83,024 results match your criteria Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA[Journal]


Treating osteoporosis: a near miss in an unusual case of FGF-23 mediated bone loss.

BMJ Case Rep 2019 Mar 16;12(3). Epub 2019 Mar 16.

Christian Medical College, Vellore, Tamil Nadu, India.

Oncogenic osteomalacia is a potentially curable condition caused by phosphaturic mesenchymal tumours. We present the case of 54-year-old woman who presented with bony pains and muscle weakness, and was erroneously treated with bisphosphonates elsewhere on the basis of Dual Energy X-ray Absorptiometry (bone density) scan that showed 'severe osteoporosis'. Further evaluation revealed the presence of hypophosphatemia, with a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid avid lesion involving left mandible on PET scan. Read More

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http://dx.doi.org/10.1136/bcr-2018-228375DOI Listing

Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases.

Biochem Pharmacol 2019 Mar 13. Epub 2019 Mar 13.

IRMB (Institut of Regenerative Medicine and Biotherapies), Inserm U1183, Univ Montpellier, Montpellier, France. Electronic address:

Over the past years, through in vitro studies and unique animal models, biologists and clinicians have demonstrated that cellular senescence is at the root of numerous age-related chronic diseases including osteoarthritis and osteoporosis. This non-proliferative cellular syndrome can modify other surrounding tissue-resident cells through the establishment of a deleterious catabolic and inflammatory microenvironment. Targeting these deleterious cells through local or systemic seno-therapeutic agent delivery in pre-clinical models improves dramatically clinical signs and extends health span. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.03.017DOI Listing

Functional characterization of the C7ORF76 genomic region, a prominent GWAS signal for osteoporosis in 7q21.3.

Bone 2019 Mar 13. Epub 2019 Mar 13.

Department of Genetics, Microbiology and Statistics, Facultat de Biologia, Universitat de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, IBUB, IRSJD, Barcelona, Catalonia, Spain. Electronic address:

Genome-wide association studies (GWAS) have repeatedly identified genetic variants associated with bone mineral density (BMD) and osteoporotic fracture in non-coding regions of C7ORF76, a poorly studied gene of unknown function. The aim of the present study was to elucidate the causality and molecular mechanisms underlying the association. We re-sequenced the genomic region in two extreme BMD groups from the BARCOS cohort of postmenopausal women to search for functionally relevant variants. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.014DOI Listing

The 2018 Guidelines for the diagnosis and treatment of osteoporosis in Greece.

Arch Osteoporos 2019 Mar 15;14(1):39. Epub 2019 Mar 15.

Hellenic Society for the Study of Bone Metabolism, Athens, Greece.

We report the updated guidelines for the management of osteoporosis in Greece, which include guidance on fracture risk assessment, diagnosis-pharmacological treatment-follow-up of osteoporosis based on updated information, and national evidence from Greek clinical practice and the healthcare setting.

Purpose: The purpose of this report was to update the Guidelines for the Management of Osteoporosis in Greece that was published in 2011.

Methods: In line with the GRADE system, the working group initially defined the main clinical questions that should be addressed when dealing with the diagnosis and management of osteoporosis in clinical practice in Greece. Read More

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http://dx.doi.org/10.1007/s11657-019-0584-3DOI Listing

Risk of institutionalization following fragility fractures in older people.

Osteoporos Int 2019 Mar 15. Epub 2019 Mar 15.

Department of Clinical Gerontology, Robert Bosch Krankenhaus Stuttgart, Auerbachstraße 110, 70376, Stuttgart, Germany.

Previously independent living older people suffering fractures of the hip have a high risk of new admission to a nursing home during the subsequent months. This study shows that older people admitted to hospital for fractures of the pelvis and spine have a similar risk of admission to a nursing home.

Introduction: Fall-related fractures are a serious threat to the health and well-being of older persons. Read More

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http://dx.doi.org/10.1007/s00198-019-04922-xDOI Listing

Performance of predictive tools to identify individuals at risk of non-traumatic fracture: a systematic review, meta-analysis, and meta-regression.

Osteoporos Int 2019 Mar 14. Epub 2019 Mar 14.

Bureau d'information et d'études en santé des populations, Institut National de Santé Publique du Québec, 945, Avenue Wolfe, Québec, G1V 5B3, Canada.

There is no consensus on which tool is the most accurate to assess fracture risk. The results of this systematic review suggest that QFracture, Fracture Risk Assessment Tool (FRAX) with BMD, and Garvan with BMD are the tools with the best discriminative ability. More studies assessing the comparative performance of current tools are needed. Read More

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http://link.springer.com/10.1007/s00198-019-04919-6
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http://dx.doi.org/10.1007/s00198-019-04919-6DOI Listing
March 2019
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Evaluation of the implementation of guidelines on the treatment of osteoporosis in patients with rheumatoid arthritis.

J Rheumatol 2019 Mar 15. Epub 2019 Mar 15.

From Clermont-Ferrand University Hospital, Rheumatology Department, 58 Rue Montalembert, Clermont-Ferrand, FR 63003; University Hospital Clermont-Ferrand, Biostatistics Unit (DRCI); Sorbonne Université, GRC-UPMC 08, Paris France; Pitié Salpêtrière hospital, APHP, Rheumatology department, Paris, France; Rheumatology Department, Cochin Hospital, AP-HP, Paris Descartes University, Paris, France; Clinical Epidemiology and Biostatistics, INSERM (U1153), PRES Sorbonne Paris-Cité, Paris, France. Address correspondence to Sandrine Malochet-Guinamand, Clermont-Ferrand University Hospital, Rheumatology Department, 58 Rue Montalembert, Clermont-Ferrand, FR 63003 Email:

Objective: To assess whether the 2003 and 2014 French guidelines on the prevention and treatment of glucocorticoid-induced osteoporosis (GIOP) and the 2012 updated of French guidelines for the treatment of postmenopausal osteoporosis (PMOP) were applied in patients with rheumatoid arthritis (RA).

Methods: We conducted a cross-sectionnal study of 776 RA patients (19 centers). We collected the data required for the application of the various recommendations (age, gender, prednisone intake, low energy fracture, history in the immediate family of hip fractures, and bone densitometry), anti-osteoporotic drugs and the various factors that may be associated with the application of the recommendations. Read More

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http://dx.doi.org/10.3899/jrheum.180889DOI Listing

Methoxsalen and Bergapten Prevent Diabetes-Induced Osteoporosis by the Suppression of Osteoclastogenic Gene Expression in Mice.

Int J Mol Sci 2019 Mar 14;20(6). Epub 2019 Mar 14.

Department of Food and Nutrition, Sunchon National University, Suncheon 57922, Korea.

This study evaluated whether bergapten and methoxsalen could prevent diabetes-induced osteoporosis and its underlying mechanism. For 10 weeks, bergapten or methoxsalen (0.02%, /) was applied to diabetic mice that were provided with a high-fat diet and streptozotocin. Read More

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http://dx.doi.org/10.3390/ijms20061298DOI Listing

How do glucocorticoids used in rheumatic disease affect body weight? A narrative review of the evidence.

Arthritis Care Res (Hoboken) 2019 Mar 15. Epub 2019 Mar 15.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, School of Biological Sciences, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

Glucocorticoids (GCs) are widely used to effectively treat inflammatory disease, however GCs have a number of recognised side effects. It has been shown that patients and clinicians view these side effects differently, with clinicians most concerned with serious side effects such as osteoporosis and diabetes. Consequently these side effects are well researched with clinical guidelines and recommendations. Read More

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http://dx.doi.org/10.1002/acr.23879DOI Listing

Fall Ascertainment and Development of a Risk Prediction Model Using Electronic Medical Records.

J Am Geriatr Soc 2019 Mar 15. Epub 2019 Mar 15.

Center for Health Research, Kaiser Permanente Hawaii, Honolulu, Hawaii.

Objectives: To examine the use of electronic medical record (EMR) data to ascertain falls and develop a fall risk prediction model in an older population.

Design: Retrospective longitudinal study using 10 years of EMR data (2004-2014). A series of 3-year cohorts included members continuously enrolled for a minimum of 3 years, requiring 2 years pre-fall (no previous record of a fall) and a 1-year fall risk period. Read More

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http://dx.doi.org/10.1111/jgs.15872DOI Listing

ERAMRS: a new MR scoring system for early rheumatoid arthritis of the wrist.

Eur Radiol 2019 Mar 14. Epub 2019 Mar 14.

Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, N.T., Hong Kong.

Purpose: To (i) devise a new semi-quantitative scoring system known as Early Rheumatoid Arthritis Magnetic Resonance Score (ERAMRS) to assess inflammation of the wrist on magnetic resonance imaging in early rheumatoid arthritis and to (ii) test ERAMRS and other MR scoring systems against everyday used clinical scorings.

Materials And Methods: One hundred six treatment-naïve patients (81 females, 25 males, mean age 53 ± 12 years) with early rheumatoid arthritis (ERA) underwent clinical/serological testing as well as 3-T MRI examination of the most symptomatic wrist. Clinical assessment included Disease Activity Score-28 and Health Assessment Questionnaire; erythrocyte sedimentation rate and C-reactive protein were measured. Read More

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http://dx.doi.org/10.1007/s00330-019-06060-8DOI Listing

Estrogen deficiency impairs integrin αβ-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling.

Sci Rep 2019 Mar 15;9(1):4654. Epub 2019 Mar 15.

Mechanobiology and Medical Device Research Group (MMDRG), Biomedical Engineering, National University of, Ireland, Galway, Ireland.

The integrin αβ has been shown to play an important role in osteocyte mechanotransduction. It has been reported that there are fewer β integrin-containing cells in osteoporotic bone cells. Osteocytes cultured in vitro under estrogen deficient conditions demonstrate altered mechanotransduction. Read More

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http://dx.doi.org/10.1038/s41598-019-41095-3DOI Listing

Osteoporosis, Childhood Bullying, Rheumatoid Arthritis, Diabetes Counseling, Inhaled Steroids.

Authors:

Am Fam Physician 2019 Mar;99(6):356

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[SRS-Schwab grade osteotomy combined with satellite rod for thoracolumbar old osteoporotic fracture with severe kyphosis].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Mar;33(3):259-264

Department of Spinal Surgery, Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing Jiangsu, 210008,

Objective: To evaluate the effectiveness of SRS-Schwab grade Ⅳ osteotomy combined with satellite rod for thoracolumbar old osteoporotic fracture with severe kyphosis.

Methods: Between April 2013 and August 2016, 20 cases of thoracolumbar old osteoporotic fracture with severe kyphosis were treated with SRS-Schwab grade Ⅳ osteotomy combined with satellite rod. All the patients were females, aged 49-71 years (mean, 54. Read More

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http://dx.doi.org/10.7507/1002-1892.201808022DOI Listing

Soy Isoflavone Extract Does Not Increase the Intoxicating Effects of Acute Alcohol Ingestion in Human Volunteers.

Front Pharmacol 2019 27;10:131. Epub 2019 Feb 27.

Department of Psychiatry and Legal Medicine and Department of Pharmacology, Therapeutics and Toxicoloy, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, Spain.

Soy beans contain isoflavones, including daidzein and genistein, with biological activities related to therapeutic effects in reducing osteoporosis, decreasing adverse menopausal manifestations, providing protection from cardiovascular diseases, and reducing hormone-dependent cancers and age-related cognitive-decline. Daidzein has been described as inhibiting the aldehyde-dehydrogenase-2 enzyme (ALDH2), and reducing alcohol use in clinical pilot studies. Our aim was to evaluate the possible interactions between a soy extract product and alcohol in a crossover, single blind, randomized study. Read More

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http://dx.doi.org/10.3389/fphar.2019.00131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400998PMC
February 2019

Hypermineralization in the femoral neck of the elderly.

Acta Biomater 2019 Mar 11. Epub 2019 Mar 11.

Department of Materials Engineering, University of British Columbia, Vancouver, BC, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada; Centre for Hip Health and Mobility, Vancouver, BC, Canada. Electronic address:

Hip fragility depends on the decline in bone mass as well as changes in bone microstructure and the properties of bone mineral and organic matrix. Although it is well-established that low bone mass or osteoporosis is a key factor in hip fracture risk, it is striking to observe that 92% of 24 patients who have sustained an intracapsular hip fracture showed hypermineralization at the superior-anterior quadrant, a critical region associated with increased hip fracture risk. In-depth material studies on a total of 12 human cadaver femurs revealed increased degree of mineralization in the hypermineralized tissue: calcium weight percentage as measured by quantitative backscattered electron imaging increased by approximately 15% compared with lamellar bone; mineral-to-matrix ratio obtained by Raman microspectroscopy imaging also increased. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.020DOI Listing

The fate of thoracolumbar surgeries in patients with Parkinson's disease, and analysis of risk factors for revision surgeries.

BMC Musculoskelet Disord 2019 Mar 14;20(1):106. Epub 2019 Mar 14.

Department of Orthopedics Surgery, Bone and Joint Research Center, Chang Gung Memorial Hospital, Chang Gung University, No._5, Fu-Shin Street, Kweishian, Taoyuan, 333, Taiwan.

Background: Compared to patients without Parkinson's disease (PD), patients with PD who underwent spinal surgeries were reported to have a relatively high complication rate. However, studies that analyze surgical risk factors for these patients are limited.

Methods: From October 2004 to April 2015, patients with PD who underwent spinal surgeries at our department were reviewed. Read More

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http://dx.doi.org/10.1186/s12891-019-2481-8DOI Listing

Effects of intravenous zoledronate on bone turnover and bone density persist for at least 11 years in HIV-infected men.

J Bone Miner Res 2019 Mar 14. Epub 2019 Mar 14.

Department of Medicine, University of Auckland, Auckland, New Zealand.

Previously we reported the results of a four-year extension of a two-year randomised placebo-controlled trial showing that the anti-resorptive effects of two annual 4mg doses of zoledronate in HIV-infected men persisted for at least five years after the second dose. We set out to determine whether the effects on bone mineral density (BMD) and bone turnover persist beyond ten years. We invited all participants in the original trial known to be alive and living in New Zealand to attend a further visit approximately 12 years after trial entry and 11 years after their second dose of study medication. Read More

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http://dx.doi.org/10.1002/jbmr.3712DOI Listing

Clinical Update on Osteoporosis.

J Midwifery Womens Health 2019 Mar 14. Epub 2019 Mar 14.

Vanderbilt University School of Nursing, Nashville, TN.

Osteoporosis is described as a silent disease prior to fracture, and the sequelae of an osteoporotic fracture can be devastating. Primary care providers should routinely assess and remediate bone health during wellness visits for women aged at least 50 years. Assessment includes review of a variety of risk factors, bone density testing, and an online fracture risk assessment tool calculation. Read More

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http://dx.doi.org/10.1111/jmwh.12954DOI Listing

Bone Metabolism Markers in Thalassemia Major-Induced Osteoporosis: Results from a Cross-Sectional Observational Study.

Curr Mol Med 2019 Mar 13. Epub 2019 Mar 13.

Hematology/Oncology Unit, First Department of Pediatrics, National and Kapodistrian University of Athens, Thivon & Levadeias, 11527, Goudi, Athens. Greece.

Background: Thalassemia major (TM) patients eventually face many new health conditions, including endocrinopathies and low bone mineral density, usually observed in the aging general population.

Objective: The aim of the current study was to evaluate biomarkers of bone remodeling in TM patients and to compare them with both osteoporotic and healthy population, in order to investigate new therapeutic paths.

Method: Sixty-four patients with TM (32 men and 32 women) participated in the study. Read More

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http://dx.doi.org/10.2174/1566524019666190314114447DOI Listing

[Systemic review of Jintiange Capsules in treatment of postmenopausal osteoporosis].

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(1):186-192

Institute of Basic Research in Clinic Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.

To systemically evaluate the efficacy and safety of Jintiange Capsules in the treatment of postmenopausal osteoporosis(PMOP).Seven literature databases were retrieved systematically,and two reviewers independently searched and screened studies,extracted data,and included all the randomized controlled trials on Jintiange Capsules in the treatment of PMOP.Interventions included comparison of Jintiange Capsules with placebo and routine treatment,and the studies on Jintiange Capsules combined with routine treatment versus conventional treatment were also included. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20180709.007DOI Listing
January 2019
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Decrease of GSK3β Ser-9 Phosphorylation Induced Osteoblast Apoptosis in Rat Osteoarthritis Model.

Curr Med Sci 2019 Feb 13;39(1):75-80. Epub 2019 Mar 13.

Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

Nowadays, the cumulative intake of glucocorticoids has become the most common pathogenic factor for non-traumatic osteonecrosis of the femoral head (ONFH). Apoptosis of osteoblasts is considered as the main reason of ONFH at the molecular level. Glycogen synthase kinase 3β (GSK3β) is an important regulator of cellular differentiation and apoptosis pathway, which can modulate the balance between osteoblasts and osteoclasts. Read More

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http://dx.doi.org/10.1007/s11596-019-2002-xDOI Listing
February 2019

Epidemiological and clinical study of hip fracture in hospitalized elderly patients in Shanghai, China.

Arch Osteoporos 2019 Mar 12;14(1):37. Epub 2019 Mar 12.

Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, Shanghai, 200040, China.

In this study, we attempted to determine the epidemiology and clinical characteristics of hip fracture in the elderly. We find that elderly people with hip fracture have multiple comorbidities and suffer numerous complications.

Introduction: We attempted to explore the epidemiology and clinical characteristics of hip fracture in the elderly. Read More

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http://dx.doi.org/10.1007/s11657-019-0580-7DOI Listing
March 2019
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Stages of sarcopenia, bone mineral density, and the prevalence of osteoporosis in older women.

Arch Osteoporos 2019 Mar 13;14(1):38. Epub 2019 Mar 13.

Faculty of Physical Education, University of Brasília, Asa Norte, Brasilia, Distrito Federal, 70910-900, Brazil.

A better understanding of the relationship between osteoporosis and sarcopenia may help to develop effective preventive and therapeutic strategies. In the present study, the association between different stages of sarcopenia, BMD, and osteoporosis was examined. The salient findings indicate that a dose-response relationship exists between sarcopenia stages and bone-related phenotypes. Read More

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http://link.springer.com/10.1007/s11657-019-0591-4
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http://dx.doi.org/10.1007/s11657-019-0591-4DOI Listing
March 2019
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The Effect of TNF Inhibition on Bone Density and Fracture Risk and of IL17 Inhibition on Radiographic Progression and Bone Density in Patients with Axial Spondyloarthritis: a Systematic Literature Review.

Curr Rheumatol Rep 2019 Mar 12;21(5):20. Epub 2019 Mar 12.

Department of Rheumatology, Hospital for Special Surgery Hospital for Special Surgery, Weill- Cornell Medical School, 535 East 70th Street, New York, NY, 10021, USA.

Purpose Of Review: Osteoporosis in axial spondyloarthritis may be modified by therapy. The purpose of this systematic review is to describe (i) the effect of TNFi on BMD, (ii) the effect of secukinumab on BMD, and (iii) the effect of secukinumab on radiographic disease progression in axSpA.

Recent Findings: We searched PubMed, Embase, and Cochrane using the following retrieval languages: spondyloarthritis, ankylosing spondylitis, TNF, IL-17, x-rays, and osteoporosis. Read More

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http://dx.doi.org/10.1007/s11926-019-0818-9DOI Listing

Predictive factors for the efficacy of denosumab in postmenopausal Japanese women with non-metastatic breast cancer receiving adjuvant aromatase inhibitors: a combined analysis of two prospective clinical trials.

J Bone Miner Metab 2019 Mar 13. Epub 2019 Mar 13.

Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Aromatase inhibitors (AIs) are the gold standard therapy for breast cancer in postmenopausal women. AI suppresses the conversion of androgens to estrogens; however, this results in osteopenia, osteoporosis, and bone fracture, thus reducing the patient's quality of life. The use of adjuvant denosumab reduces the risk of clinical fractures in postmenopausal patients with breast cancer receiving AI. Read More

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http://dx.doi.org/10.1007/s00774-018-00985-8DOI Listing

Opportunistic screening for osteoporosis using thoraco-abdomino-pelvic CT-scan assessing the vertebral density in rheumatoid arthritis patients.

Osteoporos Int 2019 Mar 13. Epub 2019 Mar 13.

Rheumatology department, University Hospital of Nancy, 5 rue du Morvan, 54500, Vandœuvre-Lès-Nancy, France.

Introduction: Screening for osteoporosis is crucial in rheumatoid arthritis (RA) patients. The aim of this study was to assess the value of thoraco-abdomino-pelvic CT-derived bone mineral density (BMD) results in L1, compared to dual energy X-ray absorptiometry (DXA) results for osteoporosis screening in rheumatoid arthritis patients.

Methods: Consecutive RA patients who underwent a CT-scan and DXA within a 2-year period were retrospectively included. Read More

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http://dx.doi.org/10.1007/s00198-019-04931-wDOI Listing

Microporous polysaccharide multilayer coated BCP composite scaffolds with immobilised calcitriol promote osteoporotic bone regeneration both in vitro and in vivo.

Theranostics 2019 30;9(4):1125-1143. Epub 2019 Jan 30.

Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109, Xueyuanxi road, 325027 Wenzhou, China.

Incorporating a biomimetic coating and integrating osteoinductive biomolecules into basic bone substitutes are two common strategies to improve osteogenic capabilities in bone tissue engineering. Currently, the underlying mechanism of osteoporosis (OP)-related deficiency of osteogenesis remains unclear, and few treatments target at OP-related bone regeneration. Herein, we describe a self-assembling polyelectrolyte multilayered (PEM) film coating with local immobilisation of calcitriol (Cal) in biphasic calcium phosphate (BCP) scaffolds to promote osteoporotic bone regeneration by targeting the calcium sensing receptor (CaSR). Read More

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http://dx.doi.org/10.7150/thno.29566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401415PMC
January 2019

Prediction of pivotal pathways and hub genes associated with osteoporosis by Gibbs sampling.

Authors:
Yiyun Tan Lei Liu

Exp Ther Med 2019 Mar 16;17(3):2107-2112. Epub 2019 Jan 16.

Department of Pain, Qianfo Shan Hospital, Jinan, Shandong 250014, P.R. China.

Osteoporosis (OP) is a common metabolic bone disease with high incidence, and is recognized as a major public health problem worldwide. It is essential to clarify the pathogenesis of the disease for improving the diagnosis, prevention and treatment of OP. The aim of this study was to clarify the pivotal pathways and hub genes in OP using Gibbs sampling. Read More

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http://dx.doi.org/10.3892/etm.2019.7180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395965PMC

The association of reduced bone density with paraspinal muscle atrophy and adipose tissue in geriatric patients: a cross-sectional CT study

Turk J Med Sci 2019 Mar 14;49(2). Epub 2019 Mar 14.

Background/aim: The aim of the study is to examine the relationship among bone density, adipose tissue, and muscle mass with abdominal CT in geriatric patients.

Materials And Methods: The study is a retrospective cohort study of patients 65 years and over who underwent abdominal CT for any reason between October 2017 and July 2018. Third lumbar vertebra density, fatty degeneration of the paraspinal muscle, subcutaneous adipose tissue, and mesenteric adipose tissue ratio were evaluated. Read More

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http://dx.doi.org/10.3906/sag-1809-48DOI Listing

The therapeutic potential of microRNAs as orthobiologics for skeletal fractures.

J Bone Miner Res 2019 Mar 13. Epub 2019 Mar 13.

Department of Orthopaedics, Stony Brook University, Stony Brook, NY.

The repair of a fractured bone is critical to the well-being of humans. Failure of the repair process to proceed normally can lead to complicated fractures, exemplified by either a delay in union or a complete nonunion. Both of these conditions lead to pain, the possibility of additional surgery, and impairment life quality. Read More

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http://doi.wiley.com/10.1002/jbmr.3708
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http://dx.doi.org/10.1002/jbmr.3708DOI Listing
March 2019
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TRANSIENT OSTEOPOROSIS: CLINICAL SPECTRUM IN ADULTS AND ASSOCIATED RISK FACTORS.

Endocr Pract 2019 Mar 13. Epub 2019 Mar 13.

From: Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Medicine; Mayo Clinic, Rochester, Minnesota, USA.

Objective: We aimed to describe the natural history of the rare clinical syndrome of transient osteoporosis (TO) and ascertain potential risk factors.

Design: Retrospective cohort study of adults with TO at Mayo Clinic, Rochester over 15 years.

Methods: Adults with acute onset joint pain worsened by weight bearing and bone marrow edema on MRI were included; exclusion criteria were trauma, tumors, rheumatic diseases, avascular necrosis, infection and hyperesthesia. Read More

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http://dx.doi.org/10.4158/EP-2018-0626DOI Listing
March 2019
2 Reads

ERα and Wnt/β‑catenin signaling pathways are involved in angelicin‑dependent promotion of osteogenesis.

Mol Med Rep 2019 Mar 1. Epub 2019 Mar 1.

Key Laboratory for Rare and Uncommon Diseases of Shandong Province, Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, P.R. China.

Reports of the ameliorative effect of angelicin on sex hormone deficiency‑induced osteoporosis have highlighted this compound as a candidate for the treatment of osteoporosis. However, the molecular mechanisms of action of angelicin on osteoblast differentiation have not been thoroughly researched. The aim of the present study was to evaluate the effect of angelicin on the proliferation, differentiation and mineralization of rat calvarial osteoblasts using a Cell Counting Kit‑8, alkaline phosphatase activity and the expression of osteogenic genes and proteins. Read More

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http://dx.doi.org/10.3892/mmr.2019.9999DOI Listing

Short-term risk factors for a second hip fracture in a UK population.

Eur J Orthop Surg Traumatol 2019 Mar 12. Epub 2019 Mar 12.

Leeds Teaching Hospitals, Great George St, Leeds, LS1 3EX, UK.

Introduction: A hip fracture carries significant morbidity and mortality-a second fracture of the contralateral hip carries even higher complications. Most second hip fractures occur within 48 months of the first. The aim of this study was to comprehensively analyse all identifiable variables that may increase the risk of a contralateral hip fracture within this time period. Read More

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http://link.springer.com/10.1007/s00590-019-02412-8
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http://dx.doi.org/10.1007/s00590-019-02412-8DOI Listing
March 2019
1 Read

Gut Hormones and Their Effect on Bone Metabolism. Potential Drug Therapies in Future Osteoporosis Treatment.

Front Endocrinol (Lausanne) 2019 26;10:75. Epub 2019 Feb 26.

Laboratory of Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Bone homeostasis displays a circadian rhythm with increased resorption during the night time as compared to day time, a difference that seems-at least partly-to be caused by food intake during the day. Thus, ingestion of a meal results in a decrease in bone resorption, but people suffering from short bowel syndrome lack this response. Gut hormones, released in response to a meal, contribute to this link between the gut and bone metabolism. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2019.00075
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http://dx.doi.org/10.3389/fendo.2019.00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399108PMC
February 2019
1 Read

Enhancement of glucose and bone metabolism in ovariectomized rats fed with germinated pigmented rice with giant embryo ( L. cv. Keunnunjami).

Food Nutr Res 2019 6;63. Epub 2019 Mar 6.

Department of Food Science and Nutrition, Brain Korea 21 Plus, Kyungpook National University, Daegu, Korea.

Background: Menopause induces various metabolic disorders due to the rapid decrease of the ovarian hormone estrogen. It is involved in increased risk of obesity, diabetes, dyslipidemia, and osteoporosis. The pigmented giant embryo cultivar is a promising food product for menopause-induced metabolic disorders. Read More

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http://dx.doi.org/10.29219/fnr.v63.1612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405879PMC

Dorsal and ventral thoracic 12 vertebra body height is associated with incident lumbar vertebral fracture in postmenopausal osteoporotic women.

Clin Interv Aging 2019 15;14:375-380. Epub 2019 Feb 15.

Department of Anesthesiology and Pain Medicine, Catholic Kwandong University, College of Medicine, International St. Mary's Hospital, Incheon, Korea,

Purpose: We measured dorsal and ventral thoracic 12 vertebral (T12V) body heights as a way to predict lumbar vertebral fracture (LVF) in postmenopausal women. MRI of dorsal and ventral T12V body heights has not yet been used to investigate their association with LVF. We hypothesized that the dorsal and ventral T12V body height are important morphologic parameters in the prediction of LVF. Read More

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http://dx.doi.org/10.2147/CIA.S199402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388793PMC
February 2019

A join point regression analysis of trends in mortality due to osteoporosis in Spain.

Sci Rep 2019 Mar 12;9(1):4264. Epub 2019 Mar 12.

School of Medicine, University of Cantabria, Santander, Spain.

Osteoporosis is a major health problem in terms of fracture probability and disability. The aim of this ecological study is to identify the temporal trends in osteoporosis mortality in Spain from 1999 to 2015. Data on the Spanish population and number of deaths due to osteoporosis were obtained from the Spanish National Institute for Statistics. Read More

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http://dx.doi.org/10.1038/s41598-019-40806-0DOI Listing

Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders?

Authors:
Kayvan Zainabadi

Pharmacol Res 2019 Mar 9. Epub 2019 Mar 9.

Glenn Center for the Science of Aging, Department of Biology, Koch Institute, MIT, Cambridge, MA 02139, USA. Electronic address:

With an aging population and limited treatment options, osteoporosis currently represents a significant public health challenge. Recent animal studies indicate that longevity-associated SIRT1 may serve as an attractive pharmacological target for the treatment of osteoporosis and other bone related disorders. Pre-clinical studies demonstrate that mice treated with SIRT1 agonists show protection against age-related, post-menopausal, and disuse models of osteoporosis. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.03.007DOI Listing

Urinary phytate concentration and risk of fracture determined by the FRAX index in a group of postmenopausal women

Turk J Med Sci 2019 Mar 13;49(2). Epub 2019 Mar 13.

Background/aim: This study was designed to evaluate the relationship between urinary phytate concentration and risk of fracture at 10 years, determined by using the FRAX model, in women who had undergone menopause within 5 years of the time of enrollment.

Materials And Methods: Of the 212 postmenopausal women evaluated, 69 were excluded because they had urinary phytate concentrations between 0.51 and 0. Read More

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http://dx.doi.org/10.3906/sag-1806-117DOI Listing
March 2019
1 Read

Vitamin C reverses bone loss in an osteopenic rat model of osteoporosis.

Int J Vitam Nutr Res 2019 Mar 12:1-8. Epub 2019 Mar 12.

4 Morgan State University, School of Community Health & Policy, Baltimore, USA.

Fruits and vegetables are rich in vitamin C with antioxidant properties which are known to influence bone quality. This study evaluated whether vitamin C (1000 mg/L) added to drinking water reverses the bone loss in ovariectomized rats. Ninety-day-old female Sprague-Dawley rats were randomly assigned to either sham (n = 14) or ovariecotmized groups (n = 28). Read More

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http://dx.doi.org/10.1024/0300-9831/a000486DOI Listing

Formal and informal health care behaviours of women with chronic illness: A cross-sectional analysis of 1,925 women.

Int J Clin Pract 2019 Mar 12:e13343. Epub 2019 Mar 12.

Faculty of Health, University of Technology Sydney, Broadway, 2007, Australia.

Aim: To describe the health care behaviours of Australian women (45 years and over) diagnosed with a chronic illness.

Methods: This is a cross-sectional sub-study of the 45 and Up Study-the largest study of healthy ageing conducted in the Southern Hemisphere-including 1,932 Australian women (45 years and older) with a self-reported diagnosis of either depression, asthma, diabetes, osteoarthritis, or osteoporosis. Questionnaires were posted to eligible participants between September and December 2016 and included self-reported use of formal and informal health services and health care behaviours, and health practitioner recommendations and monitoring of informal care. Read More

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http://dx.doi.org/10.1111/ijcp.13343DOI Listing
March 2019
2.566 Impact Factor

Evidence of patient beliefs, values, and preferences is not provided in osteoporosis clinical practice guidelines.

Osteoporos Int 2019 Mar 11. Epub 2019 Mar 11.

Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, 3D10, 3280 Hospital Drive NW, Calgary, Alberta, T2N 4Z6, Canada.

We examined how patient beliefs, values, and preferences (BVPs) were included and conceptualized in international osteoporosis guidelines. The majority of guidelines did not mention BVPs. When mentioned, BVPs were conceptualized as preference for one medication over another. Read More

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http://dx.doi.org/10.1007/s00198-019-04913-yDOI Listing

The effects of short-term use of granulocyte colony-stimulating factor on bone metabolism in child cancer patients.

North Clin Istanb 2018 3;5(4):277-281. Epub 2018 Dec 3.

Division of Pediatric Endocrinology, Department of Pediatrics, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.

Objective: The granulocyte colony-stimulating factor (G-CSF) is the most commonly used hematopoietic growth factor recombinant DNA technology. It affects bone metabolism by modulating both osteoclast and osteoblast functions. The aim of the present study was to investigate the effects of short-term use of G-CSF on bone metabolism in children with leukemia and solid tumors. Read More

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http://dx.doi.org/10.14744/nci.2017.59320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371986PMC
December 2018

New Insights Into Monogenic Causes of Osteoporosis.

Front Endocrinol (Lausanne) 2019 25;10:70. Epub 2019 Feb 25.

Folkhälsan Institute of Genetics and University of Helsinki, Helsinki, Finland.

Osteoporosis, characterized by deteriorated bone microarchitecture and low bone mineral density, is a chronic skeletal disease with high worldwide prevalence. Osteoporosis related to aging is the most common form and causes significant morbidity and mortality. Rare, monogenic forms of osteoporosis have their onset usually in childhood or young adulthood and have specific phenotypic features and clinical course depending on the underlying cause. Read More

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http://dx.doi.org/10.3389/fendo.2019.00070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397842PMC
February 2019

Autologous hematopoietic stem cell transplant for progressive diffuse systemic sclerosis: procedural success and clinical outcome in 5-year follow-up.

Reumatologia 2019 28;57(1):50-54. Epub 2019 Feb 28.

Department of Rheumatology and Rehabilitation, Poznań University of Medical Sciences, Poland.

Systemic sclerosis is an autoimmune connective tissue disease affecting both skin and internal organs. Progressive disease with multiple organ involvement is considered to have a poor prognosis. Treatment possibilities are limited, but certain patients may benefit from autologous hematopoietic stem cell transplantation (auto-HSCT). Read More

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http://dx.doi.org/10.5114/reum.2019.83240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409831PMC
February 2019

Oral dosing of pentoxifylline, a pan-phosphodiesterase inhibitor restores bone mass and quality in osteopenic rabbits by an osteogenic mechanism: A comparative study with human parathyroid hormone.

Bone 2019 Mar 8. Epub 2019 Mar 8.

Division of Endocrinology, CSIR-Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow 226031, India. Electronic address:

The non-selective phosphodiesterase inhibitor pentoxifylline (PTX) is used for the treatment of intermittent claudication due to artery occlusion. Previous studies in rodents have reported salutary effects of the intraperitoneal administration of PTX in segmental bone defect and fracture healing, as well as stimulation of bone formation. We determined the effect of orally dosed PTX in skeletally mature ovariectomized (OVX) rabbits with osteopenia. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.010DOI Listing