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Nihon Shokakibyo Gakkai Zasshi 2022 ;119(8):761-767

Department of Hepatology, Aso Iizuka Hospital.

A 61-year-old man was admitted due to alcoholic liver cirrhosis, portal vein thrombosis, hepatocellular carcinoma, and chronic pancreatitis. The patient's portal vein thrombosis improved with anticoagulant therapy. Serum amylase gradually increased, but there was no abdominal pain. Read More

Medicine (Baltimore) 2022 Jul 29;101(30):e29585. Epub 2022 Jul 29.

Department of Orthopedics, National Cheng Kung University Hospital, Tainan City, Taiwan.

Spontaneous osteonecrosis of the knee (SONK) causes knee pain and joint motion limitation. Ischemia or insufficiency fracture may be the cause, but no consensus has been developed. Proximal fibular osteotomy (PFO) has been reported to relieve pain from osteoarthritis through medial compartment decompression. Read More

Zhonghua Wai Ke Za Zhi 2022 Jul;60(7):703-708

Department of Orthopedics,the Affiliated Hospital of Qingdao University,Qingdao 266000,China.

To investigate the long-term outcomes of minimally invasive Oxford phase Ⅲ unicompartmental knee arthroplasty (UKA) for patients with medial compartment osteoarthropathy. The clinical data of 594 patients (701 knees) who underwent minimally invasive UKA with Oxford phase Ⅲ unicompartmental prosthesis at Department of Orthopedics,the Affiliated Hospital of Qingdao University from January 2007 to January 2016 were retrospectively analyzed.There were 155 males and 439 females,aged (62. Read More

Orthop Rev (Pavia) 2022 25;14(3):33639. Epub 2022 Apr 25.

Medical direction, San Pier Damiano Hospiatl, GVM care and research, Faenza (RA), Italy.

Knee osteonecrosis is a debilitating progressive degenerative disease characterized by subchondral bone ischemia. It can lead to localized necrosis, tissue death, and progressive joint destruction. For this reason, it is essential to diagnose and treat this disease early to avoid subchondral collapse, chondral damage, and end-stage osteoarthritis, where the only solution is total knee arthroplasty. Read More

Healthcare (Basel) 2022 Jun 8;10(6). Epub 2022 Jun 8.

Department of Morphological Sciences, Carol Davila University of Medicine and Pharmacy, RO-020021 Bucharest, Romania.

Osteochondral lesions (OCLs) that are frequently encountered in skeletally immature and adult patients are more common than once thought, and their incidence rate is rising. These lesions can appear in many synovial joints of the body, such as the shoulder, elbow, hip, and ankle, occurring most often in the knee. The term osteochondral lesion includes a vast spectrum of pathologies such as osteochondritis dissecans, osteochondral defects, osteochondral fractures, and osteonecrosis of the subchondral bone. Read More

J Surg Case Rep 2022 Jun 10;2022(6):rjac223. Epub 2022 Jun 10.

Orthopaedic Surgery and Traumatology Department, Hospital Universitario La Paz, Universidad Autónoma de Madrid, P° Castellana 261, 28046 Madrid, Spain.

Due to advances in retroviral treatment, human immunodeficiency virus (HIV)-related disease may become chronic and the patient survival has substantially increased. Osteoarticular disease in those patients include multifocal osteonecrosis and its complications. Pain and functional limitation may be due to these complications, frequently underdiagnosed, including pathological fractures. Read More

Clin Nucl Med 2022 Jun 10. Epub 2022 Jun 10.

From the Departments of Nuclear Medicine.

Abstract: Spontaneous osteonecrosis of the knee (SONK) is the most common phenotype of osteonecrosis of knee joints in older adults. Early diagnosis with appropriate management is crucial for improving the prognosis of the SONK. We present SONK in bone scintigraphy and SPECT/CT in 65-year-old man with sudden worsening knee pain and normal radiographs. Read More

Clin Biomech (Bristol, Avon) 2022 Jul 20;97:105670. Epub 2022 May 20.

University of Duisburg-Essen, Engineering Faculty, Chair of Mechanics and Robotics, Lotharstr. 1, D-47057 Duisburg, Germany.

Background: Until now follow-up- and outcome evaluations in Perthes disease are analysing predominantly subjective results and clinical/radiological parameters. To enlarge the assessment by quantitative, functional aspects a summary measure for overall gait quality would be helpful. Therefore, the objective of this study is to evaluate whether commonly used global gait indices are sensitive to detect gait deviations during the early stages of the Perthes disease. Read More

J Vasc Interv Radiol 2022 Jun 2. Epub 2022 Jun 2.

Division of Vascular and Interventional Radiology, Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia.

Purpose: To create a nonsurgical animal model of osteoarthritis (OA) to evaluate the effects of embolotherapy during geniculate artery embolization (GAE).

Materials And Methods: Fluoroscopy-guided injections of 700 mg of sodium monoiodoacetate were performed into the left stifle in 6 rams. Kinematic data were collected before and after induction. Read More

Radiology 2022 Aug 10;304(2):363-369. Epub 2022 May 10.

From the Department of Radiology, Balgrist University Hospital, Forchstrasse 340, 8008 Zurich, Switzerland, and the Faculty of Medicine, University of Zurich, Zurich, Switzerland.

Background Intraarticular corticosteroid (IACS) injections are frequently performed for hip and knee osteoarthritis (OA); however, there are conflicting data about the benefits and complications of IACS injections and a lack of large studies with follow-up. Purpose To determine the number of patients with complications after hip and knee IACS injections in a large study sample with long-term follow-up. Materials and Methods This retrospective single-center case series included patients who received a corticosteroid injection in the hip ( = 500) or knee ( = 500) and who underwent clinical and radiologic follow-up (conventional radiography, fluoroscopy, CT, or MRI) between 1 and 12 months after injection (January 2016 to May 2020). Read More

Knee 2022 Jun 6;36:72-79. Epub 2022 May 6.

Department of Orthopaedic Surgery, Yokohama City University, Japan.

Purpose: Spontaneous osteonecrosis of the knee (SONK) causes acute atraumatic knee pain, and meniscus tears may be associated with the pathogenesis of SONK. The purpose of this study was to investigate the relationship of the type of meniscus tear and medial meniscus extrusion with SONK on the medial femoral condyle in patients who underwent surgical treatment with high tibial osteotomy due to severe knee pain.

Methods: We enrolled 98 patients with 102 knees who underwent medial opening wedge high tibial osteotomy (OWHTO) under the diagnosis of medial femoral condyle osteonecrosis at our hospital from December 2003 to January 2020. Read More

Int J Pharm 2022 Jun 5;622:121802. Epub 2022 May 5.

School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, Jiangsu, China. Electronic address:

The combination of corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs) has been commonly used for inflammation and chronic articular pain in the clinic. Nonetheless, the long-term administration of both medications might result in osteonecrosis of the knee due to repeated injections of steroids and side effects in the gastrointestinal and cardiovascular systems. To overcome these unmet medical needs, we designed a microsphere-microcrystal-gel delivery system for intra-articular injection. Read More

Malays Orthop J 2022 Mar;16(1):76-83

Department of Orthopaedics, Dr. Goyal Bone and Joint Clinic, New Delhi, India.

Introduction: Post-operative pain following anterior cruciate ligament reconstruction remains an important challenge. Steroids are used in various surgical procedures to decrease post-operative nausea, vomiting and pain. However, only a few studies have reported the effect of systemic administration of steroids in controlling postoperative pain after anterior cruciate ligament surgery. Read More

Front Med (Lausanne) 2022 11;9:847875. Epub 2022 Apr 11.

Department of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Objective: To explore risk factors for developing osteonecrosis in patients with systemic lupus erythematosus (SLE).

Methods: Twenty-six SLE patients with osteonecrosis from January 2018 to December 2019 were described. Fifty SLE patients without osteonecrosis were selected as controls from the SLE database (total 2,680) of our hospital during the same period. Read More

Front Surg 2022 8;9:662722. Epub 2022 Apr 8.

Sports Medicine Institute, Hospital for Special Surgery, New York, NY, United States.

Osteonecrosis of the femoral head (ONFH) is caused when circulation within the femoral head is disrupted. Etiology of this disease is characterized by either traumatic events or atraumatic risk factors, such as chronic alcohol consumption or glucocorticoid use. ONFH commonly presents as pain in the groin, gluteus muscles, and/or knee with reductions in internal rotation range of motion of the hip. Read More

Int J Infect Dis 2022 Aug 21;121:11-13. Epub 2022 Apr 21.

Department of Orthopaedic Surgery & Musculoskeletal Trauma, Faculty of Medicine, University of Thessaly, Larissa, Greece.

Recovery from COVID-19 is not always uneventful, especially in critically ill hospitalized patients. Persistent symptoms including fatigue/ weakness, shortness of breath, anxiety, and depression have been described at one-year follow-up. Furthermore, symptoms from the musculoskeletal system like joint pain or stiffness are underreported in studies with long-term follow-up of up to one year. Read More

Mod Rheumatol Case Rep 2022 Apr 23. Epub 2022 Apr 23.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

To our knowledge, only one previous report described the treatment of osteochondral autograft for steroid-induced osteonecrosis of the humeral head (ONHH) in a middle-aged patient. The present report describes a 20-year-old man who was found to have avascular osteonecrosis of the right humeral head after corticosteroid pulse treatment, followed by oral corticosteroid therapy. The patient complained of serious right shoulder pain and limited range of motion (ROM). Read More

Eur J Radiol 2022 Jun 9;151:110308. Epub 2022 Apr 9.

Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Japan.

Purpose: To evaluate the recently developed three-dimensional (3D) T1ρ-mapping technique for the quantitative evaluation of cartilage changes after open-wedge high tibial osteotomy (OWHTO).

Method: Eleven patients with medial knee osteoarthritis and spontaneous osteonecrosis of the medial femoral condyle underwent T1ρ magnetic resonance imaging. The full-thickness cartilage of the medial femoral condyle (MFC), lateral femoral condyle, medial tibial condyle, and lateral tibial condyle, and the trochlea and patella were set as regions of interest; mean T1ρ values were calculated using two-dimensional (2D) and 3D analyses. Read More

Sci Rep 2022 04 13;12(1):6182. Epub 2022 Apr 13.

Clinical Biomechanics of Andalucia Laboratory, University of Malaga, Malaga, Spain.

Treatment of posterior meniscal roots tears evolved after biomechanical evidence of increased pressures on the tibiofemoral cartilage produced by this lesion and the subsequent accelerated development of arthritis or osteonecrosis observed clinically. However, little is known about the consequences of the detachment of the anterior roots. This in-vitro study analyzes the biomechanical changes in the tibiofemoral joint caused by avulsion of the anterior root of the lateral meniscus. Read More

J Arthroplasty 2022 Apr 6. Epub 2022 Apr 6.

Orthopaedics Surgery and Sports Medicine Department, FIFA Medical Center of Excellence, Croix-Rousse Hospital, Lyon University Hospital, Lyon, France; University Lyon, Claude Bernard Lyon 1 University, IFSTTAR, Lyon, France.

Background: While good mid-term results for treating spontaneous knee osteonecrosis (SPONK) with unicompartmental knee arthroplasty (UKA) have been reported, concerns remain about implant survival at long-term. This study aimed to compare outcomes and survivorship of UKA for SPONK vs osteoarthritis at a minimum of 10 years.

Methods: This case-control study included medial UKA for femoral SPONK operated between 1996 and 2010 with a minimum 10-year follow-up (n = 47). Read More

Clin Rheumatol 2022 Aug 7;41(8):2491-2498. Epub 2022 Apr 7.

Department of Medical Informatics and Biostatistics, "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania.

Background: For knee OA, EULAR has included hyaluronic acid (HA) intra-articular injection in the 2003 recommendations, making the intra-articular injection a sound therapeutic option. The ultrasound-guided intra-articular injections (USGIAI) have been demonstrated to be more efficient and safe in comparison to the blind procedure. Our objectives were to evaluate the short- and medium-term efficacy and safety of USGIAI of HA in moderate hip OA and patients' additional NSAIDs/pain killer intake. Read More

Cureus 2022 Mar 1;14(3):e22735. Epub 2022 Mar 1.

Rheumatology, Einstein Medical Center Philadelphia, Philadelphia, USA.

Corticosteroid therapy is a known risk factor for osteonecrosis, more commonly with chronic use and high cumulative dose. Osteonecrosis (avascular necrosis) has been described in pregnancy involving primarily the femoral head. To our knowledge, only rare cases of femoral meta diaphysis or knee osteonecrosis in pregnancy have been documented in the literature. Read More

Br J Haematol 2022 06 1;197(5):602-608. Epub 2022 Apr 1.

Clinica Pediatrica Università degli Studi di Milano Bicocca, Fondazione MBBM, Monza, Italy.

Osteonecrosis (ON) is a well-known sequela of paediatric acute lymphoblastic leukaemia (ALL) treatment. Incidence differs substantially among studies and the clinical significance of radiological findings is not fully established. We analysed 256 consecutive patients with ALL treated in our Institution between October 2010 and December 2016. Read More

BMJ Case Rep 2022 Mar 29;15(3). Epub 2022 Mar 29.

Orthopedics, PD Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India.

COVID-19 infection affects different organ systems with long-term sequelae, which has been termed as long COVID-19 syndrome. To the best of our knowledge, osteonecrosis of the knee as a part of long COVID-19 syndrome has not been documented. Corticosteroids are being used extensively in moderate and severe cases of COVID-19. Read More

J Orthop Surg Res 2022 Mar 5;17(1):146. Epub 2022 Mar 5.

Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Windmill Road, Headington, Oxford, OX3 7LD, UK.

Background: Isolated lateral compartment knee arthritis is less prevalent than medial. While the reported results of medial unicompartmental knee replacement (UKR) have been good and comparable to total knee replacement, the results of lateral UKR have been mixed. We present the short-term results and survivorship of a fixed-bearing UKR designed specifically for the lateral compartment. Read More

JBJS Case Connect 2022 02 24;12(1). Epub 2022 Feb 24.

Department of Orthopaedics, Dr L H Hiranandani Hospital, Powai, Mumbai, Maharashtra, India.

Case: We report the case of a coronavirus disease 2019 (COVID-19)-recovered, 42-year-old man with osteonecrosis and concomitant acute bacterial osteomyelitis of both hips and his left knee. The patient underwent total hip replacement for both hips and arthroscopic decompression and synovectomy of the knee joint. On follow-up, he has complete and painless range of motion with resolving osteomyelitis and no signs of active infection. Read More

Rev Prat 2021 Oct;71(8):871

Service de rhumatologie, CHU Ibn Rochd, université Hassan II, Casablanca, Maroc.

Stem Cells Dev 2022 Aug 18;31(15-16):488-497. Epub 2022 Feb 18.

OASI Bioresearch Foundation, Gobbi NPO, Milan, Italy.

Bone marrow lesions (BMLs) are typical findings in magnetic resonance imaging present in different pathologies, such as spontaneous insufficiency fractures, osteonecrosis, transient BML syndromes, osteoarthritis, and trauma. The etiology and evolution of BMLs in multiple conditions remain unclear. There is still no gold standard protocol for the treatment of symptomatic BMLs in the knee. Read More

Mod Rheumatol 2022 Jan 4. Epub 2022 Jan 4.

Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.

Osteoporosis is the one of the major adverse outcomes in patients with rheumatoid arthritis (RA). Recently, we and others have been reported many clinical observations related to osteoporosis in Japanese RA patients. In this article, I reviewed these findings. Read More

Biomed Res Int 2021 22;2021:6032559. Epub 2021 Dec 22.

Ankara University, Faculty of Dentistry, Department of Dentomaxillofacial Radiology, Ankara, Turkey.

Aim: Osteonecrosis can affect the mandibular condyle, and bone marrow edema may be a precursor in osteonecrosis development in temporomandibular disorder (TMD) patients. Early detection of bone marrow changes is crucial for occurring osteonecrosis. The purpose of this study was to compare the diagnostic value of fast spin-echo T2 weighted (FSE-T2W), fat-suppressed T2W (FS-T2W), and three-dimensional (3D) fast imaging employing steady-state acquisition (FIESTA-C) MR sequences for early detection of bone marrow changes as well as TMJ soft tissue alterations. Read More