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Oral Oncol 2018 Dec 13;87:177-178. Epub 2018 Nov 13.

Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, India.

Oral Oncol 2018 Dec 2;87:126-130. Epub 2018 Nov 2.

Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam, Department of Oral and Maxillofacial Surgery/Oral Pathology, De Boelelaan 1117, Amsterdam, the Netherlands. Electronic address:

Objectives: Hypovascularisation is thought to play an important role in the pathogenesis of osteoradionecrosis. The objective of this study was to assess the microvascular system in the irradiated mandibular bone marrow.

Materials And Methods: Mandibular bone biopsies were taken from 20 irradiated patients and 24 controls. Read More

Cancers (Basel) 2018 Dec 4;10(12). Epub 2018 Dec 4.

Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

Background: Adenoid cystic carcinoma (ACC) are more common in the minor salivary glands (MiSGs) than the major salivary glands, and are characterized by slow tumor progression and frequently local recurrence. The main treatment option is surgery followed by combined radiotherapy.

Methods: A retrospective analysis contained 67 patients with ACC of MiSGs in the oral cavity who underwent surgery followed by radiotherapy. Read More

J Oral Pathol Med 2018 Dec 1. Epub 2018 Dec 1.

Department of Oral and Maxillofacial Surgery, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510655, China.

Objective: We have previously demonstrated the effect of alpha-2-macroglobulin (α2M) in the remediation of radiation-induced cellular damage. Here, we investigated the protective effects of α2M in a preclinical rat model of jaw osteoradionecrosis (ORN).

Methods: Eighteen rats were divided randomly into three groups: the control group, the radiation therapy (RT) alone group, and the radiated mandibles pretreated with α2M (α2M + RT) group. Read More

Diving Hyperb Med 2018 Dec;48(4):229-234

Department of Diving and Hyperbaric Medicine, Prince of Wales Hospital, Sydney, Australia.

Background: Nutritional assessment and support is essential for wound management. The hyperbaric oxygen clinic is a unique outpatient service where chronically unwell patients present daily for hyperbaric oxygen treatment (HBOT) over several weeks, allowing time for effective nutritional intervention. This is the first study to examine the prevalence of those at risk of malnutrition in a cohort of hyperbaric medical patients. Read More

Oral Radiol 2018 Sep 4;34(3):224-228. Epub 2017 Sep 4.

Department of Radiology, The Nippon Dental University Niigata Hospital, 1-8 Hamaura-cho, Chuo-ku, Niigata, Niigata, 951-8580, Japan.

Objectives: The aim of this study was to investigate the usefulness of diffusion-weighted magnetic resonance imaging (DWI) in oral and maxillofacial lesions, especially the utility of apparent diffusion coefficient (ADC) maps for differential diagnosis of these lesions.

Methods: Fifty-seven patients who underwent magnetic resonance imaging for diagnosis of oral and maxillofacial lesions were included in this prospective study. DWI was performed on a 1. Read More

Laryngoscope 2018 Nov 19. Epub 2018 Nov 19.

SUNY Downstate Medical Center, New York, New York, U.S.A.

Objectives: Adequate treatment of laryngopharyngeal malignancy often incorporates radiation therapy. Structures surrounding laryngopharynx exposed to traditional radiation doses are susceptible to posttreatment toxicity. Among poorly understood sequelae is the rare manifestation of sternoclavicular joint (SCJ) osteoradionecrosis (ORN). Read More

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Nov 14. Epub 2018 Nov 14.

Service d'oto-rhino-laryngologie et de chirurgie cervicofaciale, université Pierre-et-Marie-Curie, Paris VI, Hôpital Tenon, Assistance-Publique-Hôpitaux de Paris, 4, rue de la Chine, 75020 Paris, France.

Objectives: Osteoradionecrosis (ORN) of the mandible is a common complication of head and neck radiotherapy and often requires surgical treatment. Squamous cell carcinoma (SCC) can be exceptionally discovered within zones of ORN on histological examination of the operative specimen. The authors discuss the management of these lesions based on a short patient series. Read More

Int J Clin Oncol 2018 Nov 9. Epub 2018 Nov 9.

Department of Otolaryngology, Eye Ear Nose and Throat Hospital, Shanghai Medical College, Fudan University, 83 Fenyang Road, Shanghai, People's Republic of China.

Background: Skull base osteoradionecrosis is a devastating post-irradiation complication in nasopharyngeal carcinoma patients. We conducted a retrospective analysis to assess the long-term survival and prognostic factors of patients with skull base osteoradionecrosis treated with endoscopic sequestrectomy.

Methods: We enrolled 59 nasopharyngeal carcinoma patients with skull base osteoradionecrosis who underwent endoscopic nasopharyngectomy. Read More

J Prosthet Dent 2018 Nov 1. Epub 2018 Nov 1.

Maxillofacial Prosthetics Director, Dental Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

For patients with head and neck cancer requiring a maxillectomy, obturator prostheses help with quality of life. These patients routinely require adjuvant oncologic treatments with significant adverse effects. Treatment sequelae can leave patients with difficulty speaking and swallowing, reduced salivary function, reduction in maximal incisal opening, and at risk of osteoradionecrosis. Read More

Adv Radiat Oncol 2018 Oct-Dec;3(4):701-704. Epub 2018 Jun 4.

Department of Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York.

Maxillofac Plast Reconstr Surg 2018 Dec 4;40(1):25. Epub 2018 Oct 4.

Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry, 50-1, Yonsei-ro, Seodaemoon-gu, Seoul, 03722 Republic of Korea.

Background: Some of head and neck cancer patients are in compromised general condition after ablation surgery and chemoradiation therapy, which makes secondary free tissue transfer quite challenging. Elderly cancer patients also have some risk for microvascular surgery with lengthened general anesthesia. In those cases, the pedicled flap vascularized by supraclavicular artery could be considered as an alternative to free flap. Read More

Med Oral Patol Oral Cir Bucal 2018 Nov 1;23(6):e633-e638. Epub 2018 Nov 1.

School of Dentistry, Federal University of Minas Gerais, Department of Clinical, Pathology and Surgery, Presidente Antônio Carlos, 6627 - 31270-901- Pampulha Belo Horizonte - MG, Brazil,

Background: Osteoradionecrosis (ORN) is one of the most serious complications of head and neck radiotherapy and is considered a public health problem worldwide. This study aims to determine the prevalence and associated factors of ORN in patients undergoing radiotherapy for head and neck malignancy.

Material And Methods: A cross-sectional retrospective study was conducted, in which all medical records of patients undergoing head and neck radiation in the period between 2006 to 2015 (10 years) were examined. Read More

JAMA Otolaryngol Head Neck Surg 2018 Oct;144(10):913-922

HealthCore, Wilmington, Delaware.

Importance: Definitive radiotherapy (RT) and primary surgery (PS) are considered to be equally viable local therapy modalities for oropharyngeal squamous cell carcinoma (OPSCC). The comparative effectiveness of these therapies is often debated, and treatment decisions are based on a paucity of comparative data.

Objective: To examine the differences in overall survival and key toxic effects in patients with OPSCC treated with RT and PS. Read More

Biores Open Access 2018 8;7(1):145-149. Epub 2018 Oct 8.

Hospital Hyperbaric Oxygen Therapy Unit, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Osteoradionecrosis (ORN) is a common consequence resulting from radiation in patients with cancer. Presently, hyperbaric oxygen therapy (HBOT) is proposed to have a role in improving wound healing in ORN patients. There is no strong scientific evidence to confirm the benefits of HBOT for treatment of ORN as an adjunctive treatment. Read More

Rev Med Interne 2018 Oct 6. Epub 2018 Oct 6.

Unité de lymphologie, site constitutif du Centre national de référence des maladies vasculaires rares (lymphœdèmes primaires), hôpital Cognacq-Jay, 15, rue Eugène Millon, 75015 Paris, France.

Br J Oral Maxillofac Surg 2018 Nov 29;56(9):897-898. Epub 2018 Sep 29.

Maxillofacial/Head & Neck Fellow, OMFS Dept, Leeds Teaching Hospitals NHS Trust. Electronic address:

J Craniomaxillofac Surg 2018 Nov 24;46(11):1960-1967. Epub 2018 Aug 24.

Department of Oral Maxillofacial & Head and Neck Oncology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Zhi-zao-ju Rd, No. 639, Shanghai, 200011, China. Electronic address:

Purpose: Osteoradionecrosis of the mandible (ORNM) is one of the most devastating complications following radiotherapy. Postoperative relapse (POR) occurs with high incidence even if a radical resection is performed. The current investigation was designed to identify prognostic factors for POR and to establish a nomogram model to estimate the risk for the onset of POR of ORNM. Read More

Mol Med Rep 2018 Nov 4;18(5):4219-4228. Epub 2018 Sep 4.

Department of Oral and Maxillofacial Surgery, The Sixth Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510655, P.R. China.

Osteoradionecrosis of the jaws (ORNJ) is a complication of oral and maxillofacial malignancy that arises following radiotherapy; progressive jaw necrosis severely decreases the quality of life of patients. Human bone marrow mesenchymal stem cells (hBMMSCs) are a cell type with self‑renewal and pluripotent differentiation potential in the bone marrow stroma. These cells are associated with bone tissue regeneration and are one of the primary cell types affected by bone tissue radiation injury. Read More

Int J Oral Maxillofac Surg 2018 Sep 8. Epub 2018 Sep 8.

Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, USA.

Osteoradionecrosis (ORN) of the jaws remains among the most commonly encountered and challenging complications of radiotherapy to the head and neck. The purpose of this study was to provide a review of the medical management for ORN and evaluate the reported outcomes with the use of pentoxifylline and tocopherol (PENTO), by means of a systematic review and meta-analysis. The predictor variable was the use of PENTO in the treatment of ORN. Read More

Med Oral Patol Oral Cir Bucal 2018 Sep 1;23(5):e524-e530. Epub 2018 Sep 1.

Universidade Federal de Uberlândia, Faculdade de Odontologia, Av. Pará, 1720, Bloco 4L, Anexo A, Campos Umuarama, CEP: 38400-902, Uberlândia, Minas Gerais, Brazil,

Background: To review and discuss important topics regarding periodontal treatment pre- and post-radiotherapy for head and neck cancer in human patients; to discuss the references for adequate techniques, the appropriate moment for tooth extractions and periodontal management; and to discuss the prevention of osteoradionecrosis.

Material And Methods: Thirty-nine studies including original studies, randomized clinical trials (RCTs) and reviews were searched in online databases MEDLINE (PubMed) and the Cochrane library. No year of publication restriction was applied. Read More

Korean J Thorac Cardiovasc Surg 2018 Aug 5;51(4):273-276. Epub 2018 Aug 5.

Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital.

We report the rare case of a 58-year-old woman who was diagnosed with fungal empyema thoracis combined with osteoradionecrosis. After 32 months of home care followed by open window thoracostomy, thoracoplasty with serratus anterior muscle transposition and a latissimus dorsi myocutaneous flap was performed successfully. Although thoracoplasty is now rarely indicated, it is still the treatment of choice for the complete obliteration of thoracic spaces. Read More

Otol Neurotol 2018 Oct;39(9):1172-1183

Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine.

Objectives: To perform a systematic review evaluating etiologies, associated complications, and management of osteoradionecrosis of the temporal bone (ORNTB).

Methods: The authors searched the PubMed, Embase, and Cochrane Library databases for relevant literature. Patient demographics, etiologies, treatments, and other clinical characteristics were obtained. Read More

Rep Pract Oncol Radiother 2018 Jul-Aug;23(4):270-275. Epub 2018 Jul 26.

Department of Radiation Oncology, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada.

Aim: To develop a tool in order to guide pre-irradiation dental care (PIDC) for patients with oropharyngeal cancers.

Background: Osteoradionecrosis of the jaws is a potential complication of radiotherapy (RT) for head and neck cancers. To prevent this complication, PIDC can involve multiple dental extractions as a preventative measure to avoid post-RT complications. Read More

J Prosthodont Res 2018 Oct 3;62(4):518-521. Epub 2018 Aug 3.

Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.

Patients: Seventy-one and 73 years-old males visited a perioperative oral care support center to receive perioperative oral management during tongue cancer (TNM) treatment. To improve their quality of life (QOL) during brachytherapy while preventing radiation-related complications including osteoradionecrosis due to Au grain brachytherapy, spacers for their maxilla and mandible were designed with consideration of wearing condition at an isolation ward. The spacer was created with unilateral design and with consideration of the tongue mobility during day and night. Read More

Int Forum Allergy Rhinol 2018 Dec 2;8(12):1454-1458. Epub 2018 Aug 2.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

Background: Reconstruction of the clivus and posterior cranial base defects following endoscopic skull-base surgery can be particularly challenging. Commonly, defects in this region are repaired with pedicled mucoperichondrial flaps from the sinonasal cavity. Complex and large defects often require regional or free flaps, particularly when intranasal flaps have been exhausted. Read More

Int J Oral Maxillofac Surg 2018 Jul 24. Epub 2018 Jul 24.

Department of Otolaryngology, Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Institute of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Oral Pathology and Oral Medicine, Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.

The purpose of this study was to compare the histopathological parameters of chronic/suppurative osteomyelitis, medication-related osteonecrosis of the jaw (MRONJ), and osteoradionecrosis (ORN), and to examine the hypothesis that distinct histological features can be related to a specific disease, allowing for diagnosis based on microscopic evaluation alone. One hundred and ten samples were reviewed by two examiners in a blinded fashion, and a semi-quantitative histomorphometric analysis was performed. The parameters evaluated included the presence or absence of necrotic bone, inflammation, reactive bone formation, bacteria, and osteoclasts. Read More

Auris Nasus Larynx 2018 Jul 23. Epub 2018 Jul 23.

Otorhinolaryngology Department, University Malaya Medical Centre, 46200 Kuala Lumpur, Malaysia.

Nasopharyngeal carcinoma is a neoplasm commonly found in population of South East Asia. The mainstay of treatment is high dose irradiation. Complications from radiotherapy are not uncommon especially to those nearby structures such as vertebrae and spinal cord. Read More

Plast Reconstr Surg 2018 Oct;142(4):1025-1034

Houston, Texas From the Division of Plastic Surgery, Baylor College of Medicine; and the Department of Plastic Surgery, The University of Texas M. D. Anderson Cancer Center.

Background: Many surgeons are hesitant to use interposition vein grafting in head and neck microvascular free flap surgery because of concerns for elevated risk of flap loss.

Methods: The authors conducted a review of patients who underwent head and neck free flap reconstruction between 2005 and 2015. The effect of vein grafts on flap compromise and flap loss was analyzed using univariate and multivariate models. Read More

J Craniomaxillofac Surg 2018 Sep 30;46(9):1631-1636. Epub 2018 Jun 30.

Department of Oral and Maxillofacial Surgery, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. Electronic address:

Diffuse sclerosing osteomyelitis (DSO) of the mandible is a poorly understood chronic disease. It is assumed to be a form of chronic osteomyelitis. Other forms of chronic osteomyelitis are chronic suppurative osteomyelitis (CSO) and osteoradionecrosis (ORN). Read More

J Neurol Surg B Skull Base 2018 Aug 27;79(4):349-352. Epub 2017 Nov 27.

Department of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

 To describe the first experience with a free vastus lateralis muscle-only flap to be used to cover and protect the exposed skull base and carotid artery from radiotherapy-induced skull base osteoradionecrosis (ORN).  Retrospective review of a case series.  Tertiary academic medical center. Read More

Ann Plast Surg 2018 Nov;81(5):548-552

From the Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Objective: The purpose of this study was to evaluate the outcomes of reconstructing through-and-through defects of the hemimandible after debridement of advanced mandibular osteoradionecrosis (ORN) with bilobed trapezius myocutaneous flaps and scapula osteomyocutaneous flaps.

Methods: Six patients with grade III mandibular ORN were treated with debridement of lesions. Type IIb soft tissue and type H hemimandible defects after surgery were reconstructed using bilobed trapezius myocutaneous flaps and scapula osteomyocutaneous flaps including the acromion, spine, and part of the medial scapular border based on the transverse cervical vessels. Read More

Int J Radiat Oncol Biol Phys 2018 Nov 28;102(3):552-555. Epub 2018 Jun 28.

Department of Otolaryngology-Head and Neck Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Purpose: Nasopharyngeal carcinoma (NPC) is a type of malignancy with a high prevalence in southern China and Southeast Asia. The primary treatment modality is radiation therapy (RT). Osteoradionecrosis (ORN) of the skull base remains one of the most serious complications after RT, affecting survival time and quality of life. Read More

Radiologe 2018 Aug;58(8):754-761

Radiologische Klinik, Abt. für Radioonkologie u. Strahlentherapie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland.

Background: Peritumoral normal tissue is inevitably also irradiated during radiotherapy, depending on the location and size of the target volume as well as the cumulative dose. Depending on the temporal course after irradiation acute, subacute, and chronic alterations are described in co-irradiated normal tissue that can be detected by imaging. Radiation damage can be transient or persistent. Read More

Natl J Maxillofac Surg 2018 Jan-Jun;9(1):78-81

Department of Oral and Maxillofacial Surgery, Ministry of Health, Riyadh 13226, India.

A number of dressings containing silver have been recently introduced into the wound care market as increased resistance to antibiotics has become a problem in treating infected wounds. A 54-year-old male, with adenoid cystic carcinoma treated by segmental resection and reconstruction of mandible using reconstruction plate with concomitant radiotherapy, resulted in a deep extraoral nonhealing necrotic, exuding, malodorous, and painful wound. Erythema, eczema, and trophic changes were surrounding the skin. Read More

J Stomatol Oral Maxillofac Surg 2018 Dec 22;119(6):518-522. Epub 2018 Jun 22.

Department of oral and maxillofacial surgery, institut Roi Albert II, cliniques universitaires Saint-Luc, université catholique de Louvain, avenue Hippocrate 10, 1200 Brussels, Belgium. Electronic address:

Osteoradionecrosis (ORN) is one of the most severe complications after head and neck radiotherapy. Once established, ORN is difficult to manage and is traditionally considered to be irreversible. Since the recent understanding of the pathophysiology of ORN is based on the concept of radiation-induced fibrosis, a new therapeutic medical regimen has been proposed comprising the combination of pentoxifylline, tocopherol and clodronate (PENTOCLO). Read More

Dent Clin North Am 2018 Jul;62(3):435-452

Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, University of California, San Francisco, 707 Parnassus Avenue, San Francisco, CA 94143-0758, USA.

This article describes the current applications of various technologies based on either autofluorescence or near-infrared light illumination, tailored to aid practitioners in detecting and quantitatively monitoring oral diseases such as dental caries and oral cancer at the earliest stage of their formation, or in the conservative surgical excision of necrotic bones in diseases such as chronic osteomyelitis, osteoradionecrosis, and medication-related osteonecrosis of the jaw. The data discussed are primarily based on published scientific studies and reviews from case reports, clinical trials, and in vitro and in vivo studies. References have been traced manually, by MEDLINE, or through manufacturer's websites. Read More

Contemp Clin Dent 2018 Apr-Jun;9(2):242-248

Department of Dental and Oral Surgery, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

Aims And Objectives: Osteoradionecrosis (ORN) of the jaw is a significant yet rare complication of radiotherapy (RT) associated with the management of head-and-neck malignancies. Recent decrease in the incidence of ORN following RT to the head and neck is being mainly attributed to refinement in RT techniques and improvement in our understanding of this morbid disease. The aim of this study is to assess the patients with ORN following head-and-neck RT to determine the various contributing risk factors involved in the development of ORN. Read More

Wounds 2018 May;30(5):131-137

Sanford Research; Department of Surgery, University of South Dakota Sanford School of Medicine, Sioux Falls, SD.

Objective: The purpose of this study is to assess healing outcomes in full-thickness mucosal wounds following the use of a porcine urinary bladder matrix to augment mixed oral cavity repairs.

Materials And Methods: A retrospective chart analysis was conducted over a 58-month timespan. Participants included individuals with osteoradionecrosis. Read More

JAMA Facial Plast Surg 2018 Sep;20(5):401-408

Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota.

Importance: The clinical and financial implications of the timing of dental rehabilitation after a fibula free tissue transfer (FFTT) for osteoradionecrosis (ORN) and osteonecrosis (ON) of the mandible have yet to be established.

Objective: To compare the outcomes of primary implantation vs secondary implantation after FFTT for ORN and ON of the mandible.

Design, Setting, And Participants: A retrospective review was conducted of 23 patients at a single tertiary academic referral center undergoing primary implantation or secondary implantation after FFTT for ORN and ON from January 1, 2006, to November 10, 2015. Read More

Oral Maxillofac Surg 2018 Sep 25;22(3):249-259. Epub 2018 May 25.

Department of Oral and Maxillofacial Surgery, People's Dental Academy, People's University, Karond By-Pass, Bhanpur, Bhopal, 462037, India.

Three-dimensional (3-D) printing is a method of manufacturing in which materials like plastic or metal are deposited onto one another in layers to produce a 3-D object. Because of the complex anatomy of craniomaxillofacial structures, full recovery of craniomaxillofacial tissues from trauma, surgeries, or congenital malformations is extremely challenging. 3-D printing of scaffolds, tissue analogs, and organs has been proposed as an exciting alternative to address some of these key challenges in craniomaxillofacial surgery. Read More

J Appl Oral Sci 2018 21;26:e20170172. Epub 2018 May 21.

Núcleo de Odontologia Hospitalar do Hospital Universitário, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.

Background: Osteoradionecrosis of the jaw (ORNJ) is the most severe and complex sequel of head and neck radiotherapy (RT) because of the bone involved, it may cause pain, paresthesia, foul odor, fistulae with suppuration, need for extra oral communication and pathological fracture. We treated twenty lesions of ORNJ using low-level laser therapy (LLLT) and antimicrobial photodynamic therapy (aPDT). The objective of this study was to stimulate the affected area to homeostasis and to promote the healing of the oral mucosa. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Sep 16;126(3):264-271. Epub 2018 Apr 16.

Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Objective: Pain is one of the most problematic symptoms in patients with osteoradionecrosis of the jaws. This study investigated the associations between pain severity and morphologic alterations of the mandibular canal and inferior alveolar nerve, in respective computerized tomography images and resected specimens of mandibular osteoradionecrosis.

Study Design: We assessed 14 lesions in 13 patients who underwent segmental mandibulectomy for surgical debridement and simultaneous reconstruction with free fibula flap (1 patient exhibited bilateral lesions). Read More

Curr Opin Otolaryngol Head Neck Surg 2018 Aug;26(4):254-259

Ochsner Health System New Orleans, Department of Otolaryngology, New Orleans, LA, USA.

Purpose Of Review: Despite recent advances in radiotherapy, osteoradionecrosis (ORN) remains a common and difficult complication of radiation therapy in head and neck cancer patients. Available treatment options are complementary to its complex pathophysiology and the currently available theories of ORN development. The efficacy of hyperbaric oxygen therapy has recently been questioned, and therapies targeting the fibroatrophic process have become a focus of ORN treatment. Read More

Clin Oral Investig 2018 May 3. Epub 2018 May 3.

School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 11031, Taiwan.

Objectives: Determine the association between sialadenitis and osteonecrosis of the jaw (ONJ) in head and neck cancer (HNC) patients with varying severity of sialadenitis, treatment modalities, and cancer locations.

Materials And Methods: A total of 40,168 HNC patients, including 1907 ONJ subjects and 7559 matched comparisons, were enrolled from a Longitudinal Health Insurance Database for Catastrophic Illness Patients of Taiwan between 2000 and 2006. The association with sialadenitis and ONJ was estimated by logic regression and presented as the odds ratio (OR) and 95% confidence intervals (CIs). Read More

Braz Oral Res 2018 3;32:e23. Epub 2018 May 3.

Department of Oral Surgery, Universidade do Sagrado Coração, Bauru, SP, Brazil.

It is largely known that some oral diseases can be diagnosed based upon their clinical manifestation combined with the patient's medical history and generally not depending on examination. This is the case of some bone diseases such as osteoradionecrosis of the jaw (ORNJ), osteomyelitis of the jaw (OMJ), and medication-related osteonecrosis of the jaw (MRONJ). The present study aimed to analyze the histopathological features of these specific bone diseases in order to evaluate similarities and differences. Read More

Oral Oncol 2018 May 16;80:16-22. Epub 2018 Mar 16.

Department of Radiation and Cellular Oncology, University of Chicago, 5758 S. Maryland Avenue, M/C 9006, Chicago, IL 60637, USA. Electronic address:

Objectives: Definitive chemoradiation (CRT) for oral cavity squamous cell carcinoma (OC-SCC) is often criticized for poor efficacy or toxicity. We describe a favorable 20-year experience of primary CRT for locally-advanced OC-SCC.

Materials And Methods: Patients with locally-advanced, stage III/IV OC-SCC receiving primary concomitant CRT on protocols from 1994 to 2014 were analyzed. Read More

J Stomatol Oral Maxillofac Surg 2018 Nov 20;119(5):389-394. Epub 2018 Apr 20.

Unit of Oral and Maxillofacial Surgery, "Magna Græcia" University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy. Electronic address:

Introduction: Numb chin syndrome (NCS) or mental neuropathy (MN) is a disorder characterized by sensory neuropathy on the distribution of the inferior alveolar nerve or mental nerve. The most frequent causes are of odontogenic origin (infections, wrong therapies). Other etiologies are related to primary tumor, metastasis, osteoradionecrosis and medication-related osteonecrosis of the jaw (MRONJ). Read More

J Am Dent Assoc 2018 Jun 11;149(6):432-441. Epub 2018 Apr 11.

Background: Conventional 3-dimensional conformal radiation therapy (3DCRT) for head and neck cancer (HNC) can cause hyposalivation, leading to caries and tooth extraction-related osteoradionecrosis. Intensity-modulated radiation therapy (IMRT) delivers more focused radiation than does 3DCRT. To reduce hyposalivation, the Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) guidelines limit salivary gland radiation dose. Read More