12,864 results match your criteria Osteopathic Medicine and Primary Care [Journal]


Interferon-α-induced retinopathy in chronic hepatitis C treatment: summary, considerations, and recommendations.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology and Vision Sciences, Princess Margaret Hospital/University Health Network, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.

Interferons are cytokines that regulate the host's response to viral infection, particularly in the setting of the immunologic response to the hepatitis C virus (HCV). While the virus has the ability to evade the host's innate and specific immunity, exogenous interferon-α with combined ribavirin, treatments have been found to achieve a significant sustained viral response in subgroups of patients with chronic HCV. One of the major side effects of interferon-α is an ocular retinopathy characterized by flame-shaped hemorrhages and cotton wool spots visualized on funduscopic examination. Read More

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December 2018

Optimal Scene Time to Achieve Favorable Outcomes in Out-of-hospital Cardiac Arrest: How Long Is Too Long?

Cureus 2018 Oct 9;10(10):e3434. Epub 2018 Oct 9.

Internal Medicine, Brookdale University Hospital Medical Center, New York, USA.

Background Despite advances in resuscitation science and public health, out-of-hospital cardiac arrest (OOHCA) cases have an average survival rate of only 12% nationwide, compared to 24.8% of cases occurring in hospital. Many factors, including resuscitation interventions, contribute to positive patient outcomes and have, therefore, been studied in attempts to optimize emergency medical services (EMS) protocols to achieve higher rates of return of spontaneous circulation (ROSC) in the field. Read More

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October 2018

Successful management of early gastrogastric fistula using fully covered esophageal stent.

Surg Obes Relat Dis 2018 Dec 26;14(12):1911-1913. Epub 2018 Sep 26.

Ultimate Bariatrics, Forth Worth, Texas.

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December 2018

Flightless birds are not neuroanatomical analogs of non-avian dinosaurs.

BMC Evol Biol 2018 Dec 13;18(1):190. Epub 2018 Dec 13.

Division of Paleontology, American Museum of Natural History, New York, NY, 10024, USA.

Background: In comparative neurobiology, major transitions in behavior are thought to be associated with proportional size changes in brain regions. Bird-line theropod dinosaurs underwent a drastic locomotory shift from terrestrial to volant forms, accompanied by a suite of well-documented postcranial adaptations. To elucidate the potential impact of this locomotor shift on neuroanatomy, we first tested for a correlation between loss of flight in extant birds and whether the brain morphology of these birds resembles that of their flightless, non-avian dinosaurian ancestors. Read More

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December 2018

The Impact of Protein Acetylation/Deacetylation on Systemic Lupus Erythematosus.

Int J Mol Sci 2018 Dec 12;19(12). Epub 2018 Dec 12.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA.

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease in which the body's immune system mistakenly attacks healthy cells. Although the exact cause of SLE has not been identified, it is clear that both genetics and environmental factors trigger the disease. Identical twins have a 24% chance of getting lupus disease if the other one is affected. Read More

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December 2018
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Incidence and Risk Factors for Posterior Cruciate Ligament Avulsion during Cruciate Retaining Total Knee Arthroplasty.

J Knee Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Orthopaedic Surgery, New England Baptist Hospital, Boston, Massachusetts.

During cruciate retaining (CR) total knee arthroplasty (TKA), the posterior cruciate ligament (PCL) may avulse at its insertion. The incidence of PCL avulsion fracture has not been previously studied. The aim of this study is to report on the incidence and clinical significance of intraoperative PCL avulsion during primary CR TKA and to identify potential risk factors. Read More

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December 2018

Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series.

J Altern Complement Med 2018 Dec 13. Epub 2018 Dec 13.

4 Department of Naturopathic Medicine, Wholeness Center , Fort Collins, CO.

Objectives: Cannabidiol (CBD) is a non-psychotomimetic cannabinoid compound that is found in plants of the genus Cannabis. Preclinical research has suggested that CBD may have a beneficial effect in rodent models of post-traumatic stress disorder (PTSD). This effect is believed to be due to the action of CBD on the endocannabinoid system. Read More

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December 2018

GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis.

Transl Neurodegener 2018 3;7:30. Epub 2018 Dec 3.

Genervon Biopharmaceuticals LLC, Pasadena, CA USA.

Background: Amyotrophic lateral sclerosis (ALS) is currently an incurable disease without highly effective pharmacological treatments. The peptide drug GM604 (GM6 or Alirinetide) was developed as a candidate ALS therapy, which has demonstrated safety and good drug-like properties with a favorable pharmacokinetic profile. GM6 is hypothesized to bolster neuron survival through the multi-target regulation of developmental pathways, but mechanisms of action are not fully understood. Read More

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December 2018

Comparison of PED and FRED Flow Diverters for Internal Carotid Artery Aneurysms: A Propensity Score-Matched Cohort Study.

Neurosurgery 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurology, Paracelsus Medical University, Salzburg, Austria.

Background: Flow diversion has become an accepted endovascular treatment modality for intracranial aneurysms. Studies comparing different types of flow diverters are currently lacking.

Objective: To perform a propensity score-matched cohort study comparing the Pipeline Embolization Device (PED; Medtronic, Dublin, Ireland) and Flow Redirection Endoluminal Device (FRED; MicroVention, Aliso Viejo, California). Read More

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December 2018
1 Read

Unforeseen consequence of alkaline water therapy for laryngopharyngeal reflux.

Ear Nose Throat J 2018 Dec;97(12):394-395

Department of Otolaryngology-Head and Neck Surgery, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA.

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December 2018
1 Read

Shoulder reflexes integrate elbow information at "long-latency" delay throughout a corrective action.

Authors:
Isaac L Kurtzer

J Neurophysiol 2018 Dec 12. Epub 2018 Dec 12.

Biomedical Sciences, New York Institute of Technology - College of Osteopathic Medicine, United States.

Previous studies have demonstrated a progression of function when healthy subjects counter a sudden mechanical load. Short-latency reflexes are linked to local stretch of the particular muscle and its antagonist. Long-latency reflexes integrate stretch information from both local sources and muscles crossing remote joints appropriate for limb's mechanical interactions. Read More

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December 2018

Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex.

Front Immunol 2018 27;9:2648. Epub 2018 Nov 27.

Department of Medicine, Center for Bioelectronic Medicine, Center for Molecular Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Macrophage cytokine production is regulated by neural signals, for example in the inflammatory reflex. Signals in the vagus and splenic nerves are relayed by choline acetyltransferase T cells that release acetylcholine, the cognate ligand for alpha7 nicotinic acetylcholine subunit-containing receptors (α7nAChR), and suppress TNF release in macrophages. Here, we observed that electrical vagus nerve stimulation with a duration of 0. Read More

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November 2018
1 Read

Early detection of metabolic dysregulation using water T analysis of biobanked samples.

Diabetes Metab Syndr Obes 2018 23;11:807-818. Epub 2018 Nov 23.

Nanoparticle Diagnostics Laboratory, Institute for Cardiovascular and Metabolic Diseases, Department of Physiology & Anatomy, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA,

Background: The ability to use frozen biobanked samples from cohort studies and clinical trials is critically important for biomarker discovery and validation. Here we investigated whether plasma and serum water transverse relaxation times (T) from frozen biobanked samples could be used as biomarkers for metabolic syndrome (MetS) and its underlying conditions, specifically insulin resistance, dyslipidemia, and subclinical inflammation.

Methods: Plasma and serum aliquots from 44 asymptomatic, non-diabetic human subjects were biobanked at -80°C for 7-9 months. Read More

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November 2018

Hypoglycemia secondary to factitious hyperinsulinism in a foster care adolescent - a case report of munchausen syndrome in a community hospital emergency department setting.

BMC Emerg Med 2018 Dec 11;18(1):53. Epub 2018 Dec 11.

Northeast Georgia Medical Center Barrow, 316 N Broad St, Winder, GA, 30680, USA.

Background: Factitious disorder causing hypoglycemia is a psychiatric condition in which patients deliberately use blood sugar lowering medications to cause severe symptoms for the purposes of hospitalization or other primary gains.

Case Presentation: We report a case of factitious hypoglycemia in a 19-year-old foster care adolescent female who presented to the Emergency Department with recurrent hypoglycemic episodes, to the degree that the patient required large amounts of dextrose and further management by intensive care unit hospitalization. Further inquiry revealed that the patient intentionally injected herself with large doses of insulin for the purposes of seeking hospital admission. Read More

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December 2018

Association between interleukin‑33 and ovarian cancer.

Oncol Rep 2018 Dec 7. Epub 2018 Dec 7.

Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA.

Ovarian cancer is the leading cause of cancer‑ associated mortality in the female reproductive system. Interleukin (IL)‑33 and its receptor IL 1 receptor like 1 (also termed ST2) are expressed by many cell types including epithelial cells. The role of IL‑33 in the pathogenesis of neoplasia remains controversial. Read More

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December 2018

Potential Harms of HIPAA.

JAMA 2018 12;320(22):2378-2379

University of the Incarnate Word School of Osteopathic Medicine, San Antonio, Texas.

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December 2018

Effect of Osteopathic Visceral Manipulation on Pain, Cervical Range of Motion, and Upper Trapezius Muscle Activity in Patients with Chronic Nonspecific Neck Pain and Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.

Evid Based Complement Alternat Med 2018 11;2018:4929271. Epub 2018 Nov 11.

Postgraduate Program in Rehabilitation Sciences, Physical Therapy Departament, Universidade Nove de Julho, UNINOVE, Brazil.

Previous studies have reported that visceral disturbances can lead to increased musculoskeletal tension and pain in structures innervated from the corresponding spinal level through viscerosomatic reflexes. We designed a pilot randomised placebo-controlled study using placebo visceral manipulation as the control to evaluate the effect of osteopathic visceral manipulation (OVM) of the stomach and liver on pain, cervical mobility, and electromyographic activity of the upper trapezius (UT) muscle in individuals with nonspecific neck pain (NS-NP) and functional dyspepsia. Twenty-eight NS-NP patients were randomly assigned into two groups: treated with OVM (OVMG; = 14) and treated with placebo visceral manipulation (PVMG; = 14). Read More

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November 2018

Arthroscopic Treatment of Popliteal Cysts.

Arthrosc Tech 2018 Nov 8;7(11):e1109-e1114. Epub 2018 Oct 8.

Division of Sports Medicine, Michigan State University, East Lansing, Michigan, U.S.A.

Popliteal cysts, often referred to as Baker's cysts, are a common occurrence in the adult knee. Although controversy exists as to the exact indications for treatment, these structures can cause extreme discomfort and morbidity, including pain from rupture and symptoms from neurovascular compromise. Prior to the development of the arthroscope, open treatment of popliteal cysts was not uncommon. Read More

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November 2018
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Mycobacterium tuberculosis Infection in the Setting of Interstitial Lung Disease: Coincidence or Bad Luck?

Cureus 2018 Oct 1;10(10):e3391. Epub 2018 Oct 1.

Pulmonology, New York Presbyterian Hospital Queens, New York, USA.

Mycobacterium tuberculosis (MTB) infection is the ninth leading cause of death worldwide, with many individuals with undiagnosed active or latent disease. The presence of parenchymal lung disease, such as interstitial lung disease (ILD), has been suggested to increase the risk of pulmonary tuberculosis (TB). In the clinical setting of ILD, the diagnosis of an underlying MTB infection may be challenging due to the interstitial process and underlying fibrosis, which may mask the infection. Read More

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October 2018
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Response to Pazopanib in Patients With Relapsed Osteosarcoma.

J Pediatr Hematol Oncol 2018 Dec 7. Epub 2018 Dec 7.

Cook Children's Medical Center, Fort Worth, TX.

Axial skeleton primary tumor, metastatic disease at presentation, incomplete surgical resection, and <90% tumor necrosis have all been known to influence prognosis adversely in osteosarcoma. Relapse of osteosarcoma, typically occurring within the first 18 months of therapy, with an incidence rate of 50% is treated with surgery, chemotherapy, and targeted therapy. Here, we discuss 2 patients treated with pazopanib, a multi-tyrosine kinase inhibitor presently approved to treat renal cell carcinoma and soft tissue sarcomas. Read More

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December 2018

Treatment of Closed Femoral Shaft Fractures in Children Aged 6 to 10.

J Pediatr Orthop 2018 Dec 8. Epub 2018 Dec 8.

Department of Orthopaedic Surgery, St. Christopher's Hospital for Children, Philadelphia, PA.

Background: Management of pediatric femoral shaft fractures remains controversial, particularly in children between the ages of 6 and 10. In the current push toward cost containment, hospital type, and surgeon subspecialization have emerged as important factors influencing this treatment decision. Thus, in the present study, we use a nationwide pediatric inpatient database to compare the: (a) incidence; (b) demographic characteristics; (c) hospital costs; (d) length of stay; and (e) treatment method of pediatric closed femoral shaft fractures admitted to general versus children's hospitals. Read More

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December 2018

SLAMF7 Is a Critical Negative Regulator of IFN-α-Mediated CXCL10 Production in Chronic HIV Infection.

J Immunol 2018 Dec 10. Epub 2018 Dec 10.

Department of Microbiology and Molecular Genetics, College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824;

Current advances in combined antiretroviral therapy have rendered HIV infection a chronic, manageable disease; however, the problem of persistent immune activation still remains despite treatment. The immune cell receptor SLAMF7 has been shown to be upregulated in diseases characterized by chronic immune activation. In this study, we studied the function of the SLAMF7 receptor in immune cells of HIV patients and the impacts of SLAMF7 signaling on peripheral immune activation. Read More

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December 2018

Developmental and functional heterogeneity of white adipocytes within a single fat depot.

EMBO J 2018 Dec 10. Epub 2018 Dec 10.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA

Recent studies suggest that, even within a single adipose depot, there may be distinct subpopulations of adipocytes. To investigate this cellular heterogeneity, we have developed multiple conditionally immortalized clonal preadipocyte lines from white adipose tissue of mice. Analysis of these clones reveals at least three white adipocyte subpopulations. Read More

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December 2018

Extralobar Sequestration Complicated by a Cystic Hamartoma in an Adult.

Ann Thorac Surg 2018 Dec 7. Epub 2018 Dec 7.

Department Pulmonary and Critical Care Medicine, Lankenau Medical Center. 100 Lancaster Avenue, Wynnewood, PA 19096. Electronic address:

A 49 year old female presented after a respiratory infection with a abnormal chest X-ray demonstrating a cystic calcified mass at the base of the right lung. Chest CT angiogram demonstrated the blood supply arose from the abdominal aorta. This Extralobar sequestration was surgically resected via Video assisted thoracoscopy without complication. Read More

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December 2018

Challenges in Treatment for Fever among School-Age Children and Adults in Malawi.

Am J Trop Med Hyg 2018 Dec 10. Epub 2018 Dec 10.

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland.

Prompt and effective treatment is key to malaria control and prevention, as it reduces disease morbidity and mortality and minimizes the number of transmission reservoirs. Transmission reduction may be particularly important among school-age children (SAC, 5-15 years old), who have the highest prevalence of infection in southern Malawi. We hypothesized that one factor contributing to this difference in prevalence is that SAC are less likely to seek appropriate treatment for fever than children younger than 5 years. Read More

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December 2018

Attitudes, skills and use of evidence-based practice among UK osteopaths: a national cross-sectional survey.

BMC Musculoskelet Disord 2018 Dec 8;19(1):439. Epub 2018 Dec 8.

Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia.

Background: Evidence-based practice (EBP) is a clinical decision-making framework that supports quality improvement in healthcare. While osteopaths are key providers of musculoskeletal healthcare, the extent to which osteopaths engage in EBP is unclear. Thus, the aim of this cross-sectional study was to investigate UK osteopaths' attitudes, skills and use of EBP, and perceived barriers and facilitators of EBP uptake. Read More

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December 2018

The effect of unilateral lingual nerve injury on the kinematics of mastication in pigs.

Arch Oral Biol 2018 Nov 22;98:226-237. Epub 2018 Nov 22.

Ohio University Heritage College of Osteopathic Medicine, Department of Biomedical Sciences, Irvine Hall 228, Athens, OH, 45701, USA. Electronic address:

Objective: This study evaluates the effect of unilateral lingual sensory loss on the spatial and temporal dynamics of jaw movements during pig chewing.

Design: X-ray Reconstruction of Moving Morphology (XROMM) was used to reconstruct the 3-dimensional jaw movements of 6 pigs during chewing before and after complete unilateral lingual nerve transection. The effect of the transection were evaluated at the temporal and spatial level using Multiple Analysis of Variance. Read More

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November 2018
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Diagnosis and Management of Fungal Periprosthetic Joint Infections.

J Am Acad Orthop Surg 2018 Dec 4. Epub 2018 Dec 4.

From the Sinai Hospital of Baltimore, Baltimore, MD (Dr. Nace), the Philadelphia College of Osteopathic Medicine, Philadelphia, PA (Dr. Siddiqi), the New England Baptist Hospital, Boston, MA (Dr. Talmo), and the Brigham and Women's Hospital, Boston, MA (Dr. Chen).

Fungal periprosthetic joint infection (PJI) is a devastating complication because it can be difficult to diagnose, manage, and eradicate. Fungal PJI treatment requires a systematic approach. Increased awareness is essential when patients with painful arthroplasties present with immunosuppression, significant comorbidities, multiple surgeries, and history of drug use. Read More

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December 2018
3 Reads

An interdisciplinary review of the thanatomicrobiome in human decomposition.

Forensic Sci Med Pathol 2018 Dec 5. Epub 2018 Dec 5.

Department of Biological Sciences, Florida International University, Miami, FL, USA.

Death does not occur instantaneously and organs do not decompose at the same rate or in the same way. Nulligravid human uteri and prostate glands are the last internal organs to deteriorate during decomposition; however, the reason for this very important observation is still enigmatic. Recent studies have elucidated that the composition and abundance of microbes in the human thanatomicrobiome (microbiome of death) varies by organ and changes as a function of time and temperature. Read More

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December 2018
4 Reads

Use of Social Psychology to Improve Adherence to National Bronchiolitis Guidelines.

Pediatrics 2018 Dec 5. Epub 2018 Dec 5.

Division of General Pediatrics, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.

Objectives: The American Academy of Pediatrics' bronchiolitis guidelines recommend against albuterol and corticosteroids for treating and chest radiographs (CRs) for diagnosing infants with bronchiolitis. However, high rates of nonadherence have been documented. Our objective was to improve guideline adherence in infants with bronchiolitis. Read More

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December 2018
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Development of a collaborative model of low back pain: report from the 2017 NASS consensus meeting.

Spine J 2018 Nov 30. Epub 2018 Nov 30.

NHMRC Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, School of Health and Rehabilitation Sciences, University of Queensland, Queensland, Australia.

Background Context: Low back pain (LBP) is a multifactorial problem with complex interactions among many biological, psychological and social factors. It is difficult to fully appreciate this complexity because the knowledge necessary to do so is distributed over many areas of expertise that span the biopsychosocial domains.

Purpose: This study describes the collaborative modeling process, undertaken among a group of participants with diverse expertise in LBP, to build a model to enhance understanding and communicate the complexity of the LBP problem. Read More

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November 2018
4 Reads

Western diet triggers Toll-like receptor 4 signaling-induced endothelial dysfunction in female Wistar rats.

Am J Physiol Heart Circ Physiol 2018 Dec 28;315(6):H1735-H1747. Epub 2018 Sep 28.

Department of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, New York.

Overconsumption of a diet rich in fat and carbohydrates, called the Western diet, is a major contributor to the global epidemic of cardiovascular disease. Despite previously documented cardiovascular protection exhibited in female rats, this safeguard may be lost under certain metabolic stressors. We hypothesized that female Wistar rats challenged by a Western diet composed of 21% fat and 50% carbohydrate (34. Read More

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December 2018
2 Reads

Are endocasts good proxies for brain size and shape in archosaurs throughout ontogeny?

J Anat 2018 Dec 3. Epub 2018 Dec 3.

Division of Paleontology, American Museum of Natural History, New York, NY, USA.

Cranial endocasts, or the internal molds of the braincase, are a crucial correlate for investigating the neuroanatomy of extinct vertebrates and tracking brain evolution through deep time. Nevertheless, the validity of such studies pivots on the reliability of endocasts as a proxy for brain morphology. Here, we employ micro-computed tomography imaging, including diffusible iodine-based contrast-enhanced CT, and a three-dimensional geometric morphometric framework to examine both size and shape differences between brains and endocasts of two exemplar archosaur taxa - the American alligator (Alligator mississippiensis) and the domestic chicken (Gallus gallus). Read More

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December 2018

IL-39 acts as a friend to pancreatic cancer.

Med Oncol 2018 Dec 1;36(1):12. Epub 2018 Dec 1.

Department of Microbiology & Immunology, Des Moines University College of Osteopathic Medicine, Des Moines, IA, 50312, USA.

Pancreatic cancer is the most lethal digestive cancer and the fourth leading cause of cancer death in the US. IL-39, a heterodimer of p19 and EBI3, is a newly found cytokine and its role in the pathogenesis of neoplasia has not been studied yet. This study was designed to investigate the direct role of IL-39 in the growth of pancreatic cancer. Read More

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December 2018

Novel Survivin Inhibitor for Suppressing Pancreatic Cancer Cells Growth via Downregulating Sp1 and Sp3 Transcription Factors.

Cell Physiol Biochem 2018 30;51(4):1894-1907. Epub 2018 Nov 30.

Graduate School of Biomedical Sciences, UNT Health Science Center, Fort Worth, Texas,

Background/aims: Targeting survivin, an anti-apoptotic protein and mitotic regulator, is considered as an effective therapeutic option for pancreatic cancer (PaCa). Tolfenamic acid (TA) showed anti-cancer activity in pre-clinical studies. A recent discovery demonstrated a copper(II) complex of TA (Cu-TA) can result in higher activity. Read More

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November 2018

Special issue: Current Vision on Target Enzymes for Cancer Therapy.

Semin Cancer Biol 2018 Nov 29. Epub 2018 Nov 29.

King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia; Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770, Australia; Novel Global Community Educational Foundation, Australia. Electronic address:

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November 2018

Step width and frontal plane trunk motion in bipedal chimpanzee and human walking.

J Hum Evol 2018 Dec 16;125:27-37. Epub 2018 Oct 16.

Department of Anatomical Sciences, Stony Brook University Medicine, Stony Brook, NY 11794, USA.

Human bipedalism is characterized by mediolateral oscillations of the center of mass (CoM) between the feet. The preferred step widths and CoM oscillations used by humans likely represent a trade-off of several factors (e.g. Read More

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December 2018

Great ape thorax and shoulder configuration-An adaptation for arboreality or knuckle-walking?

J Hum Evol 2018 Dec 16;125:15-26. Epub 2018 Oct 16.

Department of Anatomical Sciences, Stony Brook University School of Medicine, Stony Brook, NY 11794-8081, USA.

Great apes exhibit a suite of morphological traits of the shoulder and upper thorax that have traditionally been linked to orthograde arborealism. Recently it has been proposed that these traits are instead adaptations for knuckle-walking, and more broadly, that knuckle-walking itself is an adaptation for shock absorption during terrestriality. Here we test several tenets of these hypotheses using kinematic and kinetic data from chimpanzees and macaques, and electromyographic data of shoulder muscle activity in chimpanzees. Read More

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December 2018
2 Reads

Afamelanotide in the Treatment of Dermatologic Disease

Skin Therapy Lett 2018 11;23(6):6-10

Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA

Afamelanotide, an α-melanocyte stimulating hormone analogue, has become an emerging therapeutic option for a variety of skin conditions previously refractory to other treatments. Its efficacy has been demonstrated in several dermatologic conditions, including erythropoietic protoporphyria (EPP), solar urticaria, polymorphic light eruption (PMLE), vitiligo, acne, and Hailey-Hailey disease. Its relatively low risk side effect profile makes it an attractive treatment option and also paves the way for innovative use in other disorders. Read More

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November 2018
3 Reads

Malaria Modeling to Evaluate Treatment for Severe Disease.

J Infect Dis 2018 Dec 5. Epub 2018 Dec 5.

Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing.

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December 2018

Cyclin C directly stimulates Drp1 GTP affinity to mediate stress-induced mitochondrial hyper-fission.

Mol Biol Cell 2018 Dec 5:mbcE18070463. Epub 2018 Dec 5.

Graduate School of Biomedical Sciences, Department of Molecular Biology, Rowan University School of Osteopathic Medicine, Two Medical Center Drive, Stratford, NJ 08084 USA.

Mitochondria exist in an equilibrium between fragmented and fused that shifts heavily toward fission in response to cellular damage. Nuclear to cytoplasmic cyclin C relocalization is essential for dynamin-related protein 1 (Drp1)-dependent mitochondrial fission in response to oxidative stress. This study finds that cyclin C directly interacts with the Drp1 GTPase domain, increases its affinity to GTP and stimulates GTPase activity in vitro. Read More

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December 2018

On the median pharyngeal valve of the American alligator (Alligator mississippiensis).

J Morphol 2018 Dec 5. Epub 2018 Dec 5.

Department of Biology, University of Maryland, College Park, Maryland.

The middle ear cavities of crocodilians have complex connections with the pharyngeal lumen, including lateral and median components which both open into a single chamber located on the dorsal midline of the pharynx. This chamber and the surrounding soft-tissue is herein termed the median pharyngeal valve. In the American alligator (Alligator mississippiensis) this valve opens, for a duration of 0. Read More

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December 2018
4 Reads

Palmitic acid methyl ester is a novel neuroprotective agent against cardiac arrest.

Prostaglandins Leukot Essent Fatty Acids 2018 Nov 23. Epub 2018 Nov 23.

Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, USA; Center for Brain Health, Louisiana State University Health Sciences Center, Shreveport, LA, USA; Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, USA; Cardiovascular and Metabolomics Research Center, Hualien Tzu Chi Hospital, Taiwan; Department of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan. Electronic address:

We previously discovered that palmitic acid methyl ester (PAME) is a potent vasodilator first identified and released from the superior cervical ganglion and remain understudied. Thus, we investigated PAME's role in modulating cerebral blood flow (CBF) and neuroprotection after 6 min of cardiac arrest (model of global cerebral ischemia). Our results suggest that PAME can enhance CBF under normal physiological conditions, while administration of PAME (0. Read More

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November 2018
3 Reads

Moving toward Narrative Competence and Inclusive Healthcare through the Open Book Project.

Health Commun 2018 Dec 4:1-5. Epub 2018 Dec 4.

h Office of Inclusion , Ohio University Heritage College of Osteopathic Medicine Ohio University.

This essay offers a layered account of the origins and enactment of a narrative medicine program at the Ohio University Heritage College of Osteopathic Medicine titled the Open Book Project (OBP). Narrative medicine positions clinical judgment as involving both scientific and narrative reasoning, a set of practices particularly well-suited to fostering inclusive health care and social justice. The OBP involved first-year medical students who met bi-monthly to witness, reflect on, and write about literary passages, visual images, music and lyrics, and other works of art. Read More

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December 2018

Magnesium: Are We Consuming Enough?

Nutrients 2018 Dec 2;10(12). Epub 2018 Dec 2.

Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA 16509, USA.

Magnesium is essential for maintaining normal cellular and organ function. In-adequate magnesium balance is associated with various disorders, such as skeletal deformities, cardiovascular diseases, and metabolic syndrome. Unfortunately, routinely measured serum magnesium levels do not always reflect total body magnesium status. Read More

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December 2018
1 Read

A Misguided Venture: Presidential Fitness and the Duty to Warn.

South Med J 2018 Dec;111(12):767-769

From the Air Force Judge Advocate General's Corps and the University of the Incarnate Word School of Osteopathic Medicine, San Antonio, Texas.

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December 2018