89,274 results match your criteria Osteoporosis


Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu-gu-zhi) and its potential inhibition against human cytochrome P450s and UDP-glucuronosyltransferases.

J Pharm Pharmacol 2020 Aug 4. Epub 2020 Aug 4.

Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, China.

Objectives: Isobavachin is a phenolic with anti-osteoporosis activity. This study aimed to explore its metabolic fates in vivo and in vitro, and to investigate the potential drug-drug interactions involving CYPs and UGTs.

Methods: Metabolites of isobavachin in mice were first identified and characterized. Read More

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http://dx.doi.org/10.1111/jphp.13337DOI Listing

Efficacy of Postural Reduction of Vertebral Compression Fracture with Extension Lateral Radiograph Prior to Vertebroplasty.

World Neurosurg 2020 Aug 1. Epub 2020 Aug 1.

Department of Orthopedic Surgery, Dongguk University Ilsan Hospital, Goyangsi, Gyeonggido, Republic of Korea. Electronic address:

Objective: This retrospective comparative study aimed to evaluate the efficacy of postural reduction of vertebral compression fracture (VCF) using the hyperextension posture prior to vertebroplasty (VP) METHODS: Sixty-five consecutive patients who underwent VP were retrospectively reviewed. Thirty patients who underwent passive expansion of compression fracture prior to VP (postural reduction vertebroplasty [PRV] group) were compared with 35 patients who underwent in situ vertebroplasty (ISV group). Patient characteristics, complications, local kyphosis angle (LKA), Cobb's angle (CA), sagittal index (SI), anterior body height (ABH), and posterior body height (PBH) were assessed. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.07.188DOI Listing

Germinated black soybean fermented with Lactobacillus pentosus SC65 alleviates DNFB-induced delayed-type hypersensitivity in C57BL/6N mice.

J Ethnopharmacol 2020 Aug 1:113236. Epub 2020 Aug 1.

Department of Food Science and Biotechnology, College of BioNano, Gachon University, 1342 Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, 461-701, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: Rhynchosia nulubilis (black soybean) has many applications in oriental medicine. It is traditionally used to treat disease related with high blood pressure, diabetes, inflammation, and osteoporosis. Furthermore, fermented soybean foods have traditionally been used for immunity enhancement in East Asia. Read More

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http://dx.doi.org/10.1016/j.jep.2020.113236DOI Listing

Comparison of vertebral and femoral strength between Caucasian and Asian adults using finite element analysis of computed tomography scans.

J Bone Miner Res 2020 Aug 4. Epub 2020 Aug 4.

Department of Internal Medicine, Endocrine Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Given non-optimal testing rates for DXA, and the high use of CT in some Asian countries, biomechanical computed tomography analysis (BCT)-based bone strength testing, which utilizes previously taken clinical CT scans, may improve osteoporosis testing rates. However, an understanding of ethnic differences in such bone strength measurements between Caucasians and Asians is lacking, which is an obstacle to clinical interpretation. Using previously taken CT and DXA scans, we analyzed bone strength and BMD at the hip and spine in two sex- and age-matched community-based cohorts, aged 40 to 80 years: Caucasians (Rochester, MN, USA) and Koreans (Seoul, South Korea). Read More

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http://dx.doi.org/10.1002/jbmr.4149DOI Listing

Bilirubin and bile acids in osteocytes and bone tissue.Potential role in the cholestatic-induced osteoporosis.

Liver Int 2020 Aug 4. Epub 2020 Aug 4.

Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Spain.

Background And Aims: Osteoporosis is a common complication in patients with primary biliary cholangitis. Both bilirubin and lithocholic acid (LCA) result in detrimental effects on osteoblastic cells, and ursodeoxycholic acid (UDCA) counteracts these outcomes. However, there is no information on the consequences of these retained substances of cholestasis and sera from cholestatic patients in osteocytes. Read More

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http://dx.doi.org/10.1111/liv.14630DOI Listing

Clinical Utility of Computer-aided Diagnosis of Vertebral Fractures from Computed Tomography (CT) Images.

J Bone Miner Res 2020 Aug 4. Epub 2020 Aug 4.

St Vincent's Hospital, Darlinghurst, New South Wales, Australia.

Osteoporotic vertebral compression fractures (VCF) are a risk factor for morbidity and mortality, frequently asymptomatic and often present in Computed Tomography (CT) scans performed for unrelated conditions. Computer-aided diagnosis (CAD) of VCF from such images can potentially improve identification and treatment of osteoporosis. This single-blinded, single tertiary centre study compared a CAD (Zebra Medical Vision®) to an adjudicated imaging specialist re-evaluation using a retrospective consecutive sample of abdominal and thoracic CT scans (n = 2357) performed as part of routine care. Read More

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http://dx.doi.org/10.1002/jbmr.4146DOI Listing

Simple and fast diagnosis of osteoporosis based on UV-visible hair fluorescence spectroscopy.

Appl Opt 2020 Aug;59(22):6774-6780

The aim of this work is to propose a new analytical technique based on UV-visible fluorescence as an alternative to x-ray absorptiometry for diagnosing osteoporosis, as well as its early stage by identifying osteopenia. The equipment used consists of very cheap equipment compared to x-ray scanners with an LED as the excitation source. In this work, we analyzed 90 hair samples taken from volunteers of different ages at Habib Thameur Hospital in Tunis. Read More

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http://dx.doi.org/10.1364/AO.393646DOI Listing

Effects of Simulated Microgravity on Muscle Stem Cells Activity.

Cell Physiol Biochem 2020 Aug;54(4):736-747

Center of Space BioMedicine, "Tor Vergata" University of Rome, Rome, Italy.

Background/aims: The study of the effects of simulated microgravity on primary cultures of human satellite cells represents a reliable model for identifying the biomolecular processes involved in mechanic load-related muscle mass loss. Therefore, this study aims to investigate the role of myostatin and Bone Morphogenetic Protein-2 in human satellite cells response to simulated microgravity condition.

Methods: In order to identify the main molecules involved in the phenomena of degeneration/regeneration of muscle tissue related to the alteration of mechanic load, we performed a morphological and immunohistochemical study on 27 muscle biopsies taken from control, osteoporotic and osteoarthritic patients, underwent hip arthroplasty. Read More

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http://dx.doi.org/10.33594/000000252DOI Listing

Aggregation of Region-based and Boundary-based Knowledge biased Segmentation for Osteoporosis Detection from X-Ray, Dual X-Ray and CT Images.

Curr Med Imaging 2020 Jul 30. Epub 2020 Jul 30.

Chennai Institute of Technology, Chennai, Tamil Nadu. India.

Background: Osteoporosis is a term used to represent the reduced bone density which is caused by insufficient bone tissue production to balance the old bone tissue removal. Medical Imaging procedures such as X-Ray, Dual X-Ray and Computed Tomography (CT) scans are used widely in osteoporosis diagnosis. There are several existing procedures are in practice to assist osteoporosis diagnosis which can operate using a single imaging method. Read More

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http://dx.doi.org/10.2174/1573405616999200730175526DOI Listing

The Effects of NPY1 Receptor Antagonism on Intervertebral Disc and Bone Changes in Ovariectomized Rats.

Global Spine J 2020 Aug 4:2192568220939908. Epub 2020 Aug 4.

University of Mississippi Medical Center, Jackson, MS, US.

Study Design: Basic science.

Objective: To compare the effects of a neuropeptide Y1 receptor antagonist (NPY-1RA) to estrogen on maintaining vertebral bone microarchitecture and disc height in a rat model of menopause.

Methods: This study was an institutional animal care approved randomized control study with 104 ovariectomized rats and 32 intact control animals. Read More

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http://dx.doi.org/10.1177/2192568220939908DOI Listing

A Systematic Review of Treatment Strategies for the Prevention of Junctional Complications After Long-Segment Fusions in the Osteoporotic Spine.

Global Spine J 2020 Aug 4:2192568220939902. Epub 2020 Aug 4.

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Study Design: Systematic review.

Objectives: Proximal junctional kyphosis (PJK) and proximal junctional failure (PJF) are well-known complications after long-segment fusions in the thoracolumbar spine of osteoporotic patients. Recent advances in anti-resorptive and anabolic medications, instrumentation, surgical technique, and cement augmentation have all aided in the avoidance of junctional kyphosis. Read More

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http://dx.doi.org/10.1177/2192568220939902DOI Listing

Bone mineral density spectrum in individuals with type 1 diabetes, LADA, and type 2 diabetes.

Diabetes Metab Res Rev 2020 Aug 3:e3390. Epub 2020 Aug 3.

Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Objective: To assess bone mineral density (BMD) and associated clinical factors in patients with type 1 diabetes (T1D), latent autoimmune diabetes in adults (LADA), and type 2 diabetes (T2D) and in non-diabetic subjects.

Methods: Total 108 age-, sex-, disease duration- and postmenopausal ratio-matched patients with T1D, LADA and T2D each and 216 age-, sex- and postmenopausal ratio-matched non-diabetic controls. Anthropometric, biochemical and BMD data were collected and analysed. Read More

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http://dx.doi.org/10.1002/dmrr.3390DOI Listing

Fracture risk assessment in celiac disease: a registry-based cohort study.

Osteoporos Int 2020 Aug 3. Epub 2020 Aug 3.

University of Manitoba, Winnipeg, Canada.

Celiac disease is associated with an increased fracture risk but is not a direct input to the FRAX® calculation. When celiac disease is considered as a secondary osteoporosis risk factor or BMD is included in the FRAX assessment, FRAX accurately predicts fracture risk.

Introduction: The fracture risk assessment tool (FRAX®) uses clinical factors and bone mineral density (BMD) measurement to predict 10-year major osteoporotic (MOF) fracture probability. Read More

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http://dx.doi.org/10.1007/s00198-020-05579-7DOI Listing

Bone density and strength from thoracic and lumbar CT scans both predict incident vertebral fractures independently of fracture location.

Osteoporos Int 2020 Aug 3. Epub 2020 Aug 3.

Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, RN115, 330 Brookline Avenue, Boston, MA, 02215, USA.

In a population-based study, we found that computed tomography (CT)-based bone density and strength measures from the thoracic spine predicted new vertebral fracture as well as measures from the lumbar spine, suggesting that CT scans at either the thorax or abdominal regions are useful to assess vertebral fracture risk.

Introduction: Prior studies have shown that computed tomography (CT)-based lumbar bone density and strength measurements predict incident vertebral fracture. This study investigated whether CT-based bone density and strength measurements from the thoracic spine predict incident vertebral fracture and compared the performance of thoracic and lumbar bone measurements to predict incident vertebral fracture. Read More

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http://dx.doi.org/10.1007/s00198-020-05528-4DOI Listing

Predictors of imminent risk of fracture in Medicare-enrolled men and women.

Arch Osteoporos 2020 Aug 3;15(1):120. Epub 2020 Aug 3.

Amgen Inc., Thousand Oaks, CA, USA.

Advancing age, female sex, recent prior fracture and falls, and specific comorbidities and medications contribute to imminent (within 1-2 years) risk of fracture in Medicare enrollees. Clinician awareness of these risk factors and their dynamic nature may lead to improved osteoporosis care for elderly patients.

Purpose: The burden of osteoporotic fracture disproportionately affects the elderly. Read More

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http://dx.doi.org/10.1007/s11657-020-00784-7DOI Listing

Risk factors of skeletal-related events in patients with bone metastasis from non-small cell lung cancer undergoing treatment with zoledronate-a post hoc analysis of a randomized clinical trial.

Support Care Cancer 2020 Aug 3. Epub 2020 Aug 3.

Division of Hematology and Medical Oncology, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: Skeletal-related events (SREs) are critical events for patients with bone metastasis from non-small cell lung cancer (NSCLC). Thus, bone-modifying agents are recommended in this population. However, the baseline risk factors of SREs in patients with bone metastasis from NSCLC are not well established. Read More

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http://dx.doi.org/10.1007/s00520-020-05665-wDOI Listing

The Belgian Bone Club 2020 guidelines for the management of osteoporosis in postmenopausal women.

Maturitas 2020 Sep 16;139:69-89. Epub 2020 May 16.

WHO Collaborating Center for Public Health aspects of musculo-skeletal health and ageing, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.

Purpose: To provide updated evidence-based guidelines for the management of osteoporosis in postmenopausal women in Belgium.

Methods: The Belgian Bone Club (BBC) gathered a guideline developer group. Nine "Population, Intervention, Comparator, Outcome" (PICO) questions covering screening, diagnosis, non-pharmacological and pharmacological treatments, and monitoring were formulated. Read More

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http://dx.doi.org/10.1016/j.maturitas.2020.05.006DOI Listing
September 2020

Evaluation of the bone morphology around four types of porous metal implants placed in distal femur of ovariectomized rats.

J Orthop Surg Res 2020 Aug 3;15(1):296. Epub 2020 Aug 3.

NYU Langone Medical Center, Hospital for Joint Diseases, New York, USA.

Background: To compare structural features of the femoral bone of ovariectomized and non-ovariectomized rats after implantation of porous materials (TANTALUM, CONCELOC, TTM, ATLANT).

Methods: Experiments were carried out on 56 white laboratory female rats aged 6 months. Rats were randomly assigned into groups: sham-operated control group (SH) or ovariectomy group (OVX). Read More

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http://dx.doi.org/10.1186/s13018-020-01822-3DOI Listing

Current Status of Sarcopenia in Korea: A Focus on Korean Geripausal Women.

Authors:
Hyoung Moo Park

Ann Geriatr Med Res 2018 Jun 30;22(2):52-61. Epub 2018 Jun 30.

Menopause Clinic, Grace Women's Hostpital, Goyang, Korea.

Sarcopenia is defined as an age-associated decline in muscle mass and function caused by several etiologies and mechanisms. Muscle mass and function do not decrease concurrently, and a loss of muscle function may be more highly associated with adverse health outcomes. Despite the clinical significance of sarcopenia, no universally operational definition of sarcopenia or standardized intervention programs are currently available. Read More

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http://dx.doi.org/10.4235/agmr.2018.22.2.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387617PMC

Validity of self-reported cancer: Comparison between self-report versus cancer registry records in the Geelong Osteoporosis Study.

Cancer Epidemiol 2020 Jul 31;68:101790. Epub 2020 Jul 31.

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, Barwon Health, Geelong, Australia. Electronic address:

Background: Determining the validity of self-reported data is important. The aim of this study was to assess the validity of self-reported cancer and investigate factors associated with accurate reporting in men and women.

Methods: Study participants (n = 1727) from the Geelong Osteoporosis Study, located in south-eastern Australia, were utilised. Read More

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http://dx.doi.org/10.1016/j.canep.2020.101790DOI Listing

Preoperative hypoalbuminemia: Poor functional outcomes and quality of life after hip fracture surgery.

Bone 2020 Jul 31:115567. Epub 2020 Jul 31.

Singapore General Hospital, Outram Rd, Singapore 169608.

Aims: Hip fracture patients have severe deterioration of their quality of life and function after their injury. Markers of malnutrition such as low albumin and low body mass index (BMI) have been shown to increase mortality and complication rates but their effect on recovery of quality of life and function after hip fracture surgery is unclear. The main aim of this paper is to further investigate if low albumin affects recovery after hip fracture surgery, while additionally studying low BMI as a possible risk factor for poor recovery. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115567DOI Listing

Bisphosphonates and lifespan.

Bone 2020 Jul 31:115566. Epub 2020 Jul 31.

Bone Biology, Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Hospital Clinical School, Faculty of Medicine, UNSW, Sydney, Australia.

Bisphosphonates are first line agents used to treat osteoporosis and reduce fracture rate. They bind to areas of exposed calcium in the skeleton and cause osteoclast apoptosis, thereby leading to a reduction in remodelling rates. They are also used to decrease skeletal complications of some cancers including a reduction in bone metastases. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115566DOI Listing

Improved Outcomes Using a Fibular Strut in Proximal Humerus Fracture Fixation.

Orthopedics 2020 Aug 3:1-7. Epub 2020 Aug 3.

Proximal humerus fractures, although common, have high rates of failure after open reduction and internal fixation. The use of a fibular allograft has been explored as a means to decrease complications, particularly varus collapse and the need for revision surgery. The authors performed a retrospective review of 133 proximal humerus fractures managed surgically with locking plates (n=72) or locking plates with fibular allograft intramedullary struts (n=61). Read More

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http://dx.doi.org/10.3928/01477447-20200721-02DOI Listing

Impact of physical activity, anthropometric, body composition and dietary factors on bone stiffness in German university students.

J Sports Med Phys Fitness 2020 Jul 30. Epub 2020 Jul 30.

Institute of Health Sciences, University of Education Schwäbisch Gmünd, Schwäbisch Gmünd, Germany.

Background: Bone density in the young-adult life is associated with risk for osteoporosis in later life. Next to genetic factors, lifestyle seems to play an important role for bone health. Purpose of the study was to clarify the relationship between various lifestyle factors and bone parameters in university students. Read More

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http://dx.doi.org/10.23736/S0022-4707.20.11281-7DOI Listing

Clinical research linking Traditional Chinese Medicine constitution types with diseases: a literature review of 1639 observational studies.

J Tradit Chin Med 2020 Aug;40(4):690-702

Center for Studies in Constitution Research and Reproductive Sciences of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.

Objective: To analyze clinical studies on correlations between Traditional Chinese Medicine (TCM) body constitution types and diseases published in the past 10 years, and to provide an evidence base to support the use of such correlations for health maintenance and disease prevention.

Methods: We searched five databases for the period April 2009 to December 2019: China National Knowledge Infrastructure Database, Wanfang Database, China Science and Technology Journal Database, PubMed and Embase. Three types of observational studies on correlation between constitution types and diseases were included: cross-sectional, case-control and cohort studies. Read More

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http://dx.doi.org/10.19852/j.cnki.jtcm.2020.04.019DOI Listing

The value of bioactive compounds of cruciferous vegetables (Brassica) as antimicrobials and antioxidants: A review.

J Food Biochem 2020 Aug 3:e13414. Epub 2020 Aug 3.

Graduate Program in Biochemical Engineering, Biological Sciences Faculty, Autonomous University of Coahuila, Torreón, México.

Nowadays, consumers are demanding nutrient-rich products for health optimal benefits. In this regard, Brassicaceae family plants, previously named cruciferous, group a large number of widely consumed species around the world. The popularity of Brassica is increasing due to their nutritional value and pharmacological effects. Read More

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http://dx.doi.org/10.1111/jfbc.13414DOI Listing

Establishment of a non-human primate model for menopausal hot flushes.

EC Gynaecol 2020 Jan 11;9(1). Epub 2019 Dec 11.

Oregon National Primate Research Center, Oregon Health and Science University.

Menopause affects the quality of life of millions of women. With modern lifespan the postmenopausal attenuation of circulating estrogen levels can negatively impact a women's life for 30-40 years. The major hypoestrogenic consequence is hot flushes but decline in cognitive function, sleep disorders, depression/anxiety, cardiovascular disease, and osteoporosis are also characteristic for the menopause. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394307PMC
January 2020

Management Challenges in Atypical Femoral Fractures: A Case Report.

Ann Geriatr Med Res 2020 Mar 24;24(1):50-54. Epub 2020 Mar 24.

School of Medicine, University of Western Australia, Crawley, Perth, Australia.

A 78-year-old woman presented with an atypical femoral fracture of her right femur associated with a left thigh stress fracture following 9 years of bisphosphonate therapy. The fracture was managed with femoral nailing. However, she represented 3 years later with peri-prosthetic infection, worsening of the left-side stress fracture, and low bone turnover in a bone metabolic study, consistent with an ongoing bisphosphonate effect. Read More

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http://dx.doi.org/10.4235/agmr.19.0046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370781PMC

Femoral Intertrochanteric Fractures of the Patients in the Emergency Department due to Minor Falls: Special Consideration in the Middle-old to Oldest-old Patients.

Ann Geriatr Med Res 2019 Sep 27;23(3):125-132. Epub 2019 Sep 27.

Department of Emergency Medicine, Kyung Hee University Hospital, Seoul, Korea.

Background: The older population (≥65 years) has rapidly increased in size in recent years. Among them, the middle-to-oldest-old (≥75 years) tend to have a poor health status. Therefore, subdivision and evaluation of older patients with traumatic injury are required. Read More

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http://dx.doi.org/10.4235/agmr.19.0027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370770PMC
September 2019

Evaluation of bone densitometry by dual-energy x-ray absorptiometry as a fracture prediction tool in women with chronic kidney disease.

Bone Rep 2020 Dec 18;13:100298. Epub 2020 Jul 18.

Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Background: The 2017 KDIGO guidelines establish a 2B grade recommendation in favor of testing Bone Mineral Density (BMD) by DXA to assess osteoporotic fracture (OPF) risk in patients with CKD G3a-G5D. Still, controversy remains because large studies evaluating it for this particular population are lacking.

Aim: To establish the clinical performance of BMD measured by DXA in the evaluation of fracture risk in women with CKD. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387779PMC
December 2020

Body composition with dual energy X-ray absorptiometry: from basics to new tools.

Quant Imaging Med Surg 2020 Aug;10(8):1687-1698

IRCCS Istituto Ortopedico Galeazzi, Via Riccardo Galeazzi 4, 20161 Milano, Italy.

Dual-energy X-ray absorptiometry (DXA) in nowadays considered one of the most versatile imaging techniques for the evaluation of metabolic bone disorders such as osteoporosis, sarcopenia and obesity. The advantages of DXA over other imaging techniques are the very low radiation dose, its accuracy and simplicity of use. In addition, fat mass (FM) and lean mass (LM) values by DXA shows very good accuracy compared to that of computed tomography and magnetic resonance imaging. Read More

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http://dx.doi.org/10.21037/qims.2020.03.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378094PMC

Fat and bone: the multiperspective analysis of a close relationship.

Quant Imaging Med Surg 2020 Aug;10(8):1614-1635

Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

The study of bone has for many years been focused on the study of its mineralized component, and one of the main objects of study as radiology developed as a medical specialty. The assessment has until recently been almost limited to its role as principal component of the scaffolding of the human body. Bone is a very active tissue, in continuous cross-talk with other organs and systems, with functions that are endocrine and paracrine and that have an important involvement in metabolism, ageing and health in general. Read More

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http://dx.doi.org/10.21037/qims.2020.01.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378091PMC

The Impact of "Vaping" Electronic Cigarettes on Spine Health.

Cureus 2020 Jun 29;12(6):e8907. Epub 2020 Jun 29.

Molecular and Integrative Physiology, University of Michigan, Ann Arbor, USA.

"Vaping" or the use of electronic cigarettes (e-cigarettes) has greatly increased within the past decade, with growing popularity among adolescents. E-cigarettes have many harmful effects on multiple organ systems, but more research is needed to fully understand the extent of possible risks. Our narrative literature review aims to provide comprehensive insight into the impact of e-cigarette use on spinal health with a specific focus on intervertebral disc (IVD) health, bone health, and spinal fusion. Read More

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http://dx.doi.org/10.7759/cureus.8907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389958PMC

Contribution of common chronic conditions to midlife physical function decline: The Study of Women's Health Across the Nation.

Womens Midlife Health 2020 28;6. Epub 2020 Jul 28.

Department of Preventive Medicine, Rush University Medical Center, Chicago, IL USA.

Background: Chronic conditions are associated with worse physical function and commonly develop during midlife. We tested whether the presence of 8 chronic conditions, or the development of these conditions, is associated with declines in physical function among midlife women as they transition into early late life.

Methods: Participants ( = 2283) were from the Study of Women's Health Across the Nation. Read More

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http://dx.doi.org/10.1186/s40695-020-00053-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385881PMC

Acute unilateral anterior uveitis following zoledronic acid infusion: A case report.

SAGE Open Med Case Rep 2020 20;8:2050313X20944305. Epub 2020 Jul 20.

University Medical Unit, Teaching Hospital, Jaffna, Sri Lanka.

Bisphosphonates are widely used to treat several clinical conditions. Zoledronic acid is one of this class, commonly used for the treatment and prevention of osteoporosis, hypercalcemia of malignancy, Paget's disease, and multiple myeloma. A variety of ocular side effects associated with bisphosphonates therapy has been reported but are uncommon and readily treatable. Read More

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http://dx.doi.org/10.1177/2050313X20944305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375717PMC

miR-205 regulates bone turnover in elderly female patients with type 2 diabetes mellitus through targeted inhibition of Runx2.

Exp Ther Med 2020 Aug 10;20(2):1557-1565. Epub 2020 Jun 10.

Department of Endocrinology (I), The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161099, P.R. China.

The present study aimed to explore the expression of microribonucleic acid (microRNA) (miR)-205 in bone tissues and serum of elderly female patients with type 2 diabetes mellitus (T2DM) complicated with osteoporosis (OP), and to investigate the effect of miR-205 on osteogenesis/adipogenesis of bone marrow mesenchymal stem cells (BMSCs) and its mechanism in elderly female mice with T2DM + OP. The bone tissues and serum of 24 female patients with T2DM + OP at the Third Affiliated Hospital of Qiqihar Medical University were collected as the research group, while those of 24 healthy people were collected as the control group. The expression level of miR-205 was detected in both groups via reverse transcription-polymerase chain reaction (RT-PCR). Read More

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http://dx.doi.org/10.3892/etm.2020.8867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388399PMC

Investigation of long non-coding RNA expression profiles in patients with post-menopausal osteoporosis by RNA sequencing.

Authors:
Shaohai Wang

Exp Ther Med 2020 Aug 11;20(2):1487-1497. Epub 2020 Jun 11.

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430012, P.R. China.

The present study aimed to investigate the implication of long non-coding RNA (lncRNA) expression profiles in post-menopausal osteoporosis (PMOP). A total of 10 patients with PMOP and 10 age-matched healthy post-menopausal females as controls were consecutively enrolled. Their peripheral blood mononuclear cells were obtained and lncRNA as well as mRNA expression profiles were detected by RNA sequencing, followed by bioinformatics analyses. Read More

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http://dx.doi.org/10.3892/etm.2020.8881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388310PMC

Description of Normative Spine TBS Data for Men and Women in Mexican Population.

J Clin Densitom 2020 Jul 2. Epub 2020 Jul 2.

Clinical Epidemiology Unit, Hospital Infantil de México Federico Gómez-Facultad de Medicina UNAM, Mexico City, Mexico; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico. Electronic address:

Trabecular Bone Score (TBS) has proven its usefulness to improve areal Bone Mineral Density in diagnosing fracture risk and bone status evaluation. For it to be better interpreted, local reference values are recommended to account for population differences and, if possible, both in women and men, the former being scarcer. Using TBS, we reanalyzed data obtained from the Mexican population included in the Latin American Vertebral Osteoporosis Study and the Mexican Vertebral Study in men that included a random probability sample of 408 women and 414 men aged 50 and older without fractures. Read More

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http://dx.doi.org/10.1016/j.jocd.2020.06.003DOI Listing

Osteoporosis is a Predictive Factor for Nephrolithiasis in an Adult Free-Living Caucasian Population From Southern Italy: A Longitudinal Retrospective Study Based on a General Practice Database.

Calcif Tissue Int 2020 Aug 1. Epub 2020 Aug 1.

Department of Clinical Medicine and Surgery, Federico II University, Via Sergio Pansini 5, 80131, Naples, Italy.

Osteoporosis and nephrolithiasis are common multifactorial disorders with high incidence and prevalence in the adult population worldwide. Both are associated with high morbidity and mortality if not correctly diagnosed and accurately treated. Nephrolithiasis is considered a risk factor for reduced bone mineral density. Read More

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http://dx.doi.org/10.1007/s00223-020-00737-9DOI Listing

Dietary Inflammatory Index in relation to bone mineral density, osteoporosis risk and fracture risk: a systematic review and meta-analysis.

Osteoporos Int 2020 Aug 1. Epub 2020 Aug 1.

School of Public Health, Hangzhou Medical College, 481 Binwen Road, Binjiang District, Hangzhou, 310053, China.

Our systematic review and meta-analysis indicated that pro-inflammatory diets, as measured by higher Dietary Inflammatory Index scores, are significantly associated with lower BMD of lumbar spine and total hip as well as elevated risk of osteoporosis and fractures. These findings may contribute to the development of public health strategies.

Introduction: Inflammatory Index (DII) is a method to assess the inflammatory potential of diets; it has been reported to be associated with several diseases. Read More

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http://dx.doi.org/10.1007/s00198-020-05578-8DOI Listing

Periodontal status and bone metabolism in women in reproductive and postmenopausal periods.

Horm Mol Biol Clin Investig 2020 Aug 3. Epub 2020 Aug 3.

Department of Organization, Management and Economics of Pharmacy and Clinical Pharmacy, Asfendiyarov Kazakh National Medical University, 94 Tole Bi Str., Almaty, 050000,Kazakhstan.

Objectives Chronic periodontitis is one of the most common diseases in the world. Periodontitis occurs more frequently in postmenopausal women due to hormonal changes and in patients with osteoporosis. Thus, the aim of our study was to compare levels of alveolar bone loss of mandible and maxilla and bone tissue remodeling markers in women of reproductive and postmenopausal periods. Read More

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http://dx.doi.org/10.1515/hmbci-2020-0011DOI Listing

The effect of IL-1R1 and IL-1RN polymorphisms on osteoporosis predisposition in a Chinese Han population.

Int Immunopharmacol 2020 Jul 30;87:106833. Epub 2020 Jul 30.

Department of Orthopaedics, Shangqiu First People's Hospital, Shangqiu Clinical College, Xuzhou Medical University, Shangqiu 476100, Henan, China. Electronic address:

Background: Osteoporosis (OP) is a common inflammatory disease. The goal of this study was to investigate the effect of IL-1R1 and IL-1RN polymorphisms on OP predisposition among the Chinese Han population.

Methods: Six single nucleotide polymorphisms (SNPs) in IL-1R1 and IL-1RN were genotyped using the Agena MassARRAY platform in 594 OP patients and 599 age- and sex- matched healthy controls. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106833DOI Listing

Promoting Osteoporosis Best Practices: A New Electronic Medical Record Tool.

J Am Med Dir Assoc 2020 Jul 29. Epub 2020 Jul 29.

GERAS Centre for Aging Research, Hamilton, ON, Canada; McMaster University, Hamilton, ON, Canada.

Despite the high prevalence and devastating outcomes associated with osteoporotic fractures, they are not well investigated or treated. We developed an electronic Osteoporosis and Falls Assessment Form for integration within electronic medical records (EMR) with the aim to improve osteoporosis-related care in family practice. We examined usage and collected usability feedback from 37 physicians. Read More

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http://dx.doi.org/10.1016/j.jamda.2020.06.023DOI Listing

Lumbar disc height and vertebral Hounsfield units: association with interbody cage subsidence.

Neurosurg Focus 2020 Aug;49(2):E9

Objective: Postoperative subsidence of transforaminal lumbar interbody fusion (TLIF) cages can result in loss of lordosis and foraminal height, and potential recurrence of nerve root impingement. The objectives of this study were to determine factors associated with TLIF cage subsidence. Specifically, the authors sought to determine if preoperative disc height compared to cage height could be used to predict TLIF interbody cage subsidence, and if decreased postoperative vertebral Hounsfield units (HUs) predisposed to cage subsidence. Read More

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http://dx.doi.org/10.3171/2020.4.FOCUS20286DOI Listing

Association of osteopenia and osteoporosis with higher rates of pseudarthrosis and revision surgery in adult patients undergoing single-level lumbar fusion.

Neurosurg Focus 2020 Aug;49(2):E6

4Department of Neurosurgery, University of Texas Southwestern Medical School, Dallas, Texas.

Objective: Patients with osteopenia or osteoporosis who require surgery for symptomatic degenerative spondylolisthesis may have higher rates of postoperative pseudarthrosis and need for revision surgery than patients with normal bone mineral densities (BMDs). To this end, the authors compared rates of postoperative pseudarthrosis and need for revision surgery following single-level lumbar fusion in patients with normal BMD with those in patients with osteopenia or osteoporosis. The secondary outcome was to investigate the effects of pretreatment with medications that prevent bone loss (e. Read More

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http://dx.doi.org/10.3171/2020.5.FOCUS20289DOI Listing

Preoperative bone health assessment and optimization in spine surgery.

Neurosurg Focus 2020 Aug;49(2):E2

2University of Wisconsin School of Medicine and Public Health, Osteoporosis Clinical Research Program, Madison, Wisconsin.

Objective: The purpose of this investigation was to characterize the bone health in preoperative spine surgery patients. This information will provide a framework to understand the needs and methods for providing bone health optimization in elective spine surgery patients.

Methods: A retrospective study of 104 patients undergoing bone health optimization was performed. Read More

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http://dx.doi.org/10.3171/2020.5.FOCUS20255DOI Listing

Prevalence of osteoporosis and osteopenia diagnosed using quantitative CT in 296 consecutive lumbar fusion patients.

Neurosurg Focus 2020 Aug;49(2):E5

2Spine Care Institute and.

Objective: Osteoporosis is a metabolic bone disease that increases the risk for fragility fractures. Screening and diagnosis can be achieved by measuring bone mineral density (BMD) using quantitative CT tomography (QCT) in the lumbar spine. QCT-derived BMD measurements can be used to diagnose osteopenia or osteoporosis based on American College of Radiology (ACR) thresholds. Read More

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http://dx.doi.org/10.3171/2020.5.FOCUS20241DOI Listing

Osteoporosis in spine surgery patients: what is the best way to diagnose osteoporosis in this population?

Neurosurg Focus 2020 Aug;49(2):E4

2Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.

Objective: The goal of this study was to compare different recognized definitions of osteoporosis in patients with degenerative lumbar spine pathology undergoing elective spinal fusion surgery to determine which patient population should be considered for preoperative optimization.

Methods: A retrospective review of patients in whom lumbar spine surgery was planned at 2 academic medical centers was performed, and the rate of osteoporosis was compared based on different recognized definitions. Assessments were made based on dual-energy x-ray absorptiometry (DXA), CT Hounsfield units (HU), trabecular bone score (TBS), and fracture risk assessment tool (FRAX). Read More

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http://dx.doi.org/10.3171/2020.5.FOCUS20277DOI Listing

Introduction. Lumbar spinal osteoporosis.

Neurosurg Focus 2020 Aug;49(2):E1

4Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.3171/2020.5.FOCUS20412DOI Listing