109,578 results match your criteria Ovarian Cancer


Combinatorial Synthesis to Identify a Potent, Necrosis-Inducing Rhenium Anticancer Agent.

Inorg Chem 2019 Feb 22. Epub 2019 Feb 22.

Department of Chemistry and Chemical Biology , Cornell University , Ithaca , New York 14853 , United States.

Combinatorial synthesis can be applied for developing a library of compounds that can be rapidly screened for biological activity. Here, we report the application of microwave-assisted combinatorial chemistry for the synthesis of 80 rhenium(I) tricarbonyl complexes bearing diimine ligands. This library was evaluated for anticancer activity in three different cancer cell lines, enabling the identification of three lead compounds with cancer cell growth-inhibitory activities of less than 10 μM. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.8b03552DOI Listing
February 2019

MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K-AKT-β-catenin pathways.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Imaging, Binzhou Medical University, Yantai, China.

Membrane-associated RING-CH-1 (MARCH1) is a membrane-anchored E3 ubiquitin ligase that is involved in a variety of cellular processes. MARCH1 was aberrantly expressed as a tumour promoter in ovarian cancer, but the signalling about the molecular mechanism has not yet been fully illuminated. Here, we first determined that MARCH1 was obviously highly expressed in human hepatocellular carcinoma samples and cells. Read More

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http://dx.doi.org/10.1111/jcmm.14235DOI Listing
February 2019

MEG3: an Oncogenic Long Non-coding RNA in Different Cancers.

Pathol Oncol Res 2019 Feb 21. Epub 2019 Feb 21.

Genome Research Chair, College of Science, King Saud University, Riyadh, Saudi Arabia.

Long noncoding RNAs (lncRNAs) have recently considered as central regulators in diverse biological processes and emerged as vital players controlling tumorigenesis. Several lncRNAs can be classified into oncogenes and tumor suppressor genes depending on their function in cancer. A maternally expressed gene 3 (MEG3) gene transcripts a 1. Read More

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http://dx.doi.org/10.1007/s12253-019-00614-3DOI Listing
February 2019

Long-Term Follow-Up after Surgical Management for Atypical Endometriosis: A Series of Nine Cases.

Case Rep Oncol 2019 Jan-Apr;12(1):76-83. Epub 2019 Jan 21.

Department of obstetrics and gynecology, Nara Medical University, Nara, Japan.

Background And Objective: Atypical endometriosis is reported to possess a precancerous potential attributed to premalignant changes characterized by cytological atypia and architecture proliferation. Although the coexistence of atypical endometriosis and neoplasms has been reported, cases of atypical endometriosis transformation to carcinoma are rarely reported. The purpose of this case series was to evaluate the prognosis of atypical endometriosis. Read More

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http://dx.doi.org/10.1159/000496178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381887PMC
January 2019

MicroRNAs in Female Malignancies.

Cancer Inform 2019 13;18:1176935119828746. Epub 2019 Feb 13.

University of Aberdeen, School of Medicine and Dentistry, Aberdeen, UK.

MicroRNAs (miRNAs) are endogenous 22-nucleotide RNAs that can play a fundamental regulatory role in the gene expression of various organisms. Current research suggests that miRNAs can assume pivotal roles in carcinogenesis. In this article, through bioinformatics mining and computational analysis, we determine a single miRNA commonly involved in the development of breast, cervical, endometrial, ovarian, and vulvar cancer, whereas we underline the existence of 7 more miRNAs common in all examined malignancies with the exception of vulvar cancer. Read More

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http://dx.doi.org/10.1177/1176935119828746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376555PMC
February 2019

Higher CXCL16 exodomain is associated with aggressive ovarian cancer and promotes the disease by CXCR6 activation and MMP modulation.

Sci Rep 2019 Feb 21;9(1):2527. Epub 2019 Feb 21.

Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA.

Ovarian cancer (OvCa) is the leading cause of death from gynecological malignancies. Five-year survival rate of OvCa ranges from 30-92%, depending on the spread of disease at diagnosis. Role of chemokines is well appreciated in cancer, including OvCa. Read More

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http://dx.doi.org/10.1038/s41598-019-38766-6DOI Listing
February 2019

[Surgery for advanced stage ovarian cancer: Article drafted from the French Guidelines in oncology entitled "Initial management of patients with epithelial ovarian cancer" developed by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY under the aegis of CNGOF and endorsed by INCa].

Gynecol Obstet Fertil Senol 2019 Feb 18. Epub 2019 Feb 18.

IMRB, U955 Inserm, service de gynécologie obstétrique et médecine de la reproduction, centre hospitalier intercommunal de Créteil, institut Mondor de recherche biomédicale, 94000 Créteil, France. Electronic address:

Debulking surgery is the key step of advanced stage ovarian cancer treatment with chemotherapy. The quality of surgical resection is the main prognosis factor, thus a complete resection must be achieved (grade A) in an expert center (grade B). Surgery for stage IV is possible and has a benefit in case of complete peritoneal resection (LoE3). Read More

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http://dx.doi.org/10.1016/j.gofs.2019.01.003DOI Listing
February 2019

Impact of somatic molecular profiling on clinical trial outcomes in rare epithelial gynecologic cancer patients.

Gynecol Oncol 2019 Feb 18. Epub 2019 Feb 18.

Department of Medicine, Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Objectives: Conducting clinical trials in rare malignancies is challenging due to the limited number of patients and differences in biologic behavior. We investigated the feasibility and clinical utility of using genomic profiling for rare gynecologic malignancies.

Methods: Rare epithelial gynecologic cancer patients were analyzed for somatic variants through an institutional molecular profiling program using the Sequenom MassArray platform or the TruSeq Amplicon Cancer Panel on the MiSeq platform. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.02.005DOI Listing
February 2019

Paclitaxel-Induced Src Activation Is Inhibited by Dasatinib Treatment, Independently of Cancer Stem Cell Properties, in a Mouse Model of Ovarian Cancer.

Cancers (Basel) 2019 Feb 19;11(2). Epub 2019 Feb 19.

Fiona Elsey Cancer Research Institute, Ballarat, VIC 3350, Australia.

Approximately seventy percent of ovarian cancer patients succumb to the disease within the first 5 years of diagnosis, even after successful surgery and effective chemotherapy treatment. A small subset of chemotherapy resistant cancer stem cells (CSCs) cause relapse of ovarian cancers. This study investigated the association between paclitaxel-mediated Src activation (p-Src) and CSC populations in driving ovarian cancer progression. Read More

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http://dx.doi.org/10.3390/cancers11020243DOI Listing
February 2019

The Role of Androgen Receptor Signaling in Ovarian Cancer.

Cells 2019 Feb 19;8(2). Epub 2019 Feb 19.

Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.

Emerging evidence has suggested that androgen receptor signaling plays an important role in ovarian cancer outgrowth. Specifically, androgen receptor activation appears to be associated with increased risks of developing ovarian cancer and inducing tumor progression. However, conflicting findings have also been reported. Read More

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http://dx.doi.org/10.3390/cells8020176DOI Listing
February 2019

Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer.

Int J Mol Sci 2019 Feb 19;20(4). Epub 2019 Feb 19.

Department of Experimental Medicine (DIMES) and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, 16132 Genoa, Italy.

The crosstalk between cancer cells and host cells is a crucial prerequisite for tumor growth and progression. The cells from both the innate and adaptive immune systems enter into a perverse relationship with tumor cells to create a tumor-promoting and immunosuppressive tumor microenvironment (TME). Epithelial ovarian cancer (EOC), the most lethal of all gynecological malignancies, is characterized by a unique TME that paves the way to the formation of metastasis and mediates therapy resistance through the deregulation of immune surveillance. Read More

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http://dx.doi.org/10.3390/ijms20040890DOI Listing
February 2019

Long non-coding RNA RP11-552M11.4 favors tumorigenesis and development of cervical cancer via modulating miR-3941/ATF1 signaling.

Int J Biol Macromol 2019 Feb 18. Epub 2019 Feb 18.

Laboratory for Advanced Interdisciplinary Research, Institutes of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:

As one of the most aggressive malignancies, cervical cancer (CC) which mainly affects females has high risks of relapse and death. Long non-coding RNA (lncRNA) RP11-552M11.4 is verified to promote the progression of ovarian cancer; nevertheless, its role and the probable molecular mechanisms in CC remain unclear until the present study. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.083DOI Listing
February 2019

Lived experiences and support needs of women who developed chemotherapy-induced peripheral neuropathy following treatment for breast and ovarian cancer.

Eur J Cancer Care (Engl) 2019 Feb 20:e13011. Epub 2019 Feb 20.

School of Health Sciences, University of Surrey, Guildford, UK.

Objectives: This study explored lived experiences of women who developed chemotherapy-induced peripheral neuropathy (CIPN) following treatment for breast and ovarian cancer. It also explored cancer survivors' perceptions of information and advice offered by clinicians about CIPN and for managing CIPN.

Methods: The study was advertised through cancer charity websites and social media accounts. Read More

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http://dx.doi.org/10.1111/ecc.13011DOI Listing
February 2019

Effects of human umbilical cord mesenchymal stem cells on co-cultured ovarian carcinoma cells.

Microsc Res Tech 2019 Feb 20. Epub 2019 Feb 20.

Neurobiology Laboratory, Luohe Medical College, Luohe, China.

Ovarian carcinoma is mainly treated by surgery aided by chemotherapy. If supplemented by stem cells treatment, its recurrence rate and mortality rate will be decreased. This is a new therapy. Read More

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http://dx.doi.org/10.1002/jemt.23236DOI Listing
February 2019

Economic modeling of risk-adapted screen-and-treat strategies in women at high risk for breast or ovarian cancer.

Eur J Health Econ 2019 Feb 21. Epub 2019 Feb 21.

Center for Hereditary Breast and Ovarian Cancer, University Hospital Cologne, Kerpener Straße 34, 50931, Cologne, Germany.

Background: The 'German Consortium for Hereditary Breast and Ovarian Cancer' (GC-HBOC) offers women with a family history of breast and ovarian cancer genetic counseling. The aim of this modeling study was to evaluate the cost-effectiveness of genetic testing for BRCA 1/2 in women with a high familial risk followed by different preventive interventions (intensified surveillance, risk-reducing bilateral mastectomy, risk-reducing bilateral salpingo-oophorectomy, or both mastectomy and salpingo-oophorectomy) compared to no genetic test.

Methods: A Markov model with a lifelong time horizon was developed for a cohort of 35-year-old women with a BRCA 1/2 mutation probability of ≥ 10%. Read More

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http://dx.doi.org/10.1007/s10198-019-01038-1DOI Listing
February 2019

Author response to "a response to 'personalised medicine and population health: breast and ovarian cancer'".

Authors:
Steven A Narod

Hum Genet 2019 Feb 21. Epub 2019 Feb 21.

Women's College Research Institute, Women's College Hospital, 76 Grenville Street, M5S 1B2, Toronto, Ontario, Canada.

The author engages in further debate between numerous signatories of a letter who disputes that the author has put forward that the anticipated benefits of a personalised program for cancer prevention and screening are unwarranted. In the event that a cancer screening program is an effective means of mortality reduction, then the best strategy is universality. The benefit of a novel intervention should be evaluated prior to its introduction. Read More

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http://dx.doi.org/10.1007/s00439-019-01981-2DOI Listing
February 2019

Patterns of referral and uptake of BReast CAncer (BRCA) gene testing of eligible women with ovarian cancer in New Zealand.

N Z Med J 2019 Feb 22;132(1490):26-35. Epub 2019 Feb 22.

Senior Lecturer, Department of Obstetrics & Gynaecology, University of Otago, Christchurch & Gynaecological Oncologist, Christchurch Women's Hospital, Christchurch.

Aims: To determine the proportion of eligible patients with high-grade serous carcinoma of the ovary, fallopian tube or peritoneum discussed at gynaecological oncology multidisciplinary meetings (MDMs) in New Zealand and subsequently referred for genetic counselling and BRCA pathogenic variant testing.

Methods: Eligible cases were identified from Auckland, Wellington, Christchurch and Dunedin gynaecologic oncology MDM databases between 1 January 2015 to 31 December 2016. Patients who met the eligibility criteria for genetics referral were identified, and cross-referenced against genetic services databases to ascertain the rates of referrals received, the numbers attending appointments, genetic testing offered and range of results. Read More

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February 2019

Synthesis and evaluation of novel 7H-pyrrolo-[2,3-d]pyrimidine derivatives as potential anticancer agents.

Future Med Chem 2019 Feb 21. Epub 2019 Feb 21.

TMU Biomedical Commercialization Center, Taipei Medical University,  Taipei, Taiwan.

Aim: Bladder cancer is a highly recurrent urologic malignancy with limited treatment approaches. Previously, we reported compound 11 is a FGFR3 inhibitor with significant antibladder cancer activity.

Materials & Methods: In this study, a series of 7H-pyrrolo-[2,3-d]pyrimidine derivatives were synthesized through ring formation and modification of compound 11 for anticancer activity evaluation. Read More

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http://dx.doi.org/10.4155/fmc-2018-0564DOI Listing
February 2019

The use of cisplatin plus doxorubicin or paclitaxel in hyperthermic intraperitoneal chemotherapy (HIPEC) for stage IIIC or IV epithelial ovarian cancer: a comparative study.

Clin Transl Oncol 2019 Feb 20. Epub 2019 Feb 20.

Department of Medical Oncology, University Hospital of Fuenlabrada, C/Camino del Molino 2, 28942, Fuenlabrada, Madrid, Spain.

Purpose: Our main aim is to analyze the survival results in women operated on for advanced ovarian cancer with two different HIPEC regimens (cisplatin plus doxorubicin versus paclitaxel).

Patients And Methods: A prospective cohort of patients with stage IIIC or IV epithelial ovarian cancer operated on with cytoreductive surgery and HIPEC, from October-2008 to February-2016, was retrospectively analyzed. The two drugs used, cisplatin/doxorubicin (Group A) and paclitaxel (Group B), were compared. Read More

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http://dx.doi.org/10.1007/s12094-019-02065-3DOI Listing
February 2019

Oncofertility: insights from IVF specialists-a worldwide web-based survey analysis.

J Assist Reprod Genet 2019 Feb 20. Epub 2019 Feb 20.

The Reproductive Medicine and IVF Unit, Kaplan Medical Center, 76100, Rehovot, Israel.

Purpose: This research sought to understand IVF-physicians' knowledge of, experience with, and attitudes toward fertility preservation for cancer patients.

Methods: A 35-question, self-report survey request was emailed to IVF providers who were registered on the IVF-Worldwide.com network (3826 clinics). Read More

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http://dx.doi.org/10.1007/s10815-019-01419-8DOI Listing
February 2019

Extended abdominopelvic MRI versus CT at the time of adnexal mass characterization for assessing radiologic peritoneal cancer index (PCI) prior to cytoreductive surgery.

Abdom Radiol (NY) 2019 Feb 20. Epub 2019 Feb 20.

Department of Surgical Oncology, Oncology Center Mansoura University, Mansoura, Egypt.

Purpose: To evaluate whether extending the MRI scan to include the abdomen at the time of adnexal mass characterization could replace additional CT for peritoneal cancer index (PCI) assessment.

Methods: After institutional review board approval for this prospective study, 36 consecutive females with ovarian and FT malignancies were included. All patients signed an informed consent. Read More

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http://dx.doi.org/10.1007/s00261-019-01939-yDOI Listing
February 2019

LINC01127 promotes the development of ovarian tumors by regulating the cell cycle.

Am J Transl Res 2019 15;11(1):406-417. Epub 2019 Jan 15.

Department of Gynecology, The First Affiliated Hospital of Nanjing Medical University Nanjing, People's Republic of China.

Background: Ovarian cancer is characterized by the high mortality rate and poor prognosis. Nevertheless, the oncogenesis mechanisms of ovarian cancer remain unclear. In our study, we focused on the potential role of lncRNA LINC01127 in the pathogenesis of ovarian cancer and its underlying mechanism. Read More

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January 2019

Biological functions of circular RNAs and their roles in occurrence of reproduction and gynecological diseases.

Am J Transl Res 2019 15;11(1):1-15. Epub 2019 Jan 15.

Department of Clinical Laboratory, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital Nanjing 210029, Jiangsu, China.

Circular RNAs (circRNAs) are a large class of non coding endogenous RNAs in eukaryotic that are formed through 3'-5' ligation of a single RNA molecule. According to the different sources of the sequences, circRNA can be divided into three types: exon circRNA (ecRNA), intron circRNA (ciRNA), and exon-intron circRNA. Accumulating studies have shown that circRNAs are abundant, diverse, stable, and cell or tissue specific expression, etc. Read More

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January 2019

The lncRNA promotes epithelial ovarian cancer cell proliferation and invasion via the WNT/β-catenin pathway [Retraction].

Authors:

Onco Targets Ther 2019 4;12:1041. Epub 2019 Feb 4.

[This retracts the article on p. 6845 in vol. 11, PMID: 30349317. Read More

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http://dx.doi.org/10.2147/OTT.S203520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366358PMC
February 2019

Genome-wide association study of germline variants and breast cancer-specific mortality.

Authors:
Maria Escala-Garcia Qi Guo Thilo Dörk Sander Canisius Renske Keeman Joe Dennis Jonathan Beesley Julie Lecarpentier Manjeet K Bolla Qin Wang Jean Abraham Irene L Andrulis Hoda Anton-Culver Volker Arndt Paul L Auer Matthias W Beckmann Sabine Behrens Javier Benitez Marina Bermisheva Leslie Bernstein Carl Blomqvist Bram Boeckx Stig E Bojesen Bernardo Bonanni Anne-Lise Børresen-Dale Hiltrud Brauch Hermann Brenner Adam Brentnall Louise Brinton Per Broberg Ian W Brock Sara Y Brucker Barbara Burwinkel Carlos Caldas Trinidad Caldés Daniele Campa Federico Canzian Angel Carracedo Brian D Carter Jose E Castelao Jenny Chang-Claude Stephen J Chanock Georgia Chenevix-Trench Ting-Yuan David Cheng Suet-Feung Chin Christine L Clarke Emilie Cordina-Duverger Fergus J Couch David G Cox Angela Cox Simon S Cross Kamila Czene Mary B Daly Peter Devilee Janet A Dunn Alison M Dunning Lorraine Durcan Miriam Dwek Helena M Earl Arif B Ekici A Heather Eliassen Carolina Ellberg Christoph Engel Mikael Eriksson D Gareth Evans Jonine Figueroa Dieter Flesch-Janys Henrik Flyger Marike Gabrielson Manuela Gago-Dominguez Eva Galle Susan M Gapstur Montserrat García-Closas José A García-Sáenz Mia M Gaudet Angela George Vassilios Georgoulias Graham G Giles Gord Glendon David E Goldgar Anna González-Neira Grethe I Grenaker Alnæs Mervi Grip Pascal Guénel Lothar Haeberle Eric Hahnen Christopher A Haiman Niclas Håkansson Per Hall Ute Hamann Susan Hankinson Elaine F Harkness Patricia A Harrington Steven N Hart Jaana M Hartikainen Alexander Hein Peter Hillemanns Louise Hiller Bernd Holleczek Antoinette Hollestelle Maartje J Hooning Robert N Hoover John L Hopper Anthony Howell Guanmengqian Huang Keith Humphreys David J Hunter Wolfgang Janni Esther M John Michael E Jones Arja Jukkola-Vuorinen Audrey Jung Rudolf Kaaks Maria Kabisch Katarzyna Kaczmarek Michael J Kerin Sofia Khan Elza Khusnutdinova Johanna I Kiiski Cari M Kitahara Julia A Knight Yon-Dschun Ko Linetta B Koppert Veli-Matti Kosma Peter Kraft Vessela N Kristensen Ute Krüger Tabea Kühl Diether Lambrechts Loic Le Marchand Eunjung Lee Flavio Lejbkowicz Lian Li Annika Lindblom Sara Lindström Martha Linet Jolanta Lissowska Wing-Yee Lo Sibylle Loibl Jan Lubiński Michael P Lux Robert J MacInnis Melanie Maierthaler Tom Maishman Enes Makalic Arto Mannermaa Mehdi Manoochehri Siranoush Manoukian Sara Margolin Maria Elena Martinez Dimitrios Mavroudis Catriona McLean Alfons Meindl Pooja Middha Nicola Miller Roger L Milne Fernando Moreno Anna Marie Mulligan Claire Mulot Rami Nassir Susan L Neuhausen William T Newman Sune F Nielsen Børge G Nordestgaard Aaron Norman Håkan Olsson Nick Orr V Shane Pankratz Tjoung-Won Park-Simon Jose I A Perez Clara Pérez-Barrios Paolo Peterlongo Christos Petridis Mila Pinchev Karoliona Prajzendanc Ross Prentice Nadege Presneau Darya Prokofieva Katri Pylkäs Brigitte Rack Paolo Radice Dhanya Ramachandran Gadi Rennert Hedy S Rennert Valerie Rhenius Atocha Romero Rebecca Roylance Emmanouil Saloustros Elinor J Sawyer Daniel F Schmidt Rita K Schmutzler Andreas Schneeweiss Minouk J Schoemaker Fredrick Schumacher Lukas Schwentner Rodney J Scott Christopher Scott Caroline Seynaeve Mitul Shah Jacques Simard Ann Smeets Christof Sohn Melissa C Southey Anthony J Swerdlow Aline Talhouk Rulla M Tamimi William J Tapper Manuel R Teixeira Maria Tengström Mary Beth Terry Kathrin Thöne Rob A E M Tollenaar Ian Tomlinson Diana Torres Thérèse Truong Constance Turman Clare Turnbull Hans-Ulrich Ulmer Michael Untch Celine Vachon Christi J van Asperen Ans M W van den Ouweland Elke M van Veen Camilla Wendt Alice S Whittemore Walter Willett Robert Winqvist Alicja Wolk Xiaohong R Yang Yan Zhang Douglas F Easton Peter A Fasching Heli Nevanlinna Diana M Eccles Paul D P Pharoah Marjanka K Schmidt

Br J Cancer 2019 Feb 21. Epub 2019 Feb 21.

The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam, The Netherlands.

Background: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry.

Methods: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Read More

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http://dx.doi.org/10.1038/s41416-019-0393-xDOI Listing
February 2019

Clinicopathological correlation of ARID1A status with HDAC6 and its related factors in ovarian clear cell carcinoma.

Sci Rep 2019 Feb 20;9(1):2397. Epub 2019 Feb 20.

Department of Pathology, Saitama Medical University International Medical Centre, Saitama, Japan.

Ovarian clear cell carcinoma (OCCC) is associated with a frequent loss in ARID1A function. ARID1A reportedly suppresses histone deacetylase (HDAC)6 in OCCC directly. Here, we evaluated the clinical significance of HDAC6 expression and its related factors in terms of ARID1A status. Read More

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http://dx.doi.org/10.1038/s41598-019-38653-0DOI Listing
February 2019

Effects of CytoReductive surgery plus hyperthermic IntraPEritoneal chemotherapy (HIPEC) versus CytoReductive surgery for ovarian cancer patients: A systematic review and meta-analysis.

Eur J Surg Oncol 2019 Mar 24;45(3):301-309. Epub 2018 Oct 24.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China. Electronic address:

Background: The effects of Hyperthermic IntraPEritoneal Chemotherapy (HIPEC) and CytoReductive Surgery (CRS) for ovarian cancer patients remain controversial.

Methods: A systematic review and meta-analysis was conducted using PubMed, Embase and Web of Science databases to investigate Overall Survival (OS), Disease Free Survival (DFS) and adverse effects between HIPEC and CRS group.

Results: In our overall analysis (13 studies), patients in the HIPEC group exhibited a significantly improved OS (HR = 0. Read More

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http://dx.doi.org/10.1016/j.ejso.2018.10.528DOI Listing

Next-generation sequencing-based genomic profiling analysis reveals novel mutations for clinical diagnosis in Chinese primary epithelial ovarian cancer patients.

J Ovarian Res 2019 Feb 20;12(1):19. Epub 2019 Feb 20.

School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, 1168 Western Chunrong Road, Yuhua Street, Cheng Gong District, Kunming, Yunnan, 650500, People's Republic of China.

Background: Ovarian cancer (OC) is one of the most malignant gynecological tumors, associated with excess death rate (50-60%) in ovarian cancer patients. Particularly, among newly occurred ovarian cancer patients, 70% of clinical cases are diagnosed at the advanced stage, which definitely delay the timely treatment and lead to high mortality rate within 5 years post diagnosis. Therefore, identification of sensitive gene markers, as well as development of reliable genetic diagnosis, are important for the early detection and precise therapy for OC patients. Read More

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http://dx.doi.org/10.1186/s13048-019-0494-4DOI Listing
February 2019

Role of ADAM17 as a regulatory checkpoint of CD16A in NK cells and as a potential target for cancer immunotherapy.

J Leukoc Biol 2019 Feb 20. Epub 2019 Feb 20.

Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, USA.

Human NK cell antitumor activities involve Ab-dependent cell-mediated cytotoxicity (ADCC), which is a key mechanism of action for several clinically successful tumor-targeting therapeutic mAbs. Human NK cells exclusively recognize these Abs by the Fcγ receptor CD16A (FcγRIIIA), one of their most potent activating receptors. Unlike other activating receptors on NK cells, CD16A undergoes a rapid down-regulation in expression by a proteolytic process following NK cell activation with various stimuli. Read More

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http://dx.doi.org/10.1002/JLB.2MR1218-501RDOI Listing
February 2019

NK007 helps in mitigating paclitaxel resistance through p38MAPK activation and HK2 degradation in ovarian cancer.

J Cell Physiol 2019 Feb 20. Epub 2019 Feb 20.

The First Affiliated Hospital, Biomedical Translational Research Institute and School of Pharmacy, Jinan University, Guangzhou, China.

Ovarian cancer resistance to available medicines is a huge challenge in dire need of a solution, which makes its recurrence and mortality rate further exacerbated. A promising approach to overcome chemoresistance is drug screening from natural products. Here, we report that NK007, a (±)-tylophorine malate isolated from the Asclepiadaceae family, selectively inhibited the proliferation of A2780 and A2780 (Taxol) cells and migration of paclitaxel-sensitive and -resistant ovarian cancer cells. Read More

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http://dx.doi.org/10.1002/jcp.28278DOI Listing
February 2019

The Biospecimen Preanalytical Variables Program: A Multiassay Comparison of Effects of Delay to Fixation and Fixation Duration on Nucleic Acid Quality.

Arch Pathol Lab Med 2019 Feb 20. Epub 2019 Feb 20.

From Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland (Drs Carithers, Guan, Odeh, Sachs, Branton, and Moore);Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland (Drs Agarwal, Barcus, Lih, Williams, Sobin, Roche, and Mr Soria);Preferred Solutions Group, Preferred Scientific Group, Washington, District of Columbia (Dr Engel);Kelly Government Solutions, Kelly Services, Rockville, Maryland (Dr Greytak and Mr Fombonne);the Department of Pathology, University of New Mexico, Albuquerque (Dr Bocklage);the Department of Pathology and Laboratory Medicine, Boston Medical Center, Boston, Massachusetts (Dr Andry and Ms Duffy);the Department of Pathology and Laboratory Medicine, Emory University, Winship Cancer Institute, Atlanta, Georgia (Dr Sica);the Department of Pathology, University of Pittsburg, Pittsburgh, Pennsylvania (Dr Dhir);and Van Andel Research Institute, Pathology and Biorepository Core, VARI Core Technologies and Services, Grand Rapids, Michigan (Dr Jewell).

Context.—: Despite widespread use of formalin-fixed, paraffin-embedded (FFPE) tissue in clinical and research settings, potential effects of variable tissue processing remain largely unknown.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2018-0172-OADOI Listing
February 2019

Frozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls.

Authors:
Natalia Buza

Arch Pathol Lab Med 2019 Jan;143(1):47-64

From the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

Context.—: Epithelial tumors of the ovary are one of the most frequently encountered gynecologic specimens in the frozen section laboratory. The preoperative diagnostic workup of an ovarian mass is typically limited to imaging studies and serum markers, both of which suffer from low sensitivity and specificity. Read More

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http://dx.doi.org/10.5858/arpa.2018-0289-RADOI Listing
January 2019

Novel 2,4-disubstituted quinazolines as cytotoxic agents and JAK2 inhibitors: Synthesis, in vitro evaluation and molecular dynamics studies.

Comput Biol Chem 2019 Jan 21;79:110-118. Epub 2019 Jan 21.

Centre for Molecular Cancer Research (CMCR), Vishnu Institute of Pharmaceutical and Educational Research, Narsapur, India. Electronic address:

Recent studies reported the involvement of JAK2/STAT3 pathway in various solid tumours including breast, ovarian, prostate and lung cancers. Clinical literature also reported the lowered burden in breast and ovarian cancers by targeting JAK2 pathway. In this study, a series of novel 2,4-disubstituted quinazolines (2a-2 j and 3a-3 j) were synthesized and were evaluated for their cytotoxicity against human breast cancer (MDA-MB-231) and ovarian cancer (SK-O-V3) cell lines using MTT assay. Read More

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http://dx.doi.org/10.1016/j.compbiolchem.2019.01.008DOI Listing
January 2019

Bioactivity-Guided Isolation of Totarane-Derived Diterpenes from Podocarpus neriifolius and Structure Revision of 3-Deoxy-2α-hydroxynagilactone E.

Nat Prod Bioprospect 2019 Feb 19. Epub 2019 Feb 19.

Division of Medicinal Chemistry and Pharmacognosy, The Ohio State University, College of Pharmacy, Columbus, OH, USA.

Bioactivity-guided phytochemical investigation of Podocarpus neriifolius D. Don. (Podocarpaceae) has led to the isolation of one new (2) and three known (1, 3, and 4) B-type podolactones, along with three totarane-type diterpenes (5-7). Read More

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http://dx.doi.org/10.1007/s13659-019-0198-xDOI Listing
February 2019

Know your limits: RPA availability and chemoresistance in ovarian cancer.

Oncotarget 2019 Jan 25;10(8):800-802. Epub 2019 Jan 25.

Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, Canada; Programme de Biologie Moléculaire, Université de Montréal, Montréal, Canada; Département de Médecine, Université de Montréal, Montréal, Canada.

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http://dx.doi.org/10.18632/oncotarget.26607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368229PMC
January 2019

Novel triazole analogs of apigenin-7-methyl ether exhibit potent antitumor activity against ovarian carcinoma cells via the induction of mitochondrial-mediated apoptosis.

Exp Ther Med 2019 Mar 28;17(3):1670-1676. Epub 2018 Dec 28.

Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China.

Ovarian cancer is one of the main causes of cancer-associated mortality across the world. Currently, ovarian cancer is mainly treated with chemotherapy. However, ovarian cancer is detected at advanced stages and chemotherapy has numerous side effects. Read More

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http://dx.doi.org/10.3892/etm.2018.7138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364180PMC

Single gold-bridged nanoprobes for identification of single point DNA mutations.

Nat Commun 2019 Feb 19;10(1):836. Epub 2019 Feb 19.

Department of Chemical & Biological Engineering, Korea University, Seoul, 136713, Republic of Korea.

Consensus ranking of protein affinity to identify point mutations has not been established. Therefore, analytical techniques that can detect subtle variations without interfering with native biomolecular interactions are required. Here we report a rapid method to identify point mutations by a single nanoparticle sensing system. Read More

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http://dx.doi.org/10.1038/s41467-019-08769-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381086PMC
February 2019

Exploring the added value of hospital-registry data for showing local service outcomes: cancers of the ovary, fallopian tube and peritoneum.

BMJ Open 2019 Feb 19;9(2):e024036. Epub 2019 Feb 19.

Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Objectives: To explore the added value of hospital-registry data on invasive epithelial ovarian, tubal and peritoneal cancers.

Design: Historic cohort analyses.

Methods: Unadjusted and adjusted regression. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02403
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http://dx.doi.org/10.1136/bmjopen-2018-024036DOI Listing
February 2019
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Organic Anion Transporting Polypeptides: Emerging Roles in Cancer Pharmacology.

Mol Pharmacol 2019 Feb 19. Epub 2019 Feb 19.

Vanderbilt University Medical Center

The organic anion transporting polypeptides (OATPs) are a superfamily of drug transporters involved in the uptake and disposition of a wide array of structurally divergent endogenous and exogenous substrates, including steroid hormones, bile acids, and commonly used drugs, such as anti-infectives, anti-hypertensives, and cholesterol lowering agents. In the past decade, OATPs, primarily OATP1A2, OATP1B1, and OATP1B3, have emerged as potential mediators of chemotherapy disposition, including drugs such as methotrexate, doxorubicin, paclitaxel, docetaxel, irinotecan and its important metabolite SN-38, and certain tyrosine kinase inhibitors. Furthermore, OATP family members are polymorphic and numerous studies have shown OATP variants to have differential uptake, disposition, and/or pharmacokinetics of numerous drug substrates with important implications for interindividual differences in efficacy and toxicity. Read More

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http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.118
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http://dx.doi.org/10.1124/mol.118.114314DOI Listing
February 2019
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Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities.

Proc Natl Acad Sci U S A 2019 Feb 19. Epub 2019 Feb 19.

Department of Cancer Biology and Genetics, Ohio State University, Columbus, OH 43210;

Endometrioid endometrial carcinomas (EECs) carry multiple driver mutations even when they are low grade. However, the biological significance of these concurrent mutations is unknown. We explored the interactions among three signature EEC mutations: loss-of-function (LOF) mutations in , gain-of-function (GOF) mutations of phosphoinositide 3-kinase (PI3K), and exon 3 mutations, utilizing in vivo mutagenesis of the mouse uterine epithelium. Read More

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http://dx.doi.org/10.1073/pnas.1814506116DOI Listing
February 2019

Laparoscopic unilateral oophorectomy for ovarian tissue cryopreservation in children.

J Pediatr Surg 2019 Mar 9;54(3):543-549. Epub 2018 Jun 9.

Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Pediatric Surgery, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.

Background/purpose: Many survivors of childhood cancer will experience premature gonadal insufficiency or infertility as a consequence of their medical treatments. Ovarian tissue cryopreservation (OTC) remains an experimental means of fertility preservation with few reports focused on the surgical technique and postoperative outcomes for OTC in children.

Methods: This is a single institution, retrospective review of OTC cases from January 2011 to December 2017. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383797PMC

Androgen replacement therapy in women.

Expert Rev Endocrinol Metab 2012 Sep;7(5):515-529

a 1Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT, UK.

Female androgens are derived from either the adrenal and peripheral conversion of the adrenal sex steroid precursor, dehydroepiandrosterone, or from direct ovarian production. Adrenal insufficiency or bilateral oophorectomy (surgical menopause) result in severe androgen deficiency, which can be clinically associated with impaired libido, drive and energy. Physiological menopause does not necessarily lead to androgen deficiency. Read More

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http://dx.doi.org/10.1586/eem.12.45DOI Listing
September 2012

Insulin sensitizers for women with polycystic ovarian syndrome.

Expert Rev Endocrinol Metab 2009 Mar;4(2):183-192

b Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, 606 24th Avenue South, Suite 402, Minneapolis, MN 55454, USA.

Polycystic ovarian syndrome (PCOS) is the most frequent endocrine disorder and most common cause of anovulation in women of reproductive age. It is a heterogeneous disorder, characterized by excess androgen, ovulatory dysfunction and/or polycystic ovaries. The syndrome is known for its association with several reproductive problems, including infertility and obstetric adverse effects. Read More

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http://dx.doi.org/10.1586/17446651.4.2.183DOI Listing

Therapeutic Approaches of Resveratrol on Endometriosis via Anti-Inflammatory and Anti-Angiogenic Pathways.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Department of Medical and Surgical Specialties, Faculty of Medicine, Transilvania University of Brasov, 500019 Brasov, Romania.

Endometriosis represents a severe gynecological pathology, defined by implantation of endometrial glands and stroma outside the uterine cavity. This pathology affects almost 15% of women during reproductive age and has a wide range of consequences. In affected women, infertility has a 30% rate of prevalence and endometriosis implants increase the risk of ovarian cancer. Read More

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http://dx.doi.org/10.3390/molecules24040667DOI Listing
February 2019

-Vanillin Derived Schiff Bases and Their Organotin(IV) Compounds: Synthesis, Structural Characterisation, In-Silico Studies and Cytotoxicity.

Int J Mol Sci 2019 Feb 15;20(4). Epub 2019 Feb 15.

Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia.

Six new organotin(IV) compounds of Schiff bases derived from -R-dithiocarbazate [R = benzyl (B), 2- or 4-methylbenzyl (2M and 4M, respectively)] condensed with 2-hydroxy-3-methoxybenzaldehyde (oVa) were synthesised and characterised by elemental analysis, various spectroscopic techniques including infrared, UV-vis, multinuclear (¹H, C, Sn) NMR and mass spectrometry, and single crystal X-ray diffraction. The organotin(IV) compounds were synthesised from the reaction of Ph₂SnCl₂ or Me₂SnCl₂ with the Schiff bases (S2MoVaH/S4MoVaH/SBoVaH) to form a total of six new organotin(IV) compounds that had a general formula of [R₂Sn(L)] (where L = Schiff base; R = Ph or Me). The molecular geometries of Me₂Sn(S2MoVa), Me₂Sn(S4MoVa) and Me₂Sn(SBoVa) were established by X-ray crystallography and verified using density functional theory calculations. Read More

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http://dx.doi.org/10.3390/ijms20040854DOI Listing
February 2019

Resveratrol alleviates chemotherapy-induced oogonial stem cell apoptosis and ovarian aging in mice.

Aging (Albany NY) 2019 Feb 14;11(3):1030-1044. Epub 2019 Feb 14.

Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

Chemotherapy-induced ovarian aging not only increases the risk for early menopause-related complications but also results in infertility in young female cancer survivors. Oogonial stem cells have the ability to generate new oocytes and thus provide new opportunities for treating ovarian aging and female infertility. Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural phenol derived from plants, that has been shown to have positive effects on longevity and redox flow in lipid metabolism and a preventive function against certain tumors. Read More

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http://www.aging-us.com/article/101808/text
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http://dx.doi.org/10.18632/aging.101808DOI Listing
February 2019
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Macrophage ERα promoted invasion of endometrial cancer cell by mTOR/KIF5B -mediated epithelial to mesenchymal transition.

Immunol Cell Biol 2019 Feb 18. Epub 2019 Feb 18.

Institute of Basic Medical Sciences and Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Tumor associated macrophages (TAMs) exert tumor-promoting effects. There have been reports that Estrogen receptors (ERs) are expressed on the infiltrating macrophages of endometriosis, ovarian cancer and lung cancer. However, the role of ERs in macrophages is not well characterized. Read More

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http://dx.doi.org/10.1111/imcb.12245DOI Listing
February 2019

PBK, targeted by EVI1, promotes metastasis and confers cisplatin resistance through inducing autophagy in high-grade serous ovarian carcinoma.

Cell Death Dis 2019 Feb 18;10(3):166. Epub 2019 Feb 18.

Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 250012, Jinan, China.

High-grade serous ovarian carcinoma (HGSOC) is the most lethal type of gynecologic malignancy. Chemoresistance is the main reason for the poor prognosis of HGSOC. PDZ-binding kinase (PBK) promotes the malignant progression of various carcinomas. Read More

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http://www.nature.com/articles/s41419-019-1415-6
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http://dx.doi.org/10.1038/s41419-019-1415-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379381PMC
February 2019
6 Reads