Search Our Scientific Publications & Authors

J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Plastic Surgery, University of Virginia Health System.

Appropriate management of lower 3rd molars is crucial to successful treatment of mandibular angle fractures. A unique case of a patient who presented for initial management of a left mandibular angle fracture with an unerupted lower 3rd molar was discussed in this study. After treatment with open reduction and internal fixation of the fracture, the lower 3rd molar erupted and the patient subsequently developed fungal osteomyelitis and hardware failure. Read More

Laryngoscope 2018 Dec 14. Epub 2018 Dec 14.

Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.

Objectives/hypothesis: Chronic frontal sinus infection is managed with a combination of medical and surgical interventions. Frontal bone osteomyelitis due to recurrent infection following trauma or prior open surgery may require more significant debridement. Free tissue transfer may allow for extensive debridement with replacement of tissue, and definitive eradication of osteomyelitis. Read More

Laryngoscope 2018 Dec 14. Epub 2018 Dec 14.

Department of Otolaryngology-Head and Neck Surgery, Petach Tikva, Israel.

Objective: Imaging is important for the diagnosis and follow-up of necrotizing external otitis (NEO). The best imaging modality is controversy. To suggest 2-deoxy-2-[fluorine-18] fluoro-D-glucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) as an alternative to technetium-99m and gallium-67 scans for diagnosis and assessment of response to treatment for patients with NEO. Read More

Pediatr Rheumatol Online J 2018 Dec 14;16(1):78. Epub 2018 Dec 14.

Pediatric Rheumatology, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.

Background: Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disorder that if left untreated can result in bone destruction and severe continuing pain due to persistent inflammation. The impact this chronic disease has on the daily lives of affected children and their families is not well known. The purpose of this study is to understand the disease burden and socioeconomic and psychological impact of CNO from the patients' and families' perspectives and identify areas of improvement for patient care and reduced disease burden based on patients' and families' responses. Read More

BMC Musculoskelet Disord 2018 Dec 13;19(1):442. Epub 2018 Dec 13.

Department of Orthopedics, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Wuhou District, Chengdu, 610041, Sichuan Province, China.

Background: Tibia infected nonunion and chronic osteomyelitis are challenging clinical presentations. Bone transportation with external or hybrid fixators (combined external and internal fixators) is versatile to solve these problems. However, the infection-free rates of these fixator systems are unknown. Read More

Eur J Nucl Med Mol Imaging 2018 Dec 7. Epub 2018 Dec 7.

Department of Trauma Surgery, Utrecht University, University Medical Center Utrecht, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.

Purpose: F-Fluorodeoxyglucose positron emission tomography (F-FDG PET/CT) is frequently used to diagnose fracture-related infections (FRIs), but its diagnostic performance in this field is still unknown. The aims of this study were: (1) to assess the diagnostic performance of qualitative assessment of F-FDG PET/CT scans in diagnosing FRI, (2) to establish the diagnostic performance of standardized uptake values (SUVs) extracted from F-FDG PET/CT scans and to determine their associated optimal cut-off values, and (3) to identify variables that predict a false-positive (FP) or false-negative (FN) F-FDG PET/CT result.

Methods: This retrospective cohort study included all patients with suspected FRI undergoing F-FDG PET/CT between 2011 and 2017 in two level-1 trauma centres. Read More

Mikrobiyol Bul 2018 Oct;52(4):340-347

Inonu University Faculty of Medicine, Department of Orthopaedics and Traumatology, Malatya, Turkey.

Staphylococcus aureus is one of the most clinically important bacteria causing infection in humans. It is an important pathogen in surgical site infections (SSIs), especially after orthopedic surgery. Pantone-valentine leukocidin (PVL) has a great importance in the virulence of S. Read More

Case Rep Pediatr 2018 12;2018:1796831. Epub 2018 Nov 12.

Trauma and Orthopaedics Department, Cambridge University Hospitals Trust, Cambridge, UK.

Pseudoparalysis presenting in infants is a rare manifestation, where infection and trauma are the principle differentials. We present a case of a two-week-old baby boy with pseudoparalysis who was initially diagnosed as Erb's palsy when presented in the emergency department and later re-presented with signs of sepsis. A later diagnosis of osteomyelitis of the humerus and septic arthritis of the shoulder was made. Read More

Infect Drug Resist 2018 26;11:2461-2469. Epub 2018 Nov 26.

Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Purpose: causes serious infections globally, including invasive pneumococcal disease (IPD). We analyze clinical features of pediatric IPD cases identified in China and antibiotic susceptibility of isolated pneumococcal strains.

Methods: Confirmed pediatric IPD patients were prospectively recruited to the study. Read More

Int J Antimicrob Agents 2018 Dec 8. Epub 2018 Dec 8.

Downtown Dublin Wound Center, Meadows Regional Medical Center, Dublin, GA, 31021, USA.

Osteomyelitis remains difficult to treat, typically requiring a prolonged course of intravenous (IV) antibiotics. The optimal route and duration of antibiotics remains ill-defined due to limited prospective clinical trials. Oritavancin is a long acting, semisynthetic, lipoglycopeptide antibiotic with rapid, concentration-dependent bactericidal activity against many Gram-positive organisms. Read More

J Med Imaging Radiat Oncol 2018 Dec 10. Epub 2018 Dec 10.

Department of Nuclear Medicine, Nuclear Medicine, Oncology and Radiotherapy Institute (NORI), Islamabad, Pakistan.

Introduction: The diagnosis of diabetic foot osteomyelitis is crucial and challenging for the proper management of diabetic foot. Tc labelled Ceftizoxime was used as a non-invasive diagnostic agent for diabetic foot osteomyelitis.

Methods: Ceftizoxime [CFT], a third generation cephalosporin, was used in a simple and direct method for the synthesis of TcO labelled infection imaging agent with stannous chloride as reducing agent. Read More

Rom J Morphol Embryol 2018 ;59(3):699-702

Discipline of Pharmacology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;

Diabetes mellitus is the leading cause of non-traumatic amputations worldwide. Ulcer of the diabetic foot is one of the most prevalent lesions of diabetic patients and it occurs in the natural evolution of the disease as a tardive complication. Neuropathy is the main determinant of foot ulcer. Read More

Microbiol Resour Announc 2018 Sep 27;7(12). Epub 2018 Sep 27.

Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA.

Staphylococcus aureus is the causative agent of multiple infections, including bacteremia, infective endocarditis, osteomyelitis, septic arthritis, and prosthetic device infections. We report here the first whole-genome sequence for four S. aureus sequence type 398 isolates from clinical cases of osteomyelitis in four goats with a history of orthopedic surgery. Read More

Indian J Orthop 2018 Nov-Dec;52(6):672-677

Pediatric Rheumatology Clinic, Indira Gandhi Institute of Child Health and Columbia Asia Hospital, Bengaluru, Karnataka, India.

Background: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare auto-inflammatory disease of the bone. It tends to be multifocal and usually the symptoms tend to run for months and years before diagnosis is usually made. The objective of our study was to understand the clinical presentation and short-term response to treatment of CRMO patients. Read More

Dis Aquat Organ 2018 Dec;132(1):79-84

Department of Veterinary Medicine and Animal Productions, University Federico II, 80137, Naples, Italy.

Bacterial bone infections have been occasionally reported in wild sea turtles. This study reports on a sub-adult Caretta caretta affected by Aeromonas hydrophila osteomyelitis, with extensive involvement of cranial and caudal flippers. The turtle was severely debilitated, had limited flipper mobility and showed signs of pain in reaction to manipulation. Read More

Ann Allergy Asthma Immunol 2018 Dec 7. Epub 2018 Dec 7.

Division of Clinical Immunology and Allergy, Children's Hospital Los Angeles; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California. Electronic address:

Braz J Infect Dis 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurology, Instituto de Infectologia Emilio Ribas, São Paulo, SP, Brazil; Department of Infectious Diseases, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, HCFM-USP, São Paulo, SP, Brazil; Laboratory of Medical Investigation, Unit 49, Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, SP, Brazil.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Dec 4. Epub 2018 Dec 4.

Département d'otorhinolaryngologie/chirurgie cervico-faciale/chirurgie de la base du crâne, université Paris-Diderot, hôpital Lariboisière, AP-HP, Paris, France.

Introduction: Chronic invasive fungal rhinosinusitis (CIFR) is a rare entity generally observed in immunodepressed subjects. The pathogen most frequently identified is Aspergillus spp. Imaging generally reveals invasive pseudoneoplastic features. Read More

J Microbiol Methods 2018 Dec 7;156:60-67. Epub 2018 Dec 7.

Division of Pediatric Infectious Diseases, Children's Hospital Colorado, 13123 East 16th Avenue, Aurora, CO 80045, USA. Electronic address:

Background: Pathogen detection in pediatric patients with musculoskeletal infections relies on conventional bacterial culture, which is slow and can delay antimicrobial optimization. The ability to rapidly identify causative agents and antimicrobial resistance genes in these infections may improve clinical care.

Methods: Convenience specimens from bone and joint samples submitted for culture to Children's Hospital Colorado (CHCO) from June 2012 to October 2016 were evaluated using a "Musculoskeletal Diagnostic Panel" (MDP) consisting of the Xpert MRSA/SA SSTI real-time PCR (qPCR, Cepheid) and laboratory-developed qPCRs for Kingella kingae detection and erm genes A, B, and C which confer clindamycin resistance. Read More

Semin Ultrasound CT MR 2018 Dec 15;39(6):587-604. Epub 2018 Nov 15.

Section of Neuroradiology, University of Cincinnati Medical Center, Cincinnati, OH. Electronic address:

Infectious processes of the spine are on the rise; in this scenario recognition of entities imitating infection is very important. The discovertebral unit is regarded as one of the most important and active sites in the spine. Importantly, the vertebral bony rim and the anterior corners of the vertebral bodies have significant vascularization, they are the last regions to ossify in the developmental process and suffer mechanical forces. Read More

BMC Infect Dis 2018 Dec 7;18(1):635. Epub 2018 Dec 7.

Infectious Diseases Unit, Hospital Universitario Central de Asturias (HUCA), Oviedo University School of Medicine, Oviedo, Spain.

Background: Osteomyelitis is a difficult-to-cure infection with a high relapse rate despite combined medical and surgical therapies. Some severity factors, duration of antimicrobial therapy and type of surgical procedure might influence osteomyelitis relapse.

Methods: 116 patients with osteomyelitis were followed for ≥1 year after hospital discharge. Read More

Acta Ortop Mex 2018 May-Jun;32(3):182-187

Hospital Centro Médico de Occidente. Instituto Mexicano del Seguro Social (IMSS). Guadalajara, Jalisco. México.

The term «vertebral destruction syndrome» comprises pathologies causing structural changes in the spine, mainly in the vertebral body, producing mechanical deformity and neurological involvement. The pathologies found in this definition may be infectious, metabolic or tumoral. Vertebral osteomyelitis is a disease that occurs mainly in adults > 50 years; we speak of spondylodiscitis when the condition affects the disc and vertebral body. Read More

J Am Acad Orthop Surg 2018 Dec 4. Epub 2018 Dec 4.

From the Department of Orthopaedics (Dr. R. F. Murphy, Dr. Plumblee, Dr. Barfield, and Dr. Dow), Medical University of South Carolina, Charleston SC, Children's Orthopaedics of Atlanta, Atlanta, GA (Dr. J. S. Murphy, Mr. Fuerstenau), the Department of Orthopaedics and Biomedical Engineering, University of Tennessee-Campbell Clinic, Memphis, TN (Dr. Spence and Dr. Kelly), and Shriner's Hospital for Children, Springfield, MA (Dr. Mooney).

Introduction: Septic arthritis of the hip (SAH) is a common condition encountered by pediatric orthopaedic surgeons and is treated with arthrotomy and irrigation. Depending on the response to initial treatment, some patients require surgical treatment beyond the index procedure. The purpose of this study was to investigate risk factors for repeat surgical intervention after initial arthrotomy for presumed SAH. Read More

J Am Acad Orthop Surg 2018 Dec 4. Epub 2018 Dec 4.

From the Department of Orthopaedics, Beaumont Health System, Royal Oak, MI.

Cutibacterium acnes, long thought to be skin flora of pathological insignificance, has seen a surge in interest for its role in spine pathology. C acnes has been identified as a pathogen in native spine infection and osteomyelitis, which has implications in the management compared with more commonly recognized pathogens. In addition, It has also been recognized as a pathogen in postoperative and implant-associated infections. Read More

Skeletal Radiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Radiology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo, 157-8535, Japan.

Pelvic osteomyelitis may occur in a metaphyseal equivalent, defined as a portion of flat or irregular bone that is adjacent to cartilage. The pelvic bone is known to have several metaphyseal equivalents and of these, the sacroiliac joint is the most frequent site of involvement. However, a sacral neurocentral synchondrosis has not been recognized as a metaphyseal equivalent, and there have been no previous reports describing this as the site of origin of sacral osteomyelitis. Read More

Poult Sci 2018 Dec 3. Epub 2018 Dec 3.

Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA.

Bacterial chondronecrosis with osteomyelitis (BCO) is a leading cause of lameness in broilers. Infrared thermography (IRT) is a noninvasive technique for measuring infrared radiation from an object and can be used to evaluate clinical health. Two replicated studies compared the effect of light intensity on broilers grown on a wire flooring model that experimentally increased their susceptibility to and incidence of BCO lameness. Read More

J Surg Case Rep 2018 Nov 27;2018(11):rjy319. Epub 2018 Nov 27.

Black Country Vascular Unit, The Dudley Group NHS Foundation Trust, Dudley, UK.

We describe a case of osteomyelitis in a patient with spina bifida presenting to the vascular surgeon and highlight the complex challenges encountered. We review the literature and demonstrate how good multidisciplinary care and early consideration for surgical amputation may benefit this unique group of patients. Read More

World J Nucl Med 2018 Oct-Dec;17(4):286-292

Department of Oncology and Nuclear Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.

The aim of this study was to evaluate the additive value of technetium methylene diphosphonate (Tc-MDP) hybrid single-photon emission computed tomography/computed tomography (SPECT-CT) in the diagnosis of skull base osteomyelitis (SBO) compared to planar bone scintigraphy (PBS). This was a single institution; prospective study included 23 patients with otitis externa, clinically suspected of SBO, all of them were diabetic. Three-phase bone scintigraphy and SPECT/CT were performed to all patients. Read More

Reumatologia 2018 31;56(5):328-332. Epub 2018 Oct 31.

Clinic of Rheumatology, UMHAT St. Ivan Rilski University Hospital, Sofia, Bulgaria.

Infectious spondylodiscitis is characterized by vertebral osteomyelitis, spondylitis, and discitis. Patients present with persistent low back pain, fever, or neurological findings. Diagnosis is made with a combination of clinical, radiological, and laboratory findings. Read More

Eur J Clin Pharmacol 2018 Dec 4. Epub 2018 Dec 4.

Faculty of Health and Medical Sciences, Harry Perkins Research Institute, Fiona Stanley Hospital, University of Western Australia, PO Box 404, Bull Creek 6149, Murdoch, Western Australia, Australia.

Purpose: Ertapenem is used off-label to treat osteoarticular infections but there are few pharmacokinetic (PK) data to guide optimal dosing strategies in patients who may be obese with multiple co-morbidities including diabetes and peripheral vascular disease.

Methods: Participants undergoing lower limb amputation or elective joint arthroplasty received a dose of intravenous ertapenem prior to surgery. Eight plasma samples were collected over 24 h, together with at least one bone sample per patient. Read More

J Oral Maxillofac Surg 2018 Dec 12;76(12):2551-2558. Epub 2018 Jun 12.

Associate Professor, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA. Electronic address:

Purpose: To review cases of suppurative osteomyelitis of the jaws treated at the Massachusetts General Hospital (Boston, MA) over a 10-year period, evaluate specifics of disease presentation, and answer the clinical question: are there identifiable variables associated with treatment outcome?

Materials And Methods: A retrospective cohort study was completed using patients treated for suppurative osteomyelitis of the jaws at the Massachusetts General Hospital from April 2006 to October 2016. Inclusion criteria were a diagnosis of suppurative osteomyelitis of the jaw, age older than 18 years, and complete medical records. Patients with nonsuppurative disease, radiation history, or antiresorptive exposure were excluded. Read More

Spine J 2018 Nov 27. Epub 2018 Nov 27.

Department of Infectious Diseases, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju, 61469, Republic of Korea. Electronic address:

Background Context: Postoperative vertebral osteomyelitis (PVO) after spinal surgery is a clinical challenge. However, there is a paucity of evidence regarding the most likely etiologic organisms to guide the choice of empirical antibiotic therapy, and previous reports of treatment outcomes for PVO are scarce.

Purpose: To compare the microbiology, clinical characteristics, and outcomes of pyogenic PVO with native vertebral osteomyelitis (NVO). Read More

Clin Imaging 2018 Nov 15;54:15-20. Epub 2018 Nov 15.

Department of Radiology, University of Florida, Gainesville, FL, United States of America.

Differentiation of bone infarct from osteomyelitis is one of the most challenging issues in the evaluation of acute bone pain in sickle cell patients. The imaging modalities that are currently being used for assessment of bone marrow in this population have several limitations. We present a case of an 18-year-old male with a history of sickle cell disease, who was transferred to our emergency department with progressively severe headache and jaw pain for one-week. Read More

Bone Joint J 2018 Dec;100-B(12):1542-1550

Department of Trauma Surgery, University of Utrecht, University Medical Centre Utrecht (UMCU), Utrecht, Netherlands.

Aims: To assess the diagnostic value of C-reactive protein (CRP), leucocyte count (LC), and erythrocyte sedimentation rate (ESR) in late fracture-related infection (FRI).

Materials And Methods: PubMed, Embase, and Cochrane databases were searched focusing on the diagnostic value of CRP, LC, and ESR in late FRI. Sensitivity and specificity combinations were extracted for each marker. Read More

Case Rep Orthop 2018 25;2018:6374784. Epub 2018 Oct 25.

Department of Orthopaedics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Tuberculous distal biceps tendon rupture is a rare condition in orthopedics. Musculoskeletal tuberculosis usually presents with bursitis, synovitis, myositis, and osteomyelitis, conditions which demonstrate an excellent response to antituberculosis chemotherapy. Tendon rupture is often associated with delayed diagnosis and treatment. Read More

Int J Paleopathol 2018 Nov 26;24:185-196. Epub 2018 Nov 26.

Centre for GeoGenetics, Natural History Museum, Øster Voldgade 5-7, 1350, Copenhagen, Denmark. Electronic address:

The skeletal remains of the young female (20-24 years) from Grave JP/106, discovered in the Southern Suburb of the Břeclav - Pohansko Stronghold (Early Middle Ages, 9th century-beginning of the 10 century, present day Czech Republic) display several noteworthy pathologies. The first is deformation of the mandible, which was most probably caused by a fracture of the ramus in combination with a subcondylar fracture. The spine of this young woman also exhibits a probable traumatic injury of the cervical spine in combination with a slowly growing structure situated inside the spinal canal, which caused deformation centered upon C7. Read More

Clin Spine Surg 2018 Nov 26. Epub 2018 Nov 26.

Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Study Design: This is a retrospective cohort study.

Objective: This study's objective was to determine whether perioperative invasive vascular catheter placement, independent of comorbid conditions, modified the risk of postoperative infection in lumbar spine surgery.

Summary Of Background Data: Infection is a risk inherent to lumbar spine surgery, with overall postoperative infection rates of 0. Read More

Eur J Rheumatol 2018 Oct 12. Epub 2018 Oct 12.

Department of Pediatric Medicine, Kolkata Medical College, Kolkata, India.

Objective: Musculoskeletal manifestations in children infected with human immunodeficiency virus (HIV) are responsible for increased morbidity and decreased quality of life. Even in this era of highly active anti-retroviral therapy (HAART), there are limited studies on different rheumatological manifestations in pediatric patients with HIV, and the spectrum of musculoskeletal manifestation in pediatric HIV is yet to be established.

Methods: A single-center, prospective, observational study was carried out from October 2014 to September 2016 in a tertiary care hospital of Eastern India with 517 children infected with HIV aged between 3 and 19 years. Read More

Future Microbiol 2018 Nov 29. Epub 2018 Nov 29.

U1047, INSERM, University Montpellier, Department of Microbiology, University Hospital Nimes, Nîmes, France.

Aim: We evaluated the performance of Unyvero implant and tissue infections system (ITI) application (Curetis) to diagnose Diabetic Foot Osteomyelitis (DFOM).

Patients & Methods: The study was conducted in the Diabetic Foot reference center of Nîmes University Hospital (France) from 1 December 2016 to 31 May 2017. We compared the Unyvero ITI PCR to conventional culture and alternative molecular approaches. Read More

Urol Int 2018 Nov 28:1-5. Epub 2018 Nov 28.

Department of Obstetrics and Gynecology, Division of Urogynecology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey.

Sacrocolpopexy is the gold standard treatment for apical compartment prolapse with reported success rates of 78-100%. Spondylodiscitis is a rare complication of sacrocolpopexy and includes a spectrum of spinal infections such as discitis, osteomyelitis, epidural abscess, meningitis, subdural empyema, and spinal cord abscess. Here we report a case of spondylodiscitis following laparoscopic sacrocolpopexy with long-term follow-up and discuss management of spondylodiscitis after abdominal sacrocolpopexy, with a review of the literature. Read More

Oral Radiol 2018 Nov 15. Epub 2018 Nov 15.

Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Adenoid cystic carcinoma (ACC) is a rare epithelial tumor of the head and neck region, and one of the most common malignant tumors of the salivary glands. ACC is a slow-growing tumor characterized by perineural invasion and often has a high-recurrence rate. We describe a case of oropharyngeal ACC invading the mandibular bone through the mandibular foramen that showed a rare pattern of origin and invasion. Read More

Dermatol Pract Concept 2018 Oct 31;8(4):297-298. Epub 2018 Oct 31.

Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, Germany.

Pediatr Rheumatol Online J 2018 Nov 22;16(1):74. Epub 2018 Nov 22.

Departments of Paediatric Rheumatology and Immunology, Bristol Royal Hospital for Children, Bristol, BS2 8BJ, UK.

Objective: To understand the demographics, clinical features and treatment outcomes of Chronic Non-bacterial Osteitis (CNO) from three tertiary paediatric rheumatology services in the United Kingdom.

Methods: Children less than 18 years of age diagnosed with CNO between 2001 to 2016 from one tertiary service and between 2001 to 2017 from two tertiary services were included. Clinical notes were reviewed and all pertinent data were collected on a pre-defined proforma. Read More

Arch Plast Surg 2018 Nov 15;45(6):601-604. Epub 2018 Nov 15.

Department of Plastic and Reconstructive Surgery, Myongji Hospital, Goyang, Korea.

Arch Plast Surg 2018 Nov 15;45(6):564-571. Epub 2018 Nov 15.

Department of Plastic and Reconstructive Surgery, Sanggye Paik Hospital, Inje University School of Medicine, Seoul, Korea.

Background: Chronic wounds occur due to failure of the normal healing process, associated with a lack of deposition of cellular components and a suitable microenvironment such as the extracellular matrix (ECM). Acellular dermal matrix (ADM) is viewed as an ECM substitute, and a paste-type ADM has recently been introduced. We hypothesized that CGPaste, an injectable paste-type ADM, could serve as a scaffold and promote wound healing. Read More

J Bone Miner Metab 2018 Nov 22. Epub 2018 Nov 22.

Department of Advanced Biomaterials, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan.

Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse effect of antiresorptive agents like bisphosphonates. Abnormal concentrations of various trace metallic elements contained in bone minerals have been associated with MRONJ. In this study, we focused on trace metallic elements contained in the MRONJ sequestrum; their content and distribution were compared to those in osteomyelitis and non-inflammatory bones using inductively coupled plasma atomic emission spectroscopy (ICP-AES) and synchrotron radiation X-ray fluorescence analysis (SR-XRF). Read More

Indian J Otolaryngol Head Neck Surg 2018 Dec 18;70(4):549-554. Epub 2018 Jun 18.

Sri Guru Ram Das Institute of Health Sciences and Research Amritsar, 27-C; Sant Avenue, The Mall, Amritsar, 143001 India.

Malignant Otitis externa is a necrotizing condition of external ear involving causing the osteomyelitis of the bone and surrounding soft tissue leading to multiple cranial nerve palsies. Though most patients respond to oral ciprofloxacin but due to emerging resistance cases of refractory malignant otitis externa which are unresponsive to antibiotic therapy for at least 6 weeks are being encountered lately. A study of 20 patients of refractory malignant otitis Externa was conducted at a tertiary care centre in north India; 10 patients were randomly allotted in group A and group B each. Read More

Acta Orthop Belg 2018 Jun;84(2):184-191

Joint degeneration may make a total knee replacement a requirement for pain relief and function, however the presence of adjacent osteomyelitis makes management extremely challenging. We describe a series of four patients with a mean age of 50 with multi-organism osteomyelitis who underwent single-stage total knee replacements at an average of 63 months following eradication. Three patients did well but had complications associated with poor skin and soft tissues, and abnormal bone anatomy. Read More

Pediatr Emerg Care 2018 Nov 19. Epub 2018 Nov 19.

Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Leukemia is the most common childhood malignancy, and it is often characterized by pallor, fatigue, cytopenia, and organomegaly; sometimes musculoskeletal symptoms, mainly characterized by diffuse bone pain in the lower extremities, are the onset clinical characteristics of the disease. In these cases, the disease may initially be misdiagnosed as reactive arthritis, osteomyelitis, or juvenile idiopathic arthritis delaying appropriate diagnosis and management. Even if leukopenia, thrombocytopenia, and a history of nighttime pain are reported to be the most important predictive factors for a pediatric leukemia, blood examinations can sometimes be subtle or within normal limits, and this represents a further diagnostic difficulty. Read More

Int J Low Extrem Wounds 2018 Nov 21:1534734618810944. Epub 2018 Nov 21.

2 Baylor College of Medicine, Houston, TX, USA.

Recent studies have shown an association between infections, such as influenza, pneumonia, or bacteremia, and acute cardiac events. We studied the association between foot infection and myocardial infarction, arrhythmia, and/or congestive heart failure. We analyzed the records of 318 consecutive episodes of deep soft tissue infection, gangrene, and/or osteomyelitis in 274 patients referred to a vascular surgery service at a tertiary center. Read More