24,750 results match your criteria Ovarian Cysts


A rare case of ovarian adenomyoma mimicking primary invasive ovarian cancer with a contralateral serous borderline ovarian tumor: A case report and review of the literature.

Heliyon 2020 Jul 24;6(7):e04406. Epub 2020 Jul 24.

Academic Department of Gynecology and Obstetrics, University of Turin, Mauriziano Hospital, Turin, Italy.

Extrauterine adenomyoma is a rare type of benign tumor, characterized by nodular aggregate of smooth muscle, endometrial glands and endometrial stroma, arising outside the uterus. In this study we describe a case of primary ovarian adenomyoma associated with endometriotic cysts with contralateral serous borderline tumor in a 40-year-old woman and we highlight how preoperative exams could lead to the suspicious of invasive cancer. We provide a review of the literature, analyzing all cases of extrauterine adenomyoma published so far, classifying them on the basis of pathogenetic theories proposed, localization of the lesion, imaging modalities and treatment adopted. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385463PMC

Guideline No. 404: Initial Investigation and Management of Benign Ovarian Masses.

J Obstet Gynaecol Can 2020 Aug;42(8):1040-1050.e1

Toronto, ON.

Objective: To provide recommendations for a systematic approach to the initial investigation and management of a benign ovarian mass and facilitate patient referral to a gynaecologic oncologist for management.

Intended Users: Obstetricians, gynaecologists, family physicians, internists, nurse practitioners, radiologists, general surgeons, medical students, medical residents, fellows, and other health care providers.

Target Population: Women ≥18 years of age presenting for evaluation of an ovarian mass (including simple and unilocular cystic masses, endometriomas, dermoids, fibromas, and hemorrhagic cysts) who are not acutely symptomatic and without known genetic predisposition to ovarian cancer. Read More

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http://dx.doi.org/10.1016/j.jogc.2020.01.014DOI Listing

Is serum anti-Müllerian hormone (AMH) assay a satisfactory measure for ovarian reserve estimation? A comparison of serum and peritoneal fluid AMH levels.

Adv Clin Exp Med 2020 Jul 31. Epub 2020 Jul 31.

Department of Gynecological Surgery and Oncology, Medical University of Lodz, Poland.

Background: Clinical cases have been reported with women who got pregnant with confirmed low serum anti-Müllerian hormone (AMH) concentrations, thus demonstrating that low serum AMH concentration cut-points could be fairly specific for poor ovarian response (POR) to gonadotrophin stimulation, but not for pregnancy. That observation prompted the question whether serum AMH concentration accurately corresponded to the whole amount of AMH secreted by granulosa cells.

Objectives: To measure AMH levels in peritoneal fluid and their correlations with serum AMH concentrations. Read More

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http://dx.doi.org/10.17219/acem/121010DOI Listing

MORE THAN MEETS THE EYE IN A PATIENT WITH PCOS: ANDROGEN-SECRETING GRANULOSA CELL OVARIAN TUMOR IN A VIRILIZED WOMAN WITH POLYCYSTIC OVARIAN SYNDROME (PCOS).

AACE Clin Case Rep 2020 Jul-Aug;6(4):e170-e173. Epub 2020 Apr 3.

Objective: Granulosa cell ovarian tumors are known to secrete estrogen. Herein we report a patient presenting with primary amenorrhea and virilization with markedly high androgen levels, all thought to be disproportional to be attributed to polycystic ovary syndrome (PCOS) alone. Bilateral oophorectomy revealed a rare androgen-secreting granulosa cell ovarian tumor and bilateral cysts (PCOS) both contributing to manifestations. Read More

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http://dx.doi.org/10.4158/ACCR-2019-0576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388264PMC

Ascorbic Acid and Alpha-Tocopherol Contribute to the Therapy of Polycystic Ovarian Syndrome in Mouse Models.

Reprod Sci 2020 Jul 28. Epub 2020 Jul 28.

Department of Pharmacology and Toxicology, University of Benin, Benin City, Edo State, Nigeria.

Polycystic ovary syndrome (PCOS) affects up to 10% of women within reproductive ages and has been a cause of infertility and poor quality of life. Alteration in the oxidant-antioxidant profile occurs in PCOS. This study, therefore, investigates the contribution of ascorbic acid (AA) and alpha-tocopherol(ATE) on different PCOS parameters. Read More

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http://dx.doi.org/10.1007/s43032-020-00273-9DOI Listing

Giant paratubal cyst presenting as adnexal torsion: A case report.

Case Rep Womens Health 2020 Jul 19;27:e00222. Epub 2020 May 19.

Hospital Vila Franca de Xira, Vila Franca de Xira, Portugal.

Background: Paraovarian/paratubal cysts constitute about 10% of adnexal masses and are usually small and asymptomatic. A huge paratubal cyst complicated by adnexal torsion is a rare cause of acute low abdominal pain.

Case Report: We report the case of an obese 31-year-old nulliparous woman who presented with a large pelvic cyst causing ovarian torsion. Read More

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http://dx.doi.org/10.1016/j.crwh.2020.e00222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371974PMC

Paratubal Cyst Recurrence in Children and Adolescents.

J Pediatr Adolesc Gynecol 2020 Jul 24. Epub 2020 Jul 24.

Division of Pediatric and Adolescent Gynecology; Department of Obstetrics and Gynecology; Department of Pediatrics; Baylor College of Medicine, Houston, Texas; Texas Children's Hospital.

Study Objective: To examine the association between patient characteristics and risk for recurrence risk of paratubal cysts (PTC) in children and adolescents DESIGN: Retrospective chart review at a single institution SETTING: Single academic children's hospital PARTICIPANTS: Pediatric patients presenting to Texas Children's Hospital between July 2007 and March 2019. Patients were identified for the study by reviewing pathology reports and were included if they met inclusion criteria of a pathologic diagnosis of a paratubal or paraovarian cyst removed during any surgical procedure between July 2007 and March 2019 INTERVENTIONS: Subjects with pathologic diagnoses of a paratubal cyst during the study period underwent chart review for the following data points: age at presentation, ethnicity, pathologic recurrence of paratubal cysts, pubertal status, body mass index (BMI), diagnosis of polycystic ovary syndrome (PCOS), size of cyst, laterality of cysts, and number of cysts.

Main Outcome Measure(s): Recurrence, Pathology types RESULTS: Of the 627 patients that met inclusion criteria, the incidence of recurrence was 11. Read More

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http://dx.doi.org/10.1016/j.jpag.2020.07.008DOI Listing

Ovarian Histopathology in Transmasculine Persons on Testosterone: A Multicenter Case Series.

J Sex Med 2020 Jul 20. Epub 2020 Jul 20.

Department of Pediatric and Adolescent Gynecology, National Institute for Child Health and Human Development, Bethesda, MA, USA.

Background: As transmasculine persons utilize androgen gender affirming hormone therapy as a part of transition, guidance has been lacking on the effects of the therapy on the ovaries, especially for those who may desire retention.

Aim: To describe the ovarian histopathology of transmasculine persons on testosterone therapy following oophorectomy at the time of hysterectomy performed for gender affirmation.

Methods: This was a multicenter case series study of transmasculine patients on testosterone therapy who underwent hysterectomy with oophorectomy for gender affirmation between January 2015 and December 2017 at 5 tertiary care referral centers. Read More

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http://dx.doi.org/10.1016/j.jsxm.2020.05.029DOI Listing

Giant abdominal cyst in a young female patient: A case report.

Int J Surg Case Rep 2020 24;72:549-555. Epub 2020 Jun 24.

General Surgery, Centro Hospitalar Tondela-Viseu, 3504-509, Viseu, Portugal.

Introduction: Most abdominal cysts derive from the ovary. The range of differential diagnoses is wide. Unfortunately, imaging studies not always determine its origin. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327878PMC

Calcified Sister Mary Joseph nodule as the presenting complaint of advanced low-grade serous ovarian cancer.

Radiol Case Rep 2020 Sep 15;15(9):1638-1642. Epub 2020 Jul 15.

Department of Medical Imaging, Royal University Hospital, University of Saskatchewan; Room 1566, 103 Hospital Drive, Saskatoon, SK, Canada, S7N 0W8.

A healthy 38-year-old woman presented with a hard umbilical mass that has been growing for a few months in duration with no other significant symptoms and signs. Computed tomography images identified a lobulated densely calcified umbilical mass, left ovarian cysts, a subcentimeter calcified omental nodule, and nonspecific punctate pelvic calcifications. Histopathology of the mass revealed low-grade serous carcinoma with postsurgical diagnosis of International Federation of Gynecology and Obstetrics (FIGO) stage IV ovarian cancer. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.06.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364121PMC
September 2020

Ovary and uterus related adverse events associated with statin use: an analysis of the FDA Adverse Event Reporting System.

Sci Rep 2020 Jul 20;10(1):11955. Epub 2020 Jul 20.

Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

Experimental studies have demonstrated statin-induced toxicity for ovary and uterus. However, the safety of statins on the functions of ovary and uterus in real-world clinical settings remains unknown. The aim of this study was to identify ovary and uterus related adverse events (AEs) associated with statin use by analyzing data from FDA Adverse Event Reporting System (FAERS). Read More

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http://dx.doi.org/10.1038/s41598-020-68906-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371681PMC

A prospective, randomized study of Toremifene vs. tamoxifen for the treatment of premenopausal breast cancer: safety and genital symptom analysis.

BMC Cancer 2020 Jul 16;20(1):663. Epub 2020 Jul 16.

Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Second Road, Shanghai, 200025, China.

Background: Toremifene (TOR) is a selective oestrogen receptor modulator (SERM) and has comparable efficacy to that of tamoxifen (TAM) in breast cancer patients. Herein, we compared the safety of TOR to that of TAM in the adjuvant treatment of premenopausal breast cancer.

Methods: This was a prospective randomized and open-label clinical study. Read More

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http://dx.doi.org/10.1186/s12885-020-07156-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364473PMC

The Feasibility of Natural Orifice Transluminal Endoscopic Surgery in Gynecology Practice: Single-Surgeon Experience.

Gynecol Minim Invasive Ther 2020 Apr-Jun;9(2):69-73. Epub 2020 Apr 28.

Department of Obstetrics and Gynecology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Objectives: Natural orifice transluminal endoscopic surgery (NOTES) has been performed in gynecology practice for the surgical treatment of ovarian cysts, uterine fibroids, ectopic pregnancies, adnexal masses, and pelvic organ prolapse. The aim of this study is to evaluate the intraoperative and postoperative outcomes of patients who underwent NOTES for gynecological diseases.

Materials And Methods: This study was a retrospective clinical study. Read More

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http://dx.doi.org/10.4103/GMIT.GMIT_84_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354749PMC

The Diagnostic Accuracy of Magnetic Resonance Imaging for Maternal Acute Adnexal Torsion during Pregnancy: Single-Institution Clinical Performance Review.

J Clin Med 2020 Jul 13;9(7). Epub 2020 Jul 13.

Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Ulsan University Hospital, 44033 Ulsan, Korea.

Background: For acute adnexal torsion of pregnant women, appropriate treatment based on an accurate diagnosis is especially important for fertility preservation and timely treatment. The 2017 American College of Obstetricians and Gynecologists (ACOG) Committee Opinion No. 723 announced its practice-changing guidelines to ensure that diagnostic magnetic resonance imaging (MRI) conducted during the first trimester and gadolinium exposure at any time during pregnancy are safe for fetal stability. Read More

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http://dx.doi.org/10.3390/jcm9072209DOI Listing

Polycystic ovary syndrome (PCOS) and COVID-19: an overlooked female patient population at potentially higher risk during the COVID-19 pandemic.

BMC Med 2020 07 15;18(1):220. Epub 2020 Jul 15.

Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, CV2 2DX, UK.

Background: In women of reproductive age, polycystic ovary syndrome (PCOS) constitutes the most frequent endocrine disorder. Women with PCOS are considered to typically belong to an age and sex group which is at lower risk for severe COVID-19.

Main Body: Emerging data link the risk of severe COVID-19 with certain factors such as hyper-inflammation, ethnicity predisposition, low vitamin D levels, and hyperandrogenism, all of which have known direct associations with PCOS. Read More

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http://dx.doi.org/10.1186/s12916-020-01697-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360476PMC

The relationship between retroperitoneal lymphadenectomy and survival in advanced ovarian cancer patients.

BMC Cancer 2020 Jul 13;20(1):654. Epub 2020 Jul 13.

Department of Gynecological Oncology, Cancer Hospital of University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Cancer Research and Basic Medicine (IBMC), Chinese Academy of Sciences, 1 Banshan East Road, Hangzhou, 310022, Zhejiang Province, China.

Background: Systematic retroperitoneal lymphadenectomy has been widely used in the surgical treatment of advanced ovarian cancer patients. Nevertheless, the corresponding therapeutic may not provide a survival benefit. The aim of this study was to assess the effect of systematic retroperitoneal lymphadenectomy in such patients. Read More

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http://dx.doi.org/10.1186/s12885-020-07144-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359502PMC

Expression levels of circulatory mir-185-5p, vascular endothelial growth factor, and platelet-derived growth factor target genes in endometriosis.

Int J Reprod Biomed (Yazd) 2020 May 31;18(5):347-358. Epub 2020 May 31.

Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Using blood-based biomarkers such as microRNAs (miRNAs) may allow particularly effective and minimally invasive diagnosis and treatment of endometriosis. We evaluated the differential expression of circulating miRNA-185-5p (miR-185-5p), vascular endothelial growth factor , and platelet-derived growth factor target genes between endometriosis and healthy women.

Materials And Methods: 25 women with a history of endometriosis (grad III-IV) diagnosed by laparoscopy as the case group and 25 women without endometriosis underwent laparoscopy for ovarian cysts or pelvic pain as the control group were enrolled in this case-control study. Read More

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http://dx.doi.org/10.18502/ijrm.v13i5.7155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306060PMC

Efficacy of clomifene citrate combined Bushen Culuan Decoction for the treatment of infertility caused by polycystic ovary syndrome: A protocol of systematic review.

Medicine (Baltimore) 2020 Jul;99(27):e20969

Department of Gynecology, Xi'an Hospital of Traditional Chinese Medicine, Xi'an, China.

Background: The aim of this study is to assess the efficacy and safety of clomifene citrate combined Bushen Culuan Decoction (CCBCD) in treating infertility caused by polycystic ovary syndrome (PCOS).

Methods: We will carry out this study to identify eligible randomized controlled trials (RCTs) in Cochrane Library, PUBMED, EMBASE, Web of Science, CINAHL, and China National Knowledge Infrastructure from inception to the present. There are no limitations to the language and publication time. Read More

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http://dx.doi.org/10.1097/MD.0000000000020969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337480PMC

Sertoli-Leydig cell tumor in two siblings with DICER1 syndrome: A case report and literature review.

Medicine (Baltimore) 2020 Jul;99(27):e20806

Department of Cancer Center.

Rationale: DICER1 syndrome is an autosomal-dominant tumor predisposition syndrome associated with numerous cancerous and noncancerous conditions. The most common sex cord-stromal tumor associated with DICER1 syndrome is Sertoli-Leydig cell tumor of the ovary (SLCT), which is extremely unusual and accounts for < 0.5% of all ovarian neoplasms. Read More

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http://dx.doi.org/10.1097/MD.0000000000020806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337485PMC

The relationship of ovarian endometrioma and its size to the preoperative serum anti-Mullerian hormone level.

Ginekol Pol 2020 ;91(6):313-319

Pusan National University Hospital Medical Research Institute, Busan, Republic of Korea.

Objectives: The aim of this study is to evaluate the impact of ovarian endometrioma according to its size on the serum anti-Mullerian hormone (AMH) levels compared to that of other benign ovarian cysts.

Material And Methods: The current study retrospectively evaluated preoperative serum AMH level and its association to presenting ovarian cyst size which were measured in clinical setting. Women with surgically diagnosed endometrioma or other benign ovarian cysts were included. Read More

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http://dx.doi.org/10.5603/GP.2020.0060DOI Listing
January 2020

Ovarian sparing cystectomy for borderline serous tumor through vNOTES (vaginal Natural Orifices Transluminal Endoscopic Surgery).

Int J Gynecol Cancer 2020 Jul 5. Epub 2020 Jul 5.

Gynecologic Oncology, ACCamargo Cancer Center, Sao Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1136/ijgc-2020-001513DOI Listing

Aromatase deficiency: A case series of 46, XX Chinese children and a systematic review of the literature.

Clin Endocrinol (Oxf) 2020 Jul 5. Epub 2020 Jul 5.

Department of Endocrinology, Genetics, Metabolism, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, China.

Background: Aromatase deficiency (AD) caused by cytochrome P450 family 19 subfamily A polypeptide 1 (CYP19A1) variants is characterized by a deficiency in androgen-to-oestrogen conversion.

Objective: To investigate the clinical characteristics and accurate management of aromatase-deficient children.

Patients And Methods: We described three 46, XX aromatase-deficient children, searched PubMed with "(aromatase deficiency) AND (46, XX OR ovaries)" and manually searched citations in identified studies for the literature review. Read More

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http://dx.doi.org/10.1111/cen.14277DOI Listing

Efficacy of ovulation synchronization with timed artificial insemination in treatment of follicular cysts in dairy cows.

Theriogenology 2020 May 21;154:171-180. Epub 2020 May 21.

Department of Surgery, Faculty of Veterinary Medicine, Zagazig University, Zagazig City, 44511, Al Sharquiya Governorate, Egypt; Veterinary Epidemiology, Economics and Public Health Group, Department of Pathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield, AL9 7TE, UK.

The efficacy of five ovulation-synchronization protocols with FTAI in treatment of cows diagnosed with follicular cysts was investigated in a nonrandomized study in a single herd. Cows identified with follicular structures >25 mm on two subsequent ultrasonographic (USG) examinations 7-10 days apart (n = 552) were assigned to one of the five treatment regimens on the day of the second USG examination. Treatment regimens were Ovsynch (GnRH-7d-PGF2α-56 h-GnRH-16 h-FTAI), New-CIDR (as Ovsynch with a new CIDR insert being fitted between days 0 and 7), Reused-CIDR (as New-CIDR but the CIDR insert was previously used for 7 days in another cow), G-New CIDR (Pre-GnRH on day 0 with the New-CIDR regimen being initiated 7 days later), and RG-Ovsynch (Pre-GnRH on day 0 and then every 7 days until detection of a luteal structure upon USG examination; at that point the Ovsynch was initiated). Read More

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http://dx.doi.org/10.1016/j.theriogenology.2020.05.029DOI Listing

Hysterectomy and Oophorectomy in Reproductive Age: A Cross-Sectional Study from a Tertiary Care Hospital.

Cureus 2020 May 28;12(5):e8344. Epub 2020 May 28.

Pathology, Dow Medical College, Dow University of Health Sciences, Karachi, PAK.

Introduction Hysterectomy is a common surgical procedure in women, and oophorectomy may also be performed with the hysterectomy. The objective of this study was to identify clinical indications and pathological findings in hysterectomies, performed for gynecological causes, in women of reproductive age (15-49 years) and to determine if oophorectomy or ovarian conservation was performed with the hysterectomy as well as the pathological findings in the ovaries. Methods This cross-sectional study was conducted in the department of Pathology at Dow Medical College in Karachi, Pakistan, from September 2017 to December 2018. Read More

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http://dx.doi.org/10.7759/cureus.8344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325352PMC

An Analysis of and Gene Expression Levels in Women With Endometriosis.

In Vivo 2020 Jul-Aug;34(4):1765-1771

Department of Operative Gynaecology and Oncological Gynaecology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.

Aim: The analysis of oestrogen receptor (ESR2) and cytochrome P450 family 19 subfamily A member (CYP19A1) gene expression in the context of the risk for endometriosis development.

Materials And Methods: Tissue specimens, collected from patients with endometriosis (n=100) and from control patients (n=100) embedded into paraffin blocks, provided the material for genetic studies, oriented towards the expression of ESR2 and CYP19A1 genes. The gene expression was assessed by the reverse transcription-polymerase chain reaction technique. Read More

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http://dx.doi.org/10.21873/invivo.11970DOI Listing

Endometriosis-Associated Ovarian Cancer: The Origin and Targeted Therapy.

Cancers (Basel) 2020 Jun 24;12(6). Epub 2020 Jun 24.

Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osakasayama, Osaka 589-8511, Japan.

Endometrial cysts (ECs) are thought to be the origin of endometriosis-associated ovarian cancer (EAOC). A hypothesis that the oxidative stress of iron in cysts causes "malignant transformation of ECs" has been proposed, but this has not been verified. Several population-based studies showed that endometriosis was a risk factor but did not reflect the "malignant transformation of ECs". Read More

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http://dx.doi.org/10.3390/cancers12061676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352633PMC

Gynecologic Risk Mitigation Considerations for Long-Duration Spaceflight.

Aerosp Med Hum Perform 2020 Jul;91(7):543-564

As NASA and its international partners, as well as the commercial spaceflight industry, prepare for missions of increasing duration and venturing outside of low-Earth orbit, mitigation of medical risk is of high priority. Gynecologic considerations constitute one facet of medical risk for female astronauts. This manuscript will review the preflight, in-flight, and postflight clinical evaluation, management, and prevention considerations for reducing gynecologic and reproductive risks in female astronauts. Read More

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http://dx.doi.org/10.3357/AMHP.5538.2020DOI Listing

Appraisal of EUS-guided needle-based confocal laser endomicroscopy in the diagnosis of pancreatic lesions: A single Chinese center experience.

Endosc Ultrasound 2020 May-Jun;9(3):180-186

Gastroenterology and Endoscopy, Huashan Hospital, Fudan University, Shanghai, China.

Background And Objectives: In the recent years, EUS is one of the routine procedures in the diagnosis of pancreatic diseases. EUS-guided needle-based confocal laser endomicroscopy (nCLE) is a novel minimally invasive imaging technique in diagnosis of pancreatic diseases. The pilot researches provided us some preliminary findings and conclusions with small samples, low rate of pathological correspondence. Read More

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http://dx.doi.org/10.4103/eus.eus_9_20DOI Listing

Efficacy of clomifene citrate for the treatment of patients with polycystic ovary syndrome: A protocol of systematic review.

Medicine (Baltimore) 2020 Jun;99(25):e20590

Department of Obstetrics and Gynecology, 521 Hospital of Norinco Group.

Background: This study aims to assess the efficacy and safety of clomifene citrate (CC) for the treatment of patients with polycystic ovary syndrome (PCOS).

Methods: In this study, we will comprehensively search MEDLINE, EMBASE, The Cochrane Library, Web of Science, CINAHL, ACMD, PsycINFO, and China National Knowledge Infrastructure for original articles published from their inceptions to the January 1, 2020 without language restrictions. All studies will undergo relevance and a design selecting process. Read More

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http://dx.doi.org/10.1097/MD.0000000000020590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310963PMC

Decreased Expression of Peroxiredoxin in Patients with Ovarian Endometriosis Cysts.

Arch Med Res 2020 Jun 18. Epub 2020 Jun 18.

Department of Obstetrics and Gynecology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China. Electronic address:

Background: Endometriosis (EMT) is a common occurrence in women of reproductive age. Since oxidative stress has been associated with the development and/or progression of the disease, the present study was conducted to detect the expression of peroxiredoxin (PRX) isoforms, including PRX1, PRX2, and PRX3.

Methods: Fifty-two patients with ovarian endometriosis cysts and 47 controls were included in the study. Read More

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http://dx.doi.org/10.1016/j.arcmed.2020.06.005DOI Listing

Reproductive hormone metabolism in women with infertility due to polycystic ovary syndrome depending on the constitutional body types.

Pol Merkur Lekarski 2020 Jun;48(285):152

I. Horbachevsky Ternopil National Medical University, Ukraine: Department of Obstetrics and Gynaecology No.1.

Overweight or obesity is diagnosed in approximately 60-80% of polycystic ovary syndrome (PCOS) patients. Since obesity exacerbates the hormonal and clinical features of PCOS, and women suffering from PCOS have a high risk of obesity, we suggest that hormonal imbalance resulting in certain body features can be linked to the pathogenesis of PCOS.

Aim: The aim of the study was to define the features of the reproductive hormone metabolism in women with infertility due to PCOS depending on the constitutional body types. Read More

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Utility of ultrasound after a negative CT abdomen and pelvis in the emergency department.

Clin Imaging 2020 Jun 12;68:29-35. Epub 2020 Jun 12.

Staten Island University Hospital, Northwell Health, 475 Seaview Ave, Staten Island, NY 10305, USA.

Purpose: The purpose of this study is to assess the utility of an abdominal and/or pelvic ultrasound (US) performed within 24 h after a negative CT of the abdomen and pelvis (CTAP) in the emergency department (ED). The secondary endpoint is to assess whether there is a significant increase in length of stay (LOS) in the ED due to immediate US reimaging.

Method: We reviewed the imaging reports of 335 patients over the course of 3 years in our ED who had an US within 24 h after a negative CTAP. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.06.007DOI Listing

Nonalcoholic fatty liver disease in women with polycystic ovary syndrome: associated factors and noninvasive fibrosis staging in a single Brazilian center.

Arch Endocrinol Metab 2020 May-Jun;64(3):235-242

Pós-Graduação em Ciências Aplicadas à Saúde do Adulto, Universidade Federal de Minas Gerais , Belo Horizonte , MG , Brasil.

Objective: Polycystic ovary syndrome (PCOS) is a recognized risk factor for nonalcoholic fatty liver disease (NAFLD). The aims of this study were to investigate the prevalence and factors associated with NAFLD in women with PCOS and evaluate noninvasive indices of hepatic fibrosis in patients with PCOS and NAFLD.

Subjects And Methods: Patients with PCOS (n = 87) and women without PCOS (n = 40; controls) were included. Read More

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http://dx.doi.org/10.20945/2359-3997000000242DOI Listing

A 5-year-old girl with tall stature and painless vaginal bleeding.

Paediatr Child Health 2020 Jun 13;25(4):203-204. Epub 2019 Apr 13.

Department of Pediatrics, IWK Health Centre, Halifax, Nova Scotia.

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http://dx.doi.org/10.1093/pch/pxz029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286738PMC

Salpingo Enteric Fistula: A Case Report.

Int Med Case Rep J 2020 22;13:221-224. Epub 2020 May 22.

Department of General Surgery, Urmia University of Medical Science, Urmia, Iran.

Background: Few cases with fistulous communication between the GI system and female adnexal structure have been reported in the literature, and bilateral contrast spillage has been reported only in one case, and this case is the second one all over the world.

Case Presentation: The case was a 27-year-old woman with a diagnosis of primary infertility. She was booked with hysterosalpingogram (HSG) as part of the routine workup in the infertility clinic. Read More

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http://dx.doi.org/10.2147/IMCRJ.S251652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250311PMC

circPUM1 promotes polycystic ovary syndrome progression by sponging to miR-760.

Gene 2020 Sep 12;754:144903. Epub 2020 Jun 12.

Operating Room, Huai'an Second People's Hospital, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China. Electronic address:

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among reproductive-age women. The circRNA-miRNA axis functions in various diseases progression have been partially revealed in the past two decades. However, little is known about the role of the circRNA-miRNA axis in PCOS progression. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144903DOI Listing
September 2020

Ultrasound features of immature ovarian teratomas: Case series and review of literature.

Ultrasound 2020 May 11;28(2):82-90. Epub 2020 Feb 11.

School of Medical Education, Kings College Hospital, London, UK.

Introduction: Immature ovarian teratomas are rare but account for 10-20% of ovarian cancers in women under the age of 20 years. This study aimed to characterise immature ovarian teratomas using grey-scale and Doppler ultrasonography and review the literature to refine the diagnosis of immature ovarian teratomas.

Methods: Patients with a confirmed histological diagnosis of immature ovarian teratoma from years 2006-2018, who had undergone a transvaginal ultrasound at two large teaching hospitals, were identified. Read More

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http://dx.doi.org/10.1177/1742271X19895538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254944PMC

Antenatally detected abdominal cyst: Does cyst size and nature determine postnatal symptoms and outcome?

Early Hum Dev 2020 Aug 3;147:105102. Epub 2020 Jun 3.

University of Edinburgh, School of Medicine, United Kingdom of Great Britain and Northern Ireland; Department of Paediatric Surgery, Royal Hospital for Sick Children, 9 Sciennes Road, Edinburgh EH9 1LF, United Kingdom of Great Britain and Northern Ireland. Electronic address:

Background: The outcome of antenatally detected fetal intra-abdominal cysts is highly variable and challenging to predict. Antenatal ultrasound scans may be of value in predicting postnatal outcome.

Aims: To report antenatal and postnatal course of fetal intra-abdominal cysts identified on antenatal ultrasound and establish the value of cyst dimensions for predicting outcome. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2020.105102DOI Listing

Applying the vaginal approach for benign ovarian cystectomy: current evidence and future applications.

Future Sci OA 2020 Apr 15;6(5):FSO470. Epub 2020 Apr 15.

West London Gynaecological Cancer Centre, Queen Charlotte's Hospital, Hammersmith Hospital Campus, Imperial College London, Du Cane Road, London W12 0HS, UK.

Vaginal ovarian cystectomy has not gained wide acceptance owing to the potential difficulty in entering the cul-de-sac. We review the current evidence on vaginal approaches to benign ovarian cysts. Outcome measures of interest included time to return to work, patient satisfaction, surgical complications and length of hospital stay. Read More

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http://dx.doi.org/10.2144/fsoa-2019-0138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273401PMC

A young woman from an Echinococcus-endemic area with progressive abdominal distension: a case report.

J Med Case Rep 2020 Jun 8;14(1):65. Epub 2020 Jun 8.

Divison of Hepatology, Clinic of Gastroenterology, Hepatology, Infectious Diseases and Pneumology, University Hospital Leipzig, Liebigstraße 20, 04103, Leipzig, Germany.

Background: Cystic echinococcosis is a zoonotic infection caused by Echinococcus granulosus. This case report shows the difficulty in differential diagnosis in a patient with highly suspected hydatid disease.

Case Presentation: A 29-year-old Chinese woman presented with progressive abdominal distension. Read More

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http://dx.doi.org/10.1186/s13256-020-02388-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278052PMC

How often do we incidentally find a fetal abnormality at the routine third-trimester growth scan? A population-based study.

Am J Obstet Gynecol 2020 Jun 3. Epub 2020 Jun 3.

Nuffield Department of Women's and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom. Electronic address:

Background: Third-trimester scans are increasingly used to try to prevent adverse outcomes associated with abnormalities of fetal growth. Unexpected fetal malformations detected at third-trimester growth scans are rarely reported.

Objective: To determine the incidence and type of fetal malformations detected in women attending a routine third-trimester growth scan. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.05.052DOI Listing

Psychological well-being and personality in relation to weight loss following behavioral modification intervention in obese women with polycystic ovary syndrome: a randomized controlled trial.

Eur J Endocrinol 2020 Jul;183(1):1-11

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Objective: Little is known about how lifestyle affects psychological well-being in overweight women with polycystic ovary syndrome (PCOS). We investigated the effects of behavioral modification on psychological well-being and the impact of well-being and personality traits on successful weight loss.

Design: A 4-month randomized controlled trial with a 12-month follow-up at a University Hospital. Read More

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http://dx.doi.org/10.1530/EJE-20-0066DOI Listing

Effects of vitamin D supplementation on serum lipid profile in women with polycystic ovary syndrome: A protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(23):e20621

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, P.R. China.

Background: Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder in reproductive-aged women. In addition to the reproductive consequences, PCOS is also characterized by a metabolic disorder, which may play a part in the etiology of anovulation and has important implications for long-term health as well. Vitamin D deficiency is prevalent in PCOS and there is a close relationship between metabolic dysfunction and vitamin D status in women with PCOS. Read More

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http://dx.doi.org/10.1097/MD.0000000000020621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306319PMC

A cystectomic technique with low risk of rupture for women with benign ovarian cyst.

J Obstet Gynaecol 2020 Jun 4:1-3. Epub 2020 Jun 4.

Department of Obstetrics and Gynecology, Saitama Medical Center, The Jichi Medical University, Saitama, Japan.

The majority of patients with benign ovarian cysts undergo laparoscopic surgery using both cystectomy and stripping techniques. However, these techniques have difficulty correctly identifying cleavage planes and are prone to cyst rupture. We present a surgical cystectomy technique that correctly identifies the cleavage plane with a low risk of ovarian cyst rupture, even in patients with multicystic ovarian cysts. Read More

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http://dx.doi.org/10.1080/01443615.2020.1755622DOI Listing
June 2020
0.604 Impact Factor

Systemic Inflammatory Response Markers Associated with Infertility and Endometrioma or Uterine Leiomyoma in Endometriosis.

Ther Clin Risk Manag 2020 11;16:403-412. Epub 2020 May 11.

Institute of Basic Medical Sciences, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan, Shandong 250012, People's Republic China.

Purpose: The aim of this study was to find the most useful marker of endometriosis-related infertility and evaluate predictive and diagnostic values of systemic inflammatory response markers (preoperative white blood-cell subtypes, neutrophil:lymphocyte ratio [NLR], platelet:lymphocyte ratio [PLR], and monocyte:lymphocyte ratio [MLR]) and CA125 levels in endometriosis patients.

Methods: This study comprised 662 women who had undergone laparoscopic surgery and been pathologically confirmed as having endometriosis and 83 patients pathologically confirmed with benign ovarian tumors. Related inflammatory factors in endometriosis complicated by infertility were analyzed via logistic regression analysis. Read More

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http://dx.doi.org/10.2147/TCRM.S232849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229864PMC

Differential blood count as triage tool in evaluation of pelvic masses.

Int J Gynecol Cancer 2020 Jun 2. Epub 2020 Jun 2.

Dana Farber Cancer Institute, Boston, Massachusetts, USA.

Objective: Triaging patients with presumptive ovarian cancer to the appropriate specialist may improve survival. Therefore, there is increasing interest in complementary diagnostic markers to the standard serum CA125. In patients with pelvic masses, we examined the ability of epidemiologic variables and preoperative differential blood counts to improve detection of ovarian cancer over CA125 alone. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001103DOI Listing

A case report for a diagnostic dilemma of a giant intra-abdominal cyst with an uncertain origin.

Authors:
Nern Hoong Kao

Int J Surg Case Rep 2020 6;71:374-377. Epub 2020 Feb 6.

Department of General Surgery, Changi General Hospital, Singapore. Electronic address:

Introduction: Giant intra-abdominal cystic lesions are seldom encountered and can post a diagnostic challenge pre-operatively. These often present as increasing abdominal size and from its mass effect.

Presentation Of Case: Here, we present a case of a 58 year-old gentleman with worsening bloating and abdominal distension. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.01.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322736PMC
February 2020

Use of Tranexamic Acid for the Treatment of Mittelschmerz in a Patient with Type 1 von Willebrand Disease and Recurrent Hemorrhagic Cysts.

J Obstet Gynaecol Can 2020 Mar 24. Epub 2020 Mar 24.

Department of Obstetrics and Gynecology, McGill University, Montréal, QC. Electronic address:

Background: Tranexamic acid reduces blood loss in patients with bleeding diatheses and is used in a number of gynaecologic and non-gynaecologic conditions.

Case: We discuss the case of a 27-year-old woman with type 1 von Willebrand disease, who presented with a two-year history of severe mittelschmerz secondary to recurrent hemorrhagic cysts. The patient refused oral contraception and reported that traditional analgesia did not significantly alleviate symptoms. Read More

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http://dx.doi.org/10.1016/j.jogc.2020.02.128DOI Listing

Effectiveness of acupuncture in polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2020 May;99(22):e20441

Center for Reproductive medicine.

Objective: To evaluate the effectiveness of acupuncture in reproductive-age females with polycystic ovary syndrome (PCOS).

Methods: We searched the Pubmed, Web of Science, Embase, Cochrane, China National Knowledge Infrastructure (CNKI), Wanfang Data, and Chongqing VIP databases for the relevant literature. The meta-analysis was performed with a random-effects model with RevMan 5. Read More

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http://dx.doi.org/10.1097/MD.0000000000020441DOI Listing