29,894 results match your criteria Otitis Media


A2ML1 and otitis media: novel variants, differential expression and relevant pathways.

Hum Mutat 2019 Apr 22. Epub 2019 Apr 22.

Department of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, Colorado, USA.

A genetic basis for otitis media is established, however the role of rare variants in disease etiology is largely unknown. Previously a duplication variant within A2ML1 was identified as a significant risk factor for otitis media in an indigenous Filipino population and in US children. In this report exome and Sanger sequencing was performed using DNA samples from the indigenous Filipino population, Filipino cochlear implantees, US probands, and Finnish and Pakistani families with otitis media. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/humu.23769
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http://dx.doi.org/10.1002/humu.23769DOI Listing
April 2019
1 Read

Otitis Media in Childhood and Disease in Adulthood: A 40-Year Follow-Up Study.

Ear Hear 2019 Apr 16. Epub 2019 Apr 16.

Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway.

Objectives: The pathogenesis of chronic suppurative otitis media (CSOM) includes complex interactions between microbial, immunologic, and genetic factors. To our knowledge, no study has focused on the association between childhood otitis media, immune regulation, inflammatory conditions, and chronic disease in adulthood. The present study aims to assess whether CSOM in childhood predicts immune-related inflammatory disorders or cardiovascular disease in adulthood. Read More

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http://dx.doi.org/10.1097/AUD.0000000000000729DOI Listing
April 2019
2 Reads

The p.P479L variant in CPT1A is associated with infectious disease in a BC First Nation.

Paediatr Child Health 2019 May 6;24(2):e111-e115. Epub 2018 Aug 6.

Department of Pathology and Laboratory Medicine, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia.

Background: The hepatic carnitine palmitoyltransferase I () p.P479L variant is common in Aboriginal populations across coastal British Columbia, Alaska, the Canadian North, and Greenland. While the high frequency of this variant suggests positive selection, other studies have shown an association with sudden unexpected death in infancy and infection. Read More

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https://academic.oup.com/pch/article/24/2/e111/5067175
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http://dx.doi.org/10.1093/pch/pxy106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462176PMC
May 2019
2 Reads

Early Otorrhea Rates: A Randomized Trial of Ciprofloxacin versus Saline Drops after Tympanostomy Tubes.

Ann Otol Rhinol Laryngol 2019 Apr 16:3489419843550. Epub 2019 Apr 16.

1 Cleveland Clinic Otolaryngology, Cleveland, Ohio, USA.

Objective: The objectives of this study are to evaluate incidence, duration, and quality of life (QOL) impact of early tympanostomy tube otorrhea and tube patency when comparing topical ciprofloxacin versus normal saline use in the perioperative period.

Methods: Overall, 200 patients undergoing tube placement between November 19, 2015, and September 12, 2016, were randomized to intraoperative plus 5 days of either topical ciprofloxacin or normal saline. Parents or caregivers reported the incidence, duration, and QOL impact of early otorrhea via 4 weekly surveys. Read More

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http://dx.doi.org/10.1177/0003489419843550DOI Listing

[A multi-center retrospective study of ossiculoplasty surgery under oto-endoscope in 45 cases of conductive hearing loss with intact tympanic membrane].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;54(4):257-261

Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.

To explore the efficacy of ossiculoplasty surgery under oto-endoscope in patients of conductive hearing loss with intact tympanic membrane. A retrospective study was conducted. The clinical data of 45 patients with conductive hearing loss who had undergone simple ossiculoplasty surgery between October 2015 and December 2017 from five hospitals in China (West China Hospital of Sichuan University, General Hospital of the People's Liberation Army, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Xijing Hospital, Fourth Military Medical University and Shenzhen Sixth People's Hospital) were collected. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.04.004DOI Listing
April 2019
3 Reads

[A multi-center clinical retrospective study on the therapeutic effect of endoscopic myringoplasty].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;54(4):245-250

Department of Otorhinolaryngology Head and Neck Surgery, Shaanxi Provincial People's Hospital, Xi'an 710068, China.

To analyze the therapeutic effect of endoscopic myringoplasty. A retrospective analysis of 523 patients with chronic otitis media who underwent endoscopic myringoplasty between June 2016 and June 2017 in eight tertiary hospitals in China. Among all the patients, 256 were male and 267 were female, aged from 18 to 68 years old. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.04.002DOI Listing

Impacted Incus Foreign Body in the Eustachian Tube.

Iran J Otorhinolaryngol 2019 Mar;31(103):123-126

Department of Otorhinolaryngology , Grant Government Medical College and Sir J.J Hospitals, Mumbai, India.

Introduction: Foreign bodies in the external auditory canal are fairly common, and tend to be seeds, toys, or insects. However, foreign bodies in the middle ear are rarer and are generally accidental or iatrogenic. Although there are numerous reports regarding fascinating foreign bodies in the ear, the same cannot be said about foreign bodies in the Eustachian tube (ET). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449523PMC
March 2019
1 Read

Genetic characteristics and antibiotic resistance of Haemophilus influenzae isolates from pediatric patients with acute otitis media after introduction of 13-valent pneumococcal conjugate vaccine in Japan.

J Infect Chemother 2019 Apr 12. Epub 2019 Apr 12.

Department of Infectious Diseases, National Cancer Center Hospital, Tokyo, Japan.

Acute otitis media (AOM) occurs commonly in pediatric populations. We examined resistance genotype, antibiotic susceptibility, quinolone (QL) resistance, and multilocus sequence type (MLST) among Haemophilus influenzae isolates causing AOM following introduction of pneumococcal conjugate vaccines in Japan. The AOM surveillance group included 69 participating otolaryngologists. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.03.019DOI Listing

Effect of Water Precautions on Otorrhea Incidence after Pediatric Tympanostomy Tube: Randomized Controlled Trial Evidence.

Otolaryngol Head Neck Surg 2019 Apr 16:194599819844487. Epub 2019 Apr 16.

8 Department of Otolaryngology, SUNY Downstate Medical Center, Brooklyn, New York, USA.

Objectives: Tympanostomy with ventilation tube insertion is the most common otologic surgery. Many surgeons recommend water precautions, although its utility is questioned. We aimed to investigate if water precautions reduce the rate of otorrhea after transtympanic tube insertion. Read More

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http://dx.doi.org/10.1177/0194599819844487DOI Listing
April 2019
1 Read

NLRP3/ASC/Caspase-1 axis and serine protease activity are involved in neutrophil IL-1β processing during Streptococcus pneumoniae infection.

Biochem Biophys Res Commun 2019 Apr 11. Epub 2019 Apr 11.

College of Animal Science and Technology, Southwest University, Chongqing, 400715, China. Electronic address:

Streptococcus pneumoniae is a pathogenic bacterium that can cause severe invasive diseases, such as pneumonia, otitis media and meningitis. The pro-inflammatory cytokine, IL-1β, has been reported to play important role in host defense against S. pneumoniae. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.004DOI Listing

Evaluation of Type III Tympanoplasty Using Cartilage Ossiculoplasty in Cholesteatoma Ear Surgery.

Ear Nose Throat J 2019 Apr 11:145561319840546. Epub 2019 Apr 11.

1 Department of Otorhinolaryngology-Head & Neck Surgery, Lady Hardinge Medical College & Associated Hospitals, Shaheed Bhagat Singh Marg, New Delhi, India.

This prospective observational study evaluates the role of tympanoplasty type III in cholesteatoma ear disease during same sitting with mastoid surgery using cartilage ossiculoplasty. Forty patients of chronic suppurative otitis media-cholesteatoma disease were recruited in the study. All the patients had extensive cholesteatoma and underwent canal wall down mastoid surgery. Read More

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http://dx.doi.org/10.1177/0145561319840546DOI Listing
April 2019
1 Read
0.881 Impact Factor

A model of chronic, transmissible Otitis Media in mice.

PLoS Pathog 2019 04 10;15(4):e1007696. Epub 2019 Apr 10.

Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, United States of America.

Infection and inflammation of the middle ears that characterizes acute and chronic otitis media (OM), is a major reason for doctor visits and antibiotic prescription, particularly among children. Nasopharyngeal pathogens that are commonly associated with OM in humans do not naturally colonize the middle ears of rodents, and experimental models in most cases involve directly injecting large numbers of human pathogens into the middle ear bullae of rodents, where they induce a short-lived acute inflammation but fail to persist. Here we report that Bordetella pseudohinzii, a respiratory pathogen of mice, naturally, efficiently and rapidly ascends the eustachian tubes to colonize the middle ears, causing acute and chronic histopathological changes with progressive decrease in hearing acuity that closely mimics otitis media in humans. Read More

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http://dx.plos.org/10.1371/journal.ppat.1007696
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http://dx.doi.org/10.1371/journal.ppat.1007696DOI Listing
April 2019
3 Reads

Rare case of a 3-year-old with skull base osteomyelitis: lessons to be learnt.

BMJ Case Rep 2019 Apr 8;12(4). Epub 2019 Apr 8.

Ear, Nose and Throat Surgery, Lister Hospital, Stevenage, UK.

Skull base osteomyelitis (SBO) is a serious and rare condition most commonly seen in elderly diabetic or immunocompromised patients as a complication of otitis externa. We present the case of a previously healthy 3-year-old girl who presented to the paediatric emergency department with vomiting, fever, lethargy, headache and left-sided facial nerve palsy. The initial CT head revealed left-sided otitis media with otomastoiditis and she was managed with intravenous antibiotics and myringotomy with grommet insertion with initial improvement. Read More

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http://dx.doi.org/10.1136/bcr-2018-228026DOI Listing
April 2019
3 Reads

The Association Between ENT Diseases and Obesity in Pediatric Population: A Systemic Review of Current Knowledge.

Ear Nose Throat J 2019 Apr 9:145561319840819. Epub 2019 Apr 9.

1 Department and Clinic of Otolaryngology, Head and Neck Surgery, Medical University in Wrocław, Wrocław, Poland.

Obesity in pediatric population is an important global problem. The prevalence of obesity in children is dramatically rising. According to World Health Organization, about 41 million children under the age of 5 years are obese or overweight worldwide. Read More

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http://dx.doi.org/10.1177/0145561319840819DOI Listing
April 2019
1 Read

Recurrent Facial Nerve Paresis in a Child With Chronic Otitis Media With Effusion.

Ear Nose Throat J 2019 Apr 7:145561319839933. Epub 2019 Apr 7.

1 Department of Otolaryngology, SUNY Upstate Medical University, Syracuse, NY, USA.

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http://dx.doi.org/10.1177/0145561319839933DOI Listing

A Healthy Toddler With Fever and Lethargy.

Pediatrics 2019 Apr 5. Epub 2019 Apr 5.

Division of Hospital Medicine and

A 21-month-old previously healthy girl presented to the emergency department initially with fever, rhinorrhea, and poor oral intake. She was subsequently discharged from the hospital on amoxicillin for treatment of acute otitis media but presented hours later on the same day with continued poor oral intake, decreased urine output, and lethargy. The patient was afebrile on examination without a focal source of infection or evidence of meningismus, but she was lethargic and minimally responsive to pain and had reduced strength in the upper and lower extremities. Read More

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http://dx.doi.org/10.1542/peds.2018-0412DOI Listing
April 2019
1 Read

Preventing unnecessary tympanostomy tube placement in children.

Int J Pediatr Otorhinolaryngol 2019 Mar 28;122:40-43. Epub 2019 Mar 28.

University of Texas Medical Branch Department of Otolaryngology, 7.104 John Sealy Annex, 301 University Boulevard, Galveston, TX, 77555, USA. Electronic address:

Objective: In 2013 the American Academy of Otolaryngology published tympanostomy tube guidelines for children; Action Statement 6 recommends against tube placement without middle ear effusion (MEE) at time of assessment. To date, little research has directly evaluated this recommendation in reducing the need for ear tubes. We evaluated the effectiveness of this recommendation and potential risk factors that influence the success of watchful waiting. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.03.031DOI Listing

Reversible conductive hearing impediments among patients with severe brain injury.

Disabil Rehabil 2019 Apr 5:1-4. Epub 2019 Apr 5.

c Department of Otolaryngology-Head and Neck Surgery, Sackler School of Medicine , Tel Aviv University, Assuta Ashdod University Hospital , Ashdod , Israel.

Purpose: Rehabilitation of patients with severe traumatic brain injury may include auditory stimuli. Hampering the function of the external, middle ear or Eustachian tube generates a conductive auditory deficit up to 35 dB that may potentially hinder auditory rehabilitation. The objective was to evaluate the incidence of conductive hearing impediments among patients with severe brain injury. Read More

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http://dx.doi.org/10.1080/09638288.2019.1588923DOI Listing
April 2019
1 Read
1.837 Impact Factor

Human bocaviruses and paediatric infections.

Lancet Child Adolesc Health 2019 Apr 1. Epub 2019 Apr 1.

Department of Paediatrics, Turku University Hospital and University of Turku, Turku, Finland.

Human bocavirus 1 (HBoV1), belonging to the Parvoviridae family, was discovered in 2005, in nasopharyngeal samples from children with respiratory tract infections. Three additional bocaviruses, HBoV2-4, were discovered in 2009-10. These viruses have mainly been found in faecal samples and their role in human diseases is still uncertain. Read More

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http://dx.doi.org/10.1016/S2352-4642(19)30057-4DOI Listing
April 2019
2 Reads

Epidemiology and burden of influenza in healthy children aged 6 to 35 months: analysis of data from the placebo arm of a phase III efficacy trial.

BMC Infect Dis 2019 Apr 4;19(1):308. Epub 2019 Apr 4.

Netherlands Institute for Health Services Research, Utrecht, The Netherlands.

Background: Despite World Health Organization recommendations, in many countries young children are not targeted for influenza vaccination. To help inform influenza vaccination policy, we examined the occurrence and burden of influenza in healthy children aged 6 to 35 months using data from a recent phase III placebo-controlled influenza vaccine trial conducted in countries in the Northern and Southern Hemispheres.

Methods: This was an analysis of data from participants included in the placebo arm of a phase III clinical trial in healthy children aged 6 to 35 months (EudraCT no. Read More

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http://dx.doi.org/10.1186/s12879-019-3920-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449994PMC
April 2019
3 Reads

A case of de novo 18p deletion syndrome with panhypopituitarism.

Ann Pediatr Endocrinol Metab 2019 Mar 31;24(1):60-63. Epub 2019 Mar 31.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Deletion on the short arm of chromosome 18 is a rare disorder characterized by intellectual disability, growth retardation, and craniofacial malformations (such as prominent ears, microcephaly, ptosis, and a round face). The phenotypic spectrum is wide, encompassing a range of abnormalities from minor congenital malformations to holoprosencephaly. We present a case of a 2-year-old girl with ptosis, a round face, broad neck with low posterior hairline, short stature, and panhypopituitarism. Read More

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http://dx.doi.org/10.6065/apem.2019.24.1.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449612PMC
March 2019
5 Reads

[The algorithm of the treatment and diagnostic strategy for the treatment the children presenting with acute mastoiditis].

Vestn Otorinolaringol 2019 ;84(1):28-30

Department of Otorhinolaryngology, Pediatric Faculty of the N.I. Pirogov Russian National Research Medical University, Moscow, Russia, 117997; Morozovskaya City Children's Clinical Hospital, Moscow Health Department, Moscow, Russia, 119049.

This article was designed to report the results of the analysis of the cases of chronic otitis media complicated by mastoiditis in the children admitted to the Morozovskaya City Children's Clinical Hospital for the examination and treatment during the period from 2009 till 2017. The objective of the present study was to evaluate the clinical significance and the optimal time schedule of computed tomography (CT) of the temporal bones in the patients with suspicion of mastoiditis for the determination of the indications for their surgical treatment. All the patients were divided into three groups differing in the severity of clinical manifestations of the disease. Read More

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http://dx.doi.org/10.17116/otorino20198401128DOI Listing
January 2019
1 Read

[Evaluation of structural changes of bone in chronic purulent otitis media].

Vestn Otorinolaringol 2019 ;84(1):12-17

MAUZ 'GKB #1', Chelyabinsk, Russia, 454092.

Fragments of bone tissue of the temporal bone, obtained during reconstructive-sanitizing operations in patients with chronic purulent otitis media, were studied by light and electron microscopy. An analysis was made of the degree of structural changes in bone tissue in chronic inflammation at the cellular and tissue levels after a histomorphological study in microwave decalcification. The method of diagnosis reliably allowed to differentiate the diseases characterized by the rarefaction of bone tissue, due to chronic inflammation, and also to determine the processes of transformation of bone tissue. Read More

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http://dx.doi.org/10.17116/otorino20198401112DOI Listing
January 2019
3 Reads

[The role of stapedoplasty in the treatment of hearing impairment in the patients presenting with tympanosclerosis].

Vestn Otorinolaringol 2019 ;84(1):4-11

L.I. Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow Health Department, Moscow, Russia, 117152.

The present study included the examination and surgical treatment of 50 adult patients presenting with tympanosclerotic fixation of the stirrup. The patients comprising the first subgroup (n=25) underwent the two-stage treatment during the period from 1990 to 2009. The final phase of the treatment consisted of the implantation of different kinds of stirrup prostheses placed on the venous autograft that closed the oval window of the vestibule following partial or total instrumental stapedectomy. Read More

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http://dx.doi.org/10.17116/otorino2019840114DOI Listing
January 2019
1 Read

Quality of life and functional results in canal wall down vs canal wall up mastoidectomy.

Acta Otorhinolaryngol Ital 2019 Feb;39(1):53-60

Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

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http://dx.doi.org/10.14639/0392-100X-2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444168PMC
February 2019

Assessing ototoxicity and patients' satisfaction of topical local anaesthesia in myringotomy and ventilation tube insertion.

J Laryngol Otol 2019 Apr 2:1-4. Epub 2019 Apr 2.

Department of ENT,East Kent Hospitals University NHS Foundation Trust, William Harvey Hospital,Ashford,UK.

Objectives: Animal studies have suggested that exposure of the middle ear to topical local anaesthesia may be ototoxic. This study aimed to report sensorineural hearing outcomes and patients' satisfaction in those who underwent myringotomy and ventilation tube insertion using topical local anaesthesia.

Methods: Twenty-nine patients (32 ears) were operated on. Read More

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http://dx.doi.org/10.1017/S0022215119000288DOI Listing

Ear- and hearing-related impact on quality of life in children with cleft palate: Development and pretest of a health-related quality of life (HRQOL) instrument.

Int J Pediatr Otorhinolaryngol 2019 Mar 20;122:35-39. Epub 2019 Mar 20.

Department of Head and Skin, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium.

Objectives: To investigate to what extent middle ear problems and associated hearing loss affect quality of life (QoL) of children born with a cleft palate.

Methods: Fifty-five children aged between 6 and 18 years, born with non-syndromic cleft palate ± cleft lip (CP/L) were included. A new health-related quality of life (HRQOL) questionnaire was generated with consideration of the following domains of QoL: communication, hearing loss, physical symptoms, limitation of activities and socio-emotional impact. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.03.023DOI Listing
March 2019
2 Reads

Challenges of Hearing Rehabilitation after Radiation and Chemotherapy.

J Neurol Surg B Skull Base 2019 Apr 4;80(2):214-224. Epub 2019 Feb 4.

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States.

Radiation and chemotherapy are frequently used in the treatment of head and neck malignancies. Ototoxicity is a common adverse effect of these treatment modalities. This article discusses the patterns of hearing loss following chemotherapy and radiation therapy. Read More

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http://dx.doi.org/10.1055/s-0039-1677865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438801PMC

The Pneumococcus and Its Critical Role in Public Health.

Methods Mol Biol 2019 ;1968:205-213

Paediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St. George's, University of London, London, UK.

Streptococcus pneumoniae is one of the commonest bacteria that cause morbidity and mortality in children and the elderly. The two extremes of age and individuals with underlying disease are particularly at risk of developing pneumococcal disease. The pneumococcus is responsible for a wide range of infectious diseases, ranging from mild, non-invasive infections such as otitis media and sinusitis, to more severe infections including pneumonia, septicemia, and meningitis. Read More

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http://dx.doi.org/10.1007/978-1-4939-9199-0_17DOI Listing
January 2019
4 Reads
2.100 Impact Factor

Control of bovine respiratory disease, with and without co-morbidity by otitis media, in dairy heifers comparing gamithromycin, tulathromycin, or no medication at a commercial development facility.

J Dairy Sci 2019 Mar 27. Epub 2019 Mar 27.

Private contractor, New Plymouth, ID 83655.

The objective of this study was to evaluate one strategy for control (metaphylaxis) of bovine respiratory disease, with and without co-morbidity with otitis media, in dairy heifers at a commercial development facility. Individual heifers were the experimental unit. At weaning, 1 of 3 experimental treatments (gamithromycin, tulathromycin, or no medication) was randomly assigned to 1,567 heifers from 11 different dairies. Read More

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http://dx.doi.org/10.3168/jds.2018-15809DOI Listing

Does The Type of Ossicular Chain Lesion Affect Outcomes in Chronic Suppurative Otitis Media Without Cholesteatoma?

J Int Adv Otol 2019 Mar 29. Epub 2019 Mar 29.

Department of Otorhinolaryngology - Head and Neck Surgery, Bajcsy-Zsilinszky Hospital, Budapest, Hungary.

Objectives: We evaluated the pattern of ossicular chain (OC) lesion in chronic suppurative otitis media (CSOM) without cholesteatoma and its impact on outcomes in primary and revision surgeries.

Materials And Methods: This was a retrospective chart review. Patients who underwent tympanoplasty due to CSOM with OC defect between 2010 and 2015 were included in the study. Read More

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http://dx.doi.org/10.5152/iao.2019.5554DOI Listing

Chronic Otitis Media with Granulation Is a Poor Prognostic Factor for Hearing Improvement and Development of Intracranial Complications.

J Int Adv Otol 2019 Mar 29. Epub 2019 Mar 29.

Department of Otolaryngology, Jagiellonian University School of Medicine, Krakow, Poland.

Objectives: Different types of chronic otitis media are distinguished based on the observed lesions in the middle ear mucous. Hearing improvement is a measurable effect of the surgical treatment of patients with chronic otitis media. Chronic cholesteatoma otitis media and chronic otitis media with inflammatory granulation have a tendency to damage the bone tissue, leading to the development of intratemporal and intracranial complications. Read More

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http://dx.doi.org/10.5152/iao.2019.4786DOI Listing

Analysis of factors associated with multiple ventilation tube insertions in children with otitis media with effusion.

J Laryngol Otol 2019 Mar 29:1-4. Epub 2019 Mar 29.

Department of Otolaryngology - Head and Neck Surgery,Daejeon St Mary's Hospital,College of Medicine,Catholic University of Korea,Daejeon,Korea.

Objective: To determine the factors related to multiple ventilation tube insertions in children with otitis media with effusion.

Methods: A retrospective review was performed of 126 ears of 81 children aged less than 12 years who had undergone insertion of a Paparella type 1 ventilation tube for the first time between August 2012 and March 2018.

Results: Mean age at the first operation was 4. Read More

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http://dx.doi.org/10.1017/S0022215119000495DOI Listing

Middle ear abnormalities at age 5 years in relation with early onset otitis media and number of episodes, in the Inuit population of Nunavik, Quebec, Canada.

Int J Circumpolar Health 2019 Dec;78(1):1599269

e Public Health Directorate , Nunavik Regional Board of Health and Social Services , Kuujjuaq , Canada.

Otitis media (OM) and their sequelae are a major health issue in the Inuit population of Nunavik, Quebec. Hypotheses of the study were: (i) early onset OM leads to repeated OM; (ii) repeated OM episodes leads to middle ear abnormalities (MEA) at age 5 years, (iii) pneumococcal conjugate vaccines (PCVs) may reduce multiple OM and MEA. Immunisation cards, medical records and audiology screening tests at age 5 years in a sample of 610 children born in 1994-2010 in 3 communities were reviewed. Read More

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http://dx.doi.org/10.1080/22423982.2019.1599269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442088PMC
December 2019

An overview on upper respiratory tract infections and bacteriotherapy as innovative therapeutic strategy.

Eur Rev Med Pharmacol Sci 2019 Mar;23(1 Suppl):27-38

Department of Medicine, Surgery and Neuroscience, ENT Clinic, University of Siena, Siena, Italy.

Objective: The aim of this review is to describe the most common recurring and chronic upper respiratory tract infections (URTI) in children and discuss the role of bacterial interference and bacteriotherapy in their prevention and treatment.

Materials And Methods: A literature review has been performed on the following topics: acute otitis media, adenoiditis, tonsillitis, rhinosinusitis, microbiotics and the role of bacterial interference, and bacteriotherapy in the prevention and treatment of URTI.

Results: Research studies into the characteristics of the microbiological flora and its role in the pathogenesis of URTI have focused on a single pathogen, on resistance to and ineffectiveness of antibiotic therapies, or on the persistence of bacterial biofilm. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17345DOI Listing
March 2019
1 Read

Correlation between otitis media with effusion and cranial deformation in children.

Eur Rev Med Pharmacol Sci 2019 Mar;23(1 Suppl):55-59

Department of Sense Organs, Sapienza University of Rome, Rome, Italy.

Objective: Otitis media with effusion (OME), defined as the presence of fluid in the ear without signs of an acute infection, usually occurs after acute otitis media and could result in reduced sound transmission with hearing loss. Several risk factors have been suggested to be associated with OME, as well as the relationships between morphology anomalies of cranial bones and ear infections. The aim of this study is to investigate the correlation between OME and cranial deformation in a pediatric population. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17350DOI Listing

The role of bacteriotherapy in the prevention of adenoidectomy.

Eur Rev Med Pharmacol Sci 2019 Mar;23(1 Suppl):44-47

Associazione Italiana Vie Aeree Superiori, Naples, Italy.

Objective: Adenoidectomy is a surgical procedure with potential adverse events. Effective nonsurgical therapy could reduce patient risk and harm. The aim of this study was to evaluate the role of bacteriotherapy to reduce the necessity of adenoid surgery. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17348DOI Listing

Diagnostic imaging in chronic otitis media: does CT and MRI fusion aid therapeutic decision making? - a pilot study.

Otolaryngol Pol 2018 Oct;73(1):1-5

Uniwersytet Medyczny w Łodzi Klinika Otolaryngologii i Laryngologii Onkologicznej I Katedra Otorynolaryngologii.

Introduction: Despite the recent advances in otosurgery diagnosis of cholesteatoma and qualification for surgery remains an issue in contemporary laryngology. In cases of cholesteatoma recidivism, it is of utmost importance to properly locate the pathology in the middle ear to plan surgical approach. Magnetic Resonance imaging in diffusion-weighted non-echoplanar sequences (non-EPI DWI) enables cholesteatoma detection as small as 2 mm and could potentially prevent unnecessary second-look surgery. Read More

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http://dx.doi.org/10.5604/01.3001.0012.5423DOI Listing
October 2018

Immunity-targeted approaches to the management of chronic and recurrent upper respiratory tract disorders in children.

Clin Otolaryngol 2019 Mar 28. Epub 2019 Mar 28.

Department of Otorhinolaryngology, National Institute of Pediatrics, Cuicuilco, Mexico.

Background/objective Of Review: Summarise the current evidence and address key questions concerning the use of conservative and immunity-targeted approaches to recurrent and chronic upper respiratory tract infections (URTIs), with a focus on the paediatric population.

Search Strategy/evaluation Method: Literature searches were conducted in March 2017 and updated in September 2017 using: Academic Search Complete; CENTRAL; Health Source: Nursing/Academic Edition; MEDLINE; clinicaltrials.gov and Cochrane databases. Read More

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http://dx.doi.org/10.1111/coa.13335DOI Listing
March 2019
2 Reads

Effect of vascular endothelial growth factor and its receptors in adult otitis media with effusion.

Eur Arch Otorhinolaryngol 2019 Mar 27. Epub 2019 Mar 27.

Department of Otolaryngology Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Beijing, 100029, People's Republic of China.

Purpose: Some studies have demonstrated that vascular endothelial growth factor (VEGF) plays a critical role in the pathogenesis of otitis media with effusion (OME) in animal models. However, the levels of VEGF and its receptors in adult OME have not been clarified. Our study was designed to detect the levels of VEGF and its receptors in adult OME and explore their relationship with effusion types, duration and prognosis of OME. Read More

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http://dx.doi.org/10.1007/s00405-019-05400-0DOI Listing

Use of delayed antibiotic prescription in primary care: a cross-sectional study.

BMC Fam Pract 2019 Mar 26;20(1):45. Epub 2019 Mar 26.

Iberoamerican Cochrane Center, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.

Background: One of several strategies developed to reduce inappropriate antibiotic use in situations where the indication is not clear is delayed antibiotic prescription (DAP), defined as an antibiotic prescription issued for the patient to take only in case of feeling worse or not feeling better several days after the visit. We conducted a survey to identify DAP use in Spanish primary care settings.

Methods: We surveyed 23 healthcare centers located in 4 autonomous regions where a randomized controlled trial (RCT) on DAP was underway. Read More

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http://dx.doi.org/10.1186/s12875-019-0934-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434640PMC
March 2019
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Endoscopic Type 1 Tympanoplasty in Chronic Otitis Media: Comparative Study with a Postauricular Microscopic Approach.

Otolaryngol Head Neck Surg 2019 Mar 26:194599819838778. Epub 2019 Mar 26.

1 Department of Otolaryngology, Saitama Medical Center, Saitama Medical University, Kawagoe-shi, Japan.

Objective: To compare surgical outcomes after tympanoplasty without ossiculoplasty for chronic otitis media between transcanal endoscopic ear surgery (TEES) and postauricular microscopic ear surgery (PAMES).

Study Design: Case-control study.

Setting: Tertiary care university hospital. Read More

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http://dx.doi.org/10.1177/0194599819838778DOI Listing

Delayed Diagnosis and Treatment of Cerebrospinal Fluid Leakage in Current Practice.

J Craniofac Surg 2019 Mar 20. Epub 2019 Mar 20.

Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

As delayed diagnosis and treatment of cerebrospinal fluid (CSF) leakage are common in current practice, this study was performed to determine associated factors and discuss appropriate strategies to deal with these problems. A retrospective analysis of all cases of CSF leakage in our hospital from 2007 to 2018, including 41 patients with CSF rhinorrhea and 5 with CSF otorhinorrhea, was performed. Symptoms, associated diseases, misdiagnoses, history of skull base repair surgical, previous medical costs, and number of hospital visits before visiting our institution were reviewed. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005402DOI Listing
March 2019
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Skull Base Mucormycosis in an Immunocompetent Patient: A Case Report and Literature Review.

Indian J Otolaryngol Head Neck Surg 2019 Mar 20;71(1):140-143. Epub 2018 Jun 20.

Department of ENT, Care Hospitals, Banjara Hills, Hyderabad, Telangana 500034 India.

To demonstrate the affection of skull base by mucormycosis in an immunocompetent individual. Mucormycosis is an opportunistic infection principally seen in immunocompromised individuals, but recently being increasingly recognized in otherwise healthy individuals. Skull base involvement secondary to otogenic nidus, mimicking otitis media was rarely reported. Read More

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http://dx.doi.org/10.1007/s12070-018-1428-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401032PMC

Correlation of Eustachian Tube Dysfunction with Results of Tympanoplasty in Mucosal Type of Chronic Suppurative Otitis Media.

Indian J Otolaryngol Head Neck Surg 2019 Mar 2;71(1):10-13. Epub 2018 Nov 2.

Gujarat Cancer Society Medical College and Research Institute, Ahmedabad, Gujarat India.

To Assess the relation between eustachian tube function and outcome of tympanoplasty in mucosal type of chronic suppurative otitis media, a prospective study was carried out over a period of one and half years (January 2016-July 2017) at a tertiary referral centre (Gujarat Cancer Society Medical College and Research Institute, Ahmedabad). Total 90 Patients of any age and sex and with Mucosal type of chronic suppurative otitis media and Patients with follow up of 12 months were selected. The Eustachian Tube function was assessed preoperatively by pressure swallow equalization test and impedance audiometry. Read More

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http://dx.doi.org/10.1007/s12070-018-1525-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401368PMC

A case of otitis externa caused by Schizophyllum commune: An approach to antimicrobial stewardship using Gram staining of otorrhea in a medical clinic.

J Infect Chemother 2019 Mar 21. Epub 2019 Mar 21.

Department of Clinical Laboratory Science, Faculty of Health Care, Tenri Health Care University, Tenri, Japan.

Recently, basidiomycete Schizophyllum commune has been reported as a cause of allergic bronchopulmonary mycosis. However, it is rare as a cause of otitis externa. We experienced a very rare case of otitis externa caused by S. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.03.005DOI Listing
March 2019
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Cleaved Cochlin Sequesters Pseudomonas aeruginosa and Activates Innate Immunity in the Inner Ear.

Cell Host Microbe 2019 Apr 21;25(4):513-525.e6. Epub 2019 Mar 21.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea; Airway Mucus Institute, Yonsei University College of Medicine, Seoul, South Korea. Electronic address:

In the inner ear, endolymph fluid surrounds the organ of Corti, which is important for auditory function; notably, even slight environmental changes mediated by trauma or infection can have significant consequences. However, it is unclear how the immune response is modulated in these tissues. Here, we report the local immune surveillance role of cleaved cochlin LCCL (Limulus factor C, Cochlin, and Lgl1) during Pseudomonas aeruginosa infection in the cochlea. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19313128193006
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http://dx.doi.org/10.1016/j.chom.2019.02.001DOI Listing
April 2019
2 Reads

Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model.

Dis Model Mech 2019 03 21;12(3). Epub 2019 Mar 21.

Developmental Biology Division, Roslin Institute and The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh EH25 9RG, UK

Auditory bulla cavitation defects are a cause of otitis media, but the normal cellular pattern of bulla mesenchyme regression and its failure are not well understood. In mice, neural-crest-derived mesenchyme occupies the bulla from embryonic day 17.5 (E17. Read More

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http://dx.doi.org/10.1242/dmm.038315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451434PMC
March 2019
3 Reads

Why do infants pull their ears?

Auris Nasus Larynx 2019 Mar 18. Epub 2019 Mar 18.

Kanuni Sultan Suleyman Training and Research Hospital Otolaryngolgy Clinic, Istanbul, Turkey.

Objective: In this study, we aimed to evaluate the diagnoses of the infants who were admitted to our outpatient clinic with the complaint of pulling on the ear and to identify the related factors which may contribute to the diagnosis.

Methods: This prospective study included a total of 102 infants who were admitted to our hospital with the complaint of tugging and pulling on, touching, and rubbing the ears on the shoulder or pillow and shaking the head between July 2016 and July 2017. The complaints were evaluated throughout the day, and the application seasons, the person referred the patient to the ear, nose, and throat (ENT) specialist, the child development specialist and child psychiatrist, allergy and atopy histories, and the relationship between the results and diagnoses were evaluated. Read More

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http://dx.doi.org/10.1016/j.anl.2019.02.009DOI Listing
March 2019
1 Read

Pneumocephalus and orbital emphysema associated with the use of an autoinflation device: a unique case report and review of the literature.

J Laryngol Otol 2019 Feb;133(2):157-160

Department of Otolaryngology,Ipswich Hospital,UK.

Background: Autoinflation devices are commonly used for otitis media with effusion and Eustachian tube dysfunction. Generally, these are very safe devices, with few or no complications.Case reportThis paper presents a case study of pneumocephalus and orbital emphysema, associated with the use of an autoinflation device, in a 73-year-old woman with Eustachian tube dysfunction and otitis media with effusion, and a history of extensive endoscopic sinus surgery 13 years previously. Read More

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http://dx.doi.org/10.1017/S0022215119000070DOI Listing
February 2019
4 Reads