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Gerodontology 2022 Jun;39(2):213-217

Director of Oral and Maxillofacial Radiology, Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.

Introduction: Miliary osteoma cutis (MOC) is a cutaneous disorder that develops in response to an ill-defined process or following acne vulgaris. Most cases present incidentally as small radiographic aggregations of normal bone within the cheeks. Infrequently, MOC has been reported with systemic disease, including renal failure. Read More

BMC Endocr Disord 2022 Mar 16;22(1):70. Epub 2022 Mar 16.

Department of Endocrinology and Metabolism, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dongfang Road, Shanghai, 200127, China.

Background: The GNAS gene on chromosome 20q13.3, encodes the alpha-subunit of the stimulatory G protein, which is expressed in most tissues and regulated through reciprocal genomic imprinting. Disorders of GNAS inactivation produce several different clinical phenotypes including pseudohypoparathyroidism (PHP), pseudopseudohypoparathyroidism (PPHP), progressive osseous heteroplasia (POH), and osteoma cutis (OC). Read More

JAAD Case Rep 2022 Apr 31;22:2-4. Epub 2022 Jan 31.

Department of Dermatology, Hospital Corporation of America Healthcare/University of South Florida Morsani College of Medicine GME: Largo Medical Center, Largo, Florida.

Hautarzt 2022 Feb 14;73(2):127-137. Epub 2022 Jan 14.

Dermatologie II, Colentina Klinik, Carol-Davila-Universität für Medizin und Pharmazie, Stefan cel Mare Street 19-21, 020125, Bukarest, Rumänien.

There are many different types of skin neoplasms in children and most are benign. Dermatologists should be able to differentiate between the various types of benign skin neoplasms and be able to recommend optimal treatment to concerned patients. Surgical removal of benign skin neoplasms is often the only treatment option. Read More

J Cosmet Dermatol 2022 Jan 30;21(1):407-409. Epub 2021 Oct 30.

Department of Pathology, Acıbadem Mehmet Ali Aydınlar University Medical School, Istanbul, Turkey.

Clin Cosmet Investig Dermatol 2021 22;14:1331-1335. Epub 2021 Sep 22.

Department of Dermatologic Surgery and Skin Tumors, Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.

Osteoma cutis (OC) is a group of rare skin ossification diseases, most of which are secondary to inflammation, scarring, trauma, or tumors, but a small portion are primary. Plate-like osteoma cutis is rare, especially after puberty. This report documents a case of a 30-year-old female, who presented with multiple stone-hard plates on the forehead and bilateral temples, with no relevant family history, or abnormalities in metabolism. Read More

Clin Exp Dermatol 2021 Oct 21;46(7):1384-1386. Epub 2021 Aug 21.

Departments of, Dermatology, Addenbrooke's Hospital, Cambridge, UK.

Ophthalmic Plast Reconstr Surg 2021 Sep-Oct 01;37(5):e187-e188

Departments of Ophthalmology.

Osteoma cutis is a term applied to bone formation in the dermis or subcutaneous tissue. It is deemed primary when occurring de novo without prior disease or secondary when associated with pre-existing inflammation, neoplasia or trauma. The authors describe a longstanding focal calcified and ossified lesion of the upper eyelid in a healthy 10-year-old girl along with a sterile corneal ulcer. Read More

Endocrine 2021 12 13;74(3):685-689. Epub 2021 Jul 13.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Purpose: Progressive osseous heteroplasia (POH), a genetic disorder, is associated with Albright's hereditary osteodystrophy (AHO), pseudohypoparathyroidism, and primary osteoma cutis and has common features of superficial ossification and GNAS-inactivating mutations. Disorders due to GNAS-inactivating mutations are classified as "inactivating parathyroid hormone (PTH)/PTHrP signaling disorder type 2." This study reports a case of mild POH overlap syndrome to improve understanding of genotype-phenotype correlations. Read More

AACE Clin Case Rep 2021 May-Jun;7(3):180-183. Epub 2021 Jan 7.

Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California.

Objective: We present a patient with pseudopseudohypoparathyroidism (PPHP) who developed both gout and synovial chondromatosis, in addition to the classical Albright's hereditary osteodystrophy phenotype.

Methods: The patient's clinical course, laboratory data, and imaging are presented.

Results: The patient is a 40-year-old male with no pertinent family history who presented with findings of Albright's hereditary osteodystrophy, including short stature, obesity, rounded face, shortened fourth and fifth digits, and osteoma cutis (heterotopic subcutaneous ossification), which required surgical removal for pain relief. Read More

Skin Appendage Disord 2021 Apr 27;7(3):216-219. Epub 2021 Jan 27.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Osteoma cutis (OC) or cutaneous ossification refers to uncommon bone formation in the skin. Primary OC develops without any predisposing factor or pre-existing lesion, whereas secondary OC sets out as a dystrophic ossification following traumatic, cicatricial, and neoplastic factors or other cutaneous inflammations. Herein, we report a rare case of long-standing progressive primary OC of the scalp resected in 3 sessions with no recurrence after 1 year. Read More

Am J Dermatopathol 2021 08;43(8):579-582

Department of Dermatology, Keck School of Medicine at the University of Southern California, Los Angeles, CA.

Abstract: Parenteral gold has historically been used to treat several conditions, including rheumatoid arthritis. Gold administration leads to a variety of cutaneous reactions, including chrysiasis, which is a permanent blue-grey hyperpigmentation of the skin due to dermal gold deposition. In this report, we describe the case of a patient who received parenteral gold injections 22 years before the onset of her chrysiasis for the treatment of rheumatoid arthritis. Read More

An Pediatr (Engl Ed) 2021 Apr 21. Epub 2021 Apr 21.

Servicio de Pediatría, Unidad de Endocrinología Infantil, Hospital Universitario Son Espases, Palma de Mallorca, Islas Baleares, España.

Dermatol Online J 2021 Feb 15;27(2). Epub 2021 Feb 15.

San Diego Family Dermatology, National City, CA Touro University California College of Osteopathic Medicine, Vallejo, CA.

Basal cell carcinoma (BCC) can be a component of a collision tumor in which the skin cancer is present at the same cutaneous site as either a benign tumor or a malignant neoplasm. However, BCC can also concurrently occur at the same skin location as a non-neoplastic cutaneous condition. These include autoimmune diseases (vitiligo), cutaneous disorders (Darier disease), dermal conditions (granuloma faciale), dermal depositions (amyloid, calcinosis cutis, cutaneous focal mucinosis, osteoma cutis, and tattoo), dermatitis, miscellaneous conditions (rhinophyma, sarcoidal reaction, and varicose veins), scars, surgical sites, systemic diseases (sarcoidosis), systemic infections (leischmaniasis, leprosy and lupus vulgaris), and ulcers. Read More

J Clin Aesthet Dermatol 2020 Nov 1;13(11):28-31. Epub 2020 Nov 1.

Drs. Niebel, Poortinga, and Wenzel are with the Department of Dermatology and Allergy, University Hospital Bonn at Bonn University in Bonn, Germany.

The development of calcium salt deposits in the skin can occur in the presence or absence of membranous ossification and are categorized into osteoma cutis (i.e., cutaneous osteoma) and calcinosis cutis. Read More

Endocrine 2021 06 11;72(3):611-618. Epub 2020 Nov 11.

Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Pseudohypoparathyroidism (PHP), the first known post-receptorial hormone resistance, derives from a partial deficiency of the α subunit of the stimulatory G protein (Gsα), a key component of the PTH/PTHrP signaling pathway. Since its first description, different studies unveiled, beside the molecular basis for PHP, the existence of different subtypes and of diseases in differential diagnosis associated with genetic alterations in other genes of the PTH/PTHrP pathway. The clinical and molecular overlap among PHP subtypes and with different but related disorders make both differential diagnosis and genetic counseling challenging. Read More

Ital J Dermatol Venerol 2021 06 21;156(3):409-411. Epub 2020 Oct 21.

Oasi Research Institute and IRCCS, Troina, Enna, Italy.

Indian Dermatol Online J 2020 Jul-Aug;11(4):604-606. Epub 2020 Jul 13.

Department of Skin and V.D., S.C.B.M.C.H., Cuttack, Odisha, India.

Progressive osseous heteroplasia (POH) is a rare genetic condition of progressive extraskeletal bone formation. POH is clinically suspected by cutaneous ossification, usually presenting in early life, that involves subcutaneous and then subsequently deep connective tissues, including muscle and fascia. We report a case of POH in a 3-year-old child with multiple nontender subcutaneous nodules which, on radiology and histopathology, showed intracutaneous bone formation. Read More

J Dtsch Dermatol Ges 2020 09 18;18(9):1046-1049. Epub 2020 Jun 18.

Unidad de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario San Cecilio, Granada, Spain.

Niger J Clin Pract 2020 Jun;23(6):759-763

Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey.

Objective: The aim of this study was to detect the prevalence of soft tissue calcifications in the head and neck using cone beam computed tomography (CBCT) and to determine their clinical importance.

Subjects And Methods: Soft tissue calcifications in the head and neck region were retrospectively evaluated in 1557 CBCT images obtained between 2013 and 2015. The findings were categorized as follows: tonsillolith (calcified tonsil), carotid artery calcification (CAC), sialolith (salivary stone), calcified triticeous cartilage (CTC), calcified lymph node (CLN), rhinolith, antrolith, calcification of the superior cornu of the thyroid cartilage (CSCTC), calcified stylohyoid ligaments (CSL), myositis ossifican, osteoma cutis, and intracranial calcification. Read More

J Cutan Pathol 2020 Aug 7;47(8):776-777. Epub 2020 May 7.

Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.

An Bras Dermatol 2020 May - Jun;95(3):351-354. Epub 2020 Mar 19.

Service of Dermatology Surgery, Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil.

Secondary osteoma cutis is a phenomenon that may occur in several conditions. When it occurs in a melanocytic nevus it is named osteonevus of Nanta, an event considered uncommon and characterized by the presence of bone formation adjacent or interposed with melanocytic cells. There are reports of its occurrence in various melanocytic lesions, being more frequently associated with intradermal nevus. Read More

J Vet Med Sci 2020 May 2;82(5):536-540. Epub 2020 Apr 2.

Avian Pathology Laboratory, Department of Animal Health, School of Veterinary Medicine, Universidad Nacional de Colombia, Sede Bogotá, Poultry Research Building, Bogotá DC, Carrera 45 #26-85, Colombia.

An osteoma is an infrequent tumor documented in avian species. An adult female Peach-Faced Lovebird (Agapornis roseicollis) with a history of previous trauma was examined due to the presence of bilateral hard and yellowish-white masses in the radio-cubital humerus junction. Histopathological dermal examination revealed a non-neoplastic process of mesenchymal origin, characterized by the formation of well-differentiated trabecular bone, multiple areas of medullary bone and loose connective tissue and coagulation of the necrosis foci. Read More

Cureus 2020 Feb 11;12(2):e6955. Epub 2020 Feb 11.

Dermatology/Dermatopathology, Compass Dermatopathology, San Diego, USA.

Cutaneous tender tumors manifest as painful dermal or subcutaneous masses. Acronyms, a memory aid created from the initial letters of other words, can be used to assist in recalling a list of conditions. We report the case of a man who presented with a painful lesion on his leg; 15 years earlier, hot solder had embedded beneath his skin at that location. Read More

SAGE Open Med Case Rep 2020 4;8:2050313X20910562. Epub 2020 Mar 4.

Division of Dermatology, McGill University Health Centre, Montreal, QC, Canada.

Facial multiple miliary osteoma cutis is a variant of osteoma cutis usually occurring in women with a previous history of acne vulgaris. Successful ablative laser treatment has been reported using both CO2 and Er:YAG lasers among other invasive treatment modalities, like surgical removal. We report a patient with biopsy-proven facial multiple miliary osteoma cutis responding to non-ablative Q-switched Nd:YAG laser therapy. Read More

Niger J Clin Pract 2020 Mar;23(3):329-336

Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Ataturk University, Zip 25340, Erzurum, Turkey.

Objectives: The aim of this study is to determine the type, frequency, and location of incidental findings in the maxillofacial region in patients undergoing cone beam computed tomography (CBCT) scan for implant treatment..

Methods: In this study, 300 patients who underwent CBCT imaging for implant treatment planning were evaluated retrospectively. Read More

ANZ J Surg 2020 10 3;90(10):2140-2142. Epub 2020 Mar 3.

Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia.

World J Clin Cases 2020 Feb;8(3):587-593

Department of Genetics and Metabolism, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, Zhejiang Province, China.

Background: Pseudohypoparathyroidism type Ia (PHP Ia) is a rare hereditary syndrome, and patients with early PHP Ia are generally not diagnosed based on the presentation of cutaneous nodules as the main clinical feature. Here, we describe a Chinese boy with PHP Ia in whom the main clinical feature was cutaneous nodules, and the patient exhibited a novel mutation.

Case Summary: A 5-year-old boy presented with a 5-year history of cutaneous nodules scattered over his entire body. Read More

Ann Dermatol Venereol 2020 Apr 18;147(4):313-315. Epub 2020 Feb 18.

Dermatology department, Saint-Louis hospital, AP-HP, 75010 Paris, France.