117,368 results match your criteria Otology & Neurotology[Journal]


Long-term health-related quality of life after mandibular resection and reconstruction.

Eur Arch Otorhinolaryngol 2019 Mar 16. Epub 2019 Mar 16.

The Department of Otolaryngology Head and Neck Surgery, Tel-Aviv Sourasky Medical Center (affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel), Tel-Aviv, Israel.

Purpose: To compare short- and long-term quality of life (QOL) scores in patients undergoing mandibular resection and reconstruction.

Materials And Methods: All the patients who underwent resection and reconstruction of the mandible between 2000 and 2015 at a large tertiary center were retrospectively reviewed. Their QOL was measured by the University of Washington QOL questionnaire. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00405-019-05371-2DOI Listing

Physical and psychological outcomes of simple sigmoid sinus bony wall repair for pulsatile tinnitus due to sigmoid sinus wall anomalies.

Eur Arch Otorhinolaryngol 2019 Mar 16. Epub 2019 Mar 16.

Department of Otolaryngology-Head and Neck Surgery, Eye and ENT Hospital of Fudan University, Shanghai, China.

Purpose: Pulsatile tinnitus (PT) due to sigmoid sinus wall anomalies (SSWA) is a common health disorder. The purpose of this study is to investigate the efficiency of simple sigmoid sinus bony wall repair on tinnitus relief and psychological improvement.

Methods: Nine cases of PT due to SSWA were retrospectively reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00405-019-05380-1DOI Listing

Effects of diode laser setting for laryngeal surgery in a rabbit model.

Eur Arch Otorhinolaryngol 2019 Mar 16. Epub 2019 Mar 16.

Department of Otolaryngology, The University of Sao Paulo School of Medicine, Av. Dr. Enéas de Carvalho Aguiar, 255-6º andar-sala 6167, São Paulo, SP, CEP 05403-000, Brazil.

Purpose: To study the damaging effect of different diode laser settings on vocal folds 7 days after injury in a rabbit model.

Methods: Twenty-one male New Zealand white rabbits were randomized into three groups with seven animals per group. A 980-nm diode laser was used to create a single spot injury in each vocal fold. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00405-019-05344-5DOI Listing

Epigenetic changes: An emerging potential pharmacological target in allergic rhinitis.

Int Immunopharmacol 2019 Mar 14;71:76-83. Epub 2019 Mar 14.

Department of Otolaryngology-Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130041, China. Electronic address:

The importance of epigenetics has increased due to identification of its role in the pathophysiology of a number of diseases including allergic rhinitis. Amongst the different epigenetic changes in allergic retinitis, deacetylation of histone proteins by histone deacetylase (HDACs), hypermethylation of DNA by DNA methyltransferases (DNMT) and alteration in post-transcriptional process by the changes in the levels of miRNA are widely studied. Studies conducted related to allergic rhinitis have shown the elevation in the levels of HDAC1, 3 and 11 in the nasal epithelia and HDAC inhibitors have shown effectiveness in decreasing the symptoms of rhinitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.03.004DOI Listing

Craniofacial penetration by a wooden stick.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Mar 13. Epub 2019 Mar 13.

Dolphin west-Funabashi ENT clinic, 2-335-1 Katsushika, Funabashi-City, Chiba 273-0032, Japan.

Introduction: Penetrating craniofacial injuries caused by stick-like foreign bodies occur as a result of accidents particularly in children, and often lead to significant morbidity.

Case Summary: We describe a 5-year-old boy who sustained facial trauma after falling on a wooden stick which penetrated his left cheek. At the initial visit, his vital and neurological signs were normal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anorl.2018.07.008DOI Listing

"The effect of tDCS on functional connectivity in primary progressive aphasia" NeuroImage: Clinical, volume 19 (2018), pages 703-715.

Neuroimage Clin 2019 Mar 13:101734. Epub 2019 Mar 13.

Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA; Department of Cognitive Science, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address:

Transcranial direct current stimulation (tDCS) is an innovative technique recently shown to improve language outcomes even in neurodegenerative conditions such as primary progressive aphasia (PPA), but the underlying brain mechanisms are not known. The present study tested whether the additional language gains with repetitive tDCS (over sham) in PPA are caused by changes in functional connectivity between the stimulated area (the left inferior frontal gyrus (IFG)) and the rest of the language network. We scanned 24 PPA participants (11 female) before and after language intervention (written naming/spelling) with a resting-state fMRI sequence and compared changes before and after three weeks of tDCS or sham coupled with language therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2019.101734DOI Listing

Image-Guided Percutaneous Gastrostomy Tube Placement is Safe in Patients Requiring Aspirin 325 mg.

Acad Radiol 2019 Mar 14. Epub 2019 Mar 14.

Department of Radiology, Duke University School of Medicine, Durham, North Carolina.

Rationale And Objectives: Requests for gastrostomy tube placement in patients on aspirin (ASA) 325 mg are common, particularly in patients following reconstructive surgery for head and neck cancer, but periprocedural guidelines and recommendations regarding management of high dose aspirin are inconsistent. The purpose of this study was to assess the bleeding risk of percutaneous gastrostomy tube placement in patients on ASA 325 mg.

Materials And Methods: This retrospective study of 213 patients who underwent image-guided "push" percutaneous gastrostomy tube placement compared rates of significant bleeding and other secondary outcomes (including all-cause mortality within 30 days, procedure-related mortality, bowel perforation, abdominal abscess, peritonitis, aspiration pneumonia, intraprocedural airway complications, and tube dislodgement) between patients maintained on ASA 325 mg and patients not on antiplatelet or anticoagulation therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.acra.2019.02.008DOI Listing

Model-based hearing diagnostics based on wideband tympanometry measurements utilizing fuzzy arithmetic.

Hear Res 2019 Feb 28. Epub 2019 Feb 28.

Reutlingen University, Alteburgstr. 150, 72762, Reutlingen, Germany.

Today's audiometric methods for the diagnosis of middle ear disease are often based on a comparison of measurements with standard curves, that represent the statistical range of normal hearing responses. Because of large inter-individual variances in the middle ear, especially in wideband tympanometry (WBT), specificity and quantitative evaluation are greatly restricted. A new model-based approach could transform today's predominantly qualitative hearing diagnostics into a quantitative and tailored, patient-specific diagnosis, by evaluating WBT measurements with the aid of a middle-ear model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.heares.2019.02.011DOI Listing
February 2019

Removal of intraconal bullet through endoscopic transnasal surgery with image-guided navigation system 8 months after injury: a case report.

J Med Case Rep 2019 Mar 17;13(1):65. Epub 2019 Mar 17.

Division of Allergy and Rhinology, Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkla, 90110, Thailand.

Background: Lodgment of a bullet within the orbit is uncommon. The decision to remove these objects poses a challenge to surgeons due to a high risk of complications. Currently, endoscopic transnasal surgery with navigator assistance facilitates the localization of foreign bodies allowing their safe removal with minimal surrounding tissue damage or optic nerve injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13256-019-2007-xDOI Listing

Audiological evaluation of infants using mother's voice.

Int J Pediatr Otorhinolaryngol 2019 Mar 11;121:81-87. Epub 2019 Mar 11.

Department of Otolaryngology - Head & Neck Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Objectives: Hearing loss is a serious problem in infants and children because it may interfere with the development of typical speech, verbal language, and auditory and communication skills. By measuring hearing ability (thresholds) as early as possible, even as early as during infancy, effective treatment can be administered. These treatments may significantly reduce the handicap associated with hearing loss. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijporl.2019.03.005DOI Listing

Using intraoperative optical coherence tomography to image pediatric unilateral vocal fold paralysis.

Int J Pediatr Otorhinolaryngol 2019 Feb 26;121:72-75. Epub 2019 Feb 26.

Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

Objectives: Unilateral vocal fold paralysis (UVFP) impairs communication and reduces academic performance and social interactions in children. Deciding between temporary, permanent, or potentially destructive surgical interventions can be challenging, as there currently exists no reliable means of predicting vocal fold recovery or assessing the presence of vocal fold atrophy. Regarding vocal fold atrophy, optical coherence tomography (OCT) has been shown to be an appealing non-invasive alternative for accessing vocal fold structures. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01655876193010
Publisher Site
http://dx.doi.org/10.1016/j.ijporl.2019.02.039DOI Listing
February 2019
1 Read

Speech and language intervention for language impairment in patients in the FTD-ALS spectrum.

Hell J Nucl Med 2019 Jan-Apr;22 Suppl:133-146

1st Otolaryngology Dept, Medical School, Aristotle University of Thessaloniki, Aristotle University Campus, 54124, Thessaloniki, Greece.

Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease that belongs to the group of motor neuron diseases. Motor deficits like reduce in tongue strength, may coexist with cognitive deficits compatible with frontotemporal dementia (FTD), also known as frontotemporal lobar degeneration (FTLD). FTD is a neurodegenerative syndrome with two main clinical variants: behavioral (bvFTD) and language or Primary Progressive Aphasia (PPA). Read More

View Article

Download full-text PDF

Source
January 2019
1 Read

Mukonal Inhibits Cell Proliferation, Alters Mitochondrial Membrane Potential and Induces Apoptosis and Autophagy in Human CNE1 Nasopharyngeal Carcinoma Cells.

Med Sci Monit 2019 Mar 16;25:1976-1983. Epub 2019 Mar 16.

Department of Otolaryngology, The Second Hospital of Jilin University, Changchun, Jilin, China (mainland).

BACKGROUND Nasopharyngeal carcinoma results in high patient morbidity and mortality, due to early metastasis, and toxicity due to chemotherapy. Mukonal is plant-derived carbazole alkaloid that has been used in traditional Chinese medicine to treat several types of cancer. This study aimed to investigate the effects of mukonal on cell proliferation, apoptosis, autophagy, and the mitochondrial membrane potential of nasopharyngeal carcinoma cells in vitro. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.913915DOI Listing

Body changes after cancer: female cancer patients' perceived social support and their perspective on care.

Support Care Cancer 2019 Mar 15. Epub 2019 Mar 15.

Department of Clinical, Neuro- and Developmental Psychology, Faculty of Behavioral and Movement Sciences, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, van der Boechorststraat 7, Amsterdam, Netherlands.

Purpose: The aim of this study was to investigate among female cancer patients their perceived social support from health care professionals (HCPs), family and friends, and public media, and their perspective on care concerning body changes.

Methods: A study-specific questionnaire was completed by 235 female cancer patients. Descriptive statistics were used to describe social support and perspective on care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00520-019-04729-wDOI Listing

Circulating microRNAs in head and neck cancer: a scoping review of methods.

Clin Exp Metastasis 2019 Mar 14. Epub 2019 Mar 14.

Discipline of Surgery, College of Medicine and Public Health, Flinders University, Bedford Park, Australia.

Circulating microRNAs have been described as head and neck cancer biomarkers in multiple anatomical subsites including the oral cavity, nasopharynx, larynx, salivary glands and the skin. While there is an expanding volume of published literature showing the significance of individual or panels of microRNAs, the clinical validation of candidate biomarkers is lacking. The various methods used to collect, store, process and interpret these microRNAs are likely introducing bias and contributing to the inconsistent results. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10585-019-09961-6DOI Listing
March 2019
1 Read
3.491 Impact Factor

The role of F18-fluorocholine positron emission tomography/magnetic resonance imaging in localizing parathyroid adenomas.

Eur Arch Otorhinolaryngol 2019 Mar 16. Epub 2019 Mar 16.

Department of Nuclear Medicine, Assuta Medical Center, Faculty of Medicine, Tel Aviv. Affiliated with Ben Gurion University, Beersheba, Israel.

Purpose: Preoperative localization of a parathyroid adenoma is usually obtained by the combination of ultrasound and scintigraphy with technetium-99m methoxyisobutylisonitrile. We evaluated the role of F18-fluorocholine in neck positron emission tomography/magnetic resonance imaging as a novel tool for localizing parathyroid adenomas.

Methods: Patients with primary hyperparathyroidism were recruited from February 2016 to August 2017 and F18-fluorocholine positron emission tomography/magnetic resonance imaging was performed to localize the parathyroid adenoma prior to surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00405-019-05301-2DOI Listing

Outcomes in modified transoral resection of diverticula for Zenker's diverticulum.

Eur Arch Otorhinolaryngol 2019 Mar 15. Epub 2019 Mar 15.

Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.

Purpose: Transoral resection of Zenker's diverticulum (TORD) was first reported in 2010. We present results for our modified approach to transoral resection (MTORD)-full-thickness cricopharyngeal myectomy, diverticulum sac excision, and suture closure of the pharyngotomy-and evaluate its safety and efficacy compared to endoscopic stapling and open approaches.

Methods: A retrospective study was performed in patients who underwent transoral resection of Zenker's diverticulum using MTORD, endoscopic stapler-assisted diverticulotomy (ESD), or trancervical diverticulectomy (TCD) from July 2009 to August 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00405-019-05374-zDOI Listing
March 2019
1 Read

Evaluation of the effect of inferior turbinate outfracture on nasolacrimal transit time by saccharin test.

Eur Arch Otorhinolaryngol 2019 Mar 15. Epub 2019 Mar 15.

Department of Otolaryngology - Head and Neck Surgery, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

Aim: To evaluate the effect of inferior turbinate outfracture on nasolacrimal transit time by saccharin test.

Materials And Methods: Twenty patients who underwent septoplasty + unilateral radiofrequency ablation and outfracture of inferior turbinate were enrolled into study. They had no complaints about their eyes and denied previous ocular surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00405-019-05382-zDOI Listing

Grey matter activation by caloric stimulation in patients with unilateral peripheral vestibular hypofunction.

Neuroradiology 2019 Mar 16. Epub 2019 Mar 16.

Department of Pathophysiology of Hearing and Balance, Nicolaus Copernicus University, Collegium Medicum, Bydgoszcz, Poland.

Purpose: A combination of the caloric test with functional magnetic resonance imaging (fMRI) is a promising method for a comprehensive diagnostics of pathologies of the vestibular system. The aim of this study was to investigate the potential pattern of grey matter local activation in fMRI using cold and hot caloric stimulation in patients presenting unilateral peripheral vestibular injury.

Methods: Forty right-handed participants aged 27 to 56 with the diagnosis of right-sided peripheral vestibular hypofunction were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00234-019-02194-0DOI Listing

Regulation of miRNA biogenesis and histone modification by K63-polyubiquitinated DDX17 controls cancer stem-like features.

Cancer Res 2019 Mar 15. Epub 2019 Mar 15.

Cancer Genome Research Center, Linkou Chang Gung Memorial Hospital

Markers of cancer stemness predispose patients to tumor aggressiveness, drug and immunotherapy resistance, relapse, and metastasis. DDX17 is a co-factor of the Drosha-DGCR8 complex in miRNA biogenesis and transcriptional coactivator and has been associated with cancer stem-like properties. However, the precise mechanism by which DDX17 controls cancer stem-like features remains elusive. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-18-2376DOI Listing

No in vitro synergistic effect of bedaquiline combined with fluoroquinolones, linezolid, and clofazimine against extensively drug-resistant tuberculosis.

Diagn Microbiol Infect Dis 2019 Feb 19. Epub 2019 Feb 19.

Department of Tuberculosis, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China. Electronic address:

Purpose: We explored the potential synergistic effect of bedaquiline (BDQ) combined with moxifloxacin (MFX), gatifloxacin (GAT), clofazimine (CLO), and linezolid (LZD) for treatment of extensively drug-resistant tuberculosis (XDR-TB).

Methods: Of 191 XDR-TB isolates, 20 exhibiting minimal inhibitory concentration (MIC) values ≥0.063 μg/mL for BDQ were selected to study potential synergistic, additive, or antagonistic drug effects using a checkerboard assay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.diagmicrobio.2019.02.012DOI Listing
February 2019
2.457 Impact Factor

Effect of Multiple Vaccinations with Tumor Cell-Based Vaccine with Codon-Modified GM-CSF on Tumor Growth in a Mouse Model.

Cancers (Basel) 2019 Mar 15;11(3). Epub 2019 Mar 15.

Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.

Ectopic expression of codon-modified granulocyte-macrophage colony-stimulating factor (cGM-CSF) in TC-1 cells (TC-1/cGM-CSF), a model cell line for human papillomavirus (HPV)-infected cervical cancer cells, increased the expression level of GM-CSF and improved the efficacy of tumor cell-based vaccines in a cervical cancer mouse model. The number of vaccine doses required to induce a long-term immune response in a cervical cancer mouse model is poorly understood. Here, we investigated one, three, and five doses of the irradiated TC-1/cGM-CSF vaccine to determine which dose was effective in inducing a greater immune response and the suppression of tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11030368DOI Listing

Abscisic Acid Regulates the 3-Hydroxy-3-methylglutaryl CoA Reductase Gene Promoter and Ginsenoside Production in Hairy Root Cultures.

Int J Mol Sci 2019 Mar 15;20(6). Epub 2019 Mar 15.

Department of Pharmaceutical Biotechnology, Medical University of Lodz, Muszyńskiego l, 90-151 Lodz, Poland.

hairy root cultures synthesize triterpenoid saponins named ginsenosides, that have multidirectional pharmacological activity. The first rate-limiting enzyme in the process of their biosynthesis is 3-hydroxy-3-methylglutaryl CoA reductase (HMGR). In this study, a 741 bp fragment of the gene (), consisting of a proximal promoter, 5'UTR (5' untranslated region) and 5'CDS (coding DNA sequence) was isolated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20061310DOI Listing
March 2019
1 Read

Subglottic stenosis in children: Our experience at a pediatric tertiary center for 8 years in South Korea.

Int J Pediatr Otorhinolaryngol 2019 Feb 27;121:64-67. Epub 2019 Feb 27.

Department of Otolaryngology - Head and Neck Surgery, College of Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea. Electronic address:

Objective: The incidence of SGS has been reported to be less than 8% after endotracheal intubation. Therefore there is an increasing trend in the number of patients with acute acquired SGS due to mechanical ventilation in the intensive care unit. However, there have been no reports describing the treatment of SGS in children in South Korea. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijporl.2019.02.044DOI Listing
February 2019

Binaural hearing advantages for children with bimodal fitting.

Int J Pediatr Otorhinolaryngol 2019 Feb 27;121:58-63. Epub 2019 Feb 27.

New Hearing Technologies Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Objectives: Bimodal fitting (BF) allows children with cochlear implant to benefit from binaural hearing advantages. Three major binaural hearing advantages, which enhance hearing function of people with normal hearing, are head shadow effect (HSE), binaural squelch effect (BSQ) and binaural summation effect (BSU). This study in pediatric patients attempting to measure the auditory benefits of bimodal stimulation in children with long-standing use of a cochlear implant (CI), and residual hearing on the contralateral side. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijporl.2019.02.043DOI Listing
February 2019

Raising the Bar at GTMB.

Authors:
Garth D Ehrlich

Genet Test Mol Biomarkers 2019 Mar;23(3):151-152

1 Departments of Microbiology and Immunology, and Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/gtmb.2019.0042DOI Listing

Immunotherapy Approaches Beyond PD-1 Inhibition: the Future of Cellular Therapy for Head and Neck Squamous Cell Carcinoma.

Curr Treat Options Oncol 2019 Mar 14;20(4):31. Epub 2019 Mar 14.

Division of Medical Oncology, Department of Medicine, University of Washington, 825 Eastlake Ave East, Mail Stop K2-231, Seattle, WA, 98109, USA.

Opinion Statement: In a span of a few years, the surprising early successes of programmed cell death 1 (PD-1) inhibitors across a vast range of tumor types have transformed our understanding of cancer immunogenicity and provided proof of principle that T cells, if manipulated, can mediate meaningful tumor regression. In head and neck cancer, only a minority of patients respond to PD-1 therapy, but these small outcomes have fueled the enthusiasm for the next generation of immunotherapy-adoptive cell therapy-which employs recent advances in genetic engineering and cell culturing methods to generate T cells with enhanced anti-tumor efficacy for infusion back into the patient. Head and neck cancer is comprised of biologically distinct cancers, HPV-positive and HPV-negative, and the clinical responses to PD-1 inhibitors in both HPV-positive and HPV-negative head and neck patients have showcased better than any other cancer type that there are distinct pathways to immunogenicity that may lend themselves to different therapeutic approaches. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11864-019-0630-9DOI Listing

Contemporary Treatment of Locally Advanced Oral Cancer.

Authors:
David Kim Ryan Li

Curr Treat Options Oncol 2019 Mar 14;20(4):32. Epub 2019 Mar 14.

Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, PV01, Portland, OR, 97239, USA.

Opinion Statement: At our institution, locally advanced oral cancer is most commonly treated with surgical resection, immediate reconstruction, and adjuvant radiotherapy with or without concurrent systemic therapy depending on final surgical pathologic analysis. There are patients with markedly advanced local or regional disease who unfortunately will have a low probability of cure. We counsel these patients on induction chemotherapy, emphasizing that this is unlikely to result in a smaller volume of surgical resection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11864-019-0631-8DOI Listing

Osteitis in Chronic Rhinosinusitis.

Curr Allergy Asthma Rep 2019 Mar 14;19(5):24. Epub 2019 Mar 14.

Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.

Purpose Of Review: Osteitis is recognized as a common factor in recalcitrant chronic rhinosinusitis (CRS). There is evidence for the association of osteitis with revision surgeries and CRS severity, in terms of higher Lund-Mackay scores. This is a narrative review on the osteitis in CRS patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11882-019-0855-5DOI Listing

Publisher Correction: Metabolic reprogramming of stromal fibroblasts by melanoma exosome microRNA favours a pre-metastatic microenvironment.

Sci Rep 2019 Mar 15;9(1):4959. Epub 2019 Mar 15.

Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-37179-1DOI Listing

Accidental swallowing of dental implant: complication of transnasal endoscopic removal from maxillary sinus.

J Oral Implantol 2019 Mar 15. Epub 2019 Mar 15.

2 Chonnam National University Hospital Clinical assistant professor Otolaryngology-Head and Neck Surgery.

Transnasal endoscopic removal of displaced dental implants in the maxillary sinus can be done easily under local anesthesia. However, very little is known regarding the precaution of this technique. In this report, we present a 63-year-old man visited otolaryngologic department with displaced dental implant in the maxillary sinus. Read More

View Article

Download full-text PDF

Source
http://www.joionline.org/doi/10.1563/aaid-joi-D-18-00231
Publisher Site
http://dx.doi.org/10.1563/aaid-joi-D-18-00231DOI Listing
March 2019
1 Read

Zebrafish Model for Non-Syndromic X-linked Sensorineural Deafness, DFNX1.

Anat Rec (Hoboken) 2019 Mar 15. Epub 2019 Mar 15.

Department of Biology, University of Miami, Coral Gables, Florida 33146, USA.

Hereditary deafness is often a neurosensory disorder and affects the quality of life of humans. Only three X-linked genes (POU class 3 homeobox 4 (POU3F4), phosphoribosylpyrophosphate synthetase 1 (PRPS1), and small muscle protein X-linked (SMPX)) are known to be involved in non-syndromic hearing loss. Four PRPS1 missense mutations have been found to associate with X-linked non-syndromic sensorineural deafness (DFNX1/DFN2) in humans. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ar.24115DOI Listing

Temporal bone carcinoma: Treatment patterns and survival.

Laryngoscope 2019 Mar 15. Epub 2019 Mar 15.

Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa.

Objectives/hypothesis: Carcinomas of the temporal bone are rare, and appropriate treatment, staging, and survival data are limited. This study evaluates clinical characteristics and survival rates for patients with temporal bone carcinoma treated with resection at a single tertiary-care institution, with a focus on the outcomes of patients with locally advanced disease including skull base and/or dural invasion.

Study Design: Retrospective chart review. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lary.27877DOI Listing

Engineering an immunomodulatory drug-eluting stent to treat laryngotracheal stenosis.

Biomater Sci 2019 Mar 15. Epub 2019 Mar 15.

Johns Hopkins School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA. and Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institution, 600 N. Wolfe St., Baltimore, MD 21287, USA.

Objective: Develop a drug-eluting stent construct with a reliable drug-release profile and adequate mechanically stability for a trial in a small animal model of laryngotracheal stenosis (LTS), a debilitating pathologic narrowing of the airway leading to significant shortness of breath.

Methods: Biodegradable, biocompatible stents containing 1.0% rapamycin made of PLLA-PCL (70% Poly-l-Lactide and 30% Polycaprolactone blend) and 50 : 50 PDLGA (Poly(dl-lactide-co-glycolide)) were compared. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8bm01623bDOI Listing

Expression of IL-25, IL-33, and Thymic Stromal Lymphopoietin in Nasal Polyp Gland Duct Epithelium in Patients With Chronic Rhinosinusitis.

Am J Rhinol Allergy 2019 Mar 15:1945892419835333. Epub 2019 Mar 15.

1 Department of Otolaryngology-Head and Neck Surgery, Nihon University School of Medicine, Tokyo, Japan.

Background: Nasal polyps accompany eosinophilic chronic rhinosinusitis (ECRS). Cytokines, including interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) expressed in nasal mucosa have been implicated in polyp pathogenesis. We investigated the role of nasal polyp epithelium cytokine expression in eosinophilic infiltration in ECRS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1945892419835333DOI Listing

SMARCB1-Deficient Sinonasal Carcinoma: A Case Report and Discussion of the Clinical Implications.

Ann Otol Rhinol Laryngol 2019 Mar 15:3489419836668. Epub 2019 Mar 15.

2 Division of Otolaryngology, University of Vermont Medical Center, Burlington, Vermont, USA.

Objective:: SMARCB1-deficient sinonasal tract carcinomas are an emerging subset of rare tumors recently described in the literature, with less than 100 reported cases. Given the aggressive nature of this tumor, timely diagnosis is especially important. We present a case report of a SMARCB1-deficient carcinoma of the sinonasal tract. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0003489419836668DOI Listing

Minimal Clinically Important Difference of the Standardized Cosmesis and Health Nasal Outcomes Survey.

Aesthet Surg J 2019 Mar 9. Epub 2019 Mar 9.

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA.

Background: The minimal clinically important difference (MCID) for the Standardized Cosmesis and Health Nasal Outcomes Survey (SCHNOS) has not been determined.

Objective: To define the MCID for both domains of the SCHNOS questionnaire.

Methods: This prospective cohort study included patients who underwent functional, cosmetic, or combined rhinoplasty operation from June 2017-June 2018 at a tertiary referral center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/asj/sjz070DOI Listing

Applications of Lgr5-Positive Cochlear Progenitors (LCPs) to the Study of Hair Cell Differentiation.

Front Cell Dev Biol 2019 19;7:14. Epub 2019 Feb 19.

Department of Otolaryngology, Harvard Medical School, Boston, MA, United States.

The mouse cochlea contains approximately 15,000 hair cells. Its dimensions and location, and the small number of hair cells, make mechanistic, developmental and cellular replacement studies difficult. We recently published a protocol to expand and differentiate murine neonatal cochlear progenitor cells into 3D organoids that recapitulate developmental pathways and can generate large numbers of hair cells with intact stereociliary bundles, molecular markers of the native cells and mechanotransduction channel activity, as indicated by FM1-43 uptake. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcell.2019.00014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401656PMC
February 2019

-Induced Barrier Disruption Correlates With Elastase Activity and Marks Chronic Rhinosinusitis Severity.

Front Cell Infect Microbiol 2019 27;9:38. Epub 2019 Feb 27.

Department of Surgery-Otolaryngology Head and Neck Surgery, University of Adelaide, Adelaide, SA, Australia.

causes severe chronic respiratory diseases and is associated with recalcitrant chronic rhinosinusitis (CRS). exoproteins contain virulence factors and play important roles in the pathogenicity of , however their role in CRS pathophysiology remains unknown. We isolated clinical isolates (CIs) and obtained clinical information from 21 CRS patients. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fcimb.2019.00038
Publisher Site
http://dx.doi.org/10.3389/fcimb.2019.00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400838PMC
February 2019
3 Reads
2.620 Impact Factor

High-risk type human papillomavirus infection and p16 expression in laryngeal cancer.

Infect Agent Cancer 2019 5;14. Epub 2019 Mar 5.

1Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, 903-0215 Japan.

Background: Oropharyngeal cancers associated with high-risk type human papillomavirus (HR-HPV) infection have better prognosis than virus negative cancers. Similarly, the HPV status in laryngeal cancer (LC) may be associated with better outcome.

Methods: Samples from 88 patients with LC were investigated using the polymerase chain reaction (PCR) and p16 immunohistochemistry for HR-HPV analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13027-019-0224-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402092PMC

Cellular Differences in the Cochlea of CBA and B6 Mice May Underlie Their Difference in Susceptibility to Hearing Loss.

Front Cell Neurosci 2019 27;13:60. Epub 2019 Feb 27.

Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Hearing is an extremely delicate sense that is particularly vulnerable to insults from environment, including drugs and noise. Unsurprisingly, mice of different genetic backgrounds show different susceptibility to hearing loss. In particular, CBA/CaJ (CBA) mice maintain relatively stable hearing over age while C57BL/6J (B6) mice show a steady decline of hearing, making them a popular model for early onset hearing loss. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fncel.2019.00060
Publisher Site
http://dx.doi.org/10.3389/fncel.2019.00060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400987PMC
February 2019
1 Read

Hearing impairment locus heterogeneity and identification of PLS1 as a new autosomal dominant gene in Hungarian Roma.

Eur J Hum Genet 2019 Mar 14. Epub 2019 Mar 14.

Department of Molecular and Human Genetics, Center for Statistical Genetics, Baylor College of Medicine, Houston, TX, USA.

Roma are a socially and culturally distinct isolated population with genetically divergent subisolates, residing mainly across Central, Southern, and Eastern Europe. We evaluated the genetic etiology of hearing impairment (HI) in 15 Hungarian Roma families through exome sequencing. A family with autosomal dominant non-syndromic HI segregating a rare variant in the Calponin-homology 2 domain of PLS1, or Plastin 1 [p. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41431-019-0372-yDOI Listing

Drug repositioning in head and neck squamous cell carcinoma: An integrated pathway analysis based on connectivity map and differential gene expression.

Pathol Res Pract 2019 Mar 5. Epub 2019 Mar 5.

Department of Otolaryngology Head and Neck Surgery, NO.303 Hospital of PLA, Nanning, Guangxi Zhuang Autonomous Region, China. Electronic address:

The severe damage to health and social burden caused by head and neck squamous cell carcinoma (HNSCC) generated an urgent need to develop novel anti-cancer therapy. Currently, drug repositioning has risen in responses to the proper time as an efficient approach to invention of new anti-cancer therapies. In the present study, we aimed to screen candidate drugs for HNSCC by integrating HNSCC-related pathways from differentially expressed genes (DEGs) and drug-affected pathways from connectivity map (CMAP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prp.2019.03.007DOI Listing

Results of endoscopic transcanal tympanoplasty performed by a young surgeon in a secondary hospital.

Braz J Otorhinolaryngol 2019 Feb 28. Epub 2019 Feb 28.

Siirt State Hospital, Department of Otolaryngology, Siirt, Turkey.

Introduction: Tympanoplasty is performed to close the tympanic membrane perforation and recover the hearing level of patients with non-suppurative chronic otitis media. Endoscopic tympanoplasty has recently been increasingly preferred by ear nose and throat surgeons to treat tympanic membrane perforations.

Objective: The aim of this study is to discuss the outcomes of patients undergoing endoscopic tympanoplasty performed by a young surgeon in a secondary hospital in the context of the literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bjorl.2018.12.012DOI Listing
February 2019

Quality of life after mandibulectomy: the impact of the resected subsite.

Int J Oral Maxillofac Surg 2019 Mar 11. Epub 2019 Mar 11.

Department of Otolaryngology, Head & Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.

The purpose of this study was to identify the factors that impact the quality of life (QOL) scores of patients undergoing mandibulectomy. All patients with a diagnosis of an oral cavity neoplasm involving the mandible who underwent a mandibulectomy between January 1, 2000 and December 31, 2015 and completed a University of Washington QOL questionnaire (UW-QOL) were included in the study. Fifty-eight patients fulfilled all inclusion criteria and completed the UW-QOL questionnaire. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09015027193009
Publisher Site
http://dx.doi.org/10.1016/j.ijom.2019.02.013DOI Listing
March 2019
1 Read

Standardised profiling for tinnitus research: The European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ).

Hear Res 2019 Mar 2. Epub 2019 Mar 2.

NIHR Nottingham Biomedical Research Centre, 113 The Ropewalk, Nottingham, NG1 5DU, UK; Hearing Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Building 40 University Park, Nottingham, NG7 2RD, UK; Nottingham University Hospitals NHS Trust, Queens Medical Centre, Derby Road, Nottingham, NG7 2UH, UK; University of Nottingham Malaysia, Jalan Broga, 43500, Semeniyh, Selangor Darul Ehsan, Malaysia.

Background: The heterogeneity of tinnitus is substantial. Its numerous pathophysiological mechanisms and clinical manifestations have hampered fundamental and treatment research significantly. A decade ago, the Tinnitus Research Initiative introduced the Tinnitus Sample Case History Questionnaire, a case history instrument for standardised collection of information about the characteristics of the tinnitus patient. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.heares.2019.02.017DOI Listing

Free versus pedicled flaps for reconstruction of head and neck cancer defects: a systematic review.

J Otolaryngol Head Neck Surg 2019 Mar 14;48(1):13. Epub 2019 Mar 14.

Division of Otolaryngology - Head & Neck Surgery service, Université de Montréal, Montreal, QC, Canada.

Objective: The present review focuses on comparative studies of reconstruction with free flaps (FF) versus pedicled flaps (PF) after oncologic resection.

Method: A systematic review was developed in compliance with PRISMA guidelines and performed using the Pubmed, Medline, EMBASE, Amed and Biosis databases.

Results: A total of 30 articles were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40463-019-0334-yDOI Listing

Lidocaine safety after saphenous vein tumescent anesthesia.

Phlebology 2019 Mar 14:268355519836834. Epub 2019 Mar 14.

3 Department of Otolaryngology - Head & Neck Surgery, University of Cincinnati, Cincinnati, USA.

Objectives: For endovenous thermal ablation of the saphenous veins, tumescent lidocaine anesthesia is often used. Unfortunately, information is sparse on the pharmacokinetics of lidocaine absorption and its maximum safe dose. The aim of this study was to evaluate plasma concentration of lidocaine on 12 lead electrocardiograms (ECGs) and symptoms over time after the administration of tumescent lidocaine during endovenous thermal ablation procedures in healthy volunteers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0268355519836834DOI Listing

Otolaryngology.

Am J Rhinol Allergy 2019 Mar;33(2):226

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1945892418820478DOI Listing

Procalcitonin as a Biomarker in Rhinosinusitis: A Systematic Review.

Am J Rhinol Allergy 2019 Mar 3;33(2):103-112. Epub 2018 Dec 3.

1 Department of Otolaryngology - Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Objectives: (1) To describe the existing literature on procalcitonin (PCT) as a biomarker in patients with acute rhinosinusitis (ARS), (2) to analyze outcomes in ARS patients who were treated with PCT-guided therapy versus traditional management, and (3) to compare PCT to other biomarkers used in diagnosis of bacterial ARS. Data Sources: PubMed and Embase. Review Methods: A systematic search in the PubMed and Embase databases was performed to identify studies related to PCT as a biomarker in ARS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1945892418810293DOI Listing