102 results match your criteria Osteomyelitis Acute Pyogenic

Differential effects of anti-RANKL monoclonal antibody and zoledronic acid on necrotic bone in a murine model of Staphylococcus aureus-induced osteomyelitis.

J Orthop Res 2021 May 15. Epub 2021 May 15.

Department of Orthopaedic Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Osteomyelitis is characterized by progressive inflammatory bone destruction accompanied by severe pain and disability. However, with the exception of antibiotic therapies, there is no established therapy to protect the bone from infectious osteolysis. The anti-receptor activator of nuclear factor-kB ligand (RANKL) monoclonal antibody (anti-RANKL Ab) is a potential drug based on its proven effectiveness in preventing joint bone erosion in rheumatoid arthritis; however, the efficacy and adverse effects of anti-RANKL Ab in osteomyelitis remain to be investigated. Read More

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[Infections of the spine : Pyogenic spondylodiscitis and implant-associated vertebral osteomyelitis].

Unfallchirurg 2021 Jun 10;124(6):489-504. Epub 2021 May 10.

Klinik und Poliklinik für Unfallchirurgie, Universitätsklinikum Regensburg (UKR), Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Deutschland.

Pyogenic (unspecific) spondylodiscitis and implant-associated vertebral osteomyelitis (IAVO) are important diseases with the risk of neurological and septic complications. An early diagnosis is essential in which magnetic resonance imaging (MRI), histopathology and microbiological identification of the pathogen play key roles. The goals of conservative treatment in uncomplicated spondylodiscitis are antibiotic infection control and pain management. Read More

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[Acute haematogenous osteomyelitis of the pelvis with multifocal pyogenic abscesses in an adult].

Khirurgiia (Mosk) 2021 (2):84-87

Sechenov First Moscow State Medical University, Moscow, Russia.

Acute hematogenous osteomyelitis (AHO) in adults is a rare disease complicating timely diagnosis. Even greater difficulties are observed in case of pelvic bone lesion. The authors report AHO of the pelvis an adult. Read More

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February 2021


Acta Clin Croat 2020 Jun;59(2):368-372

1University Hospital of Foča, Department of Radiology, University of East Sarajevo, Foča, Republika Srpska, Bosnia and Herzegovina; 2Srebrnjak Children's Hospital, Zagreb, Croatia; 3Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

Acute osteomyelitis is pyogenic infection of the bone and bone marrow. We report a case of successful diagnosis and treatment in a 12-year-old boy with right shoulder joint osteoarthritis. On admission, he was febrile (39. Read More

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Unusual manifestation of Koch's disease: Gradenigo-Lannois syndrome.

BMJ Case Rep 2020 Nov 2;13(11). Epub 2020 Nov 2.

Otorhinolaryngology & Head Neck Surgery, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Gradenigo-Lannois syndrome or petrous apicitis is an uncommon but a morbid complication of otitis media. Traditionally treated by surgery, recent advances in imaging and antibiotics have favoured a more conservative approach. Although pyogenic organisms are the leading aetiological agent, petrous apicitis due to Koch's bacilli is not rare. Read More

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November 2020

Comparison anterior minimally invasive oblique retroperitoneal approach and posterior transpedicular approach for debridement fusion in patients with lumbar vertebral osteomyelitis: A randomized controlled trial protocol.

Medicine (Baltimore) 2020 Oct;99(44):e22990

Department of Orthopedics.

Background: Pyogenic osteomyelitis of the spine usually occurs in patients over 55 years old with acute osteomyelitis. Surgical treatment and fixation can relieve pain, enhance spinal balance and nerve function, so that patients can walk as soon as possible. Different outcomes of surgical methods include anterior minimally invasive oblique retroperitoneal approach (ORA) and posterior transpedicular approach (PTA). Read More

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October 2020

Methicillin-Resistant (MRSA): One Health Perspective Approach to the Bacterium Epidemiology, Virulence Factors, Antibiotic-Resistance, and Zoonotic Impact.

Infect Drug Resist 2020 22;13:3255-3265. Epub 2020 Sep 22.

Fish Diseases and Management, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.

Methicillin-resistant (MRSA) is a major human pathogen and a historically emergent zoonotic pathogen with public health and veterinary importance. In humans, MRSA commonly causes severe infectious diseases, including food poisoning, pyogenic endocarditis, suppurative pneumonia, otitis media, osteomyelitis, and pyogenic infections of the skin, soft tissues. In the horse, MRSA could cause a localized purulent infection and botryomycosis; in cattle and ewe, localized pyogenic infection and severe acute mastitis with marked toxemia; in sheep, abscess disease resembles caseous lymphadenitis caused by anaerobic strains; in dogs and cats, pustular dermatitis and food poisoning; in pig, exudative epidermatitis "greasy pig disease; in birds, MRSA causes bumble-foot. Read More

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September 2020

A Case of Brodie's Abscess With Tibial Erosion and Extravasation Into Surrounding Soft Tissue.

Cureus 2020 Jun 13;12(6):e8592. Epub 2020 Jun 13.

Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, USA.

Atraumatic limb pain and limp is a common pediatric presentation in the emergency department in the United States. In a majority of cases, these presentations are benign. However, in cases where pediatric patients are repeatedly presenting for atraumatic limb pain, further investigation is required. Read More

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Disseminated Following Open-Heart Surgery, the Heater-Cooler Unit Worldwide Outbreak: Case Report and Minireview.

Front Med (Lausanne) 2020 16;7:243. Epub 2020 Jun 16.

Université de Paris, IAME, INSERM, UMR1137, UFR de Médecine, Paris, France.

Invasive cardiovascular infections by associated with open-heart surgery have been reported worldwide since 2013. Here, we report a case of a 61 year old man, without any other particular medical background, who underwent cardiac surgery for replacing part of the ascending aorta by a bio-prosthetic graft. Eighteen months later, the patient was painful at the lower back with fever. Read More

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Infected Schmorl's node: a case report.

BMC Musculoskelet Disord 2020 May 2;21(1):280. Epub 2020 May 2.

Department of Neurosurgery, Nanoori Hospital Gangnam, 731, Eonju-ro, Gangnam-gu, Seoul, 06048, Republic of Korea.

Background: Schmorls node (SN) are mostly asymptomatic and incidental findings on MRI. However, sometimes they present like acute onset low back pain or acute exacerbation of chronic back pain after minor trauma.

Case Presentation: We present rare case of symptomatic infected SN in 67 years female patient presented with complains of low back pain radiating to right buttock. Read More

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Autoinflammatory diseases in childhood, part 1: monogenic syndromes.

Pediatr Radiol 2020 03 17;50(3):415-430. Epub 2020 Feb 17.

Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.

Autoinflammatory diseases constitute a family of disorders defined by aberrant stimulation of inflammatory pathways without involving antigen-directed autoimmunity. They may be divided into monogenic and polygenic types. Monogenic autoinflammatory syndromes are those with identified genetic mutations, such as familial Mediterranean fever, tumor necrosis factor receptor-associated periodic fever syndrome (TRAPS), mevalonate kinase deficiency or hyperimmunoglobulin D syndrome, cryopyrin-associated periodic fever syndromes (CAPS), pyogenic arthritis pyoderma gangrenosum and acne (PAPA) syndrome, interleukin-10 and interleukin-10 receptor deficiencies, adenosine deaminase 2 deficiency and pediatric sarcoidosis. Read More

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High risk clinical characteristics for pyogenic spinal infection in acute neck or back pain: Prospective cohort study.

Am J Emerg Med 2020 03 17;38(3):491-496. Epub 2019 May 17.

Greater San Antonio Emergency Physicians, Methodist Hospital System, San Antonio, TX, United States of America.

Objective: To identify clinical characteristics associated with pyogenic spinal infection among adults presenting to a community emergency department (ED) with neck or back pain. A secondary objective was to describe the frequency of these characteristics among patients with spinal epidural abscess (SEA).

Methods: We conducted a prospective cohort study in a community ED enrolling adults with neck or back pain in whom the ED provider had clinical concern for pyogenic spinal infection. Read More

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Surgery is safe and effective when indicated in the acute phase of hematogenous pyogenic vertebral osteomyelitis.

Infect Dis (Lond) 2019 04 7;51(4):268-276. Epub 2019 Feb 7.

a Service de Médecine Interne, Hôpital Beaujon, Assistance Publique Hôpitaux de Paris , Clichy , France.

Background: The overall benefit of surgical management in the acute phase of hematogenous pyogenic vertebral osteomyelitis remains difficult to evaluate because of the balance between potential functional benefit versus complications of surgery.

Methods: Between 2000 and 2013, in a tertiary care hospital, we analyzed a cohort of patients with hematogenous pyogenic vertebral osteomyelitis treated surgically and compared them to those treated medically. Neurologic deficit (using the ASIA impairment scale) and pain (using the analgesic level required) 4 months later, recurrences and infection-related deaths 12 months later were evaluated. Read More

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In vivo efficacy of tobramycin-loaded synthetic calcium phosphate beads in a rabbit model of staphylococcal osteomyelitis.

Ann Clin Microbiol Antimicrob 2018 Dec 28;17(1):46. Epub 2018 Dec 28.

Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor Darul Ehsan, Malaysia.

Background: Osteomyelitis is an acute or chronic inflammatory process of the bone following infection with pyogenic organisms like Staphylococcus aureus. Tobramycin (TOB) is a promising aminoglycoside antibiotic used to treat various bacterial infections, including S. aureus. Read More

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December 2018

Childhood Pyogenic Osteomyelitis in Abakaliki, South East Nigeria.

Niger J Surg 2018 Jan-Jun;24(1):27-33

Department of Surgery, Ebonyi State University/Federal Teaching Hospital, Abakaliki, Nigeria.

Background: Pyogenic osteomyelitis is an important child health problem in developing countries. It is a one-disease state with a spectrum of pathological features and clinical forms ranging from acute to chronic presentation. Its pattern of presentation varies from and within subregions. Read More

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Obturator Internus Abscess with Ipsilateral Septic Hip Arthritis.

J Coll Physicians Surg Pak 2016 Nov;26(11):144-145

Department of Orthopaedic Surgery, Busan Paik Hospital College of Medicine, Inje University, Busan, Korea.

Obturator internus muscle (OIM) abscess is an uncommon condition often mistaken for bacterial infection of the hip joint. If the OIM abscess is accompanied by a septic hip, it becomes more difficult to make a diagnosis. Surgical drainage of OIM abscess is difficult because it is located at a deep part of the pelvic cavity. Read More

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November 2016

Pyopericardium with Cardiac Tamponade in a Nigerian Child with Acute Osteomyelitis.

J Cardiovasc Echogr 2017 Apr-Jun;27(2):71-73

Department of Surgery, Cardiothoracic Unit, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria.

In pyopericardium, pus accumulates in the pericardial space as a result of infection by pyogenic organisms, most common of which are and . These patients are at risk of cardiac tamponade. Apart from pericardiocentesis in the management of these patients, definitive drug treatment may pose a formidable challenge in a setting of coinfection as in patients with tuberculosis who are predisposed to secondary bacterial infections. Read More

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The Usefulness of T1-Weighted Magnetic Resonance Images for Diagnosis of Acute Leukemia Manifesting Musculoskeletal Symptoms prior to Appearance of Peripheral Blood Abnormalities.

Case Rep Pediatr 2016 18;2016:2802596. Epub 2016 Oct 18.

Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.

The patients with acute leukemia occasionally present with musculoskeletal symptoms initially, including bone pain, joint pain, muscular pain, and functional impairment. Without abnormal findings of peripheral blood cell counts or smear, the correct diagnosis tends to be delayed. Magnetic resonance imaging is often performed to examine musculoskeletal abnormalities; it can simultaneously reveal the bone marrow composition with high anatomical resolution and excellent soft tissue contrast. Read More

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October 2016

Invasive liver abscess syndrome predisposed by Klebsiella pneumoniae related prostate abscess in a nondiabetic patient: a case report.

BMC Res Notes 2016 Aug 9;9:395. Epub 2016 Aug 9.

Department of Medicine, Kaohsiung Armed Forces General Hospital, No.2, Zhongzheng 1st Road, Lingya District, Kaohsiung, 802, Taiwan, ROC.

Background: Prostate abscess is usually a complication of acute urinary tract infection. Invasive liver abscess syndrome is characterized with Klebsiella pneumoniae related multiple organ metastasis. Concomitant pyogenic liver abscess and prostate abscess have rarely been reported. Read More

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Listeria Meningitis in an Immunocompetent Child.

Pediatr Emerg Care 2017 Aug;33(8):579-581

From the *Emergency Department of Paediatrics, Departments of †Clinical Pathology and Microbiology and ‡Hematology and Oncology, and §Infectious Diseases Unit, G. Gaslini Children's Hospital, Genoa, Italy.

Listeria monocytogenes is a facultative anerobic, gram-positive bacillus that is isolated from the soil, vegetables, and wild or domestic animals. Listeria infection is usually found in the older adults, immunocompromised patients, pregnant women, and newborns, whereas it is rare in healthy infants and children. Listeria monocytogenes may cause meningitis, meningoencephalitis, brain abscess, pyogenic arthritis, osteomyelitis, and liver abscess in children. Read More

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Acute Monoarthritis of the Wrist Joint: Tuberculosis or Not?

J Wrist Surg 2016 Mar 15;5(1):77-9. Epub 2015 Dec 15.

Department of Microbiology, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India.

Background Extrapulmonary tuberculosis (EPTB) is known to have many and varied presentations. However, isolated involvement of bone with tubercular infection is uncommon. The clinical features of such infections are known to mimic chronic pyogenic osteomyelitis, Brodie abscess, or tumors, but not acute monoarthritis. Read More

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Outcome of culture-negative pyogenic vertebral osteomyelitis: comparison with microbiologically confirmed pyogenic vertebral osteomyelitis.

Semin Arthritis Rheum 2014 Oct 26;44(2):246-52. Epub 2014 Apr 26.

Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, South Korea.

Objectives: Although pyogenic vertebral osteomyelitis (PVO) with no identified microorganism is treated empirically, the clinical outcome is not well understood.

Methods: We conducted a retrospective review of patients with PVO at a tertiary-care hospital from 2000 through 2012. The study compared clinical features and outcomes of microbiologically confirmed (M-PVO) with clinically diagnosed PVO (C-PVO). Read More

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October 2014

Propionibacterium acnes and Staphylococcus lugdunensis cause pyogenic osteomyelitis in an intramedullary nail model in rabbits.

J Clin Microbiol 2014 May 5;52(5):1595-606. Epub 2014 Mar 5.

AO Research Institute Davos, Davos, Switzerland.

Propionibacterium acnes and coagulase-negative staphylococci (CoNS) are opportunistic pathogens implicated in prosthetic joint and fracture fixation device-related infections. The purpose of this study was to determine whether P. acnes and the CoNS species Staphylococcus lugdunensis, isolated from an "aseptically failed" prosthetic hip joint and a united intramedullary nail-fixed tibial fracture, respectively, could cause osteomyelitis in an established implant-related osteomyelitis model in rabbits in the absence of wear debris from the implant material. Read More

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Chronic recurrent multifocal osteomyelitis causing an acute scoliosis.

Case Rep Pediatr 2013 31;2013:649097. Epub 2013 Jul 31.

Department of Spinal Surgery, Musgrove Park Hospital, Taunton, Somerset TA1 5DA, UK.

Study Design. A Case Report. Objective. Read More

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September 2013

Streptococcal vertebral osteomyelitis: multiple faces of the same disease.

Clin Microbiol Infect 2014 Jan 24;20(1):O33-8. Epub 2013 Jul 24.

Department of Infectious Diseases, Hospital Universitari Bellvitge, Barcelona, Spain.

The role of Streptococcus species as an aetiological microorganism of vertebral osteomyelitis (VO) is considered to be of little relevance. We aimed to describe a large number of cases of streptococcal vertebral osteomyelitis (SVO), to analyze the clinical features associated with different Streptococcus species, and to compare them with a cohort of patients with VO caused by Staphylococcus aureus. An incidence study and a retrospective, multicenter, observational clinical study of cases of SVO (1991-2011) were performed. Read More

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January 2014

Serum Procalcitonin is a sensitive and specific marker in the diagnosis of septic arthritis and acute osteomyelitis.

J Orthop Surg Res 2013 Jul 4;8:19. Epub 2013 Jul 4.

Department of Orthopedics, JIPMER, Puducherry, India.

Background: Early diagnosis of Acute Osteomyelitis (OM) and Septic Arthritis (SA) is of vital importance to avoid devastating complications. There is no single laboratory marker which is sensitive and specific in diagnosing these infections accurately. Total Count, ESR and CRP are not specific as they can also be elevated in non pyogenic causes of inflammation. Read More

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Acute osteomyelitis and septic arthritis of the shoulder in premature neonates--report of two cases.

Med Pregl 2012 Jan-Feb;65(1-2):59-64

Department of Pediatrics, Institute for Child and Youth Health Care of Vojvodina.

Acute hematogenous osteomyelitis and septic arthritis are pyogenic infections of bone and joint, respectively. At the youngest age, they usually occur at the same time--hence the common name "osteoarthritis". When it comes to neonates, osteoarthritis is an infrequent finding, but it can give a permanent disability and can be even fatal unless early recognized and adequately and promptly treated. Read More

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Subacute physeal abscess: case report to illustrate treatment with a minimally invasive incision and drainage technique.

Ann R Coll Surg Engl 2012 Mar;94(2):e51-4

Princess Alexandra Hospital NHS Trust, UK.

Introduction: Brodie's abscess is a form of subacute osteomyelitis characterised by a low grade pyogenic abscess found most commonly in the metaphysis. One rare form found in children crosses the physeal growth plate and into the epiphysis. Due to the rarity of this subtype and apprehension associated with treatment of the transphyseal abscess, no clear guidance exists on its management. Read More

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