, Baylor University, Waco, Texas, 76798, USA. Electronic address:

There are several DNA helicases involved in seemingly overlapping aspects of homologous and homoeologous recombination. Mutations of many of these helicases are directly implicated in genetic diseases including cancer, rapid aging, and infertility. MCM8/9 are recent additions to the catalog of helicases involved in recombination, and so far, the evidence is sparse, making assignment of function difficult. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15687864183031
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http://dx.doi.org/10.1016/j.dnarep.2019.02.003DOI Listing
February 2019
2 Reads

A hypothesis: Could telomere length and/or epigenetic alterations contribute to infertility in females with Turner syndrome?

Am J Med Genet C Semin Med Genet 2019 Feb 11. Epub 2019 Feb 11.

Department of Pathology, Virginia Commonwealth University, Richmond, Virginia.

One of the traits most consistently seen in females with Turner syndrome is premature ovarian insufficiency (POI). The biological mechanisms underlying the germ cell atresia that leads to infertility in most women with Turner syndrome are unclear. Given that telomeres are important for proper chromosomal pairing and other early steps in meiosis and oogenesis, one can conjecture that perturbations in telomere length and/or function might contribute to the POI associated with Turner syndrome. Read More

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http://dx.doi.org/10.1002/ajmg.c.31684DOI Listing
February 2019
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Overnight ovarian tissue transportation for centralized cryobanking: a feasible option.

Reprod Biomed Online 2019 Jan 19. Epub 2019 Jan 19.

University Women's Hospital Bern, Division of Gynecological Endocrinology and Reproductive Medicine, Effingerstrasse 102, Bern 3010, Switzerland.

Research Question: Is overnight transportation of ovarian tissue before cryopreservation in a centralized cryobank from the FertiPROTEKT network feasible?

Design: Data from 1810 women with cryopreserved ovarian tissue after overnight transportation from December 2000 to December 2017 were analysed with a focus on transportation, tissue activity parameters and pregnancy, and delivery rates after transplantation.

Results: A total of 92.4% of tissue samples arrived at ideal temperatures of 2-8°C, 0. Read More

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http://dx.doi.org/10.1016/j.rbmo.2019.01.006DOI Listing
January 2019
1 Read

Inflamm-Aging: A New Mechanism Affecting Premature Ovarian Insufficiency.

J Immunol Res 2019 2;2019:8069898. Epub 2019 Jan 2.

Jiangxi Medical College, Nanchang University, Nanchang, China.

The normal function of ovaries, along with the secretion of sex hormones, is among the most important endocrine factors that maintain the female sexual characteristics and promote follicular development and ovulation. Premature ovarian insufficiency (POI) is a common cause in the etiology of female infertility. It is defined as the loss of ovarian function before the age of 40. Read More

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http://dx.doi.org/10.1155/2019/8069898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334348PMC
January 2019
1 Read

The ability of an LC-MS/MS-based erythrocyte GALT enzyme assay to predict the phenotype in subjects with GALT deficiency.

Mol Genet Metab 2019 Jan 22. Epub 2019 Jan 22.

Manton Center for Orphan Disease Research, Division of Genetics and Genomics, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:

Background: GALT deficiency is a rare genetic disorder of carbohydrate metabolism. Due to the decreased activity or absence of the enzyme galactose-1-phosphate uridylyltransferase (GALT), cells from affected individuals are unable to metabolize galactose normally. Lactose consumption in the newborn period could potentially lead to a lethal disease process with multi-organ involvement. Read More

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http://dx.doi.org/10.1016/j.ymgme.2019.01.016DOI Listing
January 2019
1 Read

Ovarian function after allogeneic hematopoietic stem cell transplantation in children and young adults given 8-Gy total body irradiation-based reduced-toxicity myeloablative conditioning.

Pediatr Transplant 2019 Feb 3:e13372. Epub 2019 Feb 3.

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.

Background: The spectrum of late sequelae after hematopoietic stem cell transplantation (HSCT) includes infertility, which is the most frequent complication. Some reports suggested that ovarian function may be better preserved in females undergoing HSCT with reduced-intensity conditioning (RIC) than with conventional myeloablative conditioning (MAC). However, the impact of HSCT after 8-Gy TBI-based reduced-toxicity MAC (RTMAC), whose efficacy is between those of conventional MAC and RIC, on ovarian function remains unclear. Read More

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http://dx.doi.org/10.1111/petr.13372DOI Listing
February 2019
1 Read

Does theFMR1 gene affect IVF success?

Reprod Biomed Online 2018 Dec 10. Epub 2018 Dec 10.

AdvaGenix, Rockville MD, USA.

FMR1 CGG trinucleotide repeat expansions are associated with Fragile X syndrome (full mutations) and primary ovarian insufficiency (premutation range); the effect of FMR1 on the success of fertility treatment is unclear. The effect of FMR1 CGG repeat lengths on IVF outcomes after ovarian stimulation was reviewed. PubMed was searched for studies on IVF-related outcomes reported by FMR1 trinucleotide repeat length published between 2002 and December 2017. Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.11.009DOI Listing
December 2018
1 Read

The first report showing de novo partial 21q monosomy in an adult woman with occult primary ovarian insufficiency (POI).

Clin Chem Lab Med 2019 Feb 4. Epub 2019 Feb 4.

Center for Molecular Diagnosis of Genetic Diseases, Dongfang Hospital, Xiamen University Medical College, 156 Xi'erhuanbei Road, Fuzhou City, Fujian Province 350025, P.R. China, Phone/Fax: +8659183721105.

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http://dx.doi.org/10.1515/cclm-2018-1271DOI Listing
February 2019
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Variation analysis of theTMEM150B gene in Chinese women with premature ovarian insufficiency.

Reprod Biomed Online 2018 Dec 21. Epub 2018 Dec 21.

Centre for Reproductive Medicine, Shandong University, National Research Centre for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan 250021, China.

Research Question: The TMEM150B gene, which promotes cell survival under stress conditions by modulating autophagy, is closely associated with age at natural menopause, early menopause and premature ovarian insufficiency (POI) in European women. However, whether gene variants of TMEM150B contribute to the pathogenesis of POI needs to be determined.

Design: A case-control genetic study in 408 Han Chinese women with non-syndromic POI, in which all exons and exon-intron boundaries of the TMEM150B gene were screened by Sanger sequencing; the results were analysed by statistics and bioinformatics. Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.12.009DOI Listing
December 2018
2 Reads

Association between premature ovarian insufficiency, early menopause, socioeconomic status in a nationally representative sample from Korea.

Maturitas 2019 Mar 5;121:22-27. Epub 2018 Dec 5.

Department of Occupational and Environmental Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Electronic address:

Objective: We investigated whether, in the Korean population, the risk of premature ovarian insufficiency (POI) and early menopause varies with a woman's socioeconomic status, evaluated in relation to income, education, and occupation.

Methods: This cross-sectional, population-based study involved 31,508 women aged >19 years registered in the Korea National Health and Nutrition Examination Survey (KNHANES) (2007-2016). Menopausal status and socioeconomic status were obtained from self-reported KNHANES data. Read More

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http://dx.doi.org/10.1016/j.maturitas.2018.12.004DOI Listing
March 2019
1 Read

Novel inactivating mutations in the FSH receptor cause premature ovarian insufficiency with resistant ovary syndrome.

Reprod Biomed Online 2018 Dec 8. Epub 2018 Dec 8.

Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, People's Republic of China; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, Hunan 410078, People's Republic of China; NHC Key Laboratory of human stem cell and reproductive engineering, Changsha, Hunan 410078, People's Republic of China. Electronic address:

Research Question: What is the genetic aetiology of three resistant ovary syndrome (ROS) pedigrees from 13 Chinese Han families with non-syndromic premature ovarian insufficiency (POI).

Design: The proband in each family was subjected to whole-exome sequencing. Bioinformatic and in-vitro functional analyses were performed for the functional characterization of the FSHR mutations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14726483183059
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http://dx.doi.org/10.1016/j.rbmo.2018.11.011DOI Listing
December 2018
4 Reads

Dual oocyte retrieval and embryo transfer in the same cycle for women with premature ovarian insufficiency.

Int J Gynaecol Obstet 2019 Jan 28. Epub 2019 Jan 28.

Research Institute, McGill University Health Care Center, Montreal, QC, Canada.

Objective: To compare dual oocyte retrieval with minimal ovarian stimulation and embryo transfer in the same menstrual cycle versus conventional ovarian stimulation among women with premature ovarian insufficiency (POI).

Methods: A retrospective study of 51 women with POI attending a reproductive center in Turkey between 2013 and 2015. Women with an ovarian follicle of 12 mm or larger early in the follicular phase who underwent oocyte retrieval followed by an immediate cycle of ovarian stimulation (group 1, n=14) were compared with those who received conventional ovarian stimulation (group 2, n=37). Read More

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http://dx.doi.org/10.1002/ijgo.12768DOI Listing
January 2019
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High-resolution array-CGH analysis on 46,XX patients affected by early onset primary ovarian insufficiency discloses new genes involved in ovarian function.

Hum Reprod 2019 Jan 28. Epub 2019 Jan 28.

Istituto Auxologico Italiano, IRCCS, Lab of Medical Cytogenetics and Molecular Genetics, Milan, Italy.

Study Question: Can high resolution array-CGH analysis on a cohort of women showing a primary ovarian insufficiency (POI) phenotype in young age identify copy number variants (CNVs) with a deleterious effect on ovarian function?

Summary Answer: This approach has proved effective to clarify the role of CNVs in POI pathogenesis and to better unveil both novel candidate genes and pathogenic mechanisms.

What Is Known Already: POI describes the progression toward the cessation of ovarian function before the age of 40 years. Genetic causes are highly heterogeneous and despite several genes being associated with ovarian failure, most of genetic basis of POI still needs to be elucidated. Read More

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http://dx.doi.org/10.1093/humrep/dey389DOI Listing
January 2019
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[Diagnostic value of imaging (ultrasonography, doppler, CT, MR, PET-CT) for the diagnosis of a suspicious ovarian mass and staging of ovarian, tubal or primary peritoneal cancer: Article drafted from the French Guidelines in oncology entitled "Initial management of patients with epithelial ovarian cancer" developed by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY under the aegis of CNGOF and endorsed by INCa].

Gynecol Obstet Fertil Senol 2019 Jan 24. Epub 2019 Jan 24.

Service de radiologie, université Paris Descartes Sorbonne Paris Cité, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes Sorbonne Paris Cité, Inserm UMR-S970, Cardiovascular Research Center - PARCC, 56, rue Leblanc, 75015 Paris, France.

Transvaginal ultrasound is the first-line examination allowing characterizing 80 to 90% of adnexal masses (LP1). If performed by an expert, a subjective analysis is optimal. If performed by a non-expert, combining the use of Simple Rules with subjective analysis can achieve the diagnostic performance of an expert (LP1). Read More

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http://dx.doi.org/10.1016/j.gofs.2018.12.012DOI Listing
January 2019
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Human amnion-derived mesenchymal stem cell (hAD-MSC) transplantation improves ovarian function in rats with premature ovarian insufficiency (POI) at least partly through a paracrine mechanism.

Stem Cell Res Ther 2019 Jan 25;10(1):46. Epub 2019 Jan 25.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, No. 76, Linjiang Road, Chongqing, 400010, China.

Background: Chemotherapy can induce premature ovarian insufficiency (POI) and reduce fertility in young female patients. Currently, there is no effective therapy for POI. Human amnion-derived mesenchymal stem cells (hAD-MSCs) may be a promising seed cell for regenerative medicine. Read More

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http://dx.doi.org/10.1186/s13287-019-1136-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347748PMC
January 2019
3 Reads

Patterns of Referral for Fertility Preservation Among Female Adolescents and Young Adults with Breast Cancer: A Population-Based Study.

J Adolesc Young Adult Oncol 2019 Jan 24. Epub 2019 Jan 24.

1 Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Queen's University, Kingston, Canada.

Purpose: To assess the fertility preservation (FP) referral rates and patterns of newly diagnosed breast cancer in female adolescent and young adult (AYA) patients.

Methods: Women aged 15-39 years with newly diagnosed breast cancer in Ontario from 2000 to 2017 were identified using the Ontario Cancer Registry. Exclusion criteria included prior sterilizing procedure, health insurance ineligibility, and prior infertility or cancer diagnosis. Read More

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http://dx.doi.org/10.1089/jayao.2018.0102DOI Listing
January 2019
2 Reads

Ovarian tissue cryopreservation for patients with premature ovary insufficiency caused by cancer treatment: optimal protocol.

Climacteric 2019 Jan 24:1-7. Epub 2019 Jan 24.

a Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital , Capital Medical University , Beijing , China.

Objective: Premature ovary insufficiency is frequent after chemotherapy/radiotherapy in cancer patients. Ovarian tissue (OT) cryopreservation and later retransplantation, the routine method in Europe, has recently been implemented at the first center in China. We investigated the protective effect of the antioxidant N-acetyl-l-cysteine (NAC) during the decisive freezing-thawing steps. Read More

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http://dx.doi.org/10.1080/13697137.2018.1554644DOI Listing
January 2019
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Establishment of Effective Mouse Model of Premature Ovarian Failure Considering Treatment Duration of Anticancer Drugs and Natural Recovery Time.

J Menopausal Med 2018 Dec 31;24(3):196-203. Epub 2018 Dec 31.

Department of Obstetrics and Gynecology, Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.

Objectives: This study was aimed to establish the most effective premature ovarian failure (POF) mouse model using Cyclophosphamide (CTX), busulfan (Bu), and cisplatin considering treatment duration of anticancer drugs and natural recovery time.

Methods: POF was induced by intraperitoneally injecting CTX (120 mg/kg)/Bu (12 mg/kg) for 1 to 4 weeks or cisplatin (2 mg/kg) for 3 to 14 days to C57BL/6 female mice aged 6 to 8 weeks. Controls were injected with equal volume of saline for the same periods. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.6118/jmm.2018.24
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http://dx.doi.org/10.6118/jmm.2018.24.3.196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336561PMC
December 2018
6 Reads

Umbilical Cord Blood Mesenchymal Stem Cells as an Infertility Treatment for Chemotherapy Induced Premature Ovarian Insufficiency.

Biomedicines 2019 Jan 18;7(1). Epub 2019 Jan 18.

Department of Obstetrics and Gynecology, University of Illinois, Chicago, IL 60612, USA.

Background: Premature ovarian insufficiency (POI) is a challenging disease, with limited treatment options at the moment. Umbilical cord blood mesenchymal stem cells (UCMSCs) have demonstrated promising regenerative abilities in several diseases including POI.

Materials And Method: A pre-clinical murine case versus vehicle control randomized study. Read More

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http://dx.doi.org/10.3390/biomedicines7010007DOI Listing
January 2019
1 Read

Adrenarche and pubarche in girls with turner syndrome during growth-promoting therapy with human growth hormone.

BMC Endocr Disord 2019 Jan 18;19(1). Epub 2019 Jan 18.

Paediatric Endocrinology, University Hospital of Erlangen, Loschgestr. 15, 91054, Erlangen, Germany.

Background: Data on adrenarche and pubarche in girls with Turner syndrome (TS) are inconsistent in the literature.

Methods: The cohort consisted of 94 girls and young women with TS born between 1971 and 2001 (age range: 3.1-23. Read More

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http://dx.doi.org/10.1186/s12902-019-0333-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339350PMC
January 2019
2 Reads

Serum levels of phthalates and bisphenol-A in patients with primary ovarian insufficiency.

Gynecol Endocrinol 2019 Jan 13:1-4. Epub 2019 Jan 13.

a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Talatpasa Bulvari , Ankara , Turkey.

Objectives: Phthalates and bisphenol-A (BPA) may pose a risk for human reproduction. Adverse effects of endocrine disturbing chemicals on animal ovaries have been proposed previously. This study was designed to measure the concentrations of phthalate diesters or their metabolites in serum to evaluate their relevance with primary ovarian insufficiency (POI). Read More

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https://www.tandfonline.com/doi/full/10.1080/09513590.2018.1
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http://dx.doi.org/10.1080/09513590.2018.1534951DOI Listing
January 2019
5 Reads

Concordance of Fingerstick and Venipuncture Sampling for Fertility Hormones.

Obstet Gynecol 2019 Feb;133(2):343-348

Modern Fertility, San Francisco, and Universal Diagnostic Laboratories, Van Nuys, California; and Rutgers-New Jersey Medical School, Newark, New Jersey.

Background: Minimally invasive fingerstick sampling allows testing of reproductive hormone levels at home, providing women with increased access to tests that can screen for conditions such as polycystic ovarian syndrome, primary ovarian insufficiency, and pituitary and thyroid dysfunction.

Method: We present a measurement procedure comparison study of matched venipuncture and fingerstick samples from 130 women aged 18-40 years, tested on menstrual cycle day 3. Samples were measured for anti-müllerian hormone, estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), testosterone, thyroid-stimulating hormone (TSH), and free thyroxine (T4) levels. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003066DOI Listing
February 2019
1 Read

Impact of uteroplacental insufficiency on ovarian follicular pool in the rat.

Reprod Biol Endocrinol 2019 Jan 10;17(1):10. Epub 2019 Jan 10.

NORDFERTIL Research Lab Stockholm, Pediatric Endocrinology Unit, Department of Women's and Children's Health, Karolinska Institutet and University Hospital, Visionsgatan 4; J9:30, SE-171 64, Solna, Stockholm, Sweden.

Background: A low oxygen supply to the fetus causes intrauterine growth restriction and can affect gonadal development of the offspring, having a potential impact on fertility. We investigated histology and gene expression in the postnatal rat ovary after fetal hypoxia induced by uterine artery ligation.

Methods: Sprague-Dawley rats underwent uterine artery ligation at day 19 of gestation. Read More

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https://rbej.biomedcentral.com/articles/10.1186/s12958-019-0
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http://dx.doi.org/10.1186/s12958-019-0453-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329190PMC
January 2019
5 Reads

Hypothalamic-Pituitary-Ovarian Axis Disorders Impacting Female Fertility.

Biomedicines 2019 Jan 4;7(1). Epub 2019 Jan 4.

Division of Reproductive Endocrinology Infertility and Genetics, Augusta University, Medical College of Georgia, Augusta, GA 30912, USA.

The hypothalamic-pituitary-ovarian (HPO) axis is a tightly regulated system controlling female reproduction. HPO axis dysfunction leading to ovulation disorders can be classified into three categories defined by the World Health Organization (WHO). Group I ovulation disorders involve hypothalamic failure characterized as hypogonadotropic hypogonadism. Read More

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http://dx.doi.org/10.3390/biomedicines7010005DOI Listing
January 2019
2 Reads

Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.

Pathol Oncol Res 2019 Jan 8. Epub 2019 Jan 8.

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Rapid advance in oncology leads to increasing survival of oncologic patients. More and more of them live long enough to reach either the natural age of menopause or, as a side effect of their oncotherapy, experience the cessation of gonadal function, leading to premature ovarian insufficiency, with disturbing vasomotor symtoms and long-term negative cardiovascular and skeletal effects. Thus, an ever increasing number of cancer survivors search endocrinologic help in the form of hormone replacement therapy (HRT). Read More

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http://link.springer.com/10.1007/s12253-018-00569-x
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http://dx.doi.org/10.1007/s12253-018-00569-xDOI Listing
January 2019
5 Reads

Whole-exome sequencing reveals SALL4 variants in premature ovarian insufficiency: an update on genotype-phenotype correlations.

Hum Genet 2019 Jan 2;138(1):83-92. Epub 2019 Jan 2.

Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), School of Life Sciences, Fudan University, Shanghai, 200011, China.

Premature ovarian insufficiency (POI) is a severe female disorder characterized by primary or secondary amenorrhea before 40 years of age. Genetic factors have been implicated in the pathogenesis of POI, but known POI-associated genes account for only a small fraction of heritability. Here, we performed whole-exome sequencing (WES) to explore pathogenic genes in Han Chinese subjects with POI. Read More

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http://dx.doi.org/10.1007/s00439-018-1962-4DOI Listing
January 2019
2 Reads

In vitro and in vivo mouse follicle development in ovaries and reaggregated ovaries.

Reproduction 2019 Feb;157(2):135-148

Nuffield Department of Women's and Reproductive Health, University of Oxford, Women's Centre, Level 3, John Radcliffe Hospital, Oxford, United Kingdom.

Follicle development requires complex and coordinated interactions between both the oocyte and its associated somatic cells. In ovarian dysfunction, follicle development may be abnormal due to defective somatic cell function; for example, premature ovarian insufficiency or malignancies. Replacing defective somatic cells, using the reaggregated ovary (RO) technique, may 'rescue' follicle development. Read More

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http://dx.doi.org/10.1530/REP-18-0115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347279PMC
February 2019
3 Reads

Premature Ovarian Insufficiency: Procreative Management and Preventive Strategies.

Biomedicines 2018 Dec 28;7(1). Epub 2018 Dec 28.

Department of Obstetrics and Gynecology, Augusta University, Augusta, GA 30912, USA.

Premature ovarian insufficiency (POI) is the loss of normal hormonal and reproductive function of ovaries in women before age 40 as the result of premature depletion of oocytes. The incidence of POI increases with age in reproductive-aged women, and it is highest in women by the age of 40 years. Reproductive function and the ability to have children is a defining factor in quality of life for many women. Read More

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http://dx.doi.org/10.3390/biomedicines7010002DOI Listing
December 2018
1 Read

Association between tissue inhibitor of metalloproteinase (TIMP) genetic polymorphisms and primary ovarian insufficiency (POI).

Maturitas 2019 Feb 27;120:77-82. Epub 2018 Nov 27.

Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, South Korea; Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam 13496, South Korea. Electronic address:

Background: Until now, an association between tissue inhibitor of metalloproteinase (TIMP) polymorphisms and primary ovarian insufficiency (POI) has not been identified. The aim of our study was to investigate whether the TIMP polymorphisms TIMP1T > C (rs4898), TIMP1G > A (rs6609533), TIMP2G > C (rs8179090), TIMP2G > A (rs2277698), TIMP3G > A (rs135029), and TIMP4T > C (rs3755724), which regulate matrix metalloproteinases (MMPs), confer a risk for primary ovarian insufficiency (POI) in Korean women (further studies would be required to evaluate the associations between TIMP polymorphisms and POI in other populations).

Methods: We genotyped 137 POI patients and 236 controls for the single nucleotide polymorphism sites using PCR-RFLP analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785122183046
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http://dx.doi.org/10.1016/j.maturitas.2018.11.018DOI Listing
February 2019
6 Reads

Investigating menopause in adolescent girls.

Authors:
Eleni Armeni

Case Rep Womens Health 2019 Jan 13;21:e00092. Epub 2018 Dec 13.

Second Department of Obstetrics and Gynecology, Aretaieio Hospital, National and Kapodistrian University of Athens, Athens GR-11528, Greece.

•Menstrual irregularities in adolescents might rarely be attributed to primary ovarian insufficiency (POI).•Investigation involves genetic screen, karyotyping, autoimmune screen, metabolic screen and exclusion of viral infections.•POI has significant implications for the future cardiovascular and bone health as well as for fertility. Read More

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http://dx.doi.org/10.1016/j.crwh.2018.e00092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302242PMC
January 2019
1 Read

Human Menstrual Blood-Derived Stromal Cells Promote Recovery of Premature Ovarian Insufficiency Via Regulating the ECM-Dependent FAK/AKT Signaling.

Stem Cell Rev 2018 Dec 17. Epub 2018 Dec 17.

Department of Obstetrics and Gynecology-Reproductive Medical Center of Shengjing Hospital Affiliated to China Medical University, Shenyang, China.

POI is characterized by "absent not abnormal" menstruation with hormonal disorders in woman younger than 40 years of age, and etiological and pathophysiological mechanisms underlying the POI development have not been clearly defined. Recently, due to advantages such as abundant sources and non-invasive methods of harvest, MenSCs have been emerging as a promising treatment strategy for the recovery of female reproductive damage. Here, we demonstrated that MenSCs graft in POI mice after CTX treatment could restore ovarian function by regulating normal follicle development and estrous cycle, reducing apoptosis in ovaries to maintain homeostasis of microenvironment and modulating serum sex hormones to a relatively normal status. Read More

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http://link.springer.com/10.1007/s12015-018-9867-0
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http://dx.doi.org/10.1007/s12015-018-9867-0DOI Listing
December 2018
8 Reads

Anti-müllerian hormone compared with other ovarian markers after childhood cancer treatment.

Acta Oncol 2018 Dec 18:1-7. Epub 2018 Dec 18.

a Department of Clinical Sciences Lund, Pediatrics, Pediatric Endocrinology , Lund University, Skane University Hospital , Lund , Sweden.

Background: Gonadal dysfunction is one of the major late complications after cancer diagnosis and treatment. The best markers of ovarian reserve in clinical practice are antral follicle count (AFC) and ovarian volume. We aimed to study the prevalence of premature ovarian insufficiency (POI) and evaluate anti-Müllerian hormone (AMH) and other serum markers for ovarian function in adult women who were childhood cancer survivors (CCS) in comparison with a control group. Read More

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https://www.tandfonline.com/doi/full/10.1080/0284186X.2018.1
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http://dx.doi.org/10.1080/0284186X.2018.1529423DOI Listing
December 2018
10 Reads

Radiations and female fertility.

Reprod Biol Endocrinol 2018 Dec 16;16(1):112. Epub 2018 Dec 16.

Department of Medical and Surgical Sciences and Translational Medicine, Sant'Andrea Hospital, Faculty of Medicine and Psychology, University of Rome "Sapienza", Rome, Italy.

Hundreds of thousands of young women are diagnosed with cancer each year, and due to recent advances in screening programs, diagnostic methods and treatment options, survival rates have significantly improved. Radiation therapy plays an important role in cancer treatment and in some cases it constitutes the first therapy proposed to the patient. However, ionizing radiations have a gonadotoxic action with long-term effects that include ovarian insufficiency, pubertal arrest and subsequent infertility. Read More

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https://rbej.biomedcentral.com/articles/10.1186/s12958-018-0
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http://dx.doi.org/10.1186/s12958-018-0432-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295315PMC
December 2018
9 Reads
2.409 Impact Factor

Fragile X Associated Primary Ovarian Insufficiency (FXPOI): Case Report and Literature Review.

Front Genet 2018 27;9:529. Epub 2018 Nov 27.

Sheba Medical Center, Tel Hashomer and Tel Aviv University, Tel Aviv, Israel.

Abnormalities in the X-linked gene are associated with a constellation of disorders, which have broad and profound implications for the person first diagnosed, and extended family members of all ages. The rare and pleiotropic nature of the associated disorders, both common and not, place great burdens on (1) the affected families, (2) their care providers and clinicians, and (3) investigators striving to conduct research on the conditions. Fragile X syndrome, occurring more severely in males, is the leading genetic cause of intellectual disability. Read More

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http://dx.doi.org/10.3389/fgene.2018.00529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278244PMC
November 2018
1 Read

Resumption of Ovarian Function After Ovarian Biopsy/Scratch in Patients With Premature Ovarian Insufficiency.

Reprod Sci 2018 Dec 12:1933719118818906. Epub 2018 Dec 12.

1 Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China.

To evaluate the effect of ovarian biopsy and scratch on the resumption of ovarian function in women with premature ovarian insufficiency (POI), the follicle development and pregnancy outcome were retrospectively analyzed in women with POI after ovarian biopsy/scratch. Eighty patients with POI with secondary amenorrhea were accepted the laparoscopic surgery, and then hormone replacement treatment for 6 months was applied and in vitro fertilization and embryo transfer was suggested. No significant difference in clinical characteristics was observed before and after ovarian biopsy/scratch ( P > . Read More

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http://dx.doi.org/10.1177/1933719118818906DOI Listing
December 2018
2 Reads

Establishment of a Mouse Model of Premature Ovarian Failure Using Consecutive Superovulation.

Cell Physiol Biochem 2018 7;51(5):2341-2358. Epub 2018 Dec 7.

Key Laboratory of the Model Animal Research, Animal Core Facility of Nanjing Medical University, Nanjing Medical University, Nanjing,

Background/aims: This study investigated the effect of consecutive superovulation on the ovaries and established a premature ovarian failure (POF) model in mice.

Methods: The mouse POF model was induced by 5-15 consecutive superovulation treatments with pregnant mare serum gonadotropin (PMSG), human chorionic gonadotropin (HCG) and prostaglandin F2α (PGF2α). Normal adult mice were compared with mice displaying natural ovarian aging. Read More

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http://dx.doi.org/10.1159/000495895DOI Listing
January 2019
21 Reads

Inhibitors of apoptosis protect the ovarian reserve from cyclophosphamide.

J Endocrinol 2019 Feb;240(2):243-256

Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Cancer therapy can cause off-target effects including ovarian damage, which may result in primary ovarian insufficiency in girls and premenopausal women. Loss of ovarian follicles within the ovarian reserve leads to ovarian endocrine dysfunction and impaired fertility. Cyclophosphamide (CPA), a commonly used chemotherapeutic and immunosuppressant agent, is a gonadotoxic agent that destroys ovarian cells by crosslinking DNA. Read More

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http://dx.doi.org/10.1530/JOE-18-0370DOI Listing
February 2019
2 Reads

Ovarian protection with gonadotropin-releasing hormone agonists during chemotherapy in cancer patients: From biological evidence to clinical application.

Cancer Treat Rev 2019 Jan 1;72:65-77. Epub 2018 Dec 1.

Fertility Clinic, CUB-Hôpital Erasme and Research Laboratory on Human Reproduction, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium.

Survivorship issues are an area of crucial importance to be addressed as early as possible by all health care providers dealing with cancer patients. In women diagnosed during their reproductive years, the possible occurrence of chemotherapy-induced premature ovarian insufficiency (POI) is of particular concern being associated with important menopause-related symptoms, psychosocial issues as well as infertility. Temporary ovarian suppression by administering a gonadotropin-releasing hormone agonist (GnRHa) during chemotherapy has been studied to reduce the gonadotoxic impact of chemotherapy thus diminishing the chance of developing POI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03057372183019
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http://dx.doi.org/10.1016/j.ctrv.2018.11.006DOI Listing
January 2019
3 Reads

Electro-acupuncture attenuates the mice premature ovarian failure via mediating PI3K/AKT/mTOR pathway.

Life Sci 2019 Jan 3;217:169-175. Epub 2018 Dec 3.

College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:

Aims: Electro-acupuncture (EA) is frequently recommended as a complementary therapy for premature ovarian failure (POF) in the clinical. However, little information exists about its potential treatment mechanisms. The study was designed to observe the effect of EA to ovarian function and fertility in POF mice model, and investigated its potential mechanisms on PI3K/AKT/mTOR signaling pathway. Read More

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http://dx.doi.org/10.1016/j.lfs.2018.11.059DOI Listing
January 2019
3 Reads

Resolution of primary ovarian insufficiency after corticosteroid administration in a myasthenia gravis patient: Report and minireview of the literature.

Neurol India 2018 Nov-Dec;66(6):1807-1810

Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.4103/0028-3886.246274DOI Listing
December 2018
1 Read

Constitutional chromosome rearrangements that mimic the 2017 world health organization "acute myeloid leukemia with recurrent genetic abnormalities": A study of three cases and review of the literature.

Cancer Genet 2019 Jan 20;230:37-46. Epub 2018 Nov 20.

Department of Laboratory Medicine and Pathology, Division of Laboratory Genetics and Genomics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States.

Objectives: To identify and characterize constitutional chromosomal rearrangements that mimic recurrent genetic abnormalities in acute myeloid leukemia (AML).

Methods: Bone marrow and blood chromosome studies were reviewed to identify constitutional rearrangements that resemble those designated by the 2017 revised World Health Organization (WHO) "AML with recurrent genetic abnormalities". Mate-pair sequencing (MPseq) was performed on cases with constitutional chromosome mimics of recurrent AML abnormalities to further define the rearrangement breakpoints. Read More

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http://dx.doi.org/10.1016/j.cancergen.2018.11.005DOI Listing
January 2019
10 Reads

XRCC2 mutation causes premature ovarian insufficiency as well as non-obstructive azoospermia in humans.

Clin Genet 2018 Nov 29. Epub 2018 Nov 29.

Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, Hunan , China.

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http://dx.doi.org/10.1111/cge.13475DOI Listing
November 2018
3 Reads

Prevalence of Stress Urinary Incontinence in Women with Premature Ovarian Insufficiency.

J Womens Health (Larchmt) 2018 Nov 28. Epub 2018 Nov 28.

State Key Laboratory of Reproductive Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University/Jiangsu Province Hospital, Nanjing Medical University , Nanjing, China .

Background: To determine the prevalence of stress urinary incontinence (SUI) and associated factors in women with premature ovarian insufficiency (POI).

Materials And Methods: The study included 149 patients with POI and 303 control women without POI. Age, body mass index (BMI), gestational history, time since onset of POI, and status of hormone therapy (HT) for POI were recorded. Read More

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http://dx.doi.org/10.1089/jwh.2018.6935DOI Listing
November 2018
6 Reads

Pubertal Development and Pregnancy Outcomes in 46,XX Patients with Nonclassic Lipoid Congenital Adrenal Hyperplasia.

J Clin Endocrinol Metab 2018 Nov 23. Epub 2018 Nov 23.

Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.

Context: Lipoid congenital adrenal hyperplasia (LCAH) is characterized by a disorder of steroidogenesis in both adrenal glands and gonads. 46,XX patients with classic LCAH usually have thelarche and menarche, but show anovulatory menstruations and subsequent premature menopause. Only three patients with classic LCAH have been reported to successfully achieve delivery with the aid of assisted reproductive therapies for conception and progesterone replacement therapy during early pregnancy. Read More

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http://dx.doi.org/10.1210/jc.2018-01752DOI Listing
November 2018
1 Read

Bi-allelic recessive loss-of-function mutations in FIGLA cause premature ovarian insufficiency with short stature.

Clin Genet 2018 Nov 25. Epub 2018 Nov 25.

IVF Center, Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Premature ovarian insufficiency (POI) is a group of heterogeneous disorders characterized by decreased ovarian reserve and increased follicle stimulating hormone (FSH) levels. It is rarely associated with short stature. FIGLA mutations with POI are identified with regard to heterozygosity; till date, only one affected family has been identified with homozygous mutations in FIGLA but without functional evaluation. Read More

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http://dx.doi.org/10.1111/cge.13486DOI Listing
November 2018
2 Reads

Identifying the need to refine the potential patient risk factors for niraparib-induced thrombocytopenia.

Gynecol Oncol 2019 02 20;152(2):265-269. Epub 2018 Nov 20.

Department of Obstetrics, Gynecology and Reproductive Sciences, UTHealth McGovern Medical School, Houston, TX, United States of America.

Objective: Niraparib is a poly (ADP-ribose) polymerase inhibitor (PARP) approved for use in maintenance therapy for ovarian cancer that is associated with the unpredictable grade 3/4 thrombocytopenia. This study was conducted to refine patient dosing recommendations for niraparib based upon clinical practice observations of grade 3/4 thrombocytopenia.

Methods And Materials: Six patient cases were reviewed to identify similarities in patient factors. Read More

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http://dx.doi.org/10.1016/j.ygyno.2018.11.024DOI Listing
February 2019
2 Reads

Loss-of-function mutations with circadian rhythm regulator Per1/Per2 lead to premature ovarian insufficiency.

Biol Reprod 2018 Nov 18. Epub 2018 Nov 18.

Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, China.

Mechanism underlying premature ovarian insufficiency remains incompletely understood. Here we report that mice with Per1m/m; Per2m/m double mutations display a decrease in female fertility starting approximately at 20-week-old, with significantly less pups born from 32-week-old onwards. Histological analysis revealed that a significant reduction of ovarian follicles was observed in the Per1/Per2 mutants compared with the littermate controls examined at 26- and 52-week-old while the difference was not statistically significant between the two groups at 3- and 8-week-old. Read More

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http://dx.doi.org/10.1093/biolre/ioy245DOI Listing
November 2018
11 Reads
3.320 Impact Factor

25(OH)D serum concentration in women with menstrual disorders -risk factors for Vitamin D deficiency.

Neuro Endocrinol Lett 2018 Sep;39(3):219-225

1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland, Pl. Starynkiewicza 1-3, 02-015 Warsaw, Poland.

Introduction: Vitamin D (VD) plays a crucial role in calcium metabolism as well as immunological and endocrine homeostasis. Previous studies revealed strong inverse correlation between VD levels and insulin resistance, parathyroid dysfunctions and autoimmune thyroid disease. Insufficient evidence concerns its dependency of ovarian hormones. Read More

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September 2018
9 Reads