27,587 results match your criteria Ovarian Cysts


Benefits of Laparoscopic Surgery for Bleeding Events in Patients with Implantable Left Ventricular Assist Devices during Antithrombotic Therapy.

Gynecol Minim Invasive Ther 2022 Apr-Jun;11(2):110-113. Epub 2022 May 4.

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Hemorrhagic ovarian cysts (HOCs), a common gynecological disease causing intraabdominal bleeding, can be life threatening in patients undergoing antithrombotic therapy, especially those with left ventricular assist device (LVAD) implantation under strong antithrombotic therapy. We encountered three postLVAD implantation cases with intraabdominal bleeding due to suspected HOCs, which required surgery for hemostasis. Such patients are not only at a higher risk of bleeding but also have restrictions in available surgical incision sites to avoid damaging the LVAD driveline located underneath the abdominal wall. Read More

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Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian Syndrome.

Biomedicines 2022 Jun 2;10(6). Epub 2022 Jun 2.

Division of Gynecology and Obstetrics, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.

Polycystic ovary syndrome (PCOS) is an endocrine systemic disorder mainly characterized by a hormonal and metabolic disbalance that leads to oligo/anovulation, hyperandrogenism and the formation of ovarian cysts. Despite the progress that has been reached in its diagnosis and management, little is known about the molecular mechanisms and signaling pathways underlying the pathogenic mechanisms. In this sense, recent research has suggested that the influence of multiple factors, including age, environment, lifestyle and the disease state environment can change the clinical presentation of PCOS via epigenetic modifications. Read More

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Laparoscopic Treatment of Benign Adnexal Masses During Pregnancy: A Comprehensive Evaluation of Treatment Basics, Efficacy and Surgical Techniques.

Surg Technol Int 2022 Jun 23;40. Epub 2022 Jun 23.

Department of Minimally Invasive Surgery Unit of Centro Hospitalar Universitário do Porto, Porto, Portugal.

This review summarizes the evidence-based recommendations for how to approach and laparoscopically treat adnexal masses during pregnancy. We conducted a comprehensive review of studies related to the laparoscopic management of adnexal masses during pregnancy. Selected studies were independently reviewed by two authors. Read More

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[Neonatal bilateral ovarian cystadenoma: Conservative or surgical treatment?]

Andes Pediatr 2022 Apr;93(2):253-258

Instituto Mexicano del Seguro Social, Ciudad de México, Mexico.

Introduction: Bilateral complex ovarian cysts in newborns are rare and their reporting becomes imperative to in crease knowledge about the best therapeutic management.

Objective: To describe the clinical case of a newborn with a diagnosis of bilateral complex ovarian cysts and to discuss the conditions for conservative or surgical management according to the ultrasound characteristics of the cyst.

Clinical Case: At 35 weeks of gestational age, prenatal ultrasound identified the presence of cystic masses in both adnexa, so it was decided to interrupt the pregnancy by cesarean section at 37 weeks. Read More

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Extreme elevation of CA 19-9 levels in mature cystic teratoma without any complications: A case report.

Ann Med Surg (Lond) 2022 Jun 18;78:103803. Epub 2022 May 18.

Department of Obstetrics and Gynecology, Medical School of Jeju National University, Jeju National University Hospital, Aran 13gil 15 (Ara-1Dong), Jeju City, Jeju Self-Governing Province, 63241, South Korea.

Introduction And Importance: Carbohydrate antigen 19-9 (CA 19-9) can be increased in benign ovarian cysts, but extreme elevation is rare.

Case Presentation: We present a case of a mature cystic teratoma with extremely elevated CA 19-9 levels. After ovarian cystectomy, the level of CA 19-9 was decreased. Read More

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Adverse Effects of Polycystic Ovarian Syndrome on Pregnancy Outcomes in Women With Frozen-Thawed Embryo Transfer: Propensity Score-Matched Study.

Front Endocrinol (Lausanne) 2022 6;13:878853. Epub 2022 Jun 6.

Department of Traditional Chinese Medicine Gynecology, Changhai Hospital, Shanghai, China.

Purpose: This work aimed to evaluate the adverse effect of polycystic ovary syndrome (PCOS) on pregnancy outcomes of singletons after vitrification in women with frozen-thawed embryo transfer (FET).

Methods: Patients with/without PCOS who underwent FET from January 2013 and December 2018 were included. Propensity score matching (PSM) was used to reduce the influence of bias. Read More

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Extremely high serum CA19-9 level along with elevated D-dimer in assisting detection of ruptured ovarian endometriosis.

Ann Med 2022 Dec;54(1):1444-1451

Department of Obstetrics and Gynecology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Background: To clarify clinical importance of serum CA19-9, CA-125, and plasma D-dimer (D-D) levels in detecting spontaneously ruptured ovarian endometriosis (OE).

Materials And Methods: We retrospectively examined 173 patients with endometriosis out of 735 cases of OE between 2013 and 2019. Among these, 21 cases were diagnosed as "spontaneously ruptured" after surgery, while the remaining cases were unruptured. Read More

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December 2022

Prevalence and associated risk factors for mental health problems among patients with polycystic ovary syndrome in Bangladesh: A nationwide cross-Sectional study.

PLoS One 2022 22;17(6):e0270102. Epub 2022 Jun 22.

Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh.

Background: Polycystic ovary syndrome (PCOS) is a common female reproductive endocrine problem worldwide. The prevalence of mental disorder is increasing among PCOS patients due to various physical, psychological, and social issues. Here we aimed to evaluate the mental health and associated factors among women suffering from PCOS in Bangladesh. Read More

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Vitamin D supplementation inhibits NF-kß signaling pathway in lean and obese women with PCOS.

Eur Rev Med Pharmacol Sci 2022 Jun;26(11):3973-3977

Pirivate Office, Şanlıurfa, Turkey.

Objective: This study aims at investigating the effect of vitamin D (VD) replacement therapy on serum nuclear factor-kappa β (NF-kβ) levels in both lean and obese women with Polycystic Ovary Syndrome (PCOS).

Patients And Methods: 50 women with PCOS with VD levels lower than 20 ng/mL were included in the study. Participants were equally divided into two groups, as lean and overweight/obese PCOS, according to their body mass index (BMI) values. Read More

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Long non-coding RNA-X-inactive specific transcript inhibits cell viability, and induces apoptosis through the microRNA-30c-5p/Bcl2-like protein 11 signaling axis in human granulosa-like tumor cells.

Bioengineered 2022 Jun;13(6):14107-14117

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.

The role of long noncoding RNAs (lncRNAs) is being actively explored in polycystic ovary syndrome (PCOS). Recent research has shown that long non-coding RNA (lncRNA) X-inactive Specific Transcript (XIST) is overexpressed in patients with PCOS and is associated with poor pregnancy outcomes. However, the precise function and mechanism of action of lncRNA XIST in PCOS are unknown. Read More

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Hair cortisol in polycystic ovary syndrome.

Sci Rep 2022 Jun 20;12(1):10309. Epub 2022 Jun 20.

Departamento de Bioquímica Clínica-Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 956 (1113), Junín, Buenos Aires, Argentina.

The aim of the study was to evaluate adrenal axis hyperactivation measuring hair cortisol levels, and its influence on the relationship among metabolic parameters, inflammation markers and androgens in adult women with PCOS. 44 women (18-34 years) with PCOS diagnosis and a control group of 49 healthy women (19-35 years) were included. In both gropus body mass index (BMI) was calculated and waist circumference (WC) was measured. Read More

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Association of Polycystic Ovary Syndrome Phenotypes With Adverse Pregnancy Outcomes After Fertilization/Intracytoplasmic Sperm Injection.

Front Endocrinol (Lausanne) 2022 3;13:889029. Epub 2022 Jun 3.

Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Shandong University, Jinan, China.

Objective: This study aims to evaluate the association between polycystic ovary syndrome (PCOS) phenotypes and adverse perinatal outcomes, comparing the characteristics, ovarian response, and assisted reproductive outcomes in patients with various PCOS phenotypes after fertilization (IVF)/intracytoplasmic sperm injection (ICSI).

Methods: This study comprised 6,732 patients who underwent the first cycle of IVF/ICSI treatment in our outpatient department from January 2017 to July 2018. Propensity score matching (PSM) was used in PCOS and non-PCOS groups to balance the influence of intergroup confounding factors. Read More

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Polycystic Ovary Syndrome Phenotype D Versus Functional Hypothalamic Amenorrhea With Polycystic Ovarian Morphology: A Retrospective Study About a Frequent Differential Diagnosis.

Front Endocrinol (Lausanne) 2022 2;13:904706. Epub 2022 Jun 2.

Clinical Division of Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.

The two most frequent causes of secondary amenorrhea are polycystic ovary syndrome (PCOS) and functional hypothalamic amenorrhea (FHA). Despite several studies showing differences in hormonal profile between these groups, the differential diagnosis remains challenging, in particular between FHA women with polycystic ovarian morphology (FHA-PCOM) and PCOS patients without hyperandrogenism (phenotype D, PCOS-D). In a retrospective case-control study, 58 clearly defined patients with FHA-PCOM were compared to 58 PCOS-D patients, matched 1:1 for age and BMI. Read More

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Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome.

Front Endocrinol (Lausanne) 2022 1;13:877807. Epub 2022 Jun 1.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Background: Women with polycystic ovary syndrome (PCOS) suffer from dysfunctional metabolism and studies have reported increased levels of tryptophan in patients with PCOS. However, the changes of downstream metabolites in tryptophan catabolism pathways remain unclear.

Methods: This is a cross-sectional study that included 200 PCOS patients and 200 control women who were recruited from the Reproductive Medicine Center of Peking University Third Hospital from October 2017 to June 2019. Read More

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PCOS and Role of Cumulus Gene Expression in Assessing Oocytes Quality.

Front Endocrinol (Lausanne) 2022 26;13:843867. Epub 2022 May 26.

Department of Obstetrics and Gynaecology, National University of Malaysia, Kuala Lumpur, Malaysia.

The global infertility rate has been declining from year to year. PCOS is one of the treatable accountable causes contributing to anovulatory infertility. Nevertheless, the success rate of treatments and live-birth outcomes especially involving assisted reproductive techniques is still not very promising. Read More

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The Effect of Sperm DNA Fragmentation on Fertilization Outcomes for Women With Polycystic Ovary Syndrome.

Front Endocrinol (Lausanne) 2022 27;13:822786. Epub 2022 May 27.

Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disease in reproductive women associated with poor pregnancy outcomes. In modern society, people pay more attention to the female factor, but it is uncertain whether sperm quality is another factor affecting pregnancy outcomes of patients with PCOS.

Method: The effect of sperm DNA fragmentation (SDF) on oocyte fertilization, embryonic development, and pregnancy outcomes for patients with PCOS who underwent fertilization (IVF) treatment was studied. Read More

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The role of insulin-like growth factor 2 mRNA binding proteins in female reproductive pathophysiology.

Reprod Biol Endocrinol 2022 Jun 15;20(1):89. Epub 2022 Jun 15.

Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, People's Republic of China.

Insulin-like growth factor 2 (IGF2) mRNA binding proteins (IMPs) family belongs to a highly conserved family of RNA-binding proteins (RBPs) and is responsible for regulating RNA processing including localization, translation and stability. Mammalian IMPs (IMP1-3) take part in development, metabolism and tumorigenesis, where they are believed to play a major role in cell growth, metabolism, migration and invasion. IMPs have been identified that are expressed in ovary, placenta and embryo. Read More

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Impact of the individual counseling program for polycystic ovarya syndrome management among university students: A prospective randomized controlled trial.

Niger J Clin Pract 2022 Jun;25(6):809-816

Obstetrics and Gynecology Department, Faculty of Medicine, Health Sciences of Afyonkarahisar University, Afyon, Turkey.

Background: Polycystic ovary syndrome (PCOS) is common in women of reproductive age.

Aim: This study aimed to investigate the impact of individual counseling program which had been designed from the transtheoretical model (TM) for students diagnosed with PCOS.

Patients And Methods: The study is a prospective randomized controlled trial. Read More

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A New Family with a Novel Mutation: Practicing Whole Exome Sequencing for Antenatal Diagnosis of Tetralogy of Fallot.

Mol Syndromol 2022 May 26;13(3):206-211. Epub 2022 Jan 26.

Diagnostic Center for Genetic Diseases, Koc University Hospital, Istanbul, Turkey.

which encodes a member of the ovarian tumor domain-containing deubiquitinating enzyme, has recently been associated with autosomal recessive intellectual disability syndrome with seizures and dysmorphic features. Here, we report one additional case with Tetralogy of Fallot (ToF), who has microcephaly and dysmorphic features along with renal parenchymal disease with simple cortical cysts. The family's first pregnancy was medically terminated due to antenatal diagnosis of ToF. Read More

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Effects of electroacupuncture on the expression of hypothalamic neuropeptide Y and ghrelin in pubertal rats with polycystic ovary syndrome.

PLoS One 2022 15;17(6):e0259609. Epub 2022 Jun 15.

Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.

Background: Polycystic ovary syndrome often starts in puberty, and its pathogenesis is not clear. This study aimed to explore the pathogenesis of pubertal polycystic ovary syndrome (PCOS) and assess the therapeutic effect of electroacupuncture on pubertal PCOS.

Methods: Dihydrotestosterone (DHT) was used to induce rat models of pubertal PCOS. Read More

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A rare case of highly differentiated follicular carcinoma in ovary with FGFR4 Gly388Arg polymorphism: a case report and literature review.

J Ovarian Res 2022 Jun 14;15(1):71. Epub 2022 Jun 14.

Department of Gynecologic Oncology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Background: Highly differentiated follicular carcinoma (HDFCO) is a rare form of struma-derived thyroid-type carcinoma in ovary, defined as ovarian struma spreading beyond ovary but consisting of benign thyroid tissues. No more than 30 cases of HDFCO have been reported since it was first recognized in 2008. The clinicopathologic and molecular features of HDFCO remain unclear up till now. Read More

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High androgen concentrations in follicular fluid of polycystic ovary syndrome women.

Reprod Biol Endocrinol 2022 Jun 14;20(1):88. Epub 2022 Jun 14.

UMR 85 Physiology of Reproduction and Behaviour, National Research Institute for Agriculture, Food and Environment (INRAE) Centre Val de Loire, 37380, Nouzilly, France.

Background: According to current definitions of Polycystic Ovary Syndrome (PCOS), hyperandrogenism is considered as a key element in the pathogenesis of this common endocrinopathy. However, until now, studies about ovarian androgen profile in women are very rare. Our aim was then to characterise the expression profile of the androgens in follicular fluid of 30 PCOS patients, and compare it to those of 47 Control women and 29 women with only polycystic ovary morphology on ultrasounds (ECHO group). Read More

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Patient-centered outcomes for gastrointestinal cancer care: a scoping review protocol.

BMJ Open 2022 Jun 14;12(6):e061309. Epub 2022 Jun 14.

Cancer Program, Sunnybrook Research Institute, Evaluative Clinical Sciences Platform, Toronto, Ontario, Canada

Introduction: Following a cancer diagnosis, patients and their caregivers face crucial decisions regarding goals of care and treatment, which have consequences that can persist throughout their cancer journey. To foster informed and value-driven treatment choices, evidence-based information on outcomes relevant to patients is needed. Traditionally, clinical studies have largely focused on a few concrete and easily measurable outcomes such as survival, disease progression and immediate treatment toxicities. Read More

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Plasma Complement C1q/tumor necrosis factor-related protein 15 concentration is associated with polycystic ovary syndrome.

PLoS One 2022 14;17(6):e0263658. Epub 2022 Jun 14.

Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Polycystic ovarian syndrome (PCOS) is a common poignant endocrine disorder affecting women, posing a close association with metabolic syndrome and obesity. Existing literature characterizes PCOS with deranged levels of several adipokines and myokines. CTRP15 is a paralogue of adiponectin, mainly expressed by skeletal muscles, and plays a key role in insulin, glucose, and lipid metabolism. Read More

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Proliferation of the Fallopian Tube Fimbriae and Cortical Inclusion Cysts: Effects of the Menstrual Cycle and the Levonorgestrel Intra-Uterine Contraceptive System.

Cancer Epidemiol Biomarkers Prev 2022 Jun 14. Epub 2022 Jun 14.

Northwell Health Cancer Institute, Lake Success, NY, United States.

Background: The objectives of this study were (i) to explore if differences in cell proliferation may help explain why most high-grade serous ovarian cancers (HGSOCs) arise in the fallopian tube fimbriae (FTF) rather than in ovarian cortical inclusion cysts (CICs); (ii) to compare premenopausal and postmenopausal FTF proliferation as a reason why the age-incidence of HGSOC increases at a slower rate after menopause; and (iii) to compare FTF proliferation in cycling women and women using the levonorgestrel intra-uterine contraceptive system (Lng-IUS) to see whether proliferation on the Lng-IUS was lower.

Methods: We studied 60 women undergoing a salpingo-oophorectomy. We used Ki67, paired-box gene 8 (PAX8, Müllerian marker) and calretinin (CAL, mesothelial marker) to study FTF and CIC proliferation. Read More

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The effect of medication on serum anti-müllerian hormone (AMH) levels in women of reproductive age: a meta-analysis.

BMC Endocr Disord 2022 Jun 14;22(1):158. Epub 2022 Jun 14.

Department of Reproductive Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.

Objective: The study aims to address whether serum anti-müllerian hormone (AMH) levels fluctuate in the short term after medication application, including oral contraceptives (OCs), metformin (MET), Gonadotropin-releasing hormone agonist (GnRH-a), dehydroepiandrosterone (DHEA), vitamin D (VD), clomiphene citrate (CC), and letrozole (LET).

Methods: Published literature from PubMed, Embase, and Cochrane central was retrieved up until 19 September 2021. A total of 51 self-control studies with an average Newcastle-Ottawa quality assessment scale (NOS) score of 6. Read More

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Regulatory Role and Potential Importance of GDF-8 in Ovarian Reproductive Activity.

Front Endocrinol (Lausanne) 2022 26;13:878069. Epub 2022 May 26.

Department of Pharmacy, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Growth differentiation factor-8 (GDF-8) is a member of the transforming growth factor-beta superfamily. Studies and have shown GDF-8 to be involved in the physiology and pathology of ovarian reproductive functions. experiments using a granulosa-cell model have demonstrated steroidogenesis, gonadotrophin responsiveness, glucose metabolism, cell proliferation as well as expression of lysyl oxidase and pentraxin 3 to be regulated by GDF-8 the mothers against decapentaplegic homolog signaling pathway. Read More

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The Reliability and Validity of the Malay Version of Polycystic Ovarian Syndrome Health-Related Quality of Life Questionnaire.

Front Endocrinol (Lausanne) 2022 26;13:848860. Epub 2022 May 26.

Department of Obstetrics and Gynaecology, Universiti Kebangsaan Malaysia (UKM) Medical Centre, Kuala Lumpur, Malaysia.

The Polycystic Ovary Syndrome Questionnaire is a reliable instrument for measuring health-related quality of life. This study aimed to develop a Malay version of the Polycystic Ovary Syndrome Questionnaire and to evaluate the health-related impact of Malaysian women with polycystic ovary syndrome. The participants were women who were diagnosed with polycystic ovary syndrome using Rotterdam criteria in a gynecology clinic. Read More

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Progress of Adipokines in the Female Reproductive System: A Focus on Polycystic Ovary Syndrome.

Front Endocrinol (Lausanne) 2022 26;13:881684. Epub 2022 May 26.

Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

Adipose tissue, one type of loose connective tissue in the human body, maintains the primary task of energy storage. Adipose tissue is not only an energy reservoir but also plays a vital role as the largest endocrine organ of the whole body releasing a variety of adipokines, which participate in many pathophysiological processes, such as energy metabolism regulation, glucose and lipid metabolism, and inflammation. Polycystic ovary syndrome (PCOS) is a disorder that mainly involves the female reproductive system, affecting women of childbearing age particularly. Read More

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Ovarian conservation in a patient with a large ovarian cyst and adnexal torsion - a confirmatory video with intravenous indocyanine green.

Fertil Steril 2022 Jun 9. Epub 2022 Jun 9.

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Freiburg, Germany.

Objective: To share our experience of intravenous indocyanine green (ICG) application during conservative ovarian surgery in a young patient with adnexal torsion, a large ovarian cyst, and apparent ovarian necrosis.

Design: This confirmatory video of ovarian reperfusion uses footage from the laparoscopic treatment and ICG application in a young patient with adnexal torsion and apparent necrosis.

Setting: Academic, multisite medical center. Read More

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