Search Our Scientific Publications & Authors

Eur J Nutr 2019 Apr 16. Epub 2019 Apr 16.

Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia.

Purpose: Osteoporosis is associated with both lower health-related quality of life and depression in older people. We examined the independent and combined effects of a multi-component exercise program and calcium-vitamin D fortified milk on health-related quality of life (HR-QoL) and depression in older men.

Methods: In this 12-month, factorial design randomized controlled trial, 180 healthy community-dwelling men aged 50-79 years with normal to below average bone mineral density were allocated into one of four groups: exercise + fortified milk; exercise; fortified milk; or controls. Read More

Acta Ortop Bras 2019 Mar-Apr;27(2):95-99

Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Department of Orthopedics and Traumatology, São Paulo, SP, Brazil.

Objective: To evaluate the epidemiological profile of patients with osteoporotic fractures compared to patients with osteoarthritis (OA) and identify factors that diminish adherence to secondary prevention.

Methods: A total of 108 patients with osteoporotic fractures (OF) were compared to 86 patients with OA.

Results: Patients in the OF group were older (p < 0. Read More

Biochim Biophys Acta Gen Subj 2019 Apr 10. Epub 2019 Apr 10.

Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada. Electronic address:

Background: Osteoblasts maintain the structural integrity of bone via differentiation and mineralization; therefore, their malfunction or reduced activity can cause serious bone disorders. Although studies have demonstrated the association between nutrients and bone, research on food-derived bioactive peptides and bone health are scanty.

Methods: Osteoblasts MC3T3-E1 were treated with IRW (50 and 25 μM). Read More

J Endocrinol Invest 2019 Apr 12. Epub 2019 Apr 12.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.

Background: Osteoporosis constitutes a major public health problem, through its association with age-related fractures, particularly of the hip, vertebrae, distal forearm, and humerus. Over recent decades, it has evolved from being viewed as an inevitable consequence of ageing, to being recognised as a serious and eminently treatable disease.

Materials And Methods: In this article, we review the literature pertaining to the epidemiology of osteoporosis, associated health burden, approaches to risk assessment and treatment. Read More

Joint Bone Spine 2019 Apr 9. Epub 2019 Apr 9.

Rheumatology Department, Cochin Hospital, 75014 Paris, France; INSERM U1153, 75014 Paris France. Electronic address:

Objective: To evaluate the prevalence of biological abnormalities leading to secondary osteoporosis in recently fractured patients.

Methods: Adults older than 50, hospitalized for a nonvertebral fracture from July 2015 to October 2016, were assessed for bone fragility contributors in the Orthopedics Department. Bone mineral density (BMD) measurements and Vertebral Fracture assessment (VFA) were performed within 3 months. Read More

Int J Orthop Trauma Nurs 2018 Dec 3. Epub 2018 Dec 3.

GF Strong Rehabilitation Research Program, The University of British Columbia, Vancouver, BC, Canada; Centre for Hip Health and Mobility, Vancouver, BC, Canada; The University of Adelaide, Australia. Electronic address:

Background: One in five men will experience an osteoporosis-related fracture in their lifetime. However, osteoporosis is widely perceived as a women's disease and few studies focus specifically on men. Our objective was to identify qualitative evidence to understand men's perceptions of osteoporosis and fracture. Read More

Curr Opin Endocrinol Diabetes Obes 2019 Apr 9. Epub 2019 Apr 9.

Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.

Purpose Of Review: Adrenal tumors occur in 5% of population with higher prevalence in elderly. Patients with adrenal tumors present with overt hormonal excess in up to 15% of cases, and mild autonomous cortisol secretion in 30-40% of cases. Overt Cushing syndrome, mild autonomous cortisol secretion, pheochromocytoma, and primary aldosteronism have been associated with higher cardiovascular morbidity and mortality. Read More

Curr Vasc Pharmacol 2019 Apr 8. Epub 2019 Apr 8.

Dipartimento di Medicina Clinica e Chirurgia, Endocrinology Unit, Federico II University Medical School of Naples. Italy.

Vitamin D and calcium are considered crucial for the treatment of bone diseases. Both vitamin D and calcium contribute to bone homeostasis but also preserve muscle health by reducing the risk of falls and fractures. Low vitamin D concentrations result in secondary hyperparathyroidism and contribute to bone loss, although the development of secondary hyperparathyroidism varies, even in patients with severe vitamin D deficiency. Read More

J R Soc Interface 2019 Feb;16(151):20180793

1 Centre for Information Services and High Performance Computing , TU Dresden, 01062 Dresden , Germany.

The present study deals with the characterization of bone quality in a sheep model of postmenopausal osteoporosis. Sheep were sham operated ( n = 7), ovariectomized ( n = 6), ovariectomized and treated with deficient diet ( n = 8) or ovariectomized, treated with deficient diet and glucocorticoid injections ( n = 7). The focus of the study is on the microscopic properties at tissue level. Read More

J R Soc Interface 2019 Feb;16(151):20180638

1 Institute of Physical Chemistry, Justus-Liebig-University Giessen , Heinrich-Buff-Ring 17, 35392 Giessen , Germany.

Next-generation bone implants will be functionalized with drugs for stimulating bone growth. Modelling of drug release by such functionalized biomaterials and drug dispersion into bone can be used as predicting tool for biomaterials testing in future. Therefore, the determination of experimental parameters to describe and simulate drug release in bone is essential. Read More

Food Sci Biotechnol 2019 Apr 14;28(2):539-545. Epub 2018 Sep 14.

College of Food Science and Engineering, Ocean University of China, Qingdao, 266003 Shandong Province China.

Glucocorticoids are the leading cause of secondary osteoporosis. In the current study, the in vivo effects of Antarctic krill () oil (AKO) on dexamethasone-treated mice were investigated. Results showed that AKO significantly prevents bone loss, as evidenced by improved bone mineral density, biomechanical strength, and cancellous bone microstructure. Read More

Osteoporos Int 2019 Apr 6. Epub 2019 Apr 6.

Radius Health, Inc., Waltham, MA, USA.

This network meta-analysis assessed the efficacy of abaloparatide versus other treatment options to reduce the risk of fractures in women with postmenopausal osteoporosis. The analysis indicates that abaloparatide reduces the risk of fractures in women with postmenopausal osteoporosis versus placebo and compared with other treatment options.

Introduction: This network meta-analysis (NMA) assessed the relative efficacy of abaloparatide versus other treatments to reduce the risk of fractures in women with postmenopausal osteoporosis (PMO). Read More

J Nutr Health Aging 2019 ;23(4):378-380

Paul Le Floch, CHRU de Brest, Brest, France,

Objective: To evaluate the prescription of bisphosphonates in female nursing home residents aged 75 and older with a history of proximal femoral fracture.

Design: Observational descriptive study, led in Brest, France, between June and August 2015.

Setting: 12 nursing homes in Brest, France. Read More

Arch Osteoporos 2019 Mar 29;14(1):44. Epub 2019 Mar 29.

Department of Orthopaedic and Trauma Surgery, Cantonal Hospital Lucerne, Spitalstrasse, Lucerne, 6000, Switzerland.

Introduction: Minor trauma fractures (MTF) in the elderly are associated with an increase in mortality, morbidity, and the risk of subsequent fractures. Often, these patients who sustain MTF have an underlying bone disease, such as osteopenia or osteoporosis. Osteoporosis is known to be underdiagnosed and undertreated, and adequate treatment is essential to reduce the occurrence of MTFs. Read More

Medicine (Baltimore) 2019 Mar;98(13):e15033

Rationale: Cases of adrenocortical hyperfunction combined with primary aldosteronism have been reported in the literature, and the underlying mechanism involves the secretion of aldosterone and glucocorticoids by a tumor or an adenoma. However, adrenocortical hypofunction and coexisting primary aldosteronism have not been reported until now. Herein, we report a case of adrenocortical hypofunction combined with primary aldosteronism. Read More

J Obstet Gynaecol Res 2019 Mar 26. Epub 2019 Mar 26.

Department of Obstetrics and Gynecology, Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, Tokyo, Japan.

Coexistence of Mayer-Rokitansky-Küster-Hauser syndrome and gonadal dysgenesis is extremely rare, and a case of Mayer-Rokitansky-Küster-Hauser syndrome with a uterine cervix and normal vagina has not been reported. Here, we report such a case associated with gonadal dysgenesis. A 17-year-old female presented with primary amenorrhea and undeveloped secondary sexual characteristics. Read More

Eurasian J Med 2019 Feb 30;51(1):38-41. Epub 2018 Nov 30.

Ankara Children's Hematology and Oncology Hospital, Ankara, Turkey.

Objective: Bone mineral density (BMD) in children may be negatively affected by acute lymphoblastic leukemia (ALL) or its treatment protocol. The aim of our study was to evaluate bone health by measuring BMD after ALL treatment.

Materials And Methods: The age, anthropometric measurements, and lumbar spine BMDs were recorded in 39 pediatric survivors of ALL, with no history of relapse, secondary malignancy, or transplantation. Read More

Ren Fail 2019 Nov;41(1):88-97

a Division of Kidney Center , Matsuyama Red Cross Hospital , Matsuyama , Japan.

Background: Eldecalcitol (ELD) is an active vitamin D analog that is widely used in Japan for the treatment of osteoporosis. The most common adverse drug reaction of ELD is hypercalcemia. However, few reports have focused on acute kidney injury (AKI) associated with ELD-induced hypercalcemia. Read More

Bone 2019 Mar 21;123:67-75. Epub 2019 Mar 21.

Department of Neurology, Rigshospitalet Glostrup, Valdemar Hansens vej 1-23, 2600 Glostrup, Denmark.

Aim: Patients with epilepsy frequently develop hyponatremia due to the treatment with antiepileptic drugs and have an increased risk of developing metabolic bone disease. Hyponatremia is known to be associated with osteoporosis. The aim of the study was to investigate the association between hyponatremia and osteoporosis in patients with epilepsy. Read More

Mol Med Rep 2019 May 21;19(5):4091-4100. Epub 2019 Mar 21.

Department of Orthopedics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.

Alzheimer's disease (AD) and osteoporosis (OP) are 2 common progressive age‑associated diseases, primarily affecting the elderly worldwide. Accumulating evidence has demonstrated that patients with AD are more likely to suffer from bone mass loss and even OP, but whether it is a pathological feature of AD or secondary to motor dysfunction remains poorly understood. The present study aimed to investigate whether amyloid‑β1‑42 (Aβ1‑42), the typical pathological product of AD, exhibited a negative effect on the proliferation of bone marrow mesenchymal stem cells (BMSCs) and the role of autophagy. Read More

Clinics (Sao Paulo) 2019 Mar 14;74:e739. Epub 2019 Mar 14.

Department of Biostatistics and Medical Informatics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.

Objective: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated.

Method: DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. Read More

Phytomedicine 2019 Feb 25;58:152874. Epub 2019 Feb 25.

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, PR China. Electronic address:

Background: The fruits of Psoralea corylifolia L. (Fructus Psoraleae, FP) has a long history and a wide range of applications in the treatment of osteoporosis and leukoderma. Although it is well known that FP could cause hepatotoxicity and reproductive toxicity, less is known about its potential toxicity on multiple organs. Read More

J Intern Med 2019 Mar 18. Epub 2019 Mar 18.

Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Background: We recently reported that the administration of zoledronate every 18 months to osteopenic older women reduces the incidence of fractures.

Objective: Here, we present a more detailed analysis of that trial to determine whether baseline clinical characteristics impact on the anti-fracture efficacy of this intervention.

Methods: This is a prospective, randomized, placebo-controlled, double-blind trial in osteopenic postmenopausal women aged ≥ 65 years, to determine the anti-fracture efficacy of zoledronate. Read More

Geriatr Orthop Surg Rehabil 2019 11;10:2151459319828618. Epub 2019 Mar 11.

Department of Orthopaedic Surgery, Virginia Commonwealth University, Richmond, VA, USA.

Introduction: Approximately 320 000 fragility hip fractures are sustained in the United States annually, resulting in substantial morbidity and mortality as well as significant economic burden on the health-care system. Nevertheless, a majority of these patients are not screened and do not receive treatment for osteoporosis. The objective of this study was to evaluate rates of osteoporosis screening and treatment in our institution and compare them to those reported in the literature. Read More

Orthop Surg 2019 Mar 10. Epub 2019 Mar 10.

Editorial Office of Orthopaedic Surgery, Tianjin Hospital, Tianjin, China.

Objective: To evaluate the efficacy of Jintiange capsules and Jintiange combined with other therapies in the treatment of osteoporosis.

Methods: A systematic review of the literature was conducted through databases including China National Knowledge Infrastructure (CNKI), the VIP Database for Chinese Technical Periodicals (VIP), Wanfang, and PubMed from inception to April 2018. Network meta-analysis was used to determine the relative efficacy of related treatments on osteoporosis. Read More

BMJ Case Rep 2019 Mar 8;12(3). Epub 2019 Mar 8.

School of Medicine, University of Notre Dame, Fremantle, Western Australia, Australia.

A 62-year-old man presented to the Emergency Department with dyspnoea and central pleuritic chest pain radiating posteriorly to between the scapulae. His medical history included hypertension, osteoporosis and chronic kidney disease secondary to focal segmental glomerulosclerosis with relapsing nephrotic syndrome. Significant examination findings included a loud palpable P2 and a displaced apex beat. Read More

JAMA Netw Open 2019 Mar 1;2(3):e190429. Epub 2019 Mar 1.

Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.

Importance: Deaths from cancer are attributed more to secondary than primary tumors, but the pathogenesis of organ-specific cancer metastasis has not been determined.

Objective: To investigate whether precancer osteoporosis and osteoporosis therapy are associated with alteration of bone metastasis patterns.

Design, Setting, And Participants: This nationwide retrospective cohort study was performed from January 1, 2002, to December 31, 2013, using 2 cohorts from the Taiwan National Health Insurance Research Database: a random sample of 1 million beneficiaries from the Longitudinal Health Insurance Database who were enrolled in 2005 (LHID2005) and a specific data set of all the patients with osteoporosis. Read More

Injury 2019 Feb 27. Epub 2019 Feb 27.

Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Naples, Italy.

Introduction: Humeral shaft is a common site of fracture non-union. Biology and bone quality represent some of the problems that the orthopaedic surgeon has to face up in the elderly. The goals of treatment of humeral shaft non-union are the achievement of mechanical stability and creation of a favourable biologic environment. Read More

BMJ Open 2019 Mar 3;9(3):e024376. Epub 2019 Mar 3.

School of Medicine, University of Sunderland, Sunderland, UK.

Objective: To explore the impact of medication-related osteonecrosis of the jaw (MRONJ) on quality of life and to explore the attitudes and perceptions of patients towards the multidisciplinary approach to the prevention of the condition.

Design: Interpretivist methodology using qualitative semistructured interviews.

Setting: Primary care general medical practices and secondary care dental services in England. Read More

Obes Surg 2019 Feb 28. Epub 2019 Feb 28.

Researcher of the NPqM at Federal University of Rio de Janeiro, (UFRJ), Rio de Janeiro, Brazil.

Objective: To compare the bone metabolism of adolescents and adults with obesity before undergoing a Roux-en-Y gastric bypass (RYGB) and 6 and 12 months after the surgery.

Materials And Methods: Adolescents (G1) and adults (G2) with obesity assessed before (T0), six (T1), and 12 months after (T2) RYGB. Sun exposure, serum concentrations of 25(OH)D, calcium, phosphorous, magnesium, zinc, alkaline phosphatase, parathyroid hormone (PTH), and bone mineral density (BMD) were evaluated. Read More

Arch Osteoporos 2019 Feb 28;14(1):27. Epub 2019 Feb 28.

Department of Kinesiology, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada.

This study of women with a suspected vertebral fracture determined the association between vertebral fracture characteristics and posture. The number of fractures was associated with posture. Severity of fracture was associated with posture when adjusting for pain. Read More

Osteoporos Int 2019 Feb 28. Epub 2019 Feb 28.

Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Rue Gabrielle Perret-Gentil 4, CH - 1205, Geneva, Switzerland.

Whether in-hospital management of patients with newly identified vertebral fractures leads to a higher rate of osteoporosis medication than delayed outpatient management remains unknown. Our study showed that early osteoporosis therapy initiation in a fracture liaison service during hospital stay was a more efficacious strategy for secondary fracture prevention.

Introduction: Fracture liaison services are standard care for secondary fracture prevention. Read More

Jpn Dent Sci Rev 2019 Nov 15;55(1):51-57. Epub 2019 Feb 15.

Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan.

It is not yet known why anti-resorptive agent-related osteonecrosis specifically affects the jaw. Here we assessed changes in the bone metabolism of the mandible in response to long-term bisphosphonate (BP) therapy, and we compared the bone metabolism changes of the mandible with those of other bone sites using a quantitative analysis by bone scintigraphy. The region of interest was selected by identifying without an abnormal accumulation of the mandible, humerus, second and fourth lumbar vertebrae, iliac crest, intertrochanteric femur and diaphysis. Read More

Exp Clin Endocrinol Diabetes 2019 Feb 27;127(2-03):171-177. Epub 2019 Feb 27.

Medizinische Klinik IV, Klinikum der Universität München, München.

The introduction of newborn screening programmes in most Western countries for classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) enables timely introduction of life-saving glucocorticoid replacement in affected babies. Early diagnosis and optimised pediatric care not only successfully led to survival but also allow that almost all patients reach adulthood. Cohort studies in adults, however, provided evidence for significant health problems and co-morbidities of adult patients such as life-threatening adrenal crises, cardiovascular and metabolic health problems, fertility problems, benign endocrine tumours, and osteopenia and osteoporosis. Read More

Am J Ophthalmol Case Rep 2019 Jun 9;14:21-25. Epub 2019 Jan 9.

Byers Eye Institute, Stanford University, Palo Alto, CA, USA.

Purpose: To report a case of presumed bilateral chorioretinitis secondary to alendronate therapy.

Observations: A 71-year-old female presented to the clinic in July 2017 with six months history of difficulty in reading along with floaters in both eyes which were more severe in the right eye. Past medical and surgical history revealed a history of hypertension, gout, hyperthyroidism, osteoporosis, and humerus fracture. Read More

Arch Orthop Trauma Surg 2019 Feb 25. Epub 2019 Feb 25.

Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria.

Introduction: Cement augmentation of the proximal humerus internal locking system (PHILOS) screws might reduce complication rates in osteoporotic bones. This study compared the risk of mechanical failure during the first year after PHILOS™ treatment of proximal humerus fractures (PHF) without (control group) and with (augmented group) screw augmentation. Secondary objectives were to report shoulder functions, quality of life (QoL), adverse events (AEs), and reoperation rates. Read More

Lancet Oncol 2019 Mar 19;20(3):339-351. Epub 2019 Feb 19.

Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria; Department of Gynaecology and Obstetrics, Medical University of Vienna, Vienna, Austria.

Background: In postmenopausal women with hormone receptor-positive, early-stage breast cancer, treatment with adjuvant aromatase inhibitors is the standard of care, but it increases risk for osteoporosis and fractures. Results from the ABCSG-18 trial showed that use of denosumab as an adjuvant to aromatase inhibitor therapy significantly reduced clinical fractures. Disease-free survival outcomes from ABCSG-18 have not yet been reported. Read More

Osteoporos Sarcopenia 2018 Dec 1;4(4):128-133. Epub 2018 Dec 1.

Department of Orthopedic Surgery, Akita University Graduate School of Medicine, Akita, Japan.

Objectives: Rheumatoid arthritis (RA) is characterized by chronic inflammation of the synovium, progressive erosion of the articular cartilage, and joint destruction. RA also causes secondary osteoporosis and muscle wasting. We investigated the effects of ibandronate (IBN), a bisphosphonate; eldecalcitol (ELD), an active vitamin D3 derivative; and combination treatment with both agents on secondary osteoporosis and muscle wasting using adjuvant-induced arthritis rats. Read More

Osteoporos Sarcopenia 2018 Jun 7;4(2):47-52. Epub 2018 Jun 7.

Superintendent Office, National Taiwan University Hospital Chu-Tung Branch, Hsinchu County, Taiwan.

Osteoporosis and its associated fragility fractures are becoming a severe burden in the healthcare system globally. In the Asian-Pacific (AP) region, the rapidly increasing in aging population is the main reason accounting for the burden. Moreover, the paucity of quality care for osteoporosis continues to be an ongoing challenge. Read More

Acta Ortop Bras 2018 ;26(6):384-387

Department of Orthopedics and Traumatology, Santa Casa de Sao Paulo, SP, Brazil.

Objectives: To determine the proportion of traumatologists who investigate osteoporosis in elderly patients with fractures and recommend secondary prevention of osteoporotic fractures.

Methods: We distributed questionnaires to 244 physicians attending the 2015 Brazilian Congress of Orthopedic Trauma. We determined the respondents' profiles and assessed how they investigated and treated osteoporosis in elderly patients with fractures. Read More

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):766-769

Department of Endocrinology, AIIMS, New Delhi, India.

Introduction: Osteoporosis is a well-recognized complication of Cushing's syndrome (CS). Data on bone health in patients with CS from south Asian countries, which are vitamin D deficient, are scarce.

Aims: We assessed bone mineral density (BMD) in patients with CS in comparison to controls. Read More

J Int Med Res 2019 Apr 14;47(4):1610-1619. Epub 2019 Feb 14.

7 Department of Orthopaedics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Objective: To compare medium-term clinical and radiological outcomes of primary unilateral uncemented (UN) or cemented (CE) femoral component total hip arthroplasty (THA) in elderly patients with osteoporosis.

Methods: Consecutive patients with osteoporosis who underwent primary unilateral UN or CE THAs at our institution from 2006 to 2013 were retrospectively reviewed. All consecutive procedures were managed by high-volume surgeons, using UN or CE THA approaches. Read More

Arch Osteoporos 2019 Feb 12;14(1):19. Epub 2019 Feb 12.

CIUSSS Nord de l'Ile de Montréal, Hôpital du Sacré-Coeur de Montréal, 5400 bl. Gouin ouest, Montreal, QC, H4J 1C5, Canada.

The study design of a multidisciplinary Fracture Liaison Service (2-year follow-up) aiming to optimize fragility fracture management in an outpatient setting is presented. Patient characteristics, investigation, and treatment initiation data at baseline were recorded. Results corroborate the care gap in osteoporosis management, reinforcing the need for secondary fracture prevention programs. Read More

Hip Int 2018 Nov;28(2_suppl):78-83

1 I.R.C.C.S. - Istituto Ortopedico Rizzoli, Bologna, Italy.

Introduction:: Hip fractures represent an enormous challenge for our health care system. The aim of this randomised controlled trial was to assess both efficacy and safety of a novel device called Prevention Nail System (PNS) and developed for the surgical prevention of a contralateral femoral neck fracture (FNF) in elderly osteoporotic patients.

Methods:: Primary outcome was to evaluate, in patients suffering from osteoporotic FNF, the effectiveness of PNS in reducing the incidence of a contralateral hip fracture. Read More

J Endocr Soc 2019 Feb 4;3(2):411-426. Epub 2019 Jan 4.

Division of Endocrinology and Metabolism, Georgetown University Medical Center, Washington, District of Columbia.

Context: Patients with diabetes mellitus are at increased risk for bone fragility fracture secondary to multiple mechanisms. Hyperglycemia can induce true dilutional hyponatremia. Hyponatremia is associated with gait instability, osteoporosis, and increased falls and bone fractures, and studies suggest that compromised bone quality with hyponatremia may be independent of plasma osmolality. Read More

Front Psychiatry 2018 28;9:781. Epub 2019 Jan 28.

Mental Health Centre Glostrup, Copenhagen University Hospital, Glostrup, Denmark.

Low bone mineral density (BMD) may constitute an underestimated comorbidity in schizophrenia patients undergoing long-term antipsychotic treatment. Glucagon-like peptide 1 (GLP-1) receptor agonists are antidiabetic drugs, which may also affect bone turnover. In planned secondary analyses of a 3 months, double-blind, randomized, placebo-controlled trial ( = 45), we explored effects of the GLP-1 receptor agonist exenatide 2 mg once-weekly ( = 23), or placebo ( = 22) on bone turnover markers (BTMs) and BMD in chronic, obese, antipsychotic-treated patients with schizophrenia spectrum disorder. Read More

J Clin Med 2019 Feb 6;8(2). Epub 2019 Feb 6.

Department of Orthopaedics, Graduate School, Tokyo Medical and Dental University, Tokyo 108-0075, Japan.

While bracing is the standard conservative treatment for acute osteoporotic compression fracture, the efficacy of different brace treatments has not been extensively studied. We aimed to clarify and compare the preventive effect of the different brace treatments on the deformity of the vertebral body and other clinical results in this patient cohort. This multicenter nationwide prospective randomized study included female patients aged 65⁻85 years with acute one-level osteoporotic compression fractures. Read More

Expert Rev Endocrinol Metab 2019 Mar 8;14(2):111-122. Epub 2019 Feb 8.

a Department of Internal Medicine and Medical Disciplines , "Sapienza" University of Rome , Rome , Italy.

Introduction: The term secondary osteoporosis (SO) identifies a reduction of bone mass related to a well-established disease or pharmacological agent. The identification of the underlying disease often represents a challenging situation in clinical practice. Areas covered: The prevalence of SO in the real world may vary, ranging from 17% to 80%; therefore, search for a form of SO represents a pillar when evaluating patients with osteoporosis. Read More

Methods Mol Biol 2019 ;1914:571-616

Dental Physical Sciences, Biophysics Section, Oral Growth and Development, Dental Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

This chapter describes methods for preparing samples of bone and bone cells for scanning electron microscopy (SEM). Backscattered electron (BSE) imaging is by far the most useful in the bone field, followed by secondary electrons (SE) and the energy dispersive X-ray (EDX) analytical modes. Samples may have 3D detail in a 3D surface, or be topography-free, polished or micromilled, resin-embedded block surfaces, or resin casts of space compartments surrounded by bone matrix. Read More