83,077 results match your criteria Osteoporosis


Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP suppresses osteoclast formation and promotes osteoblast differentiation through the inhibition of the NF-κB signaling pathway.

FASEB J 2019 Mar 20:fj201802364RR. Epub 2019 Mar 20.

Department of Orthopedics, Affiliated Lishui Hospital of Zhejiang University-the Fifth Affiliated Hospital of Wenzhou University-Lishui Central Hospital, Lishui, China.

Current pharmacological intervention for the treatment of osteolytic bone diseases such as osteoporosis focuses on the prevention of excessive osteoclastic bone resorption but does not enhance osteoblast-mediated bone formation. In our study, we have shown that 4-iodo-6-phenylpyrimidine (4-IPP), an irreversible inhibitor of macrophage migration inhibitory factor (MIF), can inhibit receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis and potentiate osteoblast-mediated mineralization and bone nodule formation in vitro. Mechanistically, 4-IPP inhibited RANKL-induced p65 phosphorylation and nuclear translocation by preventing the interaction of MIF with thioredoxin-interacting protein-p65 complexes. Read More

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http://dx.doi.org/10.1096/fj.201802364RRDOI Listing

Overview of RAW264.7 for osteoclastogensis study: Phenotype and stimuli.

J Cell Mol Med 2019 Mar 20. Epub 2019 Mar 20.

Department of Spine, School of Medicine, Honghui-hospital, Xi'an Jiaotong University, Xi'an, China.

Bone homeostasis is preserved by the balance of maintaining between the activity of osteogenesis and osteoclastogenesis. However, investigations for the osteoclastogenesis were hampered by considerable difficulties associated with isolating and culturing osteoclast in vivo. As the alternative, stimuli-induced osteoclasts formation from RAW264. Read More

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http://dx.doi.org/10.1111/jcmm.14277DOI Listing

Lactose intolerance: what is a correct management?

Rev Assoc Med Bras (1992) 2019 Feb;65(2):270-275

Life Sciences Department, State University of Bahia, Rua Silveira Martins, 2555, Cabula. 41150-000, Salvador, Bahia, Brasil.

Individuals with Lactose Intolerance (LI) tend to exclude milk from their diet since this behavior seems to relieve the symptoms caused by the disease. However, milk is a food of high nutritional value, and complete exclusion of dairy products may favor the development of bone diseases such as osteopenia and osteoporosis. The objective of this review was to evaluate the scientific evidence on the adequate management of patients with LI. Read More

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http://dx.doi.org/10.1590/1806-9282.65.2.270DOI Listing
February 2019

Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study.

Clinics (Sao Paulo) 2019 Mar 14;74:e739. Epub 2019 Mar 14.

Department of Biostatistics and Medical Informatics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.

Objective: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated.

Method: DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. Read More

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http://dx.doi.org/10.6061/clinics/2019/e739DOI Listing

Application of bone transgenic zebrafish in anti-osteoporosis chemical screening.

Animal Model Exp Med 2018 Mar 19;1(1):53-61. Epub 2018 Apr 19.

Affiliated Hospital of Guangdong Medical University Zhanjiang Guangdong Province China.

Background: The zebrafish () has recently been shown to be an ideal model to study bone disease including osteoporosis. The zebrafish osteoporosis model could be induced by glucocorticoid treatment with chemical staining for reflecting the level of bone mineralization. However, this methodology was unstable. Read More

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http://dx.doi.org/10.1002/ame2.12000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354313PMC

monitoring and high-resolution characterizing of the prednisolone-induced osteoporotic process on adult zebrafish by optical coherence tomography.

Biomed Opt Express 2019 Mar 11;10(3):1184-1195. Epub 2019 Feb 11.

School of Basic Medical Science, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 511436, China.

Because of its similar genetic makeup with humans, zebrafish are an available and well-established osteoporosis model for anti-osteoporosis drug development as well as the drug safety-evaluation process. However, few optical imaging methods could effectively visualize the bone of adult zebrafish due to their limited penetration depth. In this paper, high-resolution and long-term characterization of a prednisolone-induced osteoporotic zebrafish model was achieved with spectral-domain optical coherence tomography (SD-OCT). Read More

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https://www.osapublishing.org/abstract.cfm?URI=boe-10-3-1184
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http://dx.doi.org/10.1364/BOE.10.001184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420289PMC
March 2019
3 Reads

A Novel Homozygous Frameshift Variant in Causes Spondyloocular Syndrome in a Consanguineous Pakistani Family.

Front Genet 2019 5;10:144. Epub 2019 Mar 5.

Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan.

We report on three new patients with spondyloocular syndrome (SOS) in a consanguineous Pakistani family. All three patients present progressive generalized osteoporosis, short stature, recurrent fractures, hearing loss and visual impairments. WES revealed a novel homozygous frameshift variant in exon 11 of (NG 012175. Read More

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http://dx.doi.org/10.3389/fgene.2019.00144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411848PMC

Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density.

Nat Commun 2019 Mar 19;10(1):1260. Epub 2019 Mar 19.

Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, 19104, PA, USA.

Osteoporosis is a devastating disease with an essential genetic component. GWAS have discovered genetic signals robustly associated with bone mineral density (BMD), but not the precise localization of effector genes. Here, we carry out physical and direct variant to gene mapping in human mesenchymal progenitor cell-derived osteoblasts employing a massively parallel, high resolution Capture C based method in order to simultaneously characterize the genome-wide interactions of all human promoters. Read More

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http://dx.doi.org/10.1038/s41467-019-09302-xDOI Listing

Is Routine MRI of the Spine Necessary in Trauma Patients with Ankylosing Spinal Disorders or is a CT Scan Sufficient?

Spine J 2019 Mar 16. Epub 2019 Mar 16.

Department of Orthopaedics and Sport Medicine, Harborview Medical Center, 325 Ninth Avenue Seattle, WA 98104, USA. Electronic address:

Background: Ankylosing spinal disorder (ASD) patients are at a greater risk for spinal fractures due to osteoporosis and rigidity of the spinal column. These fractures are associated with a high risk of neurologic compromise resulting from delayed or missed diagnoses. Although CT is usually the initial imaging modality, MRI has been proposed as mandatory to help identify spinal injuries in ASD patients with unexplained neck or back pain or known injuries to help identify non-contiguous fractures. Read More

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http://dx.doi.org/10.1016/j.spinee.2019.03.004DOI Listing

A polymorphism rs6815464 in the macrophage erythroblast attacher gene is associated with low bone mineral density in postmenopausal Japanese women.

Gene 2019 Mar 16. Epub 2019 Mar 16.

Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Background And Purposes: Osteoporosis and osteopenia are multifactorial diseases characterized by low bone mineral density (BMD) and are susceptible to genetic and environmental risk factors. The macrophage erythroblast attacher (MAEA) was discovered as a protein to mediate the attachment of erythroid cells to macrophages and is essential for bone marrow hematopoiesis. MAEA is expressed in a wide range of cells and tissues including osteoblasts and osteoclasts. Read More

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http://dx.doi.org/10.1016/j.gene.2019.03.027DOI Listing

Teriparatide versus bisphosphonates for treatment of postmenopausal osteoporosis: A meta-analysis.

Int J Surg 2019 Mar 16. Epub 2019 Mar 16.

Department of Rheumatology, Dongguan People's Hospital,Southern Medical University, 523059.

Objective: This meta-analysis aims to compare the efficacy of teriparatide and bisphosphonates for reducing vertebral fracture risk and bone mineral density (BMD) in lumbar spine and femoral neck in postmenopausal women with osteoporosis.

Methods: We searched the literature, via PubMed, Embase, Cochrane Library, Web of Science and Google database to screen citations from inception to April 2018 for inclusion in this study. Only randomized controlled trials that compared teriparatide and bisphosphonates for reducing vertebral fracture risk in postmenopausal women with osteoporosis were included. Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.03.004DOI Listing

Mechanical regulation of bone formation and resorption around implants in a mouse model of osteopenic bone.

J R Soc Interface 2019 Mar;16(152):20180667

1 Institute for Biomechanics, ETH Zurich , Zurich , Switzerland.

Although mechanical stimulation is considered a promising approach to accelerate implant integration, our understanding of load-driven bone formation and resorption around implants is still limited. This lack of knowledge may delay the development of effective loading protocols to prevent implant loosening, especially in osteoporosis. In healthy bone, formation and resorption are mechanoregulated processes. Read More

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http://dx.doi.org/10.1098/rsif.2018.0667DOI Listing

The Role of Tocotrienol in Preventing Male Osteoporosis-A Review of Current Evidence.

Int J Mol Sci 2019 Mar 18;20(6). Epub 2019 Mar 18.

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Malaysia.

Male osteoporosis is a significant but undetermined healthcare problem. Men suffer from a higher mortality rate post-fracture than women and they are marginalized in osteoporosis treatment. The current prophylactic agents for osteoporosis are limited. Read More

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http://dx.doi.org/10.3390/ijms20061355DOI Listing

Multiorgan toxicity induced by EtOH extract of Fructus Psoraleae in Wistar rats.

Phytomedicine 2019 Feb 25;58:152874. Epub 2019 Feb 25.

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, PR China. Electronic address:

Background: The fruits of Psoralea corylifolia L. (Fructus Psoraleae, FP) has a long history and a wide range of applications in the treatment of osteoporosis and leukoderma. Although it is well known that FP could cause hepatotoxicity and reproductive toxicity, less is known about its potential toxicity on multiple organs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09447113193004
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http://dx.doi.org/10.1016/j.phymed.2019.152874DOI Listing
February 2019
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Osteoprotective Effects of Tribulus terrestris L.: Relationship Between Dehydroepiandrosterone Levels and Ca-Sparing Effect.

J Med Food 2019 Mar;22(3):241-247

1 Laboratory of Pre-Clinical Research of Natural Products, Paranaense University, Umuarama, PR, Brazil.

Osteoporosis is a systemic bone disease that is characterized by impairments in bone strength that predispose an individual to a higher risk of fractures. Despite the various etiologies, undoubtedly the most important factors are aging of the population and hypogonadism. Although several therapeutic options are available, pharmacological treatments have some risks. Read More

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http://dx.doi.org/10.1089/jmf.2018.0090DOI Listing

Osteoporosis and the Ageing Skeleton.

Subcell Biochem 2019 ;91:453-476

Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK.

Osteoporosis is a "skeletal disorder characterized by compromised bone strength predisposing a person to an increased risk of fracture" which, in light of demographic change, is becoming an increasing burden on health care worldwide. Increasing age and female gender are associated with the condition, although a wider range of clinical risk factors are being used increasingly to identify those at risk of osteoporosis and its most important sequelae, fracture.While osteoporosis and fracture have long been associated with women in the post-menopausal age, fracture incidence increases because of the ageing of our population. Read More

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http://dx.doi.org/10.1007/978-981-13-3681-2_16DOI Listing
January 2019

Connective Tissue and Age-Related Diseases.

Subcell Biochem 2019 ;91:281-310

Department of Pathology, College of Veterinary Medicine, The University of Georgia and AU/UGA Medical Partnership, Athens, GA, USA.

We begin this chapter by describing normal characteristics of several pertinent connective tissue components, and some of the basic changes they undergo with ageing. These alterations are not necessarily tied to any specific disease or disorders, but rather an essential part of the normal ageing process. The general features of age-induced changes, such as skin wrinkles, in selected organs with high content of connective or soft tissues are discussed in the next part of the chapter. Read More

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http://dx.doi.org/10.1007/978-981-13-3681-2_11DOI Listing
January 2019

Predicting osteoporosis medication receipt in Veterans with a spinal cord injury: A retrospective cohort study.

J Spinal Cord Med 2019 Mar 19:1-8. Epub 2019 Mar 19.

c Charlie Norwood Veterans Affairs Medical Center , Augusta , Georgia , USA.

Objective: To describe frequency and predictors of use of pharmacological therapies for osteoporosis in persons with a spinal cord injury (SCI).

Design: Retrospective cohort study.

Setting: United States Veterans Health Administration (VA) national databases. Read More

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http://dx.doi.org/10.1080/10790268.2019.1584259DOI Listing

A new biosensor for osteoporosis detection.

Prep Biochem Biotechnol 2019 Mar 19:1-10. Epub 2019 Mar 19.

b Department of Chemistry, Faculty of Science , Trakya University , Edirne , Turkey.

Osteoporosis is a disease that is characterized by deterioration of bone tissue and increased risk of fracture as it leads to a decrease in bone mineral density, which is an important public health problem. Today, bone mineral density is measured by radiological techniques. Alternative techniques are needed because of the disadvantages such as excessive radiation intake, the cost of radiological techniques, and the necessity for specialist personnel for the devices. Read More

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http://dx.doi.org/10.1080/10826068.2019.1587628DOI Listing

Anti-Fracture Efficacy of Zoledronate in Subgroups of Osteopenic Postmenopausal Women: Secondary Analysis of a Randomized Controlled Trial.

J Intern Med 2019 Mar 18. Epub 2019 Mar 18.

Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Background: We recently reported that the administration of zoledronate every 18 months to osteopenic older women reduces the incidence of fractures.

Objective: Here we present a more detailed analysis of that trial to determine whether baseline clinical characteristics impact on the anti-fracture efficacy of this intervention.

Methods: This is a prospective, randomized, placebo-controlled, double-blind trial in osteopenic postmenopausal women aged ≥65 years, to determine the anti-fracture efficacy of zoledronate. Read More

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http://dx.doi.org/10.1111/joim.12901DOI Listing

Stimulatory effects of platycodin D on osteoblast differentiation.

J Cell Biochem 2019 Mar 19. Epub 2019 Mar 19.

College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju, Republic of Korea.

Previous studies have suggested that platycodin D is implicated in bone biology and ameliorates osteoporosis development. Platycodin D repressed the osteoclast activity and enhanced bone mineral density in the mouse model. However, the effects of platycodin D on osteoblast differentiation have not been elucidated yet. Read More

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http://dx.doi.org/10.1002/jcb.28580DOI Listing

Icariin promotes osteogenic differentiation of bone marrow stromal cells and prevents bone loss in OVX mice via activating autophagy.

J Cell Biochem 2019 Mar 19. Epub 2019 Mar 19.

Department of Orthopaedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.

Osteoporosis (OP) results from the impaired function of endogenous bone marrow mesenchymal stem cells (BMSCs). Icariin (ICA) has shown potential osteoprotective effects. However, the molecular mechanism for the anabolic action of ICA remains largely unknown. Read More

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http://dx.doi.org/10.1002/jcb.28585DOI Listing

Management of Fragility Hip Fractures: Our Institutional Experience.

Geriatr Orthop Surg Rehabil 2019 11;10:2151459319828618. Epub 2019 Mar 11.

Department of Orthopaedic Surgery, Virginia Commonwealth University, Richmond, VA, USA.

Introduction: Approximately 320 000 fragility hip fractures are sustained in the United States annually, resulting in substantial morbidity and mortality as well as significant economic burden on the health-care system. Nevertheless, a majority of these patients are not screened and do not receive treatment for osteoporosis. The objective of this study was to evaluate rates of osteoporosis screening and treatment in our institution and compare them to those reported in the literature. Read More

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http://dx.doi.org/10.1177/2151459319828618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413423PMC

Palliative Management of Nonoperative Femoral Neck Fractures With Continuous Peripheral Indwelling Catheters: Case-Control Series.

Geriatr Orthop Surg Rehabil 2019 11;10:2151459319827470. Epub 2019 Mar 11.

Department of Orthopedic Surgery, WellSpan York Hospital, York, PA, USA.

Introduction: This case-control study evaluates the success of indwelling pain catheters in nonoperatively treated femoral neck fractures (FNFs) for end-of-life pain management.

Methods: Patients older than 65 years with nonoperatively treated FNFs were retrospectively identified at a level 1 trauma center between March 2012 and September 2015. Twenty-three received indwelling continuous peripheral pain catheters (experimental) and 10 received traditional pain control modalities (control). Read More

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http://dx.doi.org/10.1177/2151459319827470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413429PMC

Repurposing the selective estrogen receptor modulator to suppress gastrointestinal cancer growth.

EMBO Mol Med 2019 Mar 18. Epub 2019 Mar 18.

Olivia Newton-John Cancer Research Institute, School of Cancer Medicine, La Trobe University, Heidelberg, Vic., Australia

Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in solid malignancies and promotes their progression. Here, we established the utility of a steroid analog clinically approved for the treatment of osteoporosis, to suppress gp130-dependent tumor growth of the gastrointestinal epithelium. administration reduced gastric tumor burden in mice, where tumors arise exclusively through excessive gp130/STAT3 signaling in response to the IL6 family cytokine IL11. Read More

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http://dx.doi.org/10.15252/emmm.201809539DOI Listing

Ctrp4, a new adipokine, promotes the differentiation of osteoblasts.

Biochem Biophys Res Commun 2019 Mar 15. Epub 2019 Mar 15.

Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xi'an, Shaanxi, 710032, PR China. Electronic address:

Recent evidence suggests that adipokines are involved in the regulation of bone metabolism. Ctrp4 is a newly discovered member of the adipokine CTRP family. Studies have shown that Ctrp4 is involved in the regulation of tumor cell inflammatory signaling pathways and acts on the hypothalamus to regulate food intake, but its role in osteoblasts is not yet clear. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.053DOI Listing

There is an association between sarcopenia, osteoporosis, and the risk of hip fracture.

Authors:
O Şahap Atik

Eklem Hastalik Cerrahisi 2019 Apr;30(1)

Professor of Orthopedic Surgery, Turkish Joint Diseases Foundation, Ankara, Turkey.

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http://dx.doi.org/10.5606/ehc.2019.001DOI Listing

[Effect of salmon calcitonin on postoperative humeral head replacement in elderly patients].

Zhongguo Gu Shang 2019 Feb;32(2):136-140

Chengde Medical College Affiliated Hospital, Chengde 067000, Hebei, China;

Objective: To observe the effect of anti-osteoporosis drugs on the curative effect of femoral head replacement in the elderly patients with proximal humerus fracture.

Methods: From November 2012 to June 2016, 38 patients with proximal humeral fractures received humeral head replacement were divided into the treatment group and the control group according to whether the anti-osteoporosis drugs were used after the operation. The treatment group included 19 cases, of which 11 cases were three part fractures, 18 cases were four part fractures, and bone density was(0. Read More

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http://dx.doi.org/10.3969/j.issn.1003-0034.2019.02.008DOI Listing
February 2019

[Arteriosklerosis and "osteoporosis" in patients with chronic kidney disease: same same, but different!]

Ther Umsch 2018 ;75(6):371-375

1 Klinik für Nephrologie und Hypertonie, Universitätsspital Inselspital Bern.

Arteriosklerosis and "osteoporosis" in patients with chronic kidney disease: same same, but different! Abstract. Vascular calcifications should be considered a dynamic process sharing many similarities with bone formation. Even though the underlying pathophysiology of renal insufficiency-related vascular and bone disorders has just begun to be revealed, they appear to be closely related to each other and together appear to have an enormous impact on cardiovascular morbidity and mortality. Read More

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http://dx.doi.org/10.1024/0040-5930/a001011DOI Listing
January 2018

Impaired osseointegration of dental implants associated with orthognathic surgery: Possible regional acceleratory phenomenon.

Clin Implant Dent Relat Res 2019 Mar 18. Epub 2019 Mar 18.

Department of Oral and Maxillofacial Surgery, Ewha Womans University Medical Center, Seoul, South Korea.

Background: Regional acceleratory phenomenon (RAP) is demonstrated to decrease regional bone mineral density and accelerate bone turnover. Hypothesizing that RAP can negatively affect the osseointegration of biomaterials, this study aimed to investigate the possible influence of the RAP on dental implant osseointegration.

Materials And Methods: Orthognathic surgery, one of the major surgeries on oral and maxillofacial region was set as intervention for RAP. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cid.12745
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http://dx.doi.org/10.1111/cid.12745DOI Listing
March 2019
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Biofunctional soyasaponin Bb in peanut (Arachis hypogaea L.) sprouts enhances bone morphogenetic protein-2-dependent osteogenic differentiation via activation of runt-related transcription factor 2 in C2C12 cells.

Phytother Res 2019 Mar 18. Epub 2019 Mar 18.

Division of Crop Foundation, National Institute of Crop Science (NICS), Rural Development Administration (RDA), Wanju, Korea.

Improvement of bone formation is necessary for successful treatment of the bone defects associated with osteoporosis. In this study, we sought to elucidate the osteogenic activity of peanut sprouts and their bioactive components. We found that peanut sprout water extract (PSWE) enhanced bone morphogenetic protein-2-mediated osteoblast differentiation in a dose-dependent manner by stimulating expression of runt-related transcription factor 2 (Runx2) via activation of AKT/MAP kinases. Read More

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http://dx.doi.org/10.1002/ptr.6341DOI Listing

Association of SOST gene polymorphisms with peak bone mineral density in Chinese nuclear families with male-offspring.

Acta Biochim Biophys Sin (Shanghai) 2019 Mar;51(3):341-343

The Third Affiliated Hospital of Soochow University, Changzhou, China.

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http://dx.doi.org/10.1093/abbs/gmy175DOI Listing

The effects of high impact exercise intervention on bone mineral density, physical fitness, and quality of life in postmenopausal women with osteopenia: A retrospective cohort study.

Medicine (Baltimore) 2019 Mar;98(11):e14898

Department of Orthopaedic Surgery.

Osteoporosis and osteopenia prevailed in postmenopausal women and predisposed to osteoporotic fractures that increase mortality, morbidity, and the cost of social care. Here, we investigated the effect of 24 weeks of aerobic dancing on the bone miner density, physical fitness and health-related quality of life (HRQoL) in postmenopausal women with osteopenia. Total 80 participants (control [CON]: 40; exercise [EX]: 40) were included in the final analysis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014898DOI Listing

Mandibular Trabecular Bone Analysis Using Local Binary Pattern for Osteoporosis Diagnosis.

J Biomed Phys Eng 2019 Feb 1;9(1):81-88. Epub 2019 Feb 1.

Department of Computer Engineering, Science and IT, Shiraz University, Shiraz, Iran.

Background: Osteoporosis is a systemic skeletal disease characterized by low bone mineral density (BMD) and micro-architectural deterioration of bone tissue, leading to bone fragility and increased fracture risk. Since Panoramic image is a feasible and relatively routine imaging technique in dentistry; it could provide an opportunistic chance for screening osteoporosis. In this regard, numerous panoramic derived indices have been developed and suggested for osteoporosis screening. Read More

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February 2019

Bone Mineral Density, TBS, and Body Composition Indexes in Ukrainian Men with Parkinson's Disease.

Parkinsons Dis 2019 7;2019:9394514. Epub 2019 Feb 7.

SI "D. F. Chebotarev Institute of Gerontology NAMS of Ukraine", Department of Clinical Physiology & Pathology of Extrapiramide Nervous System, Kyiv, Ukraine.

Introduction: Current research studies demonstrate the changes of bone mineral density (BMD) in subjects with Parkinson's disease (PD); however, data about bone quality and body composition (BC) indexes are insufficient. The aim of the study was to assess the parameters of BMD, ВС, and trabecular bone score (TBS) in PD males.

Materials And Methods: We performed a cross-sectional case-control research design and examined 76 males aged 50-77 years old, who were divided into two groups: first group including men without PD (=38) and the second group including subjects with PD (=38). Read More

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http://dx.doi.org/10.1155/2019/9394514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383390PMC
February 2019

A Novel Heterozygous Mutation of the Gene Causes a Peculiar Phenotype without Hematuria and Renal Function Impairment in a Chinese Family.

Dis Markers 2019 10;2019:8705989. Epub 2019 Feb 10.

Department of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yishan Road, Xuhui District, 200233 Shanghai, China.

Mutations in the gene are frequently reported to be associated with various types of hereditary nephropathy. encodes the 3 chain of type IV collagen, which is the main structural protein in the basement membrane. Mutations in this gene are always related to kidney performance, and deafness and ocular lesion have also been reported. Read More

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http://dx.doi.org/10.1155/2019/8705989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387717PMC
February 2019

Monthly Intramuscular Neridronate for the Treatment of Postmenopausal Osteoporosis: Results of a 6-Year Prospective Italian Study.

Int J Endocrinol 2019 6;2019:9802827. Epub 2019 Feb 6.

CNR-Regione Toscana G Monasterio Foundation, Pisa, Italy.

Purpose: Oral bisphosphonates (BPs) are the most commonly used medications for osteoporosis (OP), but their poor gastrointestinal (GI) absorption and tolerance hamper compliance. Intramuscular (IM) neridronate (NE), an amino-BP, is an easy-to-administer, effective, and safe alternative to oral BPs. We assessed the 6-year effects of monthly IM NE on bone mineral density (BMD) and bone turnover biomarkers (BMs) in postmenopausal OP. Read More

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http://dx.doi.org/10.1155/2019/9802827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381585PMC
February 2019

Efficacy of denosumab therapy for a 21-year-old woman with Prader-Willi syndrome, osteoporosis and history of fractures: a case report.

Ther Clin Risk Manag 2019 25;15:303-307. Epub 2019 Feb 25.

Department of Orthopaedic Surgery, Shinshu University School of Medicine,

Appropriate management for osteoporosis in adult patients with Prader-Willi syndrome (PWS) has not been established. We report on a 21-year-old woman with PWS, who underwent denosumab treatment for osteoporosis. She presented with fractures and was shown to have very low bone mineral density (BMD), while she had been treated with supplementation of growth hormone for 7-14 years of age and estrogen from 15 years of age. Read More

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http://dx.doi.org/10.2147/TCRM.S186855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395054PMC
February 2019

Relationship between abnormal glucose metabolism and osteoporosis in Han Chinese men over the age of 50 years.

Clin Interv Aging 2019 25;14:445-451. Epub 2019 Feb 25.

Department of Elderly Endocrinology, Chinese PLA General Hospital, Haidian District, Beijing 100853, China,

Aim: The aim of this study was to determine the relationship between abnormal glucose metabolism and osteoporosis (OP) in Han Chinese men over the age of 50 years.

Patients And Methods: A cross-sectional study of 775 male patients aged over 50 years was performed at our hospital in 2011. The patients were divided into a normal glucose metabolism group, an impaired glucose regulation (IGR) group, and a type 2 diabetes mellitus (T2DM) group. Read More

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http://dx.doi.org/10.2147/CIA.S164021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394237PMC
February 2019

An Evaluation of the Association of Reproductive History and Multiple Births during Adolescence with Postmenopausal Osteoporosis.

Geburtshilfe Frauenheilkd 2019 Mar 11;79(3):300-307. Epub 2018 Oct 11.

Department of Physical Therapy and Rehabilitation, Duzce University Hospital, Duzce, Turkey.

Osteoporosis is the most common metabolic bone disease characterized by low bone mass. Reproductive factors are known to affect bone mineral density (BMD). Calcium loss from maternal bone and decreased BMD have been observed especially during pregnancy and lactation, although this loss has been reported to recover within 6 - 12 months. Read More

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http://dx.doi.org/10.1055/a-0743-7260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414300PMC

Assessment of the Relationship between Serum Vitamin D and Osteocalcin Levels with Metabolic Syndrome in Non-Osteoporotic Postmenopausal Women.

Geburtshilfe Frauenheilkd 2019 Mar 22;79(3):293-299. Epub 2019 Jan 22.

University of Health Sciences, Zekai Tahir Burak Women's Health Research and Education Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.

The aim of this study was to compare serum vitamin D and osteocalcin levels in non-osteoporotic postmenopausal women with and without metabolic syndrome and to analyze the relationship between serum vitamin D and osteocalcin levels and the relationships between these two factors and other clinical/biochemical parameters. This cross-sectional study was carried out in 191 postmenopausal non-osteoporotic (T-score > - 2.5) women. Read More

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http://dx.doi.org/10.1055/a-0767-6572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414302PMC

Raloxifene-encapsulated hyaluronic acid-decorated chitosan nanoparticles selectively induce apoptosis in lung cancer cells.

Bioorg Med Chem 2019 Mar 4. Epub 2019 Mar 4.

Department of Biochemistry, Faculty of Science, University of Tabuk, Saudi Arabia; Department of Chemistry, Biochemistry Specialty, Faculty of Science, Cairo University, Egypt. Electronic address:

Non-small cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC) are leading causes of cancer mortality and morbidity around the world. Despite the recent advances in their diagnosis and therapy, their prognosis remains poor owing to the development of drug resistance and metastasis. Raloxifene (RX), a drug first used in the treatment of osteoporosis, was recently approved for NSCLC and HCC prevention. Read More

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http://dx.doi.org/10.1016/j.bmc.2019.03.004DOI Listing
March 2019
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Treating osteoporosis: a near miss in an unusual case of FGF-23 mediated bone loss.

BMJ Case Rep 2019 Mar 16;12(3). Epub 2019 Mar 16.

Christian Medical College, Vellore, Tamil Nadu, India.

Oncogenic osteomalacia is a potentially curable condition caused by phosphaturic mesenchymal tumours. We present the case of 54-year-old woman who presented with bony pains and muscle weakness, and was erroneously treated with bisphosphonates elsewhere on the basis of Dual Energy X-ray Absorptiometry (bone density) scan that showed 'severe osteoporosis'. Further evaluation revealed the presence of hypophosphatemia, with a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid avid lesion involving left mandible on PET scan. Read More

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http://dx.doi.org/10.1136/bcr-2018-228375DOI Listing

Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases.

Biochem Pharmacol 2019 Mar 13. Epub 2019 Mar 13.

IRMB (Institut of Regenerative Medicine and Biotherapies), Inserm U1183, Univ Montpellier, Montpellier, France. Electronic address:

Over the past years, through in vitro studies and unique animal models, biologists and clinicians have demonstrated that cellular senescence is at the root of numerous age-related chronic diseases including osteoarthritis and osteoporosis. This non-proliferative cellular syndrome can modify other surrounding tissue-resident cells through the establishment of a deleterious catabolic and inflammatory microenvironment. Targeting these deleterious cells through local or systemic seno-therapeutic agent delivery in pre-clinical models improves dramatically clinical signs and extends health span. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.03.017DOI Listing
March 2019
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Functional characterization of the C7ORF76 genomic region, a prominent GWAS signal for osteoporosis in 7q21.3.

Bone 2019 Mar 13. Epub 2019 Mar 13.

Department of Genetics, Microbiology and Statistics, Facultat de Biologia, Universitat de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, IBUB, IRSJD, Barcelona, Catalonia, Spain. Electronic address:

Genome-wide association studies (GWAS) have repeatedly identified genetic variants associated with bone mineral density (BMD) and osteoporotic fracture in non-coding regions of C7ORF76, a poorly studied gene of unknown function. The aim of the present study was to elucidate the causality and molecular mechanisms underlying the association. We re-sequenced the genomic region in two extreme BMD groups from the BARCOS cohort of postmenopausal women to search for functionally relevant variants. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.014DOI Listing

The 2018 Guidelines for the diagnosis and treatment of osteoporosis in Greece.

Arch Osteoporos 2019 Mar 15;14(1):39. Epub 2019 Mar 15.

Hellenic Society for the Study of Bone Metabolism, Athens, Greece.

We report the updated guidelines for the management of osteoporosis in Greece, which include guidance on fracture risk assessment, diagnosis-pharmacological treatment-follow-up of osteoporosis based on updated information, and national evidence from Greek clinical practice and the healthcare setting.

Purpose: The purpose of this report was to update the Guidelines for the Management of Osteoporosis in Greece that was published in 2011.

Methods: In line with the GRADE system, the working group initially defined the main clinical questions that should be addressed when dealing with the diagnosis and management of osteoporosis in clinical practice in Greece. Read More

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http://dx.doi.org/10.1007/s11657-019-0584-3DOI Listing

Risk of institutionalization following fragility fractures in older people.

Osteoporos Int 2019 Mar 15. Epub 2019 Mar 15.

Department of Clinical Gerontology, Robert Bosch Krankenhaus Stuttgart, Auerbachstraße 110, 70376, Stuttgart, Germany.

Previously independent living older people suffering fractures of the hip have a high risk of new admission to a nursing home during the subsequent months. This study shows that older people admitted to hospital for fractures of the pelvis and spine have a similar risk of admission to a nursing home.

Introduction: Fall-related fractures are a serious threat to the health and well-being of older persons. Read More

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http://dx.doi.org/10.1007/s00198-019-04922-xDOI Listing
March 2019
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Performance of predictive tools to identify individuals at risk of non-traumatic fracture: a systematic review, meta-analysis, and meta-regression.

Osteoporos Int 2019 Mar 14. Epub 2019 Mar 14.

Bureau d'information et d'études en santé des populations, Institut National de Santé Publique du Québec, 945, Avenue Wolfe, Québec, G1V 5B3, Canada.

There is no consensus on which tool is the most accurate to assess fracture risk. The results of this systematic review suggest that QFracture, Fracture Risk Assessment Tool (FRAX) with BMD, and Garvan with BMD are the tools with the best discriminative ability. More studies assessing the comparative performance of current tools are needed. Read More

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http://link.springer.com/10.1007/s00198-019-04919-6
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http://dx.doi.org/10.1007/s00198-019-04919-6DOI Listing
March 2019
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Evaluation of the implementation of guidelines on the treatment of osteoporosis in patients with rheumatoid arthritis.

J Rheumatol 2019 Mar 15. Epub 2019 Mar 15.

From Clermont-Ferrand University Hospital, Rheumatology Department, 58 Rue Montalembert, Clermont-Ferrand, FR 63003; University Hospital Clermont-Ferrand, Biostatistics Unit (DRCI); Sorbonne Université, GRC-UPMC 08, Paris France; Pitié Salpêtrière hospital, APHP, Rheumatology department, Paris, France; Rheumatology Department, Cochin Hospital, AP-HP, Paris Descartes University, Paris, France; Clinical Epidemiology and Biostatistics, INSERM (U1153), PRES Sorbonne Paris-Cité, Paris, France. Address correspondence to Sandrine Malochet-Guinamand, Clermont-Ferrand University Hospital, Rheumatology Department, 58 Rue Montalembert, Clermont-Ferrand, FR 63003 Email:

Objective: To assess whether the 2003 and 2014 French guidelines on the prevention and treatment of glucocorticoid-induced osteoporosis (GIOP) and the 2012 updated of French guidelines for the treatment of postmenopausal osteoporosis (PMOP) were applied in patients with rheumatoid arthritis (RA).

Methods: We conducted a cross-sectionnal study of 776 RA patients (19 centers). We collected the data required for the application of the various recommendations (age, gender, prednisone intake, low energy fracture, history in the immediate family of hip fractures, and bone densitometry), anti-osteoporotic drugs and the various factors that may be associated with the application of the recommendations. Read More

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http://dx.doi.org/10.3899/jrheum.180889DOI Listing

Methoxsalen and Bergapten Prevent Diabetes-Induced Osteoporosis by the Suppression of Osteoclastogenic Gene Expression in Mice.

Int J Mol Sci 2019 Mar 14;20(6). Epub 2019 Mar 14.

Department of Food and Nutrition, Sunchon National University, Suncheon 57922, Korea.

This study evaluated whether bergapten and methoxsalen could prevent diabetes-induced osteoporosis and its underlying mechanism. For 10 weeks, bergapten or methoxsalen (0.02%, /) was applied to diabetic mice that were provided with a high-fat diet and streptozotocin. Read More

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http://dx.doi.org/10.3390/ijms20061298DOI Listing