6,686 results match your criteria Osteomyelitis Chronic


Assessment of inflammatory jaw pathologies using bone SPECT-CT maximum standardized uptake value.

Dentomaxillofac Radiol 2020 Jun 3:20200043. Epub 2020 Jun 3.

Quantitative Diagnostic Imaging, Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics, Course of Applied Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata, Niigata, Japan.

Objective: To investigate the assessment of inflammatory jaw pathologies using bone single-photon emission computed tomography-computed tomography (SPECT-CT) maximum standardized uptake value (SUV).

Methods: Forty-four patients with inflammatory jaw pathologies (seven chronic osteomyelitis, 8 osteoradionecrosisand 29 medication-related osteonecrosis of the jaw (MRONJ)) underwent SPECT-CT at 4 h after injection of Tc hydroxymethylene diphosphonate. The SPECT-CT parameters SUV of the inflammatory jaw pathologies were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1259/dmfr.20200043DOI Listing

Treatment of femoral defective osteomyelitis with minimal invasive plates.

Trauma Case Rep 2020 Aug 22;28:100317. Epub 2020 May 22.

Fethiye Letoon Hospital Department of Orthopedics and Traumatology, Turkey.

Although recent treatment modalities reduced chronic osteomyelitis, it is still a challenging problem for both orthopaedic surgeons and patients. Especially treatment of femoral osteomyelitis with defective nonunion is reasonably difficult. Most accepted treatment option is external fixation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tcr.2020.100317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256327PMC

Brodie's Abscess Masquerading as Vaso-occlusive Crisis in a Sickle-cell Disease Patient.

Cureus 2020 Apr 28;12(4):e7871. Epub 2020 Apr 28.

Internal Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, USA.

Brodie's abscess is a rare form of subacute osteomyelitis, most commonly found in children between the ages of two to fifteen years. It has slight preponderance for males. It is characterised by centrally placed, well-circumscribed abscess within the medulla or metaphysis of long bone, most commonly tibia, surrounded by a sclerotic wall. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255565PMC

Single-stage treatment of chronic localized tibial osteomyelitis with local debridement and antibiotic-loaded calcium sulfate implantation: a retrospective study of 42 patients.

J Orthop Surg Res 2020 Jun 1;15(1):201. Epub 2020 Jun 1.

Department of Orthopaedics and Traumatology, Guangdong Second Provincial General Hospital, Guangzhou, 510317, People's Republic of China.

Background: Although various methods have been introduced, the management of chronic tibial osteomyelitis remains a challenge. This study aims to assess a combined treatment method, local debridement combined with antibiotic-loaded calcium sulfate implantation, for the management of the local (Cierny-Mader type III) tibial osteomyelitis.

Methods: Forty-two patients (43 limbs) with type III tibial osteomyelitis, from January 2012 to December 2018, who received the treatment method mentioned above were included in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13018-020-01721-7DOI Listing

Pamidronate in chronic non-bacterial osteomyelitis: a randomized, double-blinded, placebo-controlled pilot trial.

Scand J Rheumatol 2020 Jun 2:1-11. Epub 2020 Jun 2.

Department of Rheumatology, Aarhus University Hospital , Aarhus, Denmark.

Objective: This is the first randomized double-blinded, placebo-controlled pilot trial to investigate the efficacy of pamidronate in reducing radiological and clinical disease activity in chronic non-bacterial osteomyelitis (CNO).

Method: Patients received pamidronate or placebo at baseline and weeks 12 and 24. Whole-body magnetic resonance imaging was performed at baseline and weeks 12 and 36, and computed tomography of the anterior chest wall (ACW) at baseline and week 36. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/03009742.2020.1724324DOI Listing

Case of mucormycosis of mandible after self-extraction of teeth incidentally detected to have chronic granulomatous disease: Case report and literature review.

Med Mycol Case Rep 2020 Jun 11;28:55-59. Epub 2020 Apr 11.

Department of Medicine, All India Institute of Medical Science, New Delhi, 110029, India.

Mucormycosis isolated to the mandible is a rare presentation occurring generally after dental procedures. The case we report presented with discharging sinuses over facial region with radiological appearance of isolated osteomyelitis of the mandible. The patient used to apply an addictive dental powder over his teeth leading to caries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mmcr.2020.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248539PMC

[Giant temporal bone cholesteatoma].

Vestn Otorinolaringol 2020 ;85(2):55-57

V.V. Banykin Tolyatti City Clinical Hospital No. 2, Department of Otorhinolaryngology, Tolyatti, Russia.

Presented clinical observation of a patient with exacerbation of left-sided chronic purulent otitis media complicated by extradural brain abscess, temporal bone osteomyelitis. The patient underwent a sanitizing operation on the left temporal bone with plastic closure of the defect in the postoperative cavity with a muscular-fascial flap. Described the postoperative management of the patient and presented the results of treatment 2 months after surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17116/otorino20208502155DOI Listing
January 2020

Mycobacterium abscessus-associated vertebral osteomyelitis in an immunocompetent patient: a rare case report and literature review.

Spinal Cord Ser Cases 2019 May 31;5(1):53. Epub 2019 May 31.

Division of Orthopedic Surgery, Albany Medical College, Albany, NY, USA.

Introduction: Vertebral osteomyelitis (VO) is an uncommon infection with Staphylococcus aureus as the most commonly implicated organism. VO caused by nontuberculous mycobacteria (NTM) such as Mycobacterium abscessus (M. abscesscus) is exceedingly rare with only eight cases reported in literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41394-019-0197-5DOI Listing

Chronic recurrent multifocal osteomyelitis with myositis: A case report and review of the literature.

Pediatr Int 2020 May;62(5):644-645

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ped.14144DOI Listing

Orofacial tuberculosis: A diagnostic challenge.

IDCases 2020 15;21:e00825. Epub 2020 May 15.

Oral and Maxillofacial Surgery Board Resident, Department of Oral and Maxillofacial Surgery, Medical City Complex, Bab Al Muadham, 10047, Baghdad, Iraq.

Tuberculosis is typically a pulmonary chronic infectious disease with a high prevalence in developing countries which carries a substantial rate of mortality. Extrapulmonary disease may occur, mainly second to the endogenous spread of the pathogen from the primary site. Oral or mandibular involvement represents a minority among the reported cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.idcr.2020.e00825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242870PMC

Osteomyelitis: an Unusual Pathogen which Highlights the Importance of Deep Tissue Sampling in Chronic Osteomyelitis.

J Bone Jt Infect 2020 30;5(2):96-100. Epub 2020 Mar 30.

Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Windmill Road, Oxford, OX3 7HE, UK.

, named following its identification in human corpses, is an unusual pathogen. We report the first case of osteomyelitis. This case highlights the importance of deep tissue sampling and appropriate culture to correctly identify causative pathogens and guide targeted antimicrobial therapy in difficult-to-treat infections like chronic osteomyelitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/jbji.43801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242405PMC

Tigecycline Versus Colistin in the Treatment of Carbapenem-resistant Complex Osteomyelitis.

J Bone Jt Infect 2020 21;5(2):60-66. Epub 2020 Feb 21.

Instituto de Ortopedia e Traumatologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil.

: complex is an increasingly important cause of osteomyelitis. It is considered a difficult to treat agent, due to increasing antimicrobial resistance and few available therapeutic options. : To compare effectiveness and tolerability of tigecycline and colistin in patients with osteomyelitis caused by carbapenem-resistant complex (CRABC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/jbji.42448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242406PMC
February 2020

Calvarial tuberculosis presenting with skin defect in an elderly patient.

World Neurosurg 2020 May 16. Epub 2020 May 16.

Department of Pathology, Yeungnam University Hospital, Yeungnam University College of Medicine Daegu, Republic of Korea.

Background: Tuberculosis is a common disease; however, the prevalence of calvarial tuberculosis is very rare. Most cases of calvarial tuberculosis occur in young patients.

Case Description: We report a rare case of calvarial tuberculosis in an elderly patient. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2020.05.076DOI Listing

The successful use of a bespoke OssDsign cranial plate to reconstruct an occipital defect following excision of a recurrent epithelioid sarcoma.

JPRAS Open 2020 Jun 25;24:71-76. Epub 2020 Feb 25.

The Craniofacial Unit, Department of Plastic Surgery, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom.

A cranioplasty has a number of known associated complications including infection for non-biological implants and bone flap resorption where autologous grafts are used. In recent years, bioactive ceramic cranial implants have been developed as a new reconstructive option. The OssDsign cranial plate (OssDsign AB, Uppsala, Sweden) was first introduced in 2010 and consists of an interconnected mosaic of hydroxyapatite tiles mounted onto a 3D-printed titanium mesh. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpra.2020.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225370PMC

[Advances in clinical diagnosis and treatment of chronic osteomyelitis in adults].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2020 May;34(5):651-655

Department of Trauma and Hand Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning Guangxi, 530021, P.R.China.

Objective: To review the progress of clinical diagnosis and treatment of chronic osteomyelitis in adults.

Methods: The literature related to chronic osteomyelitis in recent years was extensively reviewed, and the clinical diagnosis and treatment methods were summarized.

Results: Clinical characteristics and laboratory examination can help to diagnose chronic osteomyelitis in adults. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7507/1002-1892.201909032DOI Listing

Pediatric Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis (SAPHO) Syndrome: Diagnostic Challenges and Treatment Approach.

Cureus 2020 Apr 9;12(4):e7595. Epub 2020 Apr 9.

Orthopaedics, Panagiotis & Aglaia Kyriakou Children's Hospital, Athens, GRC.

Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome is a rare disease; however, more and more case reports have been published that increase the awareness of this disorder, especially in children. Clinically it presents as a combination of chronic recurrent multifocal osteomyelitis symptoms and skin manifestations. SAPHO treatment remains a challenge. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213676PMC

Genetic variants in FBLIM1 gene do not contribute to SAPHO syndrome and chronic recurrent multifocal osteomyelitis in typical patient groups.

BMC Med Genet 2020 May 12;21(1):102. Epub 2020 May 12.

Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schwabachanlage 10, 91054, Erlangen, Germany.

Background: Syndrome of synovitis acne pustulosis hyperostosis osteitis (SAPHO) and chronic recurrent multifocal osteomyelitis (CRMO) present two diseases of a dermatologic and rheumatologic spectrum that are variable in manifestation und therapeutic response. Genetic risk factors have long been assumed in both diseases, but no single reliable factor has been identified yet. Therefore, we aimed to clinically characterize a patient group with syndrome of synovitis acne pustulosis hyperostosis osteitis (SAPHO) (n = 47) and chronic recurrent multifocal osteomyelitis (CRMO)/ chronic non-bacterial osteomyelitis (CNO) (n = 9) and analyze a CRMO candidate gene. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12881-020-01037-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216525PMC

PYED-1 Inhibits Biofilm Formation and Disrupts the Preformed Biofilm of .

Antibiotics (Basel) 2020 05 8;9(5). Epub 2020 May 8.

Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.

Pregnadiene-11-hydroxy-16α,17α-epoxy-3,20-dione-1 (PYED-1), a heterocyclic corticosteroid derivative of deflazacort, exhibits broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria. Here, we investigated the effect of PYED-1 on the biofilms of , an etiological agent of biofilm-based chronic infections such as osteomyelitis, indwelling medical device infections, periodontitis, chronic wound infections, and endocarditis. PYED-1 caused a strong reduction in biofilm formation in a concentration dependent manner. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/antibiotics9050240DOI Listing

Three-Dimensional Printed Cage in Patients With Tibiotalocalcaneal Arthrodesis Using a Retrograde Intramedullary Nail: Early Outcomes.

Foot Ankle Spec 2020 May 11:1938640020920947. Epub 2020 May 11.

Division of Sports Medicine, Department of Orthopaedic Surgery, University of Illinois at Chicago, Illinois (LBP).

. Segmental bone loss in the hindfoot hinders the chance of successful outcomes. Tibiotalocalcaneal arthrodesis is a reliable option; nevertheless, the risk of nonunion is high. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1938640020920947DOI Listing

Chronic non-bacterial osteomyelitis and autoinflammatory bone diseases.

Clin Immunol 2020 May 7;216:108458. Epub 2020 May 7.

Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, United States of America. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2020.108458DOI Listing

Risk factors affecting amputation in diabetic foot.

Yeungnam Univ J Med 2020 May 6. Epub 2020 May 6.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, Korea.

Background: A diabetic foot is the most common cause of non-traumatic lower extremity amputations (LEA). The study seeks to assess the risk factors of amputation in patients with diabetic foot ulcers (DFU).

Methods: The study was conducted on 351 patients with DFUs from January 2010 to December 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12701/yujm.2020.00129DOI Listing

Closed Incisional Negative Pressure Wound Therapy at Flap Suture Line: An Innovative Approach for Improving Outcomes in Suboptimal Wound Conditions.

Indian J Plast Surg 2020 Mar 8;53(1):90-96. Epub 2020 Apr 8.

Department of Plastic Reconstructive & Burns Surgery, All India Institute of Medical Sciences, New Delhi, India.

 Persistent dead space following flap cover is a frequently encountered challenge following the reconstruction of complex wounds. It may lead to a hematoma, seroma, wound infection, and wound dehiscence. Wound dehiscence could be a devastating complication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1709528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192709PMC

Infected Schmorl's node: a case report.

BMC Musculoskelet Disord 2020 May 2;21(1):280. Epub 2020 May 2.

Department of Neurosurgery, Nanoori Hospital Gangnam, 731, Eonju-ro, Gangnam-gu, Seoul, 06048, Republic of Korea.

Background: Schmorls node (SN) are mostly asymptomatic and incidental findings on MRI. However, sometimes they present like acute onset low back pain or acute exacerbation of chronic back pain after minor trauma.

Case Presentation: We present rare case of symptomatic infected SN in 67 years female patient presented with complains of low back pain radiating to right buttock. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12891-020-03276-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196219PMC
May 2020
1.898 Impact Factor

Quantification of Disease Activity in Chronic Nonbacterial Osteomyelitis by Whole-body Magnetic Resonance Imaging.

J Rheumatol 2020 May;47(5):646-649

Department of Radiology, Aarhus University Hospital, Aarhus, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3899/jrheum.191136DOI Listing

Co-administration of Erythromycin and Leech Salivary Extract Alleviates Osteomyelitis in Rats Induced by Methicillin-Resistant Staphylococcus aureus.

Vet Comp Orthop Traumatol 2020 Apr 30. Epub 2020 Apr 30.

Department of Pathobiology, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran (the Islamic Republic of).

Objective:  Erythromycin (Ery) and leech saliva (LS) can inhibit growth in conditions. This study aimed to evaluate the activities and synergy between Ery and LS on chronic osteomyelitis in male Wistar rat's tibia induced by methicillin-resistant (MRSA).

Materials And Methods:  Four weeks after osteomyelitis induction, rats were divided into four groups including no treatment (control), Ery monotherapy (orally), LS monotherapy, or Ery + LS twice daily for 2 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1703008DOI Listing

Imaging features in patients with SAPHO/CRMO: a pictorial review.

Jpn J Radiol 2020 Apr 30. Epub 2020 Apr 30.

Department of Radiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome and chronic recurrent multifocal osteomyelitis (CRMO) have been described as disorders of chronic osteoarthritic inflammation frequently associated with skin manifestations, and SAPHO and CRMO (SAPHO/CRMO) are rare autoinflammatory disorders of unknown etiology. SAPHO tends to occur in adults and CRMO predominantly occurs in children and adolescents. SAPHO/CRMO can affect any skeletal region (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11604-020-00953-1DOI Listing

Short-Term Outcome and MRI Changes in Three Adult Patients with Sickle Cell Disease and Aseptic Osteonecrosis after Treatment with Hyperbaric Oxygen Therapy: A Preliminary Report.

Case Rep Oncol 2020 Jan-Apr;13(1):365-372. Epub 2020 Apr 2.

Hematology Section/Medical Oncology (NCCCR), Hamad General Hospital Doha, Doha, Qatar.

Background: Musculoskeletal manifestations are common in sickle cell disease (SCD). Vaso-occlusive crisis can manifest acutely as joint and bone pain, osteomyelitis and/or arthritis. It can also lead to chronic bone aches, bone deformities, degenerative arthritis, pathological fractures, and osteoporosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000506330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184821PMC

Microbiological profile of chronic osteomyelitis with special reference to anaerobic osteomyelitis in a tertiary care hospital of coastal Karnataka.

Trop Doct 2020 Apr 28:49475520921283. Epub 2020 Apr 28.

Professor and Head, Department of Microbiology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.

Chronic osteomyelitis is a relapsing, persistent, low-grade inflammation of bone caused by various infectious agents. The present study, conducted over a two-year period, on specimens received from cases of chronic osteomyelitis was, to determine the frequency of isolation of aerobic and anaerobic bacteria and to analyse their antimicrobial susceptibility pattern. Specimens were processed for Gram stain, aerobic and anaerobic culture, and were identified according to standard techniques. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0049475520921283DOI Listing

Micropore Particle Technology Promotes Wound Healing, Whereas Polyhexamethylene Biguanide Causes Tissue Degeneration: A Case Report.

Wounds 2020 Mar;32(3):E6-E10

Willingsford Ltd, Southampton, Hampshire, United Kingdom.

Case Report: A 72-year-old woman with a nontraumatic spinal cord injury developed eschar on her lower right back. An underlying abscess was identified, which upon surgical debridement left a large wound extending down to the hip bone. In addition, the hip suffered from chronic osteomyelitis and was exposed at the bottom of the wound. Read More

View Article

Download full-text PDF

Source

Limb Salvage Rates and Functional Outcomes Using a Longitudinal Slit Arteriotomy End-to-Side Anastomosis for Limb-Threatening Defects in a High-Risk Patient Population.

Plast Reconstr Surg 2020 May;145(5):1302-1312

Washington, D.C.; and Houston, Texas From the Departments of Plastic and Reconstructive Surgery and Vascular Surgery, MedStar Georgetown University Hospital; Georgetown University School of Medicine; and the University of Texas M. D. Anderson Cancer Center.

Background: Limb salvage techniques using free tissue transfer in patients with chronic wounds caused by longstanding osteomyelitis, diabetes, and peripheral vascular disease are technically challenging. The longitudinal slit arteriotomy end-to-side anastomosis is the authors' preferred technique because it is the least invasive arteriotomy and is especially important for diseased recipient arteries. The authors reviewed highly comorbid patients who underwent free tissue transfer with this technique to understand the success rates, overall outcomes, and long-term limb salvage rates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PRS.0000000000006791DOI Listing

Impact of bone events on survival in solitary bone plasmacytoma.

Rep Pract Oncol Radiother 2020 May-Jun;25(3):389-395. Epub 2020 Apr 12.

Department of Radiology and Oncology, Instituto de Radiologia do Hospital das Clínicas, Medical School os Sao Paulo University, Brazil.

Background: Although much studied in multiple myeloma, bone events (BE) can also cause important morbidity in bone plasmacytoma patients. To our knowledge, the effect of BE on overall survival (OS) and progression to multiple myeloma free-survival (MPFS) also has never been studied.

Patients And Methods: Fifty-nine patients treated from 2008 to 2017 were retrospectively assessed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rpor.2020.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171253PMC

Safety and tolerability of more than 6 days of tedizolid treatment.

Antimicrob Agents Chemother 2020 Apr 20. Epub 2020 Apr 20.

Department of Infectious Diseases, Hospital Clinic, University of Barcelona, Barcelona, Spain.

Tedizolid has demonstrated its efficacy and safety in clinical trials, however, data concerning its tolerability in long-term treatments is scarce. The aim of the study was to assess the indications and to describe the long-term safety profile of tedizolid.A multicentric, retrospective study of patients who received tedizolid for more than 6-days was conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00356-20DOI Listing

Foot Salvage with Selective Arterialization of Pedal Venosomes.

Plast Reconstr Surg Glob Open 2020 Feb 20;8(2):e2612. Epub 2020 Feb 20.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University in St. Louis, St. Louis, Mo.

Background: Lower extremity salvage using microvascular flaps can be considered in high-functioning patients, but indications for salvage are often restricted by distal microvascular disease that may threaten the foot as a whole. Selective arterialization of specific pedal venosomes is a novel potential solution to this problem.

Methods: A 48-year-old man with a chronic left plantar forefoot wound, osteomyelitis of the second and third metatarsal heads, and critical limb ischemia was evaluated for foot salvage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/GOX.0000000000002612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159967PMC
February 2020

Diagnosing and treating native spinal and pelvic osteomyelitis in adolescents.

Spine Deform 2020 Apr 18. Epub 2020 Apr 18.

Department of Orthopedic Surgery, Boston Children's Hospital, Hunnewell 2, 300 Longwood Avenue, Boston, MA, 02115, USA.

Study Design: Retrospective case series.

Objectives: To describe how pediatric patients with spinal and pelvic osteomyelitis are diagnosed and treated and assess the diagnostic value of magnetic resonance imaging (MRI), needle aspiration biopsy (NAB), and blood cultures in this population. Spinal and pelvic osteomyelitis de novo are uncommon in children and minimal literature exists on the subject. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s43390-020-00110-8DOI Listing

Subarticular Inflammatory Pseudoabscesses: A Pathologic Study With Clinical Correlation.

Am J Surg Pathol 2020 May;44(5):633-640

Department of Pathology and Laboratory Medicine, Hospital for Special Surgery.

Abnormal accumulation of neutrophils in a subarticular bone usually raises the concern for osteomyelitis or septic arthritis, a disabling and potentially life-threatening medical condition. At the pathology department of a specialized orthopedic institute, we observed a distinct pattern of subarticular inflammation mimicking infection characterized by collections of neutrophils, macrophages, and fibrin in pseudocystic spaces of variable size and extent in the superficial subarticular bone not accompanied by granulation tissue or necrosis. We coined the term "inflammatory pseudoabscess" to describe these accumulations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAS.0000000000001440DOI Listing

Inflammatory manifestations in patients with Shwachman-Diamond syndrome: A novel phenotype.

Am J Med Genet A 2020 Apr 15. Epub 2020 Apr 15.

Dana-Farber and Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.

Shwachman-Diamond syndrome (SDS) is an autosomal recessive multisystem disorder characterized by exocrine pancreatic dysfunction, bone marrow failure, and leukemia predisposition. Approximately 90% of cases are due to biallelic mutations in the Shwachman-Bodian-Diamond (SBDS) gene. Additional phenotypic features variably associated with SDS include skeletal, neurologic, hepatic, cardiac, endocrine, and dental abnormalities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.a.61593DOI Listing

A novel variant in the neutrophil cytosolic factor 2 (NCF2) gene results in severe disseminated BCG infectious disease: A clinical report and literature review.

Mol Genet Genomic Med 2020 Apr 12:e1237. Epub 2020 Apr 12.

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.

Background: Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder (PID) affecting NADPH oxidase activity. The rarest form of the disease is considered to be caused by NCF2 gene bi-allelic variant. Here, we report the clinical and molecular characterization of a patient presenting with early-onset severe disease due to bi-allelic NCF2 variant. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mgg3.1237DOI Listing

Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome with Purely Osteolytic, Not Osteosclerotic, Lesions Mimicking a Malignant Tumor.

Case Rep Rheumatol 2020 28;2020:6316921. Epub 2020 Mar 28.

Department of Orthopedic Surgery, Chiba Cancer Center, 666-2 Nitonacho, Chuo-ku, Chiba 260-8717, Japan.

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare inflammatory disorder with multiple phenotypes. The syndrome has identifiable radiologic characteristics that are the most important when making a diagnosis. X-rays of cases diagnosed with SAPHO syndrome reveal sclerotic lesions or mixed lytic and sclerotic lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/6316921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142334PMC

The effect of calcium sulfate/calcium phosphate composite for the treatment of chronic osteomyelitis compared with calcium sulfate.

Ann Palliat Med 2020 Mar 31. Epub 2020 Mar 31.

Department of Orthopaedics, Second Affiliated Hospital, Air Force Medical University, Xi'an 710038, China.

Background: Treatment of chronic osteomyelitis often requires surgical debridement in combination with bone defect reconstruction and antibiotics administration. We aimed at investigating and evaluating the effect of antibiotic-loaded absorbable calcium sulfate/calcium phosphate (CS/CP) composite as bone substitute in the treatment of chronic osteomyelitis compared with CS.

Methods: A retrospective study of 31 consecutive patients with chronic osteomyelitis from one medical center was conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm.2020.03.23DOI Listing

How ESKD complicates the management of diabetic foot ulcers: The vital role of the dialysis team in prevention, early detection, and support of multidisciplinary treatment to reduce lower extremity amputations.

Semin Dial 2020 Apr 10. Epub 2020 Apr 10.

Division of Nephrology, Tufts Medical Center, Boston, MA, USA.

Diabetic foot ulcers do not heal as well in ESKD as in the absence of kidney failure, and rates of recurrent foot ulcers, as well as lower extremity amputation, are higher. This review of the literature highlights the vital role of the dialysis team in prevention, early detection, and support of treatment of diabetic foot ulcers. Our review has five goals-(a) increase nephrologists' understanding of the high morbidity and mortality associated with chronic foot ulcers and (lower extrimity) LE amputations in ESKD; (b) promote nephrologists' understanding of grading systems for diabetic foot ulcer severity, in order to expedite communication with local diabetic foot experts; (c) promote collaboration between nephrologists and infectious disease specialists regarding the dose, route, and delivery logistics of intravenous antibiotics for infected chronic foot ulcers, in particular in the presence of osteomyelitis and other deep-seated infections; (d) increase the awareness of dialysis nurses, technicians, dietitians, social workers and administrators regarding evidence-based and multidisciplinary approaches to patients' diabetic foot ulcers; (e) encourage the application of published works integrating patient-centered diabetic foot education into the dialysis setting to reduce lower extremity amputations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/sdi.12875DOI Listing

A Case of Chronic Limb-Threatening Ischemia with Heel Ulcers Cured by Revascularization and Partial Calcanectomy.

Ann Vasc Dis 2020 Mar;13(1):86-89

Department of Vascular Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.

Ischemic limbs with infected heel ulcers are often difficult to salvage. We present a case of an 82-year-old woman who had bilateral heel ulcers owing to chronic limb-threatening ischemia. She underwent right femoral-terminal posterior tibial artery bypass surgery, but right calcaneus osteomyelitis occurred and inhibited wound healing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3400/avd.cr.19-00122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140168PMC

Treatment of fracture-related infection of the lower extremity with antibiotic-eluting ceramic bone substitutes: case series of 35 patients and literature review.

Infection 2020 Jun 8;48(3):333-344. Epub 2020 Apr 8.

Department of Trauma Surgery, Klinikum Rechts Der Isar, School of Medicine, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.

Introduction: The current treatment concepts of fracture-related infection (FRI) [Consensus Conference (Anti-Infection Task Force (AITF)) on the definition of acute or chronic osteomyelitis (cOM)] are associated with unsolved challenges and problems, underlining the need for ongoing medical research.

Method: Literature review of treatments for FRI and description of own cases.

Results: We could include eight papers with 394 patients reporting treatments and outcome in FRI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s15010-020-01418-3DOI Listing

Long-term results after internal partial forefoot amputation (resection): a retrospective analysis.

Arch Orthop Trauma Surg 2020 Apr 7. Epub 2020 Apr 7.

Division of Technical Orthopedics, Department of Orthopedic Surgery, Balgrist University Hospital, Forchstrasse 340, 8008, Zurich, Switzerland.

Introduction: Internal partial forefoot amputation (IPFA) is a treatment option for osteomyelitis and refractory and recurrent chronic ulcers of the forefoot. The aim of our study was to assess the healing rate of chronic ulcers, risk of ulcer recurrence at the same area or re-ulceration at a different area and revision rate in patients treated with IPFA.

Materials And Methods: All patients who underwent IPFA of a phalanx and/or metatarsal head and/or sesamoids at our institution because of chronic ulceration of the forefoot and/or osteomyelitis from 2004 to 2014 were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00402-020-03441-3DOI Listing

Bony cystic lesion with associated submandibular lymphadenopathy on a background of breast carcinoma: an unexpected case of cervicofacial actinomycosis.

BMJ Case Rep 2020 Apr 6;13(4). Epub 2020 Apr 6.

Department of Oral and Maxillofacial Surgery, Queen Elizabeth Hospital Birmingham, Edgbaston, UK.

Actinomycosis is an uncommon, chronic suppurative granulomatous infection and needs to be considered as a differential diagnosis. A 56-year-old woman with a background of type 2 diabetes mellitus and breast carcinoma was referred to the Oral and Maxillofacial Surgery 2-week wait clinic, regarding a tender sublingual mass and firm erythematous swelling in the right submandibular and submental region. This was slowly progressive and had not responded to oral co-amoxiclav. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2019-232850DOI Listing

Treatment of chronic Osteomyelitis with vascularized bone flaps in one-stage-procedure.

Handchir Mikrochir Plast Chir 2020 Apr 7;52(2):116-122. Epub 2020 Apr 7.

Azienda Ospedaliero Universitaria Citta della Salute e della Scienza di Torino.

Background: Chronic osteomyelitis is a long-standing infection of the bone. Treatment is often combined, using antibiotics and surgery (with radical debridement and secondary or concomitant reconstruction). One-stage management is an alternative approach, with few reported cases in literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1075-2402DOI Listing

New variant in the IL1RN-gene (DIRA) associated with late-onset, CRMO-like presentation.

Rheumatology (Oxford) 2020 Apr 7. Epub 2020 Apr 7.

Department of Immunology, University of Tuebingen, Tuebingen.

Objective: To report a chronic recurrent multifocal osteomyelitis (CRMO)-like clinical phenotype with multisystem inflammation associated with a novel gene variant in the spectrum of IL-1-mediated diseases.

Methods: A 3-year-old boy presented with recurrent episodes of fever, serositis, pancreatitis and high inflammatory markers with onset at age 13 months. At age 3 years, he started limping. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/keaa119DOI Listing

Outcomes of Tibiocalcaneal Arthrodesis in High-Risk Patients: An Institutional Cohort of 18 Patients.

Indian J Orthop 2020 Feb 4;54(1):14-21. Epub 2020 Feb 4.

1Department of Orthopaedic Surgery, University of Alabama at Birmingham, 1313 13th Street South, Birmingham, AL 35205 USA.

Introduction: Tibiocalcaneal (TC) arthrodesis is commonly performed in patients with severe hindfoot disease. These include severe Charcot deformities, ankle malformations, chronic osteomyelitis (COM), and avascular necrosis (AVN). The talar vascular becomes disrupted to the point that the bone can no longer be salvaged. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s43465-020-00048-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093629PMC
February 2020

Reconstruction Using Free Flaps for Diabetic Heel Defects: Outcomes and Risk Factor Analysis.

J Reconstr Microsurg 2020 Apr 6. Epub 2020 Apr 6.

Department of Plastic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background:  Overall success rate after diabetic foot reconstruction using free flap has been acceptable, but certain parts of the foot like the heel remains more challenging.

Patients And Methods:  This retrospective study reviewed 37 patients reconstructed with free flaps for diabetic foot ulcer on the heel region from 2008 to 2017. Flap outcome in addition to various risk factors were analyzed; arterial status on heel, the American Society of Anesthesiologists (ASA) physical status, smoking, hypertension, hypercholesterolemia, chronic renal failure patient, hemoglobin A1c level, C-reactive protein, and osteomyelitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1709477DOI Listing

Antibiotic cement spacer retention for chronic shoulder infection after minimum 2-year follow-up.

J Shoulder Elbow Surg 2020 Mar 31. Epub 2020 Mar 31.

Kentucky Bone and Joint Surgeons, Lexington, KY, USA.

Hypothesis: The treatment of periprosthetic shoulder infections and proximal humerus osteomyelitis is challenging. The outcomes of antibiotic cement spacer retention are poorly defined in the literature. The purpose of this study was to review long-term functional and patient-reported outcomes data of patients with retained antibiotic cement spacers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jse.2020.01.065DOI Listing

Acute Delirium Induced by Ciprofloxacin in a Patient With Chronic Kidney Disease: A Case Report.

JBJS Case Connect 2020 Apr-Jun;10(2):e0603

Department of Orthopaedic Surgery, University of California, San Francisco, California.

Case: Ciprofloxacin is increasingly used as oral suppressive therapy for musculoskeletal infections. Delirium and acute hypoglycemia are little-known, severe potential adverse drug reactions. We report here on a patient who experienced both complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2106/JBJS.CC.19.00603DOI Listing