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Am J Ther 2020 Jun 22. Epub 2020 Jun 22.

Department of Dentistry, Sri Aurobindo Institute of Medical Sciences, Indore, India.

Medication-related osteonecrosis of the jaw (MRONJ) is a painful and intractable disease of the jaw that clinically presents as an area of ulceration with exposed necrotic bone. In severe cases, it can predispose to jaw fracture, skin fistula, or osteolysis extending beyond the region of the alveolar bone. No effective treatment has been established for this condition. Read More

FASEB Bioadv 2020 Jun 10;2(6):365-381. Epub 2020 Jun 10.

Department of Matrix Medicine Faculty of Medicine Oita University Yufu Oita Japan.

Low bone mineral density (BMD)-diagnosed as osteoporosis or osteopenia-has been reported as a new characteristic feature of Fabry disease; however, the mechanism underlying the development of low BMD is unknown. We previously revealed that a mouse model of Fabry disease [] exhibits impaired functioning of medullary thick ascending limb (mTAL), leading to insufficient Ca reabsorption and hypercalciuria. Here, we investigated bone metabolism in mice without marked glomerular or proximal tubular damage. Read More

PLoS Med 2020 Jul 2;17(7):e1003152. Epub 2020 Jul 2.

Centre for Clinical Epidemiology, Department of Medicine, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.

Background: Since screening programs identify only a small proportion of the population as eligible for an intervention, genomic prediction of heritable risk factors could decrease the number needing to be screened by removing individuals at low genetic risk. We therefore tested whether a polygenic risk score for heel quantitative ultrasound speed of sound (SOS)-a heritable risk factor for osteoporotic fracture-can identify low-risk individuals who can safely be excluded from a fracture risk screening program.

Methods And Findings: A polygenic risk score for SOS was trained and selected in 2 separate subsets of UK Biobank (comprising 341,449 and 5,335 individuals). Read More

Patient Prefer Adherence 2020 23;14:1049-1064. Epub 2020 Jun 23.

Eli Lilly Interamerica Inc, Bogotá, Colombia.

Purpose: Teriparatide is used to treat patients with established osteoporosis but is often reserved for patients who have inadequate response to antiresorptive therapy. Biosimilar teriparatide, which is believed to have efficacy and safety similar to the originator product, is now available in Colombia. However, little is known about patients' preferences for originator biologic and biosimilar treatments. Read More

Int J Chron Obstruct Pulmon Dis 2020 15;15:1377-1390. Epub 2020 Jun 15.

NIHR Nottingham BRC Respiratory Theme, School of Medicine, University of Nottingham, City Hospital Campus, Nottingham, UK.

Introduction: Osteoporosis and bone fractures are common in chronic obstructive pulmonary disease (COPD) and contribute significantly to morbidity and mortality. Current national guidance on COPD management recommends addressing bone health in patients, however, does not detail how. This consensus outlines key elements of a structured approach to managing bone health and fracture risk in patients with COPD. Read More

Int J Mol Sci 2020 Jun 28;21(13). Epub 2020 Jun 28.

Department of Head and Skin, Division of Neurology, Ghent University and Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium.

In Duchenne muscular dystrophy (DMD), the activation of proinflammatory and metabolic cellular pathways in skeletal muscle cells is an inherent characteristic. Synthetic glucocorticoid intake counteracts the majority of these mechanisms. However, glucocorticoids induce burdensome secondary effects, including hypertension, arrhythmias, hyperglycemia, osteoporosis, weight gain, growth delay, skin thinning, cushingoid appearance, and tissue-specific glucocorticoid resistance. Read More

Bone Joint J 2020 Jul;102-B(7):881-889

Kantonsspital Baden, Baden, Switzerland.

Aims: Conservative treatment of moderately displaced proximal humeral head fractures yields good clinical results, but secondary fragment displacement may occur. Identification of those fractures at risk of displacement may influence initial decision-making.

Methods: A total of 163 shoulders in 162 patients with conservatively treated isolated proximal humeral fractures were included. Read More

Arch Osteoporos 2020 Jun 25;15(1):97. Epub 2020 Jun 25.

Institute of Clinical Medicine, University of Copenhagen, Blegdansvej 3B, 2200, Copenhagen N, Denmark.

In Denmark, osteoporosis treatment is either handled by general practitioners or at more resource demanding specialist clinics. We evaluated the treatment adherence and persistence in the two settings, which were overall similar. The type of medical support did, however, differ and was provided to two very different patient populations. Read More

J Nutr 2020 Jun 26. Epub 2020 Jun 26.

Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands.

Background: Hong Kong faces several public health problems including malnutrition and osteoporosis. Considering the typical Chinese diet and overall low physical activity levels of Chinese adults, timely interventions to improve nutritional status and bone health are needed.

Objectives: We examined the effects of a nutrition plus exercise intervention on serum vitamin B-12 and 25-hydroxyvitamin D [25(OH)D], bone turnover markers, and parathyroid hormone (PTH) concentrations in apparently healthy Chinese middle-aged and older adults. Read More

Int Q Community Health Educ 2020 Jun 25:272684X20936833. Epub 2020 Jun 25.

Social Determinans of Health Research Center, Tabriz University of Medical Sciences.

Background: Osteoporosis is one of the diseases that can be prevented by correcting health behaviors during adolescence.

Objective: This study was conducted to evaluate the effect of education on preventive behaviors of osteoporosis including physical activity, calcium intake and practice (primary outcomes) and knowledge and attitude related to osteoporosis (secondary outcomes) in adolescents.

Method: A search was done in Cochrane Library, PubMed, Embase, Web of Sciences, Scopus, Google Scholar, SID and Magiran regardless of the time limit. Read More

Expert Rev Endocrinol Metab 2020 Jul 25;15(4):283-298. Epub 2020 Jun 25.

Department of Medicine, Surgery and Neurosciences, University of Siena, Siena , Italy.

Introduction: Endogenous or exogenous (corticosteroid-induced) glucocorticoids (GCs) excess represents, together with diabetes, the most common cause of secondary osteoporosis.

Areas Covered: We present a comprehensive overview about the pathophysiology, clinical management and treatment of GCs induced osteoporosis (GIOP). According to PRISMA guidelines, a literature search identifying articles about bone and GCs was done. Read More

J Bone Metab 2020 May 31;27(2):133-142. Epub 2020 May 31.

Department of Orthopaedic Surgery, Konyang University Hospital, Daejeon, Korea.

Background: American Society for Bone and Mineral Research recommend the use of intramedullary reconstruction of full length-nail for atypical subtrochanteric femoral fracture (ASFF). However, there is no study on the incidence of the ipsilateral femoral fracture after index operation of ASFF, and full-length nail has disadvantage as iatrogenic fracture and leg length discrepancy (LLD). The aim of this study was to investigate the incidence of ipsilateral secondary fracture after using partial-length nail, and to compare the outcomes on surgery of ASFF between partial length-nails and full length-nails. Read More

J Bone Metab 2020 May 31;27(2):79-83. Epub 2020 May 31.

Department of Orthopaedic Surgery, Eulji University Hospital, Daejeon, Korea.

Osteoporosis and osteoporosis related fractures contribute a large part of the medical cost in developed countries. Considering the preventive effect of osteoporotic medications, high rate of mortality and complications, poor quality of life after osteoporosis related fractures, the growing trend of older populations in the future, osteoporosis and osteoporosis related fractures are important targets of preventive treatment and also targets of socioeconomic cost reduction. Treating osteoporosis and preventing osteoporosis related fractures have become an essential element in Korean medical system. Read More

Medicine (Baltimore) 2020 Jun;99(25):e20524

Department of Minimally Invasive Spine Surgery, the Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, No.109, Xueyuan Western Road, Wenzhou City, Zhejiang Province, P.R. China.

Background: It is currently controversial whether unilateral or bilateral balloon kyphoplasty (BKP) is superior in terms of postoperative outcomes in treatment of osteoporotic vertebral compression fracture (OVCF). In this context, the aim of this study was to prospectively evaluate and compare the radiographic and clinical outcomes of BKP using unilateral and bilateral approaches.

Methods: This was a randomized controlled study and was approved by the Severance Institutional Review Board in our hospital. Read More

J Complement Integr Med 2020 Jun 19. Epub 2020 Jun 19.

Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran.

Objectives Phytomedicine is widely suggested for the prevention of chronic disease, but evidence for a favorable effect on bone health is lacking. The present study will investigate the Zingiber officinale (ZO) and Curcuma longa L. (CL) supplementation effects on quality of life, body composition, bone mineral density (BMD) and osteoporosis related biomarkers and micro-RNAs in women with postmenopausal osteoporosis (PMO). Read More

Geriatr Orthop Surg Rehabil 2020 28;11:2151459320929581. Epub 2020 May 28.

Rubin Institute for Advanced Orthopedics, Center for Joint Preservation and Replacement, Sinai Hospital of Baltimore, MD, USA.

Background: Hip fractures are a common condition associated with high morbidity and mortality. In this study, we assess (1) yearly incidences, (2) demographic factors, (3) postoperative outcomes, (4) primary diagnoses, and (5) primary procedures.

Materials And Methods: The National Inpatient Sample was queried for patients admitted with hip fractures from 2009 to 2016 (n = 2 761 850). Read More

Osteoporos Int 2020 Jun 15. Epub 2020 Jun 15.

McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada.

Although high-dose vitamin D supplementation is common, effects on arterial calcification remain unexplored. Tibial artery calcification was identified and quantified over 3 years in participants randomized to 400, 4000, or 10,000 IU vitamin D daily. High-dose vitamin D supplementation did not affect the development or progression of arterial calcification. Read More

Endocrinol Diabetes Metab Case Rep 2020 Jun 4;2020. Epub 2020 Jun 4.

Department of Medicine and Surgery, Endocrine Unit, University of Insubria, Varese, Italy.

Summary: Brown tumors are osteoclastic, benign lesions characterized by fibrotic stroma, intense vascularization and multinucleated giant cells. They are the terminal expression of the bone remodelling process occurring in advanced hyperparathyroidism. Nowadays, due to earlier diagnosis, primary hyperparathyroidism keeps few of the classical manifestations and brown tumors are definitely unexpected. Read More

Br J Gen Pract 2020 Jun;70(suppl 1)

Barking, Havering and Redbridge University Hospitals NHS Trust.

Background: Osteoporosis is a major public health problem with the ageing population in the UK. However, there is no known national algorithm for the management of osteoporosis in primary care. Therefore, a treatment pathway was developed in secondary care for patients in the community. Read More

J Diabetes Metab Disord 2020 Jun 14;19(1):431-435. Epub 2019 Nov 14.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Shariati Hospital, 5th floor, North Kargar Ave. P.C., Tehran, 14114-13137 Iran.

Purpose: Prevalence of osteoporosis reported as high as 50% in thalassemia major patients. We compared bone density (BMD) of our patients with results of bone densitometry of participants of a national study, to find if BMD diagnosis is ethnicity sensitive or not.

Methods: In 177 adult beta thalassemia major patients and 490 normal subjects of 20-39 y/o range, dual-energy X-ray absorptiometry of the spine and femur performed. Read More

Arch Osteoporos 2020 Jun 16;15(1):89. Epub 2020 Jun 16.

Primary Care Centre Versus Arthritis, School of Primary, Community and Social Care, Keele University, Stoke-on-Trent, ST5 5BG, UK.

Four focus groups were conducted with members of the public to identify important areas for future osteoporosis research. Participants identified priorities to increase public awareness of osteoporosis, reduce delays in diagnosis, improve communication between healthcare providers and to improve follow-up and information provision about causes of osteoporosis, medication harms and prognosis.

Purpose: Patients and the public must be involved in setting research agendas to ensure relevant and impactful questions are prioritised. Read More

Front Cell Dev Biol 2020 29;8:399. Epub 2020 May 29.

Institute of Clinical Physiology (IFC-CNR), Research Unit of Reggio Calabria, Reggio Calabria, Italy.

Paget bone disease (PDB) is often asymptomatic and incidentally diagnosed. It is a cause of osteoporosis and bone fragility and exposes patients to a high incidence of bone fractures. In Europe the prevalence varies according to the geographical area of origin, and increases with age. Read More

Cancers (Basel) 2020 Jun 12;12(6). Epub 2020 Jun 12.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Monoclonal Gammopathy of Undetermined Significance (MGUS) is considered to be a benign precursor condition that may progress to a lymphoproliferative disease or multiple myeloma. Most patients do not progress to an overt condition, but nevertheless, MGUS is associated with a shortened life expectancy and, in a minority of cases, a number of co-morbid conditions that include an increased fracture risk, renal impairment, peripheral neuropathy, secondary immunodeficiency, and cardiovascular disease. This review aims to consolidate current evidence for the significance of these co-morbidities before considering how best to approach these symptoms and signs, which are often encountered in primary care or within a number of specialties in secondary care. Read More

Eur J Endocrinol 2020 Jun 1. Epub 2020 Jun 1.

A Ferlin, Department of Clinical and Experimental Sciences, Unit of Endocrinology and Metabolism, University of Brescia, Brescia, Italy.

Male osteoporosis has been neglected for too long time and there is need for a change. This condition is clearly under-estimated, under-diagnosed and under-treated. The diagnosis is often made late in the natural history of the pathology or even after a fracture event. Read More

JAMA 2020 06;323(23):2388-2396

Jaeb Center for Health Research, Tampa, Florida.

Importance: Adolescents and young adults with type 1 diabetes exhibit the worst glycemic control among individuals with type 1 diabetes across the lifespan. Although continuous glucose monitoring (CGM) has been shown to improve glycemic control in adults, its benefit in adolescents and young adults has not been demonstrated.

Objective: To determine the effect of CGM on glycemic control in adolescents and young adults with type 1 diabetes. Read More

Ageing Res Rev 2020 Jun 12;62:101098. Epub 2020 Jun 12.

Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China; Li Ka Shing Health and Science Institute, The Chinese University of Hong Kong, Hong Kong, China; Joint Laboratory of Chinese Academic of Science and Hong Kong for Biomaterials, The Chinese University of Hong Kong, Hong Kong, China; Translational Medicine Research and Development Center, Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, China. Electronic address:

Osteoporosis is a highly prevalent disorder characterized by the loss of bone mass and microarchitecture deterioration of bone tissue, attributed to various factors, including menopause (primary), aging (primary) and adverse effects of relevant medications (secondary). In recent decades, knowledge regarding the etiological mechanisms underpinning osteoporosis emphasizes that bone cellular homeostasis, including the maintenance of cell functions, differentiation, and the response to stress, is tightly regulated by autophagy, which is a cell survival mechanism for eliminating and recycling damaged proteins and organelles. With the important roles in the maintenance of cellular homeostasis and organ function, autophagy has emerged as a potential target for the prevention and treatment of osteoporosis. Read More

Bone 2020 Jun 11;138:115478. Epub 2020 Jun 11.

Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece. Electronic address:

Introduction: In women with postmenopausal osteoporosis denosumab discontinuation is associated with rapid bone loss that could be potentially prevented by a single zoledronate infusion for two years. The longer-term effects, however, of zoledronate treatment are unknown. We aimed to study the effect of a single zoledronate infusion during the third year following denosumab discontinuation, in initially treatment-naive postmenopausal women who became osteopenic after 2. Read More

Turk Neurosurg 2020 May 9. Epub 2020 May 9.

University of Health Sciences, Gaziosmanpasa Training and Research Hospital, Department of Neurosurgery, Istanbul, Turkey.

Aim: Spinal metastases may cause acute vertebral fracture.Compression fractures may develop in the metastatic vertebra corpus after minor trauma.This retrospective clinical study sought to elucidate the characteristics of kyphoplasty in correlation with spinal metastasis. Read More

Bioorg Med Chem Lett 2020 Jul 8;30(14):127250. Epub 2020 May 8.

Division of Crop Foundation, National Institute of Crop Science (NICS), Rural Development Administration (RDA), Wanju 55365, Republic of Korea. Electronic address:

Seedlings of natural crops are valuable sources of pharmacologically active phytochemicals. In this study, we aimed to identify new active secondary metabolites in Avena sativa L. (oat) seedlings. Read More

Endocrine 2020 Jun 10. Epub 2020 Jun 10.

Department of Endocrinology, University Hospital of Brasilia, University of Brasilia, Brasilia, Brazil.

Purpose: Acromegaly is considered an important cause of secondary osteoporosis. However, studies on bone mineral density (BMD) have yielded conflicting results and there are few studies that evaluate an accurate imaging method for early diagnosis of osteoporosis in these patients. The objective of this study was to assess whether entropy and uniformity on computed tomography (CT) scans are useful parameters for optimization of assessment of bone fragility in patients with acromegaly. Read More

JAMA Netw Open 2020 Jun 1;3(6):e207419. Epub 2020 Jun 1.

Department of Surgery, Rush University Medical Center, Chicago, Illinois.

Importance: Given the complex relationship between body mass index, body composition, and bone density and the correlative nature of the studies that have established the prevailing notion that higher body mass indices may be protective against osteopenia and osteoporosis and, therefore, fracture, the absolute risk of fracture in patients with severe obesity who undergo either Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) compared with those who do not undergo bariatric surgery is unknown.

Objective: To assess the rates of fractures associated with obesity and compare rates between those who do not undergo bariatric surgery, those who undergo RYGB, and those who undergo SG.

Design, Setting, And Participants: In this retrospective multicenter cohort study of Medicare Standard Analytic Files derived from Medicare parts A and B records from January 2004 to December 2014, patients classified as eligible for bariatric surgery using the US Centers of Medicare & Medicaid criteria who either did not undergo bariatric surgery or underwent RYGB or SG were exactly matched in a 1:1 fashion based on their age, sex, Elixhauser Comorbidity Index, hypertension, smoking status, nonalcoholic fatty liver disease, hyperlipidemia, type 2 diabetes, osteoporosis, osteoarthritis, and obstructive sleep apnea status. Read More

Front Med 2020 Jun 9. Epub 2020 Jun 9.

Disease & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, 310024, China.

Bone mass is a key determinant of osteoporosis and fragility fractures. Epidemiologic studies have shown that a 10% increase in peak bone mass (PBM) at the population level reduces the risk of fracture later in life by 50%. Low PBM is possibly due to the bone loss caused by various conditions or processes that occur during adolescence and young adulthood. Read More

Pain Physician 2020 Jun;23(3):315-324

University of Colorado, Aurora, Colorado.

Background: Vertebral cement augmentation is a commonly used procedure in patients with vertebral body compression fractures from primary or secondary osteoporosis, metastatic disease, or trauma. Many of these patients present with radiculopathy as a presenting symptom, and can experience symptomatic relief following the procedure.

Objectives: To determine the incidence of preprocedural radiculopathy in patients with vertebral body compression fractures presenting for cement augmentation, and present their postoperative outcomes. Read More

Sports (Basel) 2020 Jun 4;8(6). Epub 2020 Jun 4.

Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Lund University, 20502 Malmö, Sweden.

Physical activity (PA) may improve brain development, cognition, concentration and academic performance. In this prospective controlled intervention study, we increased the level of PA in 338 children aged 6-8 years at study start, from the Swedish standard of 60 min per week to 200 min per week (40 min daily). The intervention continued in all nine compulsory school years until the students graduated between 2007-2012. Read More

BMC Geriatr 2020 Jun 5;20(1):196. Epub 2020 Jun 5.

Epi-Centre for Healthy Ageing, Deakin University, PO Box 281, Geelong, Victoria, 3220, Australia.

Background: Frailty is characterised by age-related declines in physical, psychological and social functioning. Features of frailty overlap with risk factors for fragility fractures. The aim of this study was to investigate the association between the fracture risk assessment tool (FRAX®) and frailty. Read More

Trials 2020 Jun 3;21(1):466. Epub 2020 Jun 3.

Clinical Pharmacology Department, Clinical Trial Unit, La Paz University Hospital - IdiPAZ, Paseo de la Castellana, 261, 28046, Madrid, Spain.

Objectives: Primary objective: to evaluate the efficacy of melatonin as a prophylactic treatment on prevention of symptomatic SARS-CoV-2 infection among healthcare workers at high risk of SARS-CoV-2 exposure. Secondary objectives: To evaluate the efficacy of melatonin as a prophylactic treatment on prevention of asymptomatic SARS-CoV-2 infection.To evaluate the efficacy of melatonin to prevent the development of severe COVID-19 in the participants enrolled in this study who develop SARS-CoV-2 infection along the trial. Read More

Trials 2020 Jun 3;21(1):465. Epub 2020 Jun 3.

The First Affiliated Hospital of Yunnan University of Chinese Medicine, No.120 Guanghua Road, Wuhua District, Kunming, 650032, Yunnan Province, China.

Background: Osteoporosis is becoming more prevalent in aging societies worldwide, and the economic burden attributable to osteoporotic fractures is substantial. The medications presently available to treat osteoporosis have side effects. Acupuncture is widely used for treating osteoporotic postmenopausal women because it is non-invasive and has fewer side effects, but the powerful clinical evidence for its efficacy remains insufficient. Read More

Dtsch Med Wochenschr 2020 Jun 3;145(11):728-732. Epub 2020 Jun 3.

Bereich Endokrinologie/Diabetes/Metabolische Knochenerkrankungen, Medizinische Klinik III & UniversitätsCentrum für Gesundes Altern (UCGA), Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden.

The global prevalence of osteoporotic fractures and the socioeconomic burden is increasing with aging of the population. Frailty, sarcopenia, malnutrition and a propensity to falls are contributing to osteoporotic fractures in old age with an estimated 750 000 fragility fractures per year in Germany. Despite this increasing number of fractures, osteoporosis remains underdiagnosed and undertreated in the geriatric population. Read More

Acta Orthop Belg 2020 Mar;86(1):82-94

Aseptic loosening of total knee arthroplasty (TKA) components is one of the frequent reasons for early revision together with infection and instability. Aseptic loosening is usually preceded by the observation of radiolucent lines (RLL) on radiographs. Radiolucent lines have conventionally been considered a sign of osteolysis due to particles disease of either polyethylene or cement wear. Read More

Eur J Clin Nutr 2020 Jun 1. Epub 2020 Jun 1.

Department of Social Medicine, Preventive Medicine and Nutrition, Medical School, University of Crete, Heraklion, Greece.

Objective: Nutritional disorders cause secondary osteoporosis as well as musculoskeletal metabolism dysfunction. The Christian Orthodox Church's fasting in Mediterranean countries such Greece and Cyprus, or M.C. Read More

Medicine (Baltimore) 2020 May;99(21):e20379

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.

Introduction: Osteoporosis (OP) and related fragility fractures are a significant public health problem which leads to pain, disability, loss function of independence, considerable complications and increased mortality. Exercise training is the only alternative strategy to improve multiple skeletal and fall risk factors simultaneously. Wuqinxi is 1 of the Chinese mind-body exercises using to improve physical and mental health and fight against diseases for thousands of years. Read More

Arch Osteoporos 2020 May 28;15(1):80. Epub 2020 May 28.

Department of Orthopaedic Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA.

In this retrospective study, approximately 77% of patients who attended their osteoporosis clinic follow-up appointments following a fragility fracture were started on medical treatment. Approximately 82% of those patients were adherent with their treatment, and 1% of patients sustained a secondary fragility fracture while on treatment.

Purpose: To assess the effects of implementation of a fracture liaison service at a tertiary care academic medical center on osteoporosis treatment adherence and secondary fracture rates. Read More

Physiother Theory Pract 2020 May 29:1-8. Epub 2020 May 29.

Physical Therapy, Campbell University College of Pharmacy and Health Sciences , Buies Creek, NC, USA.

Introduction: Forward flexed posture is an impairment in body structure commonly seen among older adults and those with pathologies such as ankylosing spondylitis and osteoporosis. Accurate measurement of forward flexed posture is important as it is related to pain, mobility limitations, and falls. Our purpose was to examine the reliability and determinants of forward flexed posture as indicated by tragus-to-wall (TTW) distance. Read More

Eur J Nutr 2020 May 27. Epub 2020 May 27.

Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, L7 8TX, England.

Purpose: To evaluate the association between Baltic Sea diet (BSD) and Mediterranean diet (MED) with frailty.

Methods: This was a secondary analysis on the osteoporosis risk factor and prevention-fracture prevention study on 440 women aged 65-72 years. Frailty was ascertained with the presence of 3-5 and prefrailty 1-2 of the following criteria: weight loss ≥ 5%, low life satisfaction score, walking speed ≤ 0. Read More

Arch Osteoporos 2020 May 26;15(1):79. Epub 2020 May 26.

Division of Geriatrics, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Clinicians and patients want to know if therapy is working early in their course of treatment. We found that early changes in bone turnover markers at 6 months were associated with long-term changes in bone mineral density but not trabecular bone score at 12 and 24 months.

Purpose: We sought to examine the association between shorter-term changes in markers of bone turnover and longer-term changes in bone mineral density (BMD) and microstructure in a cohort of frail elderly women with multiple comorbid conditions including osteoporosis. Read More

Clin Investig Arterioscler 2020 May 23. Epub 2020 May 23.

Laboratorio de Farmacología Experimental Básica y Traslacional, Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Centro Universitario, Mendoza, Argentina; Instituto de Medicina y Biología Experimental de Cuyo, Consejo Nacional de Investigación Científica y Tecnológica (IMBECU-CONICET), Mendoza, Argentina. Electronic address:

Vitamin D deficiency is a worldwide pandemic and results in osteoporosis, hypertension, and other cardiovascular diseases. At the cellular level, it produces significant oxidative stress, inflammatory markers, and mitochondrial damage. There is increasing evidence about the role of vitamin D in the regulation of the renin-angiotensin-aldosterone system (RAAS). Read More

J Clin Endocrinol Metab 2020 May 26. Epub 2020 May 26.

SF: Service of Bone Diseases, Geneva University Hospital and Faculty of Medicine, 1211, Geneva 14, Switzerland.

Context: Consensus regarding diagnosis and management of osteoporosis in premenopausal women (PW) is still lacking, due to few studies carried out in this population.

Design: ECTS and IOF convened a working group to produce an updated review of literature published after 2017 on this topic.

Results: Fragility fractures in PW are rare and mostly due to secondary osteoporosis, i. Read More

Bone 2020 May 22;137:115451. Epub 2020 May 22.

Department of Diabetes, Endocrinology & Metabolism, University of Nebraska Medical Center, United States of America. Electronic address:

Patients with type 1 Diabetes Mellitus (T1DM) have an increased risk of fracture. Little is known about the microarchitecture of trabecular bone in T1DM, which may account for some of the increased risk. We report here a secondary analysis comparing Trabecular Bone Score (TBS) derived from DXA to 2-D histomorphometric and 3-D micro-computerized tomography (CT) variables obtained from iliac biopsies in 83 subjects (29 T1DM and 54 controls). Read More