J Biol Chem 2021 May 18:100790. Epub 2021 May 18.
Division of Bone and Mineral Research, Oral medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA; Department of Medicine, Harvard Medical School and Endocrine Unit, MGH, Boston, Massachusetts, USA. Electronic address:
Deletion of c-Src, a ubiquitously expressed tyrosine kinase, results in osteoclast dysfunction and osteopetrosis, in which bones harden into "stone". In contrast, deletion of the genes encoding other members of the Src family kinase (SFK) fails to produce an osteopetrotic phonotype. This suggests that c-Src performs a unique function in the osteoclast that cannot be compensated for by other Src family kinases. Read More