30,908 results match your criteria Osteomyelitis


Osteomyelitis, osteoradionecrosis, or medication-related osteonecrosis of the jaws? Can CBCT enhance radiographic diagnosis?

Oral Dis 2020 Jul 5. Epub 2020 Jul 5.

OMFS IMPATH research group, Department of Imaging and Pathology, Faculty of Medicine, University of Leuven, Oral & Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium.

Objective: To attempt defining differential radiographic diagnostic characteristics for osteonecrotic lesions using 2D as opposed to 3D images.

Materials And Methods: This was a cross-sectional study. Subjects presenting mandibular ostenecrotic lesions (osteomyelitis, osteoradionecrosis and medication-related osteonecrosis of the jaws) were selected and compared to a group of age and gender-matched controls, all having both cone beam computed tomographic images (CBCT) and panoramic radiographs (PANO). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/odi.13534DOI Listing

Clinical and Multimodal Imaging Findings in Disseminated Mycobacterium Chimaera.

Ophthalmol Retina 2020 Jul 2. Epub 2020 Jul 2.

Cleveland Clinic, Cole Eye Institute 9500 Euclid Avenue i-32 Cleveland, OH 44195. Electronic address:

Purpose: To characterize the ophthalmic clinical and multi-modal imaging findings of disseminated Mycobacterium chimaera infection after cardiothoracic surgery.

Design: Observational case series SUBJECTS: Four patients (eight eyes) with disseminated M. chimaera infection METHODS: Patients were evaluated with biomicroscopy, optical coherence tomography and angiography, fundus autofluorescence, fluorescein and indocyanine green angiography. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oret.2020.06.030DOI Listing

Poikiloderma with Neutropenia, Clericuzio-Type Accompanied by Loss of Digits Due to Severe Osteomyelitis.

J Clin Immunol 2020 Jul 4. Epub 2020 Jul 4.

School of Medicine, Department of Dermatology and Venereology, Hacettepe University, Ankara, Turkey.

Poikiloderma with neutropenia (PN), Clericuzio-type is a rare autosomal recessively transmitted genodermatosis caused by biallelic mutations in the USB1 gene and is characterized by early-onset poikiloderma and chronic neutropenia. Nail dystrophy, palmoplantar hyperkeratosis, hypogonadotropic hypogonadism, and recurrent infections can be associated with the disease. Herein, we present a 27-year-old Turkish male patient newly diagnosed as PN, Clericuzio-type after confirmation of a c. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10875-020-00815-5DOI Listing

Natural History and Progression of Craniofacial Fibrous Dysplasia: A Retrospective Evaluation of 114 Patients From Massachusetts General Hospital.

J Oral Maxillofac Surg 2020 May 30. Epub 2020 May 30.

Walter C. Guralnick Distinguished Professor and Chief, Emeritus, Department of Oral & Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA. Electronic address:

Purpose: The natural history of fibrous dysplasia (FD) is poorly understood. The purpose of this study was to identify differences in demographic, clinical, and radiographic characteristics among patients with craniofacial FD, including McCune-Albright syndrome (MAS), polyostotic fibrous dysplasia (PFD), and monostotic fibrous dysplasia (MFD). We hypothesized that patients with MAS would show higher disease severity, have more complications, and undergo more operations than those with PFD or MFD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.joms.2020.05.036DOI Listing

species infections in humans: a systematic review.

J Chemother 2020 Jul 3:1-11. Epub 2020 Jul 3.

Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Heraklion, Greece.

species have been recognized to cause infections in immunocompromised individuals. The purpose of this study was to systemically review all published cases of infections in humans and describe the epidemiology, microbiology, antimicrobial susceptibility, treatment and outcomes of these infections in humans. We performed a systematic review of PubMed (through 20 Octrober 2019) for studies providing epidemiological, clinical, microbiological as well as treatment data and outcomes of species infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1120009X.2020.1785742DOI Listing

Radiographic changes of chronic recurrent multifocal osteomyelitis that persisted into adulthood.

BMJ Case Rep 2020 Jul 2;13(7). Epub 2020 Jul 2.

Clinical Medicine, New York Institute of Technology College of Osteopathic Medicine at Arkansas State University, Jonesboro, Arkansas, USA

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare non-infectious autoinflammatory disorder typically seen in young women. We describe the case of a young man who presented at 13 years of age with pain in the tibia, humerus, clavicle and hip. Worsening of the condition through clinical presentation and radiographic imaging was observed over 10 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2019-232106DOI Listing

Patients' reported experiences and outcomes following surgical excision of lower limb osteomyelitis and microvascular free tissue reconstruction under 'awake' epidural anaesthesia and sedation.

Surgeon 2020 Jun 29. Epub 2020 Jun 29.

Oxford Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK. Electronic address:

Background: Orthoplastic operations for lower limb osteomyelitis (LLOM) involving microvascular free tissue reconstructions ("free-flaps") are usually performed under general anaesthesia (GA), with or without epidural anaesthesia (EA) due to concerns about the discomfort associated with prolonged surgery. However, our clinical experience supports "awake" epidural anaesthesia with sedation (EA + Sed) rather than EA + GA as a technique of choice for this type of surgery.

Methods: We used a standardised postoperative questionnaire to formally assess the experiences and outcomes for 50 patients who underwent free-flaps for LLOM under EA + Sed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.surge.2020.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323658PMC

The impact of gender on the clinical presentation, management, and surgical outcomes of patients with native-joint septic arthritis.

J Eval Clin Pract 2020 Jul 1. Epub 2020 Jul 1.

Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.

Rationale, Aims And Objectives: Approximately 20 000 cases of septic arthritis (SA) occur in the U.S. yearly. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jep.13437DOI Listing
July 2020
1.580 Impact Factor

Quality of life and mortality after surgical treatment for vertebral osteomyelitis (VO): a prospective study.

Eur Spine J 2020 Jul 1. Epub 2020 Jul 1.

Department for Spine Surgery, Klinikum Leverkusen gGmbH, Am Gesundheitspark 11, 51375, Leverkusen, Germany.

Purpose: Vertebral osteomyelitis (VO) has a high mortality and leads to chronic pain and functional disability. Surgical treatment is often necessary. To date, little is known about the consequences of surgery on patient outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00586-020-06519-zDOI Listing

Disseminated Following Open-Heart Surgery, the Heater-Cooler Unit Worldwide Outbreak: Case Report and Minireview.

Front Med (Lausanne) 2020 16;7:243. Epub 2020 Jun 16.

Université de Paris, IAME, INSERM, UMR1137, UFR de Médecine, Paris, France.

Invasive cardiovascular infections by associated with open-heart surgery have been reported worldwide since 2013. Here, we report a case of a 61 year old man, without any other particular medical background, who underwent cardiac surgery for replacing part of the ascending aorta by a bio-prosthetic graft. Eighteen months later, the patient was painful at the lower back with fever. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmed.2020.00243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308416PMC

Gallium-67 SPECT-CT for the evaluation of head and neck: preliminary study on maximum standardised uptake value in lesions, and in the parotid and submandibular glands.

Pol J Radiol 2020 6;85:e224-e229. Epub 2020 May 6.

Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan.

Purpose: The aim of this study was to investigate the gallium-67 (Ga) single-photon emission-computed tomography (SPECT-CT) for the evaluation of head and neck, especially maximum standardised uptake value (SUV) in lesions, and in the parotid and submandibular glands.

Material And Methods: Fourteen patients with head and neck lesions who underwent SPECT-CT at 72 hours after injection of Ga were included in this study. The Ga SPECT-CT parameters SUV were compared between the parotid glands and submandibular glands. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/pjr.2020.95458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315049PMC

Actinomycotic osteomyelitis with proliferative periostitis arising in the mandibular ramus: an unusual case with spontaneous bone regeneration after coronoidectomy.

Oral Radiol 2020 Jun 30. Epub 2020 Jun 30.

Department of Oral and Maxillofacial Surgery/Orthodontics, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.

Actinomycotic osteomyelitis is an aggressive and persistent disease capable of invading and destroying bone, and chronic osteomyelitis with proliferative periostitis represents new bone formation with periosteal reaction. We report a rare case of actinomycotic osteomyelitis with proliferative periostitis arising in the mandibular ramus and spontaneous bone regeneration after coronoidectomy. A 14-year-old girl was referred for swelling in the right parotid-masseteric region and severe trismus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11282-020-00462-xDOI Listing

Management of a Difficult-to-Treat Diabetic Foot Wound Complicated by Osteomyelitis: A Case Study.

Case Rep Surg 2020 15;2020:3971581. Epub 2020 Jun 15.

Division of Plastic Surgery, Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Introduction: Diabetic ulcers are a major health issue worldwide, causing significant economic burdens and affecting both the patient and the society as a whole. Predisposing factors in diabetic patients, known as the pathogenic triad, comprise trauma, ischemia, and neuropathy. Regardless of the cause, correct diagnosis and prompt treatment are essential in the management of leg ulcers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/3971581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313145PMC

Two-component signaling pathways modulate drug resistance of (Review).

Biomed Rep 2020 Aug 9;13(2). Epub 2020 Jun 9.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

As the issues surrounding antibiotic-resistant strains of () are becoming increasingly serious concerns, it is imperative to investigate new therapeutic targets to successfully treat patients with infections. The two-component signal transduction system is one of the primary pathways by which bacteria adapt to the external environment, and it serves an important role in regulating virulence gene expression, cell wall synthesis, biofilm formation and bacterial activity. There are 17 two-component signaling pathways in , among which WalKR/VicSR/YycGF, AirSR/YhcSR, vancomycin resistance associated regulator/sensor and LytRS have been demonstrated to serve vital roles in regulating bacterial resistance, and are hypothesized to be potential targets for the treatment of infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/br.2020.1312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323452PMC

Regenerative effect of recombinant human bone morphogenetic protein-2/absorbable collagen sponge (rhBMP-2/ACS) after sequestrectomy of medication-related osteonecrosis of the jaw (MRONJ).

J Korean Assoc Oral Maxillofac Surg 2020 Jun;46(3):191-196

Department of Oral and Maxillofacial Surgery, Institute of Oral Health Science, Ajou University School of Medicine, Suwon, Korea.

Objectives: Beyond the original application approved by the U.S. Food and Drug Administration, recombinant human bone morphogenetic protein-2 (rhBMP-2) is used for medication-related osteonecrosis of the jaw (MRONJ) treatment because of its bone remodeling enhancement properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5125/jkaoms.2020.46.3.191DOI Listing

Treatment of osteoarticular, cardiovascular, intravascular catheter-related, and other complicated infections with dalbavancin and oritavancin: a systematic review.

Int J Antimicrob Agents 2020 Jun 27:106069. Epub 2020 Jun 27.

University of Georgia College of Pharmacy, Albany, GA, 31701, USA. Electronic address:

Background: There is increasing interest in using oritavancin and dalbavancin for complicated Gram-positive infections as an alternative to in-hospital intravenous or outpatient antimicrobial therapy.

Objective: To evaluate the efficacy and safety of long-acting lipoglycopeptides (laLGPs) in patients with osteoarticular, cardiovascular, intravascular catheter-related, and other complicated infections.

Methods: A systematic literature search using was performed using "dalbavancin" and "oritavancin" as search terms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijantimicag.2020.106069DOI Listing

Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.

Mater Sci Eng C Mater Biol Appl 2020 Oct 19;115:111101. Epub 2020 May 19.

INQUISUR-UNS-CONICET, Bahía Blanca 8000, Argentina.

Bone substitute materials based on bioceramics and polymers have evolved shifting from a passive role where they are merely accepted by the body; to an active role, where they respond to particular environmental conditions or to different types of cues generating suitable integration (osseointegration for this case) inside the host tissue. In this work, two types of composite materials based on a bioceramic (synthetic nano-hydroxyapatite, HA) and a biopolymer (sodium alginate, ALG) have been designed and assessed for promoting the bone regeneration. These materials were loaded with ciprofloxacin (CIP) for obtaining, not only a suitable material for a filling but with antibacterial properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msec.2020.111101DOI Listing
October 2020

Localized mandibular infection affects remote in vivo bioreactor bone generation.

Biomaterials 2020 Jun 23;256:120185. Epub 2020 Jun 23.

Department of Bioengineering, Rice University, Houston, TX, USA. Electronic address:

Mandibular reconstruction requires functional and aesthetic repair and is further complicated by contamination from oral and skin flora. Antibiotic-releasing porous space maintainers have been developed for the local release of vancomycin and to promote soft tissue attachment. In this study, mandibular defects in six sheep were inoculated with 10 colony forming units of Staphylococcus aureus; three sheep were implanted with unloaded porous space maintainers and three sheep were implanted with vancomycin-loaded space maintainers within the defect site. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biomaterials.2020.120185DOI Listing

Identification of a novel gene argJ involved in arginine biosynthesis critical for persister formation in Staphylococcus aureus.

Discov Med 2020 Jan-Feb;29(156):65-77

Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

Staphylococcus aureus can cause both acute and recurrent persistent infections such as peritonitis, endocarditis, abscesses, osteomyelitis, and chronic wound infections. Effective therapies to treat persistent disease are paramount. However, the mechanisms of S. Read More

View Article

Download full-text PDF

Source

Osteomyelitis Increases the Rate of Amputation in Patients with Type 2 Diabetes and Lower Extremity Burns.

J Burn Care Res 2020 Jun 29. Epub 2020 Jun 29.

Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

In patients with diabetes mellitus (DM), amputation rates exceed 30% when lower extremity osteomyelitis is present. We sought to determine the rate of osteomyelitis and any subsequent amputation in our patients with DM and lower extremity burns. We performed a single site, retrospective review at our burn center using the institutional burn center registry, linked to clinical and administrative data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jbcr/iraa106DOI Listing

Surgical approaches to the petrous apex.

World J Otorhinolaryngol Head Neck Surg 2020 Jun 3;6(2):106-114. Epub 2020 Jun 3.

Department of Otorhinolaryngology - Head and Neck Surgery, Albert Einstein College of Medicine, Bronx, NY, USA.

The petrous apex is a difficult to reach surgical area due to its deep position in the skull base and many vital surrounding structures. Petrous apex pathology ranges from extradural cholesterol granulomas, cholesteatomas, asymmetric pneumatization, and osteomyelitis to intradural meningiomas and schwannomas. Certain lesions, such as cholesterol granulomas, can be managed with drainage while neoplastic lesions must be completely resected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wjorl.2019.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296478PMC

NF-κB/TWIST1 Mediates Migration and Phagocytosis of Macrophages in the Mice Model of Implant-Associated Osteomyelitis.

Front Microbiol 2020 12;11:1301. Epub 2020 Jun 12.

Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

() infection-induced osteomyelitis is a great challenge in clinic treatment. Identification of the essential genes and biological processes that are specifically changed in mononuclear cells at an early stage of osteomyelitis is of great clinical significance. Based on transcriptional dataset GSE16129 available publicly, a bioinformatic analysis was performed to identify the differentially expressed genes of osteomyelitis caused by infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2020.01301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304240PMC

Mandibular osteomyelitis after hyaluronic acid injection.

J Cosmet Dermatol 2020 Jun 27. Epub 2020 Jun 27.

Department of Plastic surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Background: Mandibular osteomyelitis after filler injection is extremely rare. We reported a case of mandibular osteomyelitis after hyaluronic acid injection.

Patients: A 33-year-old woman received 1ml hyaluronic acid injection on her chin one year ago, after which her chin kept swelling and painful, and gradually ulcerated with pus flowing out. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.13575DOI Listing

Clinical Outcomes and Economic Impact of Oritavancin for Gram-Positive Infections: A Single Academic Medical Center Health System Experience.

Drugs Real World Outcomes 2020 Jun;7(Suppl 1):13-19

Department of Pharmacy, University of Wisconsin Health, 600 Highland Avenue, MC 1530, Madison, WI, 53792, USA.

Background: Vancomycin treatment of complicated Gram-positive infections is associated with laboratory monitoring, nephrotoxicity, and multiple daily dosing. Oritavancin, a lipoglycopeptide antibiotic with a once-weekly dosing strategy and similar but slightly broader spectrum of activity, presents several opportunities over vancomycin to improve compliance and convenience for the patient. Minimal real-world clinical and acquisition cost data in the inpatient setting and clinical data surrounding multiple dosing in the outpatient setting have limited oritavancin use despite its potential logistic advantages. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40801-020-00192-wDOI Listing

How is the microbial diagnosis of bacterial vertebral osteomyelitis performed? An 11-year retrospective study.

Eur J Clin Microbiol Infect Dis 2020 Jun 26. Epub 2020 Jun 26.

Infectious and Tropical Diseases Unit, Grenoble-Alpes University Hospital, Grenoble, France.

Vertebral osteomyelitis (VOM) is often diagnosed with delays, resulting in poorer outcomes. Microbial documentation is particularly challenging and obtained using blood cultures (BCs) and vertebral biopsies (VBs; CT-guided or surgical). We retrospectively analysed VOM cases in a tertiary reference centre between 2004 and 2015, focusing on how and how quickly microbiological diagnosis was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10096-020-03929-1DOI Listing

Spinal epidural abscess caused by non-typhoidal Salmonella: A case report and literature review.

J Infect Chemother 2020 Jun 23. Epub 2020 Jun 23.

Department of Pathogen, Infection and Immunity, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan.

Non-typhoidal Salmonellae are Gram negative bacilli commonly causing self-limiting gastroenteritis, representing a public health issue particularly in tropical countries. Further, the epidemiology of invasive infection by non-typhoidal Salmonella species is poorly understood. Herein, we presented a case of an unusual Salmonella enterica subsp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jiac.2020.05.016DOI Listing

Real-World Use of Oritavancin for the Treatment of Osteomyelitis.

Drugs Real World Outcomes 2020 Jun;7(Suppl 1):46-54

GST Micro LLC, 8356 Town Hall Court, Henrico, VA, 23231, USA.

Osteomyelitis is a difficult-to-treat disease that can require both surgical debridement and a prolonged course of antimicrobial therapy. Current standard of care for the antimicrobial treatment of osteomyelitis is fraught with multiple challenges and limitations. Patients typically require the insertion of an indwelling catheter for single or multiple daily intravenous antibiotic infusions for up to 6 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40801-020-00194-8DOI Listing

Treatment of Acute Osteomyelitis with Once-Weekly Oritavancin: A Two-Year, Multicenter, Retrospective Study.

Drugs Real World Outcomes 2020 Jun;7(Suppl 1):41-45

Metro Infectious Disease Consultants, 901 McClintock Dr., Ste. 202, Burr Ridge, IL, USA.

Background: Acute osteomyelitis is typically caused by Gram-positive pathogens, commonly antibiotic-resistant Staphylococcus species. Standard antibiotic treatment is challenging due to required multiple daily doses, therapeutic drug monitoring, and parenteral administration for at least 4 weeks. Oritavancin is a long-acting lipoglycopeptide antibiotic approved as a single 1200 mg dose for the treatment of adult patients with acute bacterial skin and skin structure infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40801-020-00195-7DOI Listing

Whole-body magnetic resonance imaging in children - how and why? A systematic review.

Pediatr Radiol 2020 Jun 25. Epub 2020 Jun 25.

Department of Radiology and Intervention, Unit for Paediatric Radiology, Oslo University Hospital, Oslo, Norway.

Whole-body magnetic resonance imaging (MRI) is increasingly being used for a number of indications. Our aim was to review and describe indications and scan protocols for diagnostic value of whole-body MRI for multifocal disease in children and adolescents, we conducted a systematic search in Medline, Embase and Cochrane for all published papers until November 2018. Relevant subject headings and free text words were used for the following concepts: 1) whole-body, 2) magnetic resonance imaging and 3) child and/or adolescent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00247-020-04735-9DOI Listing

Amyloid Goiter: A Case Report and Review of the Literature.

Saudi J Med Med Sci 2020 May-Aug;8(2):151-155. Epub 2020 Apr 17.

Clinic for Surgery, University Clinical Centre Tuzla, Faculty of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina.

Amyloid goiter is a very rare manifestation of amyloidosis. Here, we describe the case of a 40-year-old male, who presented with upper airway obstructive symptoms including hoarseness and breathing difficulty, to highlight the clinical and pathological features of secondary amyloidosis of the thyroid gland and the difficulties in making a preoperative diagnosis. The patient had previously been wounded in the war in Bosnia, which resulted in the right kidney being surgically removed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/sjmms.sjmms_308_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305682PMC

Pediatric Hand Infections.

Authors:
Joseph F Styron

Hand Clin 2020 Aug;36(3):381-386

9500 Euclid Avenue Mail Code A40, Cleveland, OH 44195, USA. Electronic address:

Infections are an important source of morbidity in pediatric hands that come from frequent exposure to mouths and other dangers while exploring the world. Although Staphylococcus aureus is still the most common organism in pediatric hand infections, it is less common than in adults because pediatric patients are more likely to develop mixed aerobic/anaerobic infections or group A Streptococcus pyogenes infection. Pediatric patients with open physes potentially may sustain Seymour fractures of the distal phalanges that may become infected and sources for osteomyelitis if not recognized early. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hcl.2020.03.012DOI Listing

Complications of Hand Infections.

Hand Clin 2020 Aug;36(3):361-367

Department of Orthopaedics and Sports Medicine, Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140, USA. Electronic address:

Although most hand infections can be eradicated by appropriate management with return to normal function, complications are frequently encountered. Common complications include stiffness, osteomyelitis, and large soft tissue defects that require complex wound management. Risk factors for hand infections include an immunocompromised host state, as is the case in patients with diabetes mellitus or human immunodeficiency virus/AIDS, as well as those on immunosuppressive medications for autoimmune disorders or following organ transplantation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hcl.2020.03.010DOI Listing

Squamous cell carcinoma originated from chronic osteomyelitis sinus tract in tibia.

Authors:
Ahmet Aslan

Jt Dis Relat Surg 2020 18;31(2):405-407. Epub 2020 Jun 18.

Alanya Alaaddin Keykubat Üniversitesi, Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Kliniği, 07425 Alanya, Antalya, Türkiye.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5606/ehc.2020.75084DOI Listing

Skull Base Fungal Osteomyelitis: A Case Report and Review of the Literature.

Ear Nose Throat J 2020 Jun 25:145561320936006. Epub 2020 Jun 25.

Department of Neuroscience, Reproductive and Odontostomatological Sciences, Otorhinolaryngology-Head and Neck Surgery Unit, University of Naples Federico II, Italy.

Skull base osteomyelitis (SBO) is an invasive infection refractory to therapy, closely linked with malignant otitis externa (MOE). It is characterized by a mild clinical presentation that can delay cross-sectional imaging considered as the key to revealing it. Skull base osteomyelitis typically affects elderly diabetics and immunocompromised patients (>70 years). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0145561320936006DOI Listing

EGFR/FAK and c-Src signaling pathways mediate the internalization of Staphylococcus aureus by osteoblasts.

Cell Microbiol 2020 Jun 25:e13240. Epub 2020 Jun 25.

Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Internalization of Staphylococcus aureus (S. aureus) in osteoblasts plays a critical role in the persistence and recurrence of osteomyelitis, the mechanisms involved in this process remain largely unknown. In the present study, evidence of internalized S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cmi.13240DOI Listing

Internal fixation of delayed union of fracture with chronic osteomyelitis due to Staphylococcus epidermidis: A case report.

Ann Med Surg (Lond) 2020 Aug 11;56:56-60. Epub 2020 Jun 11.

Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia.

Introduction: The most feared and challenging complication in treating patients with musculoskeletal trauma is infection after fracture fixation, which can delay healing and, in turn, result in permanent functional loss of limbs or even amputation.

Case Presentation: Here, we describe a case in which a patient presented with stage 4 chronic osteomyelitis on the right tibia and fibula. To treat the late infection by eradicating or reducing the infection, it was recommended to replace the internal fixation with surgical debridement for 6 weeks and antibiotics for 6-12 weeks until the internal fixation device could be removed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amsu.2020.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305371PMC

Fibroblast Growth Factor 23 and Risk of Hospitalization with Infection in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort (CRIC) Study.

J Am Soc Nephrol 2020 Jun 23. Epub 2020 Jun 23.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Background: Risk of infectious disease is increased among individuals with CKD. Fibroblast growth factor 23 (FGF23) is often elevated in CKD, and may impair immune function directly or indirectly through proinflammatory and vitamin D-suppressing pathways. Whether FGF23 is associated with risk of infection has not been evaluated in a CKD population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2019101106DOI Listing

The optimal management of Seymour fractures in children and adolescents: a systematic review protocol.

Syst Rev 2020 Jun 23;9(1):150. Epub 2020 Jun 23.

St Thomas' Hospital, London, UK.

Background: Seymour fractures are open, displaced juxta-epiphyseal fractures of the distal phalanx, with an overlying nail bed laceration that occur in children and adolescents with an open physis. This fracture occurs rarely, but its potential consequences are clinically significant. Due to anatomical particulars and proximity to the growth plate, this open fracture may result in soft tissue infection and osteomyelitis, leading to growth arrest and persistent mallet deformity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13643-020-01407-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313162PMC

CORR Insights®: Does Universal Insurance and Access to Care Influence Disparities in Outcomes for Pediatric Patients with Osteomyelitis?

Authors:
Keith R Gabriel

Clin Orthop Relat Res 2020 Jul;478(7):1440-1442

K. R. Gabriel, Associate Professor, SIU School of Medicine, Department of Surgery, Division of Orthopaedics and Rehabilitation, Springfield, IL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CORR.0000000000001051DOI Listing

A severe presentation of chronic non-infectious osteomyelitis associated with ulcerative colitis: a case report.

BMC Pediatr 2020 Jun 22;20(1):304. Epub 2020 Jun 22.

Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, West Virginia University Health Sciences Center, PO Box 9214, Morgantown, WV, 26506, USA.

Background: Chronic Non-Infectious Osteomyelitis (CNO) is a chronic, relapsing, self-limiting inflammation of the bone. Although it is rare, CNO has been associated with inflammatory bowel disease and frequently precedes the initial diagnosis. We present a case of CNO in a patient with known ulcerative colitis in clinical remission who presented with purulent multifocal joint effusions in the setting of elevated inflammatory markers and fever suspicious for bacterial osteomyelitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-020-02215-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310113PMC

Fungal arthritis with adjacent osteomyelitis caused by Candida pelliculosa: a case report.

BMC Infect Dis 2020 Jun 22;20(1):438. Epub 2020 Jun 22.

Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: Candida sp. osteoarticular infection is rare and most often due to hematogenous seeding during an episode of candidemia in immunocompromised patients. However, the diagnosis can be delayed in patients with subtle symptoms and signs of joint infection without a concurrent episode of candidemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-020-05171-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310117PMC

Gentamicin Vestibulotoxicity: Further Insights From a Large Clinical Series.

Otol Neurotol 2020 Jun 16. Epub 2020 Jun 16.

Department of Otolaryngology-Head and Neck Surgery, University Health Network.

Objective: To review insights gained from a 21-year experience with gentamicin-induced vestibulotoxicity including differences in vestibulotoxicity between single daily dosing (SDD) and multiple daily dosing (MDD) regimens.

Study Design: Retrospective case series.

Setting: Tertiary care center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MAO.0000000000002698DOI Listing

Atypical Manifestations of Cat-Scratch Disease, United States, 2005-2014.

Emerg Infect Dis 2020 Jul;26(7):1438-1446

Atypical manifestations that can be severe and difficult to diagnosis develop in 5%-20% of patients with cat-scratch disease. To clarify the epidemiology of atypical cat-scratch disease in the United States, we analyzed data from the 2005-2014 MarketScan national health insurance claims databases by using the International Classification of Diseases, 9th Revision, Clinical Modification, codes for cat-scratch disease and selected atypical manifestations: retinitis/neuroretinitis, conjunctivitis, neuritis, encephalitis, hepatosplenic disease, osteomyelitis, erythema nodosum, and endocarditis. Atypical cat-scratch disease accounted for 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3201/eid2607.200034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323523PMC

Pediatric pharmaceutical care with anti-infective medication in a patient with acute hematogenous osteomyelitis caused by methicillin-resistant .

Int J Immunopathol Pharmacol 2020 Jan-Dec;34:2058738420925713

Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, P.R. China.

The infection of the bone marrow system caused by methicillin-resistant (MRSA) leads to a variety of common diseases which usually occur in children under the age of 12. Vancomycin (VCM) is the first-line therapy for MRSA-caused serious infections such as bacteremia, infective endocarditis, osteomyelitis, meningitis, pneumonia, and severe skin and soft-tissue infection (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2058738420925713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307395PMC

Early Advanced Therapy for Diabetic Foot Ulcers in High Amputation Risk Veterans: A Cohort Study.

Int J Low Extrem Wounds 2020 Jun 22:1534734620928151. Epub 2020 Jun 22.

Coles Reinstein PLLC, Boise, ID, USA.

Veterans with diabetic foot ulcers (DFUs) represent the highest percentage of lower extremity amputations (LEAs) within the Veterans Affairs (VA) population. Many veterans have additional risk factors for amputation. Few studies focus on advanced therapies for this population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1534734620928151DOI Listing

Prevalence of dental and mandibular disorders in culled sheep in Spain.

Aust Vet J 2020 Jun 21. Epub 2020 Jun 21.

Animal Pathology Department, Instituto Agroalimentario de Aragón-IA2 (Universidad de Zaragoza-CITA), Veterinary Faculty of Zaragoza, C/Miguel Servet 177, 50013 Zaragoza, Spain.

At the slaughterhouse, 1465 culled sheep heads were studied in order to identify disorders of the mandibular cheek teeth. Of these, 227 (15.5%) had evidence of osteomyelitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/avj.12990DOI Listing

Physiologically Based Population Pharmacokinetic Modeling Approach for Ciprofloxacin in Bone of Patients Undergoing Orthopedic Surgery.

ACS Pharmacol Transl Sci 2020 Jun 25;3(3):444-454. Epub 2020 May 25.

IBMP-Institute for Biomedical and Pharmaceutical Research, Nürnberg-Heroldsberg, 90562, Germany.

Ciprofloxacin is highly active against bacteria that commonly cause bone infections. However, the time-course of ciprofloxacin in bone has not been characterized using population pharmacokinetic modeling. Thirty-nine patients received a 1-h infusion of 400 mg of ciprofloxacin before orthopedic surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsptsci.0c00045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296545PMC

Acute hematogenous pelvic osteomyelitis: appropriate timing for MRI.

Pediatr Int 2020 Jun 19. Epub 2020 Jun 19.

Department of Radiology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo, Japan, 157-8535.

Background: The precise time of appearance of bone marrow edema in acute hematogenous pelvic osteomyelitis (AHPO) is unknown. The purpose of present research is to clarify the time of appearance of bone marrow edema on MRI in AHPO. Our hypothesis was that onset is slower than in long-bone osteomyelitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ped.14353DOI Listing

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.

Nat Commun 2020 Jun 19;11(1):3150. Epub 2020 Jun 19.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.

MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a single missense mutation, Mlkl, that alters the two-helix 'brace' that connects the killer four-helix bundle and regulatory pseudokinase domains. This confers constitutive, RIPK3 independent killing activity to MLKL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-020-16819-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305203PMC
June 2020
10.742 Impact Factor