29,350 results match your criteria Osteomyelitis


The use of chimeric musculocutaneous posterior interosseous artery flaps for treatment of osteomyelitis and soft tissue defect in hand.

Microsurgery 2019 Feb 19. Epub 2019 Feb 19.

Swissparc AG, Hand Surgery Service, Zürich, Switzerland.

Introduction: There is growing evidence of the superior ability of muscular tissue to clear bacterial bone infection. Unfortunately, in the hand, there are almost no small local muscular flaps, and muscular transfers to the hand are mainly microsurgical free transfers. In this report, we present the results of the use of a chimeric posterior interosseous flap including part(s) of the forearm muscles to treat osteomyelitis and soft tissue defect of hand from a series of patients. Read More

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http://dx.doi.org/10.1002/micr.30434DOI Listing
February 2019

Percutaneous image-guided bone biopsy of osteomyelitis in the foot and pelvis has a low impact on guiding antibiotics management: a retrospective analysis of 60 bone biopsies.

Skeletal Radiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Radiology and Medical Imaging, University of Virginia Health System, 1215 Lee Street, PO Box 800170, Charlottesville, VA, 22908, USA.

Objective: Image-guided percutaneous bone biopsy may be requested by clinicians to guide antibiotics management decisions in patients with extremity osteomyelitis. Much of the clinical literature describes a high rate of bone biopsy culture positivity in patients with osteomyelitis, but anecdotally biopsy is felt to be fairly low yield in many musculoskeletal radiology practices. The objective of the study is to determine the culture positivity rate and clinical utility of bone biopsy in guiding the management of patients with osteomyelitis. Read More

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http://dx.doi.org/10.1007/s00256-019-3152-4DOI Listing
February 2019

Impact of Fluoroscopically Guided Bone Biopsy on Antibiotic Management of Osteomyelitis in the Lower Extremity.

J Surg Orthop Adv 2018 ;27(4):277-280

Wake Forest Baptist Health, Winston-Salem, North Carolina; e-mail:

This study evaluated the impact of fluoroscopically guided percutaneous bone biopsy on altering antibiotic regimens in lower extremity osteomyelitis. Eighty-eight patients who received fluoroscopically guided bone biopsies were identified. There was bacterial growth in 28% of bone biopsies overall. Read More

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January 2018

Mandibular blastomycosis: A case report and review of the literature.

Germs 2018 Dec 3;8(4):207-213. Epub 2018 Dec 3.

BDS, MB ChB, FRCS, FACS, Division of Oral and Maxillofacial Surgery, Loyola University Medical Center, 2160 S. 1st Ave., Maywood, IL 60153, USA.

Introduction: Blastomycosis is an endemic mycosis in the United States known to primarily cause pneumonia. However, dissemination to different organs including the musculoskeletal system has been described.

Case Report: We report a case of mandibular blastomycosis in a healthy patient with no evidence of lung involvement. Read More

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http://dx.doi.org/10.18683/germs.2018.1148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363401PMC
December 2018

Role of fluoroethyl tyrosine positron emission tomography-computed tomography scan in differentiating ewing's sarcoma from osteomyelitis.

World J Nucl Med 2019 Jan-Mar;18(1):77-80

Department of Nuclear Medicine and PET Imaging, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India.

Ewing's sarcoma is a kind of undifferentiated reticulocytic sarcoma, which was first reported in 1921 by James Ewing. It is difficult to differentiate Ewing's sarcoma from osteomyelitis on computed tomography (CT) and X-ray and hence cytological confirmation is needed. Fluorodeoxy glucose being a nonspecific tracer cannot differentiate between malignant and inflammatory lesions. Read More

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http://dx.doi.org/10.4103/wjnm.WJNM_23_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357705PMC
February 2019

CLINICAL EVALUATION OF PATIENTS WITH VANCOMYCIN SPACER RETAINED FOR MORE THAN 12 MONTHS.

Acta Ortop Bras 2019 Jan-Feb;27(1):55-58

Universidade de São Paulo, Faculdade de Medicina, Instituto de Ortopedia e Traumatologia, São Paulo, São Paulo, Brazil.

Objective: There is no consensus in the literature regarding the time taken to remove antibiotic spacers in the treatment of bone infections. The aim of this study is to evaluate the clinical results of patients with prolonged retention of the same.

Methods: Patients selected were diagnosed with post-osteosynthesis infection and/or osteomyelitis and were submitted to treatment using an orthopedic cement spacer (polymethylmethacrylate) with vancomycin, retaining it for a period of more than 12 months. Read More

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http://dx.doi.org/10.1590/1413-785220192701213649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362697PMC
February 2019

Trauma-associated Pott's puffy tumor: an ophthalmologic perspective.

Orbit 2019 Feb 18:1-3. Epub 2019 Feb 18.

a Division of Ophthalmology , Ann & Robert H. Lurie Children's Hospital of Chicago , Chicago , IL , USA.

Pott's puffy tumor is a significant complication of frontal sinusitis that leads to frontal bone osteomyelitis and can be associated with frontal swelling, subperiosteal abscess, and intracranial abscess. It may be associated with antecedent trauma and typically presents in adolescents. Orbital involvement is rarely reported. Read More

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http://dx.doi.org/10.1080/01676830.2019.1573909DOI Listing
February 2019

Antibiotic Penetration into Bone and Joints: An Updated Review.

Int J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.

Treatment of bone and joint infections can be challenging as antibiotics should penetrate through the rigid bone structure and into the synovial space. Several pharmacokinetic studies measured the extent of penetration of different antibiotics into bone and joint tissues. This review discusses the results of these studies and compares them with minimum inhibitory concentrations (MIC) of common pathogens implicated in bone and joint infections in order to determine which antibiotics may have a greater potential in the treatment of such infections. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.005DOI Listing
February 2019

Ankle fusion following failed initial treatment of complex ankle fractures in neuropathic diabetics.

Foot Ankle Surg 2019 Feb 5. Epub 2019 Feb 5.

The Department of Orthopaedic Surgery and Rehabilitation, Loyola University Health System, 2160 South First Avenue, Maywood, IL 60153, United States. Electronic address:

Background: Unstable ankle fractures in diabetics with peripheral neuropathy have an increased risk of postoperative complications, often leading to amputation. Primary ankle arthrodesis has been suggested as an alternative when acceptable reduction and mechanical stabilization cannot be obtained.

Methods: Over a fourteen year period, thirteen diabetic patients with peripheral neuropathy underwent an attempt at primary ankle arthrodesis following the early post-fracture development of acute neuropathic (Charcot) deformity of the ankle after sustaining a low energy unstable ankle fracture. Read More

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http://dx.doi.org/10.1016/j.fas.2019.01.010DOI Listing
February 2019

Modular megaprosthesis as definite treatment of femur osteomyelitis.

G Chir 2019 Jan-Feb;40(1):49-53

Chronic osteomyelitis represents a challenging to treat clinical entity. A case of a whole femur chronic osteomyelitis, definitely treated with total femur resection and a positioning of a modular megaprosthesis in 2 stages is presented. An 81-year-old female, with hip hemiarthroplasty and internal fixation plate of the distal femur presented with signs and symptoms of femur osteomyelitis. Read More

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February 2019

Spondylodiscitis in end-stage renal disease: a systematic review.

J Neurosurg Spine 2019 Feb 15:1-9. Epub 2019 Feb 15.

1Department of Neurological Surgery, University of Miami, Miami, Florida; and.

OBJECTIVEDiscitis and osteomyelitis are seen in end-stage renal disease (ESRD) patients due to repeated vascular access for hemodialysis and urinary tract infections leading to recurrent bacteremia. Discitis and osteomyelitis are underdiagnosed due to the nonspecific initial presentation of back pain. In this article, we review the literature for better understanding of the problem and the importance of early diagnosis by primary care physicians and nephrologists. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18824DOI Listing
February 2019

An in vitro biofilm model of Staphylococcus aureus infection of bone.

Lett Appl Microbiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Applied Sciences, University of the West of England, Bristol, Frenchay Campus, Coldharbour Lane, Bristol, BS16 1QY.

Chronic osteomyelitis is difficult to treat, with biofilm growth and the diffusion barrier to antibiotics presented by bone contributory factors. The aim of this study was to develop and evaluate an in vitro model of osteomyelitis. A bioluminescent strain of Staphylococcus aureus was grown in bone blocks made from bovine femur. Read More

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http://dx.doi.org/10.1111/lam.13131DOI Listing
February 2019

Development of Charcot Neuroarthropathy in Diabetic Patients who Received Kidney or Kidney-Pancreas Transplants.

J Foot Ankle Surg 2019 Feb 11. Epub 2019 Feb 11.

Assistant Professor, Podiatric Medicine and Surgery Residency Program, The Ohio State University Wexner Medical Center, Columbus, OH.

Only a small percentage of the general diabetic population develops Charcot neuroarthropathy. Charcot arthropathy greatly increases the risk of foot complications. At our academic institution, there appeared to be an increased incidence of Charcot arthropathy in transplant patients. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.09.022DOI Listing
February 2019

Actinomyces Orbital Osteomyelitis in the Setting of Multiple Myeloma and Bisphosphonate-Related Osteonecrosis.

J Neuroophthalmol 2019 Mar;39(1):120-121

Department of Ophthalmology, Saint Louis University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1097/WNO.0000000000000729DOI Listing

The Incidence of Pin Tract Infections and Septic Arthritis in Percutaneous Distal Femur Pinning.

J Pediatr Orthop 2019 Feb 11. Epub 2019 Feb 11.

Children's Orthopaedic Center, Children's Hospital Los Angeles, Los Angeles, CA.

Background: Retrograde percutaneous pinning often involves intra-articular pin placement. Classic teaching has cautioned about the risk of septic arthritis with intra-articular pins, although an incidence has not been reported for this complication. The purpose of this study was to determine the incidence of pin tract infections and septic arthritis following retrograde percutaneous pinning of the distal femur. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001346DOI Listing
February 2019
3 Reads

Hand Ischemia due to Steal Syndrome Associated with Multiple Arteriovenous Malformations in a Patient with Parkes-Weber Syndrome.

J Hand Surg Asian Pac Vol 2019 Mar;24(1):89-92

† Section of Vascular Surgery and Endovascular Therapy, Mexico City, Mexico.

Parkes Weber Syndrome (PWS) is a congenital disorder characterized by the presence of arteriovenous malformations (AVMs) in upper or lower extremities. We herein present a 35 year-old male with PWS with complex AVMs in the right upper extremity; he had been previously treated with multiple sessions of vessel embolization, sclerotherapy and AVM resections. The patient presented to our clinic with two month history of progressive hand ischemia, digit necrosis and infection. Read More

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http://dx.doi.org/10.1142/S2424835519720019DOI Listing
March 2019
1 Read

Predicting Amputation and Multiple Debridements in Tooth Knuckle Injuries.

J Hand Surg Asian Pac Vol 2019 Mar;24(1):6-12

* College of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia.

Background: Tooth knuckle injuries can be expensive to treat and may necessitate amputation in some cases. Several limitations exist in the literature regarding our knowledge around the factors predicting amputation and the need for multiple debridements in treating this injury.

Methods: A historic cohort study of 321 patients treated for tooth knuckle injuries was undertaken. Read More

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http://dx.doi.org/10.1142/S2424835519500024DOI Listing

Cutibacterium (formerly Propionibacterium) acnes clavicular infection.

J Bone Jt Infect 2019 29;4(1):40-49. Epub 2019 Jan 29.

University of California San Francisco, Department of Orthopaedic Surgery.

(formerly ) is a slow growing, gram-positive bacteria that is naturally found in higher concentrations as skin flora on the chest and back, as well as in other areas with greater numbers of hair follicles. Most of the reported cases of shoulder girdle infection follow arthroplasty surgery, which then often requires debridement, administration of intravenous antibiotics, and surgical revision of the implanted device. In a recent study, 56% of 193 shoulder revisions had a positive culture, 70% of which grew . Read More

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http://dx.doi.org/10.7150/jbji.29153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367193PMC
January 2019

Brodie's Abscess: A Systematic Review of Reported Cases.

J Bone Jt Infect 2019 24;4(1):33-39. Epub 2019 Jan 24.

St Antonius Hospital Nieuwegein, Department of Surgery, The Netherlands.

Brodie's abscess is a form of osteomyelitis. Since its first appearance in the medical literature in 1832, numerous cases have been described. The aim of this article is to provide the first comprehensive overview of published cases of Brodie's abscess, and to describe diagnostic methods, therapeutic consequences and outcomes. Read More

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http://dx.doi.org/10.7150/jbji.31843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367194PMC
January 2019

L-shaped corticotomy with bone flap sliding in the management of chronic tibial osteomyelitis: surgical technique and clinical results.

J Orthop Surg Res 2019 Feb 12;14(1):47. Epub 2019 Feb 12.

Orthopaedic Department, Minhang Branch, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.

Background: We described the use of the technique of L-shaped corticotomy with bone flap sliding to treat chronic osteomyelitis of the tibia in eight patients and presented the preliminary results.

Methods: L-shaped corticotomy with bone flap sliding was performed in eight patients between 2007 and 2014. All patients had chronic tibial osteomyelitis involving the anterior tibial cortex with intact and healthy posterior cortex. Read More

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http://dx.doi.org/10.1186/s13018-019-1086-0DOI Listing
February 2019

Experimental Candida albicans osteomyelitis: Microbiologic, antigenic, histologic, and 18FDG-PET-CT imaging characteristics in a newly established rabbit model.

Med Mycol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Candida osteomyelitis is a debilitating disease that is difficult to diagnose and treat. As there are no animal models or prospective studies for this uncommon infection, little is known about the pathogenesis, diagnosis, or treatment. We therefore sought to establish an animal model for the study of the pathophysiology, diagnostic modalities, and therapeutic interventions of Candida osteomyelitis. Read More

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http://dx.doi.org/10.1093/mmy/myz001DOI Listing
February 2019
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Clinical and Microbiologic Variables Predictive of Orthopedic Complications Following S. aureus Acute Hematogenous Osteoarticular Infections in Children.

Clin Infect Dis 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX.

Background: Staphylococcus aureus is the most common cause of acute hematogenous osteoarticular infections (AHOAIs) in children. The risk factors for the development of orthopedic complications (OC) after AHOAI are poorly understood. We sought to describe clinical and microbiologic variables present on the index admission which may predict OC in S. Read More

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http://dx.doi.org/10.1093/cid/ciz109DOI Listing
February 2019
1 Read

Reevaluating Magnetic Resonance Imaging in Radiographically Suspected Osteomyelitis of the Toe.

J Am Podiatr Med Assoc 2018 Nov;108(6):472-477

Background:: Magnetic resonance imaging (MRI) is both sensitive and specific in the diagnosis of osteomyelitis, and it is an important imaging modality in preoperative planning of resection of infected bone. In many cases, however, the extent of osseous infection is evident on plain radiographs, and little additional information is gained from the MRI. The goal of this study was to assess the accuracy of radiographs against MRIs in assessing the spread of suspected osteomyelitis from one phalanx to another or to a metatarsal. Read More

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http://dx.doi.org/10.7547/16-148DOI Listing
November 2018

Parvimonas micra Spondylodiscitis: A Case Report and Systematic Review of the Literature.

J Orthop Case Rep 2018 Sep-Oct;8(5):67-71

Department of Orthopaedic Surgery, MOVE Research Institute Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.

Introduction: Treatment and risk factors for Parvimonas micra spinal infections are scarcely researched. This study reports a case and presents a systematic review of the literature to provide evidence-based ground for diagnosis and treatment of P. micra spinal infections. Read More

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http://dx.doi.org/10.13107/jocr.2250-0685.1216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367290PMC
February 2019
7 Reads

Lengthening of free fibular grafts for reconstruction of the residual leg length discrepancy.

BMC Musculoskelet Disord 2019 Feb 8;20(1):66. Epub 2019 Feb 8.

Department of Orthopedics, The Second Xiangya Hospital of Central South University, 139# Middle Renmin Road, Changsha, Hunan, 410011, People's Republic of China.

Background: We evaluated our results of lengthening of free vascularized fibular grafts using a unilateral external fixator in patients with residual leg length discrepancy after free vascularized fibular graft for lower limb reconstruction.

Cases Presentation: Two patients were administrated to our hospital with residual tibial length discrepancy after vascularized free fibular graft surgery. Lengthening of the free vascularized fibular graft with a unilateral external fixator was performed to correct the leg length discrepancy. Read More

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http://dx.doi.org/10.1186/s12891-019-2445-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368813PMC
February 2019

Selection of an appropriate empiric antibiotic regimen in hematogenous vertebral osteomyelitis.

PLoS One 2019 8;14(2):e0211888. Epub 2019 Feb 8.

Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea.

Background: Empiric antibiotic therapy for suspected hematogenous vertebral osteomyelitis (HVO) should be initiated immediately in seriously ill patients and may be required in those with negative microbiological results. The aim of this study was to inform the appropriate selection of empiric antibiotic regimens for the treatment of suspected HVO by analyzing antimicrobial susceptibility of isolated bacteria from microbiologically proven HVO.

Method: We conducted a retrospective chart review of adult patients with microbiologically proven HVO in five tertiary-care hospitals over a 7-year period. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211888PLOS
February 2019

Pyogenic sacroiliitis in children: don't forget the very young.

Eur J Pediatr 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatrics, Mount Scopus Hadassah-Hebrew University Medical Center, 91120, Jerusalem, Israel.

Pyogenic sacroiliitis (PS) is rare with less than 100 pediatric cases reported in the medical literature. To better characterize PS in the pediatric population, we investigated a series of children presenting with PS. Retrospective data analysis was done at an academic tertiary center between the years of 2000 and 2017. Read More

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http://dx.doi.org/10.1007/s00431-019-03333-8DOI Listing
February 2019
2 Reads

Chronic Candida osteomyelitis of hard palate and nose: A diagnostic quandary.

Med Mycol Case Rep 2019 Jun 14;24:1-4. Epub 2019 Jan 14.

Department of Microbiology, All India Institute of Medical Sciences, Jodhpur 2, Basni, Jodhpur 342005, India.

induced osteomyelitis is infrequent. There is scarcity of literature on this entity in maxillofacial region and thus there is possibility to mismanage such cases. We are presenting a case of chronic maxillofacial osteomyelitis causing palatal and septal perforation with saddle nose deformity in a young lady with commencement and progression of disease process over two pregnancies. Read More

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http://dx.doi.org/10.1016/j.mmcr.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357845PMC
June 2019
1 Read

Surgery is safe and effective when indicated in the acute phase of hematogenous pyogenic vertebral osteomyelitis.

Infect Dis (Lond) 2019 Feb 7:1-9. Epub 2019 Feb 7.

a Service de Médecine Interne, Hôpital Beaujon, Assistance Publique Hôpitaux de Paris , Clichy , France.

Background: The overall benefit of surgical management in the acute phase of hematogenous pyogenic vertebral osteomyelitis remains difficult to evaluate because of the balance between potential functional benefit versus complications of surgery.

Methods: Between 2000 and 2013, in a tertiary care hospital, we analyzed a cohort of patients with hematogenous pyogenic vertebral osteomyelitis treated surgically and compared them to those treated medically. Neurologic deficit (using the ASIA impairment scale) and pain (using the analgesic level required) 4 months later, recurrences and infection-related deaths 12 months later were evaluated. Read More

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http://dx.doi.org/10.1080/23744235.2018.1562206DOI Listing
February 2019

Reconstruction of Acquired Frontal Bone Defects Using Titanium Mesh Implants: A Retrospective Study.

J Maxillofac Oral Surg 2019 Mar 22;18(1):34-39. Epub 2018 Jan 22.

Department of General Dentistry, Dr S.N. Medical College, Shastri Nagar, Jodhpur, Rajasthan 342001 India.

Purpose: Frontal bone deformities can be acquired due to trauma or ablative tumor resection surgeries and osteomyelitis. It may also occur due to congenital malformations. Repair of these defects have long been a challenge to oral and maxillofacial surgeons. Read More

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http://dx.doi.org/10.1007/s12663-018-1083-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328812PMC

Orocutaneous fistulas of odontogenic origin presenting as a recurrent pyogenic granuloma.

Arch Craniofac Surg 2019 Feb 7. Epub 2019 Feb 7.

Department of Plastic and Reconstructive Surgery, Inje University Haeundae Paik Hospital, Busan, Korea.

Orocutaneous fistulas, or cutaneous sinuses of odontogenic origin, are uncommon but often misdiagnosed as skin lesions unrelated to dental origin by physicians. Accurate diagnosis and use of correct investigative modalities are important because orocutaneous fistulas are easily confused for skin or bone tumors, osteomyelitis, infected cysts, salivary gland fistulas, and other pathologies. The aim of this study is to present our experience with a patient with orocutaneous fistulas of odontogenic origin presenting as recurrent pyogenic granuloma of the cheek, and to discuss their successful treatment. Read More

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http://dx.doi.org/10.7181/acfs.2018.01991DOI Listing
February 2019

Unilateral hearing loss in a 94-year-old patient.

Age Ageing 2019 Feb 6. Epub 2019 Feb 6.

Department of Geratology, John Radcliffe Hospital Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

A case report of a 94-year-old, previously well male patient who presented with fever thought to be caused by community acquired pneumonia, new unilateral hearing loss and reduced consciousness. Despite antibiotic treatment he continued to deteriorate. Brain imaging with computer tomography and magnetic resonance imaging revealed a left otomastoiditis with osteomyelitis of the skull base, associated with an adjacent subdural empyema. Read More

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http://dx.doi.org/10.1093/ageing/afz003DOI Listing
February 2019
2 Reads

[The Physiotherapy in the treatment of alveolitis and localized osteomyelitis of the jawbones].

Vopr Kurortol Fizioter Lech Fiz Kult 2019 ;96(1):11-21

'Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University' of the Ministry of Health of the Russian Federation, Moscow, Russia.

Background: Alveolitis and localized osteomyelitis of the jawbones still remain the most common conditions among the post-operative complications associated with tooth extraction.

Aim: The objective of the present study was to evaluate the antibacterial and clinical effectiveness of ozone therapy and radiation of various wavelengths emitted by the light-emitting diodes (LED) applied for the treatment of alveolitis and localized osteomyelitis of the jawbone with a view to improving the effectiveness of the treatment and shortening the duration of the rehabilitation period.

Material And Methods: A total of 100 patients presenting with alveolitis and localized osteomyelitis of the jawbones at the age varying from 18 to 65 years have been examined and treated. Read More

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http://dx.doi.org/10.17116/kurort20199601111DOI Listing
January 2019

The use of bioactive glass S53P4 in the treatment of an infected Charcot foot: a case report.

J Wound Care 2019 Jan;28(Sup1):S14-S17

Southwestern Academic Limb Salvage Alliance (SALSA), Department of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA, US.

Objective:: To report a case of successful limb-salvage staged treatment in the treatment of an infected diabetic Charcot foot.

Case Summary:: A 45-year-old male with long-term, uncontrolled type 2 diabetes, six months' history of progressive deformity on the right foot and 45 days of purulent drainage in the lateral aspect of the foot. Patient was diagnosed with an infected Charcot foot with extensive midfoot bone involvement as shown by radiographic and MRI images. Read More

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http://dx.doi.org/10.12968/jowc.2019.28.Sup1.S14DOI Listing
January 2019
2 Reads

Oral Amoxicillin/Clavulanate for Treating Diabetic Foot Infections.

Diabetes Obes Metab 2019 Feb 5. Epub 2019 Feb 5.

Service of Infectious Diseases, Geneva University Hospitals, Geneva.

Some clinicians avoid amoxicillin-clavulanate (AMC) for the oral therapy of diabetic foot infections (DFI), especially for osteomyelitis (DFO), due to its poor bioavailability and bone penetration of all antibiotics from the β-lactam class. We performed a retrospective cohort analysis among 794 DFI episodes, including 339 DFO cases. The median duration of antibiotic therapy after surgical debridement (including partial amputation) was 30 days (DFO 30 days). Read More

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http://dx.doi.org/10.1111/dom.13651DOI Listing
February 2019
7 Reads
6.360 Impact Factor

Discordant isolates in bone specimens from patients with recurrent foot osteomyelitis.

Eur J Clin Microbiol Infect Dis 2019 Feb 5. Epub 2019 Feb 5.

Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard (OCL 112), Houston, TX, 77030, USA.

We compared paired operative bone cultures (initial operation and reoperation) for 35 patients who experienced foot osteomyelitis treatment failure at a single hospital. Concordance was poor (kappa = 0.180). Read More

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http://dx.doi.org/10.1007/s10096-019-03470-wDOI Listing
February 2019
1 Read

Osteomyelitis: A Rare Complication After Subpectoral Biceps Tenodesis.

Orthop J Sports Med 2019 Jan 16;7(1):2325967118822732. Epub 2019 Jan 16.

Department of Orthopaedics, UT Health San Antonio, San Antonio, Texas, USA.

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http://dx.doi.org/10.1177/2325967118822732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348516PMC
January 2019

Increased Fragility Fracture Rates in Older Men with Osteomyelitis.

Clin Infect Dis 2019 Feb 2. Epub 2019 Feb 2.

Division of Infectious Diseases, Columbia University Medical Center, New York, NY, USA.

This study evaluated fracture incidence over a 10-year period among men with and without osteomyelitis from the Veterans Aging Cohort Study. Fracture incidence was significantly higher among those with osteomyelitis at all osteoporotic fracture sites after adjusting for key related risk factors. Future prospective studies are warranted. Read More

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http://dx.doi.org/10.1093/cid/ciz077DOI Listing
February 2019

Effect of Causative Micro-organisms on Patterns of Labeled White Blood Cells in Osteomyelitis.

Indian J Nucl Med 2019 Jan-Mar;34(1):27-31

Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, Kuwait.

Objective: The aim of this study is to investigate the effect of microbiological characteristics of causative organisms on the scintigraphic patterns of labeled-white blood cells (WBC) scan in cases of proven osteomyelitis.

Materials And Methods: Retrospective analysis of 25 patients referred with suspected osteomyelitis and had both bone and labeled-WBC scans performed and complete records of the microbiological culture of the causative organism. The bone and labeled-WBC scans were retrieved and reviewed by two nuclear medicine physicians. Read More

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http://dx.doi.org/10.4103/ijnm.IJNM_117_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352629PMC
February 2019

Clinically Infrequent Arcanobacterium haemolyticumBacteremia Complicated by Foot Decubitus Ulcer: An Educational Reminder for Primary Care Physicians.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Center for Global Health, Mito Kyodo General Hospital, University of Tsukuba, Japan.

An 81-year-old Japanese man with no history of diabetes mellitus was admitted to our hospital for a fever with a new ulcerative lesion on the left heel. Blood cultures on admission grew Arcanobacterium haemolyticum in aerobic bottles. He was therefore diagnosed with A. Read More

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http://dx.doi.org/10.2169/internalmedicine.2162-18DOI Listing
February 2019
1 Read

Single-stage treatment of infected tibial non-unions and osteomyelitis with bone marrow granulocytes precursors protecting bone graft.

Int Orthop 2019 Feb 2. Epub 2019 Feb 2.

Department of Orthopaedics, The Second Xiangya Hospital of Central South University, No. 139 Remin Road, Changsha, 410011, Hunan Province, China.

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http://dx.doi.org/10.1007/s00264-019-04304-2DOI Listing
February 2019

Biomaterial-assisted local and systemic delivery of bioactive agents for bone repair.

Acta Biomater 2019 Jan 31. Epub 2019 Jan 31.

Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27710, USA; Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27710, USA; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA. Electronic address:

Although bone tissues possess an intrinsic capacity for repair, there are cases where bone healing is either impaired or insufficient, such as fracture non-union, osteoporosis, osteomyelitis, and cancers. In these cases, treatments like surgical interventions are used, either alone or in combination with bioactive agents, to promote tissue repair and manage associated clinical complications. Improving the efficacy of bioactive agents often requires carriers, with biomaterials being a pivotal player. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.060DOI Listing
January 2019

Endodontic Infection-induced Inflammation Resembling Osteomyelitis of the Jaws in Toll-like Receptor 2/Interleukin 10 Double-knockout Mice.

J Endod 2019 Feb;45(2):181-188

Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts; Department of Endodontics, Boston University Goldman School of Dental Medicine, Boston, Massachusetts.

Introduction: In general, mice develop chronic and nonhealing periapical lesions after endodontic infection. Surprisingly, we recently found that toll-like receptor 2 (TLR2)/interleukin 10 (IL-10) double-knockout (dKO) mice exhibited acute but resolving osteomyelitislike inflammation. In this study, we examined the kinetics of endodontic infection-induced inflammation in TLR2/IL-10 dKO mice and explored a potential mechanism of periapical wound healing mediated by the hypoxia-inducible factor 1 alpha (HIF-1α) subunit and arginase 1. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364571PMC
February 2019
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Imaging of Acute Low Back Pain.

Radiol Clin North Am 2019 Mar 5;57(2):397-413. Epub 2018 Dec 5.

Department of Radiology and Imaging Sciences, University of Utah, 30 North 1900 East, Room 1A71, Salt Lake City, UT 84132, USA. Electronic address:

Acute low back pain, defined as less than 6 weeks in duration, does not require imaging in the absence of "red flags" that may indicate a cause, such as fracture, infection, or malignancy. When imaging is indicated, it is important to rule out a host of abnormalities that may be responsible for the pain and any associated symptoms. A common mnemonic VINDICATE can help ensure a thorough consideration of the possible causes. Read More

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http://dx.doi.org/10.1016/j.rcl.2018.10.001DOI Listing
March 2019
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Collagen scaffolds functionalised with copper-eluting bioactive glass reduce infection and enhance osteogenesis and angiogenesis both in vitro and in vivo.

Biomaterials 2019 Mar 23;197:405-416. Epub 2019 Jan 23.

Tissue Engineering Research Group (TERG), Dept. of Anatomy, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland; Trinity Centre for BioEngineering (TCBE), Trinity College Dublin (TCD), Dublin, Ireland; Advanced Materials and BioEngineering Research Centre (AMBER), RCSI & TCD, Dublin, Ireland. Electronic address:

The bone infection osteomyelitis (typically by Staphylococcus aureus) usually requires a multistep procedure of surgical debridement, long-term systemic high-dose antibiotics, and - for larger defects - bone grafting. This, combined with the alarming rise in antibiotic resistance, necessitates development of alternative approaches. Herein, we describe a one-step treatment for osteomyelitis that combines local, controlled release of non-antibiotic antibacterials with a regenerative collagen-based scaffold. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.031DOI Listing

Tetrachromic VOF/Masson's trichrome/H and E stains: Unmasking their usability in differential stromal hard tissue staining.

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):67-72

Department of Oral Pathology and Microbiology, ITS-CDSR, Muradnagar, Ghaziabad, Uttar Pradesh, India.

Background: Identification and differentiation of stromal hard tissue components is a challenging task. Numerous methods of demonstrating these components have been worked upon in the past. Although some of the methods have been successful, there are many drawbacks of employing them. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_242_18DOI Listing
February 2019

The role of real-time PCR testing in the investigation of paediatric patients with community-onset osteomyelitis and septic arthritis.

Ir J Med Sci 2019 Jan 31. Epub 2019 Jan 31.

Irish Meningitis and Sepsis Reference Laboratory, Temple Street Children's University Hospital, Dublin 1, Ireland.

Background: Culture yield in osteomyelitis and septic arthritis is low, emphasising the role for molecular techniques.

Aims: The purpose of this study was to review the laboratory investigation of childhood osteomyelitis and septic arthritis.

Methods: A retrospective review was undertaken in an acute tertiary referral paediatric hospital from January 2010 to December 2016. Read More

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http://link.springer.com/10.1007/s11845-019-01973-1
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http://dx.doi.org/10.1007/s11845-019-01973-1DOI Listing
January 2019
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Post-traumatic osteomyelitis in Middle East war-wounded civilians: resistance to first-line antibiotics in selected bacteria over the decade 2006-2016.

BMC Infect Dis 2019 Jan 31;19(1):103. Epub 2019 Jan 31.

Epicentre, 55 rue Crozatier, 75012, Paris, France.

Background: War-wounded civilians in Middle East countries are at risk of post-traumatic osteomyelitis (PTO). We aimed to describe and compare the bacterial etiology and proportion of first-line antibiotics resistant bacteria (FLAR) among PTO cases in civilians from Syria, Iraq and Yemen admitted to the reconstructive surgical program of Médecins Sans Frontières (MSF) in Amman, Jordan, and to identify risk factors for developing PTO with FLAR bacteria.

Methods: We retrospectively analyzed the laboratory database of the MSF program. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3741-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357381PMC
January 2019
5 Reads

Assessing the fusion of the ischiopubic synchondrosis using predictive modeling.

Clin Anat 2019 Jan 30. Epub 2019 Jan 30.

School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, 4001, Australia.

Introduction: Flaring of the ischiopubic synchondrosis at the time of fusion is a common clinical observation in pediatrics and represents a normal physiological process in skeletal maturation. When presenting unilaterally, this flaring can mimic a range of serious pathological conditions such as osteomyelitis, osteal tumors and traumatic injury. An improved understanding of ischiopubic synchondrosis fusion is therefore critical to avoid potential misdiagnosis. Read More

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http://doi.wiley.com/10.1002/ca.23345
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http://dx.doi.org/10.1002/ca.23345DOI Listing
January 2019
7 Reads