33,444 results match your criteria Osteomyelitis


Temporomandibular joint prosthesis as treatment option for mandibular condyle fractures: a systematic review and meta-analysis.

Int J Oral Maxillofac Surg 2022 Jun 23. Epub 2022 Jun 23.

Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

The aim of this study was to perform a systematic review of the literature on the temporomandibular joint (TMJ) prosthesis as a treatment option after mandibular condyle fracture. Three databases were searched (PubMed, Embase, Cochrane Library) and 2670 unique papers were identified. A total of 337 studies were included (121 case reports, 89 case series, and 127 cohort/clinical studies). Read More

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Extent of craniofacial fungal osteomyelitis in a ketoacidotic patient may predict optic nerve involvement: A case report.

Int J Surg Case Rep 2022 Jun 13;96:107299. Epub 2022 Jun 13.

Department of Head and Neck Surgery, Facial Plastic and Reconstructive Surgery, University of Texas Rio Grande Valley, United States of America.

Introduction: Mucormycosis is an opportunistic mycosis common in poorly-controlled insulin dependent diabetic patients particularly with ketoacidosis. Fungal osteomyelitis is a life-threatening condition affectation of the nose and paranasal sinuses within the orofacial region.

Presentation Of Case: We present a 63-year-old diabetic male patient with maxillary mucormycotic osteomyelitis threatening his better seeing eye and review the clinical symptoms, relevant imaging, and management. Read More

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Predictive factors in treatment response of malignant external otitis.

Eur Arch Otorhinolaryngol 2022 Jun 25. Epub 2022 Jun 25.

Otorhinolaryngology Research Center, Department of Otorhinolaryngology-Head and Neck Surgery, Amir Alam Hospital, Tehran University of Medical Sciences, North Saadi Ave, Tehran, 11457-65111, Iran.

Purpose: To evaluate the prevalence and impact of various predictive factors including diabetes control in malignant external otitis (MEO) treatment response.

Methods: In a cross-sectional study on MEO patients, we defined treatment response with three indices; ESR level decrease, hospitalization period, and systemic antifungal drug usage. The impact of diabetes control and other predictive factors on these indices have been evaluated. Read More

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A Novel Construct to Treat Destructive Osteomyelitis of the Lumbar Spine in a Patient With Pre-existing Paraplegia.

Cureus 2022 May 20;14(5):e25162. Epub 2022 May 20.

Neurological Surgery, University of Miami Miller School of Medicine, Miami, USA.

Treatment for vertebral osteomyelitis varies depending on the extent of pathology and includes both medical and surgical approaches. Pathogen-directed antibiotic therapy is often the first-line treatment, however, refractory cases or those with sepsis, segmental instability, or epidural abscess may be candidates for surgical treatment. Patients with extensive bony destruction often require a corpectomy with the placement of a cage for anterior column reconstruction. Read More

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A Journey into Animal Models of Human Osteomyelitis: A Review.

Microorganisms 2022 May 31;10(6). Epub 2022 May 31.

Department of Veterinary Medicine and Animal Sciences, University of Milan, Via dell'Università 6, 26900 Lodi, Italy.

Osteomyelitis is an infection of the bone characterized by progressive inflammatory destruction and apposition of new bone that can spread via the hematogenous route (hematogenous osteomyelitis (HO)), contiguous spread (contiguous osteomyelitis (CO)), and direct inoculation (osteomyelitis associated with peripheral vascular insufficiency (PVI)). Given the significant financial burden posed by osteomyelitis patient management, the development of new preventive and treatment methods is warranted. To achieve this objective, implementing animal models (AMs) of infection such as rats, mice, rabbits, avians, dogs, sheep, goats, and pigs might be of the essence. Read More

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Evaluation of Implant Stability and Trephination Depth for Implant Removal-An In Vitro Study.

Materials (Basel) 2022 Jun 13;15(12). Epub 2022 Jun 13.

Department of Periodontology and Dental Implants, The Maurice and Gabriela Goldschleger School of Dental Medicine, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.

Malpositioned and broken implants are usually fully osseointegrated; hence, their removal, especially from the lower arch, can be very challenging. Implant removal techniques include reverse torque and trephination. Trephination is an invasive technique that can jeopardize vital structures, cause mandibular fatigue fractures, or lead to osteomyelitis. Read More

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Antibiotic Cement Utilization for the Prophylaxis and Treatment of Infections in Spine Surgery: Basic Science Principles and Rationale for Clinical Use.

J Clin Med 2022 Jun 17;11(12). Epub 2022 Jun 17.

Department of Orthopaedic Surgery, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.

Antibiotic bone cement (ABC) is an effective tool for the prophylaxis and treatment of osteomyelitis due to the controlled, sustained release of local antibiotics. ABC has been proven to be effective in the orthopedic fields of arthroplasty and extremity trauma, but the adoption of ABC in spine surgery is limited. The characteristics of ABC make it an optimal solution for treating vertebral osteomyelitis (VO), a serious complication following spine surgery, typically caused by bacterial and sometimes fungal and parasitic pathogens. Read More

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Recurrence Rates and Its Associated Factors after Early Spinal Instrumentation for Pyogenic Spondylodiscitis: A Nationwide Cohort Study of 2148 Patients.

J Clin Med 2022 Jun 11;11(12). Epub 2022 Jun 11.

Spine Center, Department of Orthopedics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea.

Recent studies have consistently reported the safety and effectiveness of early spinal instrumentation for pyogenic spondylodiscitis. However, none of these studies investigated the recurrence rate or associated factors based on this specific group of patients. Recurrence prediction models that are not based on a homogenous cohort of patients undergoing early spinal instrumentation show theoretical limitations for clinical use. Read More

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Efficacy of Infection Eradication in Antibiotic Cement-Coated Intramedullary Nails for Fracture-Related Infections, Nonunions, and Fusions.

Antibiotics (Basel) 2022 May 25;11(6). Epub 2022 May 25.

International Center for Limb Lengthening, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, MD 21215, USA.

Antibiotic cement-coated intramedullary nails (ACCINs) are increasing in popularity as a viable solution for the treatment of fracture-related infections (FRIs), infected long bone nonunions, and arthrodeses without an external fixator. ACCINs effectively manage to fulfill three of the basic principles for eradicating osteomyelitis: dead space management, antibiotic delivery, and bone stability. We performed a retrospective review of 111 patients who were treated with ACCINs between January 2014 and December 2020. Read More

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Osteomyelitis, Oxidative Stress and Related Biomarkers.

Antioxidants (Basel) 2022 May 27;11(6). Epub 2022 May 27.

Department of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, Italy.

Bone is a very dynamic tissue, subject to continuous renewal to maintain homeostasis through bone remodeling, a process promoted by two cell types: osteoblasts, of mesenchymal derivation, are responsible for the deposition of new material, and osteoclasts, which are hematopoietic cells, responsible for bone resorption. Osteomyelitis (OM) is an invasive infectious process, with several etiological agents, the most common being , affecting bone or bone marrow, and severely impairing bone homeostasis, resulting in osteolysis. One of the characteristic features of OM is a strong state of oxidative stress (OS) with severe consequences on the delicate balance between osteoblastogenesis and osteoclastogenesis. Read More

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Global trends of dalbavancin: A bibliometric analysis.

J Clin Pharm Ther 2022 Jun 23. Epub 2022 Jun 23.

Pharmacology, Medical Sciences Department, Albacete School of Medicine, University of Castilla-La Mancha, Albacete, Spain.

WHAT IS KNOWN AND OBJECTIVE?: Dalbavancin is used against gram-positive pathogens such as Staphylococcus aureus in acute bacterial skin and skin-structure infections. METHODS: Our main goal was to identify the key articles sustaining the current knowledge of this drug's therapeutic possibilities through a bibliometric analysis of the available literature. RESULTS AND DISCUSSION: On 15 March 2021, we searched the Web of Science electronically for documents that contain within its title the term "dalbavancin. Read More

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Is oral antibiotic therapy as effective as intravenous treatment in bacterial osteomyelitis? A real-life experience.

Eur Rev Med Pharmacol Sci 2022 Jun;26(11):4069-4073

Unit of Infectious Diseases, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

Objective: Osteomyelitis is a relatively understudied disease with no standardized and evidence-based approach to treatment. We aimed to evaluate a cohort of patients with osteomyelitis, comparing the outcomes between intravenous (IV) and oral treatment.

Patients And Methods: We performed an observational retrospective study on osteomyelitis cases in adult patients seen for care between 2017 and 2019. Read More

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Missed Opportunities for Diagnosing Vertebral Osteomyelitis Caused by Influential Cognitive Biases.

Am J Case Rep 2022 Jun 22;23:e936058. Epub 2022 Jun 22.

Department of Emergency Medicine, Yamato Tokushukai Hospital, Yamato, Kanagawa, Japan.

BACKGROUND Vertebral osteomyelitis is a rare form of bone infection that requires prompt diagnosis and treatment; however, this is challenging because of the lack of specific symptoms and low sensitivity of diagnostic tests, especially in the early stages. Our case demonstrates the challenges in diagnosing vertebral osteomyelitis and provides relevant information for other physicians dealing with possible cases of vertebral osteomyelitis. CASE REPORT An 83-year-old man presented to the Emergency Department with severe low back pain of 2 weeks' duration. Read More

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Symptomatic hypercalcaemia following the use of calcium sulfate beads in periprosthetic joint infections.

N Z Med J 2022 Jun 10;135(1556):124-126. Epub 2022 Jun 10.

Department of Orthopaedic Surgery, Canterbury District Health Board.

Calcium sulfate beads (CSBs) are used as a method of delivery of antibiotics in periprosthetic joint infections, non-union and chronic osteomyelitis.[[1-3]] Symptomatic hypercalcaemia can occur as a complication following the insertion of CSBs however it is rare and few cases have been reported.[[4-7]] The cause of hypercalcaemia is poorly understood. Read More

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Use of a Porous Alumina Antibiotic-Loaded Ceramic to Treat Bone Defect and Bone Infection After Road Trauma.

J Am Acad Orthop Surg Glob Res Rev 2022 Jun 21;6(6). Epub 2022 Jun 21.

From the Orthopedic Department, Henri Mondor Hospital, Aurillac, France (Deluzarches); the Research & Development Department, I.Ceram, Limoges, France (Poli, and Barriere); and the Infectious Diseases Department, ELSAN Polyclinique de Limoges, Limoges, France (Denes).

To describe the use of a porous alumina ceramic loaded with antibiotics for the reconstruction of bilateral tibial fractures in a patient who presented with bone loss and infection after a motorcycle road injury. A 70-year-old man presented open fractures of his both tibiae (proximal involvement on the right side and diaphyseal on the left side). After initial treatment with multiple débridements and the placement of bilateral external fixators, he had bone loss to both tibiae and had developed infections of both legs with multiple organisms identified (Stenotrophomonas maltophilia, Enterobacter cloacae, and Pseudomonas aeruginosa). Read More

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A Comparison of Outcomes of Proximal and Distal Anastomosis Sites of the Facial Artery in Head and Neck Reconstruction.

J Craniofac Surg 2022 May 21;33(3):e333-e338. Epub 2021 Sep 21.

Division of Plastic and Reconstructive Surgery, Northwestern University Feinberg School of Medicine.

Abstract: Recipient vessel selection in head and neck reconstruction is based on multiple factors, including defect size and location, patient history, and vessel location, diameter, and length. The authors present a comparison of proximal and distal anastomotic sites of the facial artery. A chart review of head and neck reconstructions using the facial artery as a recipient vessel over a 7-year period was conducted. Read More

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Treatment of distal radius fractures using a cemented K-wire frame.

BMC Musculoskelet Disord 2022 Jun 20;23(1):591. Epub 2022 Jun 20.

Central Laboratory, Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.

Background: This retrospective study included an alternative treatment for types A2, A3, and B1 distal radius fractures using percutaneous fixation with a cemented K-wire frame.

Methods: From January 2017 to January 2020, 78 patients with distal radius fractures were treated with percutaneous internal fixation using a cemented K-wire frame. There were 47 male patients and 31 female patients. Read More

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Delineating the Role of the Operon in Staphylococcal Overflow Metabolism.

Front Microbiol 2022 3;13:914512. Epub 2022 Jun 3.

Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.

is an important human pathogen that can infect almost every organ system, resulting in a high incidence of morbidity and mortality. The operon is an important regulator of several staphylococcal phenotypes, including biofilm development, cell wall crosslinking, antibiotic resistance, oxidative stress, and acute and chronic implant-associated osteomyelitis. Our previous study showed that, by modulating murein hydrolase activity, the operon negatively regulates the proteases that govern cell death. Read More

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Mechanical Distribution and New Bone Regeneration After Implanting 3D Printed Prostheses for Repairing Metaphyseal Bone Defects: A Finite Element Analysis and Prospective Clinical Study.

Front Bioeng Biotechnol 2022 3;10:921545. Epub 2022 Jun 3.

Department of Orthopaedics, Peking University Third Hospital, Beijing, China.

Critical metaphyseal bone defects caused by nonunion and osteomyelitis are intractable to repair in clinical practice owing to the rigorous demanding of structure and performance. Compared with traditional treatment methods, 3D printing of customized porous titanium alloy prostheses offer feasible and safe opportunities in repairing such bone defects. Yet, so far, no standard guidelines for optimal 3D printed prostheses design and fixation mode have been proposed to further promote prosthesis stability as well as ensure the continuous growth of new bone. Read More

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The Use of Calcium Sulphate Beads in the Management of Osteomyelitis of Femur and Tibia: A Systematic Review.

Arch Bone Jt Surg 2022 Apr;10(4):320-327

Department of Trauma and Orthopaedics, Addenbrookes Major Trauma Unit, Cambridge University Hospitals, Hills Road, Cambridge, United Kingdom.

Background: Calcium sulphate is a recent alternative for delayed antibiotic elution in infected bones and joints. The purpose of this study is to evaluate the use of antibiotic impregnated calcium sulphate (AICS) beads in the management of infected tibia and femur, with regards to patient outcomes and complication rates (including reinfection rate, remission rate and union rate).

Methods: Searches of AMED, CINAHL, EMBASE, EMCARE, Medline, PubMed and Google Scholar were conducted in June 2020, with the mesh terms: "Calcium sulphate beads" or "Calcium sulfate beads" or "antibiotic beads" or "Stimulan" AND "Bone infection" or "Osteomyelitis" or "Debridement" AND "Tibia" or "Femur". Read More

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Utility of PET/Computed Tomography in Infection and Inflammation Imaging.

PET Clin 2022 Jul;17(3):533-542

Division of Diagnostic Nuclear Medicine, Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address:

The role of nuclear medicine for noninvasive assessment of infection and inflammation is well established. The role of nuclear medicine is limited to initial diagnosis, recurrence, and response assessment of infections and inflammations such as tuberculosis, sarcoidosis, vasculitis, osteomyelitis, immunoglobulin G4-related diseases, and coronavirus disease 2019, as the specificity is affected by false positivity due to physiologic fluorodeoxyglucose uptake in specific organ and nonspecific uptake in postoperative cases. PET with fludeoxyglucose F 18/CT is a well-established modality for diagnosis of fever of unknown origin helping in optimized management of the patient. Read More

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Imaging findings of vertebral osteomyelitis caused by nontuberculous mycobacterial organisms: Three case reports and literature review.

Medicine (Baltimore) 2022 Jun 17;101(24):e29395. Epub 2022 Jun 17.

Department of Radiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Rationale: Prompt diagnosis of nontuberculous Mycobacterial (NTM) vertebral osteomyelitis is challenging, yet necessary to prevent serious morbidity and mortality. Here, we report 3 cases of vertebral osteomyelitis caused by NTM with imaging findings.

Patient Concerns: Case 1, a 58-year-old male patient, was admitted to our hospital because of the presence of a pulmonary mass for 6 months with cough and chest pain. Read More

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[Effectiveness analysis of disposable skin stretch closure in treatment of difficult to close skin and soft tissue defects].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2022 Jun;36(6):760-765

Senior Department of Orthopedics, the Fourth Medical Center of Chinese PLA General Hospital, Beijing, 100048, P. R. China.

Objective: To observe the effectiveness of disposable skin stretch closure in the treatment of wounds with skin and soft tissue defects that were difficult to close.

Methods: The clinical data of 13 patients with skin and soft tissue defects that were difficult to close treated with disposable skin stretch closure and met the selection criteria between July 2021 and February 2022 were retrospectively reviewed. There were 9 males and 4 females, the age ranged from 15 to 71 years with a mean of 39. Read More

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Bone-Targeted Nanoparticle Drug Delivery System: An Emerging Strategy for Bone-Related Disease.

Front Pharmacol 2022 31;13:909408. Epub 2022 May 31.

Institute of Translational Medicine, Shanghai University, Shanghai, China.

Targeted delivery by either systemic or local targeting of therapeutics to the bone is an attractive treatment for various bone metabolism diseases such as osteoporosis, osteoarthritis, osteosarcoma, osteomyelitis, etc. To overcome the limitations of direct drug delivery, the combination of bone-targeted agents with nanotechnology has the opportunity to provide a more effective therapeutic approach, where engineered nanoparticles cause the drug to accumulate in the bone, thereby improving efficacy and minimizing side effects. Here, we summarize the current advances in systemic or local bone-targeting approaches and nanosystem applications in bone diseases, which may provide new insights into nanocarrier-delivered drugs for the targeted treatment of bone diseases. Read More

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Diabetic Maxillary Osteomyelitis: A Worrisome Vulnerability-Our Experience.

J Maxillofac Oral Surg 2022 Jun 27;21(2):590-598. Epub 2020 Apr 27.

Dept. of Prosthodontics, Rural Dental College, Loni, Ahmadnagar, Ahmednagar India.

Background: Osteomyelitis is inflammation of medullary cavities, haversian system and adjacent cortex of bone. It is devastating to patients when invasive.

Aim: The purpose of this study is to retrospectively review patients diagnosed with diabetic maxillary osteomyelitis and evaluate factors relating infection & diabetes. Read More

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Prospective comparative analysis of efficacy of local debridement with or without vancomycin impregnated calcium sulphate in chronic osteomyelitis.

J Orthop 2022 Jul-Aug;32:133-138. Epub 2022 Jun 3.

Department of Orthopedics, Vydehi Institute of Medical Sciences, Whitefield, Bangalore, Karnataka, India.

The primary objective of this study was to compare the efficacy of use of Vancomycin impregnated bioabsorbable calcium sulphate (VCS) pellets along with surgical debridement to control group without the use of calcium sulphate for chronic osteomyelitis. The secondary objective was comparing the results in different subtypes of chronic osteomyelitis.

Methods: 50 consecutive patients were enrolled in VCS group and control group based on used whether VCS was used in treatment in addition to surgical debridement or not. Read More

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The Underlying Molecular Basis and Mechanisms of Venous Thrombosis in Patients with Osteomyelitis: A Data-Driven Analysis.

Genet Res (Camb) 2022 6;2022:5672384. Epub 2022 Jun 6.

Department of Orthopaedics, Fuzhou Second Hospital of Xiamen University, School of Medicine, Xiamen University, Fuzhou 350007, China.

Objective: Osteomyelitis (OM) is one of the most risky and challenging diseases. Emerging evidence indicates OM is a risk factor for increasing incidence of venous thromboembolism (VTE) development. However, the mechanisms have not been intensively investigated. Read More

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The effectiveness of systemic antibiotics for osteomyelitis of the foot in adults with diabetes mellitus: a systematic review protocol.

J Foot Ankle Res 2022 Jun 17;15(1):48. Epub 2022 Jun 17.

Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.

Background: Osteomyelitis of the foot is a major complication of diabetes that can be limb and life threatening. Systemic antibiotic pharmacotherapy is often used first line to eradicate infection and allow restoration of devitalised bone. The aim is to conduct a systematic review of the effectiveness of systemic antibiotics on osteomyelitis of the foot in adults with diabetes mellitus. Read More

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Osteomyelitis of the thumb following a trivial trauma.

BMJ Case Rep 2022 06 16;15(6). Epub 2022 Jun 16.

Plastic Surgery, Mid Essex Hospital Services NHS Trust, Chelmsford, Essex, UK.

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Extensive multifocal emphysematous osteomyelitis of spine: A rare case and a review of literature.

Infect Disord Drug Targets 2022 Jun 14. Epub 2022 Jun 14.

Department of Medical Microbiology, PGIMER, Chandigarh.

Background: Emphysematous osteomyelitis (EO) is an extremely rare form of osteomyelitis which is complicated mainly by infection with gas-forming organisms. The common causative agents of this disease are mainly members of Enterobacteriaceae family, the most common are Escherichia coli and Klebsiella pneu¬moniae along with anaerobes. A total of 48 cases of EO have been reported in the literature till now globally and none have documented the isolation of Corynebacterium amycolatum. Read More

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