32,153 results match your criteria Osteomyelitis

Pediatric rib pathologies: clinicoimaging scenarios and approach to diagnosis.

Pediatr Radiol 2021 Jun 12. Epub 2021 Jun 12.

Radiology Department, Seattle Children's Hospital, University of Washington Medical Center, 4800 Sand Point Way NE, Seattle, WA, 98105, USA.

Pathologies involving the ribs are diverse in nature, including entities specific to the pediatric population as well as shared pathologies with adults. These can be either localized within or adjacent to the rib, but may also cause rib alteration as a component of a systemic process. To better understand these disorders, we discuss several common rib pathologies in the context of their clinical presentation and pertinent imaging findings. Read More

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Bioactive glass S53P4 to fill-up large cavitary bone defect after acute and chronic osteomyelitis treated with antibiotic-loaded cement beads: A prospective case series with a minimum 2-year follow-up.

Injury 2021 Jun 1. Epub 2021 Jun 1.

Trauma Service, Instituto de Ortopedia e Traumatologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, SP, Brazil.

Introduction: Bioactive glass S53P4 (BAG-S53P4) has been used in the treatment of osteomyelitis with excellent results. The aim of this study was to evaluate the clinical and radiographic results of patients treated with use of antibiotic-loaded cement beads, followed by bone defects filling using bioglass.

Methods: We treated a prospective series of patients presenting with acute or chronic osteomyelitis of a long bone of the upper or lower limb. Read More

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Use of a Transarticular Calcaneo-Tibial Locking Plate for Temporary Immobilization of the Tarsocrural Joint following Surgical Repair of Common Calcaneal Tendon Rupture in Eight Dogs.

Vet Comp Orthop Traumatol 2021 Jun 11. Epub 2021 Jun 11.

Dipartimento di Scienze Veterinarie, Università di Torino, Grugliasco (To), Italy.

Objective:  The purpose of this clinical communication is to report the management of common calcaneal tendon rupture in dogs using a transarticular calcaneo-tibial locking plate as a method of temporary immobilization of the tarsocrural joint to support primary repair of the common calcaneal tendon.

Study Design:  Dogs presented with partial or complete common calcaneal tendon rupture treated with primary tendon repair supported by the transarticular calcaneo-tibial locking plate technique from July 2016 to December 2019 were included. The tarsus was placed at a standing angle of 150 degrees and the pre-contoured Fixin locking 'L' or 'T' plate was medially applied with two locking screws inserted in the calcaneus and two screws inserted in the distal tibia. Read More

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The diagnostic utility of size and apparent diffusion coefficient values for cervical lymph nodes in patients with osteomyelitis of the jaw bone.

Oral Radiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiology, Nihon University School of Dentistry At Matsudo, 2-870-1 Sakaecho-Nishi, Matsudo, Chiba, 271-8587, Japan.

Purpose: The purpose of this study was to (1) clarify the size and apparent diffusion coefficient (ADC) value of lymph nodes (LN) in each state in their quantitative evaluation diffusion-weighted imaging, and (2) to determine the diagnostic utility of size and ADC values in the quantitative evaluation of LNs using diffusion-weighted imaging.

Methods: This was a retrospective cohort study at our hospital conducted between April 2017 and March 2019. A total of 50 patients (20 men, 30 women) with 118 LNs, aged 34-90 years (mean age 61. Read More

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Performance of Computed Tomography-Guided Spine Biopsy for the Diagnosis of Malignancy and Infection.

Oper Neurosurg (Hagerstown) 2021 Jun 10. Epub 2021 Jun 10.

Neurosurgery Department, Queen's Hospital, Barking, Havering and Redbridge University Hospitals NHS Trust, London, UK.

Background: Computed tomography (CT)-guided percutaneous biopsies are used to guide treatment in vertebral osteomyelitis and spinal malignancy, but the efficacy of this study remains unclear.

Objective: To investigate the performance of CT-guided spinal biopsy, and factors that may influence its success.

Methods: Retrospective study of all consecutive patients who underwent a CT-guided spine biopsy at a UK teaching hospital between April 2012 and February 2019. Read More

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Surgical Management of Thoracolumbar Spondylodiscitis in End-Stage Renal Disease.

Indian J Orthop 2021 May 6;55(Suppl 1):176-181. Epub 2020 May 6.

Department of Orthopaedics, M S Ramaiah Medical College, Bangalore, India.

Background: In recent times due to the advancement of haemodialysis techniques, there is increase in the life span of the patients with end-stage renal disease, which tends to increase the risk of complications of bacteraemia due to skin penetration for blood access and leading to propensity for more skeletal and spinal complications. Hence, early diagnosis of spine infection and early initiation of appropriate therapy are important in ensuring successful treatment and preventing further morbidity.

Materials And Methods: The study included 22 males and 12 females who were known case of end-stage renal disease undergoing haemodialysis therapy and diagnosed with spondylodiscitis based on the clinical and radiological signs. Read More

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Clinical Results after Arthroscopic Treatment of Septic Shoulder with Proximal Bone Involvement.

Indian J Orthop 2021 May 6;55(Suppl 1):167-175. Epub 2020 Apr 6.

Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351 South Korea.

Background: If osteomyelitis is confined to the proximal humerus, arthroscopic debridement with multiple punctures at the infected bone might be sufficient to eradicate the septic shoulder with bone involvement.

Materials And Methods: From 2005 to 2017, 15 patients received arthroscopic debridement with multiple punctures. We included patients with septic shoulder arthritis with proximal bone involvement and excluded patients with glenohumeral joint destruction or extension of bone involvement to the diaphysis of the humerus. Read More

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A Rare Case of Invasive Keratinizing Squamous Cell Carcinoma of the Foot.

Int Med Case Rep J 2021 4;14:381-384. Epub 2021 Jun 4.

Department of Infectious Diseases, Saint Vincent Hospital, Worcester, MA, 01608, USA.

Lower extremity soft-tissue lesions are frequently encountered in clinical practice. Cellulitis, osteomyelitis, and diabetic foot ulcerations remain the top differentials. The acuity of illness, imaging studies, and deep wound cultures are helpful in most cases. Read More

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What is the burden of osteomyelitis in Germany? An analysis of inpatient data from 2008 through 2018.

BMC Infect Dis 2021 Jun 10;21(1):550. Epub 2021 Jun 10.

Department for Trauma Surgery, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.

Background: The epidemiology of osteomyelitis in Germany is unknown, which makes it difficult to estimate future demands. Therefore, we aimed to analyse how the numbers of cases have developed over the last decade as a function of osteomyelitis subtype, age group, gender, and anatomical localization.

Methods: Osteomyelitis rates were quantified based on annual ICD-10 diagnosis codes from German medical institutions between 2008 through 2018, provided by the Federal Statistical Office of Germany (Destatis). Read More

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Are Oral Antibiotics an Effective Alternative to Intravenous Antibiotics in Treatment of Osteomyelitis of The Jaw?

J Oral Maxillofac Surg 2021 Apr 22. Epub 2021 Apr 22.

Clinical Associate Professor, Program Director, Chief of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, University of Washington, Harborview Medical Center, Seattle, WA. Electronic address:

Purpose: To review treatment of osteomyelitis of the jaw (OMJ) and determine whether antibiotic route and/or length of administration impacts resolution of infection postsurgically.

Methods: The investigators designed a retrospective cohort study enrolling a sample of patients treated at Harborview Medical Center from January 1st 2009 to December 31st 2019. The primary predictor variable was antibiotic administration route: oral (PO) only, intravenous (IV) only, IV transitioned to PO (IV + PO), or none. Read More

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Vascularized fibula flap in the management of segmental bone loss following osteomyelitis in children at a Ugandan hospital.

J Bone Jt Infect 2021 25;6(6):179-187. Epub 2021 May 25.

Trauma and Orthopedic Department, Bristol Royal Infirmary, Bristol, United Kingdom.

: Hematogenous osteomyelitis is commonly observed in the pediatric population across sub-Saharan Africa. This retrospective case series was designed to evaluate the complications and outcomes of treatment using a vascularized fibula flap (VFF) to fill segmental bone defects secondary to osteomyelitis in children in a low-resource setting in CoRSU Rehabilitation Hospital, Uganda. : Clinical notes and radiographs of children with a diagnosis of osteomyelitis that subsequently underwent a VFF procedure between October 2013 and December 2017 were reviewed. Read More

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Costal osteomyelitis due to in a 10-year-old girl.

J Bone Jt Infect 2021 20;6(6):171-178. Epub 2021 May 20.

Infectious Diseases Department, Dijon University Hospital, Dijon, France.

is the bacterial agent responsible for cat scratch disease. This infection is frequently the cause of localized lymphadenitis in children. It is also sometimes responsible for endocarditis, encephalitis, hepatic peliosis and in rare cases osteomyelitis. Read More

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Talaromycosis marneffei of the Cervical Spine: An Unusual Infection.

J Am Acad Orthop Surg Glob Res Rev 2021 06 9;5(6). Epub 2021 Jun 9.

From the Department of Orthopaedics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Talaromyces marneffei infection (TMI) causing vertebral osteomyelitis of the cervical spine is extremely rare. TMI in an HIV-uninfected patient is also unusual. This report presents the successful treatment of an HIV-uninfected TMI patient who underwent C6 and T1 vertebrectomies, bone grafting, and anterior cervical plating accompanied by antifungal therapy. Read More

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Osteomyelitis, diabetic foot ulcers and the role of the community nurse.

Melanie Lumbers

Br J Community Nurs 2021 Jun;26(Sup6):S6-S9

Freelance Tissue Viability Nurse and Health Visitor, Bedfordshire.

Community nurses face numerous challenges in both diagnosing and effectively treating their patients. The diabetic patient has complex needs requiring a holistic approach. With a reported increase in diabetic patients, and a possible decline in some routine screening following Covid-19 pandemic, complications in diabetic patients are likely to rise. Read More

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Bovine Hydroxyapatite-Based Bone Scaffold with Gentamicin Accelerates Vascularization and Remodeling of Bone Defect.

Int J Biomater 2021 5;2021:5560891. Epub 2021 May 5.

Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.

Osteomyelitis is an infectious disease which is also a major complication of bone defects. This study aims to determine the effect of bovine hydroxyapatite-gelatin-based bone implants with gentamicin as an antibiotic (BHA-GEL-GEN implant) on the regeneration of bone defects . The BHA-GEL-GEN and BHA-GEL implants were made by direct compression. Read More

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Neutropenia, Thrombocytopenia, and Eosinophilia: An Unusual Triad in a Patient on Long-Term Vancomycin Therapy.

Am J Case Rep 2021 Jun 8;22:e931647. Epub 2021 Jun 8.

School of Medicine, Saint Louis University, Saint Louis, MO, USA.

BACKGROUND Vancomycin is an antibiotic commonly used for management of severe gram-positive infections. It is infrequently associated with hematologic adverse effects, ranging from isolated thrombocytopenia or neutropenia to pancytopenia. Although the mechanism is poorly understood, it is considered an immune-mediated phenomenon. Read More

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Diffuse Recalcitrant Osteomyelitis and Joint Septicemia Because of Bowel Perforation Secondary to Gunshot Injury: A Case Report.

JBJS Case Connect 2021 06 8;11(2). Epub 2021 Jun 8.

Department of Orthopaedic Surgery, Loma Linda University Health, Loma Linda, California.

Case: A previously healthy 22-year-old man was brought into the emergency department after sustaining a low-velocity, civilian gunshot wound to the abdomen that perforated the bowel. Over the next 300 days, he would be admitted and discharged multiple times, requiring a total of 48 debridements, 23 different antimicrobials in 81 unique combinations, and had 18 different microbes cultured from various sites in bone, joint, and blood. Multiorganism bacteremia and fungemia culminated in above-knee amputation because of progression of infection, all in a nonimmunocompromised host. Read More

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Immune Checkpoint Inhibition in Marjolin Ulcer: A Case Series.

J Immunother 2021 Jul-Aug 01;44(6):234-238

Division of Hematology/Oncology, Departments of Medicine.

Immunotherapy has revolutionized the treatment of advanced cutaneous squamous cell carcinoma. However, the role of immune checkpoint inhibitors for the treatment of Marjolin ulcer (MU), a rare cutaneous malignancy that arises from previously traumatized and chronically inflamed skin, is not well defined. Thus, efficacy and clinical response to immunotherapy in patients with MU requires further investigation. Read More

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October 2020

Contemporary clinical isolates of from pediatric osteomyelitis patients display unique characteristics in a mouse model of hematogenous osteomyelitis.

Infect Immun 2021 Jun 7:IAI0018021. Epub 2021 Jun 7.

Division of Bone & Mineral Diseases, Musculoskeletal Research Center, Washington University School of Medicine, Saint Louis, MO, USA.

Osteomyelitis can result from the direct inoculation of pathogens into bone during injury or surgery, or from spread via the bloodstream, a condition called hematogenous osteomyelitis (HOM). HOM disproportionally affects children, and more than half of cases are caused by . Laboratory models of osteomyelitis mostly utilize direct injection of bacteria into the bone or the implantation of foreign material, and therefore do not directly interrogate the pathogenesis of pediatric hematogenous osteomyelitis. Read More

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Zinc alloy-based bone internal fixation screw with antibacterial and anti-osteolytic properties.

Bioact Mater 2021 Dec 18;6(12):4607-4624. Epub 2021 May 18.

Department of Orthopedics, Shanghai Key Laboratory of Orthopedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

There is no targeted effective treatment for patients undergoing internal fixation surgery/two-stage total joint revision surgery with a high risk of postoperative infection and osteolysis, while the rate of reoperation due to infection and osteolysis remains high. In this study, we report a pioneering application of implants made of biodegradable Zn-Ag alloy with active antibacterial and anti-osteolytic properties in three classical animal models, illustrating antibacterial, anti-osteolysis, and internal fixation for fractures. The antibacterial activity of the Zn-2Ag alloy was verified in a rat femur osteomyelitis prevention model, while the anti-osteolytic properties were evaluated using a mouse cranial osteolysis model. Read More

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December 2021

Beware of covert enemies: malignant otitis externa with base of the skull osteomyelitis, a case report and review of literature.

IDCases 2021 18;25:e01163. Epub 2021 May 18.

Department of Infectious Diseases, Communicable Diseases Centre, Hamad Medical Corporation, Qatar.

Background: Malignant otitis externa (MOE) is a serious infection of the external auditory canal that is frequently associated with skull base osteomyelitis (SBO) as well as secondary neurological sequelae. Patients with poorly controlled diabetes mellitus or immunosuppression are at increased risk of developing such critical infection for multiple local and systemic factors. While most cases are secondary to bacterial infections particularly, fungal infections are also occasionally encountered, often associated with delayed diagnosis and high morbidity and mortality. Read More

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Operative Treatment of Adult Pyogenic Spondylodiscitis: A Retrospective Study of 32 Cases.

Cureus 2021 May 3;13(5):e14820. Epub 2021 May 3.

Orthopaedic Department, Papageorgiou General Hospital of Thessaloniki, Thessaloniki, GRC.

Background Spondylodiscitis is a potentially life-threatening infection that imposes a significant financial burden on healthcare systems. Current reports suggest an increase in the incidence of spondylodiscitis, which could be attributed to the aging population and the growing rates of drug abuse. This study aims to evaluate the safety and effectiveness of surgical treatment of spondylodiscitis. Read More

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Combination of aztreonam, ceftazidime-avibactam and amikacin in the treatment of VIM-1 Pseudomonas aeruginosa ST235 osteomyelitis.

Int J Infect Dis 2021 Jun 3. Epub 2021 Jun 3.

Infectious Diseases Section, Department of Medicine and Surgery, University of Insubria, Varese, Italy.

We describe a challenging case of a patient with MBL-producing Pseudomonas aeruginosa sternal osteomyelitis following aortic valve replacement with biological prosthesis. The strain exhibited a multidrug-resistance phenotype carrying the bla1 gene and belonged to the high-risk clone sequence type ST235. The patient was successfully treated with surgical debridement plus antibiotic therapy with ceftazidime/avibactam, aztreonam, and amikacin. Read More

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Clinical characteristics of pyogenic vertebral osteomyelitis and factors associated with inadequate treatment response.

Int J Infect Dis 2021 Jun 3. Epub 2021 Jun 3.

Department of Infectious Diseases, Heart Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Objectives: Pyogenic vertebral osteomyelitis (PVO) is associated with a high burden of disease. We aimed to describe characteristics at presentation of PVO, risk of inadequate treatment response (ITR), relapse and death, and to determine risk factors for ITR.

Methods: Patients with an ICD-10 discharge code for PVO admitted to a major Danish university hospital between November 2016 to April 2019 were included. Read More

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Pneumococcal osteomyelitis of the rib in a vaccinated infant: An exceptional case.

Enferm Infecc Microbiol Clin (Engl Ed) 2021 Jun-Jul;39(6):311-312. Epub 2021 May 3.

Departamento de Infectología Pediátrica, Servicio de Pediatría, Hospital Universitario de Getafe, Getafe, Madrid, Spain.

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Single-Atom Catalysis for Efficient Sonodynamic Therapy of Methicillin-Resistant -Infected Osteomyelitis.

ACS Nano 2021 Jun 4. Epub 2021 Jun 4.

School of Materials Science & Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China.

Osteomyelitis, as a severe bone disease caused by bacterial infection, can result in lifelong disability or fatal sepsis. Considering that the infection is stubborn and deep-sited in bone tissue, and rapid treatments for osteomyelitis remain a significant challenge. Herein, we prepare an ultrasound (US)-activated single-atom catalyst that consists of a Au nanorod (NRs)-actuated single-atom-doped porphyrin metal-organic framework ([email protected]) and red cell membrane (RBC), which can efficiently treat methicillin-resistant (MRSA)-infected osteomyelitis under US. Read More

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A retrospective cohort study comparing clinical outcomes and healthcare resource utilisation in patients undergoing surgery for osteomyelitis in England: a case for reorganising orthopaedic infection services.

J Bone Jt Infect 2021 28;6(5):151-163. Epub 2021 Apr 28.

Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 7HE, UK.

: An investigation of the impact of a multidisciplinary bone infection unit (BIU) undertaking osteomyelitis surgery with a single-stage protocol on clinical outcomes and healthcare utilisation compared to national outcomes in England. : A tertiary referral multidisciplinary BIU was compared to the rest of England (ROE) and a subset of the 10 next busiest centres based on osteomyelitis treatment episode volume (Top Ten), using the Hospital Episodes Statistics database (HES). A total of 25 006 patients undergoing osteomyelitis surgery between April 2013 and March 2017 were included. Read More

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Osteomyelitis in heterotopic ossification in a patient with congenital gigantism of the leg.

J Bone Jt Infect 2021 16;6(5):141-145. Epub 2021 Apr 16.

Department of Trauma and Orthopaedics, Mater Dei Hospital, Msida, Malta.

This paper presents the first report of osteomyelitis in heterotopic ossification in a patient with macrodystrophia lipomatosa. Careful review of magnetic resonance imaging allowed correct diagnosis and design of a limited surgical excision. Osteomyelitis should be considered in the differential diagnosis of pain and discharge when heterotopic ossification is present. Read More

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Fluorescent tetracycline bone labeling as an intraoperative tool to debride necrotic bone during septic hip revision: a preliminary case series.

J Bone Jt Infect 2021 27;6(4):85-90. Epub 2021 Jan 27.

Department of Infectious Diseases, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain.

A plausible cause of persistent infection after septic hip revision may be the presence of nonviable osteomyelitic bone. Since surgical excision of these necrotic fragments is often challenging, the use of fluorescent tetracycline bone labeling (FTBL) as an intraoperative tool may pose an additional assessment aid to provide a visual index of surgical debridement. : We present a single-center study performed in a university hospital from January 2018 to June 2020, in which all consecutive cases of chronic hip periprosthetic joint infection (PJI) undergoing revision using FTBL were retrospectively reviewed. Read More

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January 2021

Bioactive glass S53P4 vs. autologous bone graft for filling defects in patients with chronic osteomyelitis and infected non-unions - a single center experience.

J Bone Jt Infect 2021 12;6(4):73-83. Epub 2021 Jan 12.

Department of Orthopedic and Trauma Surgery, BG Klinikum Duisburg, University of Duisburg-Essen, 47249 Duisburg, Germany.

: The goals of osteomyelitis therapy are successful control of infection and reconstruction of the bone. The gold standard for filling defects is the autologous bone graft. Bioactive glass S53P4 is an inorganic bone substitute. Read More

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January 2021