6,315 results match your criteria Osteomyelitis Chronic


Spondylodiscitis in end-stage renal disease: a systematic review.

J Neurosurg Spine 2019 Feb 15:1-9. Epub 2019 Feb 15.

1Department of Neurological Surgery, University of Miami, Miami, Florida; and.

OBJECTIVEDiscitis and osteomyelitis are seen in end-stage renal disease (ESRD) patients due to repeated vascular access for hemodialysis and urinary tract infections leading to recurrent bacteremia. Discitis and osteomyelitis are underdiagnosed due to the nonspecific initial presentation of back pain. In this article, we review the literature for better understanding of the problem and the importance of early diagnosis by primary care physicians and nephrologists. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18824DOI Listing
February 2019

An in vitro biofilm model of Staphylococcus aureus infection of bone.

Lett Appl Microbiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Applied Sciences, University of the West of England, Bristol, Frenchay Campus, Coldharbour Lane, Bristol, BS16 1QY.

Chronic osteomyelitis is difficult to treat, with biofilm growth and the diffusion barrier to antibiotics presented by bone contributory factors. The aim of this study was to develop and evaluate an in vitro model of osteomyelitis. A bioluminescent strain of Staphylococcus aureus was grown in bone blocks made from bovine femur. Read More

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http://dx.doi.org/10.1111/lam.13131DOI Listing
February 2019

L-shaped corticotomy with bone flap sliding in the management of chronic tibial osteomyelitis: surgical technique and clinical results.

J Orthop Surg Res 2019 Feb 12;14(1):47. Epub 2019 Feb 12.

Orthopaedic Department, Minhang Branch, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.

Background: We described the use of the technique of L-shaped corticotomy with bone flap sliding to treat chronic osteomyelitis of the tibia in eight patients and presented the preliminary results.

Methods: L-shaped corticotomy with bone flap sliding was performed in eight patients between 2007 and 2014. All patients had chronic tibial osteomyelitis involving the anterior tibial cortex with intact and healthy posterior cortex. Read More

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http://dx.doi.org/10.1186/s13018-019-1086-0DOI Listing
February 2019

Clinical and Microbiologic Variables Predictive of Orthopedic Complications Following S. aureus Acute Hematogenous Osteoarticular Infections in Children.

Clin Infect Dis 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX.

Background: Staphylococcus aureus is the most common cause of acute hematogenous osteoarticular infections (AHOAIs) in children. The risk factors for the development of orthopedic complications (OC) after AHOAI are poorly understood. We sought to describe clinical and microbiologic variables present on the index admission which may predict OC in S. Read More

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http://dx.doi.org/10.1093/cid/ciz109DOI Listing
February 2019
1 Read

Chronic Candida osteomyelitis of hard palate and nose: A diagnostic quandary.

Med Mycol Case Rep 2019 Jun 14;24:1-4. Epub 2019 Jan 14.

Department of Microbiology, All India Institute of Medical Sciences, Jodhpur 2, Basni, Jodhpur 342005, India.

induced osteomyelitis is infrequent. There is scarcity of literature on this entity in maxillofacial region and thus there is possibility to mismanage such cases. We are presenting a case of chronic maxillofacial osteomyelitis causing palatal and septal perforation with saddle nose deformity in a young lady with commencement and progression of disease process over two pregnancies. Read More

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http://dx.doi.org/10.1016/j.mmcr.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357845PMC
June 2019
1 Read

Endodontic Infection-induced Inflammation Resembling Osteomyelitis of the Jaws in Toll-like Receptor 2/Interleukin 10 Double-knockout Mice.

J Endod 2019 Feb;45(2):181-188

Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts; Department of Endodontics, Boston University Goldman School of Dental Medicine, Boston, Massachusetts.

Introduction: In general, mice develop chronic and nonhealing periapical lesions after endodontic infection. Surprisingly, we recently found that toll-like receptor 2 (TLR2)/interleukin 10 (IL-10) double-knockout (dKO) mice exhibited acute but resolving osteomyelitislike inflammation. In this study, we examined the kinetics of endodontic infection-induced inflammation in TLR2/IL-10 dKO mice and explored a potential mechanism of periapical wound healing mediated by the hypoxia-inducible factor 1 alpha (HIF-1α) subunit and arginase 1. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364571PMC
February 2019
1 Read

Osteomyelitis of the Calcaneus With Pathologic Fracture.

J Foot Ankle Surg 2019 Jan 23. Epub 2019 Jan 23.

Attending Physician, Geisinger Health System, Danville, PA.

Pathologic fractures of the calcaneus secondary to osteomyelitis (OM) have rarely been reported in the literature. This case series describes 5 patients who were treated in our institution for chronic OM of the calcaneus and subsequently suffered a fracture of the involved calcaneus in the absence of trauma. All 5 patients had a history of insulin-dependent diabetes mellitus and were treated with a range of surgical treatments including open reduction and internal fixation, external fixation, and excision of the fracture fragment. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.09.016DOI Listing
January 2019
2 Reads

Two cases of Osteoarticular Mucor menace: A diagnostic and management conundrum.

Drug Discov Ther 2018 ;12(6):374-378

Department of Medicine, All India Institute of Medical Sciences.

Mucormycosis is an uncommon aggressive fungal infection usually seen in immunocompromised hosts or patients with burns and trauma. The common presentations include rhino-orbital-cerebral and pulmonary involvement. Osteoarticular involvement is a rare presentation of this disease. Read More

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http://dx.doi.org/10.5582/ddt.2018.01064DOI Listing
January 2018

Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections.

Int J Nanomedicine 2019 11;14:469-481. Epub 2019 Jan 11.

Department of Nursing, Chang Gung University of Science and Technology, Puzi City, Chiayi County 61363, Taiwan,

Background: Periprosthetic joint infections (PJIs) have a high incidence of recurrence after total joint replacement and are difficult to treat by debridement or antibiotic treatment. Curcumin is a natural product with anti-inflammatory and anti-bacterial properties. The low bioactivity of curcumin in water restricts its clinical application. Read More

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https://www.dovepress.com/curcumin-nanoparticles-are-a-promi
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http://dx.doi.org/10.2147/IJN.S191504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333393PMC
January 2019
5 Reads

Antibiotic-loaded Porous Alumina Ceramic for One-stage Surgery for Chronic Osteomyelitis.

J Am Acad Orthop Surg Glob Res Rev 2018 Nov 2;2(11):e079. Epub 2018 Nov 2.

Orthopedic Department (Dr. Fiorenza), Limoges teaching Hospital; the Reference Center for Complex Bone and Joint Infections (Dr. Fiorenza, Dr. Durox, and Dr. Denes); the Infectious Diseases Department (Dr. Durox), Limoges teaching Hospital; the Pharmacology Laboratory (Dr. El Balkhi), Limoges teaching Hospital; the R&D Department (Dr. Denes), I.Ceram; and the Infectious Diseases Department (Dr. Denes), Clinique Chénieux, Limoges, France.

The classic treatment of chronic osteomyelitis is usually a two-stage surgery combined with systemic antibiotic therapy for several months. We report the case of a patient presenting a chronic osteomyelitis caused by methicillin-resistant who was treated with a one-stage surgery using an antibiotic-loaded ceramic. We used a porous alumina ceramic loaded with gentamicin to reconstruct the bone removed during débridement and to avoid its colonization. Read More

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http://dx.doi.org/10.5435/JAAOSGlobal-D-18-00079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324901PMC
November 2018

Combination of Girdlestone Pseudoarthroplasty and Negative Pressure Wound Therapy with Instillation and Dwell in the Treatment of Invasive Osteomyelitis of the Proximal Femur.

Cureus 2018 Nov 6;10(11):e3552. Epub 2018 Nov 6.

Surgery, Washington University, Barnes-Jewish Hospital, St. Louis, USA.

Osteomyelitis is a progressively destructive invasive infection of the bone that can result in both localized and systemic illness. This includes an acute suppurative infection, generalized weakness, a failure to thrive, a pathological fracture, and non-healing ulcers. When chronic osteomyelitis develops, therapeutic options are limited, as antimicrobial agents cannot penetrate the necrotic bone, and repeated surgical debridement may be needed. Read More

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http://dx.doi.org/10.7759/cureus.3552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324859PMC
November 2018
10 Reads

Antiseptic negative pressure instillation therapy for the treatment of septic wound healing deficits in oral and maxillofacial surgery.

J Craniomaxillofac Surg 2018 Dec 19. Epub 2018 Dec 19.

Department of Oral and Maxillofacial Surgery (Head of the institution: Prof. Dr. med. Dr. med. Dent. Marco Rainer Kesting), University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glückstraße 11, 91054, Erlangen, Germany; Section of Oral and Maxillofacial Surgery, Department of Otorhinolaryngology, Klinikum Augsburg Süd, 86156, Augsburg, Germany.

Introduction: Impaired wound healing, chronic wounds and extended soft tissue defects present a crucial problem in reconstructive surgery of the head and neck region, even more after radiation therapy. In such cases the standard is a prolonged open wound treatment. The negative pressure instillation therapy might present an alternative therapy option. Read More

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http://dx.doi.org/10.1016/j.jcms.2018.12.006DOI Listing
December 2018

Eosinophilic Granuloma of Mandible: A Diagnostic Challenge.

Kathmandu Univ Med J (KUMJ) 2018 Apr-Jun;16(62):201-203

Department of Oral Surgery, Peoples Dental College, Shorakhutte, Kathmandu, Nepal.

Eosinophilic Granuloma is the mildest and localized form of Langerhans Cell Histiocytosis and is characterized by clonal proliferation of Langerhans cells. It is a rare disease, accounting for less than 1% of all the osseous neoplasms. It has predilection for the axial skeleton and incidence in jaws is just 7. Read More

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January 2019
1 Read

Anemia in Patients with Diabetic Foot Ulcer: Effects on Diabetic Microvascular Complications and Related Conditions.

Endocr Metab Immune Disord Drug Targets 2019 01 11. Epub 2019 Jan 11.

Cukurova University Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology, Adana. Turkey.

Objective: We aimed to investigate the etiology and prevalence of anemia in patients with diabetic foot ulcers and the relationship between both microvascular complications and related conditions and anemia.

Method: We retrospectively collected and evaluated the data of 225 patients with diabetic foot ulcer followed at our clinic. The demographic characteristics of the patients were analyzed. Read More

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http://www.eurekaselect.com/168896/article
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http://dx.doi.org/10.2174/1871530319666190111121913DOI Listing
January 2019
6 Reads

Oral manifestations of sickle cell disease.

Br Dent J 2019 Jan;226(1):27-31

Henri Mondor Hospital, Dental Department, Paris-Descartes University, Ile-de France, France.

Sickle cell disease is one of the most common autosomal recessive genetic diseases. It gives rise to abnormally shaped red blood cells with altered function, the primary clinical features being haemolytic anaemia and vascular occlusion. Acute complications are frequent and variable and include chest syndrome, stroke, infection mainly due to asplenia, bone pain and priapism. Read More

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http://www.nature.com/doifinder/10.1038/sj.bdj.2019.4
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http://dx.doi.org/10.1038/sj.bdj.2019.4DOI Listing
January 2019
11 Reads

Research on the clinical efficacy of the combination of Chinese traditional medicine and western medicine on the chronic traumatic tibial osteomyelitis.

Pak J Pharm Sci 2018 Nov;31(6(Special)):2841-2845

Department of Orthopedic, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54, Mail Circuit, Shangcheng District, Hangzhou, Zhejiang, China.

The research investigation is carried to observe the clinical efficacy of the combination of Chinese traditional medicine (TCM) and Western medicine on the traumatic chronic tibial osteomyelitis (CO). A total of 80 patients who were admitted to this hospital between January 2012 and January 2017 were randomly divided into two groups, i.e. Read More

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November 2018

Application of antibiotic impregnated beads on the patients with tibial chronic osteomyelitis.

Pak J Pharm Sci 2018 Nov;31(6(Special)):2783-2786

Department of Orthopedics, Third people's Hospital of Qingdao, Qingdao, Shandong, PR China.

To investigate the clinical efficacy of antibiotic impregnated beads on the tibial chronic osteomyelitis, so as to search for a more applicable method for the treatment. Through comparative analysis, we divided 72 patients with chronic tibial osteomyelitis who received treatment in hospital between January 2016 and December 2016 randomly into two groups: Control group (n=36) and the experiment group (n=36). Patients in the control group underwent closed lavage plus drainage for treatment, while those in the experiment group received the antibiotic impregnated beads. Read More

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November 2018

Current health and economic burden of chronic diabetic osteomyelitis.

Expert Rev Pharmacoecon Outcomes Res 2019 Jan 9:1-8. Epub 2019 Jan 9.

b Department of Foot and Ankle Surgery , Geisinger Community Medical Center , Scranton , PA , USA.

Introduction: Diabetic foot ulcer (DFU) prevalence is as high as 25% and 40-80% of DFUs become infected (DFI). About 20% of infected ulcers will spread to bone causing diabetic foot osteomyelitis (DFO). DFU costs Medicare $9-13 billion/year. Read More

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http://dx.doi.org/10.1080/14737167.2019.1567337DOI Listing
January 2019
3 Reads

serovar Typhi osteomyelitis in a young adult with sickle cell and thalassemia traits: A possible association.

IDCases 2019 24;15:e00478. Epub 2018 Dec 24.

University of Maryland Medical Center Midtown Campus, 827 Linden Avenue, Baltimore, MD, 21201, United States.

osteomyelitis is known to occur in immunocompromised and sickle cell disease patients. It rarely occurs in other hosts. We present a case of chronic femoral osteomyelitis due to serovar Typhi seen in a Maryland resident. Read More

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http://dx.doi.org/10.1016/j.idcr.2018.e00478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317299PMC
December 2018
2 Reads

Acute exacerbation of chronic osteomyelitis triggered by aggravation of type 2 diabetes mellitus: a case report.

J Med Case Rep 2019 Jan 7;13(1). Epub 2019 Jan 7.

Department of General Internal Medicine 1, Kawasaki Medical School, 2-6-1 Nakasange, Kita-ku, Okayama, 700-8505, Japan.

Background: Osteomyelitis is an infection in a bone. Acute osteomyelitis is observed mainly in the long leg bones of children and is usually treated with antibiotics. On the other hand, in adults, subacute or chronic osteomyelitis is more common. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1954-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323657PMC
January 2019
8 Reads

Staphylococcus aureus biofilm organization modulated by YycFG two-component regulatory pathway.

J Orthop Surg Res 2019 Jan 8;14(1):10. Epub 2019 Jan 8.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Disease, Department of Preventive Dentistry, West China Hospital of Stomatology, Sichuan University, No. 14 Renmin South Road, Wuhou District, Chengdu City, 610041, Sichuan, People's Republic of China.

Background: Staphylococcus aureus (S. aureus) infection accounts for more than 50% of the osteomyelitis cases. Currently, methicillin-resistant S. Read More

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https://josr-online.biomedcentral.com/articles/10.1186/s1301
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http://dx.doi.org/10.1186/s13018-018-1055-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325680PMC
January 2019
3 Reads

SAPHO syndrome with enthesopathy.

BMJ Case Rep 2019 Jan 7;12(1). Epub 2019 Jan 7.

Division of Allergy, Immunology & Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome was first described as chronic recurrent multifocal osteomyelitis. Because of its rarity, a thorough description of its clinical manifestations is lacking. Herein, we describe the clinical manifestations and imaging features, especially the enthesopathy in bilateral Achilles tendons, of a middle-aged Asian woman with SAPHO syndrome, who improved after diclofenac treatment. Read More

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http://dx.doi.org/10.1136/bcr-2018-225929DOI Listing
January 2019

The Dilemma of Chronic Recurrent Multifocal Osteomyelitis.

Reumatol Clin 2019 Jan 4. Epub 2019 Jan 4.

Children and Adolescence Unit, Royal National Orthopaedic Hospital, Stanmore, UK.

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare idiopathic inflammatory disease that affects mainly children and young adults, resulting in significant morbidity especially if not diagnosed early. The clinical signs and symptoms are nonspecific, with a consequential delay in diagnosis. Radiological and histopathological criteria are important for its definition. Read More

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http://dx.doi.org/10.1016/j.reuma.2018.10.006DOI Listing
January 2019

The Vertical Contour Calcanectomy: An Alternative Surgical Technique to the Conventional Partial Calcanectomy.

J Foot Ankle Surg 2019 Jan 3. Epub 2019 Jan 3.

Senior Surgeon, Department of Plastic and Reconstructive Surgery, MedStar Georgetown University Hospital, Washington, DC. Electronic address:

Heel ulcers have a significant impact on lower extremity morbidity and confer a high risk for major amputations. Although there are many conservative treatment options, once calcaneal osteomyelitis occurs or a heel ulcer becomes chronic or recalcitrant, more invasive management is required. The partial calcanectomy is a surgical solution that can address both pathologies-the ulceration and the infected bone. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.08.040DOI Listing
January 2019
1 Read

Allogeneic keratinocyte for intractable chronic diabetic foot ulcers: A prospective observational study.

Int Wound J 2019 Jan 2. Epub 2019 Jan 2.

Department of Orthopedic Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Chronic diabetic foot ulcers (DFUs) are a common problem in patients with diabetes and are often difficult to treat. The application of newly developed dressing material in patients with chronic DFUs has been reported to be effective. The purpose of this study was to evaluate the usefulness of allogeneic keratinocyte treatment for chronic DFUs. Read More

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http://doi.wiley.com/10.1111/iwj.13061
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http://dx.doi.org/10.1111/iwj.13061DOI Listing
January 2019
5 Reads

[Discussion on dealing skills of complex soft tissue problems in osteomyelitis treated by Ilizarov technique].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Oct;32(10):1286-1291

No.1 Department of Osteomyelitis, Henan Provincial Luoyang Orthopedic-Traumatological Hospital & Henan Provincial Orthopedic Hospital, Luoyang Henan, 471002, P.R.China.

Objective: To discuss skills for the treatment of complex soft tissue problems in osteomyelitis using Ilizarov techniques.

Methods: The clinical data of 31 patients with complex soft tissue problems during the treatment of osteomyelitis with Ilizarov technique between January 2015 and June 2017 were retrospectively analyzed. There were 23 males and 8 females, with an age of 14-67 years (mean, 37. Read More

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http://dx.doi.org/10.7507/1002-1892.201805055DOI Listing
October 2018
1 Read

Chronic multifocal osteomyelitis: A rare presentation of melioidosis.

J Family Med Prim Care 2018 Sep-Oct;7(5):1133-1135

Department of Medicine, Christian Medical College, Vellore, Tamil Nadu, India.

A 45-year-old gentleman presented with fever, weight loss, and painful swelling of both knees. His history was significant for type 2 diabetes mellitus. Blood cultures grew , and imaging revealed osteomyelitis of bilateral distal femura and proximal tibiae, with no involvement of the joint space. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_227_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259495PMC
January 2019
26 Reads

Chronic mandibular osteomyelitis caused by Granulicatella adiacens in an immunocompetent child.

J Infect Chemother 2018 Dec 27. Epub 2018 Dec 27.

Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan.

We report a pediatric case aged 10 years with Granulicatella adiacens-associated chronic mandibular osteomyelitis. The causative pathogen was uncertain because polymicrobial species were detected from the bacterial culture in bone marrow fluid. In contrast, G. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.12.001DOI Listing
December 2018

In vivo efficacy of tobramycin-loaded synthetic calcium phosphate beads in a rabbit model of staphylococcal osteomyelitis.

Ann Clin Microbiol Antimicrob 2018 Dec 28;17(1):46. Epub 2018 Dec 28.

Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor Darul Ehsan, Malaysia.

Background: Osteomyelitis is an acute or chronic inflammatory process of the bone following infection with pyogenic organisms like Staphylococcus aureus. Tobramycin (TOB) is a promising aminoglycoside antibiotic used to treat various bacterial infections, including S. aureus. Read More

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https://ann-clinmicrob.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12941-018-0296-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309062PMC
December 2018
8 Reads
1.514 Impact Factor

A Case Report of Tuberculosis of Isolated Radial Head A Rare Location with Diagnostic Dilemma.

J Orthop Case Rep 2018 May-Jun;8(3):28-32

Department of Orthopaedics, Assam Medical College and Hospital, Dibrugarh, Assam, India.

Introduction: Tuberculosis (TB) of isolated radial head is scantily reported in the literature. Nonspecific symptoms and difficulty in interpreting initial screening radiographs often lead to misdiagnosis.

Case Report: We present a case of 42-year-old male elsewhere diagnosed as pyogenic arthritis of left elbow and treated by incisional drainage and broad-spectrum antibiotics, who presented to us 6 months later with multiple non-healing actively discharging sinuses. Read More

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http://dx.doi.org/10.13107/jocr.2250-0685.1094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298716PMC
December 2018

Chronic Recurrent Multifocal Osteomyelitis - A Rare Clinical Presentation and Review of Literature.

J Orthop Case Rep 2018 May-Jun;8(3):3-6

Department of Orthopaedics, Government Medical College, Kozhikode, Kerala, India.

Introduction: Chronic recurrent multifocal osteomyelitis (CRMO) is an idiopathic inflammatory disorder of bone seen primarily in children and adolescents. It is part of the clinical picture of non-bacterial osteomyelitis and typically presents a relapsing course with both remissions and spontaneous exacerbations. CRMO is typically seen in the metaphysis of long bones. Read More

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http://dx.doi.org/10.13107/jocr.2250-0685.1082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298712PMC
December 2018
1 Read

Chronic non-bacterial osteomyelitis coexistent with familial Mediterranean fever.

Clin Exp Rheumatol 2018 Nov-Dec;36(6 Suppl 115):150. Epub 2018 Nov 28.

Department of Paediatric Rheumatology, Faculty of Medicine, Gazi University, Ankara, Turkey.

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November 2018
3 Reads

Concurrent chronic recurrent multifocal osteomyelitis and familial Mediterranean fever. A case report.

Clin Exp Rheumatol 2018 Nov-Dec;36(6 Suppl 115):151. Epub 2018 Dec 14.

The Hospital for Sick Children and University of Toronto, Canada.

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December 2018
2 Reads

Secondary amyloidosis associated with heroin use and recurrent infections - A case report.

Authors:
Deepthi Mani

Ann Med Surg (Lond) 2019 Jan 22;37:38-41. Epub 2018 Nov 22.

Multi Care Good Samaritan Hospital, Puyallup, WA, USA.

A 49-year-old lady with history of polysubstance use disorder, recurrent cutaneous abscesses, spinal diskitis and septic thrombophlebitis presented to the emergency room with complaints of intermittent fevers, worsening right hip pain and bilateral lower extremity edema. A month before the presentation, she had left another hospital against medical advice after being diagnosed with Methicillin-resistant bacteremia and right hip septic arthritis. Post discharge, she was off antibiotics, but continued heroin and methamphetamine use. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S20490801183026
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http://dx.doi.org/10.1016/j.amsu.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297111PMC
January 2019
2 Reads

Pott's puffy tumor in children: A review of the literature.

Laryngoscope 2018 Dec 20. Epub 2018 Dec 20.

Department of Ophthalmology, University Hospital of Larissa, Larissa, Greece.

Objectives: Pott's puffy tumor (PTT) is a frontal subperiosteal abscess associated with underlying frontal osteomyelitis. The purpose of the present study was to assess the rate of intracranial involvement in pediatric and adolescent patients with PPT and to discuss the diagnostic workup and the therapeutic features of this pathology.

Methods: We searched Web of Science, PubMed and MEDLINE from 1998 to 2018. Read More

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http://dx.doi.org/10.1002/lary.27757DOI Listing
December 2018

Chronic recurrent osteomyelitis: A surgeon's enigma.

J Oral Pathol Med 2019 Feb 4;48(2):180-184. Epub 2019 Jan 4.

Department of Oral Medicine & Radiology, Manipal College of Dental Sciences, Manipal, Karnataka, India.

Background: Chronic recurrent forms of osteomyelitis of the mandible with their morbid clinical course have long been considered a challenge to maxillofacial surgeons in terms of both diagnosis and treatment. Various classifications and treatments have been established through the ages to define and manage the inflammatory symptoms occurring in adults and children. This paper discusses two such entities occurring in an adult and a child, highlighting the diagnostic and treatment challenges of recurrent osteomyelitis. Read More

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http://dx.doi.org/10.1111/jop.12814DOI Listing
February 2019
1.870 Impact Factor

Antibiotic-Loaded Collagen Sponges in Clinical Treatment of Chronic Osteomyelitis: A Systematic Review.

J Bone Joint Surg Am 2018 Dec;100(24):2153-2161

Department of Orthopaedic Surgery (T.A.G.v.V., J.A.P.G., and J.J.C.A.) and Faculty of Health Medicine and Life Sciences (J.M.B.W.), Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands.

Background: Chronic osteomyelitis is caused by bacterial infection of the bone and is a major problem in orthopaedic surgery. Treatment of chronic osteomyelitis requires surgical debridement accompanied by local and systemic administration of antibiotics. A widely established biodegradable local antibiotic carrier is antibiotic-loaded collagen sponges (fleeces). Read More

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http://dx.doi.org/10.2106/JBJS.17.01140DOI Listing
December 2018

Muscular Versus Non-Muscular Free Flaps for Soft Tissue Coverage of Chronic Tibial Osteomyelitis.

World J Plast Surg 2018 Sep;7(3):294-300

Department of Plastic, Reconstructive and Aesthetic Surgery, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Switzerland.

Background: Eradication of chronic tibial osteomyelitis necessitates aggressive debridement is often followed by soft tissue reconstruction. Muscular flaps are said to be more effective than non-muscular flaps for infection treatment, while fasciocutaneous and perforator flaps are considered to be less invasive and offering a better aesthetic result.

Methods: In this study, we reviewed 24 consecutive cases of chronic tibial osteomyelitis treated according to a specific protocol in a tertiary hospital. Read More

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http://dx.doi.org/10.29252/wjps.7.3.294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290312PMC
September 2018
3 Reads

Host Variability in NTM Disease: Implications for Research Needs.

Front Microbiol 2018 3;9:2901. Epub 2018 Dec 3.

Laboratory of Chronic Airway Infection, Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.

Non-tuberculous mycobacteria (NTM) are ubiquitous environmental organisms that may cause opportunistic infections in susceptible hosts. Lung infections in immunocompetent persons with structural lung disease are most common, while disseminated disease occurs primarily in immunocompromised individuals. Human disease caused by certain species, such as complex, , and , is increasing in incidence and varies by geographic distribution. Read More

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http://dx.doi.org/10.3389/fmicb.2018.02901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286975PMC
December 2018
1 Read

Long Term Follow Up of a Vascularized Osteocutaneous Free Flap for Reconstruction in Charcot Neuroarthropathy: A Case Report.

Ann Plast Surg 2019 Feb;82(2):180-183

Curtis National Hand Center, MedStar Union Memorial Hospital, Baltimore, MD.

Vascularized osteocutaneous free flaps have seen increasing use in foot and ankle surgery for the repair of bony defects secondary to chronic nonunion, osteomyelitis, and fractures. One example is the Medial Femoral Condyle (MFC) Flap. The utility of the MFC flap for the repair of a bony defect in a diabetic patient, however, has yet to be explored. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001670DOI Listing
February 2019
7 Reads

Safety of elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide in HIV-1-infected adults with end-stage renal disease on chronic haemodialysis: an open-label, single-arm, multicentre, phase 3b trial.

Lancet HIV 2018 Dec 13. Epub 2018 Dec 13.

Department of HIV Clinical Research, Gilead Sciences, Foster City, CA, USA. Electronic address:

Background: Current treatment for HIV-infected individuals with renal failure on haemodialysis frequently requires complex regimens with multiple pills. A daily single-tablet regimen of coformulated elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide is approved in Europe, the USA, and in other regions for use in HIV-1-infected individuals with mild-to-moderate chronic kidney disease (creatinine clearance 30-69 mL/min). We aimed to assess the safety, efficacy, and pharmacokinetics of this regimen in HIV-infected adults with end-stage renal disease on chronic haemodialysis. Read More

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http://dx.doi.org/10.1016/S2352-3018(18)30296-0DOI Listing
December 2018
4 Reads

The Role of Free Tissue Transfer in the Management of Chronic Frontal Sinus Osteomyelitis.

Laryngoscope 2018 Dec 14. Epub 2018 Dec 14.

Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.

Objectives/hypothesis: Chronic frontal sinus infection is managed with a combination of medical and surgical interventions. Frontal bone osteomyelitis due to recurrent infection following trauma or prior open surgery may require more significant debridement. Free tissue transfer may allow for extensive debridement with replacement of tissue, and definitive eradication of osteomyelitis. Read More

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http://dx.doi.org/10.1002/lary.27669DOI Listing
December 2018
1 Read

Disease burden and social impact of pediatric chronic nonbacterial osteomyelitis from the patient and family perspective.

Pediatr Rheumatol Online J 2018 Dec 14;16(1):78. Epub 2018 Dec 14.

Pediatric Rheumatology, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.

Background: Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disorder that if left untreated can result in bone destruction and severe continuing pain due to persistent inflammation. The impact this chronic disease has on the daily lives of affected children and their families is not well known. The purpose of this study is to understand the disease burden and socioeconomic and psychological impact of CNO from the patients' and families' perspectives and identify areas of improvement for patient care and reduced disease burden based on patients' and families' responses. Read More

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http://dx.doi.org/10.1186/s12969-018-0294-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295016PMC
December 2018

Infection-free rates and Sequelae predict factors in bone transportation for infected tibia: a systematic review and meta-analysis.

BMC Musculoskelet Disord 2018 Dec 13;19(1):442. Epub 2018 Dec 13.

Department of Orthopedics, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Wuhou District, Chengdu, 610041, Sichuan Province, China.

Background: Tibia infected nonunion and chronic osteomyelitis are challenging clinical presentations. Bone transportation with external or hybrid fixators (combined external and internal fixators) is versatile to solve these problems. However, the infection-free rates of these fixator systems are unknown. Read More

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http://dx.doi.org/10.1186/s12891-018-2363-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293587PMC
December 2018
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Treatment of chronic osteomyelitis with multi-dose oritavancin: a case series and literature review.

Int J Antimicrob Agents 2018 Dec 8. Epub 2018 Dec 8.

Downtown Dublin Wound Center, Meadows Regional Medical Center, Dublin, GA, 31021, USA.

Osteomyelitis remains difficult to treat, typically requiring a prolonged course of intravenous (IV) antibiotics. The optimal route and duration of antibiotics remains ill-defined due to limited prospective clinical trials. Oritavancin is a long acting, semisynthetic, lipoglycopeptide antibiotic with rapid, concentration-dependent bactericidal activity against many Gram-positive organisms. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2018.11.023DOI Listing
December 2018
2 Reads

Histopathological changes in major amputations due to diabetic foot - a review.

Rom J Morphol Embryol 2018 ;59(3):699-702

Discipline of Pharmacology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;

Diabetes mellitus is the leading cause of non-traumatic amputations worldwide. Ulcer of the diabetic foot is one of the most prevalent lesions of diabetic patients and it occurs in the natural evolution of the disease as a tardive complication. Neuropathy is the main determinant of foot ulcer. Read More

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December 2018
3 Reads

Chronic Recurrent Multifocal Osteomyelitis - A Case Series from India.

Indian J Orthop 2018 Nov-Dec;52(6):672-677

Pediatric Rheumatology Clinic, Indira Gandhi Institute of Child Health and Columbia Asia Hospital, Bengaluru, Karnataka, India.

Background: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare auto-inflammatory disease of the bone. It tends to be multifocal and usually the symptoms tend to run for months and years before diagnosis is usually made. The objective of our study was to understand the clinical presentation and short-term response to treatment of CRMO patients. Read More

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http://dx.doi.org/10.4103/ortho.IJOrtho_464_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241066PMC
December 2018
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Chronic skull osteomyelitis due to Cryptococcus neoformans: first case report in an HIV-infected patient.

Braz J Infect Dis 2018 Nov - Dec;22(6):499-502. Epub 2018 Dec 6.

Instituto de Infectologia Emilio Ribas, Departamento de Neurologia, São Paulo, SP, Brazil; Universidade de São Paulo, Hospital das Clínicas da Faculdade de Medicina (HCFM-USP), Departamento de Doenças e Infecciosas, São Paulo, SP, Brazil; Universidade de São Paulo, Instituto de Medicina Tropical, Laboratório de Investigação Médica, São Paulo, SP, Brazil.

Osteomyelitis due to Cryptococcus neoformans are described in mostly 10% of patients with disseminated cryptococcosis, being direct inoculation even more uncommon. We report the case of an HIV-infected patient with history of recurring itching on his scalp and repetitive local trauma. For eighteen months, he noticed a painful and slow growing lump on his scalp. Read More

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http://dx.doi.org/10.1016/j.bjid.2018.11.004DOI Listing
December 2018
3 Reads