34,204 results match your criteria Osteosarcoma


MiR-16-1-3p and miR-16-2-3p possess strong tumor suppressive and anti-metastatic properties in osteosarcoma.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-IMRIC, The Hebrew University-Hadassah Medical School at Ein-Kerem, Jerusalem, Israel.

Osteosarcoma (OS) is an aggressive malignancy affecting mostly children and adolescents. MicroRNAs (miRNAs) play important roles in OS development and progression. Here we found that miR-16-1-3p and miR-16-2-3p "passenger" strands as well as the "lead" miR-16-5p strand are frequently downregulated and possess strong tumor suppressive functions in human OS. Read More

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http://dx.doi.org/10.1002/ijc.32368DOI Listing

miR-628-5p promotes the growth and migration of osteosarcoma by targeting IFI44L.

Biochem Cell Biol 2019 Apr 24. Epub 2019 Apr 24.

The First Hospital of China Medical University, Shenyang, China ;

This study investigated the role of miR-628-5p and interferon-induced protein 44-like (IFI44L) in osteosarcoma (OS) and determined whether miR-628-5p modulated OS growth by regulating IFI44L. Based on the data downloaded from Gene Expression Omnibus (GEO) database, we revealed that the expression of IFI44L was down-regulated in OS and low expression of IFI44L was correlated with better prognosis of patients with OS. Biological prediction of its upstream regulatory miRNAs on the miRWalk website found that miR-628-5p is a possible upstream regulatory miRNA of IFI44L. Read More

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http://dx.doi.org/10.1139/bcb-2019-0001DOI Listing

Sarcoma Stem Cell Heterogeneity.

Adv Exp Med Biol 2019 ;1123:95-118

Central University Hospital of Asturias-Health Research Institute of Asturias, Oviedo, Spain.

Sarcomas represent an extensive group of divergent malignant diseases, with the only common characteristic of being derived from mesenchymal cells. As such, sarcomas are by definition very heterogeneous, and this heterogeneity does not manifest only upon intertumoral comparison on a bulk tumor level but can be extended to intratumoral level. Whereas part of this intratumoral heterogeneity could be understood in terms of clonal genetic evolution, an essential part includes a hierarchical relationship between sarcoma cells, governed by both genetic and epigenetic influences, signals that sarcoma cells are exposed to, and intrinsic developmental programs derived from sarcoma cells of origin. Read More

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http://dx.doi.org/10.1007/978-3-030-11096-3_7DOI Listing
January 2019

Inhibition of CaMKIIα Activity Enhances Antitumor Effect of Fullerene C60 Nanocrystals by Suppression of Autophagic Degradation.

Adv Sci (Weinh) 2019 Apr 10;6(8):1801233. Epub 2019 Feb 10.

Department of Orthopedics Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai Bone Tumor Institution 100 Haining Street Shanghai 200080 P. R. China.

Fullerene C60 nanocrystals (nano-C60) possess various attractive bioactivities, including autophagy induction and calcium/calmodulin-dependent protein kinase IIα (CaMKIIα) activation. CaMKIIα is a multifunctional protein kinase involved in many cellular processes including tumor progression; however, the biological effects of CaMKIIα activity modulated by nano-C60 in tumors have not been reported, and the relationship between CaMKIIα activity and autophagic degradation remains unclear. Herein, nano-C60 is demonstrated to elicit reactive oxygen species (ROS)-dependent cytotoxicity and persistent activation of CaMKIIα in osteosarcoma (OS) cells. Read More

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http://dx.doi.org/10.1002/advs.201801233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468974PMC

Remote imaging of single cell 3D morphology with ultrafast coherent phonons and their resonance harmonics.

Sci Rep 2019 Apr 23;9(1):6409. Epub 2019 Apr 23.

University of Bordeaux, CNRS UMR 5295, I2M, F-33400, Talence, France.

Cell morphological analysis has long been used in cell biology and physiology for abnormality identification, early cancer detection, and dynamic change analysis under specific environmental stresses. This work reports on the remote mapping of cell 3D morphology with an in-plane resolution limited by optics and an out-of-plane accuracy down to a tenth of the optical wavelength. For this, GHz coherent acoustic phonons and their resonance harmonics were tracked by means of an ultrafast opto-acoustic technique. Read More

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http://dx.doi.org/10.1038/s41598-019-42718-5DOI Listing

MiR-19a as a prognostic indicator for cancer patients: a meta-analysis.

Biosci Rep 2019 Apr 23. Epub 2019 Apr 23.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

MiR-19a was aberrantly expressed in various types of cancers and was observed to be potentially associated with the prognosis of cancer patients. The present analysis aims to elucidate its precise predictive value in various human malignancies. Online electronic searches of PubMed, Web of Science (WOS), Embase in English and VIP, Wanfang, SinoMed and the China National Knowledge Infrastructure (CNKI) in Chinese up to September 8, 2018 were conducted. Read More

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http://dx.doi.org/10.1042/BSR20182370DOI Listing

Transcriptional regulation of voltage-gated sodium channels contributes to GM-CSF induced pain.

J Neurosci 2019 Apr 23. Epub 2019 Apr 23.

Department of Pharmacology, Hebei Medical University; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, China; The Key Laboratory of New Drug Pharmacology and Toxicology, Hebei Province; Shijiazhuang, China.

Granulocyte-macrophage colony stimulating factor (GM-CSF) induces production of granulocyte and macrophage populations from the hematopoietic progenitor cells; it is one of the most common growth factors in the blood. GM-CSF is also involved in bone cancer pain development by regulating tumor-nerve interactions, remodeling of peripheral nerves and sensitization of damage-sensing (nociceptive) nerves. However, the precise mechanism for GM-CSF-dependent pain is unclear. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.2204-18.2019DOI Listing

Positron Emission Tomography Detects In Vivo Expression of Disialoganglioside GD2 in Mouse Models of Primary and Metastatic Osteosarcoma.

Cancer Res 2019 Apr 23. Epub 2019 Apr 23.

Diagnostic Imaging, St. Jude Children's Research Hospital

The cell membrane glycolipid GD2 is expressed by multiple solid tumors, including 88% of osteosarcomas and 98% of neuroblastomas. However, osteosarcomas are highly heterogeneous with many tumors exhibiting GD2 expression on <50% of the individual cells while some tumors are essentially GD2-negative. Anti-GD2 immunotherapy is the current standard of care for high-risk neuroblastoma, but its application to recurrent osteosarcomas, for which no effective therapies exist, has been extremely limited. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3340DOI Listing

Osteosarcoma after the age of fifty: A clinicopathological study.

Eur J Surg Oncol 2019 Apr 13. Epub 2019 Apr 13.

Service d'orthopédie, Hôpital Cochin, AP-HP, Paris, France, Université Paris Descartes, Paris, France.

Introduction: Osteosarcoma, a primary malignant bone tumor, has a well-recognised double peak of incidence in early adolescence and after 50 years. This study investigates the clinical features and prognostic factors of patients older than 50 years with osteosarcoma.

Materiel And Methods: From January 2000 to December 2012, in one bone tumor reference center, 32 patients aged more than 50 years at the diagnosis (mean age: 62. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.04.010DOI Listing

[Clinical efficacy and safety of apatinib combined with chemotherapy for osteosarcoma and soft tissue sarcoma with pulmonary metastasis].

Zhonghua Zhong Liu Za Zhi 2019 Apr;41(4):309-314

Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China.

To compare the clinical efficacy and drug safety between oral apatinib combined with conventional chemotherapy and conventional chemotherapy alone for the treatment of osteosarcoma and soft tissue sarcoma patients with pulmonary metastasis. Thirty-three osteosarcoma and soft tissue sarcoma patients with pulmonary metastasis who were treated in the Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University from January 2015 to December 2017 were enrolled in this study. Patients with osteosarcoma received methotrexate, adriamycin (ADM), cisplatin (CDDP), ifosfamide (IFO) sequential regimen; patients with soft tissue sarcoma were treated with IFO and ADM regimen. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.04.012DOI Listing

Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling.

Int J Mol Sci 2019 Apr 12;20(8). Epub 2019 Apr 12.

Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Montebello, 0379 Oslo, Norway.

Mitogen-activated protein kinases (MAPK): Erk1 and Erk2 are key players in negative-feedback regulation of fibroblast growth factor (FGF) signaling. Upon activation, Erk1 and Erk2 directly phosphorylate FGF receptor 1 (FGFR1) at a specific serine residue in the C-terminal part of the receptor, substantially reducing the tyrosine phosphorylation in the receptor kinase domain and its signaling. Similarly, active Erks can also phosphorylate multiple threonine residues in the docking protein FGF receptor substrate 2 (FRS2), a major mediator of FGFR signaling. Read More

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http://dx.doi.org/10.3390/ijms20081826DOI Listing

Randomized Double-Blind Phase II Study of Regorafenib in Patients With Metastatic Osteosarcoma.

J Clin Oncol 2019 Apr 23:JCO1802374. Epub 2019 Apr 23.

16 Monter Cancer Center, Northwell Health, Lake Success, NY, and Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.

Purpose: SARC024 is a phase II clinical trial of the multikinase inhibitor regorafenib in specific sarcoma subtypes, including advanced osteosarcoma. We hypothesized that regorafenib would improve progression-free survival (PFS) in patients with sarcoma and report the results of the osteosarcoma cohort.

Patients And Methods: This trial enrolled patients with progressive metastatic osteosarcoma with measurable disease by RECIST who had received at least one prior line of therapy. Read More

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http://dx.doi.org/10.1200/JCO.18.02374DOI Listing

Evaluation of sleep quality in adolescent patients with osteosarcoma using Pittsburgh Sleep Quality Index.

Eur J Cancer Care (Engl) 2019 Apr 23:e13065. Epub 2019 Apr 23.

Department of Orthopedic Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.

The sleep quality of patients with osteosarcoma (OS) was poorly understood. We aimed to evaluate the prevalence of sleep dysfunction in adolescent patients with OS using the Pittsburgh Sleep Quality Index (PSQI) and to further investigate the psychometric properties of the PSQI in this cohort of patients. Fifty four adolescent patients with OS who underwent chemotherapy treatment in our clinic centre were included. Read More

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http://dx.doi.org/10.1111/ecc.13065DOI Listing

Curative-intent radiotherapy for pediatric osteosarcoma: The St. Jude experience.

Pediatr Blood Cancer 2019 Apr 22:e27763. Epub 2019 Apr 22.

Departments of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Background: Radiation therapy (RT) confers local tumor control and survival advantages in some patients with osteosarcoma, yet pediatric and adolescent and young adult (AYA) population studies are limited.

Methods: Twenty-eight patients treated with curative-intent RT (median dose, 59.4 Gy; range, 40-76 Gy) at our institution from 1990 to 2017 were retrospectively identified. Read More

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http://dx.doi.org/10.1002/pbc.27763DOI Listing

Survival analysis of elderly patients with osteosarcoma.

Int Orthop 2019 Apr 22. Epub 2019 Apr 22.

Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: Few studies have described the characteristics and prognostic factors of elderly patients with osteosarcoma. We retrospectively investigated clinico-pathological features and prognostic factors in osteosarcoma patients > 40 years old.

Methods: Patients with high-grade osteosarcoma > 40 years old who were treated at our institutions from 2000 to 2016 were recruited for this study. Read More

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http://dx.doi.org/10.1007/s00264-019-04332-yDOI Listing

Role of autophagy in osteosarcoma.

J Bone Oncol 2019 Jun 3;16:100235. Epub 2019 Apr 3.

UMR E-4320 TIRO-MATOs CEA/DRF/BIAM, Faculté de Médecine Nice, Université Nice Sophia Antipolis, Avenue de Valombrose, 06107 Nice Cédex 2, France.

Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents. It is a highly aggressive tumor with a tendency to spread to the lungs, which are the most common site of metastasis. Advanced osteosarcoma patients with metastasis share a poor prognosis. Read More

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http://dx.doi.org/10.1016/j.jbo.2019.100235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460301PMC

Long noncoding RNA UCA1 promotes osteosarcoma metastasis through CREB1-mediated epithelial-mesenchymal transition and activating PI3K/AKT/mTOR pathway.

J Bone Oncol 2019 Jun 1;16:100228. Epub 2019 Mar 1.

Department of Orthopedics, No. 215 Hospital of Shannxi Nuclear Industry, Xianyang, Shaanxi 712000, PR China.

Increasing evidences have demonstrated that Long noncoding RNAs (lncRNAs) are key regulatory RNAs that participate in multiple biological processes. LncRNA urothelial carcinoma-associated 1 () is a newly identified lncRNA and functions as a regulator of growth in several cancers. However, the biological function and molecular mechanism of in the metastasis of osteosarcoma remain unclear. Read More

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http://dx.doi.org/10.1016/j.jbo.2019.100228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463206PMC

Lupeol suppresses migration and invasion via p38/MAPK and PI3K/Akt signaling pathways in human osteosarcoma U-2 OS cells.

Biosci Biotechnol Biochem 2019 Apr 22:1-11. Epub 2019 Apr 22.

a Department of Biological Science and Technology , China Medical University , Taichung , Taiwan.

Lupeol, one of the common components from the fruits and natural foods, has been reported to exert antitumor activities in many human cancer cell lines; however, its effects on osteosarcoma cell metastasis were not elucidated. In the present study, lupeol at 10-25 μM induced cell morphological changes and decreased total viable cell number in U-2 OS cells. Lupeol (5-15 μM) suppressed cell mobility, migration, and invasion by wound healing and transwell chamber assays, respectively. Read More

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http://dx.doi.org/10.1080/09168451.2019.1606693DOI Listing

Late-onset osteosarcoma after onychectomy in a cat.

JFMS Open Rep 2019 Jan-Jun;5(1):2055116919842394. Epub 2019 Apr 9.

South Austin Cat Hospital, Austin, TX 78747, USA.

Case Summary: A 12-year-old neutered male onychectomized Ragdoll cat presented for a 3 day history of swelling and hemorrhagic purulent discharge on the first digit of the left manus. Radiographs revealed fragments of the third phalangeal bone (P3) present in the partially amputated digits with swelling adjacent to the P3 fragment on the first digit of the left manus. Thoracic radiographs revealed no evidence of primary or metastatic neoplasia. Read More

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http://dx.doi.org/10.1177/2055116919842394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457030PMC

Knocking down miR-384 promotes growth and metastasis of osteosarcoma MG63 cells by targeting SLBP.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1458-1465

b Department of Radiology , China-Japan Union Hospital of Jilin University , Changchun , China.

Osteosarcoma is a common malignant bone tumour in adolescents and old people, with highly invasive and metastatic features and poor prognosis. This study aimed to explore the role of miR-384 in osteosarcoma MG63 cells by targeting SLBP. Cell viability, migration and invasion, apoptosis, as well as apoptosis-related factors were evaluated by CCK-8 assay, Transwell assay, flow cytometer and Western blotting, respectively. Read More

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https://www.tandfonline.com/doi/full/10.1080/21691401.2019.1
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http://dx.doi.org/10.1080/21691401.2019.1601099DOI Listing
December 2019
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Ossified Mandibular Mass: Osteosarcoma.

Authors:
Galal Omami

Ear Nose Throat J 2019 Apr 22:145561319845608. Epub 2019 Apr 22.

1 Division of Oral Medicine, Diagnosis and Radiology, Department of Oral Health Practice, University of Kentucky College of Dentistry, Lexington, KY, USA.

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http://dx.doi.org/10.1177/0145561319845608DOI Listing

A comparison of risk factors for metastasis at diagnosis in humans and dogs with osteosarcoma.

Cancer Med 2019 Apr 21. Epub 2019 Apr 21.

Division of Pediatric Epidemiology and Clinical Research, School of Medicine, University of Minnesota, Minneapolis, Minnesota.

Background: Canine osteosarcoma (OS) is a relevant spontaneous model for human OS. Identifying similarities in clinical characteristics associated with metastasis at diagnosis in both species may substantiate research aimed at using canine OS as a model for identifying mechanisms driving distant spread in the human disease.

Methods: This retrospective study included dog OS cases from three academic veterinary hospitals and human OS cases from the Surveillance, Epidemiology, and End Results program. Read More

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http://dx.doi.org/10.1002/cam4.2177DOI Listing

Establishment of three-dimensional canine osteosarcoma cell lines showing vasculogenic mimicry and evaluation of biological properties after treatment with 17-AAG.

Vet Comp Oncol 2019 Apr 21. Epub 2019 Apr 21.

Faculty of Veterinary Medicine, University of Teramo, Teramo (TE), Italy.

Vasculogenic mimicry (VM) is an alternative type of blood perfusion characterized by formation of non-endothelial cell-lined microcirculatory channels and is responsible for aggressive tumor biology and increased tumor-related mortality. VM-correlated genes are associated with vascular endothelial grown factor receptor 1 (VEGFR1), and hypoxia-related (hypoxia inducible factor 1 α - HIF1α) signaling pathways, whose molecules are client proteins of Hsp90 (Heat shock protein 90) and are potential therapeutic targets. This pilot study was aimed to investigate vasculogenic mimicry in a three-dimensional (3D) cell culture system of two aggressive canine osteosarcoma (OSA) cell lines (D22 and D17), and to evaluate the response of these cells to 17-AAG treatment in relation to tubular-like structure formation in vitro. Read More

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http://dx.doi.org/10.1111/vco.12482DOI Listing

miR-1285-3p is a potential prognostic marker in human osteosarcoma and functions as a tumor suppressor by targeting YAP1.

Cancer Biomark 2019 Apr 8. Epub 2019 Apr 8.

Background: Despite the major advances in the treatment, the overall survival of osteosarcoma remains poor. MicroRNAs (miRNAs) are involved in tumorigenesis and progression though modulating their target genes. In the present study, the roles of miR-1285-3p in osteosarcoma was investigated. Read More

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http://dx.doi.org/10.3233/CBM-180013DOI Listing
April 2019
1 Read

Craniomaxillofacial osteosarcoma - The role of surgical margins.

J Craniomaxillofac Surg 2019 Mar 25. Epub 2019 Mar 25.

Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland; Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Research Programme in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. Electronic address:

Background: Osteosarcomas (OS) in the craniomaxillofacial (CMF) region are typically diagnosed at later age than long-bone OS, but they are reported to have better 5-year survival. Curative treatment warrants wide surgical resection, which is often not possible in the CMF region. The purpose of this article is to present a nationwide series of CMF in Finland to discuss the role of surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10105182183113
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http://dx.doi.org/10.1016/j.jcms.2019.03.020DOI Listing
March 2019
1 Read

High-resolution large-area imaging of nanoscale structure and mineralization of a sclerosing osteosarcoma in human bone.

J Struct Biol 2019 Apr 17. Epub 2019 Apr 17.

Department of Material Sciences and Process Engineering, University of Natural Resources and Life Sciences, Vienna, Austria.

Osteosarcoma is the most common primary bone cancer type in humans. It is predominantly found in young individuals, with a second peak later in life. The tumour is formed by malignant osteoblasts and consists of collagenous, sometimes also mineralized, bone matrix. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10478477193007
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http://dx.doi.org/10.1016/j.jsb.2019.04.012DOI Listing
April 2019
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cPLAa correlates with metastasis and poor prognosis of osteosarcoma by facilitating epithelial-mesenchymal transition.

Pathol Res Pract 2019 Mar 27. Epub 2019 Mar 27.

Department of Orthopedics, The Affiliated Hospital of Putian University, Putian, Fujian, China. Electronic address:

Background: Osteosarcoma (OS) patients with metastasis have very dismal prognoses, and lack effective target therapies. Overexpression of cytosolic phospholipase A2 (cPLA) has been shown to promote progression in several types of cancers, but its functions in OS have not been investigated.

Materials And Methods: In our study, the expression of cPLAa was detected with immunohistochemistry in 102 cases of OS. Read More

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http://dx.doi.org/10.1016/j.prp.2019.03.026DOI Listing

The Endocannabinoid/Endovanilloid System in Bone: From Osteoporosis to Osteosarcoma.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

Department of Women, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.

Bone is a dynamic tissue, whose homeostasis is maintained by a fine balance between osteoclast (OC) and osteoblast (OB) activity. The endocannabinoid/endovanilloid (EC/EV) system's receptors are the cannabinoid receptor type 1 (CB1), the cannabinoid receptor type 2 (CB2), and the transient receptor potential cation channel subfamily V member 1 (TRPV1). Their stimulation modulates bone formation and bone resorption. Read More

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https://www.mdpi.com/1422-0067/20/8/1919
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http://dx.doi.org/10.3390/ijms20081919DOI Listing
April 2019
3 Reads

MicroRNA-Based Diagnosis and Treatment of Metastatic Human Osteosarcoma.

Cancers (Basel) 2019 Apr 18;11(4). Epub 2019 Apr 18.

Division of Pathological Biochemistry, Tottori University Faculty of Medicine, Yonago, Tottori 683-8503, Japan.

Osteosarcoma is a malignant tumor of the bones that commonly occurs in young individuals. The 5-year survival rate of osteosarcoma patients is 60-70%. Metastasis to the lungs leads to death in 30-40% of osteosarcoma patients. Read More

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https://www.mdpi.com/2072-6694/11/4/553
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http://dx.doi.org/10.3390/cancers11040553DOI Listing
April 2019
2 Reads

Long noncoding RNA AFAP1-AS1 promoted osteosarcoma proliferation and invasion via upregulating BDNF.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2744-2749

Department of Orthopaedic Surgery, The No. 1 People's Hospital of Jingzhou, Jingzhou, China.

Objective: Recently, long noncoding RNAs (lncRNAs) have got much attention for their role in tumor progression. LncRNA AFAP1-AS1 was studied in this research to identify how it affects the development and proliferation of osteosarcoma.

Patients And Methods: The mRNA expression of AFAP1-AS1 in osteosarcoma cells and tissue samples was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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http://www.europeanreview.org/article/17547
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http://dx.doi.org/10.26355/eurrev_201904_17547DOI Listing
April 2019
1 Read

Nimotuzuma restrains proliferation and induces apoptosis in human osteosarcoma cells by regulation of EGFR/PI3K/AKT signal pathway.

J Cell Physiol 2019 Apr 18. Epub 2019 Apr 18.

Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.

Osteosarcoma (OS) is a conversant malignant bone tumor, commonly occurs in children and adolescents. Nimotuzuma is an epidermal growth factor receptor (EGRF) monoclonal antibody agent, which has been exploited in varied solid tumors. Nevertheless, the functions of Nimotuzuma in OS remain blurry. Read More

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http://dx.doi.org/10.1002/jcp.28693DOI Listing

Targeting Tumor Vascular CD99 Inhibits Tumor Growth.

Front Immunol 2019 2;10:651. Epub 2019 Apr 2.

Angiogenesis Laboratory, Department of Medical Oncology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam UMC, Amsterdam, Netherlands.

CD99 (MIC2; single-chain type-1 glycoprotein) is a heavily O-glycosylated transmembrane protein (32 kDa) present on leukocytes and activated endothelium. Expression of CD99 on endothelium is important in lymphocyte diapedesis. CD99 is a diagnostic marker for Ewing's Sarcoma (EWS), as it is highly expressed by these tumors. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00651
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http://dx.doi.org/10.3389/fimmu.2019.00651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455290PMC
April 2019
1 Read

Overexpression of FER1L4 promotes the apoptosis and suppresses epithelial-mesenchymal transition and stemness markers via activating PI3K/AKT signaling pathway in osteosarcoma cells.

Pathol Res Pract 2019 Apr 6. Epub 2019 Apr 6.

Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, 100050, PR China.

Novel long non-coding RNA Fer-1-like protein 4 (FER1L4) has been identified as a tumor suppressor in endometrial carcinoma, ovarian cancer, hepatocellular carcinoma, esophageal squamous cell carcinoma. However, the function of FER1L4 in osteosarcoma has not been clear. The aim of the research was to explore the effects of FER1L4 in osteosarcoma. Read More

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http://dx.doi.org/10.1016/j.prp.2019.04.004DOI Listing

Up-regulation of microRNA-496 suppresses proliferation, invasion, migration and in vivo tumorigenicity of human osteosarcoma cells by targeting eIF4E.

Biochimie 2019 Apr 15. Epub 2019 Apr 15.

The Second Department of Orthopedics, The Fifth Hospital of Harbin, Harbin, 150040, Heilongjiang Province, PR China. Electronic address:

Osteosarcoma is an aggressive bone tumor characterized by a high level of genetic instability and recurring DNA deletions and amplifications. This study aims to investigate how microRNA-496 (miR-496) affects proliferation, invasion, and migration of human osteosarcoma (OS) cells and in vivo tumorigenicity by targeting eukaryotic translation initiation factor 4E (eIF4E). Microarray-based gene expression profiling involving OS was used in order to identify differentially expressed genes. Read More

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http://dx.doi.org/10.1016/j.biochi.2019.04.017DOI Listing

α,γ-Diketocarboxylic Acids and Their Esters Act as Carbonic Anhydrase IX and XII Selective Inhibitors.

ACS Med Chem Lett 2019 Apr 19;10(4):661-665. Epub 2019 Feb 19.

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy.

Among human carbonic anhydrase (CA) inhibitors, the α,γ-diketocarboxylic acids and esters are still poorly investigated. Here, we report the first compounds of this class (-) acting as potent inhibitors at low nanomolar level against the cancer-related human CA IX and XII, and 2-3 magnitude orders selective toward the cytosolic isoforms hCA I and II. At enzymatic level, the α,γ-diketoacids - were more effective inhibitors compared to the corresponding ethyl esters -. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.9b00023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466837PMC

STIM1 expression is associated with osteosarcoma cell survival.

Chin J Cancer Res 2019 Feb;31(1):203-211

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA.

Objective: To examine the role of store-operated calcium entry (SOCE) and stromal interaction molecule 1 (STIM1) in survival and migration of osteosarcoma cells and investigate what blockade of store-operated Ca contributes to the regulation of osteosarcoma cells.

Methods: First, we examined the expression levels of STIM1 in osteosarcoma cell lines by Western analysis and in tissue specimens by immunohistochemistry. Second, we investigated the effect of SOCE and STIM1 on osteosarcoma cell viability using MTS assays and on cell proliferation using colony formation. Read More

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http://article.cjcrcn.org/en/article/doi/10.21147/j.issn.100
Publisher Site
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.01.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433589PMC
February 2019
1 Read

[Rasfonin inhibits proliferation and migration of osteosarcoma 143B cells].

Authors:
F Zhang T Q Yan W Guo

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):234-238

Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing 100044, China.

Objective: To investigate the effects of rasfonin, a fungal secondary metabolite, on the proliferation and migration of osteosarcoma 143B cells.

Methods: 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) assay was performed to examine 143B cell viability following treatment of rasfonin. Using dimethyl sulfoxide (DMSO) group as control, cell viability was detected when 143B cells were treated with rasfonin (3 μmol/L and 6 μmol/L) for 12 or 24 hours. Read More

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April 2019
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Anti-CD166/4-1BB chimeric antigen receptor T cell therapy for the treatment of osteosarcoma.

J Exp Clin Cancer Res 2019 Apr 17;38(1):168. Epub 2019 Apr 17.

Department of Orthopedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, #88 Jie Fang Road, Hangzhou, 310009, Zhejiang, People's Republic of China.

Background: Chimeric antigen receptor (CAR)-engineered T cells have displayed outstanding performance in the treatment of patients with hematological malignancies. However, their efficacy against solid tumors has been largely limited.

Methods: In this study, human osteosarcoma cell lines were prepared, flow cytometry using antibodies against CD166 was performed on different cell samples. Read More

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https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-
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http://dx.doi.org/10.1186/s13046-019-1147-6DOI Listing
April 2019
2 Reads

EP1 receptor is involved in prostaglandin E2-induced osteosarcoma growth.

Bosn J Basic Med Sci 2019 Apr 18. Epub 2019 Apr 18.

Department of Hand and Foot Surgery, The Second Hospital Affiliated to Soochow University, Suzhou; Department of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei Anhui, China.

Recent studies showed that the activation of prostaglandin (PG) receptor EP1 promotes cell migration and invasion in different cancers. The aim of this study was to investigate the role of EP1 in the proliferation of osteosarcoma (OS) cells in vitro and in vivo. EP1 mRNA and protein levels were analyzed by real-time RT-PCR and Western blot, respectively in human OS cell lines MG63, OS732, U-2OS, HOS and SAOS-2 compared to human fetal osteoblastic hFOB 1. Read More

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http://www.bjbms.org/ojs/index.php/bjbms/article/view/4177
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http://dx.doi.org/10.17305/bjbms.2019.4177DOI Listing
April 2019
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Viable and necrotic tumor assessment from whole slide images of osteosarcoma using machine-learning and deep-learning models.

PLoS One 2019 17;14(4):e0210706. Epub 2019 Apr 17.

The University of Texas Southwestern Medical Center, Dallas, TX, United States of America.

Pathological estimation of tumor necrosis after chemotherapy is essential for patients with osteosarcoma. This study reports the first fully automated tool to assess viable and necrotic tumor in osteosarcoma, employing advances in histopathology digitization and automated learning. We selected 40 digitized whole slide images representing the heterogeneity of osteosarcoma and chemotherapy response. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210706PLOS

Monitoring Response to Neoadjuvant Chemotherapy of Primary Osteosarcoma Using Diffusion Kurtosis Magnetic Resonance Imaging: Initial Findings.

Korean J Radiol 2019 May;20(5):801-811

Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Objective: To determine whether diffusion kurtosis imaging (DKI) is effective in monitoring tumor response to neoadjuvant chemotherapy in patients with osteosarcoma.

Materials And Methods: Twenty-nine osteosarcoma patients (20 men and 9 women; mean age, 17.6 ± 7. Read More

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http://dx.doi.org/10.3348/kjr.2018.0453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470081PMC

Sarcomas of the mandible.

J Surg Oncol 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York.

Introduction: Sarcomas of the mandible are extremely rare tumors, with osteosarcoma being the most common, followed by Ewing's sarcoma MATERIALS AND METHODS: A retrospective review of the clinical records, imaging studies, and pathology slides of patients with sarcoma of the mandible at a Tertiary Care Cancer Center from 1998 to 2014 was undertaken. The impact of neoadjuvant chemotherapy and postoperative radiotherapy with or without chemotherapy was studied, and factors impacting upon local control and disease-specific survival were analyzed.

Results: Twenty-two patients were treated over the study period, comprising of 15 males and seven females. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jso.25477
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http://dx.doi.org/10.1002/jso.25477DOI Listing
April 2019
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Potential Regulatory Effects of miR-182-3p in Osteosarcoma via Targeting EBF2.

Biomed Res Int 2019 12;2019:4897905. Epub 2019 Mar 12.

Department of Orthopedics, the Second Hospital of Jilin University, Ziqiang Street 218, Changchun, Jilin 130041, China.

Osteosarcoma (OS) is one of the most common primary malignant bone tumors in adolescents with a high mortality rate. MicroRNA (miRNA) is a kind of noncoding RNAs and has been proved to participate in many physiological processes. Many miRNAs have been reported to act as function regulators in OS. Read More

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https://www.hindawi.com/journals/bmri/2019/4897905/
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http://dx.doi.org/10.1155/2019/4897905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434304PMC
March 2019
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p27/Kip1 functions as a tumor suppressor and oncoprotein in osteosarcoma.

Sci Rep 2019 Apr 16;9(1):6161. Epub 2019 Apr 16.

Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, 19803, USA.

The p27/kip1 (p27) tumor suppressor inhibits cyclin/cyclin-dependent kinase (CDK) complexes and halts cell cycle progression. p27 further regulates invasion and migration in cancer cells, suggesting p27 also functions as an oncoprotein. Using a human osteosarcoma tissue microarray we identified high expression of cytoplasmic p27 in metastatic tumors. Read More

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http://dx.doi.org/10.1038/s41598-019-42450-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467888PMC

ROCK Inhibition Induces Terminal Adipocyte Differentiation and Suppresses Tumorigenesis in Chemoresistant Osteosarcoma Cells.

Cancer Res 2019 Apr 16. Epub 2019 Apr 16.

Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine

Tumors comprise heterogeneous cell types including cancer stem cells (CSC), progenitor cells, and differentiated cells. Chemoresistance is a potential cause of relapse and a key characteristic of CSC, but the development of novel therapeutic approaches for targeting these cells has been limited. We previously established osteosarcoma-initiating (OSi) cells by introducing the gene for c-Myc into bone marrow stromal cells of Ink4a/Arf knockout mice. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2693DOI Listing

Genome sequencing analysis of blood cells identifies germline haplotypes strongly associated with drug resistance in osteosarcoma patients.

BMC Cancer 2019 Apr 16;19(1):357. Epub 2019 Apr 16.

Inova Children's Hospital, Falls Church, VA, USA.

Background: Osteosarcoma is the most common malignant bone tumor in children. Survival remains poor among histologically poor responders, and there is a need to identify them at diagnosis to avoid delivering ineffective therapy. Genetic variation contributes to a wide range of response and toxicity related to chemotherapy. Read More

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http://dx.doi.org/10.1186/s12885-019-5474-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466653PMC
April 2019
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Prognosis of Primary Osteosarcoma in Elderly Patients: A Comparison between Young and Elderly Patients.

Med Princ Pract 2019 Apr 17. Epub 2019 Apr 17.

Objectives: Osteosarcoma is the most common malignant bone tumor in childhood. Although a poorer prognosis has been described in older patients, few reports have focused solely on primary osteosarcoma. We evaluated the clinical features of elderly patients with primary osteosarcoma. Read More

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http://dx.doi.org/10.1159/000500404DOI Listing
April 2019
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Increased Risk of Lung Metastases in Patients with Giant Cell Bone Tumors: A Systematic Review.

Authors:
Josef Yayan

Adv Exp Med Biol 2019 Apr 16. Epub 2019 Apr 16.

Department of Internal Medicine, Division of Pulmonary, Allergy and Sleep Medicine, HELIOS Clinic Wuppertal, Witten/Herdecke University, Witten, Germany.

Giant cell tumors of the bone are rare, usually benign, tumors consisting of large, multinucleated bone cells. Remarkably, these tumors are characterized by aggressive growth. They tend to recur frequently and, in rare cases, metastasize to the lungs. Read More

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http://dx.doi.org/10.1007/5584_2019_372DOI Listing
April 2019
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