Search Our Scientific Publications & Authors

Epilepsy Behav 2019 Feb 16;93:22-28. Epub 2019 Feb 16.

Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children Hospital, Rome, Italy. Electronic address:

Objective: The objective of the study was to evaluate clinical characteristics and outcome of hemispherotomy in children and adolescents with hemispheric refractory epilepsy in an Italian cohort of patients.

Methods: We retrospectively evaluated the clinical course and outcome of 92 patients with refractory epilepsy who underwent hemispherotomy in three Italian epilepsy centers between 2006 and 2016. Three different approaches for hemispherotomy were used: parasagittal, modified parasagittal, and lateral. Read More

Epilepsy Behav 2019 Feb 16;93:12-15. Epub 2019 Feb 16.

Department of Psychiatry and Medical Psychology, Faculdade de Medicina de São José do Rio Preto (FAMERP), Brazil. Electronic address:

Objective: The objective of this study was to verify if the presence of psychogenic nonepileptic seizures (PNES) could be a risk factor precluding corticoamygdalohippocampectomy (CAH) in patients with refractory temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS) (TLE-MTS).

Methods: This retrospective cohort study analyzed medical data of patients with refractory TLE-MTS accompanied in a Brazilian epilepsy surgery center. Presurgical psychiatric evaluations were performed using the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria. Read More

Clin Neurophysiol 2019 Jan 31;130(4):491-504. Epub 2019 Jan 31.

Laboratory of Children's Brain Dynamics, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Fetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Objective: To evaluate the accuracy and clinical utility of conventional 21-channel EEG (conv-EEG), 72-channel high-density EEG (HD-EEG) and 306-channel MEG in localizing interictal epileptiform discharges (IEDs).

Methods: Twenty-four children who underwent epilepsy surgery were studied. IEDs on conv-EEG, HD-EEG, MEG and intracranial EEG (iEEG) were localized using equivalent current dipoles and dynamical statistical parametric mapping (dSPM). Read More

World Neurosurg 2019 Feb 11. Epub 2019 Feb 11.

Glioma Surgery Division, Neurological Surgery Department of Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address:

Objective: To evaluate the risk factors of tumor related epilepsy (TRE) and the relationship between TRE and functional/survival outcomes in high-grade glioma (HGG) patients.

Method: The clinical data of 587 patients with HGG were retrospectively analyzed. Chi-square test and logistic multiple regression analysis were used to analyze factors associated with TRE. Read More

Orv Hetil 2019 Feb;160(7):270-278

Neurológiai Klinika, Pécsi Tudományegyetem, Általános Orvostudományi Kar Pécs, Rét u. 2., 7623.

Introduction: Epilepsy as a chronic, severe neurologic disease significantly influences the quality of life of the epileptic patients. In candidates well selected for surgery, the seizure freedom is realistically achievable, and the quality of life can be further improved with complex individual rehabilitation.

Aim: We aimed to evaluate the postoperative outcome of patients who underwent epilepsy surgery between 2005 and 2016 at the Epilepsy Center at Pécs. Read More

Epilepsia 2019 Feb 11. Epub 2019 Feb 11.

Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.

Objective: To assess the ability of functional MRI (fMRI) to predict postoperative language decline compared to direct cortical stimulation (DCS) in epilepsy surgery patients.

Methods: In this prospective case series, 17 patients with drug-resistant epilepsy had intracranial monitoring and resection from 2012 to 2016 with 1-year follow-up. All patients completed preoperative language fMRI, mapping with DCS of subdural electrodes, pre- and postoperative neuropsychological testing for language function, and resection. Read More

Epilepsy Behav 2019 Feb 6;92:311-326. Epub 2019 Feb 6.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK; Chalfont Centre for Epilepsy, Chalfont St Peter SL9 0RJ, UK; Stichting Epilepsie Instellingen Nederland (SEIN), Achterweg 5, 2103 SW Heemstede, Netherlands. Electronic address:

Background: Epilepsy surgery is an important treatment option for people with drug-resistant epilepsy. Surgical procedures for epilepsy are underutilized worldwide, but it is far worse in low- and middle-income countries (LMIC), and it is less clear as to what extent people with drug-resistant epilepsy receive such treatment at all. Here, we review the existing evidence for the availability and outcome of epilepsy surgery in LMIC and discuss some challenges and priority. Read More

Epilepsy Behav 2019 Feb 3;92:245-252. Epub 2019 Feb 3.

Melbourne School of Psychological Sciences, The University of Melbourne, Victoria 3010, Australia; Comprehensive Epilepsy Program, Melbourne Brain Centre, 245 Burgundy Street, Austin Health, Heidelberg, Melbourne, Victoria 3084, Australia. Electronic address:

Drug-resistant pediatric epilepsy involves unpredictable seizures and long-term medical management. Both factors can alter a child's psychosocial development and the dynamics of the family, to the detriment of patient and family wellbeing. While drug-resistant pediatric epilepsy can be successfully treated by neurosurgery in some cases, the outlook for psychosocial and family functioning after surgery remains unclear. Read More

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(6):30-37

Burdenko Neurosurgical Institute, Moscow, Russia.

Arteriovenous malformations (AVMs) are some of the most frequent congenital abnormalities of the cerebral vascular system and usually occur at a young age. Given the fact that AVMs can manifest, in addition to hemorrhages, as symptomatic epilepsy (17-40%) that occurs more often at a young age and may lead to significant disability, investigation of this pathology remains topical. Particular attention has recently been paid to the management of AVM patients without clinical signs of hemorrhage at the time of pathology diagnosis. Read More

J Neurosurg Pediatr 2019 Feb 1:1-10. Epub 2019 Feb 1.

Departments of1Functional Neurosurgery and.

OBJECTIVEThe aim of this study was to evaluate the electro-clinical features, etiology, treatment, and postsurgical seizure outcomes in patients with intractable epileptic spasms (ESs).METHODSThe authors retrospectively studied the medical records of all patients who had presented with medically intractable ESs and had undergone surgery in the period between October 2009 and August 2015. The interictal electroencephalography (EEG) pattern, MRI studies, magnetoencephalography findings, and postsurgical seizure outcomes were compared. Read More

Seizure 2019 Jan 25. Epub 2019 Jan 25.

Department of Neurosurgery, Neurology & Neurosurgery Hospital Pierre Wertheimer, Hospices Civils de Lyon, France; University of Lyon, Faculty of medicine Claude Bernard, Lyon, France; NEUROPAIN team, Lyon Neuroscience Research Center, INSERM U1028, CNRS, 5292, Lyon, France.

Stereoelectroencephalography-guided radiofrequency-thermocoagulation (SEEG-guided RF-TC) consists of coupling SEEG investigation with RF-TC stereotactic lesioning directly through the recording electrodes. In this systematic review the surgical technique, indications, and outcomes are described. Maximum accuracy is reached when a frame-based procedure with a robotic assistance and a per-operative vascular X-ray imaging are performed. Read More

Sci Rep 2019 Jan 31;9(1):1086. Epub 2019 Jan 31.

Division of Neurosurgery, Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, 85724, USA.

Among patients with intractable epilepsy, the most commonly performed surgical procedure is craniotomy for amygdalohippocampectomy (AH). Stereotactic laser amygdalohippocampotomy (SLAH) has also been recently employed as a minimally invasive treatment for intractable temporal lobe epilepsy (TLE). Among patients treated with AH and SLAH approximately 65% and 54% of patients become seizure-free, respectively. Read More

J Neurol 2019 Jan 30. Epub 2019 Jan 30.

Department of Neurosurgery, University Hospital of Munich, Ludwig-Maximilians-University, Marchioninistr. 15, 81377, Munich, Germany.

Background: Refined localization of the epileptogenic zone (EZ) in patients with pharmacoresistant focal epilepsy proceeding to resective surgery might improve postoperative outcome. We here report seizure outcome after stereo EEG (sEEG) evaluation with individually planned stereotactically implanted depth electrodes and subsequent tailored resection.

Methods: A cohort of consecutive patients with pharmacoresistant focal epilepsy, evaluated with a non-invasive evaluation protocol and invasive monitoring with personalized, stereotactically implanted depth electrodes for sEEG was analyzed. Read More

Childs Nerv Syst 2019 Jan 30. Epub 2019 Jan 30.

Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.

Objective: To determine whether preoperative non-lateralizing scalp electroencephalography (EEG) influences seizure outcome following peri-insular hemispherotomy (PIH) in pediatric hemispheric epilepsy.

Methods: Retrospective data was collected on all 45 pediatric patients who underwent PIH between 2005 and 2016. All underwent a basic pre-surgical evaluation consisting of detailed history and examination, neuropsychological assessment, MRI, and EEG. Read More

J Inherit Metab Dis 2019 Jan 28. Epub 2019 Jan 28.

Division of Inborn Metabolic Diseases, Department of Paediatrics, University Hospital, Padua, Italy.

Newborn screening for phenylketonuria and early introduction of dietary therapy has been remarkably successful in preventing the severe neurological features of phenylketonuria, including mental retardation and epilepsy. However, concerns remain that long-term outcome is still suboptimal, particularly in adult patients who are no longer on strict phenylalanine-restricted diets. With our systematic literature review we aimed to describe the neurological phenotype of adults with early-treated phenylketonuria (ETPKU). Read More

Clin Neurol Neurosurg 2019 Mar 17;178:7-12. Epub 2019 Jan 17.

Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey. Electronic address:

Objective: To see what happens on PET hypometabolism on the temporal lobe contralateral to the side of surgery in patients with bitemporal hypometabolism (BTH).

Patients And Methods: This retrospective study with prospectively defined data evaluated the pre- and post-surgical PET hypometabolism on the contralateral temporal lobe after resection of ipsilateral temporal lobe in 10 patients with BTH operated between January, 2010 and May, 2018. On PET we compared standard uptake values (SUV) and relative metabolic activities as compared to normal subjects by means of Z-scores of hypometabolism of unresected temporal lobes before and after surgery. Read More

Neuroimage Clin 2019 Jan 9:101657. Epub 2019 Jan 9.

Laboratory for Epilepsy Research, KU Leuven, Herestraat 49, Box 7003, 3000 Leuven, Belgium; Department of Neurology, UZ Leuven, Belgium. Electronic address:

Background And Objective: Transcranial magnetic stimulation (TMS) is a useful technique to help localize motor function prior to neurosurgical procedures. Adequate modelling of the effect of TMS on the brain is a prerequisite to obtain reliable data.

Methods: Twelve patients were included with perirolandic tumors to undergo TMS-based motor mapping. Read More

Epilepsy Behav 2019 Jan 16;92:145-153. Epub 2019 Jan 16.

National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan.

Purpose: Cavernous malformation (CM) in the temporal neocortex causes intractable epilepsy. Whether to resect additional mesial temporal structures in addition to the lesionectomy is a still controversial issue. To clarify the need for the procedure, we retrospectively analyzed pre- and postoperative clinical data of patients with surgically removed CM. Read More

Stereotact Funct Neurosurg 2018 16;96(6):406-411. Epub 2019 Jan 16.

Department of Neurosurgery, University of Louisville School of Medicine, Louisville, Kentucky,

Corpus callosotomy is a viable treatment for patients with refractory generalized or multifocal epilepsy, particularly those who have drop attacks. Laser interstitial thermal therapy (LITT) is a minimally invasive surgical option for various intracranial lesions. In this report, we present a 2-trajectory thermal ablation using the NeuroBlate® system (Monteris Medical, MN, USA) for an anterior two-thirds callosotomy in a patient with refractory epilepsy and frequent drop attacks. Read More

QJM 2019 Jan 10. Epub 2019 Jan 10.

Department of Anesthesiology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

Background: The association between Parkinson's disease (PD) and stroke remains completely understood.

Aim: We aimed to investigate stroke risk and post-stroke outcomes in patients with PD.

Design: The retrospective cohort study included 1303 patients aged ≥ 40 years with new-diagnosed PD and 5212 non-PD adults were selected by frequency matching with age and sex in 2000-2005. Read More

J Clin Neurol 2019 Jan;15(1):84-89

Department of Pediatrics, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.

Background And Purpose: This study investigated the seizure recurrence rate and potential predictors of seizure recurrence following antiepileptic drug (AED) withdrawal after resective epilepsy surgery in children with focal cortical dysplasia (FCD).

Methods: We retrospectively analyzed the records of 70 children and adolescents with FCD types I, II, and IIIa who underwent resective epilepsy surgery between 2004 and 2015 and were followed for at least 2 years after surgery.

Results: We attempted AED withdrawal in 40 patients. Read More

Ann Neurol 2019 Feb 17;85(2):241-250. Epub 2019 Jan 17.

Departments of Medicine and Neurology, Melbourne Brain Centre, University of Melbourne, Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Objective: We investigated the relationship between the interictal metabolic patterns, the extent of resection of F-fluorodeoxyglucose positron emission tomography ( FDG-PET) hypometabolism, and seizure outcomes in patients with unilateral drug-resistant mesial temporal lobe epilepsy (MTLE) following anterior temporal lobe (TL) resection.

Methods: Eighty-two patients with hippocampal sclerosis or normal magnetic resonance imaging (MRI) findings, concordant FDG-PET hypometabolism, and at least 2 years of postoperative follow-up were included in this 2-center study. The hypometabolic regions in each patient were identified with reference to 20 healthy controls (p < 0. Read More

Seizure 2018 Dec 18. Epub 2018 Dec 18.

Department of Epileptology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.

Laser interstitial thermotherapy (LiTT) is a novel stereotactic approach to the surgical treatment of severe drug-resistant focal epilepsies. This review extends our recent general review on this topic (Hoppe et al. Laser interstitial thermotherapy [LiTT] in epilepsy surgery. Read More

Epilepsia 2019 Jan 26;60(1):107-120. Epub 2018 Dec 26.

Epilepsy Center, Cleveland Clinic Foundation, Cleveland, Ohio.

Objective: We aimed to determine the rates and predictors of resection and seizure freedom after bilateral stereo-electroencephalography (SEEG) implantation.

Methods: We reviewed 184 patients who underwent bilateral SEEG implantation (2009-2015). Noninvasive and invasive evaluation findings were collected. Read More

World Neurosurg 2018 Dec 19. Epub 2018 Dec 19.

Brain Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea. Electronic address:

Background: Most surgical treatments for medically intractable temporal lobe epilepsy are helpful. When a patient has persistent symptoms after surgery, there are no tests that accurately predict whether a patient will have remnant epileptic foci. The aim of this study was to evaluate the usefulness of magnetoencephalography (MEG) as a prognostic tool in patients with temporal lobe epilepsy. Read More

Epilepsia 2019 Feb 21;60(2):233-245. Epub 2018 Dec 21.

Bethel Epilepsy Center, Mara Hospital, Bielefeld, Germany.

Objective: Surgical volumes at large epilepsy centers are decreasing. Pediatric cohorts, however, show a trend toward more resections and superior outcome. Differences in pediatric and adult epilepsy surgery were investigated in our cohort. Read More

Med Sci Monit 2018 Dec 21;24:9292-9299. Epub 2018 Dec 21.

Department of Traditional Chinese Medicine, Tianjin 4th Center Hospital, Tianjin, China (mainland).

BACKGROUND Drug-resistant epilepsy is a common neurological disease in adults and children. This study aimed to undertake a systematic review of the literature with meta-analysis of the data from published studies to assess the effectiveness of magnetic resonance imaging (MRI)-guided laser interstitial thermal therapy (LITT) in treatment-resistant epilepsy. MATERIAL AND METHODS The study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Read More

Seizure 2019 Jan 26;64:50-53. Epub 2018 Nov 26.

Clinique d'Investigation Neuro-Cardiaque (CINC), CHU Sainte-Justine, Montreal, Canada.

Purpose: Children with complex congenital heart disease (CHD) experience high incidence of perioperative seizures. Population-based studies also report high epilepsy co-morbidity in CHD. Given the increasing survival of patients with CHD and the interference of seizures and epilepsy with the long-term outcomes, characterizing them in this population is of high relevance. Read More

Cortex 2018 Nov 17;113:1-14. Epub 2018 Nov 17.

Neuroscience and Aphasia Research Unit, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, UK; MRC Cognition and Brain Sciences Unit, University of Cambridge, UK. Electronic address:

In neurosurgery there are several situations that require transgression of the temporal cortex. For example, a subset of patients with temporal lobe epilepsy require surgical resection (most typically, en-bloc anterior temporal lobectomy). This procedure is the gold standard to alleviate seizures but is associated with chronic cognitive deficits. Read More

J Neurosurg Pediatr 2018 Nov 1:1-11. Epub 2018 Nov 1.

1Division of Neurosurgery, Department of Surgery, University of Toronto.

OBJECTIVEDrug-resistant epilepsy (DRE) presents a therapeutic challenge in children, necessitating the consideration of multiple treatment options. Although deep brain stimulation (DBS) has been studied in adults with DRE, little evidence is available to guide clinicians regarding the application of this potentially valuable tool in children. Here, the authors present the first systematic review aimed at understanding the safety and efficacy of DBS for DRE in pediatric populations, emphasizing patient selection, device placement and programming, and seizure outcomes. Read More

Clin Neurophysiol 2019 Jan 26;130(1):128-137. Epub 2018 Nov 26.

Epilepsy Centre, Medical Center - University of Freiburg, Germany. Electronic address:

Objective: High frequency oscillations (HFO) between 80-500 Hz are markers of epileptic areas in intracranial and maybe also scalp EEG. We investigate simultaneous recordings of scalp and intracranial EEG and hypothesize that scalp HFOs provide important additional clinical information in the presurgical setting.

Methods: Spikes and HFOs were visually identified in all intracranial scalp EEG channels. Read More

Clin Neurophysiol 2019 Jan 26;130(1):122-127. Epub 2018 Nov 26.

Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.

Objective: To evaluate EEG abnormalities, particularly development of temporal intermittent rhythmic delta activity (TIRDA) after laser interstitial thermal therapy (LITT) and assess the role of further surgery after LITT.

Methods: We retrospectively identified consecutive cases of LITT for the prevalence of post-operative TIRDA. We assessed baseline demographics, clinical variables including age of seizure onset, age at surgery, pre-operative and post-operative EEG changes. Read More

Epilepsy Behav 2019 Jan 3;90:93-98. Epub 2018 Dec 3.

IRCCS "NEUROMED", Pozzilli, IS, Italy; Department of Neurology and Psychiatry, "Sapienza" University of Rome, Italy.

Purpose: The purpose of this study was to report long-term seizure outcome in patients who underwent frontal lobe epilepsy (FLE) surgery.

Method: This retrospective study included 44 consecutive subjects who underwent resective surgery for intractable FLE at IRCCS NEUROMED (period 2001-2014), followed up for at least 2 years (mean: 8.7 years). Read More

Atherosclerosis 2019 Jan 23;280:147-154. Epub 2018 Nov 23.

Department of Anesthesiology, Shuan Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Anesthesiology, Taipei Medical University Hospital, Taipei, Taiwan; Health Policy Research Center, Taipei Medical University Hospital, Taipei, Taiwan; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan. Electronic address:

Background And Aims: The risk of stroke in epileptic patients and the impact of epilepsy history on stroke patients' outcome have not been studied completely. Our purpose is to evaluate whether patients with epilepsy have increased risk of stroke or post-stroke mortality.

Methods: In Study I, we conducted a retrospective cohort study of 6746 patients with newly diagnosed epilepsy and 26,984 persons without epilepsy between 2000 and 2008, in the database of National Health Insurance in Taiwan. Read More

Neurotherapeutics 2019 Jan;16(1):182-191

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, 33 Queen Square, London, WC1E 6BT, UK.

Laser interstitial thermal therapy (LITT) is an alternative to open surgery for drug-resistant focal mesial temporal lobe epilepsy (MTLE). Studies suggest maximal ablation of the mesial hippocampal head and amygdalohippocampal complex (AHC) improves seizure freedom rates while better neuropsychological outcomes are associated with sparing of the parahippocampal gyrus (PHG). Optimal trajectories avoid sulci and CSF cavities and maximize distance from vasculature. Read More

JAMA Neurol 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut.

Importance: Seizures recur in as many as half of patients who undergo surgery for drug-resistant temporal lobe epilepsy (TLE). Understanding why TLE is resistant to surgery in some patients may reveal insights into epileptogenic networks and direct new therapies to improve outcomes.

Objective: To characterize features of surgically refractory TLE. Read More

Neurol India 2018 Nov-Dec;66(6):1655-1666

Department of Neurology, National Institute of Mental Health and Neuro-Sciences, Bangalore, Karnataka, India.

Aim: Surgery for drug resistant epilepsy (DRE) with focal cortical dysplasia (FCD) often requires multiple non-invasive as well as invasive pre-surgical evaluations and innovative surgical strategies. There is limited data regarding surgical management of people with FCD as the underlying substrate for DRE among the low and middle-income countries (LAMIC) including India.

Methodology: The presurgical evaluation, surgical strategy and outcome of 52 people who underwent resective surgery for DRE with FCD between January 2008 and December 2016 were analyzed. Read More

Rev Prat 2017 12;67(10):1111-1115

Service de neurochirurgie, centre hospitalier Sainte-Anne, université Paris-Descartes Paris, France.

Epilepsy surgery. Epilepsy surgery is indicated for adults or children with partial, drug-resistant and disabling epilepsy. It has developed over the last few decades through better identification of candidates, advances in imaging and surgical techniques. Read More

Epilepsia 2018 Dec 22;59(12):2272-2283. Epub 2018 Nov 22.

Department of Neurology, Christian-Doppler-Klinik, Paracelsus Medical University, Salzburg, Austria.

Objective: The European Union-funded E-PILEPSY network (now continuing within the European Reference Network for rare and complex epilepsies [EpiCARE]) aims to harmonize and optimize presurgical diagnostic procedures by creating and implementing evidence-based guidelines across Europe. The present study evaluates the current evidence on the diagnostic accuracy of long-term video-electroencephalographic monitoring (LTM) in identifying the epileptogenic zone in epilepsy surgery candidates.

Methods: MEDLINE, Embase, CENTRAL, and ClinicalTrials. Read More

J Neurosurg 2018 Oct 1:1-9. Epub 2018 Oct 1.

1Neuroscience Research Institute, Seoul National University College of Medicine.

OBJECTIVEHow the brain supports intermediate-term preservation of memory in patients who have undergone unilateral medial temporal lobe resection (MTLR) has not yet been demonstrated. To understand the neural basis of episodic memory in the intermediate term after surgery for temporal lobe epilepsy (TLE), the authors investigated the relationship between the activation of the hippocampus (HIP) during successful memory encoding and individual memory capacity in patients who had undergone MTLR. They also compared hippocampal activation with other parameters, including structural volumes of the HIP, duration of illness, and age at seizure onset. Read More

Front Neurol 2018 13;9:889. Epub 2018 Nov 13.

Center of Epilepsy, Center for Brain Disorders Research, Capital Medical University, Beijing, China.

We proposed an improved automated high frequency oscillations (HFOs) detector that could not only be applied to various intracranial electrodes, but also automatically remove false HFOs caused by high-pass filtering. We proposed a continuous resection ratio of high order HFO channels and compared this ratio with each patient's post-surgical outcome, to determine the quantitative threshold of HFO distribution to delineate the epileptogenic zone (EZ). We enrolled a total of 43 patients diagnosed with refractory epilepsy. Read More

Pediatr Neurol 2019 Feb 24;91:50-56. Epub 2018 Oct 24.

Division of Pediatric Neurology, Epilepsy Research Institute, Severance Children's Hospital, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: Low-grade epilepsy-associated tumors (LEATs) are associated with childhood seizures that are typically drug-resistant, necessitating surgical interventions. In this study, we aimed to investigate the efficacy of surgical intervention in children with LEATs and to identify factors associated with seizure and cognitive outcomes.

Methods: We reviewed 58 children less than 18 years of age who underwent epilepsy surgery due to histopathologically confirmed LEATs and had a minimum postoperative follow-up duration of 24 months. Read More

Epilepsy Res 2019 Jan 28;149:44-52. Epub 2018 Oct 28.

Department of Neurology, Division of Child Neurology, New York-Presbyterian Hospital/ Columbia University College of Physicians and Surgeons, 180 Fort Washington Avenue, New York, New York, USA. Electronic address:

Aims: We aimed to classify ictal onset patterns (IOPs) in pediatric patients undergoing intracranial electroencephalography (IEEG) to guide surgery for refractory epilepsy. We aimed to determine if morphology of IOPs can predict surgical outcome.

Materials And Methods: We performed a retrospective review of pediatric patients who underwent epilepsy surgery guided by subdural IEEG from 2007 to 2016. Read More

J Vis Exp 2018 Nov 8(141). Epub 2018 Nov 8.

Department of Medical Sciences, Section of Pharmacology, Neuroscience Center, University of Ferrara and National Institute of Neuroscience.

Microdialysis is a well-established neuroscience technique that correlates the changes of neurologically active substances diffusing into the brain interstitial space with the behavior and/or with the specific outcome of a pathology (e.g., seizures for epilepsy). Read More

Pediatr Neurol 2018 Nov 6;88:40-47. Epub 2018 Sep 6.

Department of Neurosurgery, Haidian Hospital, Haidian District of Peking University Third Hospital, Beijing, China.

Background: Early cerebral injury has a close relationship with epilepsy and focal cortical dysplasia Ⅲd. We investigated children with focal cortical dysplasia Ⅲd who underwent surgery for epilepsy.

Methods: We selected 49 patients from among 260 pediatric patients who had undergone epilepsy surgery, analyzing their clinical materials and pathology data. Read More

Clin Neurophysiol 2019 Jan 14;130(1):20-24. Epub 2018 Nov 14.

Medical University of Vienna, Department of Pediatrics and Adolescence Medicine, Epilepsy Monitoring Unit, Währinger Gürtel 18-20, 1090 Vienna, Austria. Electronic address:

Objective: To evaluate prospectively the informative/prognostic value of epileptic discharges in the post-resection ECoGs of children with drug-resistant epilepsies and Focal Cortical Dysplasia type II (FCD-II).

Methods: Included were consecutive patients with focal epilepsies and suspected FCD-II who were planned for single-stage epilepsy surgery based on non-invasive presurgical evaluation results. Intraoperative ECoGs were recorded using a 32-channel system with strip- and/or grid-electrodes. Read More

Neurosurg Clin N Am 2019 Jan 1;30(1):43-54. Epub 2018 Nov 1.

Department of Neurological Surgery, Columbia University Medical Center, New York Presbyterian Hospital, New York, NY, USA.

The World Health Organization classifies diffuse low-grade gliomas (DLGGs) are highly epileptogenic primary brain tumors; epileptic seizures occur in more than 90% of cases. Epileptic seizures and drug resistance progress during the course of DLGGs. The glioma-related epileptogenic mechanisms are multifactorial; epileptogenic foci lie within the infiltrated peritumoral neocortex. Read More

Arch Endocrinol Metab 2018 Oct;62(5):560-565

Unidad de Endocrinología Pediátrica y Crecimiento, Pediatría, Hospital Clínico Universitario y Universidad de Santiago de Compostela, IDIS, Santiago de Compostela, Spain.

Congenital hyperinsulinism (CHI) is a heterogenous disease caused by insulin secretion regulatory defects, being ABCC8/KCNJ11 the most commonly affected genes. Therapeutic options include diazoxide, somatostatin analogues and surgery, which is curative in focal CHI. We report the case of two siblings (born two years apart) that presented themselves with hypoketotic hyperinsulinemic persistent hypoglycemias during neonatal period. Read More

Epilepsia 2019 Jan 13;60(1):85-95. Epub 2018 Nov 13.

Epileptology Department, National Institute of Health and Medical Research, Institute of System Neuroscience, Timone Hospital, Public Assistance Hospitals of Marseille, Aix-Marseille University, Marseille, France.

Objective: In this study, we seek to analyze the determinants of the intracranial electroencephalography seizure onset pattern (SOP) and the impact of the SOP in predicting postsurgical seizure outcome.

Methods: To this end, we analyzed 820 seizures from 252 consecutive patients explored by stereo-electroencephalography (total of 2148 electrodes), including various forms of focal refractory epilepsies. We used a reproducible method combining visual and time-frequency analyses. Read More

Epilepsy Behav 2018 Nov 9. Epub 2018 Nov 9.

Epilepsy Center, Neurological Clinic, University Hospital Erlangen, Germany.

Objective: Intraoperative electrocorticography (iopECoG) can contribute to delineate the resection borders of the anticipated epileptogenic zone in epilepsy surgery. However, it has several caveats that should be considered to avoid incorrect interpretation during intraoperative monitoring.

Methods: The literature on iopECoG application was reviewed, and pros and cons as well as obstacles to this technique were analyzed. Read More