3,309 results match your criteria Otitis Externa


Retrospective analysis of outcomes of outpatient parenteral antimicrobial therapy (OPAT) for necrotising otitis externa.

Eur J Clin Microbiol Infect Dis 2022 May 13. Epub 2022 May 13.

Laboratory of Biostatistics, School of Medicine, University of Crete, 71003, Heraklion, Greece.

Necrotising otitis externa (NOE) is an uncommon but life-threatening infection that requires prolonged systemic antimicrobial therapy. This study aims to identify factors associated with treatment response and outcome in patients with NOE treated through outpatient parenteral antimicrobial therapy (OPAT). We performed a retrospective analysis of patients with NOE treated over a 4-year period (January 2018-January 2022) at a tertiary referral hospital in Derbyshire, UK. Read More

View Article and Full-Text PDF

Facial Paralysis in Skull Base Osteomyelitis - Comparison of Surgical and Nonsurgical Management.

Laryngoscope 2022 May 12. Epub 2022 May 12.

The Otology Group, Department of Otolaryngology, Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Title: Facial Paralysis in Skull Base Osteomyelitis - Comparison of Surgical and Nonsurgical Management.

Objective: To compare outcomes of surgical and nonsurgical management in cases of facial paresis secondary to skull base osteomyelitis.

Methods: A 14 patients presenting with skull base osteomyelitis complicated by facial nerve paresis at a single tertiary referral center from 2009 to 2019 were retrospectively reviewed. Read More

View Article and Full-Text PDF

Modification of bacterial cell membrane dynamics and morphology upon exposure to sub inhibitory concentrations of ciprofloxacin.

Biochim Biophys Acta Biomembr 2022 Aug 21;1864(8):183935. Epub 2022 Apr 21.

Department of Physics, Indian Institute of Science, C.V. Raman Avenue, Bengaluru, 560012, Karnataka, India. Electronic address:

Ciprofloxacin (CPX), a second generation fluoroquinolone antibiotic, is used as a primary antibiotic for treatment against gastroenteritis, drug-resistant tuberculosis, and malignant otitis externa. CPX is a broad spectrum antibiotic that targets the DNA gyrase of both Gram-positive and Gram-negative bacteria. Irrational and improper usage of CPX results in emergence of CPX resistant organisms emphasizing the importance of using lethal doses of CPX. Read More

View Article and Full-Text PDF

A Cross-Sectional Study of Veterinarians in Germany on the Impact of the TÄHAV Amendment 2018 on Antimicrobial Use and Development of Antimicrobial Resistance in Dogs and Cats.

Antibiotics (Basel) 2022 Apr 5;11(4). Epub 2022 Apr 5.

Institute of Pharmacology and Toxicology, Department of Veterinary Medicine, Freie Universität Berlin, Koserstraße 20, 14195 Berlin, Germany.

To minimize the use of third- and fourth-generation cephalosporins and fluoroquinolones, the 2018 amendment to the regulations of veterinary pharmacies (TÄHAV) introduced legal restrictions in Germany. In an online survey among German veterinarians, we investigated the influence of these requirements on the use of antibiotics in the treatment of dogs and cats and the development of resistance rates. It was found that, on average, between 21% and 30% of daily treated dogs and cats received antimicrobial therapy. Read More

View Article and Full-Text PDF

Clinical and Microbiological Performances and Effects on Lipid and Cytokine Production of a Ceruminolytic Ear Cleaner in Canine Erythemato-Ceruminous Otitis Externa.

Vet Sci 2022 Apr 13;9(4). Epub 2022 Apr 13.

Department of Clinical Sciences, Université de Toulouse, ENVT, 31076 Toulouse, France.

Erythemato-ceruminous otitis externa (ECOE) is the most common type of otitis in dogs and is generally associated with bacterial and/or yeast infections. The performance of an ear cleaner was assessed over two weeks in canine ECOE, associated with a mild or moderate secondary infection, in a prospective open-label study. Forty ear canals with ECOE that did not receive any type of aural treatment and were not cleaned for 7 days were included. Read More

View Article and Full-Text PDF

Transcriptome Analysis of in Different Developmental Stages.

Front Microbiol 2022 4;13:687387. Epub 2022 Apr 4.

Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.

The mite is distributed worldwide and parasitism the ear canals of cats and dogs, causing otitis externa. Molecular biology of is poorly understood, with only a few genes being deposited in public databases. In the present study, we aimed to perform transcriptome analysis of using SMRT and Illumina sequencing of RNA from different development stages. Read More

View Article and Full-Text PDF

Otogenic Central Skull Base Osteomyelitis With Retropharyngeal Extension: A Case Report.

Cureus 2022 Mar 9;14(3):e22991. Epub 2022 Mar 9.

Otolaryngology, Hospital de Especialidades No. 2 Instituto Mexicano del Seguro Social (IMSS), Ciudad Obregón, MEX.

Skull base osteomyelitis (SBO) is a life-threatening condition in patients with underlying comorbidities. Ear infections may spread through normal skull base fissures in this group of patients. However, its diagnosis is frequently delayed due to the unspecific clinical findings at onset, such as headache, with diverse cranial neuropathies later as the disease progresses. Read More

View Article and Full-Text PDF

Diagnostic approach to patients at risk of otogenic skull base osteomyelitis.

Acta Otolaryngol 2022 Apr 6:1-8. Epub 2022 Apr 6.

Department of Otolaryngology, The Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.

Background: Otogenic skull base osteomyelitis (OSBO) is rare and potentially fatal sequelae of otitis externa. Accurate and timely diagnosis is important due to rising incidence, morbidity and costs associated with treatment. Consensus on the diagnostic approach for OSBO has yet to be reached, in particular the utility of imaging modalities. Read More

View Article and Full-Text PDF

Association of comorbidities and medications with risk of asthma exacerbation in pediatric patients: a retrospective study using Japanese claims data.

Sci Rep 2022 04 1;12(1):5509. Epub 2022 Apr 1.

Teikyo University Graduate School of Public Health, 2-11-1 Kaga Itabashi-ku, Tokyo, 173-8605, Japan.

Asthma exacerbation impairs the quality of life of pediatric patients and negatively impacts future respiratory function and health economics. Several risk factors associated with exacerbations have been identified; however, most studies report the risk of each factor. Therefore, this study aimed to evaluate the risk of each factor and a combination of factors. Read More

View Article and Full-Text PDF

.

Comp Med 2022 Apr 28;72(2):104-112. Epub 2022 Mar 28.

Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.

Otitis externa (OE) is a condition that involves inflammation of the external ear canal. OE is a commonly reported condition in humans and some veterinary species (for example, dogs, cats), but has not been reported in the literature in macaques. Here, we present a case series of acute and chronic OE likely precipitated by abrasion of the ear canal with a tympanic membrane electrode in 7 adult male rhesus macaques (). Read More

View Article and Full-Text PDF

Patient Experience of Necrotising Otitis Externa: A Qualitative Study.

J Laryngol Otol 2022 Mar 28:1-33. Epub 2022 Mar 28.

Manchester University NHS Foundation Trust.

View Article and Full-Text PDF

Antifungal susceptibility of isolated from the external auditive conduct from dogs, in central Chile.

Open Vet J 2022 Jan-Feb;12(1):99-104. Epub 2022 Feb 10.

Escuela de Medicina Veterinaria, Facultad de Recursos Naturales y Medicina Veterinaria, Universidad Santo Tomás, Talca, Chile.

Background: External otitis is common in dogs, and one of the main agents involved is , a yeast belonging to the otic microbiota. Empirical treatment can fail; therefore, it is essential to know the antifungal susceptibility profile to prescribe appropriate treatment, a fact scarcely reported in Chile.

Aim: This study aimed to determine the antifungal sensitivity of isolated from the external auditory canal of dogs in central Chile. Read More

View Article and Full-Text PDF

Necrotising otitis externa: a serious condition becoming more frequently encountered.

J Laryngol Otol 2021 Nov 25:1-5. Epub 2021 Nov 25.

ENT Department, Barking Havering and Redbridge University Hospitals, London, UK.

Background: Necrotising otitis externa is an aggressive infection of the external ear, which extends to the surrounding bone and soft tissue. In recent years, there has been an apparent increase in the number of patients admitted to our hospital with this condition.

Methods: A retrospective review was conducted of all patients admitted to our hospital with necrotising otitis externa between July 2012 and June 2020. Read More

View Article and Full-Text PDF
November 2021

Laboratory and imaging findings of necrotizing otitis externa are associated with pathogen type and disease outcome: A retrospective analysis.

Ear Nose Throat J 2022 Mar 19:1455613221080973. Epub 2022 Mar 19.

Department of Otolaryngology Head and Neck Surgery, 37255Lady Davis Carmel Medical Center, and the Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.

Objective: To examine associations of laboratory and imaging data with diagnostic parameters of necrotizing otitis externa (NOE) and its severity, and to compare between bacterial and fungal infections.

Methods: Records of patients diagnosed with NOE during 2010-2018 at the Department of Otolaryngology, Head and Neck Surgery were reviewed retrospectively for demographics; disease characteristics; and laboratory, scintigraphy, and imaging results.

Results: Of 48 patients with NOE, the mean age is 73±11. Read More

View Article and Full-Text PDF

Utility of Temporal Bone Computed Tomography in Pediatric Emergency Medicine.

West J Emerg Med 2022 Feb 9;23(2):238-245. Epub 2022 Feb 9.

The Pennsylvania State University, College of Medicine, Department of Otolaryngology - Head and Neck Surgery, Hershey, Pennsylvania.

Objective: Temporal bone computed tomography (CT) requires a relatively high radiation dose to produce high-resolution images required to define surgical anatomy. In the acute setting, the need for this detailed evaluation of temporal bone pathology may not be required for nonsurgical management and clinical decision-making. We performed a retrospective review of the clinical characteristics and subsequent management of children who underwent CT of the temporal bone with the goal of optimizing clinical decision-making and mitigating the risks of radiation exposure in children. Read More

View Article and Full-Text PDF
February 2022

Brachycephaly in French bulldogs and pugs is associated with narrow ear canals.

Vet Dermatol 2022 Jun 16;33(3):214-e60. Epub 2022 Mar 16.

Small Animal Department, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany.

Background: Brachycephalic dog breeds have multiple skull malformations which may lead to anatomical changes in the external auditory canal. It is our frequent observation that in the otoscopic examination of the external ear in these breeds we are unable to visualise the tympanic membrane as a consequence of extreme narrowing of the proximal ear canal. Additionally brachycephalic dogs reportedly are predisposed to otitis externa (OE) and otitis media. Read More

View Article and Full-Text PDF

Multiplex Cytokine Analyses in Ear Canals of Dogs Suggest Involvement of IL-8 Chemokine in Atopic Otitis and Otodectic Mange-Preliminary Results.

Animals (Basel) 2022 Feb 25;12(5). Epub 2022 Feb 25.

Department of Clinical Sciences, Université de Toulouse, ENVT, 31076 Toulouse, France.

Cutaneous cytokines and chemokines are involved in the pathogenesis of human and canine atopic dermatitis. The aim of the present study was to discriminate cytokine expression in the ear canals of atopic dogs with otitis, dogs with non-allergic inflammatory otitis (otodectic mange) and healthy non-atopic dogs. The ear canals of nine atopic dogs suffering from non-infected otitis externa ( = 14 ears), 10 healthy dogs suffering from otodectic mange ( = 20 ears) and 21 healthy controls (39 ears) were swabbed. Read More

View Article and Full-Text PDF
February 2022

The use of a caudal auricular axial pattern flap for repair of a degloving pinna wound in a dog.

Can Vet J 2022 Mar;63(3):275-280

Cornell University College of Veterinary Medicine, Department of Clinical Sciences, Ithaca, New York, USA.

A 3-year-old male neutered French bulldog was presented for an anatomical degloving injury of the left pinna following a conflict with a larger dog at a park. Approximately 2/3 of the dorsal skin was removed from the convex surface of the left pinna along with an irregular, full thickness injury on the lateral aspect of the pinna distal to the cutaneous marginal pouch. A caudal auricular axial pattern flap (CAAPF) was used to reconstruct the pinna. Read More

View Article and Full-Text PDF

Malignant otitis externa presenting cerebral infarction from pseudoaneurysm: A case report and a review of the literature.

Clin Case Rep 2022 Feb 14;10(2):e05276. Epub 2022 Feb 14.

Department of Otolaryngology, Head and Neck Surgery Tohoku University School of Medicine Sendai Japan.

Chronic renal failure and diabetes mellitus could also be risk factors of pseudoaneurysm of the internal carotid artery (ICA) due to malignant otitis externa (MOE). Although pseudoaneurysm of the ICA is a rarely encountered disease, it should always be taken into consideration when treating patients of MOE. Read More

View Article and Full-Text PDF
February 2022

Chronic otitis externa with heat shock protein 70-positive intranuclear inclusion bodies in the ceruminous gland epithelium of a Chihuahua dog.

J Toxicol Pathol 2022 Jan 28;35(1):83-87. Epub 2021 Aug 28.

Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro-shi, Hokkaido 080-8555, Japan.

A Chihuahua dog showed persistent itching in the right ear canal. Anti-inflammatory medicines and prednisolone were ineffective and total ear canal ablation was performed. Histological diagnosis was chronic otitis externa. Read More

View Article and Full-Text PDF
January 2022

Necrotising otitis externa antibiotic therapy complications: A retrospective cohort analysis.

Clin Otolaryngol 2022 May 1;47(3):491-494. Epub 2022 Mar 1.

Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, UK.

View Article and Full-Text PDF

A Different Era for Malignant Otitis Externa: The Non-Diabetic and Non-Immunocompromised Patients.

J Int Adv Otol 2022 Jan;18(1):20-24

2nd Otolaryngology Department, National and Kapodistrian University of Athens Faculty of Medicine, "Attikon" University Hospital, Athens, Greece.

Background: Τo investigate the differences in regard to the clinical, laboratory, and imaging findings as well as the treatment course between diabetic and non-diabetic, non-immunocompromised patients with malignant otitis externa.

Methods: A total of 36 hospitalized patients diagnosed with malignant otitis externa between January 2011 and December 2020 were divided into 2 groups according to their medical history, blood glucose, and glycated hemoglobin levels.

Results: Thirty-two patients were diabetic (group A) and 4 were non-diabetic, non-immunocompromised (group B). Read More

View Article and Full-Text PDF
January 2022

High rates of multidrug resistance in bacteria associated with small animal otitis: A study of cumulative microbiological culture and antimicrobial susceptibility.

Microb Pathog 2022 Apr 16;165:105399. Epub 2022 Feb 16.

Laboratory of Veterinary Microbiology and Immunology, Instituto Federal Farroupilha, Frederico, Westphalen, RS, Brazil. Electronic address:

The etiology of otitis in dogs and cats is multifactorial and complex, involving bacterial and fungal pathogens. As empiric antimicrobial prescription is a common practice when treating such cases, antimicrobial resistance may represent a complicating factor. The aim of this study was to describe microbiological features and susceptibility profiles of pathogens associated with 142 cases of external otitis, comprising 138 dogs and 4 cats. Read More

View Article and Full-Text PDF

A bis(pyrazolyl)methane derivative against clinical strains isolated from otitis externa.

Laryngoscope Investig Otolaryngol 2022 Feb 18;7(1):283-290. Epub 2022 Jan 18.

Instituto de Investigación en Discapacidades Neurológicas (IDINE) University of Castilla-La Mancha Albacete Spain.

Objective: The purpose of this study was to evaluate the in vitro antibacterial effects of a Cymene-based bis(pyrazolyl)methane derivative (SC-19) to advance in developing alternative therapeutic compounds to fight against bacterial isolates from patients with otitis externa (OE).

Methods: Eighteen swab specimens were collected from patients aged over 18 years diagnosed with OE within at least 7 days of symptom onset, contaminated by only one bacterium type: ( = 5); ( = 8); ( = 2); ( = 1); ( = 2). To appraise antibacterial activity, minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), minimum biofilm inhibitory concentration (MBIC), and minimum biofilm eradication concentration (MBEC) assays were run at different SC-19 concentrations. Read More

View Article and Full-Text PDF
February 2022

Comparison of the clinical outcome of endoscopic push-through myringoplasty and microscopic overlay myringoplasty: matching co-variated designs.

BMC Surg 2022 Feb 11;22(1):44. Epub 2022 Feb 11.

Skull Base Surgery Unit, Department of Otorhinolaryngology, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, 40002.

Background: The conventional microscopic overlayer myringoplasty is preferred because it allows a both hands technique, not reducing middle ear space, increasing the blood supply in the repaired area, and providing graft support; however, this technique may be troublesome for the novice surgeon during tympanomeatal flap elevation. Recently, the endoscopic push-through myringoplasty technique has developed. It provides better visualization of the hidden areas and does not require raising tympanomeatal flap. Read More

View Article and Full-Text PDF
February 2022

Sertaconazole versus Clotrimazole and Miconazole Creams in the Treatment of Otomycosis: A Placebo-Controlled Clinical Trial.

Iran J Otorhinolaryngol 2022 Jan;34(120):27-34

Otorhinolaryngology Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Introduction: Fungal otitis extern or otomycosis, is common worldwide, and resistance of fungal organisms to antifungal drugs has been reported in otomycosis and other fungal infections. This study aimed to evaluate the clinical efficacy of sertaconazole versus placebo, as well as miconazole and clotrimazole topical creams in otomycosis patients.

Materials And Methods: In this double-blinded clinical trial, 138 otomycosis patients (230 ears) were evaluated in four groups. Read More

View Article and Full-Text PDF
January 2022

Prevalence of Infectious Diseases Among 6078 Individuals With Down Syndrome in the United States.

J Patient Cent Res Rev 2022 17;9(1):64-69. Epub 2022 Jan 17.

Advocate Aurora Health, Downers Grove, IL.

A recent disease prevalence study of the largest documented Down syndrome (DS) cohort in the United States strongly suggested significant disparity in general infectious disease conditions among individuals with DS versus those without DS. In this follow-up retrospective analysis, we explored these differences in greater detail by calculating prevalence of 52 infectious diseases, across 28 years of data among 6078 individuals with DS and 30,326 age- and sex-matched controls, abstracted from electronic medical records within a large Midwestern health system. We found that the DS cohort had higher prevalence of pneumonias (including aspiration, viral, bacterial, pneumococcal, and unspecified/atypical); otitis externa; and the skin infections impetigo, abscess, and cellulitis. Read More

View Article and Full-Text PDF
January 2022