5,971 results match your criteria Osteonecrosis Hip


Effects of Zoledronic Acid and Vitamin E on Surgical- Induced Osteonecrosis of the Femoral Head in Rabbit.

Arch Bone Jt Surg 2018 Nov;6(6):547-553

Research performed at Shaheed Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.

Background: Femoral head osteonecrosis is a progressive disease with disabling outcomes in hip joint if not treated. This study was designed to compare the effects of zoledronic acid plus vitamin E versus zoledronic acid alone in surgical induced femoral head osteonecrosis in rabbits.

Methods: 26 Japanese white adult normal male rabbits at 28-32 weeks old were undertaken surgical femoral dislocation to devastate the femoral neck vessels; the femoral neck vessels were ligated and the hip was relocated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310187PMC
November 2018

Prevalence of CAM-deformity and its influence on therapy success in patients with osteonecrosis of the femoral head.

J Tissue Eng Regen Med 2019 Jan 13. Epub 2019 Jan 13.

Department of Orthopaedics & Traumatology, University of Duisburg-Essen, Essen, Germany.

Osteonecrosis of the femoral head (ONFH) and CAM-type femoroacetabular impingement (FAI) present two different pathologies of the hip joint. The aim of this study is to describe the prevalence of CAM-FAI in a collective of ONFH hips and to evaluate its influence on ONFH therapy outcome. A cohort of 86 ONFH hips with a mean follow-up of 46. Read More

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http://dx.doi.org/10.1002/term.2794DOI Listing
January 2019

Epidemiology of osteonecrosis among older adults in Sweden.

Osteoporos Int 2019 Jan 9. Epub 2019 Jan 9.

Department of Community Medicine and Rehabilitation, Unit of Geriatric Medicine, Umeå University, 90187, Umeå, Sweden.

This study estimated the incidence of osteonecrosis in a Swedish, nationwide cohort of older adults. Osteonecrosis was approximately 10 times more common than in previous studies. The strongest risk factors were dialysis, hip fracture, osteomyelitis, and organ transplantation, but only hip fractures could have contributed substantially to the disease burden. Read More

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http://dx.doi.org/10.1007/s00198-018-04826-2DOI Listing
January 2019

Lateral rim mesh in primary total hip arthroplasty.

Bone Joint J 2019 Jan;101-B(1):96-103

Department of Orthopaedics, Radboud University Medical Center, Nijmegen, The Netherlands.

Aims: The aim of this study was to analyze the effect of a lateral rim mesh on the survival of primary total hip arthroplasty (THA) in young patients, aged 50 years or younger.

Patients And Methods: We compared a study group of 235 patients (257 hips) who received a primary THA with the use of impaction bone grafting (IBG) with an additional lateral rim mesh with a group of 306 patients (343 hips) who received IBG in the absence of a lateral rim mesh during the same period from 1988 to 2015. In the mesh group, there were 74 male and 183 female patients, with a mean age of 35 years (13 to 50). Read More

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http://dx.doi.org/10.1302/0301-620X.101B1.BJJ-2018-0561.R2DOI Listing
January 2019

Rapidly progressive hip disease-A rare entity in Korean population.

Int J Surg Case Rep 2018 24;53:486-489. Epub 2018 Nov 24.

Department of Orthopaedics, Bharati Hospital, Pune, 411043, India. Electronic address:

Introduction: The pathophysiology of rapidly progressive hip disease is still unclear. It is a rare subset of osteoarthritis that mainly affects elderly women and presents with new- onset severe hip pain and dysfunction. It is assumed to be triggered by extremely rapid osteoarthritic changes resulting in impaction of the femoral head into the acetabulum, with successive osteonecrosis and insufficiency of the femoral head. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.11.055DOI Listing
November 2018
1 Read

Clinical characteristics of avascular necrosis in patients with Behçet disease: a case series and literature review.

Rheumatol Int 2019 Jan 17;39(1):153-159. Epub 2018 Dec 17.

Division of Rheumatology, Department of Internal Medicine, Gazi University Faculty of Medicine, 06100, Ankara, Turkey.

Avascular necrosis (AVN), also known as osteonecrosis, is characterized by death of the osteocytes due to inadequate blood supply caused by various mechanisms. The hip is the most common affected joint followed by knee. Incidence of AVN in rheumatic diseases is variable and high corticosteroid (CS) therapy is a known major risk factor for development of AVN. Read More

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http://link.springer.com/10.1007/s00296-018-4224-9
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http://dx.doi.org/10.1007/s00296-018-4224-9DOI Listing
January 2019
2 Reads

Long-term hip survival and factors influencing patient-reported outcomes after transtrochanteric anterior rotational osteotomy for osteonecrosis of the femoral head: A minimum 10-year follow-up case series.

Mod Rheumatol 2018 Dec 17:1-18. Epub 2018 Dec 17.

a Department of Orthopaedic Surgery, Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan.

Objectives: This retrospective study aimed to assess long-term hip survival after transtrochanteric anterior rotational osteotomy (ARO) for osteonecrosis of the femoral head (ONFH) and identify factors influencing patient-reported outcome measures (PROMs) in patients with preserved joints.

Methods: Altogether, 95 consecutive hips in 85 ONFH patients who underwent ARO during 2000-2007 (86.7% follow-up) were studied. Read More

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http://dx.doi.org/10.1080/14397595.2018.1558917DOI Listing
December 2018
1 Read

Transtrochanteric rotational osteotomy for various hip disorders.

J Orthop Sci 2018 Dec 13. Epub 2018 Dec 13.

Department of Orthopaedic Surgery, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Background: Joint-preserving procedures should be considered as much as possible for hip disorders in pediatric and young patients. However, in patients with extensive osteonecrosis (ON) of the femoral head combined with severe collapse and advanced secondary osteoarthritis (OA), the optimal procedure has not been elucidated. This retrospective study aimed to investigate the postoperative outcomes of 11 patients who underwent transtrochanteric rotational osteotomy (TRO) alone or with a combination treatment for various hip disorders in young patients and to evaluate the usefulness of TRO. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09492658183033
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http://dx.doi.org/10.1016/j.jos.2018.10.026DOI Listing
December 2018
3 Reads

Incidence of osteonecrosis and insufficiency fracture of the hip and knee joints based on MRI in 300 renal transplant patients.

Hip Int 2018 Nov 1:1120700018808693. Epub 2018 Nov 1.

1 Department of Orthopaedic Surgery, Tokyo Women's Medical University, Tokyo, Japan.

Introduction:: The purpose of this study was to investigate the incidence of necrosis and insufficiency fracture of the hip and knee using magnetic resonance imaging (MRI) in renal transplant patients.

Methods:: We examined 300 consecutive renal transplant patients using MRI of the hips and knees (T1-weighted coronal MRI) preoperatively and at 3 and 6 months postoperatively. Oblique axial-plane T1-weighted MRI and short-tau inversion-recovery T2-weighted MRI were performed parallel to the femoral neck when distinguishing the osteonecrosis of the femoral head (ONFH) from subchondral insufficiency fracture (SIF) of the femoral head was difficult. Read More

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http://dx.doi.org/10.1177/1120700018808693DOI Listing
November 2018
1 Read

Letter to editor concerning the article "muscle pedicle bone grafting using the anterior one-third of the gluteus medius attached to the greater trochanter for treatment of Association Research Circulation Osseous stage II osteonecrosis of the femoral head" (Cho KJ et al. International Orthopaedics. doi: 10.1007/s00264-018-3839-5).

Authors:
Ali Parsa

Int Orthop 2018 Dec 13. Epub 2018 Dec 13.

Hip Preservation Surgery Division, Department of Orthopedic Surgery, Massachusetts General Hospital at Harvard Medical School, Cambridge street, # 4, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s00264-018-4258-3DOI Listing
December 2018

Immunohistochemical analysis of bone metabolism in osteonecrosis of the femoral head.

Rom J Morphol Embryol 2018 ;59(3):819-824

Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, Romania; Urodiamed Clinic, Craiova, Romania;

Osteonecrosis of the femoral head occurs because of the suppression of blood circulation. At the level of the area affected by the ischemic phenomenon, there are two types of events, in the first stage there is necrosis of the cellular elements, followed by a reparatory phase of the spongy bone tissue. The objective of the study was the histological and immunohistochemical (IHC) analysis of bone metabolism in the repair phase. Read More

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December 2018
1 Read

Mid-term results of short stem total hip arthroplasty in patients with osteonecrosis of the femoral head.

Hip Int 2018 Dec 11:1120700018816011. Epub 2018 Dec 11.

Department of Orthopaedic Surgery, Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima Province, Thailand.

Purpose:: To evaluate the clinical and radiographic mid-term results of short-stem total hip arthroplasty (THA) in patients with osteonecrosis of the femoral head (ONFH).

Methods:: We reviewed 83 cases that underwent Metha stem between November 2010 and November 2012. The appearance of bone trabeculae development and radiolucent line were reviewed and HHS was recorded at 6 months postoperatively then yearly to evaluate the clinical results. Read More

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http://dx.doi.org/10.1177/1120700018816011DOI Listing
December 2018
1 Read

Antiphospholipid score is a novel risk factor for idiopathic osteonecrosis of the femoral head in patients with systemic lupus erythematosus.

Rheumatology (Oxford) 2018 Dec 6. Epub 2018 Dec 6.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Objectives: Idiopathic osteonecrosis of the femoral head (ION) is a common complication of SLE associated with CS therapy. Although the pathogenesis of ION involves local bone ischaemia favoured by thrombophilia, the involvement of aPL in lupus ION remains to be elucidated. We have previously reported the aPL score (aPL-S) as a quantitative marker of aPL and the development of thrombotic events in autoimmune diseases. Read More

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http://dx.doi.org/10.1093/rheumatology/key365DOI Listing
December 2018
1 Read

Impact of acetabular reaming depth on reconstruction of rotation center in primary total hip arthroplasty.

BMC Musculoskelet Disord 2018 Nov 30;19(1):425. Epub 2018 Nov 30.

Department of Orthopedics, China-Japan Union Hospital of Jilin University, 126 xiantai street, Changchun, 130033, People's Republic of China.

Purpose: To study the impact of acetabular reaming depth on reconstruction of rotation center (RC) in unilateral primary total hip arthroplasty (UPTHA) and guide individualized preoperative design.

Methods: 200 postoperative standard bilateral hip anteroposterior radiographs after UPTHA were included, which were collected from January, 2013 to June, 2017 in our hospital. Osteonecrosis of femoral head was the only diagnosis in this cohort. Read More

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http://dx.doi.org/10.1186/s12891-018-2336-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267806PMC
November 2018
2 Reads

Bilateral Developmental Dysplasia of the Hip: Does Closed Reduction Have a Role in Management? Outcome of Closed and Open Reduction in 92 Hips.

J Pediatr Orthop 2018 Nov 20. Epub 2018 Nov 20.

Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK.

Background: Bilateral developmental dysplasia of the hip (DDH) is believed to have a worse outcome than unilateral DDH with the optimal treatment unclear. To define indications for treatment we report a retrospective series of 92 hips (46 patients) who underwent closed reduction (CR) and/or open reduction (OR).

Methods: A total of 58 hips in 29 patients underwent attempted CR using our standardized protocol. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001297DOI Listing
November 2018
8 Reads

Is dynamic locking plate superior than other implants for intracapsular hip fracture: A meta-analysis.

Medicine (Baltimore) 2018 Nov;97(47):e13001

Department of Orthopedics, Puai Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.

Background: We studied the safety and efficacy of dynamic locking plate vs. other implants (cannulated cancellous screws [CCS] or sliding hip screw [SHS]) in patients undergoing intracapsular hip fracture (ICHF).

Methods: We searched Pubmed, Embase, Web of Science, Cochrane library and Google database from inception to March 25, 2018. Read More

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http://dx.doi.org/10.1097/MD.0000000000013001DOI Listing
November 2018
3 Reads

T ρ and T mapping for the determination of articular cartilage denaturalization with osteonecrosis of the femoral head: A prospective controlled trial.

J Magn Reson Imaging 2018 Nov 21. Epub 2018 Nov 21.

Orthopedic Department, First Affiliated Hospital of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou, P.R. China.

Background: In the future, biochemical MRI might provide a valuable noninvasive quantitative analysis of the biochemical composition of cartilage in osteonecrosis of the femoral head (ONFH).

Purpose: To investigate the diagnostic performance of T ρ and T mapping in cartilage denaturalization with ONFH and to determine the correlation between T ρ and T mapping and the Association Research Circulation Osseous (ARCO) stage.

Study Type: Prospective. Read More

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http://dx.doi.org/10.1002/jmri.26267DOI Listing
November 2018
7 Reads

Traumatic Pubic-type Anterior Dislocation of the Hip with an Ipsilateral Greater Trochanter Fracture: Case Report and Review of Literature.

Cureus 2018 Sep 11;10(9):e3287. Epub 2018 Sep 11.

Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, IND.

Due to the inherent stability of the hip joint, hip dislocations constitute a relatively small proportion of all the traumatic dislocations encountered in the emergency department. Among them, the anterior type of hip dislocation is less common than the posterior type of dislocation. Anterior dislocations are usually associated with an injury to other, nearby structures like the acetabulum and femoral head. Read More

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https://www.cureus.com/articles/14606-traumatic-pubic-type-a
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http://dx.doi.org/10.7759/cureus.3287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235655PMC
September 2018
6 Reads

Orthopaedic challenges for mucopolysaccharidoses.

Ital J Pediatr 2018 Nov 16;44(Suppl 2):123. Epub 2018 Nov 16.

Institute for Maternal and Child Health IRCCS Burlo Garofolo, Via dell'Istria, 65, 34137, Trieste, Italy.

Mucopolysaccharidoses (MPS) are a group of diseases characterized by abnormal accumulation of glycosaminoglycans (GAGs). Although there are differences among the various disease types, the osteoarticular system is always involved. The aim of the present study was to establish a framework for MPS-related orthopaedic manifestations and for their treatment. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0557-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238259PMC
November 2018
4 Reads

The mean ten-year results of metal-on-metal hybrid hip resurfacing arthroplasty.

Bone Joint J 2018 Nov;100-B(11):1424-1433

Joint Replacement Institute at St Vincent Medical Center, Los Angeles, California, USA.

Aims: This study presents the long-term survivorship, risk factors for prosthesis survival, and an assessment of the long-term effects of changes in surgical technique in a large series of patients treated by metal-on-metal (MoM) hip resurfacing arthroplasty (HRA).

Patients And Methods: Between November 1996 and January 2012, 1074 patients (1321 hips) underwent HRA using the Conserve Plus Hip Resurfacing System. There were 787 men (73%) and 287 women (27%) with a mean age of 51 years (14 to 83). Read More

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https://online.boneandjoint.org.uk/doi/10.1302/0301-620X.100
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http://dx.doi.org/10.1302/0301-620X.100B11.BJJ-2017-1459.R2DOI Listing
November 2018
6 Reads

A special superior cortex compressive fracture of femoral neck: Two case reports.

Medicine (Baltimore) 2018 Oct;97(43):e12876

Orthopaedic Center of People's Liberation Army, the Affiliated Southeast Hospital of Xiamen University, Zhangzhou.

Rationale: Garden type I femoral neck fractures are incomplete stable fractures with impaction in valgus fractures that the question of whether there exists Garden type I femoral neck fracture is currently uncertain. There is still disagreement on the existence of the Garden type I fractures.

Patient Concerns: Herein we report 2 cases with the Garden type I femoral neck fractures. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810260-0002
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http://dx.doi.org/10.1097/MD.0000000000012876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221757PMC
October 2018
6 Reads

Autologous bone marrow-derived CD133 cells with core decompression as a novel treatment method for femoral head osteonecrosis: a pilot study.

Cytotherapy 2019 Jan 5;21(1):107-112. Epub 2018 Nov 5.

Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research, Tehran, Iran. Electronic address:

Background: Avascular necrosis (AVN) of femoral head is a progressive bone disease due to ischemia of femoral head; patients experience pain and they can not do normal activity. There is not an effective way to treat the cause of this disease. In recent studies, treatment of this disease using pluripotent stem cell-derived mesenchyme is safe and effective, but this method needs more investigation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14653249183064
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http://dx.doi.org/10.1016/j.jcyt.2018.10.005DOI Listing
January 2019
3 Reads

IL6 receptor blockade preserves articular cartilage and increases bone volume following ischemic osteonecrosis in immature mice.

Osteoarthritis Cartilage 2018 Nov 4. Epub 2018 Nov 4.

Center for Excellence in Hip Disorders, Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA; Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390-8883, USA. Electronic address:

Objective: Juvenile ischemic osteonecrosis (JIO) of the femoral head is one of the most serious hip disorders causing a permanent deformity of the femoral head in childhood. We recently reported that interleukin 6 (IL6) is predominantly increased in the hip synovial fluid of patients with JIO and that articular chondrocytes are primary source of IL6. This study investigated whether an inhibition of IL6 receptor improves cartilage preservation and bone healing in JIO. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584183151
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http://dx.doi.org/10.1016/j.joca.2018.10.010DOI Listing
November 2018
12 Reads

Analysis of the long-term efficacy of core decompression with synthetic calcium-sulfate bone grafting on non-traumatic osteonecrosis of the femoral head.

Med Sci (Paris) 2018 Oct 7;34 Focus issue F1:43-46. Epub 2018 Nov 7.

Department of general surgery, 6th affiliated hospital of Wenzhou medical university (Lishui People's Hospital), Lishui Zhejiang province, No.15 Dazhong Road, Liandu district, Lishui 323000 PR China.

Objective: to investigate the safety and long-term efficacy of core decompression with synthetic calcium-sulfate bone grafting on non-traumatic osteonecrosis of the femoral head.

Method: a total of 76 patients with non-traumatic osteonecrosis of the femoral head were admitted to our hospital from February 2012 to November 2014 and included in the study. All the patients were treated by core decompression with synthetic calcium-sulfate bone grafting. Read More

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http://dx.doi.org/10.1051/medsci/201834f108DOI Listing
October 2018
1 Read

Early results of surgery for femoroacetabular impingement in patients with osteonecrosis of femoral head.

Authors:
Tarun Goyal

SICOT J 2018 6;4:47. Epub 2018 Nov 6.

Department of Orthopaedics, All India Institute of Medical Sciences - Rishikesh, Virbhadra Marg, Rishikesh 209201, India.

Purpose: Femoroacetabular impingement and its surgical treatment have not been described before in osteonecrosis of femoral head. We present here outcomes of 15 patients with femoroacetabular impingement secondary to osteonecrosis of femoral head. This results from partial collapse of femoral head, particularly in the anterosuperior region, secondary to osteonecrosis. Read More

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https://www.sicot-j.org/10.1051/sicotj/2018038
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http://dx.doi.org/10.1051/sicotj/2018038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219822PMC
November 2018
8 Reads

Unexpected dislocation following accurate total hip arthroplasty caused by excessive hip joint laxity during myasthenic crisis: a case report.

J Med Case Rep 2018 Nov 6;12(1):331. Epub 2018 Nov 6.

Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Kawahara-cho 54, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: Dislocation following total hip arthroplasty is mainly caused by malposition. However, the coexistence of neuromuscular disorders is also considered a risk for dislocation due to excessive hip joint laxity. To minimize risk of dislocation, preoperative planning using combined anteversion has been widely used. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1886-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219087PMC
November 2018
8 Reads

Unusual indication of Cell therapy for hip osteonecrosis after pregnancy.

SICOT J 2018 5;4:46. Epub 2018 Nov 5.

Hôpital Henri Mondor, 51 avenue du Maréchal de Tassigny, 94000 Creteil, France.

Purpose: Osteonecrosis is a rare event during or after pregnancy. Due to the low number of cases, there is no report of long-term results after conservative surgery in this population.

Method: From 1992 to 2010, 145 consecutive female patients with unilateral symptomatic (94 stage I and 51 stage II) left hip osteonecrosis (ON) related to pregnancy were treated between 4 and 16 months after delivery with percutaneous mesenchymal stem cell (MSC) injection obtained from bone marrow concentration. Read More

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http://dx.doi.org/10.1051/sicotj/2018044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216759PMC
November 2018
1 Read

The role of cell therapies and hip arthroscopy in the management of osteonecrosis: an update.

J Hip Preserv Surg 2018 Aug 14;5(3):202-208. Epub 2018 Jun 14.

Orthopaedic Department, St George, Chania General Hospital, Chania, Greece.

The exact pathophysiology of osteonecrosis of the femoral head (ONFH) is still unknown. There is evidence to suggest that in ON there is decreased population and altered function of the mesenchymal stem cells (MSCs) of the femoral head. This could influence both the actual occurrence of ON itself and the repair process that follows. Read More

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https://academic.oup.com/jhps/article/5/3/202/5038313
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http://dx.doi.org/10.1093/jhps/hny021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206693PMC
August 2018
6 Reads

[Effect of robot navigation assisted core decompression combined with bone graft treatment of early stage osteonecrosis of the femoral head].

Zhonghua Wai Ke Za Zhi 2018 Nov;56(11):849-853

Department of Osteoarthropathy, Yantaishan Hospital, Yantai 264001, China.

To evaluate the effects of orthopedic robot navigation system used in core decompression combined with bone graft surgery for osteonecrosis of the femoral head (ONFH). A retrospective analysis was performed on 9 patients (16 hips) underwent core decompression surgery combined with bone graft treatment for early ONFH in ARCO Ⅱat Department of Osteoarthropathy, Yantaishan Hospital from June 2016 to February 2018.There were 7 males and 2 females, aged 44. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2018.11.011DOI Listing
November 2018
6 Reads

Multifocal avascular osteonecrosis despite appropriate anticoagulation therapy in a patient with systemic lupus erythematosus and antiphospholipid syndrome.

BMJ Case Rep 2018 Nov 1;2018. Epub 2018 Nov 1.

Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d'Aosta Network for Rare Diseases, University of Turin and S. Giovanni Bosco Hospital, Turin, Italy.

Multifocal avascular osteonecrosis (AON) is a serious manifestation of systemic lupus erythematosus (SLE). Prothrombotic factors, especially antiphospholipid antibodies (aPL), have been associated with the development of AON; therefore, attenuating the procoagulant state while balancing the haemorrhagic risks might have a rationale when managing this condition. We report a case of a 37-year-old patient with SLE, treated with low doses of corticosteroids and immunosuppressive therapy, who was started on vitamin K antagonist following an episode of deep vein thrombosis while having persistent positivity for aPL. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22553
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http://dx.doi.org/10.1136/bcr-2018-225532DOI Listing
November 2018
7 Reads

New and emerging concepts in the use of denosumab for the treatment of osteoporosis.

Ther Adv Musculoskelet Dis 2018 Nov 22;10(11):209-223. Epub 2018 Oct 22.

New Mexico Clinical Research & Osteoporosis Center, 300 Oak St NE, Albuquerque, NM 87106, USA.

Denosumab is a fully human monoclonal antibody to receptor activator of nuclear factor kappa-B ligand (RANKL), a cytokine expressed by cells of the osteoblast lineage that is a key regulator of osteoclastic bone resorption. By binding and neutralizing RANKL, denosumab inhibits osteoclast differentiation, activity, and survival. Clinical trials in postmenopausal women with osteoporosis have shown that it reduces the risk of vertebral fractures, nonvertebral fractures, and hip fractures, with a generally favorable safety profile. Read More

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http://dx.doi.org/10.1177/1759720X18805759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204627PMC
November 2018
10 Reads

Relationship of common variants in VEGFA gene with osteonecrosis of the femoral head: A Han Chinese population based association study.

Sci Rep 2018 Nov 1;8(1):16221. Epub 2018 Nov 1.

Department of Trauma, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.

The pathology of non-traumatic osteonecrosis of the femoral head (ONFH) is complex. Several studies have linked some polymorphisms of vascular endothelial growth factors A (VEGFA) with ONFH, but the results are not consistent and are even conflicting. In the study, 22 single nucleotide polymorphisms (SNPs) in VEGFA were genotyped in 1,762 subjects (489 cases and 1,273 controls). Read More

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http://www.nature.com/articles/s41598-018-34352-4
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http://dx.doi.org/10.1038/s41598-018-34352-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212426PMC
November 2018
2 Reads

Pericollapse Stage of Osteonecrosis of the Femoral Head: A Last Chance for Joint Preservation.

Chin Med J (Engl) 2018 Nov;131(21):2589-2598

Department of Orthopaedic, Graduate School of Peking Union Medical College, China-Japan Friendship Hospital Institute of Clinical Medicine, Beijing 100029, China.

Objective: To propose a new definition of the pericollapse stage of osteonecrosis of the femoral head (ONFH) and review its significance in disease diagnosis and treatment selection.

Data Sources: A search for eligible studies was conducted in three electronic databases including PubMed, Cochrane Library, and Embase up to August 10, 2018, using the following keywords: "osteonecrosis", "prognosis", and "treatment".

Study Selection: Investigations appraising the clinical signs, symptoms, and imaging manifestations in different stages of ONFH were included. Read More

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http://dx.doi.org/10.4103/0366-6999.244111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213842PMC
November 2018
1 Read

Effect of surgical treatment on the quality of life in patients with non-traumatic avascular necrosis of the femoral head.

Rev Bras Ortop 2018 Nov-Dec;53(6):773-777. Epub 2018 Feb 3.

Medical School, Kermanshah University of Medical Science, Kermanshah, Iran.

Objective: Avascular necrosis of the hip is a common debilitating disease during the fourth and fifth decades of life. This study attempted to evaluate quality of life in patients with avascular necrosis of the hip joint before and after surgery.

Methods: In this study, 40 patients with avascular necrosis of the hip who underwent total hip arthroplasty, bipolar surgery, or cord compression were examined during 2006-2013. Read More

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http://dx.doi.org/10.1016/j.rboe.2017.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205024PMC
February 2018
2 Reads

Outcomes for core decompression with multiple drilling of the osteonecrosis of the femoral head in patients with solid organ transplantation.

Eklem Hastalik Cerrahisi 2018 Dec;29(3):159-64

Department of Orthopedics and Traumatology, Başkent University, Faculty of Medicine, 06490, Bahçelievler, Ankara, Turkey.

Objectives: This study aims to investigate the clinical and radiological outcomes of core decompression surgery performed with multiple drilling in solid organ transplantation patients with osteonecrosis of femoral head (ONFH) and evaluate the effectiveness of this procedure in regard to duration of corticosteroid use and stage of osteonecrosis.

Patients And Methods: A total of 22 solid organ transplantation (kidney, liver or heart) patients (14 males, 8 females; mean age 43.3 years; range, 23 to 67 years) who were scheduled to undergo core decompression surgery with multiple drilling for ONFH were evaluated. Read More

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http://dx.doi.org/10.5606/ehc.2018.61348DOI Listing
December 2018
2 Reads

Mid- to long-term results of resurfacing hip arthroplasty in Japanese patients: a comparison of osteoarthritic vs non-osteoarthritic patients.

J Artif Organs 2018 Oct 28. Epub 2018 Oct 28.

Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8641, Japan.

Past reports showed good mid-term results of RHA for Japanese patients. However, few reports have compared the mid- to long-term results for RHA in Japanese patients with and without osteoarthritis. Therefore, this study investigated the mid- to long-term results of RHA in Japanese patients with osteoarthritis compared to those without. Read More

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http://link.springer.com/10.1007/s10047-018-1077-7
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http://dx.doi.org/10.1007/s10047-018-1077-7DOI Listing
October 2018
4 Reads

Femur neck fracture in young adults, is it really an urgent surgery indication: retrospective clinical study.

Pan Afr Med J 2018 12;30:112. Epub 2018 Jun 12.

Dr Lutfi Kirdar Kartal Training and Research Hospital, Department of Orthopaedics and Traumatology, Istanbul, Turkey.

Introduction: Femur neck fracture comprises a significant part of intracapsular femur fracture in the intracapsular area of proximal femur and it is mostly seen in elder people. However, these kinds of fractures may be seen in young adults. The present study aims to search factors that affect femoral neck fractures in young adults after surgery carried out by internal determination method. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.112.13643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195237PMC
November 2018
1 Read

New advances in stem cell therapy for osteonecrosis of the femoral head.

Curr Stem Cell Res Ther 2018 Oct 25. Epub 2018 Oct 25.

Institute of Orthopaedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an. China.

Osteonecrosis of the femoral head (ONFH) is a common refractory orthopedic disease with multiple etiologies that more frequently occurs in middle-aged and young people. ONFH is the main cause of hip replacement in young patients. Since Professor Hernigou first reported the use of stem cells in the treatment of early stage ONFH, a large number of studies have demonstrated the potential of stem cells in the treatment of adult patients with ONFH. Read More

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http://dx.doi.org/10.2174/1574888X13666181025120252DOI Listing
October 2018
12 Reads

Clinical efficiency of bone marrow mesenchymal stem cell implantation for osteonecrosis of the femoral head: a matched pair control study with simple core decompression.

Stem Cell Res Ther 2018 Oct 25;9(1):274. Epub 2018 Oct 25.

Department of Orthopedic Surgery, College of Medicine, Inha University Hospital, 7-206, 3rd Street Sinheung-Dong, Jung-Gu, Incheon, 400-103, South Korea.

Background: To date, several trials have reported the use of mesenchymal stem cell (MSC) implantation for osteonecrosis of the femoral head (ONFH). However, the clinical outcomes have not been conclusive. This study compared the clinical and radiological results of bone marrow mesenchymal stem cell (BMMSC) implantation with traditional simple core decompression (CD) using a matched pair case-control design. Read More

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http://dx.doi.org/10.1186/s13287-018-1030-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202854PMC
October 2018
6 Reads

Stem cell therapy for treating osteonecrosis of the femoral head: From clinical applications to related basic research.

Stem Cell Res Ther 2018 Oct 25;9(1):291. Epub 2018 Oct 25.

Institute of Orthopedics, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, Chinese PLA General Hospital, Beijing, 100853, China.

Osteonecrosis of the femoral head (ONFH) is a refractory disease that is associated with collapse of the femoral head, with a risk of hip arthroplasty in younger populations. Thus, there has been an increased focus on early interventions for ONFH that aim to preserve the native articulation. Stem cell therapy is a promising treatment, and an increasing number of recent studies have focused on this topic. Read More

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http://dx.doi.org/10.1186/s13287-018-1018-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202807PMC
October 2018
7 Reads

Etiologic Classification Criteria of ARCO on Femoral Head Osteonecrosis Part 2: Alcohol-Associated Osteonecrosis.

J Arthroplasty 2019 Jan 22;34(1):169-174.e1. Epub 2018 Sep 22.

Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.

Background: Although alcohol is a leading risk factor for osteonecrosis of the femoral head (ONFH) and its prevalence reportedly ranges from 20% to 45%, there are no unified classification criteria for this subpopulation. In 2015, Association Research Circulation Osseous decided to develop classification criteria for alcohol-associated ONFH.

Methods: In June of 2017, Association Research Circulation Osseous formed a task force to conduct a Delphi survey. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08835403183078
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http://dx.doi.org/10.1016/j.arth.2018.09.006DOI Listing
January 2019
8 Reads

Diagnostic accuracy of digital radiography for the diagnosis of osteonecrosis of the femoral head, revisited.

Acta Radiol 2018 Oct 16:284185118808083. Epub 2018 Oct 16.

1 Department of Radiology, Seoul National University Bundang Hospital, Seoul, Republic of Korea.

Background The radiographic diagnosis of osteonecrosis of the femoral head (ONFH) is challenging for radiologists. Purpose To measure the sensitivity and specificity of digital radiography for diagnosing ONFH and to evaluate the diagnostic value of the frog-leg view. Material and Methods Patients diagnosed with ONFH by magnetic resonance imaging (MRI) (n = 132) and normal controls (n = 69) were included. Read More

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http://journals.sagepub.com/doi/10.1177/0284185118808083
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http://dx.doi.org/10.1177/0284185118808083DOI Listing
October 2018
2 Reads

Outcomes of Conversion Total Hip Arthroplasty From Free Vascularized Fibular Grafting.

J Arthroplasty 2019 Jan 21;34(1):88-92. Epub 2018 Sep 21.

Duke University Hospital, NC.

Background: Conversion total hip arthroplasties (THAs) from prior free vascularized fibular grafting (FVFG) are infrequently reported in the literature. We characterized the perioperative outcomes of patients undergoing conversion THA and compared them with those of a matched cohort of patients undergoing primary THA for osteonecrosis of the femoral head and neck (ONFHN).

Methods: The institutional database was queried for patients with FVFG requiring conversion to THA. Read More

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http://dx.doi.org/10.1016/j.arth.2018.09.041DOI Listing
January 2019
1 Read

Core decompression, lesion clearance and bone graft in combination with Tongluo Shenggu decoction for the treatment of osteonecrosis of the femoral head: A retrospective cohort study.

Medicine (Baltimore) 2018 Oct;97(41):e12674

Department of Orthopedics, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shanxi Province, P.R. China.

The aim of this study was to evaluate the clinical effect of core decompression (CD), lesion clearance, and bone graft in combination with Tongluo Shenggu decoction for the treatment of osteonecrosis of the femoral head (ONFH).A total of 75 patients (92 hips), with ONFH at Association Research Circulation Osseous (ARCO) stages II to IIIA, were studied and divided into treatment group and control group. In control group, patients were treated with the CD in combination with autologous or artificial ceramic bone graft. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810120-0004
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http://dx.doi.org/10.1097/MD.0000000000012674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203527PMC
October 2018
16 Reads

Competitive Running After Total Hip Arthroplasty: The World's Fastest Total Hip: A Case Report.

JBJS Case Connect 2018 Oct-Dec;8(4):e81

Orthopaedic Surgery and Rehabilitation Department, University of Vermont, Burlington, Vermont.

Case: We report the case of a young man who underwent total hip arthroplasty (THA) for osteonecrosis at the age of 20 years, and subsequently competed in collegiate long-distance running. The pinnacle of his career was setting the school record time of 3:47.64 (min:sec) in the 1,500-m "metric mile" run (equivalent to 4:05. Read More

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http://dx.doi.org/10.2106/JBJS.CC.18.00030DOI Listing
October 2018
2 Reads

Total hip arthroplasty after failed transtrochanteric rotational osteotomy for osteonecrosis of the femoral head: A systematic review and meta-analysis.

Orthop Traumatol Surg Res 2018 Dec 4;104(8):1163-1170. Epub 2018 Oct 4.

Department of Orthopaedic Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesak, Ichiharai, Chiba 299-0111, Japan.

Background: Several studies have reported regarding total hip arthroplasty (THA) for osteonecrosis of the femoral head after failed transtrochanteric rotational osteotomy (TRO). However, to our knowledge, no formal systematic review and meta-analysis have been published yet summarizing the clinical results of a THA after failed TRO. Therefore, we conducted a systematic review and meta-analysis of the THA outcomes after failed TRO. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18770568183027
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http://dx.doi.org/10.1016/j.otsr.2018.06.019DOI Listing
December 2018
11 Reads

The Glycosaminoglycan Content of Hip Cartilage in Osteonecrosis of Femoral Head: Evaluation with Delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage.

Cartilage 2018 Oct 3:1947603518803732. Epub 2018 Oct 3.

1 Department of Orthopaedic Surgery, Beijing Key Lab Immune-Mediated Inflammatory Diseases, China-Japan Friendship Hospital, Beijing, China.

Objective Hip cartilage quality is essential for the success of joint-preserving surgery for osteonecrosis. This study aimed to characterize cartilage changes in osteonecrosis of femoral head (ONFH) using delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC). Design Fifteen asymptomatic (control) and 60 ONFH subjects were included in this study. Read More

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http://journals.sagepub.com/doi/10.1177/1947603518803732
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http://dx.doi.org/10.1177/1947603518803732DOI Listing
October 2018
2 Reads

What is the role of core decompression in the early stages of osteonecrosis of the femoral head? Evaluation of the surgical result by functional score and radiological follow-up.

Rev Bras Ortop 2018 Sep-Oct;53(5):537-542. Epub 2018 Aug 2.

Instituto de Ortopedia e Traumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Objectives: This study is aimed at evaluating whether core decompression of the femoral head in the early stages of femoral head osteonecrosis improves patients' subjective perception of pain and avoids the progression of the disease to a femoral head collapse and a final indication of total hip arthroplasty.

Methods: Eighteen patients (30 hips) in the early stages of the disease (Ficat and Arlet 1 and 2A) were evaluated through clinical, radiological, risk factor maintenance, and by the functional Merle D'Aubigné, and Postel score before and after core decompression of the femoral head.

Results: There was an improvement of symptoms up to the sixth month in 83. Read More

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http://dx.doi.org/10.1016/j.rboe.2018.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147800PMC
August 2018
2 Reads

Tracking Cell Transplants in Femoral Osteonecrosis with Magnetic Resonance Imaging: A Proof-of-Concept Study in Patients.

Clin Cancer Res 2018 Dec 17;24(24):6223-6229. Epub 2018 Sep 17.

Department of Radiology, Pediatric Radiology, Lucile Packard Children's Hospital, Stanford University, Stanford, California.

Purpose: Osteonecrosis is a devastating complication of high-dose corticosteroid therapy in patients with cancer. Core decompression for prevention of bone collapse has been recently combined with the delivery of autologous concentrated bone marrow aspirates. The purpose of our study was to develop an imaging test for the detection of transplanted bone marrow cells in osteonecrosis lesions. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-18-1687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295241PMC
December 2018
6 Reads