23,291 results match your criteria Ovarian Cysts


SERS-based detection of haptoglobin in ovarian cyst fluid as a point-of-care diagnostic assay for epithelial ovarian cancer.

Cancer Manag Res 2019 31;11:1115-1124. Epub 2019 Jan 31.

Laboratory of Bio-optical Imaging, Singapore Bioimaging Consortium, Agency for Science Technology and Research (ASTAR), Singapore,

Purpose: To evaluate haptoglobin (Hp) in ovarian cyst fluid as a diagnostic biomarker for epithelial ovarian cancers (EOCs) using surface-enhanced Raman spectroscopy (SERS)-based in vitro diagnostic assay for use in an intraoperative setting.

Methods: SERS-based method was used to detect and quantify Hp in archived ovarian cyst fluids collected from suspicious ovarian cysts and differentiate benign tumors from EOCs. The diagnostic performance of SERS-based assay was verified against the histopathology conclusions and compared with the results of CA125 test and frozen sections. Read More

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http://dx.doi.org/10.2147/CMAR.S185375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362937PMC
January 2019

Ovarian Reserve Reduction With Surgery Is Not Correlated With the Amount of Ovarian Tissue Inadvertently Excised at Laparoscopic Surgery for Endometriomas.

Reprod Sci 2019 Feb 14:1933719119828055. Epub 2019 Feb 14.

1 Department of Obstetrics and Gynecology, "Sapienza" University of Rome, Rome, Italy.

The aim of the present study was to evaluate the effect of laparoscopic cystectomy on ovarian reserve by means of anti-Müllerian hormone (AMH) serial measurements and to compare AMH values with the number of inadvertently removed follicles in histological specimens. Fifty-two women were enrolled: 34 patients with endometriomas (group 1) and 18 patients with other benign ovarian cysts (group 2). All patients underwent laparoscopic cystectomy performed by a single experienced surgeon. Read More

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http://dx.doi.org/10.1177/1933719119828055DOI Listing
February 2019

Fetal abdominal cysts: antenatal course and postnatal outcomes.

J Perinat Med 2019 Feb 14. Epub 2019 Feb 14.

Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, UK.

Background There is little information on which to base the prognostic counselling as to whether an antenatally diagnosed fetal abdominal cyst will grow or shrink, or need surgery. This study aims to provide contemporary data on prenatally diagnosed fetal abdominal cysts in relation to their course and postnatal outcomes. Methods Fetal abdominal cysts diagnosed over 11 years in a single centre were identified. Read More

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http://dx.doi.org/10.1515/jpm-2018-0311DOI Listing
February 2019

Reduced α-2,6 sialylation regulates cell migration in endometriosis.

Hum Reprod 2019 Feb 12. Epub 2019 Feb 12.

Département 'Développement, Reproduction et Cancer', Institut Cochin, INSERM U1016 (Professeur Batteux), Université Paris Descartes, Sorbonne Paris Cité, 22 Rue Méchain, Paris, France.

Study Question: Is endometriosis associated with aberrant sialylation patterns and what is the potential impact of such anomalies on cell migratory properties?

Summary Answer: The reduced α-2,6 sialylation patterns in the peritoneal fluid of endometriosis-affected women and in stromal and epithelial cells from endometriotic lesions could be associated with enhanced cell migration.

What Is Known Already: Endometriosis is considered to be a benign disease although, like cancer, it has the characteristic of being an invasive disease with cells that have an enhanced capacity to migrate. Aberrant sialylation has been reported in various malignancies and it has been linked to tumour invasion and metastasis. Read More

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http://dx.doi.org/10.1093/humrep/dey391DOI Listing
February 2019
1 Read

Effect of laparoscopic endometrioma cystectomy on anti-Müllerian hormone (AMH) levels.

Gynecol Endocrinol 2019 Feb 7:1-4. Epub 2019 Feb 7.

a Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital , Capital Medical University , Beijing , China.

Objective: To investigate temporary or long-term changes of AMH after laparoscopic endometrioma cystectomy and its dependency on characteristics of endometriomas.

Methods: One hundred and seventy-one women, open-labeled prospective study; five groups divided according age ≤/> 35, uni-/bilateral, cyst ≤/> 7 cm, coagulation/suture surgery, stage III/IV; between- and within-group analyses after 1, 3, 6, and 12 months.

Results: After 12 months, compared to pretreament, AMH decreased significantly for patients with bilateral cysts, cyst size >7 cm and endometriosis stage IV. Read More

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http://dx.doi.org/10.1080/09513590.2018.1549220DOI Listing
February 2019
1 Read

Heavy black tea consumption and elevated CA 19-9 and CA 125 levels. A case report on a patient with ovarian endometriotic cysts.

Gynecol Endocrinol 2019 Feb 6:1-3. Epub 2019 Feb 6.

a Department of Gynecology and Gynecological Oncology, Gynecologic Cancer Unit Comprehensive Cancer Center Medical University of Vienna, Vienna , Austria.

In this case report, we present a case of false positive CA 19-9 and CA 125 levels in a patient with suspected endometriotic cysts. The patient is a 34-year-old nulliparous woman with heavy black tea consumption and elevated CA 19-9 and CA 125 levels. After discontinuation of black tea intake and careful exploration of other possible factors, CA 19-9 and CA 125 levels dropped markedly. Read More

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https://www.tandfonline.com/doi/full/10.1080/09513590.2018.1
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http://dx.doi.org/10.1080/09513590.2018.1564743DOI Listing
February 2019
2 Reads

Ultrasonographically diagnosed dermoid cysts do not influence ovarian stimulation response in an in vitro fertilization cycle.

Gynecol Endocrinol 2019 Feb 6:1-6. Epub 2019 Feb 6.

a Hospital Universitari Dexeus , Barcelona , Spain.

To determine if patients with a DC respond similarly to ovarian stimulation when compared to patients without a DC. Infertility patients with a DC that underwent IVF between January 2009 and December 2016 were included. A cystic mass with mixed echogenicity, internal echoes similar to thick bands, fatty-fluid level, or an echogenic tubercle with acoustic shadow (Rokitansky nodule) within two years of the cycle characterized the diagnosis. Read More

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http://dx.doi.org/10.1080/09513590.2018.1563887DOI Listing
February 2019
1 Read

Hyperreactio luteinalis and hypothyroidism: A case report.

Case Rep Womens Health 2019 Jan 29;21:e00094. Epub 2018 Dec 29.

Research Committee, "Dr. Alberto Romo Caballero" School of Medicine, Universidad Autónoma de Tamaulipas, Tampico, Tamaulipas, Mexico.

We report a case of hyperreactio luteinalis (HL) and hypothyroidism diagnosed at 13 weeks of pregnancy. A 29-year-old woman with a spontaneous 13-week singleton pregnancy presented with hirsutism and a pelvic mass. Ultrasound showed a viable pregnancy compatible with the gestational age and multiple cystic lesions on both ovaries. Read More

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http://dx.doi.org/10.1016/j.crwh.2018.e00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350097PMC
January 2019
1 Read

Syzygium cumini (L.) Skeels improves metabolic and ovarian parameters in female obese rats with malfunctioning hypothalamus-pituitary-gonadal axis.

J Ovarian Res 2019 Feb 4;12(1):13. Epub 2019 Feb 4.

Departamento de Ciências Fisiológicas, Universidade Federal do Maranhão, São Luís, Maranhão, Brazil.

Background: Obesity is a chronic and multifactorial disease characterized by increased adipose tissue. In females, obesity leads to reduced ovulation and lower chances of conception in diseases like polycystic ovary syndrome, making it important to characterize complementary medicine to attenuate such deleterious effects. Therefore, the aim of this study was to assess the effects of a hydroethanolic extract from Syzigium cumini leaves in female reproductive impairments present in the obesity model of neonatal L-monosodium glutamate injection. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-019-0490-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360653PMC
February 2019
3 Reads

Endometriosis biomarkers: Will co-development in academia-industry partnerships result in new and robust noninvasive diagnostic tests?

Biol Reprod 2019 Feb 1. Epub 2019 Feb 1.

Department of Development and Regeneration, Biomedical Sciences Group, KU Leuven (University of Leuven), Belgium.

Endometriosis is an important gynecological disease, affecting 10% of reproductive age women, and associated with pain, infertility, reduced quality of life and high health economic cost. Except for ultrasound detection of ovarian endometriotic cysts, the gold standard for diagnosis is laparoscopy, leading to diagnostic delays of 5-10 years. Accurate noninvasive biomarkers are needed, especially for symptomatic women with a normal gynecological ultrasound, to triage them towards medical or surgical treatment and to monitor their treatment outcome. Read More

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http://dx.doi.org/10.1093/biolre/ioz016DOI Listing
February 2019
2 Reads

Univariate and classification analysis reveals potential diagnostic biomarkers for early stage ovarian cancer Type 1 and Type 2.

J Proteomics 2019 Mar 30;196:57-68. Epub 2019 Jan 30.

Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden. Electronic address:

Biomarkers for early detection of ovarian tumors are urgently needed. Tumors of the ovary grow within cysts and most are benign. Surgical sampling is the only way to ensure accurate diagnosis, but often leads to morbidity and loss of female hormones. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.01.017DOI Listing
March 2019
2 Reads

Immunophenotypic profile of leukocytes in hyperandrogenemic female rat an animal model of polycystic ovary syndrome.

Life Sci 2019 Mar 29;220:44-49. Epub 2019 Jan 29.

Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, United States of America; Women's Health Research Center, University of Mississippi Medical Center, United States of America. Electronic address:

The immune etiology of polycystic ovary syndrome (PCOS) is an intriguing area. However, whether there is alteration in the leukocyte populations in different tissues remain ambiguous.

Aim: To characterize the leukocyte populations of hyperandrogenemic female (HAF) rat tissues. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.048DOI Listing
March 2019
1 Read

An Unusual Presentation of Endometriosis as an Ileocolic Intussusception with Cecal Mass: A Case Report.

J Reprod Infertil 2018 Oct-Dec;19(4):247-249

Department of Pathology, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Bowel endometriosis affects about 3.8-37% of women with endometriosis diagnosis. Most of the time endometriosis involves the recto-sigmoid. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328977PMC
February 2019
1 Read

Role of a natural integrator based on lipoic acid, palmitoiletanolamide and myrrh in the treatment of chronic pelvic pain and endometriosis.

Minerva Ginecol 2019 Jan 28. Epub 2019 Jan 28.

3 Unit of Gynecology and Human Reproduction Physiopathology, Department of Obstetrics and Gynecology, S. Orsola Hospital, University of Bologna, Bologna, Italy.

Dysmenorrhea and chronic pelvic pain occur in a significantly higher percentage in women with endometriosis; this benign condition has an incidence ranging from 5 to 10% in the general population, while 35% to 50% of infertile women are affected. Treatment of the symptoms demands integrated approaches with the use of anti-inflammatory substances or drugs and lifestyle changes, including attention to diet. The use of traditional anti-inflammatory drugs over the long term is not very successful because of the fear of side effects so they are almost always used with a short-term formula of 7-10 days when the woman's general condition becomes difficult to bear. Read More

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http://dx.doi.org/10.23736/S0026-4784.19.04384-3DOI Listing
January 2019
1 Read

Retrospective characterization of reproductive tract lesions in relation to age, parity, and contraception in captive suidae and tayassuidae.

Theriogenology 2019 Mar 18;127:137-144. Epub 2019 Jan 18.

Department of Veterinary Physiology and Pharmacology, 4466 TAMU Texas A&M University, College Station, TX, 77843, USA. Electronic address:

Reproductive management in zoos requires contraception or physical separation of sexes to ensure captive population viability, but information is sparse on the effects of parity, age, and contraceptive use on lifetime reproductive health in captive Suidae and Tayassuidae species. This retrospective study evaluated reproductive tissues and histories from babirusa (Babyrousa babyrussa), red river hog (Potamochoerus porcus), Visayan warty pig (Sus cebifrons), common warthog (Phacochoerus africanus), Vietnamese pot-bellied pig (Sus scrofa domesticus), domestic cross pig (Sus scrofa), Sunda island pig (Sus celebensis timoriensis), Eurasian boar (Sus scrofa), Bornean bearded pig (Sus barbatus), Ossabaw island hog (Sus scrofa domesticus), Guinea hog (Sus scrofa domesticus), Chacoan peccary (Catagonus wagneri), and collared peccary (Pecari tajacu). Age, parity, litter size, time-since-last-parturition, contraception exposure and type, and lesion prevalence were recorded. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.01.012DOI Listing
March 2019
2 Reads

Fertility After Ovarian Cystectomy: How Does Surgery Affect IVF/ICSI Outcomes?

Geburtshilfe Frauenheilkd 2019 Jan 17;79(1):72-78. Epub 2019 Jan 17.

Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Klinik und Poliklinik für Geburtshilfe und Frauengesundheit, Mainz, Germany.

For patients considering undergoing assisted reproductive techniques (ART), many concerns arise when persistent ovarian cysts are found. This large study aimed to determine how ovarian cyst removal affects success rates of IVF/ICSI therapies. 550 patients who underwent an IVF/ICSI treatment between 2002 and 2011 with a persistent ovarian cyst ≤ 5 cm before treatment were analyzed retrospectively. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0767-6722
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http://dx.doi.org/10.1055/a-0767-6722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336490PMC
January 2019
2 Reads

Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome.

J Ovarian Res 2019 Jan 21;12(1). Epub 2019 Jan 21.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Objective: The aim of this study was to determine the effect of vitamin D and probiotic co-administration on mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome (PCOS).

Methods: This randomized, double-blinded, placebo-controlled clinical trial was carried out on 60 subjects, aged 18-40 years old. Subjects were randomly allocated to take either 50,000 IU vitamin D every 2 weeks plus 8 × 10 CFU/day probiotic (n = 30) or placebo (n = 30) for 12 weeks. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-019-0480-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340184PMC
January 2019
5 Reads

Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome.

Mol Med Rep 2019 Mar 17;19(3):2220-2230. Epub 2019 Jan 17.

Department of Reproductive Medicine, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China.

Polycystic ovary syndrome (PCOS) is a condition in which a woman's levels of the sex hormones (estrogen and progesterone) are out of balance, leading to the growth of ovarian cysts. PCOS can affect the menstrual cycle, fertility, cardiac function and even appearance of women. Therefore, we aimed to explore the genetic polymorphism of the melatonin receptors 1A and 1B in obese patients with PCOS to identify a new theoretical basis for its treatment. Read More

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http://dx.doi.org/10.3892/mmr.2019.9872DOI Listing
March 2019
5 Reads

Treatment of ovarian endometrial cysts in the context of recurrence and fertility.

Adv Clin Exp Med 2019 Jan 15. Epub 2019 Jan 15.

Department of Gynecology, Endocrinology and Gynecologic Oncology, Pomeranian Medical University, Szczecin, Poland.

An approach to ovarian endometrial cysts has changed considerably during recent years, especially in regard to treatment of recurrent endometriosis, fertility sparing and infertility management. Surgical treatment is the primary therapeutic option. The most efficient types of treatment are radical procedures involving adhesiolysis, removal of the cyst along with its capsule and any remaining endometriotic foci. Read More

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http://dx.doi.org/10.17219/acem/90767DOI Listing
January 2019
2 Reads

Management options for a patient with squamous cell carcinoma arising in a mature cystic teratoma of the ovary.

J Exp Ther Oncol 2019 Jan;13(1):45-48

Lenox Hill Hospital, Northwell Health, Department of OBGYN, New York, NY, USA.

Objective: Mature cystic teratomas, also referred to as dermoid cysts, are one of the commonly occurring ovarian germ cell tumors. Malignant transformation of a germ cell tumor occurs approximately 1-2% of the time. Treatment options vary by stage and are not well outlined in the literature. Read More

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January 2019
2 Reads

Epithelial Mutations in Endometriosis: Link to Ovarian Cancer.

Endocrinology 2019 Jan 17. Epub 2019 Jan 17.

Division of Reproductive Medicine in Science, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University.

While epidemiologic and histopathologic associations between endometriosis and epithelial ovarian cancer have been reported, the underlying molecular and cellular mechanisms are not well understood. Recent publications suggest a possible genetic link. Driver mutations in PIK3CA, KRAS, ARID1A and other genes have been found in the epithelium of intrauterine endometrial tissue, ovarian and extraovarian pelvic endometriosis tissue, ovarian cancers associated with endometriosis (clear cell and endometrioid type) and other epithelial ovarian cancers. Read More

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https://academic.oup.com/endo/advance-article/doi/10.1210/en
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http://dx.doi.org/10.1210/en.2018-00794DOI Listing
January 2019
6 Reads

Antioxidant effects of calligonum extract on ovarian tissue of PCO model: An experimental study.

Int J Reprod Biomed (Yazd) 2018 Oct;16(10):641-648

Department of Anatomy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Background: Polycystic ovary syndrome (PCO) is one of the most common reasons for infertility. Calligonum as a plant possess some of the important antioxidants that can decrease oxidative stress.

Objective: The effects of treatment with Calligonum as an antioxidant on ovary tissue of a PCO mouse model. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314641PMC
October 2018
1 Read

Differences in Origin and Outcome of Intra-Abdominal Cysts in Male and Female Fetuses.

Fetal Diagn Ther 2019 Jan 10:1-9. Epub 2019 Jan 10.

Erasmus MC, University Medical Center Rotterdam, Department of Obstetrics and Gynecology, Division of Obstetrics and Prenatal Medicine, Rotterdam, The Netherlands.

Objective: To investigate the origin and outcome in a cohort of male and female fetuses with intra-abdominal cysts, in order to provide recommendations on management and to improve prenatal counselling.

Methods: From 2002 to 2016, intra-abdominal cysts were detected by ultrasound in 158 fetuses. Cases with an umbilical vein varix were excluded. Read More

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http://dx.doi.org/10.1159/000495506DOI Listing
January 2019
3 Reads

Detection and differentiation of two koala gammaherpesviruses using high resolution melt (HRM) analysis reveals differences in viral prevalence and clinical associations in a large study of free-ranging koalas.

J Clin Microbiol 2019 Jan 9. Epub 2019 Jan 9.

Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Building 400, Parkville, 3052. VIC, Australia.

The iconic koala () is host to two divergent gammaherpesviruses, phascolarctid gammaherpesviruses 1 and 2 (PhaHV-1, and -2), but the clinical significance of the individual viruses is unknown and current diagnostic methods are unsuitable for differentiating between the viruses in large-scale studies. To address this, we modified a pan-herpesvirus nested-PCR to incorporate high resolution melt analysis. We applied this assay in a molecular epidemiological study of 810 koalas from disparate populations across Victoria, Australia, including isolated island populations. Read More

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http://jcm.asm.org/lookup/doi/10.1128/JCM.01478-18
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http://dx.doi.org/10.1128/JCM.01478-18DOI Listing
January 2019
2 Reads

Polycystic Ovarian Condition May Be a Risk Factor for Ovarian Tumor Development in the Laying Hen Model of Spontaneous Ovarian Cancer.

J Immunol Res 2018 25;2018:2590910. Epub 2018 Nov 25.

Department of Pathology, Rush University Medical Center, Chicago, IL, USA.

Chronic inflammation and long-standing oxidative stress are potential predisposing factors for developing malignancies, including ovarian cancer (OVCA). Information on the association of ovarian chronic abnormal conditions, including polycystic ovarian syndrome (PCOS), with the development of OVCA is unknown. The goal of this study was to examine if polycystic ovarian conditions are associated with OVCA development. Read More

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http://dx.doi.org/10.1155/2018/2590910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286744PMC
January 2019
9 Reads

GATA6 expression promoted by an active enhancer may become a molecular marker in endometriosis lesions.

Am J Reprod Immunol 2018 Dec 27:e13078. Epub 2018 Dec 27.

Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Japan.

Problem: Genome-wide profiling of DNA methylation in endometriotic cells has shown a distinct facet of epigenetic backgrounds; however, specific DNA methylation sites responsible for aberrant gene expression in endometriosis were unknown. Are there specific endometriosis-associated DNA methylations that can be used as molecular markers in endometriosis lesions?

Method Of Study: This study used endometriotic tissues from the chocolate cyst lining of the ovaries of patients with endometriosis, and endometrial tissues from disease-free patients. For analysis, stromal cells were collected from endometrial and endometriotic tissues. Read More

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http://dx.doi.org/10.1111/aji.13078DOI Listing
December 2018
2 Reads

Disrupted iron metabolism in peritoneal fluid may induce oxidative stress in the peritoneal cavity of women with endometriosis.

Ann Agric Environ Med 2018 Dec 11;25(4):587-592. Epub 2017 Jul 11.

Department of Oncological Gynecology and Gynecology, Medical University of Lublin.

Introduction: Data on the possible role of peritoneal fluid free radical-mediated oxidative damage in the pathogenesis of endometriosis still remains inconsistent. The aim of the study was to determine iron metabolism markers and their influence on oxidative stress arameters in the peritoneal fluid of women with endometriosis.

Material And Methods: 110 women with endometriosis and 119 patients with benign ovarian cysts were included in the study. Read More

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http://dx.doi.org/10.26444/aaem/75802DOI Listing
December 2018
3 Reads

Levels of selected cytokines and acute-phase proteins in the serum of dairy cows with cystic ovarian disease and those in follicular and luteal phases of normal ovarian cycle.

Res Vet Sci 2018 Dec 19;123:20-25. Epub 2018 Dec 19.

Department and Clinic of Animal Reproduction, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Głęboka 30, 20-612 Lublin, Poland.

The aim of the study was to evaluate the concentration of selected cytokines (tumor necrosis factor [TNFα], interleukin [IL]-6, IL-10) and acute-phase proteins (APPs; haptoglobin [Hp] and serum amyloid A [SAA]) in the serum of cows with follicular and luteal ovarian cysts and in those in the follicular and luteal phases of a physiological ovarian cycle. The study was conducted on 24 Holstein-Friesian (HF) cows: eight cows in the follicular phase of the cycle; the same cows after 10 days when they were in the luteal phase; eight cows with follicular cysts; and eight cows with luteal cysts. Levels of progesterone, 17β-estradiol, TNF-α, IL-6, IL-10, SAA, and Hp were evaluated in the serum of all examined cows. Read More

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http://dx.doi.org/10.1016/j.rvsc.2018.12.007DOI Listing
December 2018
1 Read

Pelvic Pain in Adolescents.

Semin Reprod Med 2018 Mar 19;36(2):116-122. Epub 2018 Dec 19.

Department of Obstetrics and Gynecology, University of Michigan Health System, Ann Arbor, Michigan.

Dysmenorrhea and noncyclic pelvic pain (chronic pelvic pain) are common in adolescents. The evaluation of teens with dysmenorrhea or chronic pelvic pain is aimed to diagnose possible gynecologic conditions (endometriosis, pelvic inflammatory disease, ovarian cysts, and obstruction of the reproductive tract) and nongynecologic conditions (irritable bowel syndrome, interstitial cystitis, and myofascial pain). The management of chronic pelvic pain in adolescents is often more complex than in adult women because both the adolescent and her parents are counseled and addressed, and her long-term emotional and physical health, fertility, and sexuality are considered. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676088
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http://dx.doi.org/10.1055/s-0038-1676088DOI Listing
March 2018
4 Reads

The Recurrent t(11;22)(q23;q11.2) Can Occur as a Post-Zygotic Event.

Cytogenet Genome Res 2018 14;156(4):185-190. Epub 2018 Dec 14.

The AT-rich repeat on chromosome 22q11.2 is known to be involved in the recurrent constitutional t(11;22)(q23;q11.2). Read More

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http://dx.doi.org/10.1159/000494648DOI Listing
February 2019
2 Reads

An Improved Dehydroepiandrosterone-Induced Rat Model of Polycystic Ovary Syndrome (PCOS): Post-pubertal Improve PCOS's Features.

Front Endocrinol (Lausanne) 2018 4;9:735. Epub 2018 Dec 4.

Department of Science in Korean Medicine and Brain Korea 21 Plus Program, Graduate School, Kyung Hee University, Seoul, South Korea.

Complete animal models investigating the pathogenesis and treatment of polycystic ovarian syndrome (PCOS) are not completely established. Although dehydroepiandrosterone (DHEA)-induced pre-pubertal rat model for PCOS has been widely used, the model exhibits weaknesses such as decreased ovary weight. Here, we report an innovative DHEA-induced PCOS model that addresses limitations of the pre-pubertal model. Read More

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http://dx.doi.org/10.3389/fendo.2018.00735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288467PMC
December 2018
1 Read

Overview of perimenopausal contraception.

Authors:
J Bitzer

Climacteric 2019 Feb 18;22(1):44-50. Epub 2018 Dec 18.

a Frauenklinik , Universitätsspital Basel , Basel , Switzerland.

The perimenopause is accompanied by important biological and psychosocial changes. The choice of contraceptive methods for women in the perimenopause, none of which is limited by age alone, will depend on the efficacy, safety, tolerability, and potential benefit of each method in relation to the biopsychosocial profile of the individual woman. Copper intrauterine devices are highly effective in the typical user and are a very safe method with, in general, good tolerability but are of limited use in women with heavy menstrual bleeding and subserous myomata. Read More

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http://dx.doi.org/10.1080/13697137.2018.1540566DOI Listing
February 2019
3 Reads

A human ciliopathy with polycystic ovarian syndrome and multiple subcutaneous cysts: A rare case report.

Medicine (Baltimore) 2018 Dec;97(50):e13531

Department of Infectious Diseases and the Center for Liver Diseases, Peking University First Hospital, Beijing.

Rationale: Ciliopathies is a group of clinically and genetically overlapping disorders due to cilia abnormalities and multiple organ systems are involved in.

Patient Concerns: We present a young female patient who showed renal function impairment, Caroli syndrome (CS), liver cirrhosis, polycystic ovarian syndrome, and multiple subcutaneous cysts.

Diagnoses: The patient was diagnosed with ciliopathy according to the clinical manifestations and whole-genome sequencing. Read More

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http://dx.doi.org/10.1097/MD.0000000000013531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320131PMC
December 2018
7 Reads

Proteomics in the Diagnosis of Endometriosis: Opportunities and Challenges.

Authors:
Simone Ferrero

Proteomics Clin Appl 2018 Dec 17:e1800183. Epub 2018 Dec 17.

Academic Unit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Largo Paolo Daneo 3, 16132, Genova, Italy.

The non-surgical diagnosis of endometriosis is still challenging for the clinician. Ultrasonography and magnetic resonance imaging can be used to diagnose ovarian endometriotic cysts and deep infiltrating endometriosis; but their performance is poor in the diagnosis of initial stages of endometriosis. CA-125 and other serum markers (such as CA 19-9, serum protein PP14, interleukins, and angiogenetic factors) have been measured in women with endometriosis but they are not reliable for the diagnosis of the disease. Read More

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http://doi.wiley.com/10.1002/prca.201800183
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http://dx.doi.org/10.1002/prca.201800183DOI Listing
December 2018
5 Reads

The Extracellular Matrix of Ovarian Cortical Inclusion Cysts Modulates Invasion of Fallopian Tube Epithelial Cells.

APL Bioeng 2018 11;2(3). Epub 2018 Apr 11.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.

A growing body of research supports the idea that the fallopian tube epithelium (FTE) is the precursor for most high-grade serous ovarian canacers (HGSOC) but that the ovary plays a critical role in tumor metastasis. Cortical inclusion cysts (CICs) in the ovarian cortex have been hypothesized to create a niche environment that plays a role in HGSOC progression. Through histological analysis of pathology samples from human ovaries, we determined that collagen I and III were elevated near CICs and that the collagen fibers in this dense region were oriented parallel to the cyst boundary. Read More

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http://dx.doi.org/10.1063/1.5022595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294138PMC
April 2018
2 Reads

Impact of variants on type-2 diabetes risk genes identified through genomewide association studies in polycystic ovary syndrome: a case-control study.

J Genet 2018 Dec;97(5):1213-1223

Prince Fahd Bin Sultan Research Chair, Using Advance Technology for Diseases Detection and Treatment, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in females, and is associated with altered metabolic processes in particular insulin resistance and diabetes mellitus. PCOS shares with type-2 diabetes (T2D) a number of features, including beta cell dysfunction, impaired glucose tolerance and dyslipidaemia. Recently, genomewide association studies (GWAS) have reported a number of genes with reproducible associations and susceptibilities to T2D. Read More

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December 2018
1 Read

Painless ovarian tumor mimics ovarian cancer with all ligaments spontaneously detached: A case report.

Taiwan J Obstet Gynecol 2018 Dec;57(6):894-896

Department of Obstetrics and Gynecology, Tri-service General Hospital, National Defense Medical Center, Taipei, Taiwan. Electronic address:

Objective: Ovarian tumor is a frequently encountered gynecological disease. The tumor is usually anchored by a pedicle. In rare cases, it may detach and derive nourishment from other abdominal structures to which it adheres. Read More

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http://dx.doi.org/10.1016/j.tjog.2018.10.022DOI Listing
December 2018
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Risk Factors for Strangulated Ovarian Hernia in Female Infants: the Role of Ovarian Volume.

Curr Med Sci 2018 Dec 7;38(6):1032-1037. Epub 2018 Dec 7.

Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

The risk factors associated with strangulated ovarian hernia (SOH) in female patients (<1 year old) were identified. A retrospective analysis was conducted regarding the data from 2006 to 2017. The patients were divided into 2 groups: SOH group (n=9) and non-SOH group (n=23). Read More

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http://link.springer.com/10.1007/s11596-018-1980-4
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http://dx.doi.org/10.1007/s11596-018-1980-4DOI Listing
December 2018
23 Reads

An unusual cause of acute surgical abdomen: benign multicystic peritoneal mesothelioma associated with adenomatous tumor.

Rom J Morphol Embryol 2018 ;59(3):971-976

Department of Human Anatomy, University of Medicine and Pharmacy of Craiova, Romania;

Benign multicystic peritoneal mesothelioma (BMPM) is a rare disease that primarily affects fertile women with previous abdominal surgery. BMPM associated with adenomatous tumor is a single case report, according to our opinion. The patient had a history of abdominal surgery nine years ago for ovarian cysts. Read More

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January 2019
2 Reads

A clinically functioning gonadotroph adenoma presenting with abdominal pain, ovarian hyperstimulation and fibromatosis.

Endocrinol Diabetes Metab Case Rep 2018 Dec 11;2018. Epub 2018 Dec 11.

Southmead Hospital, North Bristol NHS Trust, Westbury-on-Trym, Bristol, UK.

Pituitary adenomas can be classified as functioning or non-functioning adenomas. Approximately 64% of clinically non-functioning pituitary adenomas are found to be gonadotroph adenomas on immunohistochemistry. There are reported cases of gonadotroph adenomas causing clinical symptoms, but this is unusual. Read More

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http://dx.doi.org/10.1530/EDM-18-0123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300858PMC
December 2018
6 Reads

[Acute Pelvic pain in women-gynecological causes].

Radiologe 2019 Feb;59(2):126-132

Universitätsinstitut für Radiologie, Universitätsklinikum der Paracelsus Medizinischen Privatuniversität, Müllner Hauptstraße 48, 5020, Salzburg, Österreich.

Background: Acute pelvic pain in women may be due to gynecological, gastrointestinal, and urinary tract disorders. Ectopic pregnancy (EP), pelvic inflammatory disease (PID), and ruptured ovarian cysts are the most common gynecological causes for acute pelvic pain and their diagnosis can be challenging.

Methods: Patient history, clinical examination, and blood tests as well as patient age and potential pregnancy status help to establish the correct diagnosis. Read More

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http://link.springer.com/10.1007/s00117-018-0475-4
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http://dx.doi.org/10.1007/s00117-018-0475-4DOI Listing
February 2019
21 Reads

Risk Model in Women with Ovarian Cancer Without Mutations.

Open Med (Wars) 2018 25;13:565-574. Epub 2018 Nov 25.

Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland.

Ovarian cancer is characterised by the greatest mortality among all tumors of the reproductive tract. This study included 246 patients which consisted of 136 women with ovarian cancer without genetic mutation and 110 women with benign ovarian cysts. We created two mathematical logic models containing positive and negative risk factors of ovarian cancer such as: age at last menstruation cycle, patient age, OC, HRT, smoking, education status, and alcohol consumption. Read More

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http://dx.doi.org/10.1515/med-2018-0084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272051PMC
November 2018
1 Read

Risk factors related to the recurrence of endometrioma in patients with long-term postoperative medical therapy.

Ginekol Pol 2018;89(11):611-617

Department of Obstetrics and Gynecology, Pusan National University School of Medicine Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

Objectives: The purpose of this study was to identify clinical risk factors for the recurrence of ovarian endometrioma after ovarian cystectomy in Korean women with long-term postoperative medical therapy.

Material And Methods: A total of 134 patients who were surgically treated for endometriotic cysts at Pusan National University Hospital were included in this retrospective study. All patients received long-term postoperative medical treatment for at least 12 months after the first-line conservative surgery. Read More

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http://dx.doi.org/10.5603/GP.a2018.0105DOI Listing
January 2018
2 Reads

Follicular fluid humanin concentration is related to ovarian reserve markers and clinical pregnancy after IVF-ICSI: a pilot study.

Reprod Biomed Online 2019 Jan 23;38(1):108-117. Epub 2018 Nov 23.

Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, No.13 Hang Kong Road, Wuhan Hubei 430030, China; Reproductive Medicine Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Research Question: Is humanin present in the human ovary and follicular fluid? What relationship exists between humanin concentration in the follicular fluid and ovarian reserve and clinical outcomes after IVF and intracytoplasmic sperm injection (ICSI)?

Design: Follicular fluid samples were collected from 179 patients undergoing their first IVF or ICSI cycle during oocyte retrieval. Ovarian tissues were collected from two patients undergoing surgery for ovarian cysts. Ovarian humanin localization was analysed using immunofluorescence staining. Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.11.002DOI Listing
January 2019
12 Reads
3.015 Impact Factor

Genital Tract Pathology in Female Pet Guinea Pigs (Cavia porcellus): a Retrospective Study of 655 Post-mortem and 64 Biopsy Cases.

J Comp Pathol 2018 Nov 19;165:13-22. Epub 2018 Oct 19.

Institute of Veterinary Pathology, Freie Universität Berlin, Robert-von-Ostertagstrase 15, Germany. Electronic address:

Disorders of the female genital tract are among the most common disorders in pet guinea pigs (Cavia porcellus); however, knowledge of many aspects of these disorders is sparse, especially regarding their incidence and age distribution. Ovarian cysts, as the most common genital tract disorder in guinea pigs, have been investigated in detail; however, information on the nature of these cysts is inconsistent. The present study reviewed genital tract disorders occurring within 655 full post-mortem examinations of intact female pet guinea pigs and 64 female genital tract biopsies examined over a 22. Read More

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http://dx.doi.org/10.1016/j.jcpa.2018.09.001DOI Listing
November 2018
1 Read

A comprehensive interventional program for promoting eating behaviors in adolescent girls with polycystic ovarian syndrome (PCOS): protocol for a mixed methods study.

Reprod Health 2018 Dec 4;15(1):197. Epub 2018 Dec 4.

Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder among women. Inappropriate eating behaviors are some of the most important risk factors for obesity in all age groups. Therefore, performing comprehensive culturally sensitive interventions for modification of eating behaviors as a useful affordable strategy seems necessary. Read More

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http://dx.doi.org/10.1186/s12978-018-0652-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278146PMC
December 2018
7 Reads

Impaired Localization of Claudin-11 in Endometriotic Epithelial Cells Compared to Endometrial Cells.

Reprod Sci 2018 Dec 4:1933719118811643. Epub 2018 Dec 4.

1 Department of Gynecology and Obstetrics, University of Giessen, Giessen, Germany.

Claudins are the major components of tight junctions and are often deregulated in human cancer, permitting escape of cancer cells along with the acquisition of invasive properties. Similarly, endometrial cells also show invasive capabilities; however, the role of tight junctions in endometriosis has only rarely been examined. In this study, we analyzed the protein expression and localization of claudin-7 and claudin-11 in human eutopic and ectopic endometrium and endometrial cell lines. Read More

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http://dx.doi.org/10.1177/1933719118811643DOI Listing
December 2018
2 Reads

Effects of ADIPOQ polymorphisms on PCOS risk: a meta-analysis.

Reprod Biol Endocrinol 2018 Dec 3;16(1):120. Epub 2018 Dec 3.

Department of gynaecology, Linyi Central Hospital, No.17 Jiankang Road of Yishui county, Linyi, 276400, Shandong, China.

Background: Whether adiponectin (ADIPOQ) polymorphisms are associated with the risk of polycystic ovary syndrome (PCOS) remain controversial. Therefore, we performed this study to better explore correlations between ADIPOQ polymorphisms and PCOS risk.

Methods: Literature retrieve was conducted in PubMed, Medline and Embase. Read More

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https://rbej.biomedcentral.com/articles/10.1186/s12958-018-0
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http://dx.doi.org/10.1186/s12958-018-0439-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278103PMC
December 2018
12 Reads

An incidental diagnosis of a giant paraovarian cyst in a female teenager: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13406

Department of Pediatrics.

Rationale: Paraovarian cysts (PCs) are cystic tumors that can be encountered between the ovarian hilum and the ovarian fimbria located within the mesosalpinx and broad ligament, being usually diagnosed within the 3rd and 4th decade of life.

Patient Concerns: We report the case of a 15-year-old female admitted in our clinic for consciousness loss, who was incidentally diagnosed with a giant pelvic cystic at ultrasound.

Diagnoses: The magnetic resonance image showed a cystic mass of 170/140/85 mm, suggesting an origin from the left ovary, reaching the subhepatic area. Read More

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http://dx.doi.org/10.1097/MD.0000000000013406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283066PMC
November 2018
5 Reads
5.723 Impact Factor

Managing polycystic ovary syndrome in primary care.

Singapore Med J 2018 Nov;59(11):567-571

Department of Endocrinology, Changi General Hospital, Singapore.

Polycystic ovary syndrome (PCOS) presents with a spectrum of conditions resulting from androgen excess, anovulation and metabolic syndrome. Patients with PCOS may see their primary care physicians for various presentations, including hirsutism, acne, menstrual irregularities, infertility, obesity, and psychiatric disorders such as anxiety and depression. Management of these patients should include screening for Type 2 diabetes mellitus, dyslipidaemia and hypertension. Read More

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http://dx.doi.org/10.11622/smedj.2018135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250763PMC
November 2018
3 Reads