36,393 results match your criteria Osteosarcoma


Design and evaluation a kind of functional biomaterial for bone tissue engineering: Selenium/mesoporous bioactive glass nanospheres.

J Colloid Interface Sci 2020 Jul 1;579:654-666. Epub 2020 Jul 1.

College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China. Electronic address:

Conventional treatments of bone tumor involve removal followed by radiation and chemotherapeutic drugs that may have limitations and cause secondary damage. The development of functional filling biomaterial has led to a new strategy for tumor therapy. In this study, a novel therapeutic ion selenium doped mesoporous bioactive glasses (Se/MBG) nanospheres were successfully synthesized by a facile sol-gel technique using cetyl trimethyl ammonium bromide (CTAB) as the template, which had uniform spherical morphology (≈ 400 nm), high surface area (>400 m/g) and mesopore volume (≈0. Read More

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http://dx.doi.org/10.1016/j.jcis.2020.06.122DOI Listing

Controlled Release of Soy Isoflavones from 3D Printed Bone Scaffolds for Bone Tissue Engineering.

Acta Biomater 2020 Jul 8. Epub 2020 Jul 8.

W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington 99164, United States. Electronic address:

Recent challenges in post-surgical bone tumor management have elucidated the need for a multifunctional scaffold, which can be used for residual tumor-cell suppression, defect repair, and simultaneous bone regeneration. In this perspective, 3D printing allows to create a wide variety of patient-specific implant with complex porous architecture and compatible mechanical strength to that of cancellous bone. Here, a multifunctional bone graft substitute is designed by incorporating the three primary soy isoflavones: genistein, daidzein, and glycitein onto a 3D printed (3DP) tricalcium phosphate (TCP) scaffolds with designed pores, endowing them with in vitro chemopreventive, bone-cell proliferating and immune-modulatory potential. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.07.006DOI Listing

Autologous cancer cell vaccination, adoptive T-cell transfer, and interleukin-2 administration results in long-term survival for companion dogs with osteosarcoma.

J Vet Intern Med 2020 Jul 10. Epub 2020 Jul 10.

Elias Animal Health, Olathe, Kansas, USA.

Background: Osteosarcoma (OSA) in dogs is an aggressive bone tumor with frequent chemotherapy failure and translational relevance for human health.

Hypothesis/objectives: We hypothesized that dogs with OSA could be treated safely by ex vivo activated T-cells that were generated by autologous cancer vaccination and supported by interleukin-2 (IL-2) treatment with survival more than twice that reported for amputation alone.

Animals: Osteosarcoma-bearing dogs (n = 14) were enrolled in a single-arm prospective trial after complete staging before amputation. Read More

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http://dx.doi.org/10.1111/jvim.15852DOI Listing

A Bioprinted In Vitro Model for Osteoblast to Osteocyte Transformation by Changing Mechanical Properties of the ECM.

Adv Biosyst 2019 Oct 21;3(10):e1900126. Epub 2019 Aug 21.

School of Biomedical Engineering, McMaster University, 1280 Main Street West, L8S 4L7, Hamilton, Ontario, Canada.

Osteocytes are key contributors to bone remodeling. During the remodeling process, trapped osteoblasts undergo a phenotypic change to become osteocytes. The specific mechanisms by which osteocytes work are still debatable and models that exist to study them are sparse. Read More

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http://dx.doi.org/10.1002/adbi.201900126DOI Listing
October 2019

Image based cellular contractile force evaluation with small-world network inspired CNN: SW-UNet.

Biochem Biophys Res Commun 2020 Jul 6. Epub 2020 Jul 6.

Division of Bioengineering, Graduate School of Engineering Science, Osaka University, Japan, 1-3 Machikaneyama Toyonaka, Osaka, 5608531, Japan. Electronic address:

We propose an image based cellular contractile force evaluation method using a machine learning technique. We use a special substrate that exhibits wrinkles when cells grab the substrate and contract, and the wrinkles can be used to visualize the force magnitude and direction. In order to extract wrinkles from the microscope images, we develop a new CNN (convolutional neural network) architecture SW-UNet (small-world U-Net), which is a CNN that reflects the concept of the small-world network. Read More

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http://dx.doi.org/10.1016/j.bbrc.2020.04.134DOI Listing

Is increased symptom interval associated with advanced stage and poorer outcome? A prospective multicenter study of 220 patients with osteosarcoma around the knee.

Cancer Epidemiol 2020 Jul 6;67:101776. Epub 2020 Jul 6.

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Objective: Osteosarcoma is rare disease and there is a strong controversy about the potential impact of symptom interval on the stage of disease and patients' outcomes. We want to assess whether increased symptom interval (SI) is associated with advanced tumor stage and poor prognosis for patients with osteosarcoma.

Methods: We analyzed prospectively collected data of 220 patients younger than 40 years who had osteosarcoma around the knee. Read More

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http://dx.doi.org/10.1016/j.canep.2020.101776DOI Listing

MicroRNA-532-5p is a prognostic marker and inhibits the aggressive phenotypes of osteosarcoma through targeting CXCL2.

Kaohsiung J Med Sci 2020 Jul 9. Epub 2020 Jul 9.

Orthopeadic Surgery, The Third People's Hospital of Qingdao, Qingdao, Shandong, China.

The dysregulation of miR-532-5p is involved in the development of several cancers. Nevertheless, the roles of miR-532-5p in osteosarcoma (OS) have yet to be illuminated. In the present study, we found that miR-532-5p was significantly downregulated in both OS tissues and cell lines. Read More

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http://dx.doi.org/10.1002/kjm2.12261DOI Listing

A Phase 1 and pharmacokinetic study evaluating daily or weekly schedules of the humanized anti-GD2 antibody hu14.18K322A in recurrent/refractory solid tumors.

MAbs 2020 Jan-Dec;12(1):1773751

Department of Oncology, St. Jude Children's Research Hospital , Memphis, TN, USA.

Hu14.18K322A is a humanized anti-GD2 monoclonal antibody with a single point mutation that reduces complement-mediated cytotoxicity, with a maximum tolerated dose (MTD) of 60 mg/m daily for 4 days in children with recurrent/refractory neuroblastoma. We report additional results of a Phase 1 trial to determine the MTD and safety profile of hu14. Read More

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http://dx.doi.org/10.1080/19420862.2020.1773751DOI Listing

Diagnostic Challenges in Chondroblastic Maxillary Osteosarcoma: A Case Report.

Cureus 2020 Jun 2;12(6):e8418. Epub 2020 Jun 2.

Pathology, King Faisal Specialist Hospital and Research Center, Jeddah, SAU.

The diagnosis of craniofacial osteosarcoma can be quite challenging, and the condition often goes unrecognized for a considerable period of time. In this report, we discuss the case of a 21-year old woman who presented with a one-year history of a small swelling over the left maxillary alveolar ridge. Upon further investigation, the histopathological examination showed high-grade chondroblastic osteosarcoma. Read More

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http://dx.doi.org/10.7759/cureus.8418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336646PMC

Radical change in osteosarcoma surgical plan due to COVID-19 pandemic.

BMJ Case Rep 2020 Jul 8;13(7). Epub 2020 Jul 8.

Department of Orthopedics, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.

A 17-year-old man with osteosarcoma of the proximal humerus was planned for possible limb salvage surgery after standard neoadjuvant chemotherapy. However, during the surgical phase of treatment, the COVID-19 or SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) outbreak occurred changing the healthcare landscape due to uncertainty regarding the virus, risk of COVID-19 infection and complications, and implementation of an enhanced community quarantine restricting movement of people within cities. Instead of limb salvage surgery, the patient underwent a forequarter amputation. Read More

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http://dx.doi.org/10.1136/bcr-2020-237197DOI Listing

Head and neck sarcomas in adulthood: current trends and evolving management concepts.

Br J Oral Maxillofac Surg 2020 Jul 4. Epub 2020 Jul 4.

University College Hospital London, 250 Euston Road, London NW1 2PG, United Kingdom. Electronic address:

Sarcomas are rare, malignant bone and soft-tissue tumours of mesenchymal origin, and their overall incidence accounts for 1% and 0.2%, respectively, of all malignancies. The aim of this article is to provide a reference on the evolving management concepts and trends of treatment of adult sarcomas of the head and neck in a major head and neck sarcoma centre. Read More

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http://dx.doi.org/10.1016/j.bjoms.2020.05.015DOI Listing

Bone-targeting Prodrug Mesoporous Silica-Based Nanoreactor with Reactive Oxygen Species Burst for Enhanced Chemotherapy.

ACS Appl Mater Interfaces 2020 Jul 8. Epub 2020 Jul 8.

Cancer remains a primary threat to human lives. Recently amplification of tumor associated reactive oxygen species (ROS) has been used as a boosting strategy to improve tumor therapy. Here we report on a bone targeting prodrug mesoporous silica-based nanoreactor for combined photodynamic therapy (PDT) and enhanced chemotherapy for osteosarcoma. Read More

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http://dx.doi.org/10.1021/acsami.0c08992DOI Listing

The Sp1/FOXC1/HOTTIP/LATS2/YAP/β-catenin cascade promotes malignant and metastatic progression of osteosarcoma.

Mol Oncol 2020 Jul 7. Epub 2020 Jul 7.

Department of Orthopaedics, The 2nd Xiangya Hospital, Central South University, Changsha, 410011, P.R. China.

The prognosis for osteosarcoma (OS) is dismal due to the aggressive tumor growth and high incidence of metastasis. The long non-coding RNA human homeobox A transcript at the distal tip (HOTTIP) and the transcription factor Forkhead box C1 (FOXC1) present oncogenic activities in OS. Here, we aimed at gaining insights into the underlying mechanisms and their crosstalk. Read More

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http://dx.doi.org/10.1002/1878-0261.12760DOI Listing

Co-delivery of doxorubicin and paclitaxel by reduction/pH dual responsive nanocarriers for osteosarcoma therapy.

Drug Deliv 2020 Dec;27(1):1044-1053

Department of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, P. R. China.

Nanoparticle-based drug delivery system offers a promising platform for combination cancer therapy. However, the inefficient drug release in cells reduces the therapeutic efficacy of cancer nanomedicines. Herein, a PEGylated poly(α-lipoic acid) copolymer (mPEG-PαLA) was prepared and used as a reduction/pH dual responsive nanocarrier to simultaneously deliver paclitaxel (PTX) and doxorubicin (DOX) for osteosarcoma therapy. Read More

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http://dx.doi.org/10.1080/10717544.2020.1785049DOI Listing
December 2020

LncRNA DANCR regulates osteosarcoma migration and invasion by targeting miR-149/MSI2 axis.

Eur Rev Med Pharmacol Sci 2020 Jun;24(12):6551-6560

Department of Oncology, the Third Affiliated Hospital of Qiqihar Medical College, Qiqihar, Heilongjaing, P.R. China.

Objective: As a new LncRNA, anti-differentiated non-coding RNA (DANCR) plays an important role in tumorigenesis and development, and its molecular mechanism in osteosarcoma is unclear. In this study, by investigating osteosarcoma tissue and cells, we explored the molecular mechanism by which lncRNA DANCR regulates the occurrence and development of osteosarcoma by targeting the miR-149 / MSI2 axis.

Patients And Methods: In this study, osteosarcoma tissues and adjacent tissues in 109 patients were collected, and the relative expression of DANCR was detected by qPCR. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21639DOI Listing

Circ100284 promotes invasion and migration of osteosarcoma cells by down-regulating PTEN and EMP1.

Authors:
Y-D Liu L-P Liu

Eur Rev Med Pharmacol Sci 2020 Jun;24(12):6540-6550

Department of Osteoarthrosurgery, Jining No. 1 People's Hospital, Jining, China.

Objective: To investigate the role of circ100284 in osteosarcoma (OS) and the underlying mechanism.

Patients And Methods: Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was used to detect the level of circ100284 in OS tissues and cells, and to examine the association between its level and clinicopathological features such as tumor size, tumor stage, and survival time. In addition, circ100284 was knocked out in MG63 and U2OS cells to observe the effect of circ100284 on cell viability, migration, cycle, and apoptosis by Cell Counting Kit-8 (CCK-8), transwell assay, and flow cytometry assay. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21638DOI Listing

Knockdown of ZEB2-AS1 inhibits cell proliferation, invasion and induces apoptosis in osteosarcoma by combining with EZH2.

Eur Rev Med Pharmacol Sci 2020 Jun;24(12):6533-6539

Department of Orthopedics, Shuyang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Suqian, China.

Objective: This study aims to explore whether ZEB2-AS1 can promote the development of osteosarcoma by affecting the proliferation, invasion, and apoptosis of osteosarcoma cells.

Patients And Methods: Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was performed to detect the ZEB2-AS1 expression in osteosarcoma tissue specimens and normal bone tissues. After ZEB2-AS1 downregulation, Cell Counting Kit-8 (CCK-8) test, plate cloning assay, 5-Ethynyl-2'-deoxyuridine (EdU) experiment, and flow cytometry were conducted to analyze the changes in cell proliferation and apoptosis. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21637DOI Listing

MiR-663a, regulated by lncRNA GAS5, contributes to osteosarcoma development through targeting MYL9.

Authors:
S Zhao W Xiong K Xu

Hum Exp Toxicol 2020 Jul 7:960327120937330. Epub 2020 Jul 7.

Department of Orthopaedics, Ningbo Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China.

Osteosarcoma is characterized by high malignancy and high metastasis rate, resulting in high mortality and disability. MiR-663a has been reported in a variety of tumors to promote tumorigenesis. However, miR-663a has not been reported in the pathogenesis of osteosarcoma. Read More

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http://dx.doi.org/10.1177/0960327120937330DOI Listing

Guideline for Limb-Salvage Treatment of Osteosarcoma.

Orthop Surg 2020 Jul 6. Epub 2020 Jul 6.

Department of Bone Oncology, Tianjin hospital, Tianjin, China.

Osteosarcoma is the most common primary malignant bone tumor, occurring mainly in children and adolescents, and the limbs are the main affected sites. At present, limb-salvage treatment is considered as an effective basic standard treatment for osteosarcoma of the limb. China has a vast territory, but the development of technology is not balanced,which requires sufficient theoretical coverage, strong technical guidance and the application of limb-salvage treatment guidelines to the treatment of osteosarcoma. Read More

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http://dx.doi.org/10.1111/os.12702DOI Listing

Stearoyl-CoA Desaturase-1 Attenuates the High Shear Force Damage Effect on Human MG63 Osteosarcoma Cells.

Int J Mol Sci 2020 Jul 2;21(13). Epub 2020 Jul 2.

Department of Orthopaedics and Traumatology, Veterans General Hospital, Taipei 112, Taiwan.

Mechanical regulation is known as an important regulator in cancer progression and malignancy. High shear force has been found to inhibit the cell cycle progression and result in cell death in various cancer cells. Stearoyl-CoA desaturase (SCD)-1, one of the important lipogenic enzymes, has recently been indicated as a potential pharmaceutical target in cancer therapy. Read More

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http://dx.doi.org/10.3390/ijms21134720DOI Listing

Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact.

Int J Mol Sci 2020 Jun 30;21(13). Epub 2020 Jun 30.

IRCCS Istituto Ortopedico Rizzoli, Laboratory of Experimental Oncology, Pharmacogenomics and Pharmacogenetics Research Unit, Bologna, Italy.

High-grade osteosarcoma (HGOS) is a very aggressive bone tumor which primarily affects adolescents and young adults. Although not advanced as is the case for other cancers, pharmacogenetic and pharmacogenomic studies applied to HGOS have been providing hope for an improved understanding of the biology and the identification of genetic biomarkers, which may impact on clinical care management. Recent developments of pharmacogenetics and pharmacogenomics in HGOS are expected to: i) highlight genetic events that trigger oncogenesis or which may act as drivers of disease; ii) validate research models that best predict clinical behavior; and iii) indicate genetic biomarkers associated with clinical outcome (in terms of treatment response, survival probability and susceptibility to chemotherapy-related toxicities). Read More

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http://dx.doi.org/10.3390/ijms21134659DOI Listing

MiRNA-206 suppresses the metastasis of osteosarcoma via targeting Notch3.

J Biol Regul Homeost Agents 2020 May-Jun;34(3):775-783

Department of Spinal surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.

To investigate the role of microRNA-206 (miRNA-206) in the malignant progression of osteosarcoma and the underlying mechanism, expression pattern of miRNA-206 in osteosarcoma tissues and cell lines was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Correlation between miRNA-206 level and prognosis of osteosarcoma patients was analyzed. Regulatory effects of miRNA-206 on the proliferation and metastasis of U2OS and MG63 cells were evaluated by cell counting kit-8 (CCK-8), Transwell and wound healing assay. Read More

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http://dx.doi.org/10.23812/20-72-A-26DOI Listing

Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.

Oncol Rep 2020 Jul 12;44(1):103-114. Epub 2020 May 12.

Department of Orthopedics, Guizhou Provincial Orthopedics Hospital, Guiyang, Guizhou 550000, P.R. China.

Keratins are fibrous structural proteins that serve essential roles in forming the stratum corneum and protect the cells in this layer of skin from damage. Keratin 17 (KRT17) is a key member of the keratins, and dysregulated expression of KRT17 has been reported in various types of cancer, such as lung and gastric cancer. The present study aimed to identify the role of KRT17 in osteosarcoma and the underlying molecular mechanism. Read More

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http://dx.doi.org/10.3892/or.2020.7611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251737PMC

Mitochondrial APE1 promotes cisplatin resistance by downregulating ROS in osteosarcoma.

Oncol Rep 2020 Aug 4;44(2):499-508. Epub 2020 Jun 4.

Cancer Center, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, P.R. China.

Apurinic/apyrimidinic endonuclease 1 (APE1) is a primary nuclear‑localized multifunctional protein in osteosarcoma. However, the cytoplasmic localization of APE1 was found to be functional and to increase with cisplatin resistance, yet the molecular mechanism is unknown. In the present study, we explored the cisplatin resistance mechanism in osteosarcoma from the new perspective of APE1 extranuclear biological activity. Read More

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http://dx.doi.org/10.3892/or.2020.7633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336412PMC

Cadmium chloride enhances cisplatin sensitivity in osteosarcoma cells by reducing FOXM1 expression.

Oncol Rep 2020 Aug 4;44(2):650-660. Epub 2020 Jun 4.

Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China.

Osteosarcoma is a highly malignant disease and is associated with a poor patient prognosis and a high mortality rate. Disease prognosis significantly correlates with chemotherapeutic responses. Cadmium is a heavy metal with specific effects on bone, but its benefits for osteosarcoma treatment have not been characterized. Read More

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http://dx.doi.org/10.3892/or.2020.7632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336512PMC

Bisphosphonates in common pediatric and adult bone sarcomas.

Bone 2020 Jul 2:115523. Epub 2020 Jul 2.

Institut de Cancérologie de l'Ouest, Saint-Herblain, France; Université de Nantes, Institut de Cancérologie de l'Ouest, Saint-Herblain, France; University of Sheffield, Dept of Oncology and Metabolism, School of Medicine, Sheffield, UK.

The therapeutic strategies proposed currently for bone sarcomas are based on neo-adjuvant chemotherapy, delayed en-bloc wide resection, and adjuvant chemotherapy. Unfortunately, bone sarcomas are characterized by high rates of poor drug response, with a high risk of drug resistance, local recurrence and/or a high propensity for induced metastases. The pathogenesis of bone sarcomas is strongly associated with dysregulation of local bone remodeling and increased osteolysis that plays a part in tumor development. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115523DOI Listing

Magnetic targeting cobalt nanowire-based multifunctional therapeutic system for anticancer treatment and angiogenesis.

Colloids Surf B Biointerfaces 2020 Jun 27;194:111217. Epub 2020 Jun 27.

School of Chemical Engineering, Sichuan University, Chengdu 610065, China; State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China. Electronic address:

In order to improve the anticancer therapeutic efficacy and postoperative recovery efficacy, the novel anticancer therapeutic system should have the ability to promote angiogenesis after anticancer therapy besides the excellent anticancer therapeutic efficacy. We present herein a magnetic targeting multifunctional anticancer therapeutic system based on cobalt nanowires (CoNWs) for anticancer therapy and angiogenesis. Magnetic characterization shows that the CoNWs can be concentrated in desired locations under the external magnetic field, which is favorable for anticancer target therapy. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111217DOI Listing

LINC00319 Promotes Osteosarcoma Progression by Regulating the miR-455-3p/NFIB Axis.

J Gene Med 2020 Jul 4:e3248. Epub 2020 Jul 4.

Department of Psychology, Huangshi Psychiatric Hospital, Huangshi, Hubei, P.R. China.

Background: Numerous studies have shown that the aberrant expression of lncRNAs is associated with the development and metastasis of osteosarcoma (OS). However, the role and function of LINC00319 in regulating OS progression is unknown. The current study aimed to reveal the function and related mechanism of LINC00319 in OS. Read More

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http://dx.doi.org/10.1002/jgm.3248DOI Listing

Determination of Immediate Kinetic Growth Retardation in Physically Plasma-treated Cells by Experimental and Modelling Data.

Anticancer Res 2020 Jul;40(7):3743-3749

Department of Gynecology and Gynecological Oncology, University Hospital Bonn, Bonn, Germany

Background/aim: The antiproliferative effects of cold atmospheric plasma (CAP) make it a promising application option in oncology. The aim of the present study was to examine whether short-term CAP treatment leads to an initial partial elimination of the treated cells or to long-term impairement and inhibition of cell growth.

Materials And Methods: Cells were treated with CAP and biostatistical modelling was used to estimate growth rates over the incubation time. Read More

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http://dx.doi.org/10.21873/anticanres.14363DOI Listing

Long non-coding RNA LINC00426 contributes to doxorubicin resistance by sponging miR-4319 in osteosarcoma.

Biol Direct 2020 Jul 3;15(1):11. Epub 2020 Jul 3.

Department of Orthopaedic Trauma, Trauma Center of Fujian, The First Affiliated Hospital of Fujian Medical University, No.20, Chazhong Road, Taijiang District, Fuzhou, 350005, Fujian, China.

Background: LINC00426 is a newly identified long non-coding RNA (lncRNA) with unacknowledged biological roles. Here we set out to characterize the expression status of LINC00426 in osteosarcoma and understand its mechanistic involvement in incidence of doxorubicin (Dox) resistance.

Methods: The relative expression of LINC00426 and miR-4319 was determined by real-time PCR. Read More

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http://dx.doi.org/10.1186/s13062-020-00265-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333256PMC

Anti-osteosarcoma effect of hydroxyapatite nanoparticles both in vitro and in vivo by downregulating the FAK/PI3K/Akt signaling pathway.

Biomater Sci 2020 Jul 3. Epub 2020 Jul 3.

Department of Spine Surgery, Beijing JiShuiTan Hospital, Peking University, Beijing 100035, China.

Numerous studies have reported that hydroxyapatite nanoparticles (nano-HAPs) can inhibit the proliferation of a variety of tumor cells and this effect is different in different carcinoma cells. However, the effect of nano-HAPs on osteosarcoma cell proliferation has not been well understood thus far. In this study, we first showed that our synthesized nano-HAPs reduced cell viability and inhibited migration and invasion of OS-732 cells in a concentration-dependent manner. Read More

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http://dx.doi.org/10.1039/d0bm00898bDOI Listing

Primary breast telangiectatic osteosarcoma: a rare entity and a potential diagnostic pitfall.

Pathology 2020 Jun 29. Epub 2020 Jun 29.

Department of Pathology, Guangdong Provincial People's Hospital/Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2020.04.013DOI Listing

Extremely elevated serum alkaline phosphatase level upon treatment with teriparatide: a case report.

J Med Case Rep 2020 Jul 3;14(1):87. Epub 2020 Jul 3.

Rheumatology Research Center, Tehran University of Medical Sciences (TUMS), PO-Box: 1411713137, Tehran, Iran.

Background: Teriparatide is a homolog of human parathyroid hormone (1-34), which is approved for the treatment of postmenopausal and glucocorticoid-induced osteoporosis. Several minor and transient side effects have been reported for teriparatide. However, controversial findings showed an increased risk of more significant adverse effects, including osteosarcoma in humans, although this finding has been demonstrated primarily in murine models. Read More

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http://dx.doi.org/10.1186/s13256-020-02416-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333273PMC

Co-localization of Interleukin-1α and Annexin A2 at the plasma membrane in response to oxidative stress.

Cytokine 2020 Jun 29;133:155141. Epub 2020 Jun 29.

Department of Biomedicine, Faculty of Medicine, University of Bergen, Bergen, Norway.

Interleukin-1α (IL-1α) and Annexin A2 (AnxA2) are pleiotropic molecules with both intracellular and extracellular roles. They share several characteristics including unconventional secretion aided by S100 proteins, anchoring of the externalized proteins at the outer surface of the plasma membrane and response to oxidative stress. Although IL-1α and AnxA2 have been implicated in a variety of biological processes, including cancer, little is known about the mechanisms of their cellular release. Read More

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http://dx.doi.org/10.1016/j.cyto.2020.155141DOI Listing

Overexpression of klotho suppresses growth and pulmonary metastasis of osteosarcoma in vivo.

Genet Mol Biol 2020 ;43(2):e20190229

Shanghai Fengxian District Central Hospital, Department of Orthopedics, Shanghai, China.

Klotho is originally discovered as an anti-aging gene and knock-out of klotho accelerates aging in mice. Subsequent studies support the anti-carcinogenesis role of klotho in a variety of human malignancies. The present study investigated the role of klotho on growth and metastasis of osteosarcoma cells. Read More

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http://dx.doi.org/10.1590/1678-4685-GMB-2019-0229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263425PMC
January 2020

miR-497 inhibits tumor growth and migration of osteosarcoma by targeting plexinA4 and CDK6.

Neoplasma 2020 Jul 2. Epub 2020 Jul 2.

Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, China.

MicroRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level which have been reported to be involved in the pathogenesis of various cancers. In the present study, we found that miR-497 was downregulated in osteosarcoma tissues. Gain and loss of function studies were carried out to investigate the effect of miR-497 on the growth of osteosarcoma cells. Read More

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http://dx.doi.org/10.4149/neo_2020_200108N26DOI Listing

Hurthle cell carcinoma in childhood: A retrospective analysis of five cases and review of pediatric literature.

Pediatr Blood Cancer 2020 Jul 2:e28300. Epub 2020 Jul 2.

Division of Pediatrics, Department of Human Pathology in Adulthood and Childhood, University of Messina, Messina, Italy.

Background: the available studies on Hurthle cell carcinoma (HCC) in pediatric age are scarce and based on isolated case reports. Aims of the present study were to review the available pediatric literature on HCC (2000-2019), to describe the cohort of children with this cancer histotype, and to estimate its relative prevalence in pediatric age.

Procedure: We retrospectively reconstructed an HCC course in five patients < 19 years who were identified in our departments during the period 2000-2019, and we reviewed the available pediatric studies on this differentiated thyroid cancer (DTC) variant. Read More

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http://dx.doi.org/10.1002/pbc.28300DOI Listing

Alterations in Muscle Architecture: A Review of the Relevance to Individuals After Limb Salvage Surgery for Bone Sarcoma.

Front Pediatr 2020 16;8:292. Epub 2020 Jun 16.

Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD, United States.

Osteosarcoma and Ewing's sarcoma are the most common primary bone malignancies affecting children and adolescents. Optimal treatment requires a combination of chemotherapy and/or radiation along with surgical removal when feasible. Advances in multiple aspects of surgical management have allowed limb salvage surgery (LSS) to supplant amputation as the most common procedure for these tumors. Read More

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http://dx.doi.org/10.3389/fped.2020.00292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308581PMC

Down-Regulation of Ribosomal Protein RPS21 Inhibits Invasive Behavior of Osteosarcoma Cells Through the Inactivation of MAPK Pathway.

Cancer Manag Res 2020 25;12:4949-4955. Epub 2020 Jun 25.

Department of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan City, Shanxi Province 030001, People's Republic of China.

Objective: The goal of our present study was to explore the expression level, biological function, and underlying molecular mechanism of ribosomal protein s21 (RPS21) in human osteosarcoma (OS).

Methods: Firstly, we evaluated the expression of RPS21 in OS tissue samples based on the Gene Expression Omnibus (GEO) datasets and also measured the RPS21 expression of OS cell lines (MG63, and U2OS) by quantitative real-time polymerase chain reaction (qRT-PCR). siRNA interference method was used to reduce the expression of RSP21 in the OS cells. Read More

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http://dx.doi.org/10.2147/CMAR.S246928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323807PMC

Effects of vitamin C on osteoblast proliferation and osteosarcoma inhibition using plasma coated hydroxyapatite on titanium implants.

Surf Coat Technol 2020 Jul 15;394. Epub 2020 Apr 15.

W. M. Keck Biomedical Materials Research Laboratory School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington 99164, United States.

Plasma-sprayed hydroxyapatite (HAp) coated titanium (Ti) implants are being extensively used in orthopedic surgeries and post-tumor resection to repair load-bearing segmental bone defects. In this study, vitamin C, an abundantly available natural biomolecule, is loaded onto plasma-sprayed HAp-coated commercially pure titanium (cpTi) surface to evaluate its chemopreventive and osteogenic properties, suggesting its clinical significance as an alternative or adjunct therapy in the treatment for osteosarcoma bone resection. Controlled release of vitamin C from HAp coated cpTi implant is assessed by drug release study, where Korsmeyer-Peppas model was applied to understand the release kinetics. Read More

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http://dx.doi.org/10.1016/j.surfcoat.2020.125793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328859PMC

Late mortality in survivors of childhood cancer in Hungary.

Sci Rep 2020 Jul 1;10(1):10761. Epub 2020 Jul 1.

2nd Department of Pediatrics, Semmelweis University, 7-9. Tűzoltó Str., 1094, Budapest, Hungary.

The Hungarian Pediatric Oncology Network provides centralized treatment and population-based registration for cases of childhood cancer since 1973. We collected and analized data on late mortality, secondary malignancies and cardiac diseases in survivors (> 5 years) of childhood cancer to evaluate long-term risks. We extracted all solid tumour cases (3,650 followed up for 5-39. Read More

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http://dx.doi.org/10.1038/s41598-020-67444-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329824PMC

Intraocular extraskeletal osteosarcoma in a rabbit (Oryctolagus cuniculus).

J Vet Med Sci 2020 Jul 1. Epub 2020 Jul 1.

Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Nihon University.

An 8-year-and-9-month-old male, lop-eared rabbit (Oryctolagus cuniculus) presented with gradual enlargement of the left eye to 4 × 4 × 4 cm and exophthalmos. The animal died 3 months later, and necropsy was performed. On gross pathology, the intraocular tissue was effaced and occluded by a hard, light-gray mass. Read More

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http://dx.doi.org/10.1292/jvms.20-0220DOI Listing

Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion) in Pediatric Phalanges.

J Hand Surg Am 2020 Jun 28. Epub 2020 Jun 28.

Associate Professor for Orthopaedic Surgery, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH; Cirugía Ortopédica y Traumatología, Hospital Universitario Infantil Niño Jesús, Madrid, Spain. Electronic address:

Bizarre parosteal osteochondromatous proliferation, or Nora tumor, is an uncommon lesion affecting the tubular bones of the hands and feet. Normally arising from the cortical surface and periosteum of these bones, these lesions histologically consist of a hypercellular cartilaginous cap covering a bony stalk that is surrounded by ossified areas and spindle cell stroma. The differential diagnosis includes conditions involving the periosteum such as chondrosarcoma, parosteal osteosarcoma, osteochondroma, turret exostosis, and florid reactive periostitis. Read More

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http://dx.doi.org/10.1016/j.jhsa.2020.05.002DOI Listing

Cadmium in bone cement induces necrosis and decreases the viability of residual osteosarcoma cells: A xenograft study.

Acta Orthop Traumatol Turc 2020 Jul 1. Epub 2020 Jul 1.

Department of Orthopedics, Dokuz Eylül University, School of Medicine, İzmir, Turkey.

Objective: The aim of this study was to show whether local application of cadmium-impregnated bone cement can induce apoptosis and decrease the viability of residual osteosarcoma (OS) cells in nude mice.

Methods: K7M2 tumorigenic OS cell line was cultivated in vitro. The xenograft tumor model was formed by subcutaneously adding the tumor cells to athymic nude mice. Read More

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http://dx.doi.org/10.5152/j.aott.2020.20247DOI Listing

Aurora-B Promotes Osteosarcoma Cell Growth and Metastasis Through Activation of the NPM1/ERK/NF-κβ/MMPs Axis.

Cancer Manag Res 2020 23;12:4817-4827. Epub 2020 Jun 23.

Department of Orthopedic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, People's Republic of China.

Purpose: Osteosarcoma (OS) is the most common primary malignant tumor of the bone in young adolescents and children. We explored the underlying mechanism of Aurora-B in promoting OS cell proliferation and metastasis.

Patient And Methods: Bioinformatics was employed to predict the substrate of Aurora-B. Read More

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http://dx.doi.org/10.2147/CMAR.S252847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320907PMC

Cell Differentiation Agent-2 (CDA-2) Inhibits the Growth and Migration of Saos-2 Cells via miR-124/MAPK1.

Cancer Manag Res 2020 15;12:4541-4548. Epub 2020 Jun 15.

Department of Oncology, Hospital of Ruikang Affiliated to Guangxi University of Chinese Medicine, Guangxi, People's Republic of China.

Background: CDA-2 (cell differentiation agent 2), isolated from healthy human urine, exerts antitumor effects in multiple types of cancer cells. However, its role in osteosarcoma has not been studied.

Methods: The MTT assay was used to examine the cell proliferation rate. Read More

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http://dx.doi.org/10.2147/CMAR.S248851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304673PMC

LncRNA TDRG1 Promotes Proliferation, Invasion and Epithelial-Mesenchymal Transformation of Osteosarcoma Through PI3K/AKT Signal Pathway.

Cancer Manag Res 2020 15;12:4531-4540. Epub 2020 Jun 15.

Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan Province, People's Republic of China.

Objective: This study aimed to investigate the effect of long non-coding TDRG1 on proliferation and migration of osteosarcoma cells through PI3K/AKT signaling pathway.

Materials And Methods: Altogether 87 cases of osteosarcoma tissues and adjacent tissues were collected, and osteosarcoma cells and osteoblasts were purchased. The expression of LncRNA TDRG1 in tissues and cells was detected by RT-PCR. Read More

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http://dx.doi.org/10.2147/CMAR.S248964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304679PMC

Management of Refractory Pediatric Sarcoma: Current Challenges and Future Prospects.

Onco Targets Ther 2020 8;13:5093-5112. Epub 2020 Jun 8.

Department of Medical Oncology, Tata Medical Center, Kolkata, India.

Paediatric sarcomas are a heterogeneous group of disorders constituting bone sarcoma and various soft tissue sarcomas. Almost one-third of these presents with metastasis at baseline and another one-third recur after initial curative treatment. There is a huge unmet need in this cohort in terms of curative options and/or prolongation of survival. Read More

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http://dx.doi.org/10.2147/OTT.S193363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293381PMC

Anticancer Effects of Cold Atmospheric Plasma in Canine Osteosarcoma Cells.

Int J Mol Sci 2020 Jun 26;21(12). Epub 2020 Jun 26.

College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea.

Osteosarcoma is known to be one of the frequently occurring cancers in dogs. Its prognosis is usually very poor, with a high incidence of lung metastasis. Although radiation therapy has become a major therapeutic choice for canine osteosarcoma, the high costs and unexpected side effects prevent some patients from considering this treatment. Read More

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http://dx.doi.org/10.3390/ijms21124556DOI Listing