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Malays Orthop J 2019 Mar;13(1):25-29

Department of Surgery, International Islamic University of Malaysia, Kuantan, Malaysia.

Large wounds in the leg require combination of local flaps or free flap for wound coverage. Gastrocnemius musculocutaneous flap (GMCF) allows a large wound to be covered by a single local flap. However, the conventional GMCF is often associated with donor site morbidity where the exposed soleus raphe causes poor uptake of the skin graft. Read More

Foot Ankle Surg 2019 Apr 2. Epub 2019 Apr 2.

Dept. of Orthopaedics, Sri Sathya Sai Institute of Higher Medical Sciences - Prasanthigram, Puttaparthi, Andhra Pradesh, 515134 India. Electronic address:

Background: Diagnosis and classification of chronic osteomyelitis is not based on any objective criteria. None of the available methods for this is completely reliable. Tienmann et al. Read More

Ther Clin Risk Manag 2019 27;15:525-530. Epub 2019 Mar 27.

Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran,

Fosfomycin (CHOP) is a phosphonic acid derivative representing an epoxide class of antibiotics. The drug is a re-emerging bactericidal antibiotic with a wide range of actions against several Gram-positive and Gram-negative bacteria. Among the existing antibacterial agents, fosfomycin has the lowest molecular weight (138 Da), which is not structurally associated with other classes of antibiotics. Read More

J Rheumatol 2019 Apr 15. Epub 2019 Apr 15.

From the Department of Rheumatology, Aarhus University Hospital, Denmark; Department of Radiology, Aarhus University Hospital, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital, Denmark. Aarhus University has financially supported this work. Address correspondence to Caroline Marie Andreasen, MD, Department of Rheumatology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark. E-mail:

Objective: Chronic non-bacterial osteomyelitis (CNO) is a sterile inflammatory bone disorder with an unpredictable course of disease. The aim of the present study was to assess clinical and radiological disease activity in children with CNO including response to early-onset pamidronate treatment in CNO.

Methods: We conducted a single center retrospective study of children fulfilling the Bristol Criteria for CNO. Read More

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):258-270

Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy, Istituto di Clinica delle Malattie Infettive, Università Cattolica S. Cuore, Rome, Italy.

Chronic osteomyelitis is a difficult to treat infection of the bone, which requires a combined medical and surgical approach and often persists intermittently for years, with relapses and failures. The optimal type, route of administration, and duration of antibiotic treatment remain controversial, and the emergence of multi-drug resistant organisms poses major therapeutic challenges. Identification of the causative agent and subsequent targeted antibiotic treatment has a major impact on patients' outcome. Read More

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):201-209

Infectious Diseases Unit, Department of Medical and Surgical Sciences, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

The term spondylodiscitis describes the infection of both the intervertebral disc space and the adjacent vertebrae. Pyogenic Vertebral Osteomyelitis (PVO) is more common in older patients (mean age 59-69 years) with a male preponderance (52-69%). Recent studies reported an alarming increase of incidence over the last 20 years, due to the increase of diagnostic sensibility, the increase of the average lifetime and to the consequent association of chronic disabling pathologies, of immunosuppression, of surgical or invasive procedure. Read More

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):26-37

Diabetes Care Unit, Endocrinology, University Hospital "A. Gemelli", Catholic University of the Sacred Heart, Rome, Italy.

Diabetic foot ulcers (DFUs), a micro-vascular complication, are associated with a substantial increase in morbidity and mortality. DFUs are a complicated mixture of neuropathy, peripheral arterial diseases, foot deformities, and infections. Foot infections are frequent and potentially devastating complications. Read More

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):199-205

Department of Pathology, Regional Cancer Centre, Thiruvananthpuram, Kerala, India.

Small round cell lesions of the bone encompass a heterogeneous group of tumors and tumor-like lesions, including Ewing sarcoma, small cell osteosarcoma, mesenchymal chondrosarcoma, neuroblastoma, non-Hodgkin's lymphoma (NHL), "Ewing-like" undifferentiated round cell sarcomas, metastasizing small cell carcinoma, along with plasma cell dyscrasia and Langerhan's cell histiocytosis. At the same time, there are tumor mimics, for example, chronic osteomyelitis, which has overlapping radiologic features with Ewing sarcoma and a primary intraosseous NHL. An exact diagnosis necessitates integration of clinical, radiologic, pathologic, and ancillary test results, including immunohistochemical and molecular results. Read More

Am J Case Rep 2019 Apr 9;20:482-488. Epub 2019 Apr 9.

Department of Hematology and Bone Marrow Transplantation, Hospital de Santa Maria, CHLN - EPE, Lisboa, Portugal.

BACKGROUND Osteomyelitis (OM) due to carbapenemase-producing Klebsiella pneumoniae (CPKp) is a very rare but severe condition, particularly among patients with hematologic malignancies and stem cell transplant recipients, who are especially at risk of developing nosocomial infections caused by this bacterium. CASE REPORT We describe 2 cases of acute and chronic OM by CPKp in adults with hematologic disorders. Patient 1, with acute lymphoblastic leukemia, developed bacteremia due to multidrug CPKp after induction chemotherapy. Read More

Int J Surg Case Rep 2019 Mar 26. Epub 2019 Mar 26.

Hospital Angeles del Pedregal, Mexico; Hospital Infantil de México Federico Gómez, Mexico.

Introduction: Necrotizing fasciitis (NF) is a severe infectious condition associated with significant morbidity and mortality and characteristically has a higher incidence in adults; pediatric cases are very rare. In this case report we describe, the clinical presentation, management and outcome of a patient with necrotizing fasciitis of the neck and head complicated with chronic osteomyelitis.

Presentation Of The Case: An 18 month-old, latin, male, diagnosed with rickets and Crouzon syndrome, twenty-four hours post- craniofacial remodeling surgery presented tissue edema, indurated skin and violaceous and well delimited lesions in the neck and head. Read More

Biomed Res Int 2019 4;2019:7483537. Epub 2019 Mar 4.

Department of Orthopaedics & Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Background: Previous studies had indicated that interleukin-1 beta (IL-1) gene single nucleotide polymorphisms (SNPs) associate with different inflammatory diseases. However, potential links between these polymorphisms and susceptibility to extremity chronic osteomyelitis (COM) remain unclear. This study aimed to investigate relationships between IL-1 gene polymorphisms (rs16944, rs1143627, rs1143634, and rs2853550) and risks of developing extremity COM in Chinese Han population. Read More

World Allergy Organ J 2019 14;12(3):100019. Epub 2019 Mar 14.

Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Germany.

Background: Systemic autoinflammatory diseases (SAIDs) are rare debilitating disorders of which there is limited awareness and a significant delay in diagnosis. There is no uniform approach in the diagnosis and treatment of these disorders and the real life state of SAID patient care is poorly characterized. The aim of this study was to obtain data on the epidemiology, state of care and the perception of physicians who are involved in the care of SAID patients. Read More

Wounds 2019 Apr;31(4 Suppl):S19-S27

Ali Anaim, DPM PC, Philadelphia, PA; Temple University Hospital, Philadelphia, PA; Episcopal Hospital, Philadelphia, PA; Nazareth Hospital, Philadelphia, PA; Phoenixville Hospital, Phoenixville, PA; Pennsylvania Surgery and Laser Center, Philadelphia, PA.

Introduction: Over time, acute and chronic, nonhealing wounds impose heavy financial and quality-of-life burdens on patients. The introduction of new therapies for wounds is essential in benefiting the patient, and in this report, the clinical experience of various wound care providers treating wounds with dehydrated amnion/chorion membrane (dACM) is presented.

Objective: This retrospective clinical experience evaluated the effects of dACM in the treatment of 50 acute and chronic wounds of various etiologies. Read More

Int Wound J 2019 Mar 27. Epub 2019 Mar 27.

Department of Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland.

Autologous bone grafting is the gold standard in patients with bone defects but is associated with significant pain and donor site morbidity. Autologous lipotransfer (fat grafting or lipofilling) has become very popular in the therapy of chronic wounds. Mesenchymal stem cells from adipose tissue are known for their regenerative, reparative, and immunomodulatory effects. Read More

EJNMMI Res 2019 Mar 22;9(1):29. Epub 2019 Mar 22.

Department of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, Denmark.

Purpose: To examine parameters affecting the detection of osteomyelitis (OM) by [F]FDG PET/CT and to reduce tracer activity in a pig model.

Background: [F]FDG PET/CT is recommended for the diagnosis of OM in the axial skeleton of adults. In children, OM has a tendency to become chronic or recurrent, especially in low-income countries. Read More

BMJ Case Rep 2019 Mar 20;12(3). Epub 2019 Mar 20.

Sports Medicine, Rothman Institute, Philadelphia, Pennsylvania, USA.

Osteomyelitis is an inflammatory process of the bone caused by an infection. The key to successful management is early recognition and treatment, as complications can arise if interventions are not done in a timely manner. Subacute or chronic osteomyelitis is associated with avascular necrosis of bone requiring surgical debridement and antibiotic therapy. Read More

BMJ Case Rep 2019 Mar 20;12(3). Epub 2019 Mar 20.

Department of Oral and Maxillofacial Surgery, The Queen Elizabeth Hospital, Birmingham, UK.

Malignant infantile osteopetrosis (MIOP), an autosomal-recessive disorder, is extremely rare, presenting early in life with extreme sclerosis of the skeleton and reduced activity of osteoclasts. It was first described by Albers Schonberg in 1904. Disease manifestations include compensatory extramedullary haematopoiesis at sites such as the liver and spleen, hepatosplenomegaly, anaemia and thrombocytopaenia. Read More

Br J Oral Maxillofac Surg 2019 Mar 18. Epub 2019 Mar 18.

Department of Oral and Maxillofacial Surgery, Daejeon Dental Hospital, Wonkwang University College of Dentistry, 77 Dunsan-ro, Daejeon, 302-830, Republic of Korea; Wonkwang Bone Regeneration Research Institute, Daejeon Dental Hospital, Wonkwang University College of Dentistry, Daejeon, Republic of Korea. Electronic address:

Cemento-osseous dysplasia is a well-known condition in which healthy bone becomes sclerotic. Hypovascularity of the lesion (caused by cementum-like deposits) increases the risk of secondary infection and osteomyelitis, which can also be induced by the placement of implants. Read More

Open Access Maced J Med Sci 2019 Feb 25;7(4):610-613. Epub 2019 Feb 25.

Department of Neurology, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia.

Background: Access to modern medicine is still limited in some rural areas in Indonesia. This is mostly due to lack of people's knowledge and concern for their health, especially in orthopaedic cases. Osteomyelitis is generally described as infection and inflammation of the bone, which results in local bone destruction, necrosis, and apposition of new bone. Read More

J Biomed Nanotechnol 2019 May;15(5):1097-1105

An effective local drug delivery system remains an urgently needed product for the treatment of chronic osteomyelitis in the clinic. In this study, we developed an antibacterial functionalization bone graft by immobilizing levofloxacin hydrochloride-loaded mesoporous silica microspheres (LFH @ MSNs) on the surface of a nanohydroxyapatite/polyurethane (-HA/PU) bioactive composite scaffold. Through pretreatment of the -HA/PU scaffold by chitosan solution and subsequent crosslinking by vanillin, LFH @ MSNs were uniformly and stably immobilized on the scaffold surface. Read More

Foot (Edinb) 2019 Jan 11;39:22-27. Epub 2019 Jan 11.

Trauma and Orthopaedics Department, Wythenshawe Hospital, Manchester University Foundation Trust, United Kingdom. Electronic address:

Background: Diabetic foot ulcers are associated with a high morbidity and are common cause of non-traumatic lower limb amputations. The effect of debridement and the use of an adjuvant local antibiotic carrier in the treatment of diabetic foot ulcers with osteomyelitis was evaluated.

Methods: A retrospective review of patients with diabetic foot ulceration and osteomyelitis treated by debridement with adjuvant local antibiotic was performed. Read More

Asian Spine J 2019 Mar 15. Epub 2019 Mar 15.

Department of Orthopaedic Surgery, Waikato Hospital, Hamilton, New Zealand.

Study Design: Retrospective cohort study.

Purpose: To describe our experience in the management and outcomes of vertebral column osteomyelitis (VCO), particularly focusing on the risk factors of early and late mortality.

Overview Of Literature: Previous reports suggest a global increase in spinal column infections highlighting significant morbidity and mortality. Read More

HSS J 2019 Feb 8;15(1):84-92. Epub 2019 Jan 8.

2UHealth Sports Medicine Institute, University of Miami Miller School of Medicine, Coral Gables, FL USA.

Background: Given the high prevalence of musculoskeletal conditions in the USA, it is important for orthopedic surgeons to promptly identify patients who may be at risk for opioid misuse.

Questions/purposes: The aim of this literature review was to elucidate various musculoskeletal pathologies and complications, as seen on imaging, that may indicate opioid misuse or opioid use disorder.

Methods: A literature search was conducted using the PubMed, Scopus, and Cochrane Library databases for articles related to imaging findings associated with chronic opioid use or misuse in orthopedic patients. Read More

Clin Med Insights Case Rep 2019 5;12:1179547619835182. Epub 2019 Mar 5.

Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Introduction: Cholesteatoma of the paranasal sinuses is uncommon. Its clinical characteristics are an expanding growth of the affected paranasal sinuses consisting of keratinizing squamous epithelium with bony wall destruction. Among involved paranasal sinuses, sphenoid sinus cholesteatoma is the least common. Read More

Ann R Coll Surg Engl 2019 Mar 11:1-5. Epub 2019 Mar 11.

Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of Stomatology, Shandong University , Jinan, Shandong Province , China.

Chronic osteomyelitis with proliferative periostitis is a rare form of osteomyelitis that is characterised by new bone formation with periosteal reaction. It is also traditionally known as Garre's osteomyelitis. The common sources of infection of the jaw include dental caries associated with periapical periodontitis, periodontitis, fractures and nonodontogenic infections. Read More

Toxicol Sci 2019 Mar 8. Epub 2019 Mar 8.

Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food & Drug Administration, 10903 New Hampshire Ave., Silver Spring, Maryland.

Checkpoint inhibitors represent a new class of therapeutics in the treatment of cancer that have demonstrated remarkable clinical effectiveness. However, some patients have experienced serious immune-mediated adverse effects including pneumonitis, hepatitis, colitis, nephritis, dermatitis, encephalitis, and adrenal or pituitary insufficiency. These adverse events were not predicted by nonclinical studies. Read More

Acta Chir Orthop Traumatol Cech 2019 ;86(1):51-57

Ortopedická klinika Fakultní nemocnice a Lékařské fakulty Univerzity Karlovy, Hradec Králové.

PURPOSE OF THE STUDY The aim of this study was to evaluate the mid-term outcomes of the surgical reconstruction of Charcot Foot Neuroarthropathy in diabetic patients with failed conservative treatment and indicated for a below-knee amputation. MATERIAL AND METHODS In the period from 2010 to 2015 the surgical reconstruction of inactive, chronic Charcot Foot Neuroarthropathy classified as type II and III by Sanders and Frykbeg was performed in 16 patients with failed conservative treatment. All these patients were by the diabetes centres initially indicated for a below-knee amputation. Read More

Case Rep Pediatr 2019 31;2019:5163213. Epub 2019 Jan 31.

Pediatric Gastroenterology Division, Children's Hospital, King Fahad Medical City, Riyadh, Saudi Arabia.

The relationship of inflammatory bowel disease (IBD) and chronic recurrent multifocal osteomyelitis (CRMO) is understood as extraintestinal rheumatic manifestations. CRMO is a chronic, relapsing, inflammatory, noninfectious disorder of the skeletal system of unknown origin. The disease course is not always recurrent. Read More

J Child Orthop 2019 Feb;13(1):33-39

Trauma and Orthopaedic Department, St George's Hospital, London, UK.

Purpose: The paediatric sickle cell disease (SCD) osteomyelitis (OM) incidence is 0.3% to 12%. Differentiating vaso-occlusive crises (VOC) from OM is a diagnostic challenge, with limited evidence guiding management. Read More

J Shoulder Elbow Surg 2019 Feb 27. Epub 2019 Feb 27.

Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

Background: It is usually difficult to diagnose clavicular osteomyelitis (OM), and treatment is delayed because of its rarity. This study aimed to summarize clinical characteristics and treatment of this disease.

Methods: We searched the PubMed and Embase databases to identify English studies that reported on clavicular OM from January 1980 through December 2016. Read More

Med Clin (Barc) 2019 Feb 26. Epub 2019 Feb 26.

Departamento de Dermatología, Hospital Universitario Virgen Macarena, Sevilla, España.

Toxins (Basel) 2019 Mar 1;11(3). Epub 2019 Mar 1.

Institute of Medical Microbiology, Jena University Hospital, 07747 Jena, Germany.

colonizes epithelial surfaces, but it can also cause severe infections. The aim of this work was to investigate whether bacterial virulence correlates with defined types of tissue infections. For this, we collected 10⁻12 clinical strains each from nasal colonization, and from patients with endoprosthesis infection, hematogenous osteomyelitis, and sepsis. Read More

BMC Infect Dis 2019 Feb 28;19(1):203. Epub 2019 Feb 28.

Department of infectious disease, Wuming Hospital of Guangxi Medical University, Nanning, China.

Background: Nontuberculous mycobacterial (NTM) disease is commonly an opportunistic infection frequently found in immunocompromised individuals, but sometimes can also be found in the immunocompetent hosts, especially in East Asians. The NTM separation rate in China is increasing, which reminds us to focus on NTM infections in immunocompromised populations.

Case Presentation: A 43-year-old woman with a recurrent fever for more than 8-month and a right forehead surgical wounds unhealed for more than 6-month was admitted to our hospital on February 22, 2018. Read More

Mol Med Rep 2019 Apr 20;19(4):3291-3297. Epub 2019 Feb 20.

Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Medical College, Zhejiang University, Hangzhou, Zhejiang 310006, P.R. China.

Osteomyelitis, which is characterized by progressive inflammatory bone destruction and resorption, is a difficult‑to‑treat infection. Staphylococcus aureus (S. aureus) is one of the major causes of this disease. Read More

Pharmaceutics 2019 Feb 22;11(2). Epub 2019 Feb 22.

Department of Biomedical Engineering, University of Rochester, Rochester, NY 14642, USA.

Osteomyelitis is a chronic bone infection that is often treated with adjuvant antibiotic-impregnated poly(methyl methacrylate) (PMMA) cement spacers in multi-staged revisions. However, failure rates remain substantial due to recurrence of infection, which is attributed to the poor performance of the PMMA cement as a drug release device. Hence, the objective of this study was to design and evaluate a bioresorbable calcium phosphate scaffold (CaPS) for sustained antimicrobial drug release and investigate its efficacy in a murine model of femoral implant-associated osteomyelitis. Read More

Ir J Med Sci 2019 Feb 25. Epub 2019 Feb 25.

Clinical Innovation Unit, Rotunda Hospital, Dublin 1, Ireland.

Background: Staphylococcus aureus bacteraemia (SAB) in NICU patients can cause significant morbidity and mortality.

Aims: To review early and late neonatal SAB with regard to risk factors, treatment, acute complications and long-term outcomes.

Methods: A retrospective study of laboratory confirmed SAB over a 16-year period (November 2001-January 2017) in a tertiary neonatal unit in Ireland. Read More

Am J Case Rep 2019 Feb 25;20:248-251. Epub 2019 Feb 25.

Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

BACKGROUND Medications are one of the most common causes of acute kidney injury (AKI). Elderly patients with diabetes mellitus and chronic kidney disease seem to be at particularly high risk for development of medication-induced AKI. Among antibiotics, the most commonly implicated agents are aminoglycosides, cephalosporins, trimethoprim-sulfamethoxazole, acyclovir, and amphotericin. Read More

Int J Paleopathol 2019 Feb 20. Epub 2019 Feb 20.

1781 Skyline Drive, Santa Ana, CA 92705, United States. Electronic address:

Background: CT scanning was utilized to investigate an intact mummy bundle within the bioarchaeology of care framework. The project sought to ascertain whether a 'virtual' analysis was feasible, thereby avoiding physical disturbance to bundle structure and contents.

Methods: The bundle selected for this study contained an adult male (FA 54), Ichma culture, Peru, displaying evidence for two pathologies: chronic osteomyelitis of the right tibia, and cranial trauma. Read More

J R Army Med Corps 2019 Feb 20. Epub 2019 Feb 20.

Department of Traumatology and Orthopaedics, Septic and Reconstructive Surgery, Bundeswehrkrankenhaus Berlin, Berlin, Germany.

Aim: Combat-related extremity injuries are regularly associated with long-term complications such as chronic infection, especially osteomyelitis. Clinical examination and laboratory parameters do not usually allow reliable diagnosis. In contrast, imaging techniques enable constructive assertions to be made about the location and extent of an infection of the peripheral musculoskeletal system. Read More

Foot Ankle Surg 2019 Feb 5. Epub 2019 Feb 5.

The Department of Orthopaedic Surgery and Rehabilitation, Loyola University Health System, 2160 South First Avenue, Maywood, IL 60153, United States. Electronic address:

Background: Unstable ankle fractures in diabetics with peripheral neuropathy have an increased risk of postoperative complications, often leading to amputation. Primary ankle arthrodesis has been suggested as an alternative when acceptable reduction and mechanical stabilization cannot be obtained.

Methods: Over a fourteen year period, thirteen diabetic patients with peripheral neuropathy underwent an attempt at primary ankle arthrodesis following the early post-fracture development of acute neuropathic (Charcot) deformity of the ankle after sustaining a low energy unstable ankle fracture. Read More

G Chir 2019 Jan-Feb;40(1):49-53

Chronic osteomyelitis represents a challenging to treat clinical entity. A case of a whole femur chronic osteomyelitis, definitely treated with total femur resection and a positioning of a modular megaprosthesis in 2 stages is presented. An 81-year-old female, with hip hemiarthroplasty and internal fixation plate of the distal femur presented with signs and symptoms of femur osteomyelitis. Read More

J Neurosurg Spine 2019 Feb 15:1-9. Epub 2019 Feb 15.

1Department of Neurological Surgery, University of Miami, Miami, Florida; and.

OBJECTIVEDiscitis and osteomyelitis are seen in end-stage renal disease (ESRD) patients due to repeated vascular access for hemodialysis and urinary tract infections leading to recurrent bacteremia. Discitis and osteomyelitis are underdiagnosed due to the nonspecific initial presentation of back pain. In this article, we review the literature for better understanding of the problem and the importance of early diagnosis by primary care physicians and nephrologists. Read More

Lett Appl Microbiol 2019 Apr 13;68(4):294-302. Epub 2019 Mar 13.

Department of Applied Sciences, University of the West of England, Bristol, UK.

Chronic osteomyelitis is difficult to treat, with biofilm growth and the diffusion barrier to antibiotics presented by bone contributory factors. The aim of this study was to develop and evaluate an in vitro model of osteomyelitis. A bioluminescent strain of Staphylococcus aureus was grown in bone blocks made from bovine femur. Read More

J Orthop Surg Res 2019 Feb 12;14(1):47. Epub 2019 Feb 12.

Orthopaedic Department, Minhang Branch, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.

Background: We described the use of the technique of L-shaped corticotomy with bone flap sliding to treat chronic osteomyelitis of the tibia in eight patients and presented the preliminary results.

Methods: L-shaped corticotomy with bone flap sliding was performed in eight patients between 2007 and 2014. All patients had chronic tibial osteomyelitis involving the anterior tibial cortex with intact and healthy posterior cortex. Read More

Clin Infect Dis 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX.

Background: Staphylococcus aureus is the most common cause of acute hematogenous osteoarticular infections (AHOAIs) in children. The risk factors for the development of orthopedic complications (OC) after AHOAI are poorly understood. We sought to describe clinical and microbiologic variables present on the index admission which may predict OC in S. Read More

Med Mycol Case Rep 2019 Jun 14;24:1-4. Epub 2019 Jan 14.

Department of Microbiology, All India Institute of Medical Sciences, Jodhpur 2, Basni, Jodhpur 342005, India.

induced osteomyelitis is infrequent. There is scarcity of literature on this entity in maxillofacial region and thus there is possibility to mismanage such cases. We are presenting a case of chronic maxillofacial osteomyelitis causing palatal and septal perforation with saddle nose deformity in a young lady with commencement and progression of disease process over two pregnancies. Read More

J Endod 2019 Feb;45(2):181-188

Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts; Department of Endodontics, Boston University Goldman School of Dental Medicine, Boston, Massachusetts.

Introduction: In general, mice develop chronic and nonhealing periapical lesions after endodontic infection. Surprisingly, we recently found that toll-like receptor 2 (TLR2)/interleukin 10 (IL-10) double-knockout (dKO) mice exhibited acute but resolving osteomyelitislike inflammation. In this study, we examined the kinetics of endodontic infection-induced inflammation in TLR2/IL-10 dKO mice and explored a potential mechanism of periapical wound healing mediated by the hypoxia-inducible factor 1 alpha (HIF-1α) subunit and arginase 1. Read More

J Foot Ankle Surg 2019 Jan 23. Epub 2019 Jan 23.

Attending Physician, Geisinger Health System, Danville, PA.

Pathologic fractures of the calcaneus secondary to osteomyelitis (OM) have rarely been reported in the literature. This case series describes 5 patients who were treated in our institution for chronic OM of the calcaneus and subsequently suffered a fracture of the involved calcaneus in the absence of trauma. All 5 patients had a history of insulin-dependent diabetes mellitus and were treated with a range of surgical treatments including open reduction and internal fixation, external fixation, and excision of the fracture fragment. Read More

Drug Discov Ther 2018 ;12(6):374-378

Department of Medicine, All India Institute of Medical Sciences.

Mucormycosis is an uncommon aggressive fungal infection usually seen in immunocompromised hosts or patients with burns and trauma. The common presentations include rhino-orbital-cerebral and pulmonary involvement. Osteoarticular involvement is a rare presentation of this disease. Read More