82,237 results match your criteria Osteoporosis


Spot the silent sufferers: A call for clinical diagnostic criteria for solar and nutritional osteomalacia.

J Steroid Biochem Mol Biol 2019 Jan 14. Epub 2019 Jan 14.

Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK; Department of Paediatrics and Adolescent Medicine, Johannes Kepler University, Linz, Austria. Electronic address:

Osteomalacia and rickets result from defective mineralization when the body is deprived of calcium. Globally, the main cause of osteomalacia is a lack of mineral supply for bone modeling and remodeling due to solar vitamin D and/or dietary calcium deficiency. Osteomalacia occurs when existing bone is replaced by unmineralized bone matrix (osteoid) during remodeling in children and adults, or when newly formed bone is not mineralized in time during modeling in children. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2019.01.004DOI Listing
January 2019

Biomechanical and Anatomical Validity of the Short Posterior Arch Screw.

Neurospine 2018 Oct 14. Epub 2018 Oct 14.

Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Objective: This study was conducted to clarify the validity of the short posterior arch screw (S-PAS). S-PAS is inserted only in the pedicle analogue portion of the posterior arch. Compared to conventional C1 lateral mass screws inserted via the posterior arch (via-PAS), the S-PAS screw length is almost half that of via-PAS. Read More

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http://dx.doi.org/10.14245/ns.1836156.078DOI Listing
October 2018

Negative Allosteric Modulators of Cannabinoid Receptor 2: Protein Modeling, Binding Site Identification and Molecular Dynamics Simulations in the Presence of an Orthosteric Agonist.

J Biomol Struct Dyn 2019 Jan 17:1-23. Epub 2019 Jan 17.

a Department of BioMolecular Sciences, Division of Medicinal Chemistry, School of Pharmacy , The University of Mississippi, University , MS 38677 , USA.

Selective activation of the cannabinoid receptor subtype 2 (CB2) shows promise for treating pain, inflammation, multiple sclerosis, cancer, ischemic/reperfusion injury, and osteoporosis. Target selectivity and off-target side effects are two major limiting factors for orthosteric ligands, and, therefore, the search for allosteric modulators (AMs) is a widely used drug discovery approach. To date, only a limited number of CB2 AMs have been identified, possessing only micromolar activity at best, and the CB2 receptor's allosteric site(s) are not well characterized. Read More

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http://dx.doi.org/10.1080/07391102.2019.1567384DOI Listing
January 2019

Changes in middle ear transmission characteristics secondary to altered bone remodelling.

Osteoporos Int 2019 Jan 16. Epub 2019 Jan 16.

Department of Audiology, All India Institute of Speech and Hearing, Manasagangothri, Mysore, Karnataka, 570006, India.

Alteration in the process of bone remodelling results in conditions like osteopenia and osteoporosis in which the bones become susceptible to fracture. The functioning of middle ear bones in such individuals were assessed in this study and it was found that the middle ear bones are equally susceptible to micro-fractures and can cause reduction in the transmission of sound energy.

Introduction: Alteration in the process of bone remodelling or increase in the number of osteoclasts cells as it occurs in osteoporosis and osteopenia are likely to affect the middle ear bones in the same way it affects the skeletal bones. Read More

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http://dx.doi.org/10.1007/s00198-019-04834-wDOI Listing
January 2019

Long non-coding RNA XIST promotes osteoporosis through inhibiting bone marrow mesenchymal stem cell differentiation.

Exp Ther Med 2019 Jan 29;17(1):803-811. Epub 2018 Nov 29.

Department of Orthopedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China.

The purpose of the present study was to identify the key long non-coding (lnc)RNAs in the occurrence and development of osteoporosis (OP) and to explore the associated molecular mechanism. First, the Gene Expression Omnibus (GEO) datasets, with key words 'osteoporosis' and 'HG-133A', were screened. RankProd R package was used to calculate the dysregulated lncRNAs in OP. Read More

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http://dx.doi.org/10.3892/etm.2018.7033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307375PMC
January 2019

Expression of microRNA-21 in osteoporotic patients and its involvement in the regulation of osteogenic differentiation.

Exp Ther Med 2019 Jan 21;17(1):709-714. Epub 2018 Nov 21.

Department of Orthopaedics (Ⅱ), The First Hospital of Qiqihar City, Qiqihar, Heilongjiang 161005, P.R. China.

Expression of microRNA-21 in bone tissue and serum of patients with osteoporosis (OP) and its involvement in the regulation of osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMSCs) were investigated. Bone tissue and serum were collected from 48 patients with OP and 48 normal subjects. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression of six microRNAs. Read More

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http://dx.doi.org/10.3892/etm.2018.6998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307376PMC
January 2019

Bone marrow adipose amount influences vertebral bone strength.

Exp Ther Med 2019 Jan 22;17(1):689-694. Epub 2018 Nov 22.

Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

Association of bone marrow adipose and microstructure with bone strength in osteoporotic rats using MR Dixon analysis and micro-CT was evaluated. A total of 40 female Sprague-Dawley rats (6-month-old) were divided randomly into sham-operated (SHAM, n=20) group and ovariectomized (OVX, n=20) group. Fat fraction (FF) was measured by two-point Dixon method with MR imaging at the baseline, 4th, 8th and 12th week, respectively. Read More

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http://dx.doi.org/10.3892/etm.2018.7003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307407PMC
January 2019

Correlation of the severity of chronic kidney disease with serum inflammation, osteoporosis and vitamin D deficiency.

Authors:
Cewen Liu Hui Li

Exp Ther Med 2019 Jan 1;17(1):368-372. Epub 2018 Nov 1.

Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.

Correlation of the severity of chronic kidney disease (CKD) with serum inflammation, osteoporosis and vitamin D deficiency was investigated. A total of 78 patients suffering from CKD who presented to the Union Hospital from December 2015 to December 2017 were selected randomly and divided into three groups based on the severity of the disease. Comparisons of interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), indicators of osteoporosis [serum phosphate, serum calcium and bone mineral density (BMD)], content of 25(OH)D, serum sodium, serum potassium and BUN were conducted among groups. Read More

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http://dx.doi.org/10.3892/etm.2018.6916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307476PMC
January 2019

lncRNA MEG3 is downregulated in ankylosing spondylitis and associated with disease activity, hospitalization time and disease duration.

Exp Ther Med 2019 Jan 2;17(1):291-297. Epub 2018 Nov 2.

Department of Orthopedics, Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, P.R. China.

Long non-coding (lnc)RNA maternally expressed gene 3 (MEG3) has been proved to participate in osteoporosis, which features inverse pathological changes to those associated with spondylosis. The present study aimed to investigate the involvement of lncRNA MEG3 in ankylosing spondylitis. Blood and open sacroiliac joint biopsies were obtained from ankylosing spondylitis patients and healthy controls, and the expression of MEG3 in those tissues was detected by reverse-transcription-quantitative polymerase chain reaction analysis. Read More

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http://dx.doi.org/10.3892/etm.2018.6921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307436PMC
January 2019

Effect of the lipoxygenase inhibitor baicalein on bone tissue and bone healing in ovariectomized rats.

Nutr Metab (Lond) 2019 11;16. Epub 2019 Jan 11.

1Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Goettingen, 37075 Goettingen, Germany.

Background: Osteoporosis is one of the world's major medical burdens in the twenty-first century. Pharmaceutical intervention currently focusses on decelerating bone loss, but phytochemicals such as baicalein, which is a lipoxygenase inhibitor, may rescue bone loss. Studies evaluating the effect of baicalein in vivo are rare. Read More

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http://dx.doi.org/10.1186/s12986-018-0327-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329162PMC
January 2019

Outdoor physical activity bears multiple benefits to health and society.

J Sports Med Phys Fitness 2019 Jan 16. Epub 2019 Jan 16.

School of Exercise Sciences, Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy: 2 IRCSS Istituto Ortopedico Galeazzi, Milan, Italy.

Introduction: Cutting-edge technologies and the rapid urbanization have led to several advantages for mankind and society. However such benefits have been accompanied with the alarming diffusion of sedentary lifestyle disorders, metabolic diseases, major depression and socialization problems, affecting global economy dramatically. The pandemic expansion of chronic diseases is associated with physical inactivity. Read More

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http://dx.doi.org/10.23736/S0022-4707.18.08771-6DOI Listing
January 2019

Pharmacophore-based screening of differentially-expressed , , and from hMSC cell lines reveals five novel therapeutic compounds for primary osteoporosis.

J Genet Eng Biotechnol 2016 Jun 12;14(1):203-210. Epub 2016 Jan 12.

Brearley School, New York, NY 10021, USA.

As many societies age, primary osteoporosis (PO) is increasingly a major health problem. Current drug treatments such as alendronate and risedronate have known side effects. We took an agnostic empirical approach to find PO therapeutic compounds. Read More

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http://dx.doi.org/10.1016/j.jgeb.2015.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299905PMC

Pharmacology of Bisphosphonates.

Br J Clin Pharmacol 2019 Jan 16. Epub 2019 Jan 16.

Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK.

The biological effects of the bisphosphonates (BPs) as inhibitors of calcification and bone resorption were first described in the late 1960s. In the 50 years that have elapsed since then, the BPs have become the leading drugs for the treatment of skeletal disorders characterised by increased bone resorption, including Paget's disease of bone, bone metastases, multiple myeloma, osteoporosis and several childhood inherited disorders. The discovery and development of the BPs as a major class of drugs for the treatment of bone diseases is a paradigm for the successful journey from 'bench to bedside and back again'. Read More

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http://dx.doi.org/10.1111/bcp.13867DOI Listing
January 2019

Fragility Fractures: Diagnosis and Treatment.

Am J Orthop (Belle Mead NJ) 2018 Dec;47(12)

Physicians Regional Hospital, 6101 Pine Ridge Road, Desk 23A, Naples FL 34119, USA. Email:

Fragility fractures are estimated to affect 3 million people annually in the United States. As they are associated with a significant mortality rate, the prevention of these fractures should be a priority for orthopedists. At-risk patients include the elderly and those with thyroid disease, diabetes, hypertension, and heart disease. Read More

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http://dx.doi.org/10.12788/ajo.2018.0112DOI Listing
December 2018

Oviductus Ranae protein hydrolyzate prevents menopausal osteoporosis by regulating TGFβ/BMP2 signaling.

Arch Gynecol Obstet 2019 Jan 16. Epub 2019 Jan 16.

Changchun University of Chinese Medicine, Boshuo Road, No. 1035, Jing Yue Development Zone, Changchun, 130117, China.

Purpose: It is known that menopausal osteoporosis (MOP) is the most typical form of osteoporosis, which is characterized by low bone mass and microstructure damage of the bone tissue, leading to increased bone fragility and risk of fracture. This study aimed to evaluate the protective effects of Oviductus Ranae protein hydrolyzate (ORPH) on the MOP in vivo.

Methods: Osteoporosis model was induced by ovariectomy, treated with ORPH 150 or 75 mg kg. Read More

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http://dx.doi.org/10.1007/s00404-018-5033-9DOI Listing
January 2019

Performance of referral strategies for spondyloarthritis: a population-based nationwide study.

Rheumatology (Oxford) 2019 Jan 14. Epub 2019 Jan 14.

NOVA Medical School, Universidade Nova de Lisboa, Lisboa, Portugal.

Objectives: To evaluate the performance of the referral strategy (RS) for SpA of a nationwide epidemiological study (EpiReumaPt), as compared with previously proposed RSs.

Methods: EpiReumaPt was a three-stage national epidemiologic study. In phase one, 10 661 adult participants were randomly selected and screened for rheumatic and musculoskeletal diseases. Read More

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http://dx.doi.org/10.1093/rheumatology/key436DOI Listing
January 2019

Trichotillomania Triggered by Vitamin D Deficiency and Resolving Dramatically With Vitamin D Therapy.

Authors:
İsmail Akaltun

Clin Neuropharmacol 2019 Jan/Feb;42(1):20-21

Gaziantep Dr. Ersin Arslan Training and Research Hospital, Department of Child and Adolescent Psychiatry, Gaziantep, Turkey.

Trichotillomania (TTM) is a disorder characterized by the individual pulling out his hair in a repetitive manner, resulting in significant hair loss, a feeling of tension before the hair pulling, and pleasure during it. Our understanding of the neurobiological basis of TTM is limited. However, the condition in all likelihood involves multiple pathways and a complex interaction between various genetic, psychological, and social factors. Read More

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http://dx.doi.org/10.1097/WNF.0000000000000317DOI Listing
January 2019

Ankle Osteoarthritis - Arthroplasty or Arthrodesis?

Ortop Traumatol Rehabil 2018 Oct;20(5):361-370

Samodzielny Publiczny Wojewódzki Szpital Chirurgii Urazowej im. Dra Janusza Daaba w Piekarach Śląskich, Polska / District Hospital of Orthopaedics and Trauma Surgery in Piekary Śląskie, Poland.

Osteoarthritis of the talocrural joint accounts for only 4% of cases of degenerative disease of the musculo-skeletal system. Unlike other joints, idiopathic OA of the ankle joint is identified in only 7% of patients. Until the end of the 1960's, arthrodesis was the treatment of choice in advanced OA of ankle joint. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7282DOI Listing
October 2018

Trabecular Bone Score (TBS) in Clinical Practice - Rewiev.

Ortop Traumatol Rehabil 2018 Oct;20(5):347-359

Zakład Chorób Kości i Stawów, Instytut Fizjoterapii, Uniwersytet Jagielloński - Collegium Medicum, Kraków, Polska / Department of Bone and Joint Diseases, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow.

Bone mineral density (BMD) assessment is the basic method for assessing fracture risk and diagnosing osteoporosis according to the World Health Organization (WHO). Osteoporosis is diagnosed when the T-score at the proximal femur or spine is T≤-2.5; however, 70% of fractures occur in patients who do not fulfil this criterion. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7281DOI Listing
October 2018

Zoledronic Acid Inhibits the RhoA-mediated Amoeboid Motility of Prostate Cancer Cells.

Curr Cancer Drug Targets 2019 Jan 15. Epub 2019 Jan 15.

Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Viale Morgagni 50, 50142 Firenze. Italy.

Background: The bisphosphonate Zoledronic acid (ZA) is a potent osteoclast inhibitor currently used in the clinic to reduce osteoporosis and cancer-induced osteolysis. Moreover, ZA exerts an anti-tumor effect in several tumors. Despite this evidence, the relevance of ZA in prostate cancer (PCa) is not completely understood. Read More

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http://dx.doi.org/10.2174/1568009619666190115142858DOI Listing
January 2019

Estimates of hip fracture incidence in Japan using the National Health Insurance Claim Database in 2012-2015.

Osteoporos Int 2019 Jan 16. Epub 2019 Jan 16.

Department of Public Health, Kindai University Faculty of Medicine, 377-2, Oono-Higashi, Osaka Sayama city, Osaka, 589-8511, Japan.

Using the nationwide health insurance claims database, we found that the age-standardized hip fracture incidence rates in Japan indicated significant increase in males but no significant change in females during 2012-2015. The fracture risk in subjects aged 75-84 years indicated decrease in females but no change in males.

Introduction: Nationwide registry data on hip fractures have not yet been established in Japan. Read More

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http://dx.doi.org/10.1007/s00198-019-04844-8DOI Listing
January 2019

Urinary N-telopeptide: The New Diagnostic Test for Osteoporosis.

Surg J (N Y) 2019 Jan 8;5(1):e1-e4. Epub 2019 Jan 8.

Department of Orthopaedics, Sri Ramachandra University, Chennai, Tamil Nadu, India.

 Osteoporosis is a silent disease until it is complicated by trivial fall fractures. There is an increasing interest within the orthopaedic community in the noninvasive cost-effective measurement of the bone mineral density.  The aim of the study is to assess whether urinary N-telopeptide level can be a new diagnostic tool in diagnosing osteoporosis. Read More

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http://dx.doi.org/10.1055/s-0038-1677483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327719PMC
January 2019

MicroRNA-705 regulates the differentiation of mouse mandible bone marrow mesenchymal stem cells.

PeerJ 2019 10;7:e6279. Epub 2019 Jan 10.

Department of Oral and Maxillofacial Surgery, the Affiliated Stomatology Hospital of Zunyi Medical University, Zunyi, Guizhou, China.

The craniofacial skeleton is the foundation of most stomatological treatments, including prosthodontics and maxillofacial surgery. Although histologically similar to the appendicular skeleton, the craniofacial skeleton manifests many unique properties in response to external stimuli and signals. However, the mandibular or maxillary bone marrow mesenchyme, which is the intrinsic foundation of the functions of craniofacial skeleton, has not been well studied, and its homeostasis mechanism remains elusive. Read More

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https://peerj.com/articles/6279
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http://dx.doi.org/10.7717/peerj.6279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330203PMC
January 2019
1 Read

Clinical Diagnosis of X-Linked Spondyloepiphyseal Dysplasia Tarda and a Novel Missense Mutation in the Sedlin Gene (SEDL).

Int J Endocrinol 2018 10;2018:8263136. Epub 2018 Dec 10.

Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, China.

Objective: Spondyloepiphyseal dysplasia tarda (SEDT) is a rare hereditary bone disease characterized by spinal and epiphyseal anomalies. We identified the disease by gene sequencing in a Chinese pedigree with SEDT.

Methods: We extracted genomic DNA from five members of a four-generation Chinese SEDT kindred with three affected males and then analyzed the genetic mutation by PCR and DNA sequencing. Read More

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https://www.hindawi.com/journals/ije/2018/8263136/
Publisher Site
http://dx.doi.org/10.1155/2018/8263136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311833PMC
December 2018
1 Read

Calcium supplementation from dairy products in the diet of women over the age of 55 from Zabrze (the Silesian Osteoactive Study - nutritional part).

Reumatologia 2018 23;56(6):382-387. Epub 2018 Dec 23.

Department of Orthopaedic Surgery, the Sports-Clinic, Żory, Poland.

Objectives: The primary goal of the study was to assess calcium intake among women over the age of 55.

Material And Methods: The study participants were randomly selected from the female population of Zabrze, a town in the Upper Silesia Region in Poland, making use of the framework of the Silesia Osteoactive Study Project. The Semi-Quantitative Food Frequency Questionnaire (sFFQ) was used for nutritional assessment. Read More

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http://dx.doi.org/10.5114/reum.2018.80716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330677PMC
December 2018

Unravelling the genetics of osteoporosis.

Authors:
Claire Greenhill

Nat Rev Endocrinol 2019 Jan 15. Epub 2019 Jan 15.

Nature Reviews Endocrinology, .

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http://dx.doi.org/10.1038/s41574-019-0158-xDOI Listing
January 2019

Comorbidities in Patients with Rheumatoid Arthritis and Their Association with Patient-reported Outcomes: Results of Claims Data Linked to Questionnaire Survey.

J Rheumatol 2019 Jan 15. Epub 2019 Jan 15.

From the Department for Health Services Research, Carl von Ossietzky University, Oldenburg; Epidemiology, German Rheumatism Research Centre, Berlin; Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany. This study was supported by the German Federal Ministry of Education and Research (01EC1405). A. Luque Ramos, MPH, Department for Health Services Research, Carl von Ossietzky University; I. Redeker, MSc, Epidemiology, German Rheumatism Research Centre; F. Hoffmann, Professor, Department for Health Services Research, Carl von Ossietzky University; J. Callhoff, MSc, Epidemiology, German Rheumatism Research Centre; A. Zink, Professor, Epidemiology, German Rheumatism Research Centre, and Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin; K. Albrecht, MD, Epidemiology, German Rheumatism Research Centre. Address correspondence to A. Luque Ramos, Department for Health Services Research, Carl von Ossietzky University Oldenburg, Ammerländer Heerstrasse 140, 26111 Oldenburg, Germany. E-mail: Accepted for publication October 4, 2018.

Objective: To investigate the prevalence of comorbidities in a population-based cohort of persons with rheumatoid arthritis (RA) compared to matched controls and to examine their association with patient-reported outcomes in a survey sample.

Methods: Data of 96,921 persons with RA [International Classification of Diseases, 10th ed (ICD-10) M05/M06] and 484,605 age- and sex-matched controls without RA of a German statutory health fund were studied regarding 26 selected comorbidities (ICD-10). A self-reported questionnaire, comprising joint counts [(tender joint count (TJC), swollen joint count (SJC)], functional status (Hannover Functional Ability Questionnaire), effect of the disease (Rheumatoid Arthritis Impact of Disease), and well-being (World Health Organization 5-item Well-Being Index; WHO-5) was sent to a random sample of 6193 persons with RA, of whom 3184 responded. Read More

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http://dx.doi.org/10.3899/jrheum.180668DOI Listing
January 2019

BM-MSC-derived exosomes alleviate radiation-induced bone loss by restoring the function of recipient BM-MSCs and activating Wnt/β-catenin signaling.

Stem Cell Res Ther 2019 Jan 15;10(1):30. Epub 2019 Jan 15.

Department of Orthopedics, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, People's Republic of China.

Background: Radiotherapy to cancer patients is inevitably accompanied by normal tissue injury, and the bone is one of the most commonly damaged tissues. Damage to bone marrow mesenchymal stem cells (BM-MSCs) induced by radiation is thought to be a major cause of radiation-induced bone loss. Exosomes exhibit great therapeutic potential in the treatment of osteoporosis, but whether exosomes are involved in radiation-induced bone loss has not been thoroughly elucidated to date. Read More

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http://dx.doi.org/10.1186/s13287-018-1121-9DOI Listing
January 2019

[The study of rs11801197 polymorphism of the calcitonin receptor gene () in Moscow women and children with different level of bone strength].

Vopr Pitan 2017 28;86(1):28-34. Epub 2016 Dec 28.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

The frequency of the polymorphism rs11801197 of calcitonin receptor gene (CALCR) was studied by real-time PCR in 422 Moscow women and children, including pregnant women (n=96), lactating (n=29) and non-pregnant women (n=28) and children (n=269) of preschool (2-6 years, n=76) and school age (7-16 years, n=193) with different levels of bone strength (BS) as determined by ultrasound densitometry. It was found that the decrease in the value of the BS (Z-score<-1) was observed in 60% of women, 54% of preschool children and 48% of school children. In the cohort studied the predominant genotype of rs11801197 polymorphism of CALCR gene was CT (38%), the frequency of the genotypes CC and TT - 31%, C and T allele - 50%. Read More

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http://dx.doi.org/10.24411/0042-8833-2017-00017DOI Listing
December 2016

Effect of a Fracture Liaison Service on the Rate of Subsequent Fracture Among Patients With a Fragility Fracture in the Norwegian Capture the Fracture Initiative (NoFRACT): A Trial Protocol.

JAMA Netw Open 2018 Dec 7;1(8):e185701. Epub 2018 Dec 7.

Department of Clinical Medicine, Arctic University of Norway, Tromsø, Norway.

Importance: Fragility fracture is a major health issue because of the accompanying morbidity, mortality, and financial cost. Despite the high cost to society and personal cost to affected individuals, secondary fracture prevention is suboptimal in Norway, mainly because most patients with osteoporotic fractures do not receive treatment with antiosteoporotic drugs after fracture repair.

Objectives: To improve secondary fracture prevention by introducing a standardized intervention program and to investigate the effect of the program on the rate of subsequent fractures. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.5701DOI Listing
December 2018
2 Reads

Association of Osteoporosis Medication Use After Hip Fracture With Prevention of Subsequent Nonvertebral Fractures: An Instrumental Variable Analysis.

JAMA Netw Open 2018 Jul 6;1(3):e180826. Epub 2018 Jul 6.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Importance: Osteoporosis medication treatment is recommended after hip fracture, yet contemporary estimates of rates of initiation and clinical benefit in the patient population receiving routine care are not well documented.

Objectives: To report osteoporosis treatment initiation rates between January 1, 2004, and September 30, 2015, and to estimate the risk reduction in subsequent nonvertebral fractures associated with treatment initiation in patients with hip fracture.

Design, Setting, And Participants: In this cohort study, data from a commercial insurance claims database from the United States were analyzed. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.0826DOI Listing

Osteoporosis Treatment After Hip Fracture: Bad News and Getting Worse.

Authors:
Douglas C Bauer

JAMA Netw Open 2018 Jul 6;1(3):e180844. Epub 2018 Jul 6.

Department of Medicine, University of California, San Francisco.

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http://dx.doi.org/10.1001/jamanetworkopen.2018.0844DOI Listing

The Radiology of Osteoporotic Vertebral Fractures Revisited.

J Bone Miner Res 2019 Jan 15. Epub 2019 Jan 15.

Department of Radiology and Nuclear Medicine, University Medical Center Rotterdam, Erasmus MC, The Netherlands.

Until recently there has been little evidence available to validate any method by which to make an accurate diagnosis of an osteoporotic vertebral fractures (OVF) from plain radiographs. In part this reflects a lack of a completely satisfactory "gold standard" but primarily relates to an absence of well-designed prospective studies in this context. Historically, OVF were recognized by evidence of macroscopic structural failure in vertebrae using the criteria applied elsewhere in the skeleton. Read More

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http://dx.doi.org/10.1002/jbmr.3669DOI Listing
January 2019
1 Read

Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality.

Am J Physiol Endocrinol Metab 2019 Jan 15. Epub 2019 Jan 15.

Department of Anatomy and Cell Biology, Indiana University School of Medicine, United States.

A goal of osteoporosis therapy is to restore lost bone with structurally sound tissue. Mice lacking the transcription factor Nuclear Matrix Protein 4 (Nmp4, Zfp384, Ciz, ZNF384) respond to several classes of osteoporosis drugs with enhanced bone formation compared to wild type (WT) animals. Nmp4 mesenchymal stem/progenitor cells (MSPCs) exhibit an accelerated and enhanced mineralization during osteoblast differentiation. Read More

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http://dx.doi.org/10.1152/ajpendo.00343.2018DOI Listing
January 2019

Denosumab-related osteonecrosis of the jaw: a report of 2 cases and review of the literature.

Gen Dent 2019 Jan-Feb;67(1):42-46

Bisphosphonates have been implicated in the induction of medication-related osteonecrosis of the jaw (MRONJ) since 2004. Since then, the spectrum of drugs implicated in the onset of MRONJ has broadened to include other antiresorptive and antiangiogenic drugs. Denosumab is an antiresorptive drug that has been on the market since 2010. Read More

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January 2019

Retention of osteocytic micromorphology by sclerostin antibody in a concurrent ovariectomy and functional disuse model.

Ann N Y Acad Sci 2019 Jan 15. Epub 2019 Jan 15.

Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York.

Prolonged mechanical unloading in bedridden patients and concurrent hormonal dysregulation represents the cause of one of the severest forms of osteoporosis, a condition for which there are very few efficacious interventions available to date. Sclerostin, a Wnt antagonist, acts as a negative regulator of bone formation. Sclerostin antibody (Scl-Ab)-mediated blockade of sclerostin can dramatically enhance bone formation and reduce bone resorption. Read More

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http://dx.doi.org/10.1111/nyas.13991DOI Listing
January 2019

Polymethylmethacrylate-augmented fenestreted pedicle-screw fixation in low bone quality patients: a case series and literature review.

J Biol Regul Homeost Agents 2018 Nov-Dec;32(6 Suppl. 1):71-76

Department of Oncologic and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli - Bologna, Italy.

The use of pedicle screws in low bone quality patients implicates risks of secondary implant loosening for grip lack. In fact, the result is a reduced mechanical stability at bone-screw interface and consequently an increased chance of pullout and hardware failure. Augmentation techniques have been described for many years and fenestrated screws that allow cement injection is one of them. Read More

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January 2019

Effects of Sequential Treatment with Intermittent Parathyroid Hormone and Zoledronic Acid on Particle-induced Implant Loosening: Evidence from a Rat Model.

J Orthop Res 2019 Jan 15. Epub 2019 Jan 15.

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, People's Republic of China.

Particle-induced implant loosening is a major challenge to long-term survival of joint prostheses. Administration of intermittent parathyroid hormone (PTH) has shown potential in the treatment of cases of early-stage periprosthetic osteolysis, while sequential administration of intermittent PTH and bisphosphonates has achieved significant effects on treatment of postmenopausal osteoporosis. The objective of this study was to determine whether sequential treatment could preserve bone mass and implant fixation during a pathological course of peri-implant osteolysis in a rat model. Read More

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http://doi.wiley.com/10.1002/jor.24217
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http://dx.doi.org/10.1002/jor.24217DOI Listing
January 2019
1 Read

Osteoporosis knowledge and awareness among university students in Saudi Arabia.

Arch Osteoporos 2019 Jan 14;14(1). Epub 2019 Jan 14.

Biochemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia.

Awareness and knowledge about any disease is the first step to prevent and treat it, so this study evaluates osteoporosis awareness and knowledge in university students. Our results showed a high awareness and good knowledge of osteoporosis. Females were better informed than males. Read More

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http://dx.doi.org/10.1007/s11657-019-0560-yDOI Listing
January 2019

Transient osteoporosis of pregnancy in a case of postpartum bilateral femoral neck fracture.

Int J Reprod Biomed (Yazd) 2018 Oct;16(10):657

Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.

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October 2018

Gossypol Promotes Bone Formation in Ovariectomy-Induced Osteoporosis through Regulating Cell Apoptosis.

Biomed Res Int 2018 13;2018:3635485. Epub 2018 Dec 13.

Department of Orthorpaedic Surgery, Peking Union Medical College Hospital, Beijing 100730, China.

Osteoporosis is among the most common forms of age-related diseases, especially for females, which has been a grave public health problem. Drug therapies have shown promising outcomes to promote bone formation and bone density. This study identified a novel potential drug, gossypol, for the treatment of osteoporosis. Read More

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https://www.hindawi.com/journals/bmri/2018/3635485/
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http://dx.doi.org/10.1155/2018/3635485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311247PMC
December 2018
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Prevalence of vitamin D deficiency in healthy Iranian children: A systematic review and meta-analysis.

Med J Islam Repub Iran 2018 8;32:83. Epub 2018 Sep 8.

Endocrinology Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.

Vitamin D deficiency is related to rickets in children, and it can increase the risk of osteoporosis in adulthood. The aim of our study was to estimate the prevalence of vitamin D deficiency among healthy Iranian children and adolescents. Vitamin D levels less than 20ng/ml and between 20 and 30ng/ml was considered as vitamin D deficiency and insufficiency, respectively. Read More

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http://dx.doi.org/10.14196/mjiri.32.83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325293PMC
September 2018

Changes in bone density and bone quality caused by single fasting for 96 hours in rats.

PeerJ 2019 9;6:e6161. Epub 2019 Jan 9.

Division of Nutritional Science, Graduate School of Human Health Science, University of Nagasaki, Nagasaki, Japan.

Background: Young women occasionally engage in dietary restrictions accompanied by fasting for the purpose of losing weight, but such restrictions have various effects on body functions. The recent increase in the number of people suffering from osteoporosis has become a major social problem mainly in industrialized countries.Therefore, we think it is important to understand the effects of fasting on bone vulnerability, especially to bone quality. Read More

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http://dx.doi.org/10.7717/peerj.6161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330036PMC
January 2019

[Current situation and future issues of antiresorptive agent-related osteonecrosis of the jaw].

Nihon Yakurigaku Zasshi 2019 ;153(1):22-27

Department of Dentistry and Oral Surgery, Hyogo College of Medicine.

Bisphosphonate-related osteonecrosis of the jaw (BRONJ), which is characterized by refractory bone exposure, has recently emerged as a serious side effect of bisphosphonate (BP) treatment. BRONJ was first thought to be due to administration of high doses of intravenous BP to treat metastatic bone lesions or multiple myeloma. However, more recent studies have indicated that BRONJ also frequently occurs in patients receiving low doses of BP for the treatment of osteoporosis. Read More

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http://dx.doi.org/10.1254/fpj.153.22DOI Listing
January 2019

[The mechanism of anti-RANKL antibody in the treatment of metabolic bone diseases including osteoporosis - possible applications of anti-RANKL antibody to the treatment of cancer patients].

Authors:
Hisataka Yasuda

Nihon Yakurigaku Zasshi 2019 ;153(1):11-15

Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd.

Discovery of RANKL (receptor activator of NF-κB ligand) gave a great impact on identification of the mechanisms regulating osteoclast differentiation and function, establishment of research field bridging bone and mineral research and immunology (osteoimmunology), and development of a fully human anti-RANKL monoclonal neutralizing antibody (denosumab). Denosumab has been clinically available for treatment of osteoporosis and cancer-induced bone diseases in the US, Europe and many countries including Japan. Denosumab is a so-called blockbuster of which sales amount was 3. Read More

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http://dx.doi.org/10.1254/fpj.153.11DOI Listing
January 2019

Metabolomics Profiling Reveals Rehmanniae Radix Preparata Extract Protects against Glucocorticoid-Induced Osteoporosis Mainly via Intervening Steroid Hormone Biosynthesis.

Molecules 2019 Jan 11;24(2). Epub 2019 Jan 11.

Department of Pharmacognosy, Second Military Medical University School of Pharmacy, Shanghai 200433, China.

Rehmanniae Radix Preparata (RR), the dry rhizome of Libosch., is a traditional herbal medicine for improving the liver and kidney function. Ample clinical and pharmacological experiments show that RR can prevent post-menopausal osteoporosis and senile osteoporosis. Read More

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http://dx.doi.org/10.3390/molecules24020253DOI Listing
January 2019

[Activity Study of Icarlin and Epimedin C Monomer under the Same Molarity in Osteoporosis Ze- brafish Model].

Zhongguo Zhong Xi Yi Jie He Za Zhi 2016 08;36(8):986-990

Objective To evaluate anti-osteoporotic activity of icariin and Epimedin C monomer under the same molarity in predinsolone-induced osteoporosis zebrafish. Methods Zebrafish larvae after 4-day fertilization were divided into group S [0. 5% dimethyl sulfoxide (DMSO) , A (25 μmol/L prednisolone, 0. Read More

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August 2016
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Normocalcemic Hyperparathyroidism.

Authors:
Sabrina Corbetta

Front Horm Res 2019 19;51:23-39. Epub 2018 Nov 19.

Parathyroid hormone (PTH) disorders are characterized by a wide spectrum of clinical and biochemical presentations. The increasing use of serum PTH assay in the set of the diagnostic workout in patients with osteoporosis has identified patients with features of surgically confirmed primary hyperparathyroidism (PHPT) associated with persistent normal serum calcium levels, which has been recognized as a distinct entity from hypercalcemic PHPT (HPHPT) by the last international consensus. Normocalcemic PHPT (NPHPT) affects about 6-8% of PHPT patients. Read More

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http://dx.doi.org/10.1159/000491036DOI Listing
November 2018

Factors associated with receiving bone mineral density screening among people with multiple sclerosis.

Mult Scler Relat Disord 2019 Jan 8;28:305-308. Epub 2019 Jan 8.

School of Rehabilitation Therapy, Faculty of Health Sciences, Queen's University, Kingston, Ontario, CANADA.

Background: Accidental falls and fall-related injuries are common among people with multiple sclerosis (MS). Fractures are the most common injury, pointing to the need to understand current practices related to bone health management in this population. We sought to identify factors associated with bone mineral density (BMD) screening, using dual-energy X-ray absorptiometry, among people with MS. Read More

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http://dx.doi.org/10.1016/j.msard.2019.01.022DOI Listing
January 2019

Mast cells in mastocytosis and allergy - Important player in metabolic and immunological homeostasis.

Adv Med Sci 2019 Jan 11;64(1):124-130. Epub 2019 Jan 11.

Department of General and Medical Biochemistry, University of Gdańsk, Gdańsk, Poland.

The role of mast cell (MC) activity in pathophysiology is complex and challenging and its clinical effects are difficult to predict. Apart from the known role of MCs in basic immunological processes and allergy, underlined is their importance in bone mineralization and in regulation of autoimmune reactions. Mast cell mediators, especially those released from mast cells in degranulation, but also those released constitutively, are important both in metabolic and immunological processes. Read More

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http://dx.doi.org/10.1016/j.advms.2018.08.013DOI Listing
January 2019