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Carcinogenesis 2019 Feb 16. Epub 2019 Feb 16.

CAS, Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.

Benzene, a widespread environmental pollutant, induces DNA double-strand breaks (DSBs) and DNA repair, which may further lead to oncogenic mutations, chromosomal rearrangements and leukemogenesis. However, the molecular mechanisms underlying benzene-induced DNA repair and carcinogenesis remain unclear. The human osteosarcoma cell line (U2OS/DR-GFP), which carries a GFP-based homologous recombination (HR) repair reporter, was treated with hydroquinone, one of the major benzene metabolites, to identify the potential effects of benzene on DSB HR repair. Read More

Oncogene 2019 Feb 15. Epub 2019 Feb 15.

Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Since the publication of this paper, the authors have noticed that the article contains an error in Figure 3e (TSN, 50 nM). As a result of the misfiling of the data, the incorrect image was inadvertently inserted in Figure 3e during figure preparation. The corrected image is shown in this correction. Read More

J Vet Intern Med 2019 Feb 15. Epub 2019 Feb 15.

Ohio State University Veterinary Medical Center, Columbus, Ohio.

Background: Factors indicative of a negative prognosis for appendicular osteosarcoma (OSA) in dogs are visible metastatic disease, location, and size of lesion. In human medicine maximum standard uptake value (SUV ), as measured on a fluorine flourodeoxyglucose positron emission tomography/computed tomography ( F-FDG PET/CT), is prognostic for survival for several tumor types.

Objective: Determine if SUV is associated with progression-free interval (PFI) and determination of survival in dogs with appendicular OSA. Read More

J Biomol Struct Dyn 2019 Feb 15:1-9. Epub 2019 Feb 15.

a Faculty of Pharmacy , Integral University , Lucknow , Uttar Pradesh , India .

Chrysin, a bioactive flavonoid, was investigated for its potential to inhibit the activity of I-kappa-B kinase epsilon (IKKe) / Tank Binding Kinase-1(TBK1) an enzyme responsible for production of pro inflammatory cytokine and suppression of energy expenditure genes, finally causing insulin resistance and obesity. Expressions of majority of polyinosinic-polycytidylic acid (poly IC) mediated genes are mediated through Toll/interleukin-1 receptor domainߝcontaining adapter-inducing interferon (TRIF) dependent signalling pathway. To check the therapeutic potential of chrysin its effect was examined on Toll/interleukin-1 receptor domainߝcontaining adapter-inducing interferon (TRIF) dependent pathway. Read More

Vet Comp Oncol 2019 Feb 15. Epub 2019 Feb 15.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Midlothian.

The inducible inflammatory enzyme cyclooxygenase-2 (COX-2) and its product prostaglandin E2 (PGE ) are prominent tumour promoters, and expression of COX-2 is elevated in a number of tumours of both humans and canines. Targeting COX-2 in cancer is an attractive option due to readily available non-steroidal anti-inflammatory drugs (NSAIDs), and there is a clear epidemiological link between NSAID use and cancer risk. In this study we aim to establish the anti-tumourigenic effects of the selective, long-acting COX-2 inhibitor mavacoxib. Read More

Cancer Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo, 060-8556, Japan.

Osteosarcoma is the most common malignancy of bone that affects young people. Neoadjuvant chemotherapy and surgery have significantly improved the prognosis. However, the prognosis of non-responders to chemotherapy is still poor. Read More

Biochem Biophys Res Commun 2019 Feb 11. Epub 2019 Feb 11.

Department of Orthopaedics, The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710077, China. Electronic address:

Aberrant miRNAs play important roles in tumor development and progression. Previous studies reported that miR-552 was dysregulated expressed in multiple cancers. However, its biological effects and underlying mechanism in osteosarcoma remains largely unknown. Read More

Int J Cancer 2019 Feb 13. Epub 2019 Feb 13.

Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan 430030, China.

The P2X7 receptor, an ATP-gated ion channel, is critical for cancer cell growth, invasiveness, and angiogenesis. Previous studies indicate that P2X7 regulates osteoblast proliferation and osteodeposition and that high P2X7 expression has a pro-growth effect in osteosarcoma. However, how it functions in osteosarcoma cell growth and metastasis is not clear. Read More

FEBS Open Bio 2019 Feb 7;9(2):226-240. Epub 2019 Jan 7.

Orthopaedics China-Japan Union Hospital of Jilin University China.

Cyclooxygenase-2 (COX-2), a key enzyme in arachidonic acid metabolism, is involved in several cancers, including osteosarcoma. The prognostic significance of COX-2 in osteosarcoma remains controversial. This study was to analyze the potential clinical and prognostic effects of COX-2 protein expression in patients with osteosarcoma. Read More

ACS Appl Mater Interfaces 2019 Feb 13. Epub 2019 Feb 13.

Nowadays chemotherapy is the main treatment for osteosarcoma disease, even if limited by the lack of selectivity between healthy and cancer cells during the inhibition of cell division. Herein, we propose the use of few-layer black phosphorous (2D bP) as an alternative tool for osteosarcoma treatment and report how 2D bP can stimulate newly forming bone tissue generation after osteosarcoma resection. In our study, we have developed an in vitro model to evaluate the efficacy of 2D bP material with and without near-infrared light irradiation treatment and we have demonstrated that the presence of 2D bP without treatment inhibits the metabolic activity of osteosarcoma cells (SAOS-2), while inducing both the proliferation and the osteogenic differentiation of human pre-osteoblast cells (HOb) and mesenchymal stem (hMSC) cells. Read More

Am J Cancer Res 2019 1;9(1):36-52. Epub 2019 Jan 1.

Department of Emergency, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, Henan, P. R. China.

microRNAs (miRNAs) are frequently aberrantly expressed in osteosarcoma (OS) and are implicated in its development. Dysregulation of miR-758 has been reported in various human malignancies. However, whether miR-758 is involved in the oncogenesis and progression of OS remains unclear. Read More

Cold Spring Harb Mol Case Stud 2019 Feb 12. Epub 2019 Feb 12.

Children's Hospital Los Angeles;

Background: Advancing the clinical utility of whole exome sequencing (WES) for patients with suspected genetic disorders is largely driven by bioinformatics approaches that streamline data processing and analysis.

Methods: Herein, we describe our experience with implementing a semi-automated and phenotype-driven WES diagnostic workflow, incorporating both the DRAGEN pipeline and the Exomiser variant prioritization tool, at an academic children's hospital with an ethnically diverse pediatric patient population.

Results: We achieved a 41% molecular diagnostic rate for 66 duo-, quad- or trio- WES cases, and 28% for 40 singleton-WES cases. Read More

Med Sci (Basel) 2019 Feb 11;7(2). Epub 2019 Feb 11.

Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08 Bratislava, Slovakia.

Both adolescents and children suffer from osteosarcoma, localized in the metaphysis of the long bones. This is the most common primary high-grade bone tumor in this patient group. Early tumor detection is the key to ensuring effective treatment. Read More

Cancer Lett 2019 Feb 9. Epub 2019 Feb 9.

The Second Affiliated Hospital & Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, PR China. Electronic address:

Many studies have uncovered the essential role of ZBTB7A in regulating tumourigenesis. However, its functional significance in cell responses to endoplasmic reticulum stress (ER stress) remains poorly understood. Here we report that ZBTB7A functions as an important prosurvival factor in osteosarcoma cells undergoing pharmacological ER stress-induced by tunicamycin (TM) or thapsigargin (TG). Read More

J Mater Sci Mater Med 2019 Feb 12;30(2):22. Epub 2019 Feb 12.

Department of Medical Chemistry, Medical University of Gdansk, Debinki 1, 80-211, Gdansk, Poland.

Due to development of nanotechnology and gold nanoparticles (AuNPs) increasing use in different areas of medicine, especially in oncology, better understanding of their potential cytotoxicity is necessary to protect patients safety. Shape and size of AuNPs is an important modulator of their cytotoxicity. Therefore, we investigated the cytotoxicity of AuNPs rods (≈39 nm length, 18 nm width), AuNPs stars (≈ 215 nm) and AuNPs spheres (≈ 6. Read More

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Department of Orthopedics, Shanghai Songjiang Central Hospital, Shanghai, China.

Osteosarcoma is the most common bone tumor and characterizes a high metastatic potential. In osteosarcoma, angiogenesis is reported to be closely associated with tumor metastasis. Understanding the underlying mechanisms and accordingly developing therapeutic strategies are urgently desired. Read More

Int J Biol Sci 2019 24;15(3):668-679. Epub 2019 Jan 24.

Department of Orthopaedics, Shanghai General Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China.

Osteosarcoma (OS) is the most common primary bone malignancy in adolescents. One major obstacle for current OS treatment is drug-resistance. Raddeanin A (RA), an oleanane-type triterpenoid saponin, exerts anti-tumor effects in several tumor models, but the effect of RA in human drug-resistant OS remained to be elucidated. Read More

Int J Biol Sci 2019 1;15(2):386-394. Epub 2019 Jan 1.

Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.

Arsenic trioxide (ATO) has been well recognized as an anti-tumor agent for various human cancers. Recently, the blue light emitting diodes (LEDs)-based therapy has also been demonstrated to be potential therapeutic strategies for several cancers. However, the combination effects of ATO and blue LED on tumor suppression are still unclear. Read More

Rev Esp Cir Ortop Traumatol 2019 Feb 7. Epub 2019 Feb 7.

Unidad de Raquis, Servicio de Traumatología y Ortopedia Infantil, Hospital Infantil Universitario Niño Jesús, Madrid, España.

Introduction And Objective: Osteosarcoma is the most frequent malignant spinal tumour in the paediatric age group. Diagnosis and early treatment of this pathology is essential for a good prognosis. The aim of this study was to present the results of treatment of paediatric patients with lumbar osteosarcoma and conduct a literature review. Read More

Cancer Sci 2019 Feb 11. Epub 2019 Feb 11.

Division of Cell Physiology, Department of Physiology and Cell biology, Graduate School of Medicine, Kobe University, Kobe, 650-0017, Japan.

Collective invasion is an important strategy of cancers of epithelial origin, including colorectal cancer (CRC), to infiltrate efficiently into local tissues as collective cell groups. Within the groups, cells at the invasive front, called leader cells, are highly polarized and motile, thereby providing the migratory traction that guides the follower cells. However, its underlying mechanisms remain unclear. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Feb;33(2):170-176

Department of Orthopedics, Affiliated Nanjing Hospital (the First Hospital of Nanjing), Nanjing Medical University , Nanjing Jiangsu, 210006, P.R.China;Digital Medical Institute, Nanjing Medical University, Nanjing Jiangsu, 210006,

Objective: To investigate the value of integrin α β targeted microPET/CT imaging with Ga-NODAGA-RGD as radiotracer for the detection of osteosarcoma and theranostics of osteosarcoma lung metastasis.

Methods: The Ga-NODAGA-RGD and Lu-NODAGA-RGD were prepared via one-step method and their stability and integrin α β binding specificity were investigated . Forty-one nude mice were injected with human MG63 osteosarcoma to established the animal model bearing subcutaneous osteosarcoma ( =21), osteosarcoma in tibia ( =5), and osteosarcoma pulmonary metastatic ( =15). Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Feb;33(2):131-137

Department of Orthopedic Oncology Surgery, Beijing Ji Shui Tan Hospital, Beijing, 100035,

Objective: To investigate the feasibility and effectiveness of proximal tibial hemiprosthesis replacement in the first stage and prosthesis revision in the second stage in reducing the risk of length discrepancy of limbs in children with proximal tibial osteosarcoma.

Methods: Between 2009 and 2013, 3 children with conventional osteosarcoma at the proximal tibia (stage ⅡB) were treated. There were 2 boys and 1 girl. Read More

Biochem Biophys Res Commun 2019 Feb 6. Epub 2019 Feb 6.

Department of Orthopaedics, Hospital of Zhengzhou University, Zhengzhou, 450052, PR China. Electronic address:

Osteosarcoma (OS) is an invasive cancer in the skeletal system. The molecular mechanism of its etiology and pathogenesis are still not clear, so the effective treatment strategy of OS needs further research. First, we analyzed the expression level and prognostic ability of the RNA helicase DDX10 in OS patients based on the data obtained from GEO database. Read More

J Orthop Res 2019 Feb 9. Epub 2019 Feb 9.

Research Service, VA Greater Los Angeles Healthcare System, North Hills, California, USA.

The correlation between BMP-2 and osteosarcoma growth has gained increased interest in the recent years, however, there is still no consensus. In this study, we tested the effects of BMP-2 on osteosarcoma cells through both in vitro and in vivo experiments. The effect of BMP-2 on the proliferation, migration and invasion of osteosarcoma cells was tested in vitro. Read More

Biochem Biophys Res Commun 2019 Mar 5;510(3):479-486. Epub 2019 Feb 5.

Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address:

Osteosarcoma (OS) has emerged as the most common primary musculoskeletal malignant tumor which affects children and adolescents. A growing number of relevant studies have shown that many microRNAs (miRNAs) play a vital regulatory role in the etiology of various types of cancer. miR-1258 has been widely studied in various cancers, but there have been few studies of its role in OS. Read More

Nanotechnology 2019 Feb 8. Epub 2019 Feb 8.

Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Medicinal Plant Development, Beijing, CHINA.

In order to achieve the purpose of targeting treatment of osteosarcoma, we developed novel paclitaxel (PTX) nanoparticles (Nps) coated with polydopamine (PDA) and grafted by alendronate (ALN) as ligand. Dopamine can be easily polymerized on various surfaces to form a thin PDA film in alkaline environment, which provided a versatile platform to perform secondary reactions for compounds without functional groups. The targeting Nps had a mean particle size of 290. Read More

PLoS One 2019 8;14(2):e0211969. Epub 2019 Feb 8.

Department of Radiology, Seoul National University Hospital, Jongno-gu, Seoul, Republic of Korea.

Objective: To retrospectively evaluate the value of computerized 3D texture analysis for differentiating pulmonary metastases from non-metastatic lesions in pediatric patients with osteosarcoma.

Materials And Methods: This retrospective study was approved by the institutional review board. The study comprised 42 pathologically confirmed pulmonary nodules in 16 children with osteosarcoma who had undergone preoperative computed tomography between January 2009 and December 2014. Read More

Acad Pathol 2019 Jan-Dec;6:2374289518820337. Epub 2019 Jan 10.

Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.

http://journals.sagepub.com/doi/10. Read More

Front Pharmacol 2018 24;9:1558. Epub 2019 Jan 24.

Department of Joint Surgery, Affiliated Hospital, Weifang Medical University, Weifang, China.

Osteosarcoma (OS) is a common malignant primary bone tumor. Its mechanism of development and progression is poorly understood. Currently, there is no effective therapeutic regimens available for the treatment of OS. Read More

Clin Cancer Res 2019 Feb 7. Epub 2019 Feb 7.

Radiology, Baylor College of Medicine.

Purpose: The prognosis of metastatic osteosarcoma continues to be poor. We hypothesized that alpha-emitting, bone-targeting radium 223 dichloride (RaCl) can be safely administered to patients with osteosarcoma and that early signals of response or resistance can be assessed by quantitative and qualitative correlative imaging studies and biomarkers.

Experimental Design: A 3+3 phase I, dose-escalation trial of RaCl (50, 75, and 100 kBq/kg) was designed in recurrent/metastatic osteosarcoma patients aged ≥15 years. Read More

Medicine (Baltimore) 2019 Feb;98(6):e14442

Department of Emergency Surgery, First Affiliated Hospital of Jiamusi University, Jiamusi, China.

Background: This systematic review will address the efficacy and safety of methotrexate, doxorubicin, and cisplatin (MAP) for the treatment of patients with osteosarcoma.

Methods: We will retrieve the studies from the following 9 electronic databases: Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, the Cumulative Index to Nursing and Allied Health Literature, the Allied and Complementary Medicine Database, and Chinese Biomedical Literature Database, China National Knowledge Infrastructure, VIP Information, and Wanfang Data. Two independent researchers will screen and select the relevant papers for eligibility after the search strategies have been conducted. Read More

Medicine (Baltimore) 2019 Feb;98(6):e14302

Department of Orthopedics, The Second Affiliated Hospital of Xi'an Jiaotong University.

Transcriptome profiling of osteosarcoma (OS) by next generation sequencing technology (NGS) has been broadly performed by previous researches, which uncovers a large number protein-coding driver genes, facilitates our understanding of the molecular mechanisms of OS formation, progression and metastasis. Recently, more and more researchers realize the importance of long non-coding RNAs (lncRNAs) on the development of OS. However, few studies focus on discovering driver lncRNAs. Read More

JAMA Oncol 2019 Feb 7. Epub 2019 Feb 7.

Carnegie Museum of Natural History, Pittsburgh, Pennsylvania.

Orv Hetil 2019 Feb;160(6):228-234

Sebészeti Klinika, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Semmelweis u. 8., 6720.

Li-Fraumeni syndrome is a rare genetic disorder predisposing the individual to multiple different cancer types, caused by a germline mutation of the TP53 or CHEK2 genes inherited in an autosomal dominant manner. We hereby describe the case of a family with Li-Fraumeni syndrome. An asymptomatic 40-year-old female was diagnosed with primary lung leiomyosarcoma (T3N0), adenocarcinoma (T1aN0), and inflammatory myofibroblastic tumor, which were surgically removed without further treatment. Read More

Methods Mol Biol 2019 ;1914:331-342

Institut de Cancérologie de l'Ouest, INSERM, UMR1232, Université de Nantes, Université d'Angers, Tumour Heterogeneity and Precision Medicine, Nantes, France.

This chapter describes the procedures for inducing bone sarcoma in mice. Two models based on inoculation of cancer cells in paraosseous and intraosseous site will be described. In addition to providing technical aspects of anesthesia and surgical options, key information of cell preparation and postoperative follow-up will be discussed. Read More

DNA Cell Biol 2019 Feb;38(2):170-175

2 Department of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

Long noncoding RNA host gene 16 (SNHG16) has a key role in a variety of cancer progression. However, the role and mechanism of SNHG16 in osteosarcoma (OS) remain unknown. In this study, we examined the functional role of SNHG16 in OS cells through knocked-down SNHG16 by using siRNA. Read More

Methods Mol Biol 2019 ;1928:69-76

Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.

The mitochondrial membrane potential (Δψ) drives the generation of ATP by mitochondria. Interestingly, Δψ is higher in many cancer cells comparted to healthy noncancerous cell types, providing a unique metabolic marker. This feature has also been exploited for therapeutic use by utilizing drugs that specifically accumulate in the mitochondria of cancer cells with high Δψ. Read More

Methods Mol Biol 2019 ;1866:133-148

AntiCancer, Inc., San Diego, CA, USA.

Cancer cells are methionine (MET) dependent compared to normal cells as they have an elevated requirement for MET in order to proliferate. MET restriction selectively traps cancer cells in the S/G phase of the cell cycle. The cell cycle phase can be visualized by color coding with the fluorescence ubiquitination-based cell cycle indicator (FUCCI). Read More

J Cell Mol Med 2019 Feb 5. Epub 2019 Feb 5.

Department of Orthopedics, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Although the application of multiple chemotherapy brought revolutionary changes to improve overall survival of osteosarcoma patients, the existence of multidrug resistance (MDR) has become a great challenge for successful osteosarcoma treatment in recent decades. Substantial studies have revealed various underlying mechanisms of MDR in cancers. As for osteosarcoma, evidence has highlighted that microRNAs (miRNAs) can mediate in the processes of DNA damage response, apoptosis avoidance, autophagy induction, activation of cancer stem cells, and signal transduction. Read More

Cureus 2018 Nov 28;10(11):e3655. Epub 2018 Nov 28.

Radiology, Hyogo College of Medicine, Nishinomiya, JPN.

We report here a case of periosteal sarcoma in a 10-year-old female, along with quantitative values obtained with bone single photon emission computed tomography/computed tomography (SPECT/CT), which were useful to evaluate treatment response to preoperative chemotherapy. Pretreatment radiograph images of the lower leg showed cortical thickening eroded by a broad-based soft-tissue mass without the involvement of the underlying cortex, while computed tomography (CT) revealed a small juxtacortical mass with thick calcification and periosteal reaction. In magnetic resonance imaging (MRI), the mass showed hypointensity in the inner part and isointensity in the outer part in T1-weighted images, while the inner part showed hypointensity and the outer part hyperintensity in T2-weighted images. Read More

Evid Based Complement Alternat Med 2019 6;2019:1410495. Epub 2019 Jan 6.

Department of Orthopedics, No. 371 Central Hospital of PLA, Xinxiang, Henan, China.

Background: As the malignant tumor with the highest incidence in teenagers, osteosarcoma has become a major problem in oncology research. In addition to surgical management, the pharmacotherapeutic strategy for osteosarcoma treatment is an attractive way to explore. It has been demonstrated that biochanin A has an antitumor capacity on multiple kinds of solid tumor, including osteosarcoma. Read More

Gene 2019 Feb 2. Epub 2019 Feb 2.

Department of Orthopedics, Zhoukou Cetral Hospital, Zhoukou City, Henan Province, 466000, PR China.

MicroRNAs (miRNAs) play an essential role in cancer development. Several studies have indicated that miRNAs mediate tumorigenesis processes, such as inflammation, proliferation, apoptosis and invasion. In the present study, we aimed to investigate the role of the microRNA-185 (miR-185) on the proliferation, migration and invasion of osteosarcoma (OS). Read More

Oncol Rep 2019 Feb 4. Epub 2019 Feb 4.

Department of Orthopedics, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu 210002, P.R. China.

The overall survival rate of patients with osteosarcoma has remained unchanged for the last several decades. Therefore, novel drugs for osteosarcoma treatment are required. Isoliquiritigenin (ISL), a natural compound, has been demonstrated to inhibit the growth of various tumors. Read More

Mol Med Rep 2019 Jan 30. Epub 2019 Jan 30.

Department of Orthopedics Ward II, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, P.R. China.

Osteosarcoma (OS) is the most common primary bone malignancy. It predominantly occurs in adolescents, but can develop at any age. The age at diagnosis is a prognostic factor of OS, but the molecular basis of this remains unknown. Read More

Int J Cancer 2019 Feb 4. Epub 2019 Feb 4.

Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Osteosarcoma is the most common primary malignant bone tumor in children and adolescents, with highly aggressive behavior and early systemic metastasis. The survival rates for osteosarcoma remain unchanged over the past two decades. Studies aiming to find new or alternative therapies for patients with refractory osteosarcoma are urgently needed. Read More

Oncotarget 2019 Jan 4;10(2):161-174. Epub 2019 Jan 4.

Department of Orthopedic Surgery, University of Toyama, Toyama, Japan.

Lung metastasis markedly reduces the prognosis of osteosarcoma. Moreover, there is no effective treatment for lung metastasis, and a new treatment strategy for the treatment of osteosarcoma lung metastasis is required. Therefore, in this study, we investigated the suppressive effect of the microtubule inhibitor eribulin mesylate (eribulin) on lung metastasis of osteosarcoma. Read More

Dis Markers 2019 3;2019:4569718. Epub 2019 Jan 3.

Cancer Research Center and Translational Laboratory, Department of Medical Research, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.

Background: Osteosarcoma (OS) is the most common and most aggressive primary solid malignant bone tumor in children and young adults and has high rates of recurrence and metastasis. The endoplasmic reticulum (ER) stress pathway is important in regulating the chemo-responsiveness of cancer. However, the role of glucose-regulated protein 94 (GRP94) in regulating the response of OS to chemotherapy has never been explored. Read More