29,539 results match your criteria Osteomyelitis


Endovascular treatment of a ruptured thoracic aortic pseudoaneurysm secondary to Pott disease during a spine surgery: A case report and a literature review.

Medicine (Baltimore) 2019 Apr;98(16):e15306

Department of Orthopedic Surgery.

Rationale: The coexistence of a tuberculous aortic pseudoaneurysm and Pott disease in patients with a history of tuberculosis (TB) is relatively rare, and the treatment strategies remain still controversial.

Patient Concerns: A 57-year-old female patient with a history of primary pulmonary TB presented with symptoms of breathlessness, chest pain, weight loss, and fever. Magnetic resonance imaging (MRI) and computed tomography (CT) showed a thoracic aortic pseudoaneurysm secondary to Pott disease at T11/12 level. Read More

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http://dx.doi.org/10.1097/MD.0000000000015306DOI Listing

Stopping antibiotics after surgical amputation in diabetic foot and ankle infections-A daily practice cohort.

Endocrinol Diabetes Metab 2019 Apr 6;2(2):e00059. Epub 2019 Feb 6.

Service of Infectious Diseases Geneva University Hospitals Geneva Switzerland.

Objective: The appropriate duration of antibiotic therapy for diabetic foot infections (DFI) after surgical amputations in toto is debated. There are discrepancies worldwide.

Methods: Using a clinical pathway for adult DFI patients (retrospective cohort analysis), we conducted a cluster-controlled Cox regression analysis. Read More

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http://dx.doi.org/10.1002/edm2.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458464PMC

Osteomyelitis due to methicillin-resistant successfully treated by an oral combination of minocycline and trimethoprim-sulfamethoxazole.

SAGE Open Med Case Rep 2019 9;7:2050313X19841465. Epub 2019 Apr 9.

Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.

Most of the anti-methicillin-resistant drugs available in Japan are administered intravenously, except for linezolid, which can also be administered orally. Here, we report a lupus patient with methicillin-resistant induced osteomyelitis. Linezolid had to be stopped due to severe anemia. Read More

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http://dx.doi.org/10.1177/2050313X19841465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457016PMC

Comparison of Vacuum-Assisted Closure Therapy and Conventional Dressing on Wound Healing in Patients with Diabetic Foot Ulcer: A Randomized Controlled Trial.

Niger J Surg 2019 Jan-Jun;25(1):14-20

Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Background: Vacuum-assisted closure (VAC) therapy has been shown to be beneficial in a variety of wounds. However, evidence of its benefit in diabetic foot ulcers (DFUs), especially with respect to Indian population, is sparse.

Methodology: This randomized controlled trial included DFUs of Wagner's Grades 1 and 2. Read More

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http://www.nigerianjsurg.com/text.asp?2019/25/1/14/253776
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http://dx.doi.org/10.4103/njs.NJS_14_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452767PMC
April 2019
1 Read

Revision of Syndesmosis Screw Fixation.

Foot Ankle Spec 2019 Apr 22:1938640019843328. Epub 2019 Apr 22.

College of Medicine and Life Sciences, University of Toledo, Toledo, Ohio (KRB, RJ, DY, SD).

Background: Many syndesmosis screw fixations do not achieve success at the first attempt. Currently, there are no data available to evaluate revision of syndesmosis screw failure.

Methods: A total of 160 consecutive patients who underwent syndesmosis screw fixation from 2014 to 2016 were reviewed. Read More

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http://dx.doi.org/10.1177/1938640019843328DOI Listing

Fungal Malignant Otitis Externa Involves a Cascade of Complications Culminating in Pseudoaneurysm of Internal Maxillary Artery: A Case Report.

Am J Case Rep 2019 Apr 21;20:562-566. Epub 2019 Apr 21.

Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.

BACKGROUND Pseudomonal infection is the most common cause of malignant otitis externa (MOE), which typically affects elderly diabetic patients. Fungi are a rare cause of MOE. MOE can be life-threatening if not recognized and treated promptly. Read More

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https://www.amjcaserep.com/abstract/index/idArt/913469
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http://dx.doi.org/10.12659/AJCR.913469DOI Listing
April 2019
1 Read

Percutaneous CT guided bone biopsy for suspected osteomyelitis: Diagnostic yield and impact on patient's treatment change and recovery.

Eur J Radiol 2019 May 8;114:85-91. Epub 2019 Feb 8.

Radiology, UT Southwestern Medical Center, Dallas, TX, USA; Orthopedics, UT Southwestern Medical Center, Dallas, TX, USA.

Aim: To evaluate the utility of percutaneous CT guided bone biopsy (PCBB) for suspected osteomyelitis (OM) and its eventual impact on patient management and recovery.

Material And Methods: Patients who received a PCBB for suspected osteomyelitis from years 2012-2018. Patient demographics, lesion location, ulcer grade, signs of toxemia, serology, wound and blood cultures, bone biopsy and cross-sectional imaging results were recorded. Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.01.032DOI Listing

Pin tract infection prophylaxis and treatment.

Injury 2019 Apr 1. Epub 2019 Apr 1.

Microbiology Unit, Hospital Universitario Costa del Sol, University of Malaga, Marbella (Malaga), Spain.

Pin tract infection in external fixation (ExFix) is a frequent finding which can eventually lead to loosening, osteomyelitis and loss of fixation. Its diagnosis is based on high empiricism and low validity, although it is possible to distinguish between minor and major infection. The first is limited to soft tissues, whereas the latter includes bone involvement. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00201383193016
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http://dx.doi.org/10.1016/j.injury.2019.03.044DOI Listing
April 2019
1 Read

Outcome of Islanded Gastrocnemius Musculocutaneous Flap in Orthopaedic Practice.

Malays Orthop J 2019 Mar;13(1):25-29

Department of Surgery, International Islamic University of Malaysia, Kuantan, Malaysia.

Large wounds in the leg require combination of local flaps or free flap for wound coverage. Gastrocnemius musculocutaneous flap (GMCF) allows a large wound to be covered by a single local flap. However, the conventional GMCF is often associated with donor site morbidity where the exposed soleus raphe causes poor uptake of the skin graft. Read More

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http://www.morthoj.org/2019/v13n1/islanded-gastrocnemius.pdf
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http://dx.doi.org/10.5704/MOJ.1903.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459037PMC
March 2019
1 Read

Treatment algorithm for spontaneous spinal infections: A review of the literature.

J Craniovertebr Junction Spine 2019 Jan-Mar;10(1):3-9

Department of Human Neurosciences, Division of Neurosurgery, Sapienza University of Rome, Rome, Italy.

Background: Primary spinal infections are rare pathologies with an estimated incidence of 5% of all osteomyelitis. The diagnosis can be challenging and this might result in a late identification. The etiological diagnosis is the primary concern to determine the most appropriate treatment. Read More

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http://dx.doi.org/10.4103/jcvjs.JCVJS_115_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469318PMC

Applicability of histopathological osteomyelitis evaluation score (HOES) in chronic osteomyelitis of the foot - A feasibility study.

Foot Ankle Surg 2019 Apr 2. Epub 2019 Apr 2.

Dept. of Orthopaedics, Sri Sathya Sai Institute of Higher Medical Sciences - Prasanthigram, Puttaparthi, Andhra Pradesh, 515134 India. Electronic address:

Background: Diagnosis and classification of chronic osteomyelitis is not based on any objective criteria. None of the available methods for this is completely reliable. Tienmann et al. Read More

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http://dx.doi.org/10.1016/j.fas.2019.03.008DOI Listing

Pancytopenia as a Consequence of Sepsis and Intravenous Antibiotic Drug Toxicity.

Cureus 2019 Feb 1;11(2):e3994. Epub 2019 Feb 1.

Internal Medicine, Ocala Regional Medical Center/ University of Central Florida College of Medicine, Ocala, USA.

This case involves a 62-year-old male with a prior history of epidural abscess and L1-L2 osteodiscitis who was admitted because of low back pain. The patient was previously treated for methicillin-susceptible Staphylococcus aureus (MSSA) discitis in the L1/L2 vertebral region with intravenous (IV) nafcillin through a peripherally inserted central catheter (PICC). However, he returned after four months with recurrent low back pain along with chills and fever. Read More

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https://www.cureus.com/articles/17399-pancytopenia-as-a-cons
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http://dx.doi.org/10.7759/cureus.3994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443538PMC
February 2019
2 Reads

Osteosarcoma of the Proximal Femur Mimicking Septic Arthritis of the Hip: A diagnostic dilemma.

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e545-e548. Epub 2019 Mar 28.

Department of Orthopaedics, Armed Forces Hospital, Salalah, Oman.

Septic arthritis is a surgical emergency requiring prompt drainage of the accumulation of pus in the joint. We report an eight-year-old boy who was referred to the Armed Forces Hospital, Salalah, Oman, in 2016 with limping and pain in his right hip along with an abduction deformity. He was initially diagnosed with synovitis and underwent conservative management. Read More

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https://journals.squ.edu.om/index.php/squmj/article/view/300
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http://dx.doi.org/10.18295/squmj.2018.18.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443267PMC
November 2018
2 Reads

Fosfomycin: the characteristics, activity, and use in critical care.

Ther Clin Risk Manag 2019 27;15:525-530. Epub 2019 Mar 27.

Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran,

Fosfomycin (CHOP) is a phosphonic acid derivative representing an epoxide class of antibiotics. The drug is a re-emerging bactericidal antibiotic with a wide range of actions against several Gram-positive and Gram-negative bacteria. Among the existing antibacterial agents, fosfomycin has the lowest molecular weight (138 Da), which is not structurally associated with other classes of antibiotics. Read More

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http://dx.doi.org/10.2147/TCRM.S199119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441553PMC
March 2019
3 Reads

Response to Early-onset Pamidronate Treatment in Chronic Non-Bacterial Osteomyelitis: A Retrospective Single Center Study.

J Rheumatol 2019 Apr 15. Epub 2019 Apr 15.

From the Department of Rheumatology, Aarhus University Hospital, Denmark; Department of Radiology, Aarhus University Hospital, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital, Denmark. Aarhus University has financially supported this work. Address correspondence to Caroline Marie Andreasen, MD, Department of Rheumatology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark. E-mail:

Objective: Chronic non-bacterial osteomyelitis (CNO) is a sterile inflammatory bone disorder with an unpredictable course of disease. The aim of the present study was to assess clinical and radiological disease activity in children with CNO including response to early-onset pamidronate treatment in CNO.

Methods: We conducted a single center retrospective study of children fulfilling the Bristol Criteria for CNO. Read More

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http://dx.doi.org/10.3899/jrheum.181254DOI Listing

Osteomyelitis in limb amputated by amniotic band sequence.

BMJ Case Rep 2019 Apr 14;12(4). Epub 2019 Apr 14.

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

A preterm (30 week) neonate with below-knee amputation (right lower limb), constriction rings and syndactyly, subsequent to amniotic band sequence, developed pus discharge from the right tibial stump. The neonate did not have clinical features of systemic sepsis. Blood culture was sterile. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22858
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http://dx.doi.org/10.1136/bcr-2018-228588DOI Listing
April 2019
2 Reads

Efficacy of HRCT Imaging vs SPECT/CT Scans in the Staging of Malignant External Otitis.

Otolaryngol Head Neck Surg 2019 Apr 16:194599819838834. Epub 2019 Apr 16.

2 Department of Nuclear Medicine, Kasturba Medical College and Hospital, Manipal Academy of Higher Education, Manipal, India.

Objective: The prognosis of patients with malignant external otitis (MEO) depends on the extent of the inflammatory changes in the temporal bone and skull base. The efficacy of high-resolution computed tomography (HRCT) imaging in accurately assessing the extent of disease is compared with that of single-photon emission computed tomography/computed tomography (SPECT/CT) scan.

Study Design: A clinical chart review was conducted with medical records and radiologic images. Read More

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http://dx.doi.org/10.1177/0194599819838834DOI Listing
April 2019
1 Read

Pins and rubbers traction system for fractures of the proximal interphalangeal joint.

J Orthop Surg (Hong Kong) 2019 May-Aug;27(2):2309499019840771

Department of Orthopaedic Surgery, Nippon Medical School, Tokyo, Japan.

Purpose: We aimed to evaluate the clinical results using the pins and rubbers traction system (PRTS) as described by Suzuki et al. for unstable intra-articular fractures of the proximal interphalangeal (PIP) joint and to assess the efficacy and the indication of the technique of the PRTS.

Methods: Thirty-nine fingers in 39 patients (mean age 46. Read More

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http://dx.doi.org/10.1177/2309499019840771DOI Listing
April 2019
1 Read

Polyetheretherketone (PEEK) cages for anterior column reconstruction in pyogenic vertebral osteomyelitis.

J Orthop Surg (Hong Kong) 2019 May-Aug;27(2):2309499019842490

2 Department of Orthopaedic Surgery, University Medical Centre Ljubljana, Ljubljana, Slovenia.

The objective of study was to evaluate a case series of patients in whom polyetheretherketone (PEEK) cages were used for anterior column reconstruction in vertebral osteomyelitis. Fifteen patients underwent clinical and radiological evaluation with average follow-up of 26 months. Parameters assessed were time of surgery, blood loss, segmental kyphosis or lordosis angle, time to solid bony fusion, ambulatory status, and functional outcome. Read More

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http://dx.doi.org/10.1177/2309499019842490DOI Listing

Biofilm formation by Staphylococcus aureus clinical isolates correlates with the infection type.

Infect Dis (Lond) 2019 Apr 15:1-6. Epub 2019 Apr 15.

a Department of Rheumatology and Inflammation Research , Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.

Background: Biofilms are involved in many Staphylococcus aureus infections, but relation of biofilm formation and the infection types or the clinical outcomes remain unclear.

Methods: We measured biofilm formation, with a microtiter plate assay, of a collection of methicillin-sensitive clinical isolates from 159 invasive S. aureus infections, encompassing all cases occurring within a hospital catchment area during two years, and from additional 49 non-invasive skin infections from the same region. Read More

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http://dx.doi.org/10.1080/23744235.2019.1593499DOI Listing
April 2019
3 Reads

Mucormycotic osteomyelitis of maxilla following maxillofacial trauma: The disease of the diseased.

J Family Med Prim Care 2019 Feb;8(2):748-750

Department of Dentistry, Subdivisional Hospital, Ranchi, Jharkhand, India.

Mucormycosis is a rare opportunistic fungal infection with acute, aggressive, and invasive nature, seen in immunocompromised/debilitated patients, especially with diabetes mellitus. The key to successful therapy is the early diagnosis of signs and symptoms of the disease, correction of the underlying medical disorder(s), and aggressive medical and surgical intervention. The case presented here is mucormycotic osteomyelitis of the nasomaxillary-zygomatic complex following trauma in a middle-aged man. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_410_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436305PMC
February 2019
1 Read

Optic neuritis in an immunocompetent 40-year-old female due to fungal sphenoidal sinusitis.

GMS Ophthalmol Cases 2019 1;9:Doc06. Epub 2019 Mar 1.

Department of Glaucoma, Aravind Eye Hospital & Postgraduate Institute of Ophthalmology, Coimbatore, Tamilnadu, India.

Fungal shpenoidal sinusitis with osteomyelitis is rare in young immunocompetent patients. We present a case of a presumed fungal sphenoidal sinusitis presenting with second and sixth cranial nerve involvement which resolved well with systemic anti-fungal treatment. Read More

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http://dx.doi.org/10.3205/oc000095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436000PMC

Subacute Osteomyelitis of the Pediatric Talus: A First Report of Brodie's Abscess from Morganella morganii.

Case Rep Orthop 2019 11;2019:7108047. Epub 2019 Mar 11.

Department of Orthopaedic Surgery, Tripler Army Medical Center, Honolulu, HI, USA.

Brodie's abscess is a subacute form of osteomyelitis which generally occurs in the metaphysis of the femur and tibia in the pediatric population. Pathogens are most commonly Gram-positive bacteria, notably Staphylococcus and Streptococcus. In this article, we describe a young pediatric patient presenting with subacute ankle pain with a subsequent diagnosis of Brodie's abscess of the talus secondary to Morganella morganii. Read More

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http://dx.doi.org/10.1155/2019/7108047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432692PMC

[Treatment of distal humerus fracture with unexposed ulnar nerve medial elbow incision and anatomical locking compression plate].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Apr;33(4):440-444

Department of Orthopaedics, Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou Sichuan, 646000,

Objective: To investigate the feasibility and effectiveness of unexposed ulnar nerve medial elbow incision, open reduction and internal fixation of anatomical locking compression plate (LCP) for distal humerus fractures.

Methods: Fourteen patients with distal humerus fracture were treated between January 2014 and June 2017. There were 5 males and 9 females, aged 18-85 years (mean, 65. Read More

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http://www.rrsurg.com/article/10.7507/1002-1892.201808077
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http://dx.doi.org/10.7507/1002-1892.201808077DOI Listing
April 2019
4 Reads

Candida albicans skull base osteomyelitis due to malignant otitis externa: the role of echinocandin therapy associated with surgical debridement.

Enferm Infecc Microbiol Clin 2019 Apr 10. Epub 2019 Apr 10.

Servicio de Otorrinolaringología, Hospital Universitario 12 de Octubre, Madrid, España.

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http://dx.doi.org/10.1016/j.eimc.2019.02.006DOI Listing
April 2019
1 Read

Comparison of microbiological results obtained from per-wound bone biopsies versus transcutaneous bone biopsies in diabetic foot osteomyelitis: a prospective cohort study.

Eur J Clin Microbiol Infect Dis 2019 Apr 13. Epub 2019 Apr 13.

Department of Infectious and Tropical Diseases, CRIOAc, CHU Clermont-Ferrand, Université Clermont Auvergne UMR CNRS 6023 Laboratoire Microorganismes: Génome Environnement (LMGE), Clermont-Ferrand, France.

Transcutaneous bone biopsy (TCB) is the gold standard for taking microbiological specimens in diabetic foot osteomyelitis (DFO), but this technique is not widely used in diabetic foot care centers. We aimed to evaluate the reliability of per-wound bone biopsy (PWB) cultures by comparing them with concomitant TCB cultures obtained through healthy skin. This is a prospective monocentric study including patients seen in consultation for clinical and radiological diabetic foot osteomyelitis with positive probe-bone tests between April 2015 and May 2018. Read More

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http://dx.doi.org/10.1007/s10096-019-03547-6DOI Listing

MyD88 and IL-1R signaling drive antibacterial immunity and osteoclast-driven bone loss during Staphylococcus aureus osteomyelitis.

PLoS Pathog 2019 Apr 12;15(4):e1007744. Epub 2019 Apr 12.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.

Staphylococcus aureus is able to infect virtually all organ systems and is a frequently isolated etiologic agent of osteomyelitis, a common and debilitating invasive infection of bone. Treatment of osteomyelitis requires invasive surgical procedures and prolonged antibiotic therapy, yet is frequently unsuccessful due to extensive pathogen-induced bone damage that can limit antibiotic penetration and immune cell influx to the infectious focus. We previously established that S. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007744DOI Listing
April 2019
5 Reads

Dental pulp exposure, periapical inflammation and suppurative osteomyelitis of the jaws in juvenile Baltic grey seals (Halichoerus grypus grypus) from the late 19th century.

PLoS One 2019 12;14(4):e0215401. Epub 2019 Apr 12.

Department of Biology, University of Hildesheim, Hildesheim, Germany.

The systematic analysis of museum collections can provide important insights into the dental and skeletal pathology of wild mammals. Here we present a previously unreported type of dental defect and related skull pathology in five juvenile Baltic grey seals that had been collected in the course of a seal culling program along the Danish coast in 1889 and 1890. All five skulls exhibited openings into the pulp cavities at the crown tips of all (four animals) or two (one animal) canines as well as several incisors and (in one animal) also some anterior premolars. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215401PLOS
April 2019
1 Read

Systemic antibiotic treatment of chronic osteomyelitis in adults.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):258-270

Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy, Istituto di Clinica delle Malattie Infettive, Università Cattolica S. Cuore, Rome, Italy.

Chronic osteomyelitis is a difficult to treat infection of the bone, which requires a combined medical and surgical approach and often persists intermittently for years, with relapses and failures. The optimal type, route of administration, and duration of antibiotic treatment remain controversial, and the emergence of multi-drug resistant organisms poses major therapeutic challenges. Identification of the causative agent and subsequent targeted antibiotic treatment has a major impact on patients' outcome. Read More

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http://www.europeanreview.org/article/17500
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http://dx.doi.org/10.26355/eurrev_201904_17500DOI Listing
April 2019
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Clinical applications of Bioactive glass S53P4 in bone infections: a systematic review.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):240-251

Orthopedic Department, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.

Objective: Treatment of osteomyelitis, in of itself, is challenging but is further complicated by attendant bone infections. The management of bone infection, and bone rebuilding may be assisted by the use of bioactive glasses (BAGs) which have antimicrobial and osteo-stimulative proprieties. However, this clinical application and potential complications associated with BAGs (e. Read More

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http://www.europeanreview.org/article/17498
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http://dx.doi.org/10.26355/eurrev_201904_17498DOI Listing
April 2019
1 Read

Masquelet technique and osteomyelitis: innovations and literature review.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):210-216

Department of Orthopaedics and Traumatology, Institute of Scientific Research, Children's Hospital Bambino Gesù, Rome, Italy.

Objective: Wide diaphyseal bone defects, above all those infected, encounter into Masquelet technique a suitable treatment. The two-step procedure allows the surgeon to eliminate the infected tissues and then to promote new bone formation. We analyzed the literature about the use of the induced membrane technique in osteomyelitis and the innovations recently suggested. Read More

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http://www.europeanreview.org/article/17495
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http://dx.doi.org/10.26355/eurrev_201904_17495DOI Listing
April 2019
1 Read

Spondylodiscitis: is really all well defined?

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):201-209

Infectious Diseases Unit, Department of Medical and Surgical Sciences, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

The term spondylodiscitis describes the infection of both the intervertebral disc space and the adjacent vertebrae. Pyogenic Vertebral Osteomyelitis (PVO) is more common in older patients (mean age 59-69 years) with a male preponderance (52-69%). Recent studies reported an alarming increase of incidence over the last 20 years, due to the increase of diagnostic sensibility, the increase of the average lifetime and to the consequent association of chronic disabling pathologies, of immunosuppression, of surgical or invasive procedure. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17494DOI Listing

Managing of musculoskeletal infections in children.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):179-186

Department of Orthopaedics and Traumatology, Institute of Scientific Research, Children's Hospital Bambino Gesù, Rome, Italy.

Objective: Epidemiological features of musculoskeletal infections are in continuous evolution. The incidence of emerging causative pathogen is arising. Nevertheless, up to 50% of osteoarticular infections shows negative cultures. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17488DOI Listing
April 2019
1 Read

Acute osteomyelitis and septic arthritis in children: a systematic review of systematic reviews.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):145-158

Orthopaedics and Traumatology, Polytechnic University of Marche, Ancona, Italy.

Objective: Septic arthritis and osteomyelitis are rare in children, but they are difficult to treat and are associated with a high rate of sequelae. This paper addresses the main clinical issues related to septic arthritis and osteomyelitis by means of a systematic review of systematic reviews.

Materials And Methods: The major electronic databases were searched for systematic reviews/meta-analyses septic arthritis and osteomyelitis. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17484DOI Listing
April 2019
2 Reads

Diabetic foot infections: a comprehensive overview.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):26-37

Diabetes Care Unit, Endocrinology, University Hospital "A. Gemelli", Catholic University of the Sacred Heart, Rome, Italy.

Diabetic foot ulcers (DFUs), a micro-vascular complication, are associated with a substantial increase in morbidity and mortality. DFUs are a complicated mixture of neuropathy, peripheral arterial diseases, foot deformities, and infections. Foot infections are frequent and potentially devastating complications. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17471DOI Listing
April 2019
1 Read

Cervical spondylodiscitis mimicking Pott's disease: a case report.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):1-5

Department of Medical and Surgical Sciences, University Magna Græcia, Catanzaro, Italy.

Introduction: The leading cause of pyogenic vertebral osteomyelitis is Staphylococcus aureus, and its incidence is rising, particularly in the elderly. We report an unusual case of cervical spondylodiscitis and epidural abscess mimicking Pott's disease.

Case Report: A 67-year-old man was admitted to our institution with a 15-day history of neck pain radiating to the head, shoulders and left arm that was associated with weakness and paresthesia. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17467DOI Listing
April 2019
1 Read

Locked intramedullary nailing using the sign nailing device.

Authors:
I C Nwagbara

Niger J Clin Pract 2019 Apr;22(4):485-491

Orthopaedic Surgery Unit, Imo State University Teaching Hospital, Orlu, Imo State, Nigeria.

Objective: Locked intramedullary nailing is the treatment of choice not only in diaphyseal fractures of long bone but also in most metaphyseal and periarticular fractures. In this study, we set out to present our experience with the Surgical Implant Generation Network (SIGN)] technique of locked intramedullary nailing in long bones that do not require the use of image intensifier, fracture table, and power reamers.

Patients And Methods: This was a hospital-based prospective descriptive study involving 54 consecutive patients seen over a 2-year period. Read More

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http://dx.doi.org/10.4103/njcp.njcp_245_18DOI Listing

A rare case of osteomyelitis of the clavicle in a child due to Group A streptococcal infection.

BMJ Case Rep 2019 Apr 11;12(4). Epub 2019 Apr 11.

Paediatrics, University Hospitals of Leicester, Leicester, UK.

Acute osteomyelitis of the clavicle is rare in the paediatric age group. We treated a 5-year-old boy who presented initially with fever and left shoulder pain, and subsequently developed swelling in the region of the left clavicle. Group A (GAS) was isolated in blood culture. Read More

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http://dx.doi.org/10.1136/bcr-2018-227090DOI Listing
April 2019
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Sternal osteomyelitis by in an immunocompetent patient after open heart surgery.

Ann Card Anaesth 2019 Apr-Jun;22(2):221-224

Department of Internal Medicine, Maimonides Medical Center, New York City, USA.

Gordonia is a catalase-positive, aerobic, nocardioform, Gram-positive staining actinomycete that also shows weak acid-fast staining. Several Gordonia species are commonly found in the soil. The bacterium has been isolated from the saliva of domesticated/wild dogs as well. Read More

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http://dx.doi.org/10.4103/aca.ACA_125_18DOI Listing
April 2019
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Small round cell lesions of the bone: Diagnostic approach, differential diagnoses and impact on treatment.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):199-205

Department of Pathology, Regional Cancer Centre, Thiruvananthpuram, Kerala, India.

Small round cell lesions of the bone encompass a heterogeneous group of tumors and tumor-like lesions, including Ewing sarcoma, small cell osteosarcoma, mesenchymal chondrosarcoma, neuroblastoma, non-Hodgkin's lymphoma (NHL), "Ewing-like" undifferentiated round cell sarcomas, metastasizing small cell carcinoma, along with plasma cell dyscrasia and Langerhan's cell histiocytosis. At the same time, there are tumor mimics, for example, chronic osteomyelitis, which has overlapping radiologic features with Ewing sarcoma and a primary intraosseous NHL. An exact diagnosis necessitates integration of clinical, radiologic, pathologic, and ancillary test results, including immunohistochemical and molecular results. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_675_18DOI Listing
April 2019
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Predicting Periarticular Infection in Children With Septic Arthritis of the Hip: Regionally Derived Criteria May Not Apply to All Populations.

J Pediatr Orthop 2019 May/Jun;39(5):268-274

The Children's Hospital of Philadelphia, Philadelphia, PA.

Background: The management of septic arthritis of the hip in children can be complicated by the presence of additional coexisting periarticular infections (PAIs). Criteria predicting the presence of PAI have recently been proposed by Rosenfeld and colleagues with the goal of using magnetic resonance imaging (MRI) efficiently in the workup of septic arthritis. The purpose of this study was to determine the applicability of recently published predictive criteria for PAI (developed in the Southwestern United States using a variety of joints) to septic arthritis of the hip treated at a large Northeastern tertiary care center. Read More

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http://dx.doi.org/10.1097/BPO.0000000000000934DOI Listing
April 2019
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Potts puffy tumour: a rare but important diagnosis.

J Surg Case Rep 2019 Apr 3;2019(4):rjz099. Epub 2019 Apr 3.

Department of ENT, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Potts puffy tumour (PPT) is a subperiosteal abscess arising from frontal bone osteomyelitis. We present a case of a 75-year-old lady with headache and a forehead swelling who was initially treated for sinusitis and giant cell arteritis in a primary care setting, but failed to improve. Following clinical deterioration and further investigation, CT appearances were consistent with a diagnosis of PPT and an extra-axial collection. Read More

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https://academic.oup.com/jscr/article/doi/10.1093/jscr/rjz09
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http://dx.doi.org/10.1093/jscr/rjz099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446532PMC
April 2019
4 Reads

Rare case of a 3-year-old with skull base osteomyelitis: lessons to be learnt.

BMJ Case Rep 2019 Apr 8;12(4). Epub 2019 Apr 8.

Ear, Nose and Throat Surgery, Lister Hospital, Stevenage, UK.

Skull base osteomyelitis (SBO) is a serious and rare condition most commonly seen in elderly diabetic or immunocompromised patients as a complication of otitis externa. We present the case of a previously healthy 3-year-old girl who presented to the paediatric emergency department with vomiting, fever, lethargy, headache and left-sided facial nerve palsy. The initial CT head revealed left-sided otitis media with otomastoiditis and she was managed with intravenous antibiotics and myringotomy with grommet insertion with initial improvement. Read More

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http://dx.doi.org/10.1136/bcr-2018-228026DOI Listing
April 2019
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Osteomyelitis Caused by Carbapenemase-Producing Klebsiella Pneumoniae: A Diagnosis to Consider in Patients with Hematologic Malignancies and Stem Cell Transplant Recipients.

Am J Case Rep 2019 Apr 9;20:482-488. Epub 2019 Apr 9.

Department of Hematology and Bone Marrow Transplantation, Hospital de Santa Maria, CHLN - EPE, Lisboa, Portugal.

BACKGROUND Osteomyelitis (OM) due to carbapenemase-producing Klebsiella pneumoniae (CPKp) is a very rare but severe condition, particularly among patients with hematologic malignancies and stem cell transplant recipients, who are especially at risk of developing nosocomial infections caused by this bacterium. CASE REPORT We describe 2 cases of acute and chronic OM by CPKp in adults with hematologic disorders. Patient 1, with acute lymphoblastic leukemia, developed bacteremia due to multidrug CPKp after induction chemotherapy. Read More

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http://dx.doi.org/10.12659/AJCR.909965DOI Listing
April 2019
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Orthopedics in Reptiles and Amphibians.

Vet Clin North Am Exot Anim Pract 2019 May;22(2):285-300

Department of Veterinary Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, 2065 West Farm Road, Stillwater, OK 74078, USA.

Musculoskeletal disorders are a common cause for presentation of reptiles and amphibians to the veterinarian. A clinical approach to orthopedic cases starts with a thorough history and review of husbandry, and identification of any underlying or concomitant disease. Medical management is indicated for pathologic fractures. Read More

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http://dx.doi.org/10.1016/j.cvex.2019.01.009DOI Listing
May 2019
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Orthopedic Diagnostic Imaging in Exotic Pets.

Vet Clin North Am Exot Anim Pract 2019 May;22(2):149-173

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, 2015 Southwest 16th Avenue, PO Box 100116, Gainesville, FL 32610-0116, USA. Electronic address:

Orthopedic diseases are a common problem in exotic pets. Diagnostic imaging modalities are more accessible and available in exotic animal veterinary medicine; the higher standards of care of the veterinary profession have progressed toward an increased offer of advanced imaging modalities. The literature on the use of diagnostic imaging modalities in orthopedic disease of exotic pets is scarce. Read More

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http://dx.doi.org/10.1016/j.cvex.2019.01.003DOI Listing

Microbiological Diagnosis of Skeletal System Infections in Children.

Authors:
Pablo Yagupsky

Curr Pediatr Rev 2019 Apr 8. Epub 2019 Apr 8.

Clinical Microbiology Laboratory, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva 84101. Israel.

Background: If not timely diagnosed and adequately treated, skeletal system infections in children may result in severe and permanent disability. Prompt identification of the etiology of the disease and determination of its antibiotic susceptibility is crucial for the successful management of septic arthritis, osteomyelitis, and spondylodiscitis. However, the bacteriological diagnosis of these infections has been traditionally limited by the low yield of conventional cultures and, on average, one-third of cases of pediatric joint and bone infections remained unconfirmed. Read More

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http://dx.doi.org/10.2174/1573396315666190408114653DOI Listing
April 2019
2 Reads

Incidence and mortality of osteomielitis in Spain according to the basic minimum data set.

Med Clin (Barc) 2019 Apr 4. Epub 2019 Apr 4.

Facultad de Medicina, Universidad Católica de Valencia, Valencia, España.

Background And Objectives: To understand the incidence and mortality of patients hospitalised for osteomyelitis in Spain.

Material And Method: An observational study of the population admitted to Spanish hospitals with a primary diagnosis of osteomyelitis, according to the minimum basic data set for hospital discharge (MBDS), between 1997 - 2014 (29 290 cases) was carried out.

Results: The incidence was 3. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00257753193013
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http://dx.doi.org/10.1016/j.medcli.2019.02.004DOI Listing
April 2019
5 Reads

Risk Factors for Amputation in Diabetic Foot Infections: A Meta-Analysis.

Diabetes Metab Res Rev 2019 Apr 5:e3165. Epub 2019 Apr 5.

Department of Biostatistics, Izmir Katip Celebi University School of Medicine, Izmir, Turkey.

Aims: Knowledge of risk factors is crucial to develop management and treatment protocols for the prevention of lower extremity amputation for patients with diabetic foot infections (DFI).

Materials And Methods: We searched the research literature for studies reporting risk factors for lower extremity amputation in patients with DFI. The main outcome variables included both minor and major amputations. Read More

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http://dx.doi.org/10.1002/dmrr.3165DOI Listing
April 2019
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