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Curr Opin Endocrinol Diabetes Obes 2022 Jun 27. Epub 2022 Jun 27.

Department of Medicine (C5121), University of Manitoba, Winnipeg, Manitoba, Canada.

Purpose Of Review: Type 1 (T1D) and 2 diabetes (T2D) are associated with increased risk of fracture independent of bone mineral density (BMD). Fracture risk prediction tools can identify individuals at highest risk, and therefore, most likely to benefit from antifracture therapy. This review summarizes recent advances in fracture prediction tools as applied to individuals with diabetes. Read More

Acta Endocrinol (Buchar) 2021 Oct-Dec;17(4):537-542

University of California San Diego, La Jolla, California, United States of America.

We describe clinical features of women with extremely low bone density, and investigate secondary causes of osteoporosis. Our hypothesis was that this population would be enriched in identifiable causes of osteoporosis. We performed a retrospective review of medical records of all women seen at our university over 4 years with T-score on bone densitometry at/below -4 at any site. Read More

Medicina (Kaunas) 2022 Jun 8;58(6). Epub 2022 Jun 8.

Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 62247, Taiwan.

: To study the risk of spine surgery, including cervical and lumbar spine surgeries in patients with rheumatoid arthritis (RA) compared with those without a diagnosis of RA. : This is a secondary data analysis using population-based health claim data. We identified newly diagnosed adult patients with RA between January 2000 and December 2012, according to the International Classification of Diseases, Ninth revision, clinical modification code 714. Read More

Best Pract Res Clin Rheumatol 2022 Jun 20:101757. Epub 2022 Jun 20.

VA Puget Sound Health Care System, 1660 South Columbian Way, S-151-A, Seattle, WA, 98108, USA; University of Washington Department of Medicine, 1959 NE Pacific St. Box 356428 Seattle, WA 98195-6428, USA. Electronic address:

In this chapter, we emphasize among rheumatoid arthritis (RA) patients, whom and how to screen for osteoporosis. We highlight certain modalities, advancements in technology, secondary osteoporosis workup, and laboratory testing as well as their caveats. Finally, we discuss current guidance on how to direct the laboratory and radiology testing in the context of the individual patient with RA to guide and select from the osteoporosis treatment options currently available. Read More

N Z Med J 2022 Jun 10;135(1556):73-80. Epub 2022 Jun 10.

Endocrinologist & General Physician, Department of Endocrinology, Waitematā District Health Board, Auckland, New Zealand.

Aim: To describe the service delivery of the Fracture Liaison Service (FLS) at Waitematā District Health Board (WDHB) for the year 2020, and to outline how the service evolved in recent years.

Method: We reviewed and analysed the WDHB FLS database as well as 4-month and 12-month patient follow-up records from the calendar year 2020.

Results: In 2020, we identified and assessed 1,225 patients. Read More

J Cell Mol Med 2022 Jun 21. Epub 2022 Jun 21.

Department of Pathology, General Hospital of Northern Theater Command, Shenyang, China.

Diabetic osteoporosis is secondary osteoporosis and a serious complication of diabetes with a high incidence rate and poor prognosis. The specific mechanism of diabetic osteoporosis is unclear, and prevention and treatment options are limited. Recently, melatonin has been found to prevent and treat diabetic osteoporosis. Read More

J Allergy Clin Immunol Pract 2022 Jun 17. Epub 2022 Jun 17.

Division of Allergy and Clinical Immunology, University of Salerno, Italy.

Indolent systemic mastocytosis (ISM) has a favorable prognosis and normal life expectancy. However, many patients suffer from mast cell (MC) mediator-related symptoms, which significantly affect quality of life (QoL). Cutaneous, gastrointestinal and neurological complaints, musculoskeletal pain as well as the presence of skin lesions, anaphylaxis and osteoporosis are the main symptoms and signs in ISM and must be assessed in all patients before and during treatment. Read More

Front Oral Health 2022 20;3:903154. Epub 2022 May 20.

Division of Oral Medicine and Dentistry, Brigham and Women's Hospital and Dana Farber Cancer Institute Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, United States.

Chronic oral graft-versus-host disease (cGVHD) is a complex, frequent, and highly impactful complication of allogeneic hematopoietic cell transplantation (alloHCT). It represents the leading cause of morbidity and mortality in long-term alloHCT survivors. cGVHD can affect almost any visceral organ system and commonly affects the skin, eyes and mouth, manifesting with signs and symptoms similar to other known immune-mediated and autoimmune diseases. Read More

Pharmacotherapy 2022 Jun 18. Epub 2022 Jun 18.

Department of Pharmacy, Okayama Saiseikai General Hospital, Japan.

Background: Several reports suggest that adverse events caused by ibandronate are less serious than those associated with the other bisphosphonates. The purpose of this systematic review and meta-analysis was to determine whether ibandronate has low rates of serious adverse events and kidney injury.

Methods: Randomized controlled trials were selected, and the study populations consisted of adult patients with osteoporosis. Read More

Iran J Kidney Dis 2022 May;16(3):203-208

Department of Maxillofacial Radiology, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran.

Introduction: This study aimed to investigate the relationship between serum levels of PTH and dental and bone changes in the panoramic view of hemodialysis patients.

Methods: Out of 236 patients with end-stage kidney disease (ESKD) who were hospitalized in two hemodialysis centers, 68 ones were selected and concerning their PTH serum levels, they were assigned to case group (PTH > 300 pg/mL) and control group (150 < PTH < 300 pg/mL). Patients in both groups had undergone dialysis for at least 6 months. Read More

Singapore Med J 2022 06 16. Epub 2022 Jun 16.

Department of Endocrinology, Changi General Hospital, Singapore.

Introduction: A significant treatment gap has been observed in patients with osteoporosis. Our previous audit found a 31.5% rate of anti-osteoporosis medication initiation after fragility fractures at one year. Read More

Osteoporos Int 2022 Jun 15. Epub 2022 Jun 15.

Department of Nursing, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

The effectiveness of home-based resistance exercise in elder participants with osteoporosis remains unclear. This study demonstrates the beneficial effects of this mode of exercise on improving physical function, increasing confidence in exercise, and reducing fear of falling.

Introduction: This study aims to evaluate the effect of a home-based resistance exercise (HBRE) program versus control on physical function, exercise self-efficacy, falling efficacy, and health-related quality of life (HRQOL). Read More

Rambam Maimonides Med J 2022 Jun 12. Epub 2022 Jun 12.

Department of Family Medicine, University of Health Sciences, Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.

Objectives: Anti-osteoporotic drugs (AOD) are essential for secondary prevention of osteoporotic fracture (OF) in patients with established osteoporosis. However, data about AOD utilization rates are scarce among patients with OF. This study was therefore aimed at determining the AOD utilization rates among those particularly vulnerable patients. Read More

Cureus 2022 May 10;14(5):e24896. Epub 2022 May 10.

Orthopedics, Government Medical College, Amritsar, IND.

Background Intertrochanteric fractures are common injuries among the elderly population and those with osteoporosis. The study was conducted in order to evaluate the outcome of Proximal Femoral Nail Antirotation II (PFN-A2) in the treatment of these fractures in elderly patients. Methods Twenty-five elderly patients (range 60 to 73 years) with trochanteric fractures who were treated with PFN-A2 at Government Medical College Amritsar were included in this prospective observational study. Read More

Bone Rep 2022 Jun 3;16:101595. Epub 2022 Jun 3.

Department of Pediatrics and Adolescent Medicine, Johannes Kepler University Linz, Linz, Austria.

Background: Vertebral compression fractures (VFs) are a common and severe finding in patients with osteoporosis. In children, VFs have the unique potential to reshape and regain their original configuration. Spontaneous vertebral body reshaping (, medication-unassisted) has been reported in secondary osteoporosis. Read More

Best Pract Res Clin Rheumatol 2022 Jun 9:101754. Epub 2022 Jun 9.

MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton General Hospital, Southampton, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospitals Southampton NHS Foundation Trust, Southampton, UK. Electronic address:

Osteoporosis care has evolved markedly over the last 50 years, such that there are now an established clinical definition, validated methods of fracture risk assessment, and a range of effective pharmacological agents. However, it is apparent that both in the context of primary and secondary fracture prevention, there is a considerable gap between the population at high fracture risk and those actually receiving appropriate antiosteoporosis treatment. In this narrative review article, we document recent work describing the burden of disease, approaches to management, and service provision across Europe, emerging data on gaps in care, and existing/new ways in which these gaps may be addressed at the level of healthcare systems and policy. Read More

J Bone Miner Res 2022 Jun 11. Epub 2022 Jun 11.

Division of Nephrology and Endocrinology, The University of Tokyo Hospital, Tokyo, Japan.

Context: Tumor-induced osteomalacia (TIO) is an acquired fibroblast growth factor 23 (FGF23)-related hypophosphatemic osteomalacia caused by phosphaturic mesenchymal tumors (PMTs) developed in the bone or soft tissue. Diagnostic delay should be addressed, and ideal techniques to localize PMTs and efficient treatment options should be explored to improve the outcomes of this rare disease.

Objective: To clarify the detailed clinical course and outcomes of TIO patients. Read More

Osteoporos Int 2022 Jun 11. Epub 2022 Jun 11.

Clinical Pharmacy, Aston University, Birmingham, UK.

Systematic reviews that examine effectiveness of interventions to improve medicines optimisation do not explain how or why they work. This realist review identified that interventions which effectively optimise medicines use in osteoporosis include opportunities to address patients' perceptions of illness and treatment and/or support primary care clinician decision making.

Introduction: In people with osteoporosis, adherence to medicines is poorer than other diseases and patients report follow-up is lacking, and multiple unmet information needs. Read More

Bone 2022 Jun 8;162:116455. Epub 2022 Jun 8.

Department of Endocrinology, Changi General Hospital, Singapore.

Introduction: Studies have found that not all atypical femoral fractures (AFF) are associated with bisphosphonate (BP) use. There are limited data on AFF in non-BP patients. In this study, we characterise factors associated with BP and non-BP related AFF and its mortality in a single centre in Singapore. Read More

Medicine (Baltimore) 2022 Jun 10;101(23):e28253. Epub 2022 Jun 10.

Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar.

Introduction: There are variable complications of hyperthyroidism, including atrial fibrillation, heart failure, osteoporosis, and thyroid storm. One infrequent complication of hyperthyroidism is non-diabetic ketoacidosis (NDKA). To the best of our knowledge, our case is the third report of NDKA related to thyrotoxicosis. Read More

Spine J 2022 Jun 6. Epub 2022 Jun 6.

University of Wisconsin School of Medicine and Public Health, UW Medical Foundation Centennial Building, Department of Orthopedics & Rehabilitation, 1685 Highland Avenue, 6(th) Floor, Madison, WI 53705, United States of America. Electronic address:

Background Context: Normal bone mineral density (BMD) as measured by dual-energy x-ray absorptiometry (DXA) is present in approximately 10% of older adults with fracture. BMD alone does not evaluate bone quality or clinical risk factors, and therefore, may not adequately capture a patient's fracture risk. Thus, despite a normal DXA-measured BMD, the underlying bone may be abnormal, suggesting that further bone health evaluation, and potentially, pharmacologic treatment may be warranted. Read More

Praxis (Bern 1994) 2022 ;111(8):475-481

Medbase St. Gallen Am Vadianplatz, St. Gallen, Schweiz.

A Distal Radius Fracture Is Not Simply a Distal Radius Fracture We report on a 57-year-old female patient with a distal extra-articular radius fracture. The family doctor's suspicion was an osteoporosis-associated fracture, and an interdisciplinary investigation was initiated. In addition to DXA measurement differential diagnoses for secondary osteoporosis were considered. Read More

J Diabetes Metab Disord 2022 Jun 25;21(1):1139-1148. Epub 2022 May 25.

Diabetes Research Center, Endocrinology and Metabolism Clinical sciences Institute, Tehran University of Medical Sciences, PO Box: 1411413137, Tehran, Iran.

Background: Mapping the available evidence can be used to inform current diabetes research, identify relevant gaps, and prioritize future research. In this regard, we mapped diabetes research performed in Iran.

Method: We searched the Scopus and PubMed databases from 01/01/2015 till 01/01/2020 using keywords such as diabetes and Iran. Read More

Osteoporos Int 2022 Jun 7. Epub 2022 Jun 7.

Department of Orthopaedic Surgery, Tulane University School of Medicine, New Orleans, LA, USA.

This study highlights the persistent osteoporosis treatment gap following fragility fractures. Patients with multiple sclerosis sustained more primary hip fractures than controls and exhibited significantly higher rates of falls within three years post-fracture. However, multiple sclerosis (MS) patients were significantly more likely to be diagnosed with osteoporosis and treated with medications. Read More

Front Endocrinol (Lausanne) 2022 20;13:882241. Epub 2022 May 20.

Department of Endocrinology and Metabolism, the Second Affiliated Hospital of ZheJiang University School of Medicine, Hangzhou, China.

Background: Low bone mineral density (LBMD), including osteoporosis and low bone mass, has becoming a serious public health concern. We aimed to estimate the disease burden of LBMD and its related fractures in 204 countries and territories over the past 30 years.

Methods: We collected detailed information and performed a secondary analysis for LBMD and its related fractures from the Global Burden of Disease Study 2019. Read More

Front Surg 2022 18;9:842978. Epub 2022 May 18.

Department of Orthopedics and Traumatology, Beijing Jishuitan Hospital, Beijing, China.

Background: Geriatric hip fracture is one of the most common end-stage events in older patients with osteoporosis. We aimed to improve the original co-management process by engaging emergency physicians in the preoperative multidisciplinary management team (MDT). We evaluated this intervention in terms of reducing patient waiting time before surgery. Read More

Injury 2022 Jul 21;53(7):2454-2461. Epub 2022 May 21.

Department of Orthopedics, Ramathibodi Hospital, 270, Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand.

Background: Periprosthetic femoral fracture (PFF) is well-known complication in cementless hip arthroplasty (HA), especially in the elderly with osteoporosis. To prevent intraoperative PFFs during HA, prophylactic cerclage wiring on the calcar area during femoral broaching and implant insertion is recommended. However, biomechanical data on the benefits of cerclage wiring in osteoporotic bone during impaction are limited and controversial. Read More

Zhonghua Fu Chan Ke Za Zhi 2022 May;57(5):346-351

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China.

To verify the efficacy and safety of daily oral minodronate in postmenopausal women with established osteoporosis. In this randomized, double-blinded, placebo-controlled trial, 262 postmenopausal women were enrolled. Patients were randomized to receive daily oral minodronate 1 mg with supplements of 500 mg calcium and 200 U vitamin D (=130) or placebo (=132) with daily supplements of 500 mg calcium and 200 U vitamin D, for 48 weeks. Read More

PLoS One 2022 3;17(6):e0269335. Epub 2022 Jun 3.

Division of Preventive Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Japan.

Background: Bone metastases in breast cancer patients are a common concern for medical doctors and dentists. Bone-modifying agents, which are necessary to prevent skeletal-related events (SREs), are associated with osteonecrosis of the jaw as an adverse side effect. Hypersensitivity to alcohol is an unfavorable response caused by deficiency of aldehyde dehydrogenase-2 (ALDH2) activity. Read More

J Med Cases 2022 May 7;13(5):244-248. Epub 2022 May 7.

Department of Medicine, Cooper Medical School of Rowan University - Cooper University Health Care, Camden, NJ, USA.

Selective androgen receptor modulators (SARMs) are compounds that bind to androgen receptors and have similar anabolic properties to anabolic steroids. Unlike anabolic steroids, which bind to androgen receptors in many tissues all over the body, individual SARMs selectively bind androgen receptors in certain tissues, but not in others. This selectivity has attracted researchers due to the possibility of using SARMs for the potential benefits of androgen receptor stimulation, such as increased muscle mass and increased bone density, while minimizing the adverse effects, such as erythrocytosis and hepatotoxicity. Read More