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Appl Bionics Biomech 2022 14;2022:4247670. Epub 2022 Jun 14.

Department of Orthopedics, The First Hospital of Lanzhou University, Lanzhou, 730000 Gansu, China.

Objective: This study is aimed at exploring the influence of circular RNA- (circRNA-) RANGAP1 targeting microRNA- (miR-) 542-3p/myosin regulatory light chain interacting protein (MYLIP) on the biological function of osteosarcoma (OS) cells.

Methods: Tumor tissues and normal tissues were collected from OS patients and circ-RANGAP1, miR-542-3p, and MYLIP expression was tested by RT-qPCR. The correlation between the clinicopathology/prognosis of patients with OS and circ-RANGAP1 expression was observed. Read More

Sensors (Basel) 2022 Jun 9;22(12). Epub 2022 Jun 9.

Department of Mechanical and Aerospace Engineering, Sapienza University of Rome, 00184 Rome, Italy.

The measurement of biological tissues' dielectric properties plays a crucial role in determining the state of health, and recent studies have reported microwave biosensing to be an innovative method with great potential in this field. Research has been conducted from the tissue level to the cellular level but, to date, cellular adhesion has never been considered. In addition, conventional systems for diagnosing tumor aggressiveness, such as a biopsy, are rather expensive and invasive. Read More

Pharmaceutics 2022 Jun 13;14(6). Epub 2022 Jun 13.

Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.

Metastatic osteosarcoma often results in poor prognosis despite the application of surgical en bloc excision along with chemotherapy. HO-3867 is a curcumin analog that induces cell apoptosis in several cancers, but the apoptotic effect and its mechanisms on osteosarcoma cells are still unknown. After observing the decrease in cellular viability of three human osteosarcoma U2OS, HOS, and MG-63 cell lines, and the induction of cellular apoptosis and arrest in sub-G1 phase in U2OS and HOS cells by HO-3867, the human apoptosis array showed that heme oxygenase (HO)-1 and cleaved caspase-3 expressions had significant increases after HO-3867 treatment in U2OS cells and vice versa for cellular inhibitors of apoptosis (cIAP)1 and X-chromosome-linked IAP (XIAP). Read More

Pharmaceuticals (Basel) 2022 Jun 8;15(6). Epub 2022 Jun 8.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

Polycaprolactone nanofibers are used as scaffolds in the field of tissue engineering for tissue regeneration or drug delivery. Polycaprolactone (PCL) is a biodegradable hydrophobic polyester used to obtain implantable nanostructures, which are clinically applicable due to their biological safety. Polydatin (PD), a glycosidic precursor of resveratrol, is known for its antioxidant, antitumor, antiosteoporotic, and bone regeneration activities. Read More

Molecules 2022 Jun 11;27(12). Epub 2022 Jun 11.

Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy.

Osteosarcoma (OS) is a malignant disease characterized by poor prognosis due to a high incidence of metastasis and chemoresistance. Recently, Licochalcone A (Lic-A) has been reported as a promising agent against OS. Starting from chalcones selected from a wide in-house library, a new series was designed and synthetized. Read More

Molecules 2022 Jun 9;27(12). Epub 2022 Jun 9.

Joint Research Centre for Engineering Biology, Zhejiang University-University of Edinburgh Institute, Zhejiang University, Haining 314400, China.

In the screening of novel natural products against cancer using an in vitro cancer cell model, we recently found that tanshinones from a traditional Chinese medicine, the rhizome of Bunge (Danshen), had potent effects on cell proliferation and migration. Especially for human osteosarcoma U-2 OS cells, tanshinones significantly enhanced the cell adherence, implying a possible role in cell adhesion and cell migration inhibition. In this work, therefore, we aimed to provide a new insight into the possible molecule mechanisms of dihydrotanshinone I, which had the strongest effects on cell adhesion among several candidate tanshinones. Read More

J Clin Med 2022 Jun 7;11(12). Epub 2022 Jun 7.

San Salvatore Hospital, 67100 L'Aquila, Italy.

Interventional Radiology (IR) has experienced an exponential growth in recent years. Technological advances of the last decades have made it possible to use new treatments on a larger scale, with good results in terms of safety and effectiveness. In musculoskeletal field, painful bone metastases are the most common target of IR palliative treatments; however, in selected cases of bone metastases, IR may play a curative role, also in combination with other techniques (surgery, radiation and oncology therapies, etc. Read More

Int J Mol Sci 2022 Jun 16;23(12). Epub 2022 Jun 16.

Department of Virology and Immunology, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19 Street, 20-033 Lublin, Poland.

Many organophosphorus compounds (OPs), especially various α-aminophosphonates, exhibit anti-cancer activities. They act, among others, as inhibitors of the proteases implicated in cancerogenesis. Thesetypes of inhibitors weredescribed, e. Read More

Int J Mol Sci 2022 Jun 8;23(12). Epub 2022 Jun 8.

Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, Avenida de Roma, s/n 33011 Oviedo, Spain.

Bone sarcomas have not shown a significant improvement in survival for decades, due, in part, to the development of resistance to current systemic treatments, such as doxorubicin. To better understand those mechanisms mediating drug-resistance we generated three osteosarcoma and one chondrosarcoma cell lines with a stable doxorubicin-resistant phenotype, both in vitro and in vivo. These resistant strains include a pioneer model generated from a patient-derived chondrosarcoma line. Read More

Healthcare (Basel) 2022 Jun 2;10(6). Epub 2022 Jun 2.

Center of Excellence in Smart Environment Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Osteosarcoma is a kind of bone cancer which generally starts to develop in the lengthy bones in the legs and arms. Because of an increase in occurrence of cancer and patient-specific treatment options, the detection and classification of cancer becomes a difficult process. The manual recognition of osteosarcoma necessitates expert knowledge and is time consuming. Read More

Cancers (Basel) 2022 Jun 20;14(12). Epub 2022 Jun 20.

Division of Radiation Oncology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.

This study aimed to retrospectively analyze the clinical outcomes of patients with pelvic and retroperitoneal bone and soft tissue sarcoma (BSTS). Overall, 187 patients with BSTS in the pelvis and retroperitoneal region treated at 19 specialized sarcoma centers in Japan were included. The prognostic factors related to overall survival (OS), local control (LC), and progression-free survival (PFS) were evaluated. Read More

Antioxidants (Basel) 2022 May 30;11(6). Epub 2022 May 30.

Department of Precision Medicine, Università degli Studi della Campania "Luigi Vanvitelli", Via L. De Crecchio 7, 80138 Naples, Italy.

Doxorubicin (Dox) is a highly effective chemotherapeutic agent employed in the handling of hematological and solid tumors. The effective use of Dox in cancer therapy has been seriously limited due to its well-known cardiotoxic side effects, mainly mediated by oxidative damage. Therefore, the identification of an effective and safe antagonist against Dox-induced cardiotoxicity remains a challenge. Read More

ACS Nano 2022 Jun 23. Epub 2022 Jun 23.

Key Laboratory of Smart Biomaterials of Zhejiang Province, College of Chemical and Biological Engineering of Zhejiang University, Hangzhou, Zhejiang 310027, PR China.

Pyroptosis has been reported to improve the immunosuppressive tumor microenvironment and may be a strategy to enhance osteosarcoma treatment. The extent to which modulation of mitochondria could induce tumor pyroptosis to enhance immunotherapy has not been characterized. We synthesized a mitochondria-targeting polymer micelle (OPDEA-PDCA), in which poly[2-(-oxide-,-diethylamino)ethyl methacrylate] (OPDEA) was used to target mitochondria and the conjugated dichloroacetate (DCA) was used to inhibit pyruvate dehydrogenase kinase 1 (PDHK1). Read More

Eur J Histochem 2022 Jun 23;66(3). Epub 2022 Jun 23.

Department of Orthopedic Surgery, Kindai University Hospital, Osaka-Sayama City, Osaka.

The cancer/testis antigens (CTAs), New York esophageal squamous cell carcinoma-1 (NY-ESO-1) and melanoma antigen gene (MAGE)-A4 are normally restricted to male germ cells but are aberrantly expressed in several cancers. Considering the limited information regarding their significance in osteosarcoma (OS), the purpose of this study was to determine the clinical significance of NY-ESO-1 and MAGE-A4 expression in OS. Nine patients with OS treated at Kindai University Hospital were included in the study. Read More

Curr Oncol 2022 Jun 15;29(6):4260-4266. Epub 2022 Jun 15.

Division of Medical Oncology, Canadian Sarcoma Research and Clinical Collaboration (CanSaRCC), Princess Margaret Cancer Centre-University Health Network, Toronto, ON M5G 2C1, Canada.

Sarcoma can present as locally advanced disease involving pleura for which extra-pleural pneumonectomy (EPP) may be the only surgical option to ensure adequate local control. Data were collected on patients who underwent EPP between January 2009 and August 2021 at Princess Margret Hospital and SickKids (Toronto) using the CanSaRCC (Canadian Sarcoma Research and Clinical Collaboration). Ten patients with locally advanced sarcoma involving the pleura, aged 4 to 59 years (median 19. Read More

Curr Oncol 2022 Jun 4;29(6):4081-4089. Epub 2022 Jun 4.

Department of Orthopedic Surgery, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahi-Machi, Abeno-Ku, Osaka 545-8585, Japan.

The aim of this study was to investigate the influence of systemic chemotherapy on the skeletal growth of young osteosarcoma patients as a treatment-related late adverse effect. We reviewed the height data of 20 osteosarcoma patients (13 males and 7 females) aged ≤18 years. The average (±SD) age at diagnosis was 14. Read More

Cell Prolif 2022 Jun 23:e13294. Epub 2022 Jun 23.

College of Kinesiology, Shenyang Sport University, Shenyang, China.

Background: Musculoskeletal disorder (MSD) are a class of inflammatory and degener-ative diseases, but the precise molecular mechanisms are still poorly understood. Noncoding RNA (ncRNA) N6-methyladenosine (m6A) modification plays an essential role in the pathophysiological process of MSD. This review summarized the interaction be-tween m6A RNA methylation and ncRNAs in the molecular regulatory mechanism of MSD. Read More

Front Oncol 2022 6;12:873323. Epub 2022 Jun 6.

Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Although clinicians and patients with extremity bone and soft tissue (EBST) are increasingly interested in limb salvage surgery (LSS), because of the minimal damage to physical appearance and function, however, there is still a lack of large-scale population studies on whether LSS improves the prognosis of patients.

Purpose: The aim of this study was to compare the survival of patients with EBST sarcomas after receiving LSS and amputation.

Methods: To conduct the population-based study, we identified 6,717 patients with a histologically diagnosed bone sarcoma and 24,378 patients with a histologically diagnosed soft tissue sarcoma from the Surveillance, Epidemiology, and End Results database. Read More

Front Genet 2022 6;13:862803. Epub 2022 Jun 6.

Department of Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Osteosarcoma is a malignant tumor with a poor prognosis. Nowadays, there is a lack of good methods to assess the prognosis of osteosarcoma patients. Transcription co-factors (TcoFs) play crucial roles in transcriptional regulation through the interaction with transcription factors (TFs). Read More

J Bone Oncol 2022 Aug 2;35:100436. Epub 2022 Jun 2.

Department 2 of Orthopedics, The Fifth people's Hospital Of Dalian, NO. 890 Huanghe Street, Shahekou District, Dalian, Liaoning, China.

Background: Circular RNA (circRNA) is a newly-discovered endogenous transcript that has been reported to participate in osteosarcoma (OS) progression. However, the underlying mechanism of circ_0051079 modulating OS development remains unclear.

Methods: RNA expressions of circ_0051079, miR-625-5p and tripartite motif containing 66 (TRIM66) were detected by quantitative real-time polymerase chain reaction. Read More

Biochem Genet 2022 Jun 22. Epub 2022 Jun 22.

Department of Oncology & Vascular Intervention Radiology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, No. 201 HuBinNan Road, Xiamen, 361000, China.

Prior studies have noted the importance of microRNAs (miRNAs) in development and progression of osteosarcoma (OS), but the influence of miR-301b is less investigated. This investigation aimed to explore the biological role of miR-301b/SNX10 in OS. GSE28423 and GSE28424 arrays delivered the corresponding miR-301b and sorting nexin 10 (SNX10) expression levels in OS samples. Read More

Theriogenology 2022 Jun 9;189:70-76. Epub 2022 Jun 9.

Endocrinology-Reproductive Physiology Program and Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Wisconsin, USA. Electronic address:

The present study evaluated expression patterns of chemokine (C-C motif) ligand 2 gene/Monocyte chemoattractant protein-1 gene (CCL2/MCP-1), prostaglandin F2 alpha receptor gene (PTGFR) and immediate early genes including nuclear receptor subfamily 4, group A, member 1 (NR4A1), early growth response 1 (EGR1) and FBJ murine osteosarcoma viral oncogene homolog (FOS) in cells of the bovine corpus luteum after intrauterine infusion of a low dose of prostaglandin F2α (PGF2A) aimed at enhancing our understanding of the mechanisms of luteolysis. Holstein dairy cows were superovulated (>6 corpora lutea [CL]) and on day 9 of the estrous cycle were infused with a low dose of PGF2A (0.5 mg PGF2A in 0. Read More

Eur J Histochem 2022 Jun 22;66(3). Epub 2022 Jun 22.

Orthopedic Center, First People's Hospital of Kashgar, Xinjiang.

Osteosarcoma (OS) is a kind of malignant tumor originating from mesenchymal tissue Bone mesenchymal stem cells-derived extracellular vesicles (BMSCs-EVs) can play important roles in OS. This study investigated the mechanism of BMSCs-EVs on OS. BMSC surface antigens and adipogenic and osteogenic differentiation were detected by flow cytometry, and oil red O and alizarin red staining. Read More

Sci Rep 2022 Jun 21;12(1):10398. Epub 2022 Jun 21.

Department of Orthopedics, The Fifth Hospital of Wuhan/The Second Affiliated Hospital of Jianghan University, Wuhan, 430050, China.

Extensive evidence has explored the involvement of microRNAs (miRNAs) in osteosarcoma (OS). Limitedly, the concrete function of microRNA-18b-5p (miR-18b-5p) in OS remains unexplored and largely elusive. Here, we validated that miR-18b-5p significantly elevated in OS via analyzing the data from GEO database. Read More

Mech Ageing Dev 2022 Jun 18:111689. Epub 2022 Jun 18.

Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy 50134. Electronic address:

Ageing is a complex biological phenomenon representing the major risk factor for developing age-related diseases, such as cardiovascular pathologies, neurodegenerative diseases, and cancer. Geroscience, the new vision of gerontology, identifies cellular senescence as an interconnected biological process that characterises ageing and age-related diseases. Therefore, many strategies have been employed in the last years to reduce the harmful effects of senescence, and among these, the most intriguing ones use nutraceutical compounds. Read More

IEEE J Biomed Health Inform 2022 Jun 21;PP. Epub 2022 Jun 21.

Osteosarcoma is the most common malignant osteosarcoma, and most developing countries face great challenges in the diagnosis due to the lack of medical resources. Magnetic resonance imaging (MRI) has always been an important tool for the detection of osteosarcoma, but it is a time-consuming and labor-intensive task for doctors to manually identify MRI images. It is highly subjective and prone to misdiagnosis. Read More

Clin Cancer Res 2022 Jun 21. Epub 2022 Jun 21.

The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Purpose: Chimeric antigen receptor (CAR) T cell therapy has shown great promise for treating hematologic malignancies but requires a long duration of T-cell expansion, is associated with severe toxicity, and has limited efficacy for treating solid tumors. We designed experiments to address those challenges.

Experimental Design: We generated a cell membrane-anchored and tumor-targeted interleukin-12 (attIL12) to arm peripheral blood mononuclear cells (PBMCs) instead of T cells to omit the expansion phase for required CAR-T cells. Read More

Mini Rev Med Chem 2022 Jun 19. Epub 2022 Jun 19.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.

Melatonin (N-acetyl-5-methoxytryptamine) is a secretory product of the pineal gland. A great number of studies have been investigating the functions of this indoleamine in various diseases. Excessive proliferation, reduction in apoptosis, increased angiogenesis, invasion, and metastasis are all processes associated with cancerous tissues. Read More

Drug Res (Stuttg) 2022 Jun 20. Epub 2022 Jun 20.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Osteosarcoma (OS) patients are commonly treated with chemotherapeutic agents like cisplatin (Cis). Quercetin with fewer side effects can improve the potency of chemotherapy and be used in combinational therapies. Herein, we aimed to evaluate the effects of Cis plus quercetin on DNA damage response (DDR), DNA repair, and apoptosis in Saos-2 cells. Read More

Curr Issues Mol Biol 2021 Dec 22;44(1):46-62. Epub 2021 Dec 22.

Universidad Regional Amazónica Ikiam, Km 7 Via Muyuna, Tena 150150, Ecuador.

The membrane-active nature of phospholipase A-derived peptides makes them potential candidates for antineoplastic and antibacterial therapies. Two short 13-mer C-terminal fragments taken from snake venom Lys49-PLA toxins (p-AppK and p-Acl), differing by a leucine/phenylalanine substitution, were synthesized and their bioactivity was evaluated. Their capacity to interfere with the survival of Gram-positive and Gram-negative bacteria as well as with solid and liquid tumors was assessed in vitro. Read More