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Heliyon 2021 Apr 17;7(4):e06815. Epub 2021 Apr 17.

Department of Radiology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia.

Background: Tuberculous septic arthritis is an infection that occurs inside the joint or synovial fluid and joint tissues caused by . It may show wide variability of clinical symptoms and imaging appearance, ranging from asymptomatic with a normal radiographic examination to severe joint pain along with joint destruction, osteomyelitis, and abscess formation. This article presents radiographic and MR imaging appearance from a case of tuberculous septic arthritis with large abscess formation mimicking soft tissue tumor. Read More

JBMR Plus 2021 May 10;5(5):e10490. Epub 2021 Apr 10.

Centre for Bone Quality, Department of Medicine, Division of Endocrinology Leiden University Medical Center Leiden The Netherlands.

Sternocostoclavicular hyperostosis (SCCH) is a rare autoinflammatory bone disorder caused by chronic nonbacterial osteomyelitis (CNO), which is associated with sclerosis and hyperostosis primarily affecting the sternum, the medial end of the clavicles, and the first ribs. Other areas of the axial skeleton may also be affected. The more severe synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is additionally associated with dermatoses and joint manifestations. Read More

Unfallchirurg 2021 May 10. Epub 2021 May 10.

Klinik und Poliklinik für Unfallchirurgie, Universitätsklinikum Regensburg (UKR), Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Deutschland.

Pyogenic (unspecific) spondylodiscitis and implant-associated vertebral osteomyelitis (IAVO) are important diseases with the risk of neurological and septic complications. An early diagnosis is essential in which magnetic resonance imaging (MRI), histopathology and microbiological identification of the pathogen play key roles. The goals of conservative treatment in uncomplicated spondylodiscitis are antibiotic infection control and pain management. Read More

Foot (Edinb) 2021 Jan 22;47:101781. Epub 2021 Jan 22.

Department of Internal Medicine, PGIMER Dr RML Hospital, New Delhi, India.

Fungal osteomyelitis of calcaneus is rare in immunocompetent adults. A case of fungal osteomyelitis of calcaneus in a 19 year old immunocompetent female without any history of trauma caused by Acremonium sp is presented. The patient was treated with surgical debridement, autogenous iliac crest bone grafting and antifungal chemotherapy for 6 months. Read More

Arch Craniofac Surg 2021 Apr 20;22(2):105-109. Epub 2021 Apr 20.

Department of Plastic and Reconstructive Surgery, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

The use of a fibula osteocutaneous flap is currently the mainstay of segmental mandibular reconstruction. This type of flap is used to treat tumors, trauma, or osteoradionecrosis of the mandible. However, a fibula osteocutaneous flap may also be a good option for reconstructing the mandible to preserve oropharyngeal function and facial appearance in cases of pathological fracture requiring extensive segmental bone resection. Read More

Proc (Bayl Univ Med Cent) 2021 Jan 12;34(3):387-388. Epub 2021 Jan 12.

Department of Internal Medicine, Creighton University, Omaha, Nebraska.

Lemierre's syndrome is a rare disorder characterized by thrombophlebitis of the internal jugular vein and is caused by gram-negative anaerobes, primarily . We report a case of a 20-year-old man who developed chronic osteomyelitis of the femur and myonecrosis of thigh muscles secondary to this syndrome. The diagnosis was made based on clinical presentation and evidence of thrombosis in the internal jugular vein on ultrasound. Read More

Clin Case Rep 2021 Apr 11;9(4):1890-1895. Epub 2021 Mar 11.

Department of Orthopaedic Surgery Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology Tokyo Japan.

Obtaining a correct intraosseous epidermal cyst diagnosis is difficult due to the extreme rarity of this cyst. Further, the clinical manifestations and radiographic findings are very similar to those of a malignancy or infection. Early histopathological analysis is required for accurate diagnosis and for avoiding unnecessary antibiotic administration and amputation. Read More

Med Microbiol Immunol 2021 May 2. Epub 2021 May 2.

Department of Medical Microbiology, Medical University of Warsaw, Chalubinskiego 5 Str, 02-004, Warsaw, Poland.

The aim of the study was to evaluate the pathogenic potential of Bacteroides pyogenes, rarely identified in clinical laboratories anaerobic bacteria. To increase the knowledge about this poorly understood anaerobic microorganism, the study also includes cases of infections described so far in the literature. Only the use of 16S rRNA sequencing and mass spectrometry technique allowed the identification of B. Read More

Int J Pharm 2021 Apr 30;602:120662. Epub 2021 Apr 30.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

High local intraosseous levels of antimicrobial agents are required for adequate long-term treatment of chronic osteomyelitis (OM). In this study, biodegradable composite scaffolds of poly-lactide-co-ε-caprolactone/calcium phosphate (CaP) were in-situ synthesized using two different polymer grades and synthesis pathways and compared to composites prepared by pre-formed (commercially available) CaP for delivery of the antibiotic moxifloxacin hydrochloride (MOX). Phase identification and characterization by Fourier transform infra-red (FTIR) spectroscopy, X-ray powder diffraction (XRPD) and scanning electron microscope (SEM) confirmed the successful formation of different CaP phases within the biodegradable polymer matrix. Read More

Clin Microbiol Infect 2021 Apr 26. Epub 2021 Apr 26.

Department of Microbiology, Amrita Institute of Medical Sciences & Research Centre, Amrita Vishwa Vidyapeetham, Ponekara, Kochi-682041, Kerala India.

Eumycotic mycetoma or eumycetoma is a chronic cutaneous and subcutaneous granulomatous infection caused by various fungi. A 65 year old gentleman presented with a history of nodular swellings on the right foot with discharging sinuses of six years duration. Radiological features showed signs of osteomyelitis. Read More

J Glob Infect Dis 2021 Jan-Mar;13(1):36-37. Epub 2021 Jan 29.

Department of Microbiology, Super Specialty Pediatric Hospital and Postgraduate Teaching Institute, Noida, Uttar Pradesh, India.

Rare and varied presentations of tuberculosis make it difficult for treating clinicians to arrive at the diagnosis. An adolescent female presented to the orthopedic outpatient department with slowly increasing swelling over the dorsum of the hand near the base of the third digit for 5 months. With multiple consultations, she was being treated with antibiotics as a case of abscess. Read More

Medicine (Baltimore) 2021 Apr;100(17):e25703

Department of Orthopaedics, The Affiliated Hospital of Southwest Medical University.

Rationale: Three-dimensional (3D) printing has attracted wide attention for its potential and abilities in the assistance of surgical planning and the development of personalized prostheses. We herewith report a unique case of chronic clavicle osteomyelitis treated with a two-stage subtotal clavicle reconstruction using a 3D printed polyether-ether-ketone (PEEK) prosthesis.

Patient Concerns: A 23-year-old Chinese female presented to our clinic complaining about a progressive pain of her right clavicle for about 1 year. Read More

Cureus 2021 Mar 23;13(3):e14071. Epub 2021 Mar 23.

Medicine, Ministry of Health, Riyadh, SAU.

Tuberculosis is a chronic, infectious disease that predominantly affects the respiratory system. Of the least common extrapulmonary forms of the disease is cutaneous tuberculosis. We present an unusual case, which is of cutaneous tuberculosis in the finger, manifesting as an ulcerating, erythematous lesion. Read More

Pediatr Infect Dis J 2021 Jun;40(6):518-524

From the Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas.

Background: While the majority of pediatric osteomyelitis cases are acute in nature, a significant subset present with prolonged symptoms often associated with substantial morbidity. Little data exist to guide clinicians in the management of these infections. We sought to describe the epidemiology, clinical features and management of chronic osteomyelitis (CO) in children. Read More

J Taibah Univ Med Sci 2021 Apr 19;16(2):177-183. Epub 2020 Nov 19.

Department of Anatomy, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.

Objective: Despite the availability of an extensive array of antibiotics, musculoskeletal infections are not cured successfully. It is necessary to remove sequestra, infected necrotic tissue, and implants. This study was undertaken to assess the efficacy of poly methyl methacrylate (PMMA) beads and identify the variables that influence eradication and recurrence in the treatment of musculoskeletal infections. Read More

Rheumatol Ther 2021 Apr 25. Epub 2021 Apr 25.

Department of Rheumatology, Sir Charles Gairdner Hospital, Perth, Australia.

Objective: To describe the incidence, risk factors and long-term outcomes in children hospitalised with septic arthritis (SA) in Western Australia (WA).

Methods: We extracted state-wide longitudinally linked administrative health data for patients aged < 16 years with a first diagnostic code of 711.X (ICD9-CM) and M00. Read More

Pan Afr Med J 2021 22;38:77. Epub 2021 Jan 22.

Département de Chirurgie, Cliniques Universitaires de Lubumbashi, Faculté de Médecine, Université de Lubumbashi, Lubumbashi, Haut Katanga, République Démocratique du Congo.

Introduction: infections are the leading cause of morbidity and mortality in patients with sickle cell disease, especially before age 5 years. The purpose of this study was to highlight the epidemiological features, etiologies and management of osteoarticular infections in patients with sickle cell disease in Lubumbashi.

Methods: we conducted a descriptive, cross-sectional and retrospective study at the Research Center for Sickle Cell Disease in Lubumbashi (RCSCDL) over a three-year period from June 2014 to June 2017. Read More

J Glob Infect Dis 2020 Oct-Dec;12(4):231-233. Epub 2020 Nov 30.

Division of Infectious Diseases, Veterans Affairs Medical Center, Northport, NY, USA.

is an emerging coagulase-negative regarded as a formidable pathogen capable of causing significant infections at various body sites including bone and joints. We report the case of a Caucasian elderly male with recurrent lumbar osteomyelitis due to . He had a history of chronic low back pain. Read More

Mikrobiyol Bul 2021 Apr;55(2):256-264

University of Health Sciences, Sisli Hamidiye Etfal Research and Training Hospital, Department of Medical Microbiology, Istanbul, Turkey.

Scedosporium apiospermum complex members are opportunistic fungi that can be found in environments such as soil and polluted water. In this report, we aimed to present a case of mycetoma caused by Scedosporium apiospermum complex that developed in a 40-year-old female patient with immunocompetent system and diagnosed by fungal culture. In the anamnesis of the patient who admitted in 2015 with the complaint of more than one fistulized discharge wound, pain and swelling in the dorsal of the right hand and wrist; it was learned that her complaints started about 20 years ago with a slight swelling on the back of the wrist, and when it worsened, the abscess was drained and antibiotic treatment was initiated in a private surgical center. Read More

J Intern Med 2021 Apr 21. Epub 2021 Apr 21.

Nephrology, Dialysis and Renal Transplantation Unit, Grande Ospedaliera Metropolitano, Reggio Cal, Italy.

Chronic kidney failure (CKF) is among the chronic conditions with the highest risk of death. In fact, the life expectancy of these patients is inferior to that of patients with cancers. Protein-energy wasting (PEW) and inflammation (I) are common and usually concurrent conditions in CKF. Read More

Cureus 2021 Mar 17;13(3):e13959. Epub 2021 Mar 17.

Obstetrics and Gynecology, Niger Central Hospital, Niamey, NER.

Sternal osteomyelitis is a rare clinical condition that occasionally develops when there is an adjacent focus of infection. However, primary sternal tubercular osteomyelitis is an extremely rare form. We describe the case of a 52-year-old Indian male who presented with a two-year history of central chest pain. Read More

Microsurgery 2021 Apr 20. Epub 2021 Apr 20.

Department of Plastic Reconstructive Aesthetic Surgery, Osmangazi University, Faculty of Medicine, ESKİŞEHİR, Turkey.

Background: The reverse posterior interosseous artery flap is useful for covering hand defects. However, its major drawback is the short pedicle that limits the reach of the flap up to the metacarpophalangeal level. The authors performed a new modification extending the distal reach of the flap by including the recurrent branch of the posterior interosseous artery and they aimed to present the results of reconstruction with this technique. Read More

Int J Low Extrem Wounds 2021 Apr 20:15347346211003732. Epub 2021 Apr 20.

Vasile GoldisWestern University of Arad, Arad, Romania.

The supposition is that the usage of fibrin rich in leukocytes and platelets advanced (A-PRF) in ulcerative osteomyelitis of the diabetic foot allows rehabilitation from this critical illness. In this investigation, the focus was to normalize the use of platelet-rich fibrin (PRF) in patients with osteomyelitis not amputated, to use this second-generation platelet concentrate as a regeneration enabler. The researchers submitted and utilized A-PRF membranes (1300  × 8 min) in 7 patients (all diabetics) with osteomyelitis and cutaneous injury for 6 months. Read More

J Am Podiatr Med Assoc 2021 Mar;111(2)

Background: Diabetic foot ulcers combined with ischemia and infection can be difficult to treat. Few studies have quantified the level of blood supply and infection control required to treat such complex diabetic foot ulcers. We aimed to propose an index for ischemia and infection control in diabetic chronic limb-threatening ischemia (CLTI) with forefoot osteomyelitis. Read More

J Transl Autoimmun 2021 20;4:100095. Epub 2021 Mar 20.

Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, UK.

Chronic nonbacterial osteomyelitis (CNO) is an inflammatory bone disorder that most frequently affects children and adolescents. Chronic recurrent multifocal osteomyelitis (CRMO) is a severe form of CNO, usually characterized by symmetrical inflammatory bone lesions and its waxing and waning character. Sometimes severe and chronic pain can significantly affect the quality of life and psychosocial development of individuals affected. Read More

Cytokine 2021 Jul;143:155521

Science Research Institute of Phthisiopulmonology, Saint-Petersburg, Russian Federation.

Objectives: Our study aimed to evaluate the cytokine levels in pediatric chronic non-bacterial osteomyelitis (CNO) patients and compare these with other immune-mediated diseases and healthy controls.

Methods: In this prospective study, we included 42 children with CNO, 28 patients with non-systemic juvenile idiopathic arthritis (JIA), 17 children with insulin-dependent diabetes mellitus (IDDM), and 30 healthy age-matched controls. In each of the CNO patients and comparison groups, the levels of 14-3-3-η protein, S100A8/A9 protein, interleukin-4 (IL-4), interleukin-17 (IL-17), interleukin-18 (IL-18), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) were measured by ELISA assay. Read More

Ann Transl Med 2021 Mar;9(6):514

Department of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou, China.

Chronic osteomyelitis is a chronic infectious disease of bone tissue, which can cause necrosis of bone and surrounding soft tissue, and is a common complication of open fracture, internal fixation, diabetic foot and blood-borne bone infection. Traumatic osteomyelitis is caused by bone tissue infection after open fracture surgery or open reduction of fracture or other bone and joint surgery. The lesion is near the fracture end. Read More

Urol Case Rep 2021 Sep 17;38:101640. Epub 2021 Mar 17.

Urology Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India.

Sequestrum formation is a known complication of osteomyelitis. This is usually a source of chronic non resolving infection and inflammation. We present a rare case of pelvic sequestrum following septic arthritis of hip joint invading into the urinary bladder mimicking a bladder calculus and leading to hydroureteronephrosis. Read More

Cureus 2021 Mar 8;13(3):e13765. Epub 2021 Mar 8.

Department of Orthopedics, Prince of Songkhla University, Songkhla, THA.

Tuberculosis (TB) infections of the musculoskeletal system are rare. A 77-year-old female with chronic left elbow pain for five months was treated by irrigation and debridement of the elbow for a presumed diagnosis of septic arthritis. Her pain and wound condition did not improve, and she was referred to our institution. Read More

Am J Med Genet A 2021 Apr 9. Epub 2021 Apr 9.

Department of Internal Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA.

Poikiloderma with neutropenia (PN), is a rare autosomal recessive condition with many associated complications and manifestations. Here we present a patient with confirmed PN who is of one-quarter Chucktaw or Cherokee heritage with no known descent from the Navajo tribe. The patient's condition was complicated by chronic bilateral lower limb cellulitis and associated osteomyelitis which was unresponsive to extensive antibiotic regimens. Read More