33,500 results match your criteria Osteosarcoma


HOXA5 overexpression promotes osteosarcoma cell apoptosis through the p53 and p38α MAPK pathway.

Gene 2018 Dec 3. Epub 2018 Dec 3.

Department of Traumatic Orthopedics, The Second Hospital Affiliated to Lanzhou University, Lanzhou City, Gansu Province 730000, China.

Osteosarcoma is the most common malignant bone tumor in children and adolescents. Aberrant expression of HOXA5 results in various diseases, including cancers. However, the specific function and molecular mechanism of HOXA5 in osteosarcoma is not fully understood. Read More

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December 2018
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[Dedifferentiated diaphyseal juxtacortical osteosarcoma of ulna with metastasis to the lung].

Acta Ortop Mex 2018 May-Jun;32(3):167-171

Departamento de Piel y Partes Blandas del Instituto Nacional de Cancerología. Ciudad de México, México.

Dedifferentiated parosteal osteosarcoma is a variant in which a high grade osteosarcoma coexists with a parosteal osteosarcoma. We report the case of a 20-year-old female patient who presented with six months of evolution of pain and functional limitation of the right forearm, with no apparent cause; radiographs were performed, observing a tumoral lesion in the diaphysis of the right ulna. Physical examination showed pain upon palpation in the diaphysis of the ulna and limitation of prone-supination. Read More

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December 2018
2 Reads

Pain characterization and response to palliative care in dogs with naturally-occurring appendicular osteosarcoma: An open label clinical trial.

PLoS One 2018 6;13(12):e0207200. Epub 2018 Dec 6.

GREPAQ (Groupe de recherche en pharmacologie animale du Québec), Department of biomedical sciences, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, Quebec, Canada.

This study aimed to characterize bone cancer pain (quantitative sensory testing (QST), stance asymmetry index, actimetry, scores of pain and quality of life (QoL)) in dogs with appendicular osteosarcoma (OSA), and to evaluate a stepwise palliative analgesic treatment. The pain profile of thirteen client-owned dogs with OSA was compared with seven healthy dogs. Dogs with OSA were then enrolled in a prospective, open-label, clinical trial. Read More

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December 2018

Norcantharidin inhibits proliferation and promotes apoptosis via c-Met/Akt/mTOR pathway in human osteosarcoma cells.

Cancer Sci 2018 Dec 6. Epub 2018 Dec 6.

Department of Orthopaedics, The Fourth People's Hospital of Shaanxi, Xi'an, 710043, Shaanxi, China.

Osteosarcoma (OS) is the most common malignant bone tumor that frequently affects adolescents. Norcantharidin (NCTD), a demethylated derivative of cantharidin, has been reported exhibits anticancer activity against various types of tumors except human OS. The aims of this study were to evaluate the effects of NCTD on OS cell lines (MG63 and HOS) and to explore the underlying mechanisms. Read More

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December 2018

Metvan, bis(4,7-Dimethyl-1,10-phenanthroline)sulfatooxidovanadium(IV): DFT and Spectroscopic Study-Antitumor Action on Human Bone and Colorectal Cancer Cell Lines.

Biol Trace Elem Res 2018 Dec 5. Epub 2018 Dec 5.

Centro de Química Inorgánica (CEQUINOR/CONICET, CICPBA, UNLP), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Bvd. 120 No. 1465, 1900, La Plata, Argentina.

The complex bis(4,7-dimethyl-1,10-phenantroline)sulfatooxidovanadium(IV), commonly known as Metvan, was prepared using a known synthetic procedure. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for a crystallographic study. The complex was also characterized by a detailed analysis of its infrared spectrum, supported by the theoretical calculations, and also by some data derived from its Raman spectrum. Read More

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December 2018

Cell laden alginate-keratin based composite microcapsules containing bioactive glass for tissue engineering applications.

J Mater Sci Mater Med 2018 Dec 5;29(12):185. Epub 2018 Dec 5.

Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstr.6, 91058, Erlangen, Germany.

Microcapsules based on alginate-keratin, alginate dialdehyde (ADA)-keratin and ADA-keratin-45S5 bioactive glass (BG) were successfully prepared. The samples were characterized by light microscopy, scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The results showed that ADA-based materials possess higher degradation rate compared to alginate-based materials. Read More

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December 2018
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Microsurgical reconstruction with vascularized fibula and massive bone allograft for bone tumors.

Eur J Orthop Surg Traumatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Orthopaedic Surgery, IRCCS Istituto Ortopedico Rizzoli, via Pupilli n1, 40136, Bologna, Italy.

Introduction: Combining massive bone allograft and vascularized fibula in intercalary reconstruction following resection of bone tumors represents a complex reconstructive procedure that requires specialists in microvascular surgery as well as orthopedic surgery. The purpose of our study was to examine the outcomes using this surgical technique in patients with bone tumors in terms of oncologic results, complications related to surgery, Musculoskeletal Tumor Society (MSTS) scores and duration of surgery.

Materials And Methods: We analyzed 81 patients with femoral or tibial sarcomas who underwent intercalary resection and microsurgical reconstruction with massive bone allograft and vascularized fibula. Read More

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December 2018

Down-Regulated microRNA-34a Expression as a Prognostic Marker for Poor Osteosarcoma in Mice: A Systematic Review and Meta-Analysis.

J Cancer 2018 18;9(22):4179-4186. Epub 2018 Oct 18.

Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032China.

In children and adolescents, osteosarcomais the most common malignant bone tumor with a high mortality rate. New therapeutic strategies are urgent to be explored. Studies have proven that microRNAs (miRNAs) in malignant tumors often appear dysregulation, this provides a direction for exploring the new therapeutic strategies for cancers. Read More

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October 2018
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Nomogram application to predict overall and cancer-specific survival in osteosarcoma.

Cancer Manag Res 2018 8;10:5439-5450. Epub 2018 Nov 8.

Department of Orthopedics, Guangzhou First People's Hospital, Guangzhou Medical University, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, People's Republic of China,

Purpose: A prognostic nomogram was applied to predict survival in osteosarcoma patients.

Patients And Methods: Data collected from 2,195 osteosarcoma patients in the Surveillance, Epidemiology, and End Results (SEER) database between 1983 and 2014 were analyzed. Independent prognostic factors were identified via univariate and multivariate Cox analyses. Read More

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November 2018
2 Reads

Calponin-3 is critical for coordinated contractility of actin stress fibers.

Sci Rep 2018 Dec 5;8(1):17670. Epub 2018 Dec 5.

Insitute of Biotechnology, P.O. Box 56, 0014, University of Helsinki, Helsinki, Finland.

Contractile actomyosin bundles, stress fibers, contribute to morphogenesis, migration, and mechanosensing of non-muscle cells. In addition to actin and non-muscle myosin II (NMII), stress fibers contain a large array of proteins that control their assembly, turnover, and contractility. Calponin-3 (Cnn3) is an actin-binding protein that associates with stress fibers. Read More

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December 2018
2 Reads

miR-29 Family Inhibits Resistance to Methotrexate and Promotes Cell Apoptosis by Targeting COL3A1 and MCL1 in Osteosarcoma.

Med Sci Monit 2018 Dec 6;24:8812-8821. Epub 2018 Dec 6.

Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (mainland).

BACKGROUND MicroRNAs (miRNAs) play a crucial role in regulating diverse biological processes, including drug resistance. We investigated the potential roles of the miR-29 family in methotrexate (MTX) resistance in osteosarcoma. MATERIAL AND METHODS Two MTX-resistant osteosarcoma cell lines, MG-63/MTX and U2OS/MTX, were generated by continuous exposure to stepwise increasing concentrations of MTX. Read More

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December 2018
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Carboxypeptidase E-ΔN promotes migration, invasion and epithelial-mesenchymal transition of human osteosarcoma cell lines through the Wnt/β-catenin pathway.

Biochem Cell Biol 2018 Dec 3. Epub 2018 Dec 3.

The First Affiliated hospital of China Medical University, Department of Orthopedic Surgery, Shenyang, China ;

Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents, and metastatic OS is the major cause of OS-related death. Carboxypeptidase E (CPE) is demonstrated to be highly expressed in some cancer types, and its N-terminal truncated form, CPE-ΔN, is implicated in tumor metastasis and poor prognosis. In this study, we investigated the effect of CPE-ΔN on cell migration, invasion and epithelial-mesenchymal transition (EMT) of OS cells, and illustrated the molecular mechanisms. Read More

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December 2018
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Metformin induces CD11b+ cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and antitumor effects.

Int Immunol 2018 Dec 2. Epub 2018 Dec 2.

Department of Immunology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

CD11b+ myeloid subpopulations, including myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs), play crucial roles in the suppression of T-cell-mediated antitumor immunity. Regulation of these cell types is a primary goal for achieving efficient cancer immunotherapy. We found that metformin (Met) induces CD11b+ cell-mediated growth inhibition of a K7M2neo osteosarcoma independent of T cells, as growth inhibition of K7M2neo was still observed in wild type (WT) mice depleted of T cells by antibodies and in SCID; this contrasted with the effect of Met on Meth-A fibrosarcoma, which was entirely T cell-dependent. Read More

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December 2018
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Targeting the centrosome and polo-like kinase 4 in osteosarcoma.

Carcinogenesis 2018 Dec 2. Epub 2018 Dec 2.

Department of Medical Oncology Peter MacCallum Cancer Center, Melbourne VIC, Australia.

It has been historically uncertain if extra centrosomes are a cause or consequence of tumorigenesis. Experiments have recently established that overexpression of polo-like kinase 4 (PLK4) promotes centrosome amplification with consequential promotion of cellular aneuploidy. Furthermore, centrosome amplification drives spontaneous tumorigenesis in mice. Read More

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December 2018

Microvesicles derived from human bone marrow mesenchymal stem cells promote U2OS cell growth under hypoxia: the role of PI3K/AKT and HIF-1α.

Hum Cell 2018 Nov 30. Epub 2018 Nov 30.

Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.

Studies have demonstrated that mesenchymal stem cells (MSCs) can promote tumor growth, and MSC microvesicles (MVs) are very important in the tumor microenvironment and information transfer between cells during tumorigenesis and development. However, the potential effects and mechanisms of MSC-MVs on tumor growth are still controversial. Here in this study, we investigated the roles and effects of human bone marrow MSC-MVs (hBMSC-MVs) on human osteosarcoma (U2OS) cell growth under hypoxia in vitro and in vivo. Read More

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November 2018

Plasma processing of PDMS based spinal implants for covalent protein immobilization, cell attachment and spreading.

J Mater Sci Mater Med 2018 Nov 30;29(12):178. Epub 2018 Nov 30.

School of Physics, University of Sydney, Sydney, NSW, 2006, Australia.

PDMS is widely used for prosthetic device manufacture. Conventional ion implantation is not a suitable treatment to enhance the biocompatibility of poly dimethyl siloxane (PDMS) due to its propensity to generate a brittle silicon oxide surface layer which cracks and delaminates. To overcome this limitation, we have developed new plasma based processes to balance the etching of carbon with implantation of carbon from the plasma source. Read More

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November 2018

Targeting CD44 by CRISPR-Cas9 in Multi-Drug Resistant Osteosarcoma Cells.

Cell Physiol Biochem 2018 Nov 30;51(4):1879-1893. Epub 2018 Nov 30.

Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, China.

Background/aims: Drug resistance is the main difficulty for the current treatment for osteosarcoma. Cluster of differentiation 44 (CD44) is a receptor for hyaluronic acid (HA) and HA-binding has been proven to participate in various biological tumor activities, including tumor progression, metastasis and drug resistance. In this study, we aimed to determine the effects of CD44 on migration, invasion, proliferation, and the drug-sensitivity of osteosarcoma. Read More

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November 2018
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Global Analysis of Osteosarcoma Lipidomes Reveal Altered Lipid Profiles in Metastatic vs. Non-Metastatic Cells.

J Lipid Res 2018 Nov 30. Epub 2018 Nov 30.

University of Illinois,Urbana-Champaign, United States

Osteosarcoma (OS) is the most common form of primary bone cancer in humans. The early detection and subsequent control of metastasis has been challenging in OS. Lipids are important constituents of cells that maintaining structural integrity that can be converted into lipid signaling molecules and are reprogrammed in cancerous states. Read More

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November 2018

Radiographic Assessment of the Popliteal Lymph Node to Aid the Differentiation of Canine Stifle Osteosarcoma From Moderate to Severe Stifle Degenerative Joint Disease.

Top Companion Anim Med 2018 Dec 20;33(4):136-140. Epub 2018 Aug 20.

Department of Veterinary Clinical Sciences, Ohio State University College of Veterinary Medicine, Columbus, OH, USA. Electronic address:

Degenerative joint disease of the stifle is a common canine osseous pathology. Early degenerative changes may show mild mineral proliferation of periarticular margins with soft tissue, resulting in joint distension. If the joint is chronically unstable, osseous changes become more complex. Read More

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December 2018

Analysis of the transcriptome data in Litopenaeus vannamei reveals the immune basis and predicts the hub regulation-genes in response to high-pH stress.

PLoS One 2018 5;13(12):e0207771. Epub 2018 Dec 5.

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology (LMB), Guangdong Provincial Key Laboratory of Applied Marine Biology (LAMB), South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.

Soil salinization erodes the farmlands and poses a serious threat to human life, reuse of the saline-alkali lands as cultivated resources becomes increasingly prominent. Pacific white shrimp (Litopenaeus vannamei) is an important farmed aquatic species for the development and utilization of the saline-alkali areas. However, little is known about the adaptation mechanism of this species in terms of high-pH stress. Read More

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December 2018
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Unusual Focal Muscle FDG Activity Related to Altered Biomechanics.

Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.

A 20 year old man suffered severe right knee pain, especially when his right foot touched ground. The MRI findings suggested periosteal osteosarcoma, which led to a staging FDG PET/CT. The images showed not only a hypermetabolic right knee lesion but also focally elevated activity in select muscles, which was attributed to altered biomechanics. Read More

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December 2018

Loss of miR-198 and -206 during primary tumor progression enables metastatic dissemination in human osteosarcoma.

Oncotarget 2018 Nov 6;9(87):35726-35741. Epub 2018 Nov 6.

INSERM, UMR-S 1238, Nantes 44035, France.

The metastatic dissemination is a complex multistep process by which tumor cells from a primary site enter into the systemic circulation to finally spread at distant sites. Even if this mechanism is rare at the tumor level, it remains the major cause of Osteosarcoma-patients' relapse and mortality. MicroRNAs (miRNAs) have recently been described as novel epigenetics' genes' expression regulators actively implicated in cancer progression and dissemination. Read More

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November 2018
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CircFAT1 sponges miR-375 to promote the expression of Yes-associated protein 1 in osteosarcoma cells.

Mol Cancer 2018 Dec 4;17(1):170. Epub 2018 Dec 4.

Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang Province, China.

Background: There is an urgent need to identify new molecular targets for treatment of osteosarcoma. Circular RNAs are a class of endogenous RNAs that are extensively found in mammalian cells and exert critical functions in the regulation of gene expression, but in osteosarcoma the underlying molecular mechanism of circular RNAs remain poorly understood. Here we assessed the tumorigenesis properties of a circular RNA, circFAT1 in osteosarcoma. Read More

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December 2018

Chromosome instability in tumor cells due to defects in Aurora B mediated error correction at kinetochores.

Cell Cycle 2018 Dec 4. Epub 2018 Dec 4.

a Cancer Biology Program , Philadelphia , PA 19111 , USA.

We characterized a panel of cancer cells and found that they exhibited chromosome instability (CIN) that was associated with high frequencies of aberrant kinetochore:microtubule attachments. Failure to resolve these defective attachments before anaphase onset can lead to missegregation of chromosomes. Aurora B kinase is concentrated at the inner centromere where it contributes to multiple kinetochore functions, one of which is in error-correction. Read More

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December 2018

Erratum: CircRNA CDR1as/miR-7 signals promote tumor growth of osteosarcoma with a potential therapeutic and diagnostic value [Corrigendum].

Authors:

Cancer Manag Res 2018 16;10:5867. Epub 2018 Nov 16.

[This corrects the article on p. 4871 in vol. 10, PMID: 30425578. Read More

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November 2018

Fracture-associated osteosarcoma of the femur in a cat.

Can Vet J 2018 Oct;59(10):1096-1098

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32608, USA.

This report describes a domestic shorthair cat with fracture-associated osteosarcoma 11 years after injury. A left hind limb amputation was performed using coxofemoral disarticulation. No intravenous cytotoxic chemotherapy was used after surgery. Read More

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October 2018
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HDAC2 depletion promotes osteosarcoma's stemness both in vitro and in vivo: a study on a putative new target for CSCs directed therapy.

J Exp Clin Cancer Res 2018 Dec 3;37(1):296. Epub 2018 Dec 3.

Dipartimento di Medicina Sperimentale, Sezione di Biotecnologie, Istologia Medica e Biologia Molecolare, Università degli Studi della Campania "L. Vanvitelli", Napoli, via L. Armanni, 5, 80138, Naples, Italy.

Background: Cancer stem cells (CSCs) play a key role in cancer initiation, progression and chemoresistance. Epigenetic alterations have been identified as prominent factors that contribute to the CSCs phenotype. Here, we investigated the effects of the HDAC inhibitor valproic acid (VPA) and the demethylating agent, 5'azacytidine (DAC) on the stem phenotype of MG63 and Saos2 osteosarcoma cell lines. Read More

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December 2018

Gastrointestinal Malignancy Presenting with a Virchow's Node in a Patient with Rothmund-Thomson Syndrome.

Case Rep Genet 2018 25;2018:7536832. Epub 2018 Oct 25.

Department of General Surgery, Northern Ontario School of Medicine, Sudbury, Ontario, Canada.

Rothmund-Thomson syndrome is a genetic disorder with characteristic findings in childhood as well as a predisposition to osteosarcoma, skin cancer, and hematological malignancy. We present the first reported case of duodenal malignancy in a patient with Rothmund-Thompson syndrome. An enlarged Virchow's node was noted and an advanced duodenal adenocarcinoma was diagnosed shortly thereafter. Read More

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October 2018

Maternally expressed, paternally imprinted, embryonic non-coding RNA are expressed in osteosarcoma, Ewing sarcoma and spindle cell sarcoma.

Pathology 2018 Nov 26. Epub 2018 Nov 26.

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom; Department of Clinical Biochemistry, Norfolk and Norwich University Hospital, Norwich Research Park, Norwich, United Kingdom. Electronic address:

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November 2018

Assessment of metabolic patterns and new antitumoral treatment in osteosarcoma xenograft models by [F]FDG and sodium [F]fluoride PET.

BMC Cancer 2018 Nov 29;18(1):1193. Epub 2018 Nov 29.

Servicio de Medicina Nuclear, Clínica Universidad de Navarra, Avenida Pío XII, 36 31008, Pamplona, Spain.

Background: Osteosarcoma is the most common malignant bone tumor in children and young adults that produces aberrant osteoid. The aim of this study was to assess the utility of 2-deoxy-2-[18F-] fluoro-D-glucose ([F] FDG) and sodium [F] Fluoride (Na [F] F) PET scans in orthotopic murine models of osteosarcoma to describe the metabolic pattern of the tumors, to detect and diagnose tumors and to evaluate the efficacy of a new treatment based in oncolytic adenoviruses.

Methods: Orthotopic osteosarcoma murine models were created by the injection of 143B and 531MII cell lines. Read More

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November 2018
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Comparison of clinical features, management and outcomes of osteosarcoma located in proximal fibula and proximal tibia: a propensity score matching analysis.

BMC Cancer 2018 Nov 29;18(1):1195. Epub 2018 Nov 29.

Department of Musculoskeletal Oncology Center, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan 2nd Rd, Guangzhou, 510080, China.

Background: The aim of this study was to compare proximal fibular and proximal tibial sites regarding osteosarcoma in the proximal crus. Furthermore, we proposed a hypothesis explaining the differences.

Methods: From Jaunary 2000 to February 2015, 28 patients with non-metastatic proximal fibular osteosarcoma and 214 patients with non-metastatic proximal tibial osteosarcoma underwent surgery were identified in our center. Read More

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November 2018

Upregulation of long non-coding RNA NNT-AS1 promotes osteosarcoma progression by inhibiting the tumor suppressive miR-320a.

Cancer Biol Ther 2018 Nov 29:1-10. Epub 2018 Nov 29.

d Department of Orthopedics , Affiliated Hospital of Qingdao University , Shandong , China.

Objective: To investigate the role and mechanism of action of nicotinamide nucleotide transhydrogenase antisense RNA 1 (NNT-AS1) in osteosarcoma (OS).

Methods: Bioinformatic analysis suggested miR-320a as potential target of NNT-AS1. Influence of NNT-AS1 overexpression or knockdown on OS cell proliferation, colony-formation, apoptosis, migration and invasion capacity was first investigated. Read More

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November 2018

The chemical composition and events related to the cytotoxic effects of propolis on osteosarcoma cells: A comparative assessment of Colombian samples.

Phytother Res 2018 Nov 28. Epub 2018 Nov 28.

Institute of Biosciences, São Paulo State University (UNESP), Campus Botucatu, Brazil.

Osteosarcoma (OSA) is a type of bone cancer showing an aggressive biological behavior with metastatic progression. Because propolis potential for the development of new antitumoral drugs has been indicated, we evaluated the chemical composition of Colombian propolis samples and the mechanisms involved in their cytotoxic effects on OSA cells. The chemical composition was analyzed by GC-MS and the DPPH free radical scavenging activity was measured. Read More

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November 2018
2 Reads

Extra Skeletal Ewing's Sarcoma Involving Perineum of a Young Male Patient.

Mymensingh Med J 2018 Oct;27(4):879-882

Dr Md Ahsan Habib, Assistant Professor Department of Oncosurgery, National Institute of Cancer Research & Hospital, Mohakhali, Dhaka, Bangladesh; E-mail: drahsanhabib1306

Ewing's Sarcoma is the second most common primary malignant bone tumor in children and young adults after osteosarcoma but exceptionally it can arise from extra skeletal sites also. Extra skeletal Ewing's sarcoma is of neuroectodermal origin and usually involves extremities, retroperitoneum and paravertebral regions. No case of extra skeletal Ewing's sarcoma involving perineum is yet reported. Read More

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October 2018

Development and In Vitro Evaluation of Linear PEI-Shelled Heparin/Berberine Nanoparticles in Human Osteosarcoma U-2 OS Cells.

Molecules 2018 Nov 28;23(12). Epub 2018 Nov 28.

Department of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan.

Berberine (BBR), a natural isoquinoline alkaloid derived from Chinese herbs, exerts many biological effects, including antiviral, antimicrobial, antidiarrhea, anti-inflammatory, and antitumor effects. In this study, a novel berberine nanoparticle (NP) consisting of heparin (HP) and BBR with or without being shelled with linear polyethyleneimine (LPEI) was developed to enhance its antitumor activity on osteosarcoma U-2 OS cells. With varying ratios of HP to BBR, HP/BBR NPs had a size ranging from 218. Read More

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November 2018

lncRNA nuclear-enriched abundant transcript 1 promotes cell proliferation and invasion by targeting miR-186-5p/HIF-1α in osteosarcoma.

J Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.

Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Increasing evidence shows that the long noncoding RNA nuclear enriched abundant transcript 1 (NEAT1) plays important roles in tumor progression. However, the function and the underlying mechanism of NEAT1 in osteosarcoma (OS) remain unclear. In the present study, we found that NEAT1 expression was significantly upregulated in OS tissues and cell lines. Read More

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November 2018
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MicroRNA-338-3p inhibits tumor growth and metastasis in osteosarcoma cells by targeting RUNX2/CDK4 and inhibition of MAPK pathway.

J Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.

Department of Orthopedics, Ping An (Hefei) Internet Hospital, Hefei, China.

Osteosarcoma (OS) is one of the most aggressive bone tumors. MicroRNAs (miRNAs) have been found to implicate in the pathogenesis of different types of cancers, including OS. This study aimed to explore the roles of miR-338-3p in OS and investigate the underlying mechanism. Read More

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November 2018

Chinese Herbal Medicine for Osteosarcoma in the Mouse: A Systematic Review and Meta-Analysis.

Chin J Integr Med 2018 Nov 27. Epub 2018 Nov 27.

Orthopedic Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

Objective: To summarize and critically assess the inhibitory effects of Chinese herbal medicine (CHM) on tumor volume and tumor weight for the treatment of osteosarcoma (OS) in mouse models.

Methods: PubMed, Embase, Web of Science, China Knowledge Resource Integrated Database (CNKI), Wanfang Database, VIP Database, and Chinese BioMedical (CBM) were searched since their inception dates to March 10, 2016. Two reviewers independently selected the controlled studies estimating effects of CHM on mouse OS by administration in vivo. Read More

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November 2018
2 Reads

Evaluation of tumor-infiltrating lymphocytes in osteosarcomas of the jaws: a multicenter study.

Virchows Arch 2018 Nov 27. Epub 2018 Nov 27.

Department of Stomatology (Oral Pathology), School of Dentistry, Universidade Federal de Goiás, Goiânia, GO, Brazil.

The aim of the present study was to investigate the profile of tumor-infiltrating lymphocytes (TIL) in osteosarcomas of the jaws (OSJ). A total of 21 OSJ samples were analyzed in a retrospective and cross-sectional multicenter study. Immunohistochemistry was performed to determine the recognition of TIL such as CD4, CD8, granzyme B (GrB), programmed cell death protein (PD-1), and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) in intratumoral and peripheral (stromal) regions. Read More

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November 2018
4 Reads

FOXN3 is downregulated in osteosarcoma and transcriptionally regulates SIRT6, and suppresses migration and invasion in osteosarcoma.

Oncol Rep 2018 Nov 21. Epub 2018 Nov 21.

Department of Orthopedics, Qingdao Central Hospital, Qingdao, Shandong 266042, P.R. China.

Forkhead box N3 (FOXN3) has been reported to be downregulated in numerous cancers, including laryngeal, oral squamous cell and hepatocellular carcinomas, and diffuse large B‑cell lymphoma. FOXN3 was proposed to serve as a tumor suppressor; however, the function of FOXN3 in osteosarcoma (OS) remains unknown. The present study suggested that FOXN3 was notably downregulated in OS tissues compared with in adjacent normal tissues, and the expression of FOXN3 was negatively correlated with tumor size, metastasis and tumor, node and metastasis stage. Read More

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November 2018
2 Reads

SLC25A22 Promotes Proliferation and Metastasis of Osteosarcoma Cells via the PTEN Signaling Pathway.

Technol Cancer Res Treat 2018 Jan;17:1533033818811143

1 Orthopedics department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan province, China.

Osteosarcoma is a highly malignant bone tumor. However, due to the high complexity of the occurrence and metastasis of osteosarcoma, the exact mechanism promoting its development and progression remains to be elucidated. This study highlights the causal link between solute carrier family 25 member 22 (SLC25A22) and the development, progression, and metastasis of osteosarcoma. Read More

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January 2018

Long Noncoding RNA FER1L4 Suppresses Tumorigenesis by Regulating the Expression of PTEN Targeting miR-18a-5p in Osteosarcoma.

Cell Physiol Biochem 2018 Nov 27;51(3):1364-1375. Epub 2018 Nov 27.

Department of Neurosurgery, the First Hospital of Jilin University, Changchun, China.

Background/aims: Novel long non-coding RNA Fer-1-like protein 4 (FER1L4) has been reported to play crucial regulatory roles in tumor progression. However, its clinical significance and biological role in osteosarcoma (OS) is completely unknown. The aim of the present study was to investigate the role of FER1L4 in OS progression and the underlying mechanism. Read More

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November 2018
2 Reads

Long Non-Coding RNA Urothelial Carcinoma Associated 1 Promotes Proliferation, Migration and Invasion of Osteosarcoma Cells by Regulating microRNA-182.

Cell Physiol Biochem 2018 Nov 27;51(3):1149-1163. Epub 2018 Nov 27.

Department of Hand Surgery, China-Japan Union Hospital of Jilin University, Changchun,

Background/aims: Previous studies demonstrated the oncogenic roles of lncRNA UCA1 in osteosarcoma. This study aimed to explore the internal molecular mechanism of UCA1 on promoting osteosarcoma cell proliferation, migration and invasion.

Methods: qRT-PCR was conducted to measure the expression levels of UCA1, miR-182 and TIMP2. Read More

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November 2018
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LncRNA MALAT1 Promotes Cancer Metastasis in Osteosarcoma via Activation of the PI3K-Akt Signaling Pathway.

Cell Physiol Biochem 2018 Nov 27;51(3):1313-1326. Epub 2018 Nov 27.

Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer, Shanghai, China.

Background/aims: LncRNAs have been reported to be vital regulators of the progression of osteosarcoma, although the underlying mechanisms are not completely understood.

Methods: The levels of MALAT1 and miR-129-5p expression were measured using qRT-PCR. Cell growth was determined using the CCK-8 and colony formation assays. Read More

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November 2018
4 Reads

Preparation of adriamycin gelatin microsphere-loaded decellularized periosteum that is cytotoxic to human osteosarcoma cells.

J Cell Physiol 2018 Nov 27. Epub 2018 Nov 27.

Department of Hand Surgery, Ningbo No. 6 Hospital, Ningbo, China.

The purpose of this study was to develop a novel approach to treat bone osteosarcoma using a multipurpose scaffold aiming for local drug delivery. The slowly releasing microspheres was designed to deliver the chemotherapy drug adriamycin (ADM) and a decellularized (D) periosteum scaffold (which is known to be able to promote bone regeneration) was used to carry these microspheres. D-periosteum was obtained by physical and chemical decellularization. Read More

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November 2018
5 Reads

Topographical Features of Graphene-Oxide-Functionalized Substrates Modulate Cancer and Healthy Cell Adhesion Based on the Cell Tissue of Origin.

ACS Appl Mater Interfaces 2018 Nov 27. Epub 2018 Nov 27.

Department of Informatics, Bioengineering, Robotics and Systems Engineering , University of Genova , Via all' Opera Pia 13 , Genoa 16145 , Italy.

Graphene-derived materials, such as graphene oxide (GO), have been widely explored for biomedical and biological applications, including cancer research. Despite some recent works proving that GO inhibits the migration and invasion of different cancer cells, so far most of these in vitro studies have been conducted using GO sheets dispersed in solution or as a planar film. On the contrary, little is known about cellular activities, such as cell viability, adhesion, and spreading, when cancer cells interface with GO functionalized hydrogel-based surfaces, biomechanically and structurally more similar to the tumor environment. Read More

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November 2018
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Metastatic osteosarcoma challenged by regorafenib.

Lancet Oncol 2018 Nov 23. Epub 2018 Nov 23.

Institut de Cancérologie de l'Ouest, INSERM, CRCINA, UMR 1232, Université de Nantes, Université d'Angers, 44805 Saint-Herblain, France; Department of Oncology and Metabolism, INSERM, European Associated Laboratory Sarcoma Research Unit, Medical School, University of Sheffield, Sheffield, UK. Electronic address:

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November 2018

Efficacy and safety of regorafenib in adult patients with metastatic osteosarcoma: a non-comparative, randomised, double-blind, placebo-controlled, phase 2 study.

Lancet Oncol 2018 Nov 23. Epub 2018 Nov 23.

Medical Oncology Department, Centre Léon Bérard, Lyon, France.

Background: Regorafenib has proven activity in patients with pretreated gastrointestinal stromal tumours and colorectal and hepatocellular carcinoma. We designed REGOBONE to assess the efficacy and safety of regorafenib for patients with progressive metastatic osteosarcoma and other bone sarcomas. This trial comprised four parallel independent cohorts: osteosarcoma, Ewing sarcoma, chondrosarcoma, and chordoma. Read More

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November 2018
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An evaluation of TAZ and YAP crosstalk with TGFβ signalling in canine osteosarcoma suggests involvement of hippo signalling in disease progression.

BMC Vet Res 2018 Nov 26;14(1):365. Epub 2018 Nov 26.

Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada.

Background: Osteosarcoma (OSA) is the most common bone cancer in canines. Both transforming growth factor beta (TGFβ) and Hippo pathway mediators have important roles in bone development, stemness, and cancer progression. The role of Hippo signalling effectors TAZ and YAP has never been addressed in canine OSA. Read More

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November 2018
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