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Medicine (Baltimore) 2020 May;99(22):e20472

The Department of Oncology, People's Hospital of Guilin.

Introduction: True hermaphroditism is a rare and usually sporadic disorder. It is defined by the presence of both ovarian and testicular tissues together as ovotestis.

Patient Concerns: In this study, we reported a rare true hermaphroditism case with dysgerminoma. Read More

J Obstet Gynaecol Res 2020 Jun 3;46(6):945-949. Epub 2020 Apr 3.

Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, Jodhpur, India.

Tuberculosis is a disease prevalent all over the world with India contributing to a larger share. Pulmonary tuberculosis presents with generalized symptoms of malaise, low grade fever and cough. On the other hand, genital tuberculosis presents with a variety of symptoms in each age group and is often underdiagnosed and missed. Read More

Arch Gynecol Obstet 2020 Apr 20;301(4):1021-1026. Epub 2020 Mar 20.

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Objective: Due to the rarity of recurrent and persistent malignant ovarian germ cell tumors (MOGCTs), there is no standardized protocol for salvage therapy. This study aimed to investigate the outcomes and prognostic factors of patients with recurrent and persistent MOGCTs.

Methods: Clinical data for 59 patients with recurrent and persistent MOGCTs admitted to Peking Union Medical College Hospital from January 1, 2000, to April 30, 2018, were retrospectively analyzed. Read More

Int J Gynecol Cancer 2020 May 15;30(5):664-669. Epub 2020 Mar 15.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

Objective: The standard treatment for young patients with stage I malignant ovarian germ cell tumors, except stage I dysgerminoma and stage IA G1 immature teratoma, is unilateral salpingo-oophorectomy with complete staging surgery followed by platinum-based chemotherapy. However, the role of complete staging surgery and adjuvant chemotherapy remains controversial. The aim of this study was to investigate the role of complete staging surgery and adjuvant chemotherapy in patients with early-stage pure immature teratoma after fertility-sparing surgery. Read More

Cancer Manag Res 2020 24;12:1347-1354. Epub 2020 Feb 24.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Purpose: This study aimed to analyze the clinicopathological features, treatment, and feto-maternal outcomes of pregnancy complicated by malignant ovarian germ cell tumors (MOGCTs), to increase the awareness on this condition.

Patients And Methods: We retrospectively reviewed the medical records of patients diagnosed with MOGCTs during pregnancy, who were treated and followed-up at Peking Union Medical College Hospital from January 2000 to December 2017. The demographic characteristics, pathological features, treatment and prognosis were analyzed. Read More

Case Rep Pathol 2020 13;2020:4737606. Epub 2020 Feb 13.

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Miyazaki, Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.

Ovarian dysgerminoma is a rare type of germ cell tumor. The majority of patient relapses occur within 2 years of diagnosis. Here, we report the case of a 74-year-old woman with a history of ovarian dysgerminoma 39 years earlier. Read More

Gynecol Oncol 2020 Apr 31;157(1):89-93. Epub 2020 Jan 31.

Division of Gynecologic Oncology, University of Pennsylvania Health System, Philadelphia, PA, USA.

Objective: To evaluate trends in the surgical management of young women and pediatric patients with malignant ovarian germ cell tumors (MOGCTs) and associated survival outcomes.

Materials And Methods: Using the Surveillance, Epidemiology, and End Results database we identified patients under 40 years who underwent surgery between 1994 and 2014. The Joinpoint Regression Program was employed to investigate the presence of temporal trends and calculate average annual percent change (AAPC) rates. Read More

Obstet Gynecol Sci 2020 Jan 12;63(1):98-101. Epub 2019 Dec 12.

Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Müllerian anomalies are rare deformities in women, and only a few cases concerning gynecologic malignancies arising in patients with congenital uterine malformations have been reported. Herein, we present the case of a 34-year-old woman with dysgerminoma with a Müllerian anomaly (uterus didelphys). She had secondary amenorrhea, and an ovarian mass and uterus didelphys were discovered during examination. Read More

Diagn Cytopathol 2020 Apr 30;48(4):356-359. Epub 2019 Dec 30.

Division of Pathology, Faculty of Medicine, Miyazaki University Hospital, University of Miyazaki, Miyazaki, Japan.

Dysgerminoma is a rare germ cell tumor, accounting for 1% to 2% of all malignant ovarian tumors. Here, we report a case of dysgerminoma diagnosed by aspiration cytology of a cervical lymph node. A 20-year-old woman presented with an abdominal mass and left cervical swelling. Read More

Urology 2020 Mar 27;137:157-160. Epub 2019 Dec 27.

Department of Pathology, Osaka Women's and Children's Hospital, Osaka, Japan.

Objective: To describe the gonadal features of patients with 45,X/46,XY mosaicism, and to evaluate the prevalence of gonadal tumor in different phenotypes.

Materials And Methods: The medical records of consecutive patients with 45,X/46,XY karyotype or its variants who had undergone gonadal biopsy or gonadectomy at a single institute between 1996 and 2017 were retrospectively reviewed.

Results: Of 34 patients with 45,X/46,XY mosaicism, a unilateral dysgenetic testis and a contralateral streak gonad was detected in 20 patients (59%), bilateral streak gonads in 9 (26%), and bilateral dysgenetic testes in 5 (15%). Read More

Jpn J Clin Oncol 2020 Mar;50(3):282-287

Department of Gynecologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Objective: To determine the impact of lymphadenectomy (LND) on survival of clinically apparent early-stage malignant ovarian germ cell tumors (MOGCTs).

Methods: We retrospectively analyzed the survival of patients who were diagnosed with the three most common histopathology types of malignant ovarian germ cell tumors (yolk sac tumor, dysgerminoma and immature teratoma) and with clinical stage I and II disease, and treated at Sun Yat-sen University Cancer Center between 1 January 1970 and 30 September 2018.

Results: There were 227 stage I, 28 stage II and one stage IIIA cases after surgery. Read More

Histopathology 2020 Jan;76(1):25-36

Centre for Molecular Oncology, Barts Cancer Institute, Charterhouse Square, Queen Mary University of London, London, UK.

The classification of ovarian germ cell tumours has remained unchanged for many years, while there have been considerable changes in the testicular classification. In recent years there has been concern about the overtreatment of clinical stage 1 testicular germ cell tumours with increasing use of surveillance for low-risk disease. We outline here the current classification of germ cell tumours of the ovary with particular regard to treatment and outcome and highlight some areas which may cause confusion, particularly pertaining to immature teratomas and mixed germ cell tumours. Read More

Int J Gynecol Pathol 2020 Jan;39(1):79-83

Departments of Obstetrics and Gynecology (N.I., Y.F., T.S., A.K., T.O., F.K.) Pathology (Y. Ikura, Y. Iwai) Hematology (M.O.), Takatsuki General Hospital, Takatsuki, Japan.

Primary ovarian lymphomas are rare, but can potentially evoke diagnostic problems. We present a case of ovarian lymphoma, in which an ambiguous intraoperative pathologic report led to overtreatment (unnecessary surgery). A 73-yr-old woman with fatigue and low-grade fever was diagnosed as having a left ovarian tumor by imaging modalities. Read More

Clinics (Sao Paulo) 2019 11;74:e408. Epub 2019 Nov 11.

Departamento de TocoGinecologia, Universidade Federal do Parana, Curitiba, PR, BR.

This review describes the germ cell neoplasms that are malignant and most commonly associated with several types of gonadal dysgenesis. The most common neoplasm is gonadoblastoma, while others including dysgerminomas, yolk-sac tumors and teratomas are rare but can occur. The purpose of this review is to evaluate the incidences of these abnormalities and the circumstances surrounding these specific tumors. Read More

J Pediatr Adolesc Gynecol 2020 Feb 15;33(1):83-88. Epub 2019 Oct 15.

Radiology Department, Qilu Hospital of Shandong University, Jinan City, Shangdong Province, China. Electronic address:

Study Objective: To investigate the clinical features and computed tomography (CT) findings of malignant pelvic germ cell tumors in female patients and improve the diagnostic level of this disease.

Design, Setting, And Participants: The clinical and CT data of 30 female patients with malignant pelvic germ cell tumors confirmed using histopathology were retrospectively analyzed, before surgery, at a tertiary hospital. Patient's age, tumor location, clinical symptoms, tumor marker levels, and CT findings were recorded. Read More

Int J Gynecol Cancer 2019 11 7;29(9):1405-1410. Epub 2019 Oct 7.

Departamento de Ginecología, Instituto Nacional de Cancerología, Mexico City, Mexico

Background: Dysgerminomas are malignant ovarian germ-cell tumors that typically affect young women. Although these tumors have an excellent response to chemotherapy, surgery is an integral part of primary treatment.

Objective: To evaluate outcomes of initial cytoreduction in patients diagnosed with dysgerminomas. Read More

J Ovarian Res 2019 Sep 23;12(1):89. Epub 2019 Sep 23.

Department of Pathology and Molecular Immunology of the Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua Jorge Viterbo Ferreira nr.228, 4050-313, Porto, Portugal.

Background: Gonadoblastoma (GB) is a rare mixed germ cell-sex cord-stromal tumour, first described in humans, commonly found in dysgenetic gonads of intersex patients that have a Y chromosome. However, this entity in not recognized in the WHO classification of tumours of genital system of domestic animals. Herein, we describe a case of ovarian gonadoblastoma with proliferation of dysgerminoma and sex cord-stromal tumour components, in a phenotypically and cytogenetically normal bitch. Read More

J Pediatr Adolesc Gynecol 2020 Feb 26;33(1):10-14. Epub 2019 Aug 26.

Division of Pediatric Endocrinology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Study Objective: Girls with Turner syndrome with Y-chromosome material (TS + Y) are assumed to have nonfunctional gonads with increased tumor risk, therefore prophylactic gonadectomy is recommended at diagnosis. In this study we aimed to determine rates of spontaneous thelarche (ST) and spontaneous menarche (SM), and prevalence of gonadal tumor and malignancy in girls with TS + Y, to further inform discussions about gonadectomy.

Design: Retrospective review of clinical and pathology data. Read More

Surg Oncol 2019 Dec 20;31:8-13. Epub 2019 Aug 20.

Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. Electronic address:

Background: The standard prognostic system for malignant ovarian germ cell tumors (MOGCT) has not yet been established and the scope of surgery was also controversial. Mixed ovarian malignant germ cell tumor (mGCT) is a rare histological type of MOGCT with higher malignant degree than other types. The aim of the present study was to investigate the clinical features and prognosis of mGCT, and prognostic factors for MOGCT to provide guidance for future treatment. Read More

Klin Onkol 2019 ;32(Supplementum2):79-91

Background: Ovarian tumors in childhood and adolescence are distinguished from those that arise in adulthood by their histological subtype. These tumors may arise as the first manifestation of a cancer predisposition syndrome. Correct diagnosis of the syndrome may offer the possibility of surveillance for other members of the patients family. Read More

Int J Gynecol Cancer 2019 10 30;29(8):1298-1303. Epub 2019 Jul 30.

Department of Medicine and Surgery, University of Milan-Bicocca, Milano, Italy.

Introduction: F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) is a diagnostic tool widely used in oncology, but to date there are no established recommendations for its use in malignant ovarian germ cell tumors. The aim of this study was to evaluate the role of F-FDG PET/CT in the clinical management of patients with malignant ovarian germ cell tumors.

Methods: This was a retrospective review of F-FDG PET/CT scans performed in patients diagnosed with malignant ovarian germ cell tumors treated at the gynecology department of San Gerardo Hospital (Monza, Italy) from June 2006 to December 2016. Read More

J Pediatr Adolesc Gynecol 2019 Dec 26;32(6):645-647. Epub 2019 Jul 26.

Department of Obstetrics and Gynecology, Istanbul University School of Medicine, Istanbul, Turkey.

Background: Swyer syndrome is a rare type of disorder of sex development and typically presents with delayed puberty and primary amenorrhea. We describe an unusual presentation of this condition.

Case: A 17-year-old female patient with typical thelarche and adrenarche presented with primary amenorrhea. Read More

Diagn Cytopathol 2019 Nov 23;47(11):1203-1207. Epub 2019 Jul 23.

Department of Pathology, Dokkyo Medical University.

Ovarian gonadoblastoma coexisting with a dysgerminoma is extremely rare in patients with Turner syndrome (TS) and a Y chromosome. The cytological findings, including imprint cytology, of these unusual ovarian tumors have rarely been reported. We report a rare patient with a gonadoblastoma with dysgerminoma, 3. Read More

Gynecol Oncol Rep 2019 Aug 22;29:55-57. Epub 2019 Jun 22.

Oso Home Care, 17175 Gillette Avenue, Irvine, CA 92614, United States of America.

Dysgerminomas are aggressive germ cell tumors that typically have a favorable prognosis, especially in patients diagnosed with early stage disease. We recount the history of a 23-year-old woman who was treated for a stage IA ovarian dysgerminoma in November 2017. Postoperatively, the patient was noncompliant insofar as obtaining routine lab evaluations; ten months later, she was diagnosed with a cranial metastasis that extended into the meninges. Read More

J Pediatr Adolesc Gynecol 2019 Oct 4;32(5):555-557. Epub 2019 Jul 4.

Department of Surgery, Children's Mercy Hospitals, Kansas City, MO.

Background: Turner syndrome is a genetic disorder resulting from the absence of or structural abnormality of one X chromosome. The presence of Y chromosome material in girls with Turner syndrome confers an increased risk of benign and malignant germ cell tumor and prophylactic bilateral gonadectomy is recommended.

Case: A 10-year-old Turner mosaic syndrome (45X/46XY) patient underwent prophylactic gonadectomy after unremarkable preoperative pelvic imaging. Read More

J Pediatr Adolesc Gynecol 2019 Oct 6;32(5):558-560. Epub 2019 Jun 6.

Department of Anatomic Pathology, University of Campinas, Campinas, São Paulo, Brazil.

Background: Disorders of sex development are congenital conditions with atypical chromosomal, gonadal, or anatomical sex development. Gonadal dysgenesis in patients containing a Y chromosome have a high risk of developing germ cell tumors with potential for malignant transformation.

Case: We present the case of a 17-year-old phenotypic female with primary amenorrhea and 46,XY complete gonadal dysgenesis. Read More

J Am Anim Hosp Assoc 2019 Jul/Aug;55(4):e55402. Epub 2019 May 17.

From the Department Surgical and Radiological Sciences (J.L.W., K.S.H., M.S.K., K.L.P.), School of Veterinary Medicine (C.L.W.), University of California, Davis, Davis, California.

Read More

Surg Pathol Clin 2019 Jun;12(2):621-649

Department of Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard Unit 85, Houston, TX 77030, USA. Electronic address:

Ovarian germ cell tumors are a histologically diverse group of neoplasms with a common origin in the primitive germ cell. The vast majority are represented by mature cystic teratoma. In the minority are malignant germ cell tumors including immature teratoma, dysgerminoma, yolk sac tumor, embryonal cell carcinoma, and choriocarcinoma. Read More

J Clin Pathol 2019 Aug 4;72(8):536-541. Epub 2019 May 4.

Department of Medicine and Surgery, University Milan Bicocca, Milan, Italy

Aims: Very recent papers proposed a possible role for the expression of terminal deoxynucleotidyl transferase (TdT) in the tumourigenesis of gonadal and extragonadal germ cell-derived tumours (GCTs). Our multicentric study evaluated the magnitude of the immunoreactivity for TdT in GCTs, encompassing seminoma, dysgerminoma, mature teratoma and mixed GCTs.

Methods And Results: The histological series was stained with both monoclonal and polyclonal antibodies, yielding a positivity of 80% of cases with well-defined nuclear reactivity. Read More

Open Access Maced J Med Sci 2019 Apr 3;7(7):1174-1179. Epub 2019 Apr 3.

Obstetrics and Gynaecologic Registrar, Obstetrics and Gynecologic Department, Bali, Indonesia.

Background: Malignant Ovarian Germ Cell Tumors (MOGCT) most commonly occur in young women in the reproductive age group. Timely antenatal diagnosis and treatment of the tumour to enhance maternal and perinatal outcomes are the main challenges confronting the obstetrician and the gyne-oncologist.

Case Presentation: Here we present three cases of pregnancy complicated with MOGCTs. Read More

Medicine (Baltimore) 2019 Apr;98(16):e15242

University of Medicine, Pharmacy, Sciences and Technology Târgu Mureş, Romania.

Rationale: Ovarian or adnexal tumors are very rare in patients below the age of 18 years, most of them being functional cysts, only 10% being malignant. We report 3 cases of ovarian tumors with the aim of revealing the particularities regarding the diagnosis and management of benign and malignant ovarian tumors in pediatric patients.

Patient Concerns: The 1st case, a 9-year-old girl presented for diffuse abdominal pain, distended abdomen and rapid increase in abdominal volume. Read More

Eur J Cancer 2019 05 4;113:19-27. Epub 2019 Apr 4.

Barts Health NHS Trust, West Smithfield, London, EC1A 7BE, UK; University College Hospital, 235 Euston Road London, NW1 2BU, UK; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK. Electronic address:

Background: Adult guidelines recommend BEP (bleomycin, etoposide, cisplatin) for all ovarian germ cell tumours, causing debilitating toxicities in young patients who will survive long term. Paediatricians successfully reduce toxicities by using lower bleomycin doses and substituting carboplatin for cisplatin, while testicular and paediatric immature teratomas (ITs) are safely managed with surgery alone.

Aim: The aim was to determine whether reduced-toxicity treatment could rationally be extended to patients older than 18 years. Read More

Semin Diagn Pathol 2019 Jul 1;36(4):246-259. Epub 2019 Feb 1.

Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.

Approximately 5% of gynecological malignancies are associated with paraneoplastic hypercalcemia. Awareness of its association with certain tumor types allows for earlier disease detection and facilitates monitoring of treatment response and disease recurrence. We review the salient clinicopathological features, differential diagnosis and management issues in some of these gynecological tumors, namely: small cell carcinoma, hypercalcemic type; ovarian clear cell carcinoma, dysgerminoma and juvenile granulosa cell tumors. Read More

South Asian J Cancer 2019 Jan-Mar;8(1):35-40

Department of Biostatistics, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India.

Objective: The objective of this study is to evaluate the pattern of care and survival outcome in patients with malignant ovarian germ cell tumors (MOGCTs).

Materials And Methods: Between January 2004 and August 2017, 50 patients with MOGCT were identified at Amrita Institute of Medical Sciences and 48 included in analyses. Histologic subtypes were as follows: dysgerminoma 11; immature teratoma 16; yolk sac tumor 3; and mixed germ cell tumor 18. Read More

Int J Gynecol Cancer 2019 03 29;29(3):554-559. Epub 2019 Jan 29.

Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York City, New York, USA.

Objective: To investigate the prognostic significance of complete gross resection following cytoreductive surgery for patients with advanced stage malignant ovarian germ cell tumors.

Methods: The National Cancer Data Base was accessed and patients diagnosed with an advanced stage (II-IV) malignant ovarian germ cell tumor who underwent primary cytoreductive surgery between 2011 and 2014 were selected for further analysis. For analysis purposes two groups were formed: patients with complete gross resection and those with macroscopic residual disease. Read More

J Gynecol Obstet Hum Reprod 2019 Apr 25;48(4):283-286. Epub 2019 Jan 25.

Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Swyer syndrome also known as pure or complete gonadal dysgenesis is a very rare disorder of sex development wherein the individuals are phenotypically females with 46, XY genotype and preserved mullerian structures. These individuals characteristically have dysgenetic streak gonads which carry an increased risk of malignant transformation. Prophylactic gonadectomy is highly recommended as soon as a clinical diagnosis is established to diminish the chances of tumor development. Read More

Int J Gynecol Cancer 2019 Jan 23. Epub 2019 Jan 23.

Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China

Objective: To evaluate the role of omentectomy and lymphadenectomy in the treatment of clinically apparent early-stage malignant ovarian germ cell tumors.

Methods: We retrospectively reviewed 245 patients with malignant ovarian germ cell tumors (yolk sac tumor, dysgerminoma, and immature teratoma) and with clinically early-stage disease, who were treated at Sun Yat-sen University Cancer Center between January 1, 1970 and December 31, 2017. The survival of patients who underwent either omentectomy or lymphadenectomy, or both (omentectomy/lymphadenectomy group) was compared with that of patients who did not undergo omentectomy or lymphadenectomy (non-omentectomy/lymphadenectomy group). Read More

Comb Chem High Throughput Screen 2018 ;21(9):652-661

Department of Gynecology and Obstetrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Background: Lymphadenectomy has been widely used in the treatment of malignant germ cell tumor of the ovary (OGCT), which is a kind of ovarian cancers occurred mostly in young women and adolescent girls. But the clinical decision mainly depends on the doctor's experience without a well-defined guideline. This population-based study aimed to evaluate the prognostic impact of lymphadenectomy in different stages of malignant germ cell tumors of the ovary. Read More

J Obstet Gynaecol Can 2019 May 12;41(5):660-665. Epub 2018 Dec 12.

Department of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, MB.

Objective: To discuss the finding of hypercalcemia in pediatric ovarian dysgerminoma.

Methods: Two cases of pediatric ovarian dysgerminoma that presented with hypercalcemia are discussed.

Results: Hypercalcemia is a rare finding in ovarian dysgerminoma. Read More

Taiwan J Obstet Gynecol 2018 Dec;57(6):871-877

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Objective: The coexistence of maternal malignancy and pregnancy has received increasing attention in Noninvasive prenatal testing (NIPT) studies. Malignancy in pregnant women potentially affects the copy number variation (CNV) profile in NIPT results. Only one case of hematologic cancer has been reported in a Hong-Kong pregnant women, and solid tumors have never been reported in pregnant Chinese women. Read More

Int J Gynecol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Departments of Obstetrics and Gynecology (N.I., Y.F., T.S., A.K., T.O., F.K.) Pathology (Y. Ikura, Y. Iwai) Hematology (M.O.), Takatsuki General Hospital, Takatsuki, Japan.

Primary ovarian lymphomas are rare, but can potentially evoke diagnostic problems. We present a case of ovarian lymphoma, in which an ambiguous intraoperative pathologic report led to overtreatment (unnecessary surgery). A 73-yr-old woman with fatigue and low-grade fever was diagnosed as having a left ovarian tumor by imaging modalities. Read More

Int J Surg Pathol 2019 Jun 25;27(4):387-389. Epub 2018 Nov 25.

1 Rutgers-New Jersey Medical School, Newark, NJ, USA.

Primary lymphoma of the ovary, particularly in an HIV-positive woman, is exceptionally rare, and ovarian lymphoma may not be considered at the time of intraoperative consultation. In this article, we present a case in an HIV-positive woman thought to be a dysgerminoma at the time of frozen section, but which was found to be a diffuse large B-cell lymphoma of the ovary. Read More

Pediatr Int 2018 Oct;60(10):982-983

Department of Pediatrics, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Br J Cancer 2018 10 5;119(7):864-872. Epub 2018 Oct 5.

Division of Epidemiology & Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.

Background: Abnormal DNA methylation may be important in germ cell tumour (GCT) aetiology, as germ cells undergo complete epigenetic reprogramming during development. GCTs show differences in global and promoter methylation patterns by histologic subtype. We conducted an epigenome-wide study to identify methylation differences by GCT histology. Read More

Int J Gynecol Pathol 2019 Nov;38(6):581-587

Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana (L.M.R.) Spectrum Health, Grand Rapids, Michigan (M.M.D.) Patho-Lab Diagnostics, Nes-Ziona, Israel (B.C.).

Herein, we report a case of a 9-yr-old girl who had a 46, XX peripheral karyotype and apparent developmentally normal ovaries. She presented with abdominal pain and a right adnexal mass. No clinical or pathologic evidence of gonadal dysgenesis or undifferentiated gonadal tissue was detected. Read More

Ann Med Surg (Lond) 2018 Sep 21;33:50-52. Epub 2018 Aug 21.

Faculdade de Medicina (FAMED) - Universidade Federal do Rio Grande (FURG), Rio Grande city, Rio Grande do Sul State, Brazil.

Introduction: Malignant ovarian germ cell tumors (MOGCTs) are rare malignancies with an incidence of about 0.5/100,000. They account for less than 5% of all ovarian tumors, of which 32. Read More

Gynecol Oncol 2018 10 28;151(1):61-68. Epub 2018 Aug 28.

Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; Division of Gynaecological Oncology, Leuven Cancer Institute, Kuleuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

Background: Ovarian germ cell tumors (OGCT) are rare gynecological neoplasms, mostly affecting children and young women. The underlying molecular genetic background of these tumors is poorly characterized.

Methods: We analyzed somatic copy number aberration (CNA) profiles in 87 OGCT tumors and performed whole exome sequencing (WES) on 24 OGCT tumor and matched germline samples to further elucidate their molecular genetic landscape. Read More

J Neurol 2018 Oct 12;265(10):2190-2200. Epub 2018 Jul 12.

French Reference Center for Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hôpital Neurologique, 69677, Bron, France.

Objective: The aim of this study was to describe specificities of patients with NMDA receptor antibody (NMDAR-Ab) encephalitis associated with a malignant tumor.

Methods: Retrospective observational study of 252 patients with NMDAR-Ab encephalitis of the French Paraneoplastic Neurological Syndrome Reference Center. Patients were classified in three groups: (1) non-malignant ovarian teratomas, (2) malignant ovarian teratomas (immature), and (3) other malignant tumors. Read More

Zhonghua Bing Li Xue Za Zhi 2018 Jul;47(7):531-535

Department of Pediatric Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.

To investigate the pathologic features of gonadal tissues of disorders of sexual development (DSD) in children. Fifty-three cases of gonadal developmental disorders were collected from July 2015 to August 2017 at Guangzhou Women and Children's Medical Center. Clinical manifestations, karyotypes, sex hormone levels, ultrasound imaging, histology and immunophenotype of gonadal tissues were analyzed. Read More

Cureus 2018 Apr 23;10(4):e2522. Epub 2018 Apr 23.

Department of Pathology & Laboratory Medicine, The Aga Khan University, Karachi, PAK.

Dysgerminomas are malignant germ cell tumors of the ovary that most commonly occur in the adolescent population. Ovarian dysgerminoma presenting with complications like torsion is a rare entity in the pediatric age group. Cross-sectional imaging plays a crucial role in diagnosis, tumor staging before surgical resection, and for planning adjuvant chemotherapy. Read More