7,155 results match your criteria Osteoporosis Primary


Evaluation of endothelial function and diastolic function in patients with primary hyperparathyroidism before and after parathyroidectomy.

Cir Cir 2019 ;87(2):196-204

Unidad de Investigación en Endocrinología Experimental. Hospital de Especialidades Centro Médico Nacional Siglo XXI. Ciudad de México, México.

Introduction: Primary hyperparathyroidism (PHPT) is the leading cause of outpatient hypercalcemia associated with increased cardiovascular risk. The flow-mediated vasodilation (FMV) has been proposed as a non-invasive method for assessing endothelial function.

Objective: To compare the endothelial dysfunction measured by FMV and diastolic dysfunction in patients with PHPT before and after parathyroidectomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.24875/CIRU.18000520DOI Listing
January 2019

Cemented versus uncemented femoral component total hip arthroplasty in elderly patients with primary osteoporosis: retrospective analysis with 5-year follow-up.

J Int Med Res 2019 Feb 14:300060518825428. Epub 2019 Feb 14.

7 Department of Orthopaedics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Objective: To compare medium-term clinical and radiological outcomes of primary unilateral uncemented (UN) or cemented (CE) femoral component total hip arthroplasty (THA) in elderly patients with osteoporosis.

Methods: Consecutive patients with osteoporosis who underwent primary unilateral UN or CE THAs at our institution from 2006 to 2013 were retrospectively reviewed. All consecutive procedures were managed by high-volume surgeons, using UN or CE THA approaches. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300060518825428DOI Listing
February 2019

Zebrafish as an Emerging Model for Osteoporosis: A Primary Testing Platform for Screening New Osteo-Active Compounds.

Front Endocrinol (Lausanne) 2019 29;10. Epub 2019 Jan 29.

School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University of Bristol, Bristol, United Kingdom.

Osteoporosis is metabolic bone disease caused by an altered balance between bone anabolism and catabolism. This dysregulated balance is responsible for fragile bones that fracture easily after minor falls. With an aging population, the incidence is rising and as yet pharmaceutical options to restore this imbalance is limited, especially stimulating osteoblast bone-building activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2019.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361756PMC
January 2019

Surgical prevention of femoral neck fractures in elderly osteoporotic patients: a randomised controlled study on the prevention nail system device.

Hip Int 2018 Nov;28(2_suppl):78-83

1 I.R.C.C.S. - Istituto Ortopedico Rizzoli, Bologna, Italy.

Introduction:: Hip fractures represent an enormous challenge for our health care system. The aim of this randomised controlled trial was to assess both efficacy and safety of a novel device called Prevention Nail System (PNS) and developed for the surgical prevention of a contralateral femoral neck fracture (FNF) in elderly osteoporotic patients.

Methods:: Primary outcome was to evaluate, in patients suffering from osteoporotic FNF, the effectiveness of PNS in reducing the incidence of a contralateral hip fracture. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1120700018813207DOI Listing
November 2018

Both non-surgical dental treatment and extractions increase the risk of medication-related osteonecrosis of the jaw: case-control study.

Clin Oral Investig 2019 Feb 12. Epub 2019 Feb 12.

School of Dentistry and Oral Health, Griffith University, Southport, Queensland, 4222, Australia.

Objectives: Medication-related osteonecrosis of the jaws (MRONJ) is a serious condition whose risk factors remain unclear. The aim of this study is to investigate the role of oral health and of dental treatment in the development of MRONJ.

Materials And Methods: A case-control study was conducted in Brisbane, Australia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00784-019-02828-wDOI Listing
February 2019

Bone Health in Patients With Liver Diseases.

J Clin Densitom 2019 Jan 18. Epub 2019 Jan 18.

Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA USA. Electronic address:

Osteoporosis is the most common bone disease in chronic liver disease (CLD) resulting in frequent fractures and leading to significant morbidity in this population. In addition to patients with cirrhosis and chronic cholestasis, patients with CLD from other etiologies may be affected in the absence of cirrhosis. The mechanism of osteoporosis in CLD varies according to etiology, but in cirrhosis and cholestatic liver disease it is driven primarily by decreased bone formation, which differs from the increased bone resorption seen in postmenopausal osteoporosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jocd.2019.01.004DOI Listing
January 2019
1 Read

High prevalence of vertebral fractures and low trabecular bone score in patients with fragility fractures: A cross-sectional sub-study of NoFRACT.

Bone 2019 Feb 8. Epub 2019 Feb 8.

Department of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.

Purpose: Norway has among the highest incidence rates of fractures in the world. Vertebral fracture assessment (VFA) and trabecular bone score (TBS) provide information about fracture risk, but their importance have not been studied in Norwegian patients with fragility fractures. The objectives of this study were to examine the clinical characteristics of a cohort of women and men with fragility fractures, their prevalence of vertebral fractures using VFA and prevalence of low TBS, and explore the differences between the sexes and patients with and without vertebral fractures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.02.008DOI Listing
February 2019
1 Read

Comparison of Rigid and Soft-Brace Treatments for Acute Osteoporotic Vertebral Compression Fracture: A Prospective, Randomized, Multicenter Study.

J Clin Med 2019 Feb 6;8(2). Epub 2019 Feb 6.

Department of Orthopaedics, Graduate School, Tokyo Medical and Dental University, Tokyo 108-0075, Japan.

While bracing is the standard conservative treatment for acute osteoporotic compression fracture, the efficacy of different brace treatments has not been extensively studied. We aimed to clarify and compare the preventive effect of the different brace treatments on the deformity of the vertebral body and other clinical results in this patient cohort. This multicenter nationwide prospective randomized study included female patients aged 65⁻85 years with acute one-level osteoporotic compression fractures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm8020198DOI Listing
February 2019
1 Read

Adults with cerebral palsy have higher prevalence of fracture compared to adults without cerebral palsy independent of osteoporosis and cardiometabolic diseases.

J Bone Miner Res 2019 Feb 7. Epub 2019 Feb 7.

Department of Physical Medicine and Rehabilitation, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.

Individuals with cerebral palsy (CP) have increased risk of fracture throughout their lifespan due to an underdeveloped musculoskeletal system, excess body fat, diminished mechanical loading, and early development of noncommunicable diseases. However, the epidemiology of fracture among adults with CP is unknown. The purpose of this cross-sectional study was to determine the prevalence of fracture among a large sample of privately-insured adults with CP, as compared to adults without CP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbmr.3694DOI Listing
February 2019
2 Reads

Parathyroidectomy versus cinacalcet for tertiary hyperparathyroidism; a retrospective analysis.

Langenbecks Arch Surg 2019 Feb 7. Epub 2019 Feb 7.

Department of Surgery, Erasmus MC, University Medical Center Rotterdam, 's-Gravendijkwal 230, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.

Introduction: Tertiary hyperparathyroidism (tHPT), i.e., persistent HPT after kidney transplantation, affects 17-50% of transplant recipients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00423-019-01755-4DOI Listing
February 2019
1 Read

Expression of Sclerostin in Osteoporotic Fracture Patients Is Associated with DNA Methylation in the CpG Island of the Gene.

Int J Genomics 2019 8;2019:7076513. Epub 2019 Jan 8.

Key Laboratory of Orthopaedics & Traumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.

Purpose: gene is one of the key factors in regulating bone absorption. Although there are reports showing diverse transcription factors, epigenetic modification could be responsible for regulating gene expression. There is still little exploration on promoter methylation status of gene in osteoporotic bone tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/7076513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341240PMC
January 2019
1 Read

Biomarkers of Osteoporosis: An Update.

Endocr Metab Immune Disord Drug Targets 2019 02 4. Epub 2019 Feb 4.

Pharmaceutical Medicine, Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New-Delhi-10062. India.

Background: Osteoporosis, characterized by compromised bone quality and strength is associated with bone fragility and fracture risk. Biomarkers are crucial for the diagnosis or prognosis of a disease as well as elucidating the mechanism of drug action and improve decision making.

Objective: An exhaustive description of traditional markers including bone mineral density, vitamin D, alkaline phosphatase, etc along with novel potential markers such as microarchitectural determination, trabecular bone score, osteocalcin, etc. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1871530319666190204165207DOI Listing
February 2019
6 Reads

Testosterone Replacement Therapy Has Limited Effect on Increasing Bone Mass Density in Older Men: a Meta-analysis.

Curr Pharm Des 2019 Feb 6. Epub 2019 Feb 6.

Changzhi Medical College, address: No. 161, Jiefangdong Street, Changzhi, Shanxi. China.

Background: Testosterone insufficiency may play a role in age-related decreases in bone mass density (BMD) and osteoporosis in aging men. Testosterone replacement therapy (T therapy) seems to be a simple and convenient way to increase BMD and improve the condition of osteoporosis.

Objective: To evaluate the effects of T therapy in increasing BMD among older men with low serum testosterone concentrations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190206223244DOI Listing
February 2019

Paradigm shift in geriatric fracture treatment.

Eur J Trauma Emerg Surg 2019 Feb 6. Epub 2019 Feb 6.

Department of Orthopaedics and Traumatology, University Medical Center of Johannes Gutenberg-University Mainz, Mainz, Germany.

The number of geriatric patients is increasing. These patients exhibit specific characteristics, which influence the type of fracture care. Many patients have comorbidities, which make them more vulnerable to surgical procedures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00068-019-01080-xDOI Listing
February 2019
1 Read

The Skeletal Impact of Cancer Therapies.

Br J Clin Pharmacol 2019 Feb 5. Epub 2019 Feb 5.

Division of Endocrinology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, 55905.

Both cancer and therapies used in the treatment of cancer can have significant deleterious effects on the skeleton, increasing the risks for both bone loss and fracture development. While advancements in cancer therapies have resulted in enhanced cancer survivorship for patients with many types of malignancies, it is increasingly recognized that efforts to reduce bone loss and limit fractures must be considered for nearly all patients undergoing cancer therapy in order to diminish the anticipated future skeletal consequences. To date, most studies examining the impact of cancer therapies on skeletal outcomes have focused on endocrine associated cancers of the breast and prostate, with more recent advances in our understanding of bone loss and fracture risk in other malignancies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcp.13866DOI Listing
February 2019

Severe hypocalcemia following denosumab treatment in a patient with secondary osteoporosis associated with primary sclerosing cholangitis.

Endocr J 2019 Feb 2. Epub 2019 Feb 2.

Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

Primary sclerosing cholangitis (PSC) has been known as a cause of secondary osteoporosis, which often requires medication. Herein, we give the first report of a case of a 38-year-old man with fatigue and paralysis in both upper limbs who had been treated with denosumab for secondary osteoporosis associated with PSC. Since bisphosphonate (alendronate) was ineffective in our patient, the treatment was changed from alendronate to denosumab. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1507/endocrj.EJ18-0545DOI Listing
February 2019
1 Read

Clinical decision support system for the management of osteoporosis compared to NOGG guidelines and an osteology specialist: a validation pilot study.

BMC Med Inform Decis Mak 2019 Feb 1;19(1):27. Epub 2019 Feb 1.

Landspitali - University Hospital, Reykjavik, Iceland.

Background: Although osteoporosis is an easily diagnosed and treatable condition, many individuals remain untreated. Clinical decision support systems might increase appropriate treatment of osteoporosis. We designed the Osteoporosis Advisor (OPAD), a computerized tool to support physicians managing osteoporosis at the point-of-care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12911-019-0749-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359836PMC
February 2019
1 Read

Extract and fraction of Cassia occidentalis L. (a synonym of Senna occidentalis) have osteogenic effect and prevent glucocorticoid-induced osteopenia.

J Ethnopharmacol 2019 Jan 28;235:8-18. Epub 2019 Jan 28.

Division of Endocrinology, CSIR-Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow 226031, India. Electronic address:

Ethnopharmacological Relevance: Cassia occidentalis L., a synonym of Senna occidentalis (belongs to Caesalpiniaceae family) is an annual plant. Pursuing a lead from a folk practice prevalent since the late nineteenth century in Andhra Pradesh, a Southern state of India, of use of Cassia occidentalis leaf and stem for treating patients with fracture and bone diseases, we have not only confirmed its fracture healing activity but also demonstrated efficacy in preventing glucocorticoid-induced osteoporosis (GIO), the commonest form of medication-induced bone loss caused chiefly due to impairment of bone formation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.029DOI Listing
January 2019
4 Reads
2.998 Impact Factor

Vitamin D and Falls in Older African American Women: The PODA Randomized Clinical Trial.

J Am Geriatr Soc 2019 Jan 30. Epub 2019 Jan 30.

NYU Winthrop Hospital, Mineola, New York.

Background: Limited information is available on the influence of vitamin D on falls in older high-functioning black American women. Endocrine Society guidelines propose serum 25(OH)D levels over 30 ng/mL.

Objective: To determine if maintenance of serum 25(OH)D above 30 ng/mL protects against falls. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jgs.15760
Publisher Site
http://dx.doi.org/10.1111/jgs.15760DOI Listing
January 2019
5 Reads

Treatment with once-weekly alendronate oral jelly compared with once-weekly alendronate oral tablet for Japanese patients with primary osteoporosis: An open-label, prospective, observational study.

Health Sci Rep 2019 Jan 12;2(1):e107. Epub 2018 Dec 12.

Department of Orthopaedic Surgery, School of Medicine University of Occupational and Environmental Health Kitakyushu Japan.

Background And Aims: Clinical data regarding alendronate jelly are limited. We compared the efficacy and safety of once-weekly alendronate oral jelly with once-weekly alendronate tablet formulations in the context of primary osteoporosis.

Methods: In this 6-month, open-label, prospective, observational study, Japanese patients aged ≥60 years with primary osteoporosis were included from 14 primary care centres in Japan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hsr2.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346986PMC
January 2019
1 Read

Frailty and Risk of Fractures in Patients With Type 2 Diabetes.

Diabetes Care 2019 Jan 28. Epub 2019 Jan 28.

Department of Medicine, McGill University, Montréal, Québec, Canada.

Objective: We aimed to explore whether frailty was associated with fracture risk and whether frailty could modify the propensity of type 2 diabetes toward increased risk of fractures.

Research Design And Methods: Data were from a prospective cohort study. Our primary outcome was time to the first incident clinical fragility fracture; secondary outcomes included time to hip fracture and to clinical spine fracture. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/dc18-1965DOI Listing
January 2019
1 Read

Effects of denosumab and alendronate on bone health and vascular function in hemodialysis patients: A randomized, controlled trial.

J Bone Miner Res 2019 Jan 28. Epub 2019 Jan 28.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.

Mineral and bone disorders including osteoporosis are common in dialysis patients and contribute to increased morbimortality. However, whether denosumab and alendronate are effective and safe treatments in hemodialysis patients is not known. Thus, we conducted a prospective, three-center study of 48 hemodialysis patients who were diagnosed as having osteoporosis and had not received anti-osteoporotic agents previously. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbmr.3676DOI Listing
January 2019
1 Read

An observational cohort study to produce and evaluate an improved tool to screen older women with back pain for osteoporotic vertebral fractures (Vfrac): study protocol.

Arch Osteoporos 2019 Jan 25;14(1):11. Epub 2019 Jan 25.

Bristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol, UK.

The aim of this study is to produce an easy to use checklist for general practitioners to complete whenever a woman aged over 65 years with back pain seeks healthcare. This checklist will produce a binary output to determine if the patient should have a radiograph to diagnose vertebral fracture.

Purpose: People with osteoporotic vertebral fractures are important to be identified as they are at relatively high risk of further fractures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11657-019-0558-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347587PMC
January 2019
2 Reads

Intervals between bone mineral density testing with dual-energy X-ray absorptiometry scans in clinical practice.

Osteoporos Int 2019 Jan 24. Epub 2019 Jan 24.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA.

Intervals between dual-energy X-ray absorptiometry (DXA) scans were evaluated in a large cohort of typical clinical practice. Intensive DXA scanning (intervals < 23 months) decreased substantially, from 16.7% in 2006 to 6. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00198-019-04847-5DOI Listing
January 2019
1 Read

Effects of adiponectin on osteoclastogenesis from mouse bone marrow-derived monocytes.

Exp Ther Med 2019 Feb 7;17(2):1228-1233. Epub 2018 Dec 7.

Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

The aim of the present study was to investigate the effects of adiponectin on bone marrow-derived monocytes (BMMs) in the process of osteoclastogenesis. Primary BMMs derived from the mouse bone marrow were cultured, which were then treated with different concentrations of adiponectin and macrophage colony stimulating factor (M-CSF). Cell viability was determined by measuring the absorbance after 24 h with Cell Counting Kit-8 reagent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2018.7069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327630PMC
February 2019
1 Read

[Prevention and treatment for vascular calcification in patients with diabetes mellitus.]

Clin Calcium 2019 ;29(2):225-230

Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.

It has been known that diabetes mellitus is known to have a high risk of cardiovascular diseases as well as osteoporosis. Prevention and treatment of vascular calcification in patients with diabeties mellitus by anti-osteoporosis agents is prospected bcause similar molecular mechanisms in bone tissue were found in calcified lesion in blood vessels. However, the anti-vascular calcification effect has not always been observed in clinical practice in contrast to basic research and animal experiments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.20837/4201902225DOI Listing
January 2019
4 Reads

Screw fixation of ACPHT acetabular fractures offers sufficient biomechanical stability when compared to standard buttress plate fixation.

BMC Musculoskelet Disord 2019 Jan 24;20(1):39. Epub 2019 Jan 24.

Department of Trauma, University Hospital Zurich, Zurich, Switzerland.

Background: Geriatric acetabular fractures require fixation with sufficient primary stability to allow for immediate full-weight bearing. Minimally-invasive procedures would be desirable in order to keep perioperative morbidity low. The purpose of this study was to compare the biomechanical strength of lag screw-only fixation of anterior column posterior hemi-transverse (ACPHT) acetabular fractures to standard anatomical plate fixation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12891-019-2422-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346571PMC
January 2019
1 Read

Three week versus six week immobilisation for stable Weber B type ankle fractures: randomised, multicentre, non-inferiority clinical trial.

BMJ 2019 Jan 23;364:k5432. Epub 2019 Jan 23.

Department of Surgery, Division of Orthopaedic and Trauma Surgery, Oulu University Hospital, Kajaanintie 50, PO Box 21, FI 90029 OYS, Oulu, Finland.

Objective: To determine whether treatment of isolated stable Weber B type ankle fractures with a cast or a simple orthotic device for three weeks produces non-inferior outcomes compared with conventional immobilisation in a cast for six weeks.

Design: Randomised, pragmatic, non-inferiority, clinical trial with blinded outcome assessment.

Setting: Two major trauma centres in Finland, 22 December 2012 to 6 June 2016. Read More

View Article

Download full-text PDF

Source
http://www.bmj.com/lookup/doi/10.1136/bmj.k5432
Publisher Site
http://dx.doi.org/10.1136/bmj.k5432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342249PMC
January 2019
5 Reads

Systemic comorbidities are associated with medication-related osteonecrosis of the jaws: case-control study.

Oral Dis 2019 Jan 23. Epub 2019 Jan 23.

Menzies Health Institute Queensland, Griffith University, Southport, Queensland, 4222, Australia.

Objectives: Medication-related osteonecrosis of the jaws (MRONJ) is a serious condition developed in up to 15% of patients who take antiresorptive medications. Its underlying pathogenesis remains unclear. The association between systemic comorbidities and MRONJ was investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/odi.13046DOI Listing
January 2019
1 Read

Healing of osteoporotic bone defects by micro-/nano-structured calcium phosphate bioceramics.

Nanoscale 2019 Feb;11(6):2721-2732

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China.

It is a particularly critical challenge to achieve enough bone regeneration in osteoporotic fractures with bone defects. In the present study, we designed a micro-/nano-structured calcium phosphate bioceramic composed of a nanoparticle-reinforced micro-whisker backbone (nwCaP). This sandwich-structured bioceramic exhibited a higher compressive strength, a suitable degradation rate and better cell attachment than traditional or intermediate bioceramics. Read More

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=C8NR09417A
Publisher Site
http://dx.doi.org/10.1039/c8nr09417aDOI Listing
February 2019
6 Reads

Untargeted Metabolomics Reveals the Protective Effect of Fufang Zhenshu Tiaozhi (FTZ) on Aging-Induced Osteoporosis in Mice.

Front Pharmacol 2018 8;9:1483. Epub 2019 Jan 8.

Key Unit of Modulating Liver to Treat Hyperlipemia SATCM (State Administration of Traditional Chinese Medicine), Guangdong Pharmaceutical University, Guangzhou, China.

Fufang Zhenzhu Tiaozhi (FTZ), as an effective traditional Chinese medicine, has been prescribed for more than 20 years. It has proven clinical efficacy as a prescription for patients with dyslipidemia, glucocorticoid- and high-fat-induced osteoporosis, but its effect on osteoporosis induced by aging is still unclear. The aim of this study was to investigate the anti-osteoporosis effect of FTZ in aging mice and revealed its biochemical action mechanism using metabolomics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2018.01483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331458PMC
January 2019
3 Reads

Transarticular tibiotalocalcaneal nailing versus open reduction and internal fixation for treatment of the elderly ankle fracture: protocol for a multicentre, prospective, randomised controlled trial.

BMJ Open 2019 Jan 21;9(1):e026360. Epub 2019 Jan 21.

Department of Orthopaedics, The Prince Charles Hospital, Chermside, Queensland, Australia.

Introduction: Ankle fractures are common in the elderly population. Surgical fixation is technically challenging and often results in complications due to high rates of osteoporosis and vascular disease. Open reduction and internal fixation (ORIF) often requires prolonged periods of non-weight bearing increasing the risks of complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-026360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347874PMC
January 2019
2 Reads

Catalpol promotes the osteogenic differentiation of bone marrow mesenchymal stem cells via the Wnt/β-catenin pathway.

Stem Cell Res Ther 2019 Jan 22;10(1):37. Epub 2019 Jan 22.

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Rd 600, Shanghai, 200233, People's Republic of China.

Background: Rehmanniae Radix is a traditional herbal medicine in East Asia that has been widely used to treat patients with osteoporosis. However, the effect of catalpol, the primary active principle component of Rehmanniae Radix, on the function of bone marrow mesenchymal stem cells (BMSCs) and the underlying molecular mechanisms associated with its activity remain poorly understood.

Methods: The effect of catalpol on the proliferation of BMSCs was evaluated using a Cell Counting Kit-8 assay. Read More

View Article

Download full-text PDF

Source
https://stemcellres.biomedcentral.com/articles/10.1186/s1328
Publisher Site
http://dx.doi.org/10.1186/s13287-019-1143-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341609PMC
January 2019
3 Reads

Poor outcomes for osteoporotic patients undergoing conversion total hip arthroplasty following prior failed dynamic hip screw fixation: a nationwide retrospective cohort study.

J Int Med Res 2019 Jan 23:300060518823410. Epub 2019 Jan 23.

1 Department of Anesthesiology, Wuhan Fourth Hospital; Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Qiaokou District, Wuhan, China.

Objectives: This study was performed to compare the long-term clinical and radiological outcomes of conversion total hip arthroplasty (CTHA) following prior failed InterTan nail (IT) fixation or dynamic hip screw (DHS) fixation in Asian patients with osteoporotic intertrochanteric hip fractures (IHFs) and to clarify which implant tends to be more favourable for CTHA.

Methods: Records of consecutive Asian patients with osteoporosis who underwent conversion of failed primary unilateral IT or DHS fixation to THA from 2010 to 2013 were extracted from the comprehensive database of the China Pacific Insurance Company Ltd. All consecutive procedures were managed by high-volume surgeons. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300060518823410DOI Listing
January 2019
2 Reads

Combined administration on You-Gui Yin and low-dose Raloxifene partially attenuates the bone loss in ovariectomized mice through the proliferation and osteogenic differentiation of bone marrow stromal cells.

Phytomedicine 2018 Sep 5;53:286-293. Epub 2018 Sep 5.

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Room 109, Chemistry Building, 151 Malianwa North Road, Haidian District, Beijing 100193, China. Electronic address:

Background: Osteoporosis is a systemic skeletal disease of fragility fractures due to the loss of mass and deterioration of the microarchitecture of bone.

Purpose: The aim of the study was to assess the osteogenic effects and the underlying mechanisms of the combined administration of You-Gui Yin (YGY) and Raloxifene hydrochloride (RLX) in ovariectomized (OVX) mice.

Methods: First, a classic animal model was used to mimic postmenopausal osteoporosis through the removal of the ovary of mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phymed.2018.09.014DOI Listing
September 2018
3 Reads

Prevalence of hypovitaminosis D in India & way forward.

Indian J Med Res 2018 Nov;148(5):548-556

Centre for Promotion of Nutrition Research and Training with Special Focus on North East, Tribal & Inaccessible Population, Division of Nutrition, Indian Council of Medical Research (Campus II), Tuberculosis Association of India Building, New Delhi; ICMR-Desert Medicine Research Centre, Jodhpur, India.

Deficiency of vitamin D or hypovitaminosis D is widespread irrespective of age, gender, race and geography and has emerged as an important area of research. Vitamin D deficiency may lead to osteoporosis (osteomalacia in adults and rickets in children) along with calcium deficiency. Its deficiency is linked with low bone mass, weakness of muscles and increased risk of fracture. Read More

View Article

Download full-text PDF

Source
http://www.ijmr.org.in/text.asp?2018/148/5/548/249984
Publisher Site
http://dx.doi.org/10.4103/ijmr.IJMR_1807_18DOI Listing
November 2018
3 Reads

Treating osteoporosis to prevent fractures: current concepts and future developments.

J Intern Med 2019 Jan 18. Epub 2019 Jan 18.

Geriatric Medicine, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.

Antiresorptive drugs, such as the bisphosphonates and the RANKL inhibitor denosumab, are currently the most widely used osteoporosis medications. These drugs increase bone mineral density (BMD) and reduce the risk of vertebral (by 40-70%), nonvertebral (by 25-40%) and hip fractures (by 40-53%) in postmenopausal women with osteoporosis. Due to the risk of rare side-effects, the use of bisphosphonates has been limited to up to 10 years with oral bisphosphonates and 6 years with intravenous zoledronic acid. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/joim.12873DOI Listing
January 2019
3 Reads

Tai chi for treating osteopenia and primary osteoporosis: a meta-analysis and trial sequential analysis.

Clin Interv Aging 2019 3;14:91-104. Epub 2019 Jan 3.

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China,

Purpose: The aim of this meta-analysis was to evaluate the efficacy of Tai chi (TC) as an adjuvant treatment for osteopenia and primary osteoporosis.

Methods: We went through eight databases to identify relevant randomized controlled trials that compared TC with a control group. The primary outcome was osteoporosis-related fractures (fracture incidence). Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/tai-chi-for-treating-osteopenia-an
Publisher Site
http://dx.doi.org/10.2147/CIA.S187588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322510PMC
January 2019
4 Reads

Trabecular Bone Score (TBS) in Clinical Practice - Rewiev.

Ortop Traumatol Rehabil 2018 Oct;20(5):347-359

Zakład Chorób Kości i Stawów, Instytut Fizjoterapii, Uniwersytet Jagielloński - Collegium Medicum, Kraków, Polska / Department of Bone and Joint Diseases, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow.

Bone mineral density (BMD) assessment is the basic method for assessing fracture risk and diagnosing osteoporosis according to the World Health Organization (WHO). Osteoporosis is diagnosed when the T-score at the proximal femur or spine is T≤-2.5; however, 70% of fractures occur in patients who do not fulfil this criterion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5604/01.3001.0012.7281DOI Listing
October 2018
1 Read

Calcium supplementation from dairy products in the diet of women over the age of 55 from Zabrze (the Silesian Osteoactive Study - nutritional part).

Reumatologia 2018 23;56(6):382-387. Epub 2018 Dec 23.

Department of Orthopaedic Surgery, the Sports-Clinic, Żory, Poland.

Objectives: The primary goal of the study was to assess calcium intake among women over the age of 55.

Material And Methods: The study participants were randomly selected from the female population of Zabrze, a town in the Upper Silesia Region in Poland, making use of the framework of the Silesia Osteoactive Study Project. The Semi-Quantitative Food Frequency Questionnaire (sFFQ) was used for nutritional assessment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/reum.2018.80716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330677PMC
December 2018
2 Reads

Effect of a Fracture Liaison Service on the Rate of Subsequent Fracture Among Patients With a Fragility Fracture in the Norwegian Capture the Fracture Initiative (NoFRACT): A Trial Protocol.

JAMA Netw Open 2018 Dec 7;1(8):e185701. Epub 2018 Dec 7.

Department of Clinical Medicine, Arctic University of Norway, Tromsø, Norway.

Importance: Fragility fracture is a major health issue because of the accompanying morbidity, mortality, and financial cost. Despite the high cost to society and personal cost to affected individuals, secondary fracture prevention is suboptimal in Norway, mainly because most patients with osteoporotic fractures do not receive treatment with antiosteoporotic drugs after fracture repair.

Objectives: To improve secondary fracture prevention by introducing a standardized intervention program and to investigate the effect of the program on the rate of subsequent fractures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamanetworkopen.2018.5701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324344PMC
December 2018
7 Reads

Normocalcemic Hyperparathyroidism.

Authors:
Sabrina Corbetta

Front Horm Res 2019 19;51:23-39. Epub 2018 Nov 19.

Parathyroid hormone (PTH) disorders are characterized by a wide spectrum of clinical and biochemical presentations. The increasing use of serum PTH assay in the set of the diagnostic workout in patients with osteoporosis has identified patients with features of surgically confirmed primary hyperparathyroidism (PHPT) associated with persistent normal serum calcium levels, which has been recognized as a distinct entity from hypercalcemic PHPT (HPHPT) by the last international consensus. Normocalcemic PHPT (NPHPT) affects about 6-8% of PHPT patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000491036DOI Listing
November 2018
5 Reads

Th17 cell frequency is associated with low bone mass in primary sclerosing cholangitis.

J Hepatol 2019 Jan 11. Epub 2019 Jan 11.

Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany; Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany; University Medical Center Hamburg-Eppendorf, Germany. Electronic address:

Background And Aims: Osteoporotic fractures are a major cause of morbidity and reduced quality of life in patients with primary sclerosing cholangitis (PSC), a progressive bile duct disease of unknown origin. Although it is generally assumed that this pathology is a consequence of impaired calcium homeostasis and malabsorption, the cellular and molecular causes of PSC-associated osteoporosis are unknown.

Methods: We determined bone mineral density by dual-X-ray absorptiometry and assessed bone microstructure by high-resolution peripheral quantitative computed tomography in PSC patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2018.12.035DOI Listing
January 2019
1 Read

Management of acute knee dislocations: anatomic repair and ligament bracing as a new treatment option-results of a multicentre study.

Knee Surg Sports Traumatol Arthrosc 2019 Jan 11. Epub 2019 Jan 11.

Clinic of Trauma, Hand and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

Purpose: The literature shows no consensus regarding the best method and timing for the treatment of acute knee dislocations. Studies indicate that a one-stage procedure performed in the early stages of injury can lead to superior results. The aim of this study was to evaluate the results after performing early surgical repair with additional suture augmentation (ligament bracing) of all torn ligaments in acute knee dislocations. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00167-018-5317-4
Publisher Site
http://dx.doi.org/10.1007/s00167-018-5317-4DOI Listing
January 2019
5 Reads

Common mechanisms and holistic care in atherosclerosis and osteoporosis.

Arthritis Res Ther 2019 Jan 10;21(1):15. Epub 2019 Jan 10.

Amsterdam Rheumatology and Immunology Centre, Location VU University Medical Centre, Amsterdam 1007 MB, Amsterdam, 1104 LP, The Netherlands.

Cardiovascular (CV) disease and osteoporosis (OP) have become increasing challenges in the aging population and even more in patients with inflammatory rheumatic diseases, such as rheumatoid arthritis, spondyloarthropathies, and systemic lupus erythematosus. In this review, we discuss how the epidemiology and pathogenesis of CV events and OP are overlapping. Smoking, diabetes mellitus, physical inactivity as conventional risk factors as well as systemic inflammation are among the modifiable risk factors for both CV events and bone loss. Read More

View Article

Download full-text PDF

Source
https://arthritis-research.biomedcentral.com/articles/10.118
Publisher Site
http://dx.doi.org/10.1186/s13075-018-1805-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329187PMC
January 2019
5 Reads

Antipsychotic use and fracture risk: An evaluation of incidence at a Veterans Affairs medical center.

Ment Health Clin 2019 Jan 4;9(1):6-11. Epub 2019 Jan 4.

Introduction: Recent meta-analyses have found a correlation between schizophrenia and increased fracture risk with one contributing factor potentially being antipsychotic-induced hyperprolactinemia, which may accelerate bone turnover. The objective of this study is to evaluate fracture rates in patients on long-term antipsychotic therapy to see if screening for osteoporosis should be included with routine monitoring.

Methods: Patients exposed to antipsychotics for ≥3 months during a 10-year study period were included in this retrospective analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.9740/mhc.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322822PMC
January 2019
2 Reads

Outcomes for Elderly Patients With Atypical Femoral Fractures Compared to Typical Femoral Fractures for Length of Stay, Discharge Destination, and 30-Day Mortality Rate.

Geriatr Orthop Surg Rehabil 2018 26;9:2151459318820222. Epub 2018 Dec 26.

Department of Trauma and Orthopaedics, King's College Hospital NHS Foundation Trust, Princess Royal University Hospital, London, United Kingdom.

Introduction: Despite increasing recognition of atypical femoral fractures (AFFs), there's conflicting evidence about incidence, aetiology, and short-term outcomes of these injuries. This study reports the incidence of AFFs at our center and compares the early postoperative outcomes against typical femoral fractures (TFFs).

Methods: A retrospective observational cohort study of patients presenting to our trauma unit between November 2015 and July 2016 was undertaken. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2151459318820222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311535PMC
December 2018
2 Reads

SPA0355 prevents ovariectomy-induced bone loss in mice.

Korean J Physiol Pharmacol 2019 Jan 26;23(1):47-54. Epub 2018 Dec 26.

Department of Biochemistry, Chonbuk National University Medical School, Jeonju 54896, Korea.

Estrogen withdrawal in post-menopausal women leads to overactivation of osteoclasts, which contributes to the development of osteoporosis. Inflammatory cytokines are known as one of mechanisms of osteoclast activation after estrogen deficiency. SPA0355 is a thiourea derivative that has been investigated for its antioxidant and anti-inflammatory activities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4196/kjpp.2019.23.1.47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315098PMC
January 2019
1 Read

Assessment and hormonal management of osteoporosis.

Authors:
F Trémollieres

Climacteric 2019 Jan 9:1-5. Epub 2019 Jan 9.

a Menopause Center, Hôpital Paule de Viguier , University Hospital of Toulouse , Toulouse , France.

Postmenopausal osteoporosis is a frequent health issue in women. Because osteoporosis-related fractures cause a significant increase in mortality and morbidity, it is clinically important to identify as soon as possible women at increased risk for future fracture so that preventive measures can be instituted. At the beginning of menopause, evaluation of the subsequent risk of fracture is not so easy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13697137.2018.1555582DOI Listing
January 2019
3 Reads

Effect of treatment on back pain and back extensor strength with a spinal orthosis in older women with osteoporosis: a randomized controlled trial.

Arch Osteoporos 2019 Jan 9;14(1). Epub 2019 Jan 9.

Division of Family Medicine and Primary Care, department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.

The treatment effect of an activating spinal orthosis on back pain and back extensor strength was compared to a training group and to a control group. Between the groups, there was no significant difference in back pain, back extensor strength, or kyphosis index after the 6 months of treatment.

Purpose: The aim of this study was to study the effect of treatment with an activating spinal orthosis on back pain, back extensor strength, and kyphotic index. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11657-018-0555-0
Publisher Site
http://dx.doi.org/10.1007/s11657-018-0555-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325994PMC
January 2019
1 Read