7,876 results match your criteria Osteoporosis Primary


Cortical Bone Porosity in Rabbit Models of Osteoporosis.

J Bone Miner Res 2020 Jul 2. Epub 2020 Jul 2.

Department of Anatomy, Physiology, and Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Cortical bone porosity is intimately linked with remodeling, is of growing clinical interest, and is increasingly accessible by imaging. Thus, the potential of animal models of osteoporosis (OP) to provide a platform for studying how porosity develops and responds to interventions is tremendous. To date, rabbit models of OP have largely focused on trabecular microarchitecture or bone density; some such as ovariectomy (OVX) have uncertain efficacy and cortical porosity has not been extensively reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbmr.4124DOI Listing

Effect of bisphosphonates or teriparatide on mechanical complications after posterior instrumented fusion for osteoporotic vertebral fracture: a multi-center retrospective study.

BMC Musculoskelet Disord 2020 Jul 1;21(1):420. Epub 2020 Jul 1.

Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Background: The optimal treatment of osteoporosis after reconstruction surgery for osteoporotic vertebral fractures (OVF) remains unclear. In this multicentre retrospective study, we investigated the effects of typically used agents for osteoporosis, namely, bisphosphonates (BP) and teriparatide (TP), on surgical results in patients with osteoporotic vertebral fractures.

Methods: Retrospectively registered data were collected from 27 universities and affiliated hospitals in Japan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12891-020-03452-6DOI Listing

Healthcare Utilization and Prevalence of Symptoms in Women with Menopause: A Real-World Analysis.

Int J Womens Health 2020 3;12:445-454. Epub 2020 Jun 3.

Kahn-Sagol-Maccabi Research and Innovation Institute, Maccabi Healthcare Services, Tel Aviv, Israel.

Objective: Self-reported studies estimated that as many as 50-75% of women experience symptoms during menopause; however, limited real-world clinical data are available to support this observation. The electronic databases of Maccabi Healthcare Services were used to describe the prevalence of menopause symptoms in Israel and to characterize patients with regard to socioeconomic status, comorbidities and use of healthcare services.

Methods: Females aged 45-54 years diagnosed with menopausal symptoms (N=17,046, cumulative incidence of 8% during the study period) were identified from the Maccabi Healthcare Services electronic database and matched to female members without menopause symptoms, one-to-one on birth year and enumeration area. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IJWH.S246113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293420PMC

Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement.

Int J Chron Obstruct Pulmon Dis 2020 15;15:1377-1390. Epub 2020 Jun 15.

NIHR Nottingham BRC Respiratory Theme, School of Medicine, University of Nottingham, City Hospital Campus, Nottingham, UK.

Introduction: Osteoporosis and bone fractures are common in chronic obstructive pulmonary disease (COPD) and contribute significantly to morbidity and mortality. Current national guidance on COPD management recommends addressing bone health in patients, however, does not detail how. This consensus outlines key elements of a structured approach to managing bone health and fracture risk in patients with COPD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/COPD.S233398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311204PMC

Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases.

BMC Musculoskelet Disord 2020 Jun 30;21(1):416. Epub 2020 Jun 30.

Division of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Tianhe District, Guangzhou, 510630, China.

Backgroud: This study is to explore the prevalence of different stages of bone loss and the potential risk factors in rheumatic patients.

Method: A cross-sectional study recruits 1398 rheumatic patients and 302 healthy subjects. Demographic data, blood, and bone mineral density (BMD) tests are collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12891-020-03403-1DOI Listing

Pain characteristics in medication-related osteonecrosis of the jaws.

Support Care Cancer 2020 Jun 29. Epub 2020 Jun 29.

Department of Oral Medicine, Sedation and Maxillofacial Imaging, School of Dental Medicine, Hebrew University-Hadassah medical center, Jerusalem, Israel.

Purpose: To characterise pain from medication-related osteonecrosis of the jaws (MRONJ) and the effects of antimicrobial treatment on it.

Methods: Data from files of patients diagnosed with MRONJ according to the position paper of the American Association of Oral and Maxillofacial Surgeons (2014) and Multinational Association of Supportive Care in Cancer and American Society of Clinical Oncology (2019) were collected retrospectively, including gender, age, primary disease, bone-modifying agents (BMAs)/anti-angiogenics, administration route, involved jaw, location, and exposure size. The patients were treated according to the abovementioned position papers' recommendations, i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00520-020-05600-zDOI Listing

Efficacy of ursodeoxycholic acid combined with prednisolone and immunosuppressant triple therapy in the treatment of refractory primary biliary cholangitis.

Med Clin (Barc) 2020 Jun 26. Epub 2020 Jun 26.

Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, P.R., China. Electronic address:

Background And Aim: To explore the efficacy treatment regimen in refractory PBC.

Methods: Triple treatment including ursodeoxycholic acid, prednisolone and immunosuppressant was prescribed to 47 refractory patients. Biochemistries, immune parameters, non-invasive liver fibrosis assessments were measured during follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.medcli.2020.03.013DOI Listing

Comparable or higher prevalence of comorbidities in antiphospholipid syndrome vs rheumatoid arthritis: a multicenter, case-control study.

Rheumatology (Oxford) 2020 Jun 29. Epub 2020 Jun 29.

Joint Rheumatology Program, Medical School, National and Kapodistrian University of Athens, Athens.

Objectives: Evidence on comorbidity prevalence in antiphospholipid syndrome (APS) and its difference from high comorbidity burden rheumatic diseases is limited. Herein, we compare multiple comorbidities between APS and RA.

Methods: A total of 326 patients from the Greek APS registry [237 women, mean age 48. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/keaa321DOI Listing

Spironolactone reduces biochemical markers of bone turnover in postmenopausal women with primary aldosteronism.

Endocrine 2020 Jun 27. Epub 2020 Jun 27.

Medizinische Klinik und Poliklinik IV, Klinikum der Universität, LMU München, Ziemssenstraße 1, 80336, Munich, Germany.

Context: Primary aldosteronism (PA) is the most frequent form of endocrine hypertension. Besides its deleterious impact on cardiovascular target organ damage, PA is considered to cause osteoporosis.

Patients And Methods: We assessed bone turnover in a subset of 36 postmenopausal women with PA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12020-020-02348-8DOI Listing

Association of orthogeriatric care models with evaluation and treatment of osteoporosis: a systematic review and meta-analysis.

Osteoporos Int 2020 Jun 27. Epub 2020 Jun 27.

Centre for Metabolic Bone Diseases, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

This systematic review and meta-analysis found low-quality evidence that orthogeriatric care is positively associated with diagnosis of osteoporosis, prescription of calcium and vitamin D supplements and bisphosphonates in older hip fracture patients. Evidence on fall and fracture prevention was scarce and inconclusive. Orthogeriatrics may reduce the treatment gap following hip fractures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00198-020-05512-yDOI Listing

Development and evaluation of an osteoarthritis risk model for integration into primary care health information technology.

Int J Med Inform 2020 May 1;141:104160. Epub 2020 May 1.

Department of Computer Science, Department of Epidemiology & Biostatistics, Schulich Interfaculty Program in Public Health, Department of Statistical and Actuarial Sciences, 1151 Richmond Street, Western University, London, Ontario, N6A 3K7, Canada. Electronic address:

Background: We developed and evaluated a prognostic prediction model that estimates osteoarthritis risk for use by patients and practitioners that is designed to be appropriate for integration into primary care health information technology systems. Osteoarthritis, a joint disorder characterized by pain and stiffness, causes significant morbidity among older Canadians. Because our prognostic prediction model for osteoarthritis risk uses data that are readily available in primary care settings, it supports targeting of interventions delivered as part of clinical practice that are aimed at risk reduction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijmedinf.2020.104160DOI Listing

Outcome of osteoporosis evaluation, treatment, and follow-up in patients referred to a specialized outpatient clinic compared to patients in care of general practitioners.

Arch Osteoporos 2020 Jun 25;15(1):97. Epub 2020 Jun 25.

Institute of Clinical Medicine, University of Copenhagen, Blegdansvej 3B, 2200, Copenhagen N, Denmark.

In Denmark, osteoporosis treatment is either handled by general practitioners or at more resource demanding specialist clinics. We evaluated the treatment adherence and persistence in the two settings, which were overall similar. The type of medical support did, however, differ and was provided to two very different patient populations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11657-020-00774-9DOI Listing

A Combined Nutrition and Exercise Intervention Influences Serum Vitamin B-12 and 25-Hydroxyvitamin D and Bone Turnover of Healthy Chinese Middle-Aged and Older Adults.

J Nutr 2020 Jun 26. Epub 2020 Jun 26.

Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands.

Background: Hong Kong faces several public health problems including malnutrition and osteoporosis. Considering the typical Chinese diet and overall low physical activity levels of Chinese adults, timely interventions to improve nutritional status and bone health are needed.

Objectives: We examined the effects of a nutrition plus exercise intervention on serum vitamin B-12 and 25-hydroxyvitamin D [25(OH)D], bone turnover markers, and parathyroid hormone (PTH) concentrations in apparently healthy Chinese middle-aged and older adults. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jn/nxaa149DOI Listing

Effect of Education on Preventive Behaviors of Osteoporosis in Adolescents: A Systematic Review and Meta-Analysis.

Int Q Community Health Educ 2020 Jun 25:272684X20936833. Epub 2020 Jun 25.

Social Determinans of Health Research Center, Tabriz University of Medical Sciences.

Background: Osteoporosis is one of the diseases that can be prevented by correcting health behaviors during adolescence.

Objective: This study was conducted to evaluate the effect of education on preventive behaviors of osteoporosis including physical activity, calcium intake and practice (primary outcomes) and knowledge and attitude related to osteoporosis (secondary outcomes) in adolescents.

Method: A search was done in Cochrane Library, PubMed, Embase, Web of Sciences, Scopus, Google Scholar, SID and Magiran regardless of the time limit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0272684X20936833DOI Listing

Association between Osteoporosis and Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke.

Medicina (Kaunas) 2020 Jun 23;56(6). Epub 2020 Jun 23.

Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, 24253 Chuncheon, Korea.

Little is known about the effect of osteoporosis on cognitive function in the acute and recovery phases of stroke. Early bone mineral density assessments during acute stroke may be a useful marker of cognitive function. We evaluated the effect of osteoporosis on cognitive function at the early and recovery phase of ischemic stroke in patients aged >50 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/medicina56060307DOI Listing

Targeting anti-cancer agents to bone using bisphosphonates.

Bone 2020 Jun 22:115492. Epub 2020 Jun 22.

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA. Electronic address:

The skeleton is affected by numerous primary and metastatic solid and hematopoietic malignant tumors, which can cause localized sites of osteolysis or osteosclerosis that can weaken bones and increase the risk of fractures in affected patients. Chemotherapeutic drugs can eliminate some tumors in bones or reduce their volume and skeletal-related events, but adverse effects on non-target organs can significantly limit the amount of drug that can be administered to patients. In these circumstances, it may be impossible to deliver therapeutic drug concentrations to tumor sites in bones. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2020.115492DOI Listing

Methylpiperidinopyrazole Attenuates Estrogen-Induced Mitochondrial Energy Production and Subsequent Osteoblast Maturation via an Estrogen Receptor Alpha-Dependent Mechanism.

Molecules 2020 Jun 22;25(12). Epub 2020 Jun 22.

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.

An estrogen deficiency is the main cause of osteoporosis in postmenopausal women. In bone remodeling, estrogen receptors (ERs) can mediate estrogen-transducing signals. Methylpiperidinopyrazole (MPP) is a highly specific antagonist of ER-alpha (ERα). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules25122876DOI Listing

UNDERSTANDING OSTEOPOROSIS SCREENING PRACTICES IN MEN: A NATIONWIDE PHYSICIAN SURVEY.

Endocr Pract 2020 Jun 23. Epub 2020 Jun 23.

From: Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan.

To understand osteoporosis screening practices, particularly in men, by a diverse cohort of physicians, including primary care physicians, endocrinologists and geriatricians. We surveyed randomly selected members of the American Academy of Family Practice (AAFP), Endocrine Society and American Geriatrics Society. Respondents were asked to rate how often they would screen for osteoporosis in four different clinical scenarios by ordering a bone density scan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4158/EP-2020-0123DOI Listing

THE RISK OF BONE FRACTURES IN POST-POLIOMYELITIS PATIENTS TRANSITIONING TO MIDDLE ADULTHOOD.

Endocr Pract 2020 Jun 23. Epub 2020 Jun 23.

Endocrine Institute.

While osteoporotic fractures are reported in up to 40% of adults with post-poliomyelitis syndrome (PPS), clinical guidelines regarding bone mineral density (BMD) and indications for treatment are scarce. We investigated the characteristics of PPS patients, focusing on fractures and osteoporosis as the primary outcomes. A cross-sectional retrospective data analysis from medical records of 204 PPS patients regarding their clinical characteristics and long-term outcome, with emphasis on bone metabolism status. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4158/EP-2020-0102DOI Listing

The Effect of Denosumab on Bone Mass in Super Elderly Patients.

J Bone Metab 2020 May 31;27(2):119-124. Epub 2020 May 31.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: Denosumab is a potent antiresorptive drug leading to significant reduction in the risk of vertebral and non-vertebral fractures in postmenopausal osteoporosis. The effect of denosumab in super-elderly patients lacks data to date and few literature has proven the efficacy to this specific group. The purpose of this study was to determine the effectiveness and safety of denosumab in the super-elderly. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11005/jbm.2020.27.2.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297623PMC

Practical Vitamin D Supplementation Using Machine Learning.

J Bone Metab 2020 May 31;27(2):111-117. Epub 2020 May 31.

Division of Hematology and Oncology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Background: Patients with breast cancer are at increased risk of developing osteoporosis. Maintaining normal levels of vitamin D may decrease the risk of osteoporosis, and vitamin D levels must be corrected in patients who develop osteoporosis before beginning bone modifying agents. Therefore, it is important to correct insufficient vitamin D levels in a timely manner. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11005/jbm.2020.27.2.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297626PMC

Trajectories of Disease Accumulation Using Electronic Health Records.

Stud Health Technol Inform 2020 Jun;270:469-473

Centre for Medical Image Computing, University College London.

Multimorbidity is a major problem for patients and health services. However, we still do not know much about the common trajectories of disease accumulation that patients follow. We apply a data-driven method to an electronic health record dataset (CPRD) to analyse and condense the main trajectories to multimorbidity into simple networks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/SHTI200204DOI Listing

Effect of different hydration doses on renal function in patients with primary osteoporosis treated with zoledronic acid: A hospital-based retrospective cohort study.

Medicine (Baltimore) 2020 Jun;99(25):e20831

Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University.

The objective was to investigate the association of different hydration doses and its effect on renal function in patients with primary osteoporosis treated with zoledronic acid.The subjects with primary osteoporosis treated with zoledronic acid at the First Affiliated Hospital of Chongqing Medical University, China, from January 2015 to December 2018 were included in this study. The subjects were classified according to different hydration doses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000020831DOI Listing

Ginger (Zingiber officinale) and turmeric (Curcuma longa L.) supplementation effects on quality of life, body composition, bone mineral density and osteoporosis related biomarkers and micro-RNAs in women with postmenopausal osteoporosis: a study protocol for a randomized controlled clinical trial.

J Complement Integr Med 2020 Jun 19. Epub 2020 Jun 19.

Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran.

Objectives Phytomedicine is widely suggested for the prevention of chronic disease, but evidence for a favorable effect on bone health is lacking. The present study will investigate the Zingiber officinale (ZO) and Curcuma longa L. (CL) supplementation effects on quality of life, body composition, bone mineral density (BMD) and osteoporosis related biomarkers and micro-RNAs in women with postmenopausal osteoporosis (PMO). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/jcim-2020-0017DOI Listing

Hip Fracture Trends in America Between 2009 and 2016.

Geriatr Orthop Surg Rehabil 2020 28;11:2151459320929581. Epub 2020 May 28.

Rubin Institute for Advanced Orthopedics, Center for Joint Preservation and Replacement, Sinai Hospital of Baltimore, MD, USA.

Background: Hip fractures are a common condition associated with high morbidity and mortality. In this study, we assess (1) yearly incidences, (2) demographic factors, (3) postoperative outcomes, (4) primary diagnoses, and (5) primary procedures.

Materials And Methods: The National Inpatient Sample was queried for patients admitted with hip fractures from 2009 to 2016 (n = 2 761 850). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2151459320929581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285936PMC

Bioinspired Mineral Hydrogels as Nanocomposite Scaffolds for the Promotion of Osteogenic Marker Expression and the Induction of Bone Regeneration in Osteoporosis.

Acta Biomater 2020 Jun 18. Epub 2020 Jun 18.

State Key Lab of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China. Electronic address:

Osteoporosis is one of the most prevalent age-related diseases worldwide and is characterized by a systemic deterioration of bone strength (bone mineral density and bone quality) with a resulting increase in fragility fractures. Due to the complex osteoporotic pathological environment, it is a huge challenge to induce bone regeneration under osteoporosis conditions. In this study, we successfully nanoengineer a bioinspired mineralized hydrogel from the supramolecular assembly of nano-hydroxyapatite, sodium carbonate, and polyacrylic acid, termed as CHAp-PAA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actbio.2020.06.024DOI Listing

Relationship between osteoporosis, sarcopenia, vertebral fracture, and osteosarcopenia in patients with primary biliary cholangitis.

Eur J Gastroenterol Hepatol 2020 Jun 16. Epub 2020 Jun 16.

Core Research Facilities, Research Center for Medical Science, The Jikei University School of Medicine, Tokyo, Japan.

Aim: Bone disorders are serious complications in patients with primary biliary cholangitis (PBC), especially in postmenopausal female patients. Given that osteoporosis interrelates closely with sarcopenia, the concept of osteosarcopenia (coexistence of the two complications) has been established. This study aimed to investigate the relationship between osteoporosis, sarcopenia, vertebral fracture, and osteosarcopenia in PBC patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MEG.0000000000001791DOI Listing

Alliance between selective serotonin reuptake inhibitors and fracture risk: an updated systematic review and meta-analysis.

Eur J Clin Pharmacol 2020 Jun 16. Epub 2020 Jun 16.

Pharmaceutical Medicine, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.

Purpose: In the past few years, several fracture-related events have been reported with chronic use of selective serotonin reuptake inhibitors (SSRIs) throughout the globe. Hence, an updated systematic review and meta-analysis was necessary to ascertain the risk involved. The present work evaluated the association of SSRIs with the risk of fracture in adults. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00228-020-02893-1DOI Listing
June 2020
2.966 Impact Factor

Menopausal Hormone Therapy: a Comprehensive Review.

Curr Atheroscler Rep 2020 Jun 18;22(8):33. Epub 2020 Jun 18.

Emory University School of Medicine, Emory Heart and Vascular Center, Emory Women's Heart Center, Atlanta, GA, USA.

Purpose Of Review: For decades the medical community recommended menopausal hormone therapy (MHT) for prevention of atherosclerotic cardiovascular disease (ASCVD) and osteoporosis in addition to relieving unpleasant vasomotor and genitourinary symptoms. These recommendations were largely based on observational studies. Several large randomized placebo-controlled trials led to the surprising finding that postmenopausal women were at higher risk of cardiovascular disease (CVD) events compared with women in the placebo group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11883-020-00854-8DOI Listing

Pharmacological treatment for managing bone health in axial spondyloarthropathy: systematic review and meta-analysis.

Rheumatol Int 2020 Jun 16. Epub 2020 Jun 16.

Discipline of Physiotherapy, Trinity College Dublin, Dublin, Ireland.

Axial spondyloarthropathy (axSpA) is associated with an increased prevalence of osteoporosis, but no recommendations exist to guide management. This systematic review and meta-analysis aim to assess the efficacy of pharmacological and non-pharmacological interventions on bone mineral density (BMD) in axSpA. Electronic databases were searched from inception to June 2019 for randomised controlled trials (RCTs) and quasi (q)-RCTs with pharmacological and non-pharmacological interventions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00296-020-04623-3DOI Listing

A retrospective multicenter study of bone mineral density in adolescents and adults with Turner syndrome in Japan.

Endocr J 2020 Jun 18. Epub 2020 Jun 18.

Division of Endocrinology and Metabolism, Tokyo Metropolitan Children's Medical Center, Tokyo 183-8561, Japan.

Osteoporosis is one of the clinical features of women with Turner syndrome (TS). The reasons for low bone mineral density (BMD) and increased bone fragility are multifactorial, including estrogen deficiency, X-chromosome abnormalities, and environmental factors. Few, large-scale studies on bone mineral density in either adolescents or adults with TS have been done in Japan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1507/endocrj.EJ20-0083DOI Listing

When primary hyperparathyroidism comes as good news.

Endocrinol Diabetes Metab Case Rep 2020 Jun 4;2020. Epub 2020 Jun 4.

Department of Medicine and Surgery, Endocrine Unit, University of Insubria, Varese, Italy.

Summary: Brown tumors are osteoclastic, benign lesions characterized by fibrotic stroma, intense vascularization and multinucleated giant cells. They are the terminal expression of the bone remodelling process occurring in advanced hyperparathyroidism. Nowadays, due to earlier diagnosis, primary hyperparathyroidism keeps few of the classical manifestations and brown tumors are definitely unexpected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/EDM-20-0046DOI Listing

A pilot project on the management of osteoporosis in primary care: results of the audit cycle.

Br J Gen Pract 2020 Jun;70(suppl 1)

Barking, Havering and Redbridge University Hospitals NHS Trust.

Background: Osteoporosis is a major public health problem with the ageing population in the UK. However, there is no known national algorithm for the management of osteoporosis in primary care. Therefore, a treatment pathway was developed in secondary care for patients in the community. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3399/bjgp20X711653DOI Listing

Molecular mechanosensors in osteocytes.

Bone Res 2020 8;8:23. Epub 2020 Jun 8.

Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, and School of Medicine, Southern University of Science and Technology, Shenzhen, 518055 China.

Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of bone remodeling. In addition to their functions in endocrine regulation and calcium and phosphate metabolism, osteocytes are the major responsive cells in force adaptation due to mechanical stimulation. Mechanically induced bone formation and adaptation, disuse-induced bone loss and skeletal fragility are mediated by osteocytes, which sense local mechanical cues and respond to these cues in both direct and indirect ways. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41413-020-0099-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280204PMC

Identifying and managing osteoporosis before and after COVID-19: rise of the remote consultation?

Osteoporos Int 2020 Jun 16. Epub 2020 Jun 16.

School of Primary, Community and Social Care, Keele University, Newcastle-under-Lyme, UK.

The COVID-19 pandemic is influencing methods of healthcare delivery. In this short review, we discuss the evidence for remote healthcare delivery in the context of osteoporosis.

Introduction: The COVID-19 pandemic has undoubtedly had, and will continue to have, a significant impact on the lives of people living with, and at risk of, osteoporosis and those caring for them. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00198-020-05465-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297512PMC

Public priorities for osteoporosis and fracture research: results from a focus group study.

Arch Osteoporos 2020 Jun 16;15(1):89. Epub 2020 Jun 16.

Primary Care Centre Versus Arthritis, School of Primary, Community and Social Care, Keele University, Stoke-on-Trent, ST5 5BG, UK.

Four focus groups were conducted with members of the public to identify important areas for future osteoporosis research. Participants identified priorities to increase public awareness of osteoporosis, reduce delays in diagnosis, improve communication between healthcare providers and to improve follow-up and information provision about causes of osteoporosis, medication harms and prognosis.

Purpose: Patients and the public must be involved in setting research agendas to ensure relevant and impactful questions are prioritised. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11657-020-00766-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297850PMC

Monoclonal Gammopathy of Undetermined Significance (MGUS)-Not So Asymptomatic after All.

Cancers (Basel) 2020 Jun 12;12(6). Epub 2020 Jun 12.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Monoclonal Gammopathy of Undetermined Significance (MGUS) is considered to be a benign precursor condition that may progress to a lymphoproliferative disease or multiple myeloma. Most patients do not progress to an overt condition, but nevertheless, MGUS is associated with a shortened life expectancy and, in a minority of cases, a number of co-morbid conditions that include an increased fracture risk, renal impairment, peripheral neuropathy, secondary immunodeficiency, and cardiovascular disease. This review aims to consolidate current evidence for the significance of these co-morbidities before considering how best to approach these symptoms and signs, which are often encountered in primary care or within a number of specialties in secondary care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers12061554DOI Listing

MANAGEMENT OF ENDOCRINE DISEASE: Male osteoporosis: diagnosis and management. Should the treatment and target be the same as for female osteoporosis?

Eur J Endocrinol 2020 Jun 1. Epub 2020 Jun 1.

A Ferlin, Department of Clinical and Experimental Sciences, Unit of Endocrinology and Metabolism, University of Brescia, Brescia, Italy.

Male osteoporosis has been neglected for too long time and there is need for a change. This condition is clearly under-estimated, under-diagnosed and under-treated. The diagnosis is often made late in the natural history of the pathology or even after a fracture event. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/EJE-20-0034DOI Listing

Effect of Continuous Glucose Monitoring on Glycemic Control in Adolescents and Young Adults With Type 1 Diabetes: A Randomized Clinical Trial.

JAMA 2020 06;323(23):2388-2396

Jaeb Center for Health Research, Tampa, Florida.

Importance: Adolescents and young adults with type 1 diabetes exhibit the worst glycemic control among individuals with type 1 diabetes across the lifespan. Although continuous glucose monitoring (CGM) has been shown to improve glycemic control in adults, its benefit in adolescents and young adults has not been demonstrated.

Objective: To determine the effect of CGM on glycemic control in adolescents and young adults with type 1 diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.2020.6940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298603PMC

Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors.

Nat Rev Rheumatol 2020 Jul 15;16(7):380-390. Epub 2020 Jun 15.

Primary Care Centre Versus Arthritis, School of Primary, Community and Social Care, Keele University, Keele, UK.

Gout is the most common inflammatory arthritis and occurs when hyperuricaemia, sustained elevation of serum urate levels resulting in supersaturation of body tissues with urate, leads to the formation and deposition of monosodium urate crystals in and around the joints. Recent reports of the prevalence and incidence of gout vary widely according to the population studied and methods employed but range from a prevalence of <1% to 6.8% and an incidence of 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41584-020-0441-1DOI Listing

Effects of bushen qianggu method for primary osteoporosis: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(24):e20697

The Fifth Clinical Medical School, Guangzhou University of Chinese Medicine.

Background: Primary osteoporosis (POP) is one of the most common orthopedic diseases with a high risk of fracture. Effective treatment of POP is of great significance to reduce the rate of disability and improve the quality of life. Bushen qianggu (BSQG) is a classical method of TCM in treating POP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000020697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302671PMC

Targeting autophagy in osteoporosis: From pathophysiology to potential therapy.

Ageing Res Rev 2020 Jun 12;62:101098. Epub 2020 Jun 12.

Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China; Li Ka Shing Health and Science Institute, The Chinese University of Hong Kong, Hong Kong, China; Joint Laboratory of Chinese Academic of Science and Hong Kong for Biomaterials, The Chinese University of Hong Kong, Hong Kong, China; Translational Medicine Research and Development Center, Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, China. Electronic address:

Osteoporosis is a highly prevalent disorder characterized by the loss of bone mass and microarchitecture deterioration of bone tissue, attributed to various factors, including menopause (primary), aging (primary) and adverse effects of relevant medications (secondary). In recent decades, knowledge regarding the etiological mechanisms underpinning osteoporosis emphasizes that bone cellular homeostasis, including the maintenance of cell functions, differentiation, and the response to stress, is tightly regulated by autophagy, which is a cell survival mechanism for eliminating and recycling damaged proteins and organelles. With the important roles in the maintenance of cellular homeostasis and organ function, autophagy has emerged as a potential target for the prevention and treatment of osteoporosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2020.101098DOI Listing

The three-year effect of a single zoledronate infusion on bone mineral density and bone turnover markers following denosumab discontinuation in women with postmenopausal osteoporosis.

Bone 2020 Jun 11;138:115478. Epub 2020 Jun 11.

Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece. Electronic address:

Introduction: In women with postmenopausal osteoporosis denosumab discontinuation is associated with rapid bone loss that could be potentially prevented by a single zoledronate infusion for two years. The longer-term effects, however, of zoledronate treatment are unknown. We aimed to study the effect of a single zoledronate infusion during the third year following denosumab discontinuation, in initially treatment-naive postmenopausal women who became osteopenic after 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2020.115478DOI Listing

Prevalence and factors associated with osteoporosis and fragility fractures in patients with primary Sjögren syndrome.

Rheumatol Int 2020 Aug 12;40(8):1259-1265. Epub 2020 Jun 12.

Rheumatology Department, Hospital Comarcal Alt Penedès, Vilafranca del Penedès, Spain.

This study aimed at determining socio-demographic and clinical factors of primary Sjögren syndrome (pSS) associated with osteoporosis (OP) and fragility fracture. SJOGRENSER is a cross-sectional study of patients with pSS, classified according to American European consensus criteria developed in 33 Spanish rheumatology departments. Epidemiological, clinical, serological and treatment data were collected and a descriptive analysis was conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00296-020-04615-3DOI Listing

Kyphoplasty in the Early Oncologic Diagnosis and Treatment of Vertebral Fractures: A Clinical Study.

Turk Neurosurg 2020 May 9. Epub 2020 May 9.

University of Health Sciences, Gaziosmanpasa Training and Research Hospital, Department of Neurosurgery, Istanbul, Turkey.

Aim: Spinal metastases may cause acute vertebral fracture.Compression fractures may develop in the metastatic vertebra corpus after minor trauma.This retrospective clinical study sought to elucidate the characteristics of kyphoplasty in correlation with spinal metastasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5137/1019-5149.JTN.29550-20.2DOI Listing

OCCULT PRIMARY HYPERPARATHYROIDISM: A CASE REPORT AND REVIEW OF PARATHYROID ULTRASONOGRAPHY.

AACE Clin Case Rep 2020 May-Jun;6(3):e127-e131. Epub 2020 May 11.

Objective: To discuss the diagnosis and management of occult primary hyperparathyroidism.

Methods: We present the biochemical and radiologic evaluation, treatment, and outcome of a woman with occult primary hyperparathyroidism which presented as an unusual neck mass on ultrasound. We also present a relevant literature review. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4158/ACCR-2019-0523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282275PMC

Managing common endocrine disorders amid COVID-19 pandemic.

Diabetes Metab Syndr 2020 Jun 4;14(5):767-771. Epub 2020 Jun 4.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. Electronic address:

Background And Aims: The novel coronavirus disease (COVID-19) pandemic and the resulting nationwide lockdowns have posed a major challenge to the management of pre-existing and newly diagnosed endocrine disorders. Herein, we have summarized the management approaches of common endocrine disorders amid the ongoing pandemic.

Methods: We have performed an extensive literature search for articles in PubMed, EMBASE and Google Scholar databases till 25 May 2020, with the following keywords: "COVID-19", "diabetes mellitus", "thyroid disorders", "primary adrenal insufficiency", "Cushing's syndrome", "pituitary tumors", "vitamin D″", "osteoporosis", "primary hyperparathyroidism", "hypoparathyroidism", "management", "treatment" and "guidelines" with interposition of the Boolean operator "AND". Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dsx.2020.05.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271862PMC

Association of Bariatric Surgery With Risk of Fracture in Patients With Severe Obesity.

JAMA Netw Open 2020 Jun 1;3(6):e207419. Epub 2020 Jun 1.

Department of Surgery, Rush University Medical Center, Chicago, Illinois.

Importance: Given the complex relationship between body mass index, body composition, and bone density and the correlative nature of the studies that have established the prevailing notion that higher body mass indices may be protective against osteopenia and osteoporosis and, therefore, fracture, the absolute risk of fracture in patients with severe obesity who undergo either Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) compared with those who do not undergo bariatric surgery is unknown.

Objective: To assess the rates of fractures associated with obesity and compare rates between those who do not undergo bariatric surgery, those who undergo RYGB, and those who undergo SG.

Design, Setting, And Participants: In this retrospective multicenter cohort study of Medicare Standard Analytic Files derived from Medicare parts A and B records from January 2004 to December 2014, patients classified as eligible for bariatric surgery using the US Centers of Medicare & Medicaid criteria who either did not undergo bariatric surgery or underwent RYGB or SG were exactly matched in a 1:1 fashion based on their age, sex, Elixhauser Comorbidity Index, hypertension, smoking status, nonalcoholic fatty liver disease, hyperlipidemia, type 2 diabetes, osteoporosis, osteoarthritis, and obstructive sleep apnea status. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamanetworkopen.2020.7419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287567PMC

Radiculopathy Following Vertebral Body Compression Fracture: The Role of Percutaneous Cement Augmentation.

Pain Physician 2020 Jun;23(3):315-324

University of Colorado, Aurora, Colorado.

Background: Vertebral cement augmentation is a commonly used procedure in patients with vertebral body compression fractures from primary or secondary osteoporosis, metastatic disease, or trauma. Many of these patients present with radiculopathy as a presenting symptom, and can experience symptomatic relief following the procedure.

Objectives: To determine the incidence of preprocedural radiculopathy in patients with vertebral body compression fractures presenting for cement augmentation, and present their postoperative outcomes. Read More

View Article

Download full-text PDF

Source