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Soc Sci Med 2022 Jun 17;306:115155. Epub 2022 Jun 17.

Healthy High Density Cities Lab, The University of Hong Kong, Hong Kong; Faculty of Architecture, The University of Hong Kong, Hong Kong. Electronic address:

Background: Built environment can influence physical conditions of older adults (e.g. osteoporosis). Read More

Pathol Res Pract 2022 Jun 17;236:153985. Epub 2022 Jun 17.

Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China. Electronic address:

Background: Postmenopausal osteoporosis (PMOP) is the most common bone metabolic disease affecting women worldwide. In this study, we investigate the role of long non-coding RNA (lncRNA) expression in exosomes obtained from bone marrow mesenchymal stem cells (BMSCs) of patients with PMOP.

Methods: BMSCs from patients diagnosed with PMOP and healthy post-menopausal females as controls were isolated and cultured before exosome extraction. Read More

Seizure 2022 Jun 16;100:36-43. Epub 2022 Jun 16.

Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, University Hospital Frankfurt, Goethe-University Frankfurt, Frankfurt am Main, Germany; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, Frankfurt am Main, Germany.

Objective: Epilepsy is a chronic condition that can affect patients of all ages. Women with epilepsy (WWE) require access to specific counseling and information regarding issues related to contraception, pregnancy, and hormonal effects on seizure control and bone mineral density. This study investigated the knowledge among WWE regarding their condition, and whether epilepsy-specific knowledge has improved over the last 15 years. Read More

Curr Opin Endocrinol Diabetes Obes 2022 Jun 27. Epub 2022 Jun 27.

Department of Medicine (C5121), University of Manitoba, Winnipeg, Manitoba, Canada.

Purpose Of Review: Type 1 (T1D) and 2 diabetes (T2D) are associated with increased risk of fracture independent of bone mineral density (BMD). Fracture risk prediction tools can identify individuals at highest risk, and therefore, most likely to benefit from antifracture therapy. This review summarizes recent advances in fracture prediction tools as applied to individuals with diabetes. Read More

Osteoporos Int 2022 Jun 24. Epub 2022 Jun 24.

Division of Nephrology, Bone and Mineral Metabolism, University of Kentucky, 800 Rose Street, Room MN-560, Lexington, KY, 40536-0298, USA.

Patients with CKD have a 4-fivefold higher rate of fractures. The incidence of fractures increases with deterioration of kidney function. The process of skeletal changes in CKD patients is characterized by compromised bone strength because of deterioration of bone quantity and/or quality. Read More

Aging (Albany NY) 2022 Jun 21;14(undefined). Epub 2022 Jun 21.

School of Public Health, National Defense Medical Center, Taipei, Taiwan, R.O.C.

Background: Identification of candidate SNPs from transcription factors (TFs) is a novel concept, while systematic large-scale studies on these SNPs are scarce.

Purpose: This study aimed to identify the SNPs of six TF binding sites (TFBSs) and examine the association between candidate SNPs and osteoporosis.

Methods: We used the Taiwan BioBank database; University of California, Santa Cruz, reference genome; and a chromatin immunoprecipitation sequencing database to detect 14 SNPs at the potential binding sites of six TFs. Read More

J Bone Miner Res 2022 Jun 24. Epub 2022 Jun 24.

Department of Oncology and Metabolism, The University of Sheffield, Sheffield, S10 2RX, U.K.

The risk of osteoporotic fracture is inversely related to bone mineral density (BMD), but how spatial BMD pattern influences fracture risk remains incompletely understood. This study used a pixel-level spatio-temporal atlas of proximal femoral BMD in 13,338 white European women (age 20 to 97 years) to quantitate age-related texture variation in BMD maps and generate a 'reference' map of bone ageing. We introduce a new index, called Densitometric Bone Age (DBA), as the age at which an individual site-specific BMD map (the proximal femur is studied here) best matches the median ageing trajectory at that site in terms of the root mean squared error (RMSE). Read More

Yonsei Med J 2022 Jul;63(7):648-656

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.

Purpose: In women, menopause manifests with a variety of symptoms related to sex-hormone deficiency. Supplementing steroid hormones with pharmacological drugs has been widely practiced. However, considering the possible complications associated with artificial hormone therapy, studies have been conducted to find an alternative to pharmacological hormone replacement therapy. Read More

Acta Endocrinol (Buchar) 2021 Oct-Dec;17(4):537-542

University of California San Diego, La Jolla, California, United States of America.

We describe clinical features of women with extremely low bone density, and investigate secondary causes of osteoporosis. Our hypothesis was that this population would be enriched in identifiable causes of osteoporosis. We performed a retrospective review of medical records of all women seen at our university over 4 years with T-score on bone densitometry at/below -4 at any site. Read More

Acta Endocrinol (Buchar) 2021 Oct-Dec;17(4):509-516

"Iuliu Hațieganu" University of Medicine and Pharmacy, 2 Internal Medicine Department, Cluj-Napoca, Romania.

Recent studies suggest that osteopontin (OPN) could be used as an early marker for the diagnosis of bone disorders. Considering the contradictory opinions in the literature, the objective of this systematic review is to analyse the current information regarding the relationship between OPN and bone mineral density (BMD), which represents an important process in the development of osteoporosis. We performed a literature search of clinical trials using the PubMed database, published between 1999-2020, and identified 7 studies that were eligible for analysis. Read More

Acta Endocrinol (Buchar) 2021 Oct-Dec;17(4):498-502

"C.I.Parhon" National Institute of Endocrinology, Bucharest, Romania.

Context: Parental history of osteoporosis is associated with an increased risk of fracture. However, there are not many data on the mechanism of action.Our objective was to determine if heredity influences fracture rate: independently or through the bone mineral density; to identify also the strongest independent risk factors of osteoporotic fractures among our study population. Read More

ERJ Open Res 2022 Apr 20;8(2). Epub 2022 Jun 20.

Graduate Program in Pathology, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil.

Purpose: The aim of this study was to analyse and quantify the prevalence of six comorbidities from lung cancer screening (LCS) on computed tomography (CT) scans of patients from developing countries.

Methods: For this retrospective study, low-dose CT scans (n=775) were examined from patients who underwent LCS in a tertiary hospital between 2016 and 2020. An age- and sex-matched control group was obtained for comparison (n=370). Read More

EClinicalMedicine 2022 Jul 8;49:101488. Epub 2022 Jun 8.

Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong.

Background: Accumulating evidence suggests the interaction of bone metabolism and the immune system, but how bone health is associated with the risk of infections remains unknown.

Methods: This study aimed to investigate the relationship of bone mineral density (BMD) with the risk of common infections and sepsis in Hong Kong Osteoporosis Study (HKOS). A prospective cohort study, initiated in 1995 and followed until 31 December 2020, of 5,717 participants examined the association of BMD at three skeletal sites (lumbar spine, femoral neck, and total hip) with common infections - pneumonia, urinary tract infection (UTI), skin infection, and sepsis. Read More

Viruses 2022 Jun 20;14(6). Epub 2022 Jun 20.

Unit of Infectious and Tropical Diseases, Department of Medical and Surgical Sciences, "Magna Graecia" University, 88100 Catanzaro, Italy.

Comorbidities in people living with HIV (PLWH) represent a major clinical challenge today, and metabolic syndrome (MTBS) is one of the most important. Our objective was to assess the prevalence of MTBS and the role of both clinical/socio-behavioral risk factors for MTBS in a cohort of PLWH. All PLWH, over 18 years of age, attending all Infectious Disease Units in Calabria Region (Southern Italy) for their routine checks from October 2019-January 2020 were enrolled. Read More

Nutrients 2022 Jun 18;14(12). Epub 2022 Jun 18.

Department of Family Practice and Community Health, Ajou University Hospital, Ajou University, Suwon 16499, Korea.

Few studies have investigated the effects of calcium supplementation on cardiovascular outcomes in individuals with low calcium intake in real-world settings. This study examined the association between calcium supplementation and cardiovascular outcomes in the Korean population in a real-world setting. This large retrospective cohort study included patients aged ≥45 years first prescribed calcium supplements in 2010. Read More

Nutrients 2022 Jun 15;14(12). Epub 2022 Jun 15.

Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong 999077, China.

Amino acids (AAs) and dietary inflammatory potential play essential roles in muscle health. We examined the associations of dietary inflammatory index (DII) of habitual diet with serum AA profile, and ascertained if the associations between DII and muscle outcomes were mediated by serum AAs, in 2994 older Chinese community-dwelling men and women (mean age 72 years) in Hong Kong. Higher serum branched chain AAs (BCAAs), aromatic AAs and total glutathione (tGSH) were generally associated with better muscle status at baseline. Read More

Nutrients 2022 Jun 14;14(12). Epub 2022 Jun 14.

Institute for Public Health and Nursing Research (IPP), University of Bremen, 28359 Bremen, Germany.

Sustaining good bone health into older age is key for preventing osteoporosis. Bone health is associated with several lifestyle factors. This study investigates older adults' adherence to bone health-promoting lifestyle recommendations dependent on osteoporosis status. Read More

Nutrients 2022 Jun 7;14(12). Epub 2022 Jun 7.

Bone Metabolic Diseases Unit, Department of Experimental, Clinical and Biomedical Sciences, University of Florence, 50139 Florence, Italy.

Both osteoporosis with related fragility fractures and cardiovascular diseases are rapidly outspreading worldwide. Since they are often coexistent in elderly patients and may be related to possible common pathogenetic mechanisms, the possible reciprocal effects of drugs employed to treat these diseases have to be considered in clinical practice. Bisphosphonates, the agents most largely employed to decrease bone fragility, have been shown to be overall safe with respect to cardiovascular diseases and even capable of reducing cardiovascular morbidity in some settings, as mainly shown by real life studies. Read More

Molecules 2022 Jun 19;27(12). Epub 2022 Jun 19.

Unit of Metabolic Bone and Thyroid Disorders, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy.

The dipeptidyl peptidase 3 () is a ubiquitous zinc-dependent aminopeptidase, participating in the activation or degradation of signaling peptides and in the Keap1-Nrf2 antioxidant pathway. The absence of in the knockout mouse model causes increased osteoclast activity, altered osteogenic function, sustained oxidative stress in the bone tissue, and bone loss. We aimed to assess the association of activity with bone fragility in postmenopausal osteoporosis and the impact of denosumab on enzymatic activity. Read More

Molecules 2022 Jun 14;27(12). Epub 2022 Jun 14.

State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.

The anthraquinones (AQs) and derivatives are widely distributed in nature, including plants, fungi, and insects, with effects of anti-inflammation and anti-oxidation, antibacterial and antiviral, anti-osteoporosis, anti-tumor, etc. Inflammation, including acute and chronic, is a comprehensive response to foreign pathogens under a variety of physiological and pathological processes. AQs could attenuate symptoms and tissue damages through anti-inflammatory or immuno-modulatory effects. Read More

Molecules 2022 Jun 8;27(12). Epub 2022 Jun 8.

Macau Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China.

Oliver () is a popular medicinal herb and health supplement in China, Japan, and Korea, and has a variety of pharmaceutical properties. The neuroendocrine-immune (NEI) network is crucial in maintaining homeostasis and physical or psychological functions at a holistic level, consistent with the regulatory theory of natural medicine. This review aims to systematically summarize the chemical compositions, biological roles, and pharmacological properties of to build a bridge between it and NEI-associated diseases and to provide a perspective for the development of its new clinical applications. Read More

Molecules 2022 Jun 8;27(12). Epub 2022 Jun 8.

Department of Agricultural Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada.

Multiple strategies including the use of bioactive peptides and other nutraceuticals are being adopted to maintain bone health. This study provides an improved and deeper understanding of the pharmacological effects that a bioactive peptide IRW (Ile-Arg-Trp) extends on bone health. Our results showed that IRW treatment protects osteoblasts against Ang II induced decline in cell proliferation and restores protein levels of collagen type I alpha 2 chain (COL1A2) and alkaline phosphatase (ALP) levels in MC3T3-E1 cells ( < 0. Read More

Medicina (Kaunas) 2022 Jun 19;58(6). Epub 2022 Jun 19.

Department of Psycho Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.

: Quarantine, isolation and bed rest associated with COVID-19 infection favored the loss of muscle and bone mass, especially in elderly patients. The current study aims to compare the presence of sarcopenia and osteoporosis in patients with a recent (one month) history of SARS-CoV-2 infection versus the general population. : A cross-sectional study was conducted in which 157 patients were enrolled, divided into two groups, comparable in structure. Read More

Medicina (Kaunas) 2022 Jun 15;58(6). Epub 2022 Jun 15.

Klinik für Orthopädie, Unfallchirurgie und Sporttraumatologie, Marienhaus Klinikum Hetzelstift, 67434 Neustadt an der Weinstraße, Germany.

: The number of geriatric patients presenting with fragility fractures of the pelvis is increasing due to ageing Western societies. There are nonoperative and several operative treatment approaches. Many of which cause prolonged hospitalisation, so patients become bedridden and lose mobility and independence. Read More

Medicina (Kaunas) 2022 Jun 8;58(6). Epub 2022 Jun 8.

Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 62247, Taiwan.

: To study the risk of spine surgery, including cervical and lumbar spine surgeries in patients with rheumatoid arthritis (RA) compared with those without a diagnosis of RA. : This is a secondary data analysis using population-based health claim data. We identified newly diagnosed adult patients with RA between January 2000 and December 2012, according to the International Classification of Diseases, Ninth revision, clinical modification code 714. Read More

Medicina (Kaunas) 2022 Jun 6;58(6). Epub 2022 Jun 6.

Department of Biomedical Sciences, Dental Sciences and Morpho-Functional Imaging, University of Messina, AOU "G. Martino", 98125 Messina, Italy.

: Bones and the skeletal muscle play a key role in human physiology as regulators of metabolism in the whole organism. Bone tissue is identified as a complex and dynamic living unit that could react to physical activity. Hormones, growth factors, signaling factors, and environmental factors control osteogenesis, and it could be regulated at a post-transcriptional level. Read More

Medicina (Kaunas) 2022 May 31;58(6). Epub 2022 May 31.

Department of Neurosurgery, University Medical Center, 55131 Mainz, Germany.

Age-related loss of bone and muscle mass are signs of frailty and are associated with an increased risk of falls and consecutive vertebral fractures. Management often necessitates fusion surgery. We determined the impacts of sarcopenia and bone density on implant failures (IFs) and complications in patients with spondylodesis due to osteoporotic vertebral fractures (OVFs). Read More

Medicina (Kaunas) 2022 May 24;58(6). Epub 2022 May 24.

Faculty of Sports Sciences, Department of Physiotherapy, Universidad Europea de Madrid, 28670 Madrid, Spain.

Osteoporotic hyperkyphosis is associated with adverse outcomes, such as fatigue, back pain, or reduced back extensor strength, with a negative impact on functionality and quality of life. The purpose of this review is to assess the effectiveness of spinal orthosis on these adverse effects. A systematic review following the PRISMA guidelines was performed. Read More

J Clin Med 2022 Jun 20;11(12). Epub 2022 Jun 20.

Department of Pharmacology and Pharmacoeconomics, Pomeranian Medical University, 71-230 Szczecin, Poland.

Hyperandrogenism is the most common endocrine disorder in women, characterized by an imbalance of normal estrogen and androgen levels in the blood. Androgens play an important role in the female body because they influence bone mineral density (BMD), body mass composition, muscle mass, mental state, and the regulation of sexual function. The reduced activity of aromatase, due to mutations in the gene, reduces the estrogen pool in favor of androgens. Read More

J Clin Med 2022 Jun 13;11(12). Epub 2022 Jun 13.

Department of Diagnostics, Poznan University of Medical Sciences, 67-701 Poznan, Poland.

Background: The study aimed to evaluate radiomorphometric indices derived from panoramic X-rays and selected blood markers of bone turnover and neutrophil extracellular traps, with a view to identifying hemophilic patients at risk of developing osteoporosis.

Methods: The study consisted of 50 adult men with hemophilia A and B (mild, moderate, and severe). The control group consisted of 25 healthy adult men. Read More