9,049 results match your criteria Osteoporosis Primary

Prevention and Treatment of Glucocorticoid-Induced Osteoporosis in Adults: Consensus Recommendations From the Belgian Bone Club.

Front Endocrinol (Lausanne) 2022 9;13:908727. Epub 2022 Jun 9.

Centre for Metabolic Bone Diseases, Department of Geriatrics, University Hospitals Leuven, Leuven, Belgium.

Glucocorticoids are effective immunomodulatory drugs used for many inflammatory disorders as well as in transplant recipients. However, both iatrogenic and endogenous glucocorticoid excess are also associated with several side effects including an increased risk of osteoporosis and fractures. Glucocorticoid-induced osteoporosis (GIOP) is a common secondary cause of osteoporosis in adults. Read More

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Recent fall and high imminent risk of fracture in older men and women.

Age Ageing 2022 Jun;51(6)

San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA.

Background: despite fall history being a well-known risk factor for falls and fractures, the association between very recent falls and imminent fracture risk is not clearly elucidated.

Objective: to study the very recent (<4 months) fall-related absolute risk of fractures in the following year.

Methods: two large prospective cohort studies of women (Study of Osteoporotic Fractures [SOF]) and men (Osteoporotic Fractures in Men Study [MrOS]) aged 65 years or older were included. Read More

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Identification of a novel splicing mutation and genotype-phenotype correlations in rare PLS3-related childhood-onset osteoporosis.

Orphanet J Rare Dis 2022 Jun 25;17(1):247. Epub 2022 Jun 25.

Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

Background: X-linked early-onset osteoporosis, caused by mutations in plastin3 (PLS3), is an extremely rare disease characterized by low bone mineral density (BMD) and recurrent osteoporotic fractures. There is limited information on genetic and phenotypic spectrum, as well as genotype-phenotype correlations of the disease. Moreover, whether decreased PLS3 levels were also involved in osteoporosis among subjects without PLS3 pathogenic mutations remains unknown. Read More

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Prescribing Alzheimer's Disease treatments by provider type and geographic region: a comparison among physicians, nurse practitioners, and physician assistants.

BMC Geriatr 2022 Jun 25;22(1):522. Epub 2022 Jun 25.

Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, WA, USA.

Background: The estimated increase in Alzheimer's Disease (AD) caseload may present a logistical challenge to the US healthcare system. While nurse practitioners (NPs) and physician assistants (PAs) are increasingly delivering primary care to patients with chronic diseases, the nature of their prescribing of AD medications is largely unknown. The primary objective of this study was to compare the prescribing of AD medications across provider types (physician, NP, and PA) and geographic regions. Read More

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Artificial intelligence-based radiomics on computed tomography of lumbar spine in subjects with fragility vertebral fractures.

J Endocrinol Invest 2022 Jun 25. Epub 2022 Jun 25.

Department of Biomedical Sciences, Humanitas University, Via R. Levi Montalcini 4, Pieve Emanuele, 20090, Milan, Italy.

Purpose: There is emerging evidence that radiomics analyses can improve detection of skeletal fragility. In this cross-sectional study, we evaluated radiomics features (RFs) on computed tomography (CT) images of the lumbar spine in subjects with or without fragility vertebral fractures (VFs).

Methods: Two-hundred-forty consecutive individuals (mean age 60. Read More

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Cardiovascular Safety and Effectiveness of Bisphosphonates: From Intervention Trials to Real-Life Data.

Nutrients 2022 Jun 7;14(12). Epub 2022 Jun 7.

Bone Metabolic Diseases Unit, Department of Experimental, Clinical and Biomedical Sciences, University of Florence, 50139 Florence, Italy.

Both osteoporosis with related fragility fractures and cardiovascular diseases are rapidly outspreading worldwide. Since they are often coexistent in elderly patients and may be related to possible common pathogenetic mechanisms, the possible reciprocal effects of drugs employed to treat these diseases have to be considered in clinical practice. Bisphosphonates, the agents most largely employed to decrease bone fragility, have been shown to be overall safe with respect to cardiovascular diseases and even capable of reducing cardiovascular morbidity in some settings, as mainly shown by real life studies. Read More

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Acta Clin Croat 2021 Dec;60(4):617-626

1Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 2University of Applied Health Sciences, Zagreb, Croatia; 3Department of Radiology and Nuclear Medicine, PET/CT Center, Medikol Polyclinic, Zagreb, Croatia; 4Department of Nuclear Medicine and Radiology, Martini Hospital, Groningen, The Netherlands; 5Department of Surgery, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 6School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

The bone health guidelines for breast cancer (BC) patients recommend bone mineral density (BMD) testing. Patients with low BMD and elevated serum calcium levels (SCLs) are further evaluated for primary hyperparathyroidism (PHPT). We aimed to determine the prevalence of PHPT in treated BC patients with low BMD and analyze the association of SCLs with histopathologic tumor features and cancer treatment. Read More

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December 2021

LncRNA RAD51-AS1 Regulates Human Bone Marrow Mesenchymal Stem Cells via Interaction with YBX1 to Ameliorate Osteoporosis.

Stem Cell Rev Rep 2022 Jun 21. Epub 2022 Jun 21.

Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.

Long noncoding RNA (lncRNA) is a new key regulatory molecule in the occurrence of osteoporosis, but its research is still in the primary stage. In order to study the role and mechanism of lncRNA in the occurrence of osteoporosis, we reannotated the GSE35956 datasets, compared and analyzed the differential expression profiles of lncRNAs between bone marrow mesenchymal stem cells (hBMSCs) from healthy and osteoporotic patients, and then screened a lncRNA RAD51-AS1 with low expression in hBMSCs from osteoporotic patients, and its role in the occurrence of osteoporosis has not been studied. We confirmed that the expression level of lncRNA RAD51-AS1 in hBMSCs from patients with osteoporosis was significantly lower than those from healthy donors. Read More

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Refined Treatment Response Criteria for Indolent Systemic Mastocytosis proposed by the ECNM-AIM Consortium.

J Allergy Clin Immunol Pract 2022 Jun 17. Epub 2022 Jun 17.

Division of Allergy and Clinical Immunology, University of Salerno, Italy.

Indolent systemic mastocytosis (ISM) has a favorable prognosis and normal life expectancy. However, many patients suffer from mast cell (MC) mediator-related symptoms, which significantly affect quality of life (QoL). Cutaneous, gastrointestinal and neurological complaints, musculoskeletal pain as well as the presence of skin lesions, anaphylaxis and osteoporosis are the main symptoms and signs in ISM and must be assessed in all patients before and during treatment. Read More

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Drug Investigation to Dampen the Comorbidity of Rheumatoid Arthritis and Osteoporosis via Molecular Docking Test.

Curr Issues Mol Biol 2022 Feb 23;44(3):1046-1061. Epub 2022 Feb 23.

Department of Bio-Health Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Korea.

At present, most rheumatoid arthritis (RA) patients are at risk of osteoporosis (OP), which is increased by 1.5 times compared to non-RA individuals. Hence, we investigated overlapping targets related directly to the occurrence and development of RA and OP through public databases (DisGeNET, and OMIM) and literature. Read More

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February 2022

The Imbalance of Cytokines and Lower Levels of Tregs in Elderly Male Primary Osteoporosis.

Front Endocrinol (Lausanne) 2022 31;13:779264. Epub 2022 May 31.

Departments of Endocrinology, Qujing Affiliated Hospital of Kunming Medical University, Yunnan, China.

Introduction: Osteoporosis (OP) is a debilitating disease that brings a heavy burden to individuals and society with reduced quality of life and lifespan. However, it's frequently overlooked and poorly studied in elderly male patients. Worse still, few anti-osteoporosis drugs are effective at the prevention and treatment of osteoporosis in men. Read More

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Target Values and Daytime Variation of Bone Turnover Markers in Monitoring Osteoporosis Treatment After Fractures.

JBMR Plus 2022 Jun 9;6(6):e10633. Epub 2022 May 9.

Department of Endocrinology, Morbid Obesity and Preventive Medicine Oslo University Hospital Oslo Norway.

The serum bone turnover markers (BTM) procollagen type 1 N-terminal propeptide (P1NP) and C-terminal cross-linking telopeptide of type 1 collagen (CTX) are recommended for monitoring adherence and response of antiresorptive drugs (ARD). BTM are elevated about 1 year after fracture and therefore BTM target values are most convenient in ARD treatment follow-up of fracture patients. In this prospective cohort study, we explored the cut-off values of P1NP and CTX showing the best discriminating ability with respect to adherence and treatment effects, reflected in bone mineral density (BMD) changes. Read More

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Decreasing Rates of Fracture-Related Hospitalization With Primary Biliary Cholangitis: Insights From the Nationwide Inpatient Sample.

Cureus 2022 May 14;14(5):e25001. Epub 2022 May 14.

Internal Medicine/Gastroenterology, Valleywise Health Medical Center, Phoenix, USA.

Introduction Primary biliary cholangitis (PBC) is associated with an increased risk of developing fractures. Current guidelines recommend measures that can help prevent the development of fractures in these patients. The purpose of this study was to trend the rates of hospitalizations related to fractures and their burden on healthcare. Read More

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Effect of Denosumab on the Change of Osteoclast Precursors Compared to Zoledronate Treatment in Postmenopausal Women with Osteoporosis.

J Bone Metab 2022 May 31;29(2):93-101. Epub 2022 May 31.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Background: A rapid increase in bone turnover and bone loss has been observed in response to the discontinuation of denosumab. It led to an acute increase in the fracture risk, similar to that observed in the untreated patients. We aimed to investigate the effect of denosumab on osteoclast (OC) precursor cells compared to that of zoledronate. Read More

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Relationship between Coffee Consumption and Osteoporosis Risk Determined by the ESR1 Polymorphism rs2982573.

J Nutr Health Aging 2022 ;26(6):558-563

Yung-Po Liaw, No. 110 Sec. 1 Jianguo N. Road, Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City- 40201, Taiwan; Tel: +886436097722 ext. 11838; fax: +886423248179, Email:

Background: The development of osteoporosis is partly explained by interactions between genetic and lifestyle or environmental factors.

Objectives: In the current study, we determined the relationship between coffee consumption and the risk of osteoporosis among individuals with ESR1 rs2982573 in Taiwan.

Design, Participants And Setting: In this population-based cross-sectional study, we used genetic, demographic, and lifestyle data from participants recruited in Taiwan Biobank (TWB) between 2016 and 2019. Read More

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Risks of serious adverse events and kidney injury in patients treated with ibandronate: A systematic review and meta-analysis.

Pharmacotherapy 2022 Jun 18. Epub 2022 Jun 18.

Department of Pharmacy, Okayama Saiseikai General Hospital, Japan.

Background: Several reports suggest that adverse events caused by ibandronate are less serious than those associated with the other bisphosphonates. The purpose of this systematic review and meta-analysis was to determine whether ibandronate has low rates of serious adverse events and kidney injury.

Methods: Randomized controlled trials were selected, and the study populations consisted of adult patients with osteoporosis. Read More

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Management of Breast Cancer Survivors by Gynecologists.

Clin Obstet Gynecol 2022 Jun 16. Epub 2022 Jun 16.

Department of Obstetrics and Gynecology, Holden Clinical Cancer Center, University of Iowa, Iowa City, Iowa.

Breast cancer patients commonly present to their OBGYN during the process of diagnosis and treatment of breast cancer both for specific gynecologic needs and for primary care follow up. These patients require counseling on contraception, hormone use, and fertility at diagnosis. During treatment and survivorship, patients will face a variety of side effects from treatments leading to vasomotor symptoms, vulvovaginal discomfort, sexual dysfunction, osteoporosis, and vaginal bleeding. Read More

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Bone Morphogenetic Protein in Anterior Lumbar Interbody Fusions: A Propensity-Matched Medicare Outcome Analysis.

Int J Spine Surg 2022 Jun 14. Epub 2022 Jun 14.

Department of Neurosurgery, University of Illinois at Chicago, Chicago, IL, USA.

Background: Bone morphogenetic protein (BMP) is a costly agent commonly used in spine surgery. Its effectiveness and complication profile have never been studied in a large, propensity-matched population following its approval by the Food and Drug Administration for use in single-level anterior lumbar interbody fusion (ALIF) surgeries.

Objective: To investigate the rate of symptomatic pseudarthrosis or need for revision surgery after single-level stand-alone ALIFs with and without the use of BMP. Read More

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Effect of a home-based resistance exercise program in elderly participants with osteoporosis: a randomized controlled trial.

Osteoporos Int 2022 Jun 15. Epub 2022 Jun 15.

Department of Nursing, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

The effectiveness of home-based resistance exercise in elder participants with osteoporosis remains unclear. This study demonstrates the beneficial effects of this mode of exercise on improving physical function, increasing confidence in exercise, and reducing fear of falling.

Introduction: This study aims to evaluate the effect of a home-based resistance exercise (HBRE) program versus control on physical function, exercise self-efficacy, falling efficacy, and health-related quality of life (HRQOL). Read More

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Serum biomarker-based osteoporosis risk prediction and the systemic effects of Trifolium pratense ethanolic extract in a postmenopausal model.

Chin Med 2022 Jun 14;17(1):70. Epub 2022 Jun 14.

College of Veterinary Medicine and Cardiovascular Research Institute, Kyungpook National University, 80 Daehak-ro, Daegu, 41566, Republic of Korea.

Background: Recent years, a soaring number of marketed Trifolium pratense (red clover) extract products have denoted that a rising number of consumers are turning to natural alternatives to manage postmenopausal symptoms. T. pratense ethanolic extract (TPEE) showed immense potential for their uses in the treatment of menopause complications including osteoporosis and hormone dependent diseases. Read More

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Anti-osteoporotic Drug Utilization Rates for Secondary Prevention Among Patients with Osteoporotic Fractures.

Rambam Maimonides Med J 2022 Jun 12. Epub 2022 Jun 12.

Department of Family Medicine, University of Health Sciences, Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.

Objectives: Anti-osteoporotic drugs (AOD) are essential for secondary prevention of osteoporotic fracture (OF) in patients with established osteoporosis. However, data about AOD utilization rates are scarce among patients with OF. This study was therefore aimed at determining the AOD utilization rates among those particularly vulnerable patients. Read More

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Does motor control training improve pain and function in adults with symptomatic lumbar disc herniation? A systematic review and meta-analysis of 861 subjects in 16 trials.

Br J Sports Med 2022 Jun 14. Epub 2022 Jun 14.

Faculty of Science, Department of Health Sciences, Vrije Universiteit, Amsterdam, The Netherlands.

Objective: To evaluate the effectiveness of motor control training (MCT) compared with other physical therapist-led interventions, minimal/no intervention or surgery in patients with symptomatic lumbar disc herniation (LDH).

Design: Systematic review and meta-analysis.

Data Sources: Eight databases and the ClinicalTrials. Read More

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Incidental Identification of Vertebral Fragility Fractures by Chest CT in COVID-19-Infected Individuals.

Cureus 2022 May 9;14(5):e24867. Epub 2022 May 9.

Orthopaedics, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Pune, IND.

Introduction It is critical to identify asymptomatic vertebral compression fractures (VCFs) as soon as possible in order to avoid subsequent fragility fractures. The purpose of the study was to see how many vertebral compression fractures there were in patients admitted to the COVID-19 pneumonia unit in a single tertiary care hospital who underwent chest computed tomography (CT) scans. Materials and methods Sagittal reconstruction of the thoracic spine was done in around 504 patients and classified into mild, moderate, and severe categories, and we compared it with the radiological reports of the same. Read More

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The impact of bone mineral density screening on incident fractures and healthcare resource utilization among postmenopausal breast cancer survivors treated with aromatase inhibitors.

Osteoporos Int 2022 Jun 14. Epub 2022 Jun 14.

Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Bone mineral density screening prior to initiating aromatase inhibitor therapy was associated with lower incident bone fractures and healthcare resource utilization among postmenopausal breast cancer survivors.

Introduction: Postmenopausal women with hormone receptor-positive breast cancer (BC) often receive aromatase inhibitor (AI) therapy. However, AIs induce bone loss and BC survivors are at an increased risk of bone fractures. Read More

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Osteoporosis in 2022: Care gaps to screening and personalised medicine.

Best Pract Res Clin Rheumatol 2022 Jun 9:101754. Epub 2022 Jun 9.

MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton General Hospital, Southampton, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospitals Southampton NHS Foundation Trust, Southampton, UK. Electronic address:

Osteoporosis care has evolved markedly over the last 50 years, such that there are now an established clinical definition, validated methods of fracture risk assessment, and a range of effective pharmacological agents. However, it is apparent that both in the context of primary and secondary fracture prevention, there is a considerable gap between the population at high fracture risk and those actually receiving appropriate antiosteoporosis treatment. In this narrative review article, we document recent work describing the burden of disease, approaches to management, and service provision across Europe, emerging data on gaps in care, and existing/new ways in which these gaps may be addressed at the level of healthcare systems and policy. Read More

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Development and external validation of a 1- and 5-year fracture prediction tool based on electronic medical records data: The EPIC risk algorithm.

Bone 2022 Jun 9;162:116469. Epub 2022 Jun 9.

IDIAP Jordi Gol Primary Care Research Institute; Ambit Barcelona, Primary Care Department, Institut Catala de la Salut; GREMPAL Research Group; CIBER of Healthy Ageing and Frailty Research (CIBERFes), Instituto de Salud Carlos III.

Objectives: We aimed to develop and validate a fracture risk algorithm for the automatic identification of subjects at high risk of imminent and long-term fracture risk.

Research, Design, And Methods: A cohort of subjects aged 50-85, between 2007 and 2017, was extracted from the Catalan information system for the development of research in primary care database (SIDIAP). Participants were followed until the earliest of death, transfer out, fracture, or 12/31/2017. Read More

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Clinical Challenges in Diagnosis, Tumor Localization and Treatment of Tumor-Induced Osteomalacia: Outcome of a Retrospective Surveillance.

J Bone Miner Res 2022 Jun 11. Epub 2022 Jun 11.

Division of Nephrology and Endocrinology, The University of Tokyo Hospital, Tokyo, Japan.

Context: Tumor-induced osteomalacia (TIO) is an acquired fibroblast growth factor 23 (FGF23)-related hypophosphatemic osteomalacia caused by phosphaturic mesenchymal tumors (PMTs) developed in the bone or soft tissue. Diagnostic delay should be addressed, and ideal techniques to localize PMTs and efficient treatment options should be explored to improve the outcomes of this rare disease.

Objective: To clarify the detailed clinical course and outcomes of TIO patients. Read More

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Supporting patients to get the best from their osteoporosis treatment: a rapid realist review of what works, for whom, and in what circumstance.

Osteoporos Int 2022 Jun 11. Epub 2022 Jun 11.

Clinical Pharmacy, Aston University, Birmingham, UK.

Systematic reviews that examine effectiveness of interventions to improve medicines optimisation do not explain how or why they work. This realist review identified that interventions which effectively optimise medicines use in osteoporosis include opportunities to address patients' perceptions of illness and treatment and/or support primary care clinician decision making.

Introduction: In people with osteoporosis, adherence to medicines is poorer than other diseases and patients report follow-up is lacking, and multiple unmet information needs. Read More

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Pharmacological inhibition of DKK1 promotes spine fusion in an ovariectomized rat model.

Bone 2022 Jun 8;162:116456. Epub 2022 Jun 8.

Department of Pathology, Johns Hopkins University, Baltimore, MD 21205,USA. Electronic address:

Osteoporosis is common in patients undergoing spine surgery, and carries a considerable risk of adverse outcomes. New methods to positively influence bone regeneration and spine fusion under osteoporotic conditions would be impactful. Neutralizing anti-Dickkopf-1 (DKK1) antibodies has been used as a bone anabolic agent, and recently reported by our group to aid in stem cell-mediated appendicular bone regeneration. Read More

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Non-diabetic ketoacidosis secondary to primary hyperthyroidism: A case report.

Medicine (Baltimore) 2022 Jun 10;101(23):e28253. Epub 2022 Jun 10.

Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar.

Introduction: There are variable complications of hyperthyroidism, including atrial fibrillation, heart failure, osteoporosis, and thyroid storm. One infrequent complication of hyperthyroidism is non-diabetic ketoacidosis (NDKA). To the best of our knowledge, our case is the third report of NDKA related to thyrotoxicosis. Read More

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