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Semin Diagn Pathol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.

Approximately 5% of gynecological malignancies are associated with paraneoplastic hypercalcemia. Awareness of its association with certain tumor types allows for earlier disease detection and facilitates monitoring of treatment response and disease recurrence. We review the salient clinicopathological features, differential diagnosis and management issues in some of these gynecological tumors, namely: small cell carcinoma, hypercalcemic type; ovarian clear cell carcinoma, dysgerminoma and juvenile granulosa cell tumors. Read More

South Asian J Cancer 2019 Jan-Mar;8(1):35-40

Department of Biostatistics, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India.

Objective: The objective of this study is to evaluate the pattern of care and survival outcome in patients with malignant ovarian germ cell tumors (MOGCTs).

Materials And Methods: Between January 2004 and August 2017, 50 patients with MOGCT were identified at Amrita Institute of Medical Sciences and 48 included in analyses. Histologic subtypes were as follows: dysgerminoma 11; immature teratoma 16; yolk sac tumor 3; and mixed germ cell tumor 18. Read More

Int J Gynecol Cancer 2019 Jan 29. Epub 2019 Jan 29.

Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York City, New York, USA.

Objective: To investigate the prognostic significance of complete gross resection following cytoreductive surgery for patients with advanced stage malignant ovarian germ cell tumors.

Methods: The National Cancer Data Base was accessed and patients diagnosed with an advanced stage (II-IV) malignant ovarian germ cell tumor who underwent primary cytoreductive surgery between 2011 and 2014 were selected for further analysis. For analysis purposes two groups were formed: patients with complete gross resection and those with macroscopic residual disease. Read More

Int J Gynecol Cancer 2019 Jan 23. Epub 2019 Jan 23.

Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China

Objective: To evaluate the role of omentectomy and lymphadenectomy in the treatment of clinically apparent early-stage malignant ovarian germ cell tumors.

Methods: We retrospectively reviewed 245 patients with malignant ovarian germ cell tumors (yolk sac tumor, dysgerminoma, and immature teratoma) and with clinically early-stage disease, who were treated at Sun Yat-sen University Cancer Center between January 1, 1970 and December 31, 2017. The survival of patients who underwent either omentectomy or lymphadenectomy, or both (omentectomy/lymphadenectomy group) was compared with that of patients who did not undergo omentectomy or lymphadenectomy (non-omentectomy/lymphadenectomy group). Read More

Comb Chem High Throughput Screen 2018 ;21(9):652-661

Department of Gynecology and Obstetrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Background: Lymphadenectomy has been widely used in the treatment of malignant germ cell tumor of the ovary (OGCT), which is a kind of ovarian cancers occurred mostly in young women and adolescent girls. But the clinical decision mainly depends on the doctor's experience without a well-defined guideline. This population-based study aimed to evaluate the prognostic impact of lymphadenectomy in different stages of malignant germ cell tumors of the ovary. Read More

J Obstet Gynaecol Can 2018 Dec 12. Epub 2018 Dec 12.

Department of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, MB.

Objective: To discuss the finding of hypercalcemia in pediatric ovarian dysgerminoma.

Methods: Two cases of pediatric ovarian dysgerminoma that presented with hypercalcemia are discussed.

Results: Hypercalcemia is a rare finding in ovarian dysgerminoma. Read More

Taiwan J Obstet Gynecol 2018 Dec;57(6):871-877

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Objective: The coexistence of maternal malignancy and pregnancy has received increasing attention in Noninvasive prenatal testing (NIPT) studies. Malignancy in pregnant women potentially affects the copy number variation (CNV) profile in NIPT results. Only one case of hematologic cancer has been reported in a Hong-Kong pregnant women, and solid tumors have never been reported in pregnant Chinese women. Read More

Int J Gynecol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Departments of Obstetrics and Gynecology (N.I., Y.F., T.S., A.K., T.O., F.K.) Pathology (Y. Ikura, Y. Iwai) Hematology (M.O.), Takatsuki General Hospital, Takatsuki, Japan.

Primary ovarian lymphomas are rare, but can potentially evoke diagnostic problems. We present a case of ovarian lymphoma, in which an ambiguous intraoperative pathologic report led to overtreatment (unnecessary surgery). A 73-yr-old woman with fatigue and low-grade fever was diagnosed as having a left ovarian tumor by imaging modalities. Read More

Int J Surg Pathol 2018 Nov 25:1066896918813658. Epub 2018 Nov 25.

1 Rutgers-New Jersey Medical School, Newark, NJ, USA.

Primary lymphoma of the ovary, particularly in an HIV-positive woman, is exceptionally rare, and ovarian lymphoma may not be considered at the time of intraoperative consultation. In this article, we present a case in an HIV-positive woman thought to be a dysgerminoma at the time of frozen section, but which was found to be a diffuse large B-cell lymphoma of the ovary. Read More

Pediatr Int 2018 Oct;60(10):982-983

Department of Pediatrics, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Ann Med Surg (Lond) 2018 Sep 21;33:50-52. Epub 2018 Aug 21.

Faculdade de Medicina (FAMED) - Universidade Federal do Rio Grande (FURG), Rio Grande city, Rio Grande do Sul State, Brazil.

Introduction: Malignant ovarian germ cell tumors (MOGCTs) are rare malignancies with an incidence of about 0.5/100,000. They account for less than 5% of all ovarian tumors, of which 32. Read More

Gynecol Oncol 2018 10 28;151(1):61-68. Epub 2018 Aug 28.

Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; Division of Gynaecological Oncology, Leuven Cancer Institute, Kuleuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

Background: Ovarian germ cell tumors (OGCT) are rare gynecological neoplasms, mostly affecting children and young women. The underlying molecular genetic background of these tumors is poorly characterized.

Methods: We analyzed somatic copy number aberration (CNA) profiles in 87 OGCT tumors and performed whole exome sequencing (WES) on 24 OGCT tumor and matched germline samples to further elucidate their molecular genetic landscape. Read More

J Neurol 2018 Jul 12. Epub 2018 Jul 12.

French Reference Center for Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hôpital Neurologique, 69677, Bron, France.

Objective: The aim of this study was to describe specificities of patients with NMDA receptor antibody (NMDAR-Ab) encephalitis associated with a malignant tumor.

Methods: Retrospective observational study of 252 patients with NMDAR-Ab encephalitis of the French Paraneoplastic Neurological Syndrome Reference Center. Patients were classified in three groups: (1) non-malignant ovarian teratomas, (2) malignant ovarian teratomas (immature), and (3) other malignant tumors. Read More

Zhonghua Bing Li Xue Za Zhi 2018 Jul;47(7):531-535

Department of Pediatric Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.

To investigate the pathologic features of gonadal tissues of disorders of sexual development (DSD) in children. Fifty-three cases of gonadal developmental disorders were collected from July 2015 to August 2017 at Guangzhou Women and Children's Medical Center. Clinical manifestations, karyotypes, sex hormone levels, ultrasound imaging, histology and immunophenotype of gonadal tissues were analyzed. Read More

Cureus 2018 Apr 23;10(4):e2522. Epub 2018 Apr 23.

Department of Pathology & Laboratory Medicine, The Aga Khan University, Karachi, PAK.

Dysgerminomas are malignant germ cell tumors of the ovary that most commonly occur in the adolescent population. Ovarian dysgerminoma presenting with complications like torsion is a rare entity in the pediatric age group. Cross-sectional imaging plays a crucial role in diagnosis, tumor staging before surgical resection, and for planning adjuvant chemotherapy. Read More

Indian J Surg Oncol 2018 Jun 10;9(2):215-219. Epub 2018 Apr 10.

1Department of Surgical Oncology, King George's Medical University, Lucknow, Uttar Pradesh 226003 India.

Malignant germ cell tumors (GCT) of the ovary account for 2-3% of all ovarian neoplasms and occur mostly in the second and third decade of life. Over the past three decades, survival rates for germ cell tumors have dramatically improved, coincident with more aggressive surgical staging and combination chemotherapy. Although there are several studies describing ovarian GCT and fertility-preserving surgery in the western population, there is very little Indian data. Read More

Gynecol Oncol 2018 08 5;150(2):253-260. Epub 2018 Jun 5.

Children's and Young Persons Cancer Services, University College London Hospital Trusts, London, UK.

Objective: Dysgerminoma is the most common malignant ovarian germ cell tumor (GCT) with peak incidence during adolescence and young adulthood. Current standard of care for patients with disease that has spread outside of the ovary (advanced-stage) utilizes platin-based chemotherapy regimens. The study objective was to compare clinical outcomes between platin-based (carboplatin versus cisplatin) strategies across all age groups (children < 11 years (y), adolescents = 11-25 y and young adult women > 25 y) for advanced-stage dysgerminoma. Read More

PLoS One 2018 7;13(6):e0198670. Epub 2018 Jun 7.

Laboratory of Wildlife Comparative Pathology - LAPCOM, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil.

This retrospective study describes the biological and epidemiological aspects, gross and microscopical findings, and most likely causes of death (CD) in two species of Neotropical deer in Brazil. The animals were collected between 1995 and 2015 and represented 75 marsh deer (MD) and 136 brown brocket deer (BBD). Summarized, pneumonia was diagnosed microscopically in 48 MD and 52 BBD; 76 deer suffered trauma, involving dog attack (14 BBD) and vehicle-collision (14 BBD). Read More

Medicine (Baltimore) 2018 May;97(20):e10730

Department of Pathology, West China Second Hospital of Sichuan University.

Rationale: Adrenocortical carcinoma (ACC) is an endocrine malignancy with poor prognosis, which commonly arises in a sporadic manner, but may also become a part of a familial syndrome. ACC rarely arises simultaneously with other malignant tumors.

Patient Concerns: We report a case of a 29-year-old woman with ACC synchronously followed by an ovarian malignant mixed germ cell tumor. Read More

Iran J Pathol 2018 ;13(1):94-98

Dept. of Pathology, Imam Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Dysgerminoma is one of the two most common types of ovarian germ cell tumors. Providing accurate pathologic diagnosis and treatment planning, the prognosis is good even in advanced stages. Pathologic diagnosis is generally straightforward. Read More

Reprod Domest Anim 2018 Jun 30;53(3):784-792. Epub 2018 Mar 30.

Laboklin GmbH & Co.KG, Bad Kissingen, Germany.

Increased concentrations of Anti-Muellerian hormone (AMH) can indicate a granulosa cell tumour as shown in women, mares and cows. To investigate AMH to differentiate canine granulosa cell tumour from other ovarian pathologies, we evaluated the ovaries of 63 bitches. Blood serum samples were collected before surgery for AMH analysis. Read More

Cancer Biol Ther 2018 Aug 25;19(8):649-658. Epub 2018 Apr 25.

a Obstetrics and Gynecology Department , Tianjin Medical University General Hospital , No.154, Anshan Road, Heping District , Tianjin , China.

Background: Dysgerminoma is an uncommon malignant tumor arising from the germ cells of the ovary. Its association with pregnancy is extremely rare; the incidence is about 0.2-1 per 100,000 pregnancies. Read More

J Surg Res 2018 04 22;224:38-43. Epub 2017 Dec 22.

Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address:

Background: In many cancers, racial and socioeconomic disparities exist regarding the extent of surgery. For ovarian dysgerminoma, fertility-sparing (FS) surgery is recommended whenever possible. The aim of this study was to investigate rates of FS versus non-fertility-sparing (NFS) procedures for stage I ovarian dysgerminoma in adolescents and young adults (AYAs) by ethnicity/race and socioeconomic status. Read More

Abdom Radiol (NY) 2018 Jul;43(7):1515-1523

Department of Radiology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.

We report the imaging findings of three ovarian dysgerminomas that coexisted with other germ cell tumors or gonadoblastomas, focusing on the distribution of tumor nests and vascular architecture, which might provide information about the pathogenesis of dysgerminomas. In a 14-year-old female with dysgerminoma and coexisting gonadoblastomas, contrast-enhanced magnetic resonance imaging (MRI) demonstrated a solid mass in the right ovary, which presented as hyperintense lobules on diffusion-weighted imaging separated by fibrovascular septa. Some small nodules were found to exist separately from the lobules (multiplicity) and to include pathological remnants of gonadoblastoma. Read More

Eur J Cancer 2018 03 11;91:30-37. Epub 2018 Jan 11.

Gustave Roussy, Department of Pediatric Oncology, F94805 Villejuif, France; Université Paris-Saclay, Univ. Paris-Sud, CESP, INSERM, Villejuif, F-94805, France. Electronic address:

Methods: French patients (≤18years) treated for dysgerminoma between 1985 and 2005 in TGM-85, 90, 95 protocols were included. Treatment was based on primary unilateral oophorectomy followed by prophylactic lymph node irradiation (1985-1998) or a wait-and-see strategy (1998-2005) for localised completely resected tumours (pS1) or by platinum-based chemotherapy for advanced diseases.

Results: Forty-eight patients (median age 12. Read More

Rev Esp Patol 2018 Jan - Mar;51(1):61-67. Epub 2017 Mar 28.

Servicio de Anatomía Patológica, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España.

Small cell carcinoma of ovary-hypercalcemic type is an undifferentiated carcinoma. We describe two cases in women aged 32 and 29. Both presented with large masses and complete surgical extirpation was impossible. Read More

Pediatr Blood Cancer 2018 Apr 29;65(4). Epub 2017 Dec 29.

Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts.

Purpose: In this report, we characterize the timing and behavior of malignant ovarian germ cell tumors (GCTs) in pediatric patients with dysgenetic gonads compared to those with normal gonadal development.

Patients And Methods: Patients from the Children's Oncology Group AGCT0132 with malignant ovarian GCTs were included. Within this population, we sought to identify patients with gonadoblastoma, streak ovaries, or other evidence of gonadal dysgenesis (GD). Read More

Eur J Obstet Gynecol Reprod Biol 2018 01 10;220:138-139. Epub 2017 Nov 10.

Department of Biomedical Science and Human Oncology, Obstetrics and Gynecology Unit, University of Bari, Italy.

Gynecol Endocrinol 2018 Jun 31;34(6):464-466. Epub 2017 Oct 31.

a Department of Gynecologic Oncology , Osaka International Cancer Institute , Osaka , Japan.

Patients with Swyer syndrome, which is also known as 46,XY pure gonadal dysgenesis, are at an increased risk of gonadoblastoma and germ cell tumor. Prophylactic gonadectomy is recommended for these patients. We report a case of stage IIA dysgerminoma arising in a streak gonad in a patient with Swyer syndrome, which was not diagnosable preoperatively and intraoperatively. Read More

Pediatr Endocrinol Diabetes Metab 2017 ;23(1):37-41

Department of Pediatric Endocrinology and Rheumatology, 2nd Chair of Pediatrics, Medical Faculty I, Poznan University of Medical Sciences, Poland.

Turner syndrome (TS) is an inherited genetic disorder caused by numerical and/or structural chromosome X aberrations occurring at a frequency of 1:1200-1:2500 live-born girls. The most common karyotype is X chromosome monosomy (45,X) (approximately 50-60% of cases). Approximately 5-6% of patients may have abnormal Y chromosome or mosaicism characterized by the coexistence of 45,X cell line with cell line in which all or part of chromosome Y is present. Read More

Gynecol Endocrinol 2018 May 26;34(5):389-393. Epub 2017 Oct 26.

b Department of Pathology , Sri Venkateswara Institute of Medical Sciences (SVIMS) , Tirupathi , Andhra Pradesh , India.

Swyer syndrome is a pure gonadal dysgenesis associated with a 46 XY karyotype and primary amenorrhea in a phenotypic female. Individuals in this syndrome are at an increased risk for development of gonadal malignancies. Swyer syndrome (gonadal dysgenesis) running in families is rare event and few such scenarios were reported in the literature. Read More

Gynecol Oncol 2017 12 9;147(3):493-496. Epub 2017 Oct 9.

Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.

Objective: To evaluate the prevalence and safety of uterine preservation among premenopausal women diagnosed with a malignant ovarian germ-cell tumor (MOGCT) of advanced stage (stage II-IV).

Materials And Methods: The National Cancer Database was accessed and a cohort of women aged <40years, diagnosed with a MOGCT were identified. Those with stage II-IV disease who underwent cancer-directed surgery and received chemotherapy were selected for further analysis. Read More

J Clin Diagn Res 2017 Aug 1;11(8):QD12-QD13. Epub 2017 Aug 1.

Professor, Department of Obstetrics and Gynecology, General University Hospital "Attikon", University of Athens, Athens, Greece.

Yolk Sac Tumours (YSTs) of the ovary, also called Endodermal Sinus Tumours (ESTs), are the second most common Malignant Ovarian Germ Cell Tumours (MOGCTs), after dysgerminomas. YSTs occur primarily in children and young women. We present a case report of a 20-year-old woman who had been diagnosed with YST (tumour diameter of 29 cm). Read More

J Pediatr Neurosci 2017 Apr-Jun;12(2):174-176

Department of Neurosurgery, G. B. Pant Institute of Postgraduate Medical Education and Research, New Delhi, India.

Ovarian germ cell tumors (GCTs) are rare and affect mainly young girls and women. Two histological groups are distinguished: dysgerminomas and nondysgerminomatous tumors. These tumors have initial good responses to surgery and chemotherapy in 80% cases, but >75% of patients die due to complications of disease progression. Read More

J Clin Res Pediatr Endocrinol 2018 03 24;10(1):87-90. Epub 2017 Aug 24.

Mersin University Faculty of Medicine, Department of Radiology, Mersin, Turkey.

Patients with complete XY gonadal dysgenesis (GD) show a high predisposition to germ cell tumors (GCT). Patients with coexistence of GCT and GD have been reported previously. Here we present a 15-year-old girl with mixed GCT and GD who also developed an intra-abdominal synovial sarcoma one year after the treatment. Read More

Int J Gynecol Pathol 2017 Sep;36(5):466-470

Familial Breast & Ovarian Cancer Clinic (J.M.C., R.H.K.), Princess Margaret Cancer CentreDepartments of Molecular Genetics (J.M.C.)Laboratory Medicine and Pathobiology (LMP) (A.N., T.C.), Faculty of MedicineObstetrics and Gynecology (R.F.C., F.M.), Division of Reproductive SciencesMedicine (R.H.K.), Division of Medical Oncology and Hematology, University of TorontoDepartment of Pathology and Laboratory Medicine (A.N., T.C.)Lunenfeld-Tanenbaum Research Institute (R.F.C., F.M., T.C.), Mount Sinai Hospital, Toronto, ON, CanadaWilliam Beaumont School of Medicine (B.R.), Oakland University, RochesterDivision of Gynecologic Oncology (B.R.), Beaumont Health, Royal Oak, Michigan.

Gonadoblastomas are rare mixed gonadal tumors that are almost always found in individuals with 46, XY karyotype or some other form of Y chromosome mosaicism. It is extremely rare to diagnose gonadoblastoma in phenotypically normal 46, XX females. Herein, we present a 20-year-old 46, XX female diagnosed with gonadoblastoma and dysgerminoma. Read More

J Ovarian Res 2017 Jul 27;10(1):52. Epub 2017 Jul 27.

Department of Gynecology, The Obstetrics and Gynecology Hospital of Fudan University, 128 Shenyang RD, Shanghai, 200090, China.

Background: To retrospectively investigate reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST).

Methods: Data from 32 MOGCT (6 dysgerminomas, 6 yolk sac tumors, 17 immature teratomas, and 3 mixed germ cell tumors) and 9 SCST (4 granulosa cell tumors and 5 sertoli-leydig cell tumors) aged from 18 to 35, treated in the Obstetrics and Gynecology Hospital of Fudan University from October 2003 to October 2013 were collected and analyzed.

Results: Average follow up was (86. Read More

Chin Med J (Engl) 2017 08;130(15):1882-1883

Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.

APMIS 2017 Sep 6;125(9):781-786. Epub 2017 Jun 6.

Department of Pathology, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway.

The purpose of this study was to determine the expression and potential clinical role of epithelial-to-mesenchymal transition (EMT)-related factors in malignant ovarian germ cell tumors (MOGCT). Protein expression of E-cadherin, N-cadherin, P-cadherin, Zeb1, HMGA2, and vimentin by immunohistochemistry was analyzed in 42 MOGCT from patients treated in Norway during the period 1981-2001. Expression was analyzed for association with clinicopathologic parameters. Read More

Int J Gynecol Cancer 2017 09;27(7):1373-1378

Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China.

Objective: The aim of the study was to investigate whether omentectomy (OMT) is necessary in the operation for apparently early stage malignant ovarian germ cell tumors (MOGCTs).

Methods And Materials: Searching medical records database of Sun Yat-sen University Cancer Center from January 1, 1966, to November 30, 2015, patients with MOGCTs were identified and their age, year of diagnosis, tumor grade, histologic subtype, International Federation of Gynecology and Obstetrics stage, nodal findings, gross observation of omentum, and performance of OMT were assessed. Overall survivals of patients with or without OMT were compared using Kaplan-Meier survival curves. Read More

J Cytol 2017 Apr-Jun;34(2):95-100

Department of Cytology and Gynaecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Context: Peritoneal washing is performed for staging of gynecologic tumors to detect subclinical intraperitoneal metastases.

Aim: The aim of the present study was to assess the impact of SurePath™ liquid-based cytology (LBC) in peritoneal washing in various gynecological malignancies.

Settings And Design: An audit of peritoneal-fluid/washing (January 2012 to July 2013) was performed with corresponding gynecologic specimens. Read More

Pediatr Blood Cancer 2017 Nov 27;64(11). Epub 2017 Apr 27.

Hematology/Oncology Unit, A.R.N.A.S Civico Di Cristina e Benfratelli, Palermo, Italy.

Objective: Malignant ovarian germ cell tumors (MOGCT) carry an excellent prognosis, and the treatment aims to achieve results with the least possible treatment-related morbidity. The aim of this study was to assess the outcomes of pediatric patients with MOGCT.

Methods: Patients were treated according to their stage: surgery and surveillance for stage I; a modified bleomycin-etoposide-cisplatin (BEP) regimen for stages II (three cycles), III, and IV (three cycles) with surgery on residual disease. Read More

Kathmandu Univ Med J (KUMJ) 2016 Apr-Jun;14(54):153-158

Department of Pathology, Manipal Teaching Hospital, Manipal College of Medical Science, Pokhara, Nepal.

Background Ovarian cancer accounts for 6% of all cancers in females. Among cancers of female genital tract, the incidence of ovarian cancers ranks below only carcinoma of the cervix and the endometrium. Objective To find the frequency of different types of histomorphological types and their association with age, side and size distribution. Read More

BMJ Case Rep 2017 Jan 30;2017. Epub 2017 Jan 30.

Ziv Medical Center, Tzfat, Israel.

A symptom of prolonged conflict is the destruction of infrastructure and healthcare systems. While the need for acute trauma services is obvious in conflict zones, patients with chronic diseases also require care. This report describes the clinical course of a young teenage girl with a large mid pelvic tumour originating from the left ovary and reaching the umbilicus. Read More

Bratisl Lek Listy 2016 ;117(12):738-740

Dysgerminoma is the most common ovarian germ cell type ovarian tumour. Primarily, it presents in young women at reproductive age and thus, the preservation of fertility is considered to be fundamental when it is possible for these patients. In comparison to the past the restriction of the extent of the surgical procedure as well as the introduction of innovative chemotherapeutic regimens improved significantly both, the prognosis and the clinical outcomes of this rare neoplasia. Read More

J Adolesc Young Adult Oncol 2017 Jun 13;6(2):270-276. Epub 2017 Jan 13.

Department of Gynecologic Oncology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital , Ankara, Turkey .

Purpose: To validate the oncological safety of fertility preservation in malignant ovarian germ cell tumors (MOGCTs) and to define the significance of maximal cytoreduction in early stage MOGCTs.

Materials And Methods: Sixty-nine patients with stage I and II MOGCTs who underwent surgical treatment were included in the study. Fertility-sparing surgery is defined as conservative surgery and hysterectomy and contralateral salpingo-oophorectomy were defined as definitive surgery. Read More

PLoS One 2016 28;11(12):e0168484. Epub 2016 Dec 28.

Institute of Medical Genetics, Linyi People's Hospital, Shandong, China.

SRY-mutation-caused sex reversal is a rare disease and mostly associated with a de novo mutation since the patients with defective SRY is infertile. There are many reports about SRY-mutation associated 46, XY ovarian disorder of sex development (DSD), but few described their molecular mechanism. Here we report a de novo mutation 224G>T (R75M) in SRY associated with a phenotypic female, 46, XY karyotype and dysgerminoma. Read More

BMC Pediatr 2016 11 29;16(1):195. Epub 2016 Nov 29.

Human Developmental Genetics, Institut Pasteur, Paris, France.

Background: Families with 46,XY Disorders of Sex Development (DSD) have been reported, but they are considered to be exceptionally rare, with the exception of the familial forms of disorders affecting androgen synthesis or action. The families of some patients with anorchia may include individuals with 46,XY gonadal dysgenesis. We therefore analysed a large series of patients with 46,XY DSD or anorchia for the occurrence in their family of one of these phenotypes and/or ovarian insufficiency and/or infertility and/or cryptorchidism. Read More

Ann Oncol 2017 02;28(2):333-338

Department of Medicine and Health Science, University of Molise, Campobasso/Foundation, PoliclinicoUniversitario A. Gemelli, Rome, Italy.

Background: Surgery followed by platinum-based chemotherapy is the standard of care for MOGCTs, except for stage IA dysgerminoma and stage IA grade 1 immature teratoma where surveillance only is recommended. The role of adjuvant chemotherapy and surgical staging is debated.

Patients And Methods: Data from 144 patients with stage I MOGTs were collected among MITO centers (Multicenter Italian Trials in Ovarian Cancer) and analyzed. Read More

Pediatr Blood Cancer 2017 04 26;64(4). Epub 2016 Oct 26.

Department of Pediatric Hematology/Oncology, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia.

An activating point mutation of the c-KIT tyrosine kinase receptor gene, D816H, has been described in germ cell tumors (GCTs). We report an adolescent diagnosed with an ovarian mixed GCT and systemic mastocytosis with chronic myelomonocytic leukemia (SM-CMML). The teratoma and dysgerminoma differed by copy number aberrations via single nucleotide polymorphism (SNP) microarray, but were inclusive of the same c-KIT D816H point mutation (c. Read More