7,249 results match your criteria Osteoporosis Primary


Management of fracture risk in Parkinson's: A revised algorithm and focused review of treatments.

Parkinsonism Relat Disord 2019 Apr 8. Epub 2019 Apr 8.

Older People's Unit, Royal United Hospitals Bath NHS Foundation Trust, Combe Park, Bath, BA1 3NG, UK; Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol, BS10 5NB, UK.

Introduction: Falls and fractures are a cause of substantial morbidity in Parkinson's. Despite an excess risk of both falls and osteoporosis, people with Parkinson's perceive that they are less likely to fracture than their peers, despite actually being at higher fracture risk. Recognising this increased risk, in 2014 we published an algorithm to guide management of fracture risk in this high-risk population. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.03.021DOI Listing
April 2019
1 Read

Author Correction: An atlas of genetic influences on osteoporosis in humans and mice.

Nat Genet 2019 Apr 15. Epub 2019 Apr 15.

Department of Human Genetics, McGill University, Montréal, Québec, Canada.

In the version of this article initially published, in Fig. 5a, the data in the right column of 'DAAM2 gRNA1' were incorrectly plotted as circles indicating 'untreated' rather than as squares indicating 'treated'. The error has been corrected in the HTML and PDF versions of the article. Read More

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http://www.nature.com/articles/s41588-019-0415-x
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http://dx.doi.org/10.1038/s41588-019-0415-xDOI Listing
April 2019
1 Read

Acupuncture for primary osteoporosis: A network meta-analysis of randomized controlled trials protocol.

Medicine (Baltimore) 2019 Apr;98(15):e15108

Clinical Medical College of Acupuncture, Moxibustion and Rehabilitation.

Background: A large number of randomized controlled trials (RCTs) have shown that acupuncture (ACU) has certain advantages over pharmacotherapies in the treatment of primary osteoporosis (POP). However, due to the diversity of ACU treatments, its relative effectiveness have not yet been studied and explained. Therefore, based on the network meta-analysis (NMA), this study will compare the differences in the efficacy of multiacupuncture in the treatment of POP, to provide a reference for clinical treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000015108DOI Listing
April 2019
1 Read

State of the art in osteoporosis risk assessment and treatment.

J Endocrinol Invest 2019 Apr 12. Epub 2019 Apr 12.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.

Background: Osteoporosis constitutes a major public health problem, through its association with age-related fractures, particularly of the hip, vertebrae, distal forearm, and humerus. Over recent decades, it has evolved from being viewed as an inevitable consequence of ageing, to being recognised as a serious and eminently treatable disease.

Materials And Methods: In this article, we review the literature pertaining to the epidemiology of osteoporosis, associated health burden, approaches to risk assessment and treatment. Read More

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http://link.springer.com/10.1007/s40618-019-01041-6
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http://dx.doi.org/10.1007/s40618-019-01041-6DOI Listing
April 2019
2 Reads

Biological secondary contributors to osteoporosis in fractured patients, is an early systematic assay relevant?

Joint Bone Spine 2019 Apr 9. Epub 2019 Apr 9.

Rheumatology Department, Cochin Hospital, 75014 Paris, France; INSERM U1153, 75014 Paris France. Electronic address:

Objective: To evaluate the prevalence of biological abnormalities leading to secondary osteoporosis in recently fractured patients.

Methods: Adults older than 50, hospitalized for a nonvertebral fracture from July 2015 to October 2016, were assessed for bone fragility contributors in the Orthopedics Department. Bone mineral density (BMD) measurements and Vertebral Fracture assessment (VFA) were performed within 3 months. Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.03.009DOI Listing
April 2019
1 Read

Evaluation of bone health in patients with adrenal tumors.

Curr Opin Endocrinol Diabetes Obes 2019 Apr 9. Epub 2019 Apr 9.

Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.

Purpose Of Review: Adrenal tumors occur in 5% of population with higher prevalence in elderly. Patients with adrenal tumors present with overt hormonal excess in up to 15% of cases, and mild autonomous cortisol secretion in 30-40% of cases. Overt Cushing syndrome, mild autonomous cortisol secretion, pheochromocytoma, and primary aldosteronism have been associated with higher cardiovascular morbidity and mortality. Read More

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http://dx.doi.org/10.1097/MED.0000000000000478DOI Listing
April 2019
1 Read

Relationship between multimorbidity, demographic factors and mortality: findings from the UK Biobank cohort.

BMC Med 2019 Apr 10;17(1):74. Epub 2019 Apr 10.

General Practice and Primary Care, Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, 1 Horselethill Road, Glasgow, G12 9LX, UK.

Background: Multimorbidity is associated with higher mortality, but the relationship with cancer and cardiovascular mortality is unclear. The influence of demographics and type of condition on the relationship of multimorbidity with mortality remains unknown. We examine the relationship between multimorbidity (number/type) and cause of mortality and the impact of demographic factors on this relationship. Read More

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http://dx.doi.org/10.1186/s12916-019-1305-xDOI Listing
April 2019
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Vertebral Fractures among Patients Referred for Bone Densitometry Screening in Dubai Primary Health Care Facilities.

Int J Rheumatol 2019 6;2019:7974534. Epub 2019 Mar 6.

Strategy & Governance Department, Dubai Health Authority, Dubai, UAE.

Vertebral fractures are one of the most common fractures associated with low bone mineral density. However two-thirds to three-fourths of patients with vertebral fractures are not clinically recognized. The objective of this study was to determine the prevalence of vertebral fractures in patients referred for bone densitometry and the most common site of fracture. Read More

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http://dx.doi.org/10.1155/2019/7974534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431384PMC
March 2019
2 Reads

Abaloparatide for risk reduction of nonvertebral and vertebral fractures in postmenopausal women with osteoporosis: a network meta-analysis.

Osteoporos Int 2019 Apr 6. Epub 2019 Apr 6.

Radius Health, Inc., Waltham, MA, USA.

This network meta-analysis assessed the efficacy of abaloparatide versus other treatment options to reduce the risk of fractures in women with postmenopausal osteoporosis. The analysis indicates that abaloparatide reduces the risk of fractures in women with postmenopausal osteoporosis versus placebo and compared with other treatment options.

Introduction: This network meta-analysis (NMA) assessed the relative efficacy of abaloparatide versus other treatments to reduce the risk of fractures in women with postmenopausal osteoporosis (PMO). Read More

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http://dx.doi.org/10.1007/s00198-019-04947-2DOI Listing
April 2019
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Project ECHO: Telehealth to Expand Capacity to Deliver Best Practice Medical Care.

Rheum Dis Clin North Am 2019 May 8;45(2):303-314. Epub 2019 Mar 8.

Project ECHO, University of New Mexico Health Sciences Center, 1650 University Boulevard NE Albuquerque, NM 87102, USA.

Project ECHO (Extension for Community Healthcare Outcomes) was developed at the University of New Mexico Health Sciences Center to educate health care professionals in underserved communities to treat chronic complex diseases, allowing patients to receive better care, closer to home, with greater convenience, and at lower cost than referral to a specialty center. Videoconferencing technology is used to create learning networks, with case-based discussions as the primary method of education. The 3-year experience of Bone Health TeleECHO, a strategy to improve the care of osteoporosis and reduce the large treatment gap, is discussed. Read More

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http://dx.doi.org/10.1016/j.rdc.2019.01.003DOI Listing
May 2019
2 Reads

Biochemical and immunohistochemical investigations on bone formation and remodelling in ovariectomized rats with tamoxifen citrate administration.

Folia Morphol (Warsz) 2019 Apr 5. Epub 2019 Apr 5.

Department of Histology and Embryology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.

Osteoporosis results with the imbalance between osteoblastic formation and osteoclastic resorption, resulting in susceptibility to bone fractures. Ovariectomy leads to osteoporosis by triggering alterations in bone formation and structure. Tamoxifen as an anti-estrogen is used for adjuvant therapy especially in metastatic diseases and known to have a bone mass protective effect after ovariectomy. Read More

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http://dx.doi.org/10.5603/FM.a2019.0035DOI Listing
April 2019
1 Read

ACTH-producing adenoma of the pituitary gland manifesting as severe insulin resistance.

J Surg Case Rep 2019 Mar 29;2019(3):rjz070. Epub 2019 Mar 29.

Campbell University, School of Osteopathic Medicine, Novant Health Presbyterian, Internal Medicine, Charlotte, NC, USA.

Pituitary adenomas are commonly benign neoplasms which may manifest with a wide variety of symptomatology. Typically, ACTH- producing tumors of the pituitary gland present with central fat deposition, abdominal striae, moon facies, buffalo hump, osteoporosis, hypertension, hirsutism, gonadal dysfunction, immunosuppression, and less commonly with hyperglycemia due to insulin resistance. We report the case of a 58-year-old male patient with an ACTH producing pituitary microadenoma and type 2 Diabetes Mellitus (DM) whose primary presenting symptom was increasing insulin resistance despite appropriate adjustments to his insulin therapy. Read More

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https://academic.oup.com/jscr/article/doi/10.1093/jscr/rjz07
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http://dx.doi.org/10.1093/jscr/rjz070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439515PMC
March 2019
4 Reads

Evaluation of the need for a fracture liaison service in a patient-centered medical home.

J Am Pharm Assoc (2003) 2019 Apr 1. Epub 2019 Apr 1.

Objectives: To evaluate the need for a fracture liaison service (FLS) based on postfracture care in a patient-centered medical home (PCMH).

Methods: Patients in a PCMH who presented to a local 763-bed community teaching hospital with fragility fracture of the hip, spine, or forearm between January 1, 2013, and December 31, 2014, were identified using ICD-9 codes. A retrospective chart review of inpatient and outpatient medical records 2 years before the fracture and 1 year afterward was conducted. Read More

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http://dx.doi.org/10.1016/j.japh.2019.02.010DOI Listing
April 2019
3 Reads

Forearm bone density is not elevated in Inuit women with impaired fasting glucose or type 2 diabetes mellitus.

Int J Circumpolar Health 2019 Dec;78(1):1601056

a School of Human Nutrition , McGill University , Ste-Anne-de-Bellevue , QC , Canada.

Bone mineral density (BMD) and fracture risk are elevated in adults with impaired fasting glucose (IFG) or type 2 diabetes mellitus (T2D). This study aimed to compare bone health among Inuit women with IFG, T2D and normoglycemia. The study included Inuit women (≥40 y) with IFG (n = 57), T2D (n = 72) or normoglycemia (n = 340) from the International Polar Year Inuit Health Survey 2007-2008 in Canada. Read More

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http://dx.doi.org/10.1080/22423982.2019.1601056DOI Listing
December 2019
2 Reads

Abdominal aortic calcification, bone mineral density and fractures: a systematic review and meta-analysis protocol.

BMJ Open 2019 Apr 2;9(4):e026232. Epub 2019 Apr 2.

The University of Sydney, Centre for Kidney Research, School of Public Health, Sydney Medical School, Children's Hospital at Westmead, New South Wales, Australia.

Introduction: Abdominal aortic calcification (AAC) is associated with low bone mass and increased fracture risk. Two previous meta-analyses have investigated the association between AAC and fracture. However, these meta-analyses only identified articles until December 2016, undertook limited searches and did not explore potential sources of between-study heterogeneity. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026232DOI Listing
April 2019
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Prevalence of and factors associated with primary medication non-adherence in chronic disease: A systematic review and meta-analysis.

Int J Clin Pract 2019 Apr 3:e13350. Epub 2019 Apr 3.

Singapore General Hospital, Rheumatology and Immunology, Singapore.

Background: Primary medication non-adherence (PMN), defined as failure to obtain newly prescribed medications, results in adverse clinical and economic outcomes. We aimed to (1) assess the prevalence of PMN in six common chronic diseases: asthma and/ or chronic obstructive pulmonary disease, depression, diabetes mellitus, hyperlipidemia, hypertension and osteoporosis; (2) identify and categorize factors associated with PMN; (3) explore characteristics that contributed to heterogeneity between studies.

Methods: We performed a systematic search in MEDLINE, Embase, Cochrane Library, CINAHL, and PsycINFO. Read More

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http://dx.doi.org/10.1111/ijcp.13350DOI Listing
April 2019
5 Reads

Tibial shaft fractures in Finland between 1997 and 2014.

Injury 2019 Mar 21. Epub 2019 Mar 21.

Division of Orthopaedics and Traumatology, Department of Trauma, Musculoskeletal Surgery and Rehabilitation, Tampere University Hospital, Tampere, Finland; Faculty of Medicine and Health Technology, Tampere University, Teiskontie 35, PL2000, Tampere, 33521, Finland. Electronic address:

Introduction: Tibial shaft fracture is common, accounting for 2% of all adult fractures. Large epidemiological follow ups are lacking and previous studies have shown great variation in incidence rates and trends. The aim of this population-based nationwide study was to analyze all tibial shaft fractures in Finland in 1997-2014 and to provide an update on current epidemiological data. Read More

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http://dx.doi.org/10.1016/j.injury.2019.03.034DOI Listing
March 2019
2 Reads

Overwhelming Underuse of Bisphosphonates in French Nursing Home Residents After Proximal Femoral Fracture.

J Nutr Health Aging 2019 ;23(4):378-380

Paul Le Floch, CHRU de Brest, Brest, France,

Objective: To evaluate the prescription of bisphosphonates in female nursing home residents aged 75 and older with a history of proximal femoral fracture.

Design: Observational descriptive study, led in Brest, France, between June and August 2015.

Setting: 12 nursing homes in Brest, France. Read More

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http://dx.doi.org/10.1007/s12603-019-1169-yDOI Listing
January 2019
1 Read

Recovery Kinetics following Spinal Deformity Correction: A Comparison of Isolated Cervical, Thoracolumbar, and Combined Deformity Morphometries.

Spine J 2019 Mar 28. Epub 2019 Mar 28.

Department of Orthopaedic Surgery, Denver International Spine Center, Denver, CO, USA.

Background Context: The postoperative recovery patterns of cervical deformity patients, thoracolumbar deformity patients, and patients with combined cervical and thoracolumbar deformities, all relative to one another, is not well understood. Clear, objective benchmarks are needed to quantitatively define a "good" versus a "bad" postoperative recovery across multiple follow-up visits, varying deformity types, and guide expectations.

Purpose: To objectively define and compare the complete 2-year postoperative recovery process amongst operative cervical only, thoracolumbar only, and combined deformity patients using area-under-the-curve (AUC) methodology. Read More

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http://dx.doi.org/10.1016/j.spinee.2019.03.006DOI Listing
March 2019
3 Reads
2.426 Impact Factor

Best Practices for Conducting Observational Research to Assess the Relation between Nutrition and Bone: An International Working Group Summary.

Adv Nutr 2019 Mar 30. Epub 2019 Mar 30.

Department of Nutrition Science, Purdue University, West Lafayette, IN.

Diet is a modifiable factor that can affect bone strength and integrity, and the risk of fractures. Currently, a hierarchy of scientific evidence contributes to our understanding of the role of diet on bone health and fracture risk. The strength of evidence is generally based on the type of study conducted, the quality of the methodology employed, the rigor and integrity of the data collected and analysis plan, and the transparency and completeness of the results. Read More

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http://dx.doi.org/10.1093/advances/nmy111DOI Listing
March 2019
2 Reads

A comparative retrospective study of locking plate fixation versus a dedicated external fixator of 3- and 4-part proximal humerus fractures: Results after 5 years.

Injury 2019 Mar 9. Epub 2019 Mar 9.

Department of Basic Medical Sciences, Neurosciences and Sensory Organs University of Bari, Italy.

Introduction: Fractures of the proximal humerus (PHF) represent a common injury among orthopedic department; especially for three- and four-part fractures no consensus about the best treatment is still achieved. The aim of our study was to compare clinical and radiological outcomes in patients alternatively treated with plates and screws or external fixation system for a type III-IV proximal humerus fracture.

Material And Methods: Sixty-nine patients went surgery for type III-IV PHF between January 2011 and January 2014. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00201383193005
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http://dx.doi.org/10.1016/j.injury.2019.01.051DOI Listing
March 2019
2 Reads

Improving the accuracy of medication adherence measures using linked prescription and dispensation data: findings from the ESOSVAL cohort of patients treated with osteoporosis drugs.

Curr Med Res Opin 2019 Mar 29. Epub 2019 Mar 29.

a Health Services Research Unit , Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO) , Valencia , Spain.

Objective: We compare estimates of Proportion of Days Covered (PDC) based on dispensation-only data versus linked prescription and dispensation information, and we analyse their differences in a real-world cohort of patients with osteoporosis.

Methods: Prospective cohort study. We compared four alternative measures of PDC, using dispensation-only data: a) with a fixed assessment interval and b) censoring the assessment interval at the moment of the last refill, and using linked prescription and dispensation data: c) considering a minimum prescription gap of three months to interpret interruption by the physician and d) considering any prescription gap. Read More

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http://dx.doi.org/10.1080/03007995.2019.1601944DOI Listing
March 2019
1 Read

Secondary prevention of minor trauma fractures: the effects of a tailored intervention-an observational study.

Arch Osteoporos 2019 Mar 29;14(1):44. Epub 2019 Mar 29.

Department of Orthopaedic and Trauma Surgery, Cantonal Hospital Lucerne, Spitalstrasse, Lucerne, 6000, Switzerland.

Introduction: Minor trauma fractures (MTF) in the elderly are associated with an increase in mortality, morbidity, and the risk of subsequent fractures. Often, these patients who sustain MTF have an underlying bone disease, such as osteopenia or osteoporosis. Osteoporosis is known to be underdiagnosed and undertreated, and adequate treatment is essential to reduce the occurrence of MTFs. Read More

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http://dx.doi.org/10.1007/s11657-019-0595-0DOI Listing
March 2019
1 Read

Bone mineral density, bone turnover markers, and incident fractures in de novo kidney transplant recipients.

Kidney Int 2019 Mar 4. Epub 2019 Mar 4.

Department of Nephrology and Renal Transplantation, University Hospitals Leuven and Laboratory of Nephrology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.

Kidney transplant recipients are at increased risk of fractures. This prospective observational study investigated whether areal bone mineral density (aBMD) as assessed by dual-energy x-ray absorptiometry can predict incident fragility fractures in de novo kidney transplant recipients and whether bone turnover markers increase diagnostic accuracy. Parameters of bone mineral metabolism including parathyroid hormone (PTH), fibroblast growth factor 23, sclerostin, calcidiol and calcitriol, and bone turnover markers were assessed in blood samples collected immediately prior to kidney transplantation in 518 adult recipients. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.024DOI Listing
March 2019
1 Read

Office-Based Kyphoplasty: A Viable Option Using Local Anesthesia with Oral Sedation.

Pain Physician 2019 03;22(2):177-185

Tallahassee Orthopedic Clinic, Tallahassee, FL.

Background: Vertebral compression fractures (VCFs) can be conservatively treated with pain management, bracing, and bed rest, or treated surgically with a kyphoplasty or vertebroplasty procedure.

Objectives: The objective of this retrospective review was to assess the viability, safety, and efficacy of using local anesthesia with oral sedation for an office-based kyphoplasty procedure.

Study Design: A retrospective review. Read More

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March 2019
1 Read

Adrenocortical hypofunction with simultaneous primary aldosteronism: A case report.

Medicine (Baltimore) 2019 Mar;98(13):e15033

Rationale: Cases of adrenocortical hyperfunction combined with primary aldosteronism have been reported in the literature, and the underlying mechanism involves the secretion of aldosterone and glucocorticoids by a tumor or an adenoma. However, adrenocortical hypofunction and coexisting primary aldosteronism have not been reported until now. Herein, we report a case of adrenocortical hypofunction combined with primary aldosteronism. Read More

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http://dx.doi.org/10.1097/MD.0000000000015033DOI Listing
March 2019
3 Reads

Age-Related Variances in Patients with Tibial Plateau Fractures.

J Knee Surg 2019 Mar 27. Epub 2019 Mar 27.

Department of Orthopaedic Surgery, University of Missouri School of Medicine, Columbia, Missouri.

Tibial plateau fractures account for approximately 8% of fractures in the elderly population. Treatment strategies in the elderly are similar to those for younger patients; however, practitioners must account for the elevated comorbidity burden in this population. To date, few studies have analyzed age-based outcomes in patients with tibial plateau fractures. Read More

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http://dx.doi.org/10.1055/s-0039-1683893DOI Listing
March 2019
2 Reads

Predictors of nephrolithiasis, osteoporosis and mortality in primary hyperparathyroidism.

J Clin Endocrinol Metab 2019 Mar 27. Epub 2019 Mar 27.

Edinburgh Centre for Endocrinology and Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK.

Context: Primary Hyperparathyroidism (PHPT) has a prevalence of 0.86% and is associated with increased risk of nephrolithiasis and osteoporosis. PHPT may also be associated with an increased risk of cardiovascular disease and mortality. Read More

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http://dx.doi.org/10.1210/jc.2018-02483DOI Listing
March 2019
2 Reads

Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing's Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China.

Int J Endocrinol 2019 19;2019:7159696. Epub 2019 Feb 19.

Key Laboratory of Endocrinology of National Health Commission of People's Republic of China, Beijing 100730, China.

Purpose: To investigate the demographic characteristics, etiology, and comorbidities of Cushing's syndrome (CS) patients at a large medical center in China.

Methods: Records on CS patients discharged from 2008 to 2017 were retrieved from the hospital discharge abstract database (DAD) using ICD-10 codes. Demographic characteristics, etiology, and comorbidity data were analyzed. Read More

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http://dx.doi.org/10.1155/2019/7159696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399544PMC
February 2019
2 Reads

Increased glycolysis mediates Wnt7b-induced bone formation.

FASEB J 2019 Mar 26:fj201900201RR. Epub 2019 Mar 26.

Department of Orthopedic Surgery, School of Medicine, Washington University, St. Louis, Missouri, USA.

Wingless/integrated (Wnt) signaling has emerged as a major mechanism for promoting bone formation and a target pathway for developing bone anabolic agents against osteoporosis. However, the downstream events mediating the potential therapeutic effect of Wnt proteins are not fully understood. Previous studies have indicated that increased glycolysis is associated with osteoblast differentiation in response to Wnt signaling, but direct genetic evidence for the importance of glucose metabolism in Wnt-induced bone formation is lacking. Read More

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http://dx.doi.org/10.1096/fj.201900201RRDOI Listing
March 2019
1 Read

ACOG Committee Opinion No. 774: Opportunistic Salpingectomy as a Strategy for Epithelial Ovarian Cancer Prevention.

Authors:

Obstet Gynecol 2019 Apr;133(4):e279-e284

Opportunistic salpingectomy may offer obstetrician-gynecologists and other health care providers the opportunity to decrease the risk of ovarian cancer in their patients who are already undergoing pelvic surgery for benign disease. By performing salpingectomy when patients undergo an operation during which the fallopian tubes could be removed in addition to the primary surgical procedure (eg, hysterectomy), the risk of ovarian cancer is reduced. Although opportunistic salpingectomy offers the opportunity to significantly decrease the risk of ovarian cancer, it does not eliminate the risk of ovarian cancer entirely. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003164DOI Listing
April 2019
4 Reads

ACOG Committee Opinion No. 774 Summary: Opportunistic Salpingectomy as a Strategy for Epithelial Ovarian Cancer Prevention.

Authors:

Obstet Gynecol 2019 Apr;133(4):842-843

Opportunistic salpingectomy may offer obstetrician-gynecologists and other health care providers the opportunity to decrease the risk of ovarian cancer in their patients who are already undergoing pelvic surgery for benign disease. By performing salpingectomy when patients undergo an operation during which the fallopian tubes could be removed in addition to the primary surgical procedure (eg, hysterectomy), the risk of ovarian cancer is reduced. Although opportunistic salpingectomy offers the opportunity to significantly decrease the risk of ovarian cancer, it does not eliminate the risk of ovarian cancer entirely. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003165DOI Listing
April 2019
2 Reads

Mayer-Rokitansky-Küster-Hauser syndrome with a uterine cervix and normal vagina associated with gonadal dysgenesis in a 46,XX female.

J Obstet Gynaecol Res 2019 Mar 26. Epub 2019 Mar 26.

Department of Obstetrics and Gynecology, Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, Tokyo, Japan.

Coexistence of Mayer-Rokitansky-Küster-Hauser syndrome and gonadal dysgenesis is extremely rare, and a case of Mayer-Rokitansky-Küster-Hauser syndrome with a uterine cervix and normal vagina has not been reported. Here, we report such a case associated with gonadal dysgenesis. A 17-year-old female presented with primary amenorrhea and undeveloped secondary sexual characteristics. Read More

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http://dx.doi.org/10.1111/jog.13956DOI Listing
March 2019
1 Read

Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells.

Aging (Albany NY) 2019 Mar;11(6):1791-1803

Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

Extracellular vesicles (EVs) are known to play important roles in cell-cell communication. Here we investigated the role of muscle-derived EVs and their microRNAs in the loss of bone stem cell populations with age. Aging in male and female C57BL6 mice was associated with a significant increase in expression of the senescence-associated microRNA miR-34a-5p (miR-34a) in skeletal muscle and in serum -derived EVs. Read More

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http://dx.doi.org/10.18632/aging.101874DOI Listing
March 2019
3 Reads

Efficacy of Pharmacological Therapies for the Prevention of Fractures in Postmenopausal Women: A Network Meta-Analysis.

J Clin Endocrinol Metab 2019 May;104(5):1623-1630

Evidence-Based Practice Research Program, Mayo Clinic, Rochester, Minnesota.

Background: Osteoporosis and osteopenia are associated with increased fracture incidence in postmenopausal women. We aimed to determine the comparative effectiveness of various available pharmacological therapies.

Methods: We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ISI Web of Science, and Scopus for randomized controlled trials that enrolled postmenopausal women with primary osteoporosis and evaluated the risk of hip, vertebral, or nonvertebral fractures. Read More

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http://dx.doi.org/10.1210/jc.2019-00192DOI Listing
May 2019
4 Reads
6.209 Impact Factor

Adherence to bisphosphonates in the general population: a study in patients referred to a primary care service.

Arch Osteoporos 2019 Mar 21;14(1):42. Epub 2019 Mar 21.

Department of Internal Medicine and Medical Disciplines, "Sapienza" Rome University, Viale del Policlinico 155, 00161, Rome, Italy.

Purpose: The aim of the study was to evaluate the adherence to treatment with bisphosphonates in women with postmenopausal osteoporosis referred to a primary care clinic.

Methods: A total of 7257 outpatients were referred to the primary care service where the study was conducted. We retrieved data of postmenopausal women to which bisphosphonates have been prescribed in the period January 1, 2000-December 31, 2014, and analyzed the group of patients who had discontinued the drug. Read More

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http://link.springer.com/10.1007/s11657-019-0593-2
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http://dx.doi.org/10.1007/s11657-019-0593-2DOI Listing
March 2019
4 Reads

Quantification of Risk Factors for Cervical Ossification of the Posterior Longitudinal Ligament in Korean Populations: A Nationwide Population-Based Case-Control Study.

Spine (Phila Pa 1976) 2019 Mar 1. Epub 2019 Mar 1.

Department of Rehabilitation Medicine, BundangJesaeng General Hospital, Gyeonggi-do, Republic of Korea.

Study Design: Case-control study.

Objectives: To quantify risk factors for cervical Ossification of the posterior longitudinal ligament (OPLL) using a large nationwide cohort in Korea, a country with a high prevalence of OPLL.

Summary Of Background Data: OPLL is a pathological calcification of the posterior longitudinal ligament of the spine. Read More

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http://dx.doi.org/10.1097/BRS.0000000000003027DOI Listing
March 2019
1 Read
2.297 Impact Factor

Repeat decompression and fusions following posterolateral fusion versus posterior/transforaminal lumbar interbody fusion for lumbar spondylosis: a national database study.

Sci Rep 2019 Mar 20;9(1):4926. Epub 2019 Mar 20.

Department of Orthopaedic Surgery, Hallym University Sacred Heart Hospital, Medical College of Hallym University, 22 Gwanpyeong-ro 170 beon-gi, Dongan-gu, Anyang-si, Gyeonggi-do, 14068, Republic of Korea.

There is a low incidence of reoperation after surgery. It is difficult to detect statistical differences between reoperation rates of different lumbar fusion surgeries. National population-based databases provide large, longitudinally followed cohorts that may help overcome this challenge. Read More

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http://dx.doi.org/10.1038/s41598-019-41366-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426932PMC
March 2019
2 Reads

Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density.

Nat Commun 2019 03 19;10(1):1260. Epub 2019 Mar 19.

Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, 19104, PA, USA.

Osteoporosis is a devastating disease with an essential genetic component. GWAS have discovered genetic signals robustly associated with bone mineral density (BMD), but not the precise localization of effector genes. Here, we carry out physical and direct variant to gene mapping in human mesenchymal progenitor cell-derived osteoblasts employing a massively parallel, high resolution Capture C based method in order to simultaneously characterize the genome-wide interactions of all human promoters. Read More

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http://dx.doi.org/10.1038/s41467-019-09302-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425012PMC
March 2019
3 Reads

Connective Tissue and Age-Related Diseases.

Subcell Biochem 2019;91:281-310

Department of Pathology, College of Veterinary Medicine, The University of Georgia and AU/UGA Medical Partnership, Athens, GA, USA.

We begin this chapter by describing normal characteristics of several pertinent connective tissue components, and some of the basic changes they undergo with ageing. These alterations are not necessarily tied to any specific disease or disorders, but rather an essential part of the normal ageing process. The general features of age-induced changes, such as skin wrinkles, in selected organs with high content of connective or soft tissues are discussed in the next part of the chapter. Read More

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http://dx.doi.org/10.1007/978-981-13-3681-2_11DOI Listing
January 2019
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Management of Fragility Hip Fractures: Our Institutional Experience.

Geriatr Orthop Surg Rehabil 2019 11;10:2151459319828618. Epub 2019 Mar 11.

Department of Orthopaedic Surgery, Virginia Commonwealth University, Richmond, VA, USA.

Introduction: Approximately 320 000 fragility hip fractures are sustained in the United States annually, resulting in substantial morbidity and mortality as well as significant economic burden on the health-care system. Nevertheless, a majority of these patients are not screened and do not receive treatment for osteoporosis. The objective of this study was to evaluate rates of osteoporosis screening and treatment in our institution and compare them to those reported in the literature. Read More

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http://dx.doi.org/10.1177/2151459319828618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413423PMC
March 2019
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Functional characterization of the C7ORF76 genomic region, a prominent GWAS signal for osteoporosis in 7q21.3.

Bone 2019 Mar 14;123:39-47. Epub 2019 Mar 14.

Department of Genetics, Microbiology and Statistics, Facultat de Biologia, Universitat de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, IBUB, IRSJD, Barcelona, Catalonia, Spain. Electronic address:

Genome-wide association studies (GWAS) have repeatedly identified genetic variants associated with bone mineral density (BMD) and osteoporotic fracture in non-coding regions of C7ORF76, a poorly studied gene of unknown function. The aim of the present study was to elucidate the causality and molecular mechanisms underlying the association. We re-sequenced the genomic region in two extreme BMD groups from the BARCOS cohort of postmenopausal women to search for functionally relevant variants. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.014DOI Listing
March 2019
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How do glucocorticoids used in rheumatic disease affect body weight? A narrative review of the evidence.

Arthritis Care Res (Hoboken) 2019 Mar 15. Epub 2019 Mar 15.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, School of Biological Sciences, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

Glucocorticoids (GCs) are widely used to effectively treat inflammatory disease, however GCs have a number of recognised side effects. It has been shown that patients and clinicians view these side effects differently, with clinicians most concerned with serious side effects such as osteoporosis and diabetes. Consequently these side effects are well researched with clinical guidelines and recommendations. Read More

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http://dx.doi.org/10.1002/acr.23879DOI Listing
March 2019
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Fall Ascertainment and Development of a Risk Prediction Model Using Electronic Medical Records.

J Am Geriatr Soc 2019 Mar 15. Epub 2019 Mar 15.

Center for Health Research, Kaiser Permanente Hawaii, Honolulu, Hawaii.

Objectives: To examine the use of electronic medical record (EMR) data to ascertain falls and develop a fall risk prediction model in an older population.

Design: Retrospective longitudinal study using 10 years of EMR data (2004-2014). A series of 3-year cohorts included members continuously enrolled for a minimum of 3 years, requiring 2 years pre-fall (no previous record of a fall) and a 1-year fall risk period. Read More

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http://dx.doi.org/10.1111/jgs.15872DOI Listing
March 2019
2 Reads

Hypermineralization in the femoral neck of the elderly.

Acta Biomater 2019 Apr 12;89:330-342. Epub 2019 Mar 12.

Department of Materials Engineering, University of British Columbia, Vancouver, BC, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada; Centre for Hip Health and Mobility, Vancouver, BC, Canada. Electronic address:

Hip fragility depends on the decline in bone mass as well as changes in bone microstructure and the properties of bone mineral and organic matrix. Although it is well-established that low bone mass or osteoporosis is a key factor in hip fracture risk, it is striking to observe that 92% of 24 patients who have sustained an intracapsular hip fracture showed hypermineralization at the superior-anterior quadrant, a critical region associated with increased hip fracture risk. In-depth material studies on a total of 12 human cadaver femurs revealed increased degree of mineralization in the hypermineralized tissue: calcium weight percentage as measured by quantitative backscattered electron imaging increased by approximately 15% compared with lamellar bone; mineral-to-matrix ratio obtained by Raman microspectroscopy imaging also increased. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.020DOI Listing
April 2019
4 Reads

Clinical Update on Osteoporosis.

J Midwifery Womens Health 2019 Mar 14. Epub 2019 Mar 14.

Vanderbilt University School of Nursing, Nashville, TN.

Osteoporosis is described as a silent disease prior to fracture, and the sequelae of an osteoporotic fracture can be devastating. Primary care providers should routinely assess and remediate bone health during wellness visits for women aged at least 50 years. Assessment includes review of a variety of risk factors, bone density testing, and an online fracture risk assessment tool calculation. Read More

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http://dx.doi.org/10.1111/jmwh.12954DOI Listing
March 2019
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Decrease of GSK3β Ser-9 Phosphorylation Induced Osteoblast Apoptosis in Rat Osteoarthritis Model.

Curr Med Sci 2019 Feb 13;39(1):75-80. Epub 2019 Mar 13.

Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

Nowadays, the cumulative intake of glucocorticoids has become the most common pathogenic factor for non-traumatic osteonecrosis of the femoral head (ONFH). Apoptosis of osteoblasts is considered as the main reason of ONFH at the molecular level. Glycogen synthase kinase 3β (GSK3β) is an important regulator of cellular differentiation and apoptosis pathway, which can modulate the balance between osteoblasts and osteoclasts. Read More

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http://dx.doi.org/10.1007/s11596-019-2002-xDOI Listing
February 2019
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Predictive factors for the efficacy of denosumab in postmenopausal Japanese women with non-metastatic breast cancer receiving adjuvant aromatase inhibitors: a combined analysis of two prospective clinical trials.

J Bone Miner Metab 2019 Mar 13. Epub 2019 Mar 13.

Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Aromatase inhibitors (AIs) are the gold standard therapy for breast cancer in postmenopausal women. AI suppresses the conversion of androgens to estrogens; however, this results in osteopenia, osteoporosis, and bone fracture, thus reducing the patient's quality of life. The use of adjuvant denosumab reduces the risk of clinical fractures in postmenopausal patients with breast cancer receiving AI. Read More

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http://dx.doi.org/10.1007/s00774-018-00985-8DOI Listing
March 2019
3 Reads

Evidence of patient beliefs, values, and preferences is not provided in osteoporosis clinical practice guidelines.

Osteoporos Int 2019 Mar 11. Epub 2019 Mar 11.

Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, 3D10, 3280 Hospital Drive NW, Calgary, Alberta, T2N 4Z6, Canada.

We examined how patient beliefs, values, and preferences (BVPs) were included and conceptualized in international osteoporosis guidelines. The majority of guidelines did not mention BVPs. When mentioned, BVPs were conceptualized as preference for one medication over another. Read More

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http://dx.doi.org/10.1007/s00198-019-04913-yDOI Listing
March 2019
2 Reads

Efficacy of Jintiange Capsules in the Treatment of Osteoporosis: A Network Meta-analysis.

Orthop Surg 2019 Mar 10. Epub 2019 Mar 10.

Editorial Office of Orthopaedic Surgery, Tianjin Hospital, Tianjin, China.

Objective: To evaluate the efficacy of Jintiange capsules and Jintiange combined with other therapies in the treatment of osteoporosis.

Methods: A systematic review of the literature was conducted through databases including China National Knowledge Infrastructure (CNKI), the VIP Database for Chinese Technical Periodicals (VIP), Wanfang, and PubMed from inception to April 2018. Network meta-analysis was used to determine the relative efficacy of related treatments on osteoporosis. Read More

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http://doi.wiley.com/10.1111/os.12439
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http://dx.doi.org/10.1111/os.12439DOI Listing
March 2019
8 Reads