7,108 results match your criteria Osteoid Osteoma Imaging


Osteocytes reflect a pro-inflammatory state following spinal cord injury in a rodent model.

Bone 2018 Dec 11. Epub 2018 Dec 11.

Department of Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center, Bryan, TX, United States of America.

Profound bone loss occurs following spinal cord injury (SCI) resulting in a high incidence of fractures. While likely caused in part by loss of weight-bearing, there is greater bone loss following SCI when compared to that observed in other disuse animal models. Patients with SCI have a protracted inflammatory response, with elevated circulating levels of pro-inflammatory markers. Read More

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December 2018

Primary Osteosarcoma of the Breast.

Indian J Surg Oncol 2018 Dec 30;9(4):578-580. Epub 2018 Jul 30.

Department of Surgical Oncology, Bombay Hospital, Bombay hospital Marg, Marine Drive, Mumbai, Maharashtra 400020 India.

Extraskeletal osteosarcomas are extremely rare and account for < 1% of the soft tissue sarcomas. Most common site is in soft tissues of the lower extremities. Primary osteosarcomas of the breast are extremely rare and only a few cases have been reported in literature. Read More

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December 2018

MiR-155 affects osteosarcoma cell proliferation and invasion through regulating NF-κB signaling pathway.

Authors:
S Lu Q-S Liao L Tang

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7633-7639

College of Optoelectronic Engineering, Health Science Center Shenzhen University, Shenzhen, Guangdong, China.

Objective: Osteosarcoma can form tumor osteoid tissue and bone tissue directly or indirectly through cartilage stage. It mainly occurs in children and adolescents with high mortality. MicroRNA (miRNA) possesses tissue sensitivity as tumor biomarker and plays a promoting or inhibitory role in tumor pathogenesis as oncogene or tumor suppressor gene. Read More

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November 2018

Role of SMPD3 during Bone Fracture Healing and Regulation of its Expression.

Mol Cell Biol 2018 Dec 10. Epub 2018 Dec 10.

Faculty of Dentistry, McGill University, Montreal, Quebec, Canada

Sphingomyelin phosphodiesterase 3 (SMPD3), a lipid-metabolizing enzyme present in bone and cartilage, has important roles in the developing skeleton. Using an inducible knockout mouse model, , where was ablated in both expressing chondrocytes and osteoblasts during early skeletogenesis, we showed that SMPD3 deficiency results in delayed extracellular matrix (ECM) mineralization and severe skeletal deformities. Interestingly, in 3-month-old mice, in which was ablated postnatally, only a mild bone mineralization defect was observed. Read More

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December 2018

Radiographically recognizable? An investigation into the appearance of osteomalacic pseudofractures.

Int J Paleopathol 2018 Jan 4. Epub 2018 Jan 4.

Department of Anthropology, McMaster University, Hamilton, Ontario, L8S 4L8, Canada.

Pseudofractures, lucent bands that occur due to a build-up of osteoid, are a key feature of osteomalacia. In paleopathology, pseudofractures are often marked by small, linear cracks in the cortex of the bone surrounded by irregular, bony spicule formation. Radiography can be used to help diagnose pseudofractures, both clinically and in paleopathology. Read More

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January 2018

Dental pulp stem cells in chitosan/gelatin scaffolds for enhanced orofacial bone regeneration.

Dent Mater 2018 Dec 6. Epub 2018 Dec 6.

Department of Materials Science and Technology, University of Crete, Heraklion, Greece; Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology Hellas (FORTH), Heraklion, Greece. Electronic address:

Objective: Biomimetic chitosan/gelatin (CS/Gel) scaffolds have attracted great interest in tissue engineering of several tissues. However, limited information exists regarding the potential of combining CS/Gel scaffolds with oral cells, such as dental pulp stem cells (DPSCs), to produce customized constructs targeting alveolar/orofacial bone reconstruction, which has been the aim of the present study.

Methods: Two scaffold types, designated as CS/Gel-0. Read More

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December 2018

An Optimized Approach to Perform Bone Histomorphometry.

Front Endocrinol (Lausanne) 2018 21;9:666. Epub 2018 Nov 21.

Experimental Trauma Surgery, Faculty of Medicine, Justus-Liebig University of Giessen, Giessen, Germany.

Bone histomorphometry allows quantitative evaluation of bone micro-architecture, bone formation, and bone remodeling by providing an insight to cellular changes. Histomorphometry plays an important role in monitoring changes in bone properties because of systemic skeletal diseases like osteoporosis and osteomalacia. Besides, quantitative evaluation plays an important role in fracture healing studies to explore the effect of biomaterial or drug treatment. Read More

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November 2018
1 Read

Motion preservation surgery: excision of juxta C5-C6 intervertebral disc osteoid osteoma using 3D C-arm based navigation: technical report.

SICOT J 2018 5;4:56. Epub 2018 Dec 5.

Mumbai Spine Scoliosis & Disc Replacement Centre, Bombay Hospital & Medical Research Center, Marine Lines, Mumbai 400002, India.

Introduction: Precise targeted excision of the C5-C6 osteoid osteoma with placement of reference array on clavicle with minimal disturbance of anatomy and motion.

Methods: A 20-year-old male presented with an osteoid osteoma in the superior end plate of the C6 vertebra abutting the spinal canal causing intractable pain. The authors curetted the nidus using a 3D C-arm-based intraoperative scan integrated with an optical navigation system through a minimal access anterior cervical exposure. Read More

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December 2018
1 Read

Evaluation of the Possible Synergic Regenerative Effects of Platelet-Rich Plasma and Hydroxyapatite/Zirconia in the Rabbit Mandible Defect Model.

Iran J Med Sci 2018 Nov;43(6):633-644

Tissue Engineering Lab, Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Platelet-rich plasma (PRP) and bioceramics such as hydroxyapatite (HA) and zirconium oxide (ZrO) are used to reconstruct mandibular defects. We sought to determine the synergistic effects of HA/ZrO and PRP and compare their osteogenic activity.

Methods: ZrO scaffolds were constructed by the slurry method and were then coated with HA and impregnated by PRP/heparan sulfate (HS). Read More

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November 2018

Assessment of metabolic patterns and new antitumoral treatment in osteosarcoma xenograft models by [F]FDG and sodium [F]fluoride PET.

BMC Cancer 2018 Nov 29;18(1):1193. Epub 2018 Nov 29.

Servicio de Medicina Nuclear, Clínica Universidad de Navarra, Avenida Pío XII, 36 31008, Pamplona, Spain.

Background: Osteosarcoma is the most common malignant bone tumor in children and young adults that produces aberrant osteoid. The aim of this study was to assess the utility of 2-deoxy-2-[18F-] fluoro-D-glucose ([F] FDG) and sodium [F] Fluoride (Na [F] F) PET scans in orthotopic murine models of osteosarcoma to describe the metabolic pattern of the tumors, to detect and diagnose tumors and to evaluate the efficacy of a new treatment based in oncolytic adenoviruses.

Methods: Orthotopic osteosarcoma murine models were created by the injection of 143B and 531MII cell lines. Read More

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November 2018
1 Read

Successful percutaneous treatment of osteoid osteoma in a 13 month-old boy with radiofrequency ablation under CT guidance.

Acta Orthop Traumatol Turc 2018 Nov 13. Epub 2018 Nov 13.

University of Health Sciences, Gaziosmanpasa Training and Research Hospital, Radiology Department, Turkey. Electronic address:

We present a 13-month-old boy who had a successful Computed Tomography (CT) guided percutaneous radiofrequency ablation (RFA) treatment for the osteoid osteoma (OO) on proximal part of the tibial diaphysis. The complaints of the patient were being restless due to pain and refusing to bear any weight on his left leg for 6 months. An asymmetrical cortical thickening and a focal sclerosis was detected on medial proximal diaphysis of the left tibia on radiographs and axial T2-weighted STIR-MR image showed bone marrow and soft-tissue edema with low-signal-intensity nidus due to central calcification with a high-signal-intensified unmineralized periphery. Read More

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November 2018
5 Reads

Estrogen depletion alters mineralization regulation mechanisms in an ovariectomized monkey animal model.

Bone 2018 Nov 7;120:279-284. Epub 2018 Nov 7.

Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Department of Biomedical Engineering, Indiana University-Purdue University, Indianapolis (IUPUI), Indianapolis, IN 46202, USA.

Ovariectomized animal models have been extensively used in osteoporosis research due to the resulting loss of bone mass. The purpose of the present study was to test the hypothesis that estrogen depletion alters mineralization regulation mechanisms in an ovariectomized monkey animal model. To achieve this we used Raman microspectroscopy to analyze humeri from monkeys that were either SHAM-operated or ovariectomized (N = 10 for each group). Read More

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November 2018
1 Read

Radiofrequency ablation of osteoid osteoma: Aiming for excellent outcomes in an Australasian context.

J Med Imaging Radiat Oncol 2018 Dec 8;62(6):789-793. Epub 2018 Nov 8.

Ormiston Orthopaedics, Auckland, New Zealand.

Introduction: To report a series of patients with osteoid osteoma treated by radiofrequency ablation in whom no complications or recurrences occurred.

Methods: Over a 13-year period, 32 consecutive patients with osteoid osteoma were treated by radiofrequency ablation in an Australasian teaching centre.

Results: All patients had resolution of symptoms with no complication or recurrence. Read More

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December 2018
5 Reads

Percutaneous Treatments of Benign Bone Tumors.

Semin Intervent Radiol 2018 Oct 5;35(4):324-332. Epub 2018 Nov 5.

Interventional Imaging, Nouvel Hôpital Civil, 1 place de l'Hôpital, Strasbourg Cedex, France.

Benign bone tumors consist of a wide variety of neoplasms that do not metastasize but can still cause local complications. Historical management of these tumors has included surgical treatment for lesion resection and possible mechanical stabilization. Initial percutaneous ablation techniques were described for osteoid osteoma management. Read More

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October 2018
6 Reads

HIFU for Bone Metastases and other Musculoskeletal Applications.

Semin Intervent Radiol 2018 Oct 5;35(4):261-267. Epub 2018 Nov 5.

Department of Radiological, Oncological and Pathological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

High-intensity focused ultrasound (HIFU) is a totally noninvasive procedure that has shown promising results in the management of numerous malignant and nonmalignant conditions. Under magnetic resonance or ultrasound guidance, high-intensity ultrasound waves are focused on a small, well-defined target region, inducing biologic tissue heating and coagulative necrosis, thus resulting in a precise and localized ablation. This treatment has shown both great safety and efficacy profiles, and may offer a multimodal approach to different diseases, providing pain palliation, potential local tumor control, and, in some cases, remineralization of trabecular bone. Read More

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October 2018
1 Read

Mineralized Polysaccharide Transplantation Modules Supporting Human MSC Conversion into Osteogenic Cells and Osteoid Tissue in a Non-Union Defect.

Mol Cells 2018 11 6. Epub 2018 Nov 6.

Division in Anatomy and Developmental Biology, Department of Oral Biology, Oral Science Research Center, BK.

Regenerative orthopedics needs significant devices to transplant human stem cells into damaged tissue and encourage automatic growth into replacements suitable for the human skeleton. Soft biomaterials have similarities in mechanical, structural and architectural properties to natural extracellular matrix (ECM), but often lack essential ECM molecules and signals. Here we engineer mineralized polysaccharide beads to transform MSCs into osteogenic cells and osteoid tissue for transplantation. Read More

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November 2018
8 Reads

Osteoid osteoma: Contemporary management.

Orthop Rev (Pavia) 2018 Sep 25;10(3):7496. Epub 2018 Sep 25.

Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.

Osteoid osteoma is a benign bone-forming tumor with hallmark of tumor cells directly forming mature bone. Osteoid osteoma accounts for around 5% of all bone tumors and 11% of benign bone tumors with a male predilection. It occurs predominantly in long bones of the appendicular skeleton. Read More

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September 2018
6 Reads

Fibroblast growth factor-23 may serve as a novel biomarker for renal osteodystrophy progression.

Int J Mol Med 2019 Jan 15;43(1):535-546. Epub 2018 Oct 15.

Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.

The purpose of the present study was to determine whether fibroblast growth factor (FGF)‑23 could serve as a novel biomarker for renal osteodystrophy (ROD) progression. A rat model of ROD was induced by left nephrectomy plus intravenous injection of Adriamycin. Serum FGF‑23 was determined using an enzyme‑linked immunosorbent assay. Read More

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January 2019
4 Reads
1.880 Impact Factor

Percutaneous Radiofrequency Ablation of Spinal Osteoid Osteomas Using a Targeted Navigational Bipolar Electrode System.

AJNR Am J Neuroradiol 2018 Dec 25;39(12):2385-2388. Epub 2018 Oct 25.

Mallinckrodt Institute of Radiology (J.W.J.), St. Louis, Missouri.

Safe and effective percutaneous CT-guided radiofrequency ablation of spinal osteoid osteomas can be performed using a targeted navigational bipolar electrode system. Articulating bipolar electrodes with built-in thermocouples along an electrode shaft and variable generator wattage settings allow optimal nidus access, particularly in challenging locations; provide precise real-time monitoring of ablation zone volume and geometry; and minimize the risk of undesired thermal injury. Read More

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December 2018

Primary Osteosarcoma of the Liver: Case Report and Literature Review.

Pathol Oncol Res 2018 Oct 25. Epub 2018 Oct 25.

Department of Pathology, Xi Jing Hospital, 4th Military Medical University, No. 169 Chang Le Xi Road, Xi'an, 710032, Shaanxi, China.

Extraskeletal osteosarcoma is a rare, highly malignant, osteoid formation mesenchymal neoplasm in the absence of bone involvement, associated with exceptionally poor prognosis. It frequently arises in the soft tissues of the extremities or in the retroperitoneum, but rarely in visceral organ. We describe a primary osteosarcoma of the liver in a 70-year-old man who presented with an episode of fever, accompanied by abdominal discomfort, after an accident abdominal strike. Read More

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October 2018
3 Reads

Osteoid Osteoma of the Middle Phalanx of the Third Finger in a Child Mimicking a Malignancy.

Folia Med (Plovdiv) 2018 Jun;60(2):314-317

Department of Cardiology, St. Ekaterina University Hospital, Medical University of Sofia, Sofia, Bulgaria.

Osteoid osteoma is a rare occurrence in the hand, especially in children. We report here a rare case of a 12-year-old boy complaining of growing painful swelling of the middle phalanx of the third finger that had started 3 months earlier and had not responded to anti-inflammatory medication. Based on the clinical findings and plain radiographs, osteomyelitis or Ewing's sarcoma was suspected. Read More

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June 2018
1 Read

Epigallocatechin Gallate-Modified Gelatins with Different Compositions Alter the Quality of Regenerated Bones.

Int J Mol Sci 2018 Oct 19;19(10). Epub 2018 Oct 19.

Department of Orthodontics, Osaka Dental University, 8-1, Kuzuhahanazonocho, Hirakata, Osaka 573-1121, Japan.

Bone quality is a significant indicator of the result of bone treatments. However, information regarding the quality of regenerated bones is limited. The study investigates the effect of different compositions of vacuum heated epigallocatechin gallate-modified gelatins sponge (vhEGCG-GS) on the quality of regenerated bones in critical size defects (9 mm) of rat calvariae. Read More

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October 2018
6 Reads

Osteoid osteoma: multimodality imaging with focus on hybrid imaging.

Eur J Nucl Med Mol Imaging 2018 Oct 19. Epub 2018 Oct 19.

Department of Radiology and Nuclear Medicine, Cantonal Hospital Lucerne, Lucerne, Switzerland.

Osteoid osteoma is a painful, benign, osteoblastic lesion that occurs in younger patients and affects the extremities or the axial skeleton. While plain film findings may suggest the diagnosis, in complex anatomical regions such as the spine, pelvis, wrist and foot advanced imaging modalities are often required. A typical nidus surrounded by sclerosis or cortical thickening characterizes osteoid osteoma on plain radiography and CT. Read More

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October 2018
6 Reads

Subclassification of pleomorphic sarcomas: How and why should we care?

Authors:
Jason L Hornick

Ann Diagn Pathol 2018 Oct 11;37:118-124. Epub 2018 Oct 11.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:

Pleomorphic sarcomas are a heterogeneous group of mesenchymal neoplasms with widely varied clinical behavior but overlapping histologic appearances. The following guidelines are helpful when approaching the diagnosis of a pleomorphic sarcoma. (1) Be aware of the relative incidence of the various sarcoma types: several pleomorphic sarcomas are relatively common (e. Read More

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October 2018
4 Reads

HER-2 Immunohistochemical Expression in Bone Sarcomas: A New Hope for Osteosarcoma Patients.

Open Access Maced J Med Sci 2018 Sep 4;6(9):1555-1560. Epub 2018 Sep 4.

Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background: Osteosarcoma and chondrosarcoma, remain the most common primary bone tumours. Questions have been raised about the prognostic influence of HER-2 in bone sarcomas, but so far the results have been debatable. The her-2 expression is possibly a predictor of chemotherapy response. Read More

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September 2018

Primary Extraskeletal Osteosarcoma Arising from the Optic Nerve: A Rare Case Report.

Ocul Oncol Pathol 2018 Sep 14;4(5):304-308. Epub 2018 Feb 14.

Department of Pathology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, India.

Orbital location of extraskeletal osteosarcoma is extremely rare with only 4 cases reported so far in the English literature. We present the case of a 32-year-old female who presented with proptosis and complete loss of vision of the left eye. Contrast-enhanced computed tomography scan showed a densely calcified lobulated lesion in the left optic nerve showing strong enhancement. Read More

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September 2018
1 Read

Fibro-osseous pseudotumor of the digit: Case report and surgical experience with extensive digital lesion abutting on neurovascular bundles.

Ann Med Surg (Lond) 2018 Nov 4;35:158-162. Epub 2018 Oct 4.

Plastic and Reconstructive Surgery, Surgery Department, King Fahad National Guard Hospital, King Abdulaziz Medical City (KAMC), Saudi Arabia.

Background: Fibro-osseous pseudotumor (FOPD) of the digit is a rare benign lesion of subcutaneous tissue characterized by fibroblastic proliferation and osteoid formation. Herein, we present a case of massive FOPD lesion in the base of ring finger with extensive involvement of the neurovascular bundles with challenging surgical approach.

Case Description: A 27-year old female patient, presented with 7-months history of a progressively enlarging mass on her left hand. Read More

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November 2018
7 Reads

Transsphenoidal Removal of Recurrent Osteoid Osteoma of Clivus.

World Neurosurg 2018 Dec 26;120:506-508. Epub 2018 Sep 26.

Department of Neurosurgery, University of Tuebingen, Tuebingen, Germany.

Background: An osteoid osteoma (OO) is a benign bone neoplasm that typically occurs in the long bone diaphysis. We found only 8 cases of OOs of the skull base in the literature, and none of them were located in the clivus.

Case Description: A 44-year-old female patient with a history of 2 previous transsphenoidal surgeries with partial removal of an OO of the clivus at another hospital, 11 and 4 years ago, presented to our department with recurrent progressive left-sided headache and facial pain over the past 6 months, which were aggravated at night. Read More

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December 2018
6 Reads

Arthroscopic Excision of Osteoid Osteoma of the Femoral Neck.

Indian J Orthop 2018 Sep-Oct;52(5):568-571

Department of Orthopaedics, MMCRI, Mysore, Karnataka, India.

Osteoid osteoma (OO) is a benign, solitary bone tumor of the long bones of the lower limbs and accounts for 10% to 12% of all benign bone. However, an OO of the femoral neck is extremely rare and difficult to treat. Arthroscopic excision of OO of the femoral neck has many advantages. Read More

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September 2018

Osteoid osteoma treated with radiofrequency ablation in non-operating room anesthesia. A different way of approaching ablative therapy on osteoid osteoma.

Eur Rev Med Pharmacol Sci 2018 Sep;22(17):5438-5446

Diagnostic Imaging Area, Catholic University of the Sacred Heart, Gemelli Foundation, School of Medicine, Rome, Italy.

Objective: The purpose of this study is to verify the effectiveness and complications occurrence of radiofrequency ablation (RFA) in the treatment of osteoid osteoma (OO) in non-operating room anesthesia (N.O.R. Read More

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September 2018

Targetability of osteoid osteomas and bone metastases by MR-guided high intensity focused ultrasound (MRgHIFU).

Int J Hyperthermia 2018 Sep 13:1-9. Epub 2018 Sep 13.

b ICube , University of Strasbourg , Strasbourg , France.

Purpose: To retrospectively evaluate the suitability of MRgHIFU for osteoid osteomas (OOs) and bone metastases in patients who underwent minimally-invasive percutaneous thermal ablation.

Materials And Methods: One hundred and sixty-seven lesions (115 metastases and 52 OOs) treated percutaneously between October 2014 and June 2017 were retrospectively analyzed. Tumors were located in the spine or sacrum (54), pelvis (43), limbs (50), ribs (17) and sternum (3). Read More

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September 2018

Malignant Tenosynovial Giant Cell Tumor: The True "Synovial Sarcoma?" A Clinicopathologic, Immunohistochemical, and Molecular Cytogenetic Study of 10 Cases, Supporting Origin from Synoviocytes.

Mod Pathol 2018 Sep 11. Epub 2018 Sep 11.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

We present our experience with ten well-characterized malignant tenosynovial giant cell tumors, including detailed immunohistochemical analysis of all cases and molecular cytogenetic study for CSF1 rearrangement in a subset. Cases occurred in 7 M and 3 F (mean age: 52 years; range: 26-72 years), and involved the ankle/foot (n = 1), finger/toe (n = 3), wrist (n = 1), pelvic region (n = 3), leg (n = 1), and thigh (n = 1). There were eight primary and two secondary malignant tenosynovial giant cell tumors. Read More

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September 2018
6 Reads

Periostin expression in neoplastic and non-neoplastic diseases of bone and joint.

Clin Sarcoma Res 2018 5;8:18. Epub 2018 Sep 5.

1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal and Sciences, Nuffield Orthopaedic Centre, University of Oxford, Oxford, OX3 7HE UK.

Background: Periostin is a matricellular protein that is expressed in bone and joint tissues. To determine the expression of periostin in primary bone tumours and to assess whether it plays a role in tumour progression, we carried out immunohistochemistry and ELISA for periostin in a range of neoplastic and non-neoplastic bone and joint lesions.

Methods: 140 formalin-fixed paraffin-embedded sections of bone tumours and tumour-like lesions were stained by an indirect immunoperoxidase technique with a polyclonal anti-periostin antibody. Read More

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September 2018
4 Reads

Fin healing and regeneration in sturgeon.

J Fish Biol 2018 Nov;93(5):917-930

Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi.

Pectoral fin healing in fin spines and rays were examined in juvenile Atlantic sturgeon Acipenser oxyrinchus oxyrinchus following three different sampling techniques (n = 8-9 fish per treatment): entire leading fin spine removed, a 1-2 cm portion removed near the point of articulation, or a 1-2 cm portion removed from a secondary fin ray. Also, to determine whether antibiotic treatment influences healing, an additional group of fish (n = 8) was not given an injection of an oxytetracycline (OTC)-based antibiotic following removal of the entire leading fin spine. Following fin sampling, fish from different treatments were mixed equally between three large (4,000 I) recirculating systems and fin-ray healing and mortality were monitored over a 12 month period. Read More

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November 2018
2 Reads

A rare case of giant osteoblastoma of the sacrum.

Orthopade 2018 Sep 7. Epub 2018 Sep 7.

Department of Orthopedics, Artificial Joints Engineering and Technology Research Center of Jiangxi Province and Multidisciplinary Therapy Center of Musculoskeletal Tumor, The First Affiliated Hospital of Nanchang University, 330006, Nangchang, Jiangxi, China.

Background: An osteoblastoma is a rare benign bone tumor characterized by formation of osteoid tissue and primitive bone and occurs more often in men than in women. They are often secondary to an osteoid osteoma and can be located at any site on the skeleton. Lesions generally involve the posterior elements of the spine, such as the pedicle and the lamina. Read More

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September 2018
9 Reads

Dynamic structure and composition of bone investigated by nanoscale infrared spectroscopy.

PLoS One 2018 4;13(9):e0202833. Epub 2018 Sep 4.

Hospital for Special Surgery, Research Institute, New York, New York, United States of America.

Bone is a highly organized tissue in which each structural level influences the macroscopic and microscopic mechanical behavior. In particular, the quantity, quality, and distribution of the different bone components, i.e. Read More

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September 2018
6 Reads
3.234 Impact Factor

Application of donepezil increased collagen 1 expression in mesenchymal stroma cells of an ovine osteoporosis model.

J Musculoskelet Neuronal Interact 2018 Sep;18(3):354-365

Experimental Trauma Surgery, Justus-Liebig-University Giessen, Germany.

Objectives: Donepezil inhibits the acetylcholine degradation molecule acetylcholinesterase (AChE). Clinical studies reported that Alzheimer's disease (AD) patients with hip fractures had improved bone quality and better fracture healing if they were treated with AD medication donepezil. We asked whether mesenchymal stroma cells (MSC) from an osteoporosis sheep model treated with donepezil increased their proliferation rate and mRNA expression. Read More

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September 2018
5 Reads
2.400 Impact Factor

Cystic Degeneration of Craniofacial Fibrous Dysplasia.

World Neurosurg 2018 Dec 31;120:159-162. Epub 2018 Aug 31.

Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Erasmus Medical Center and Sophia Children's Hospital, Rotterdam, The Netherlands.

Background: Fibrous dysplasia (FD) is most often a slowly progressive benign disease in which the normal bone structure is replaced by fibrous and osteoid tissue.

Case Description: A 16-year-old adolescent, known with FD in the sphenoid bone, suffered an acute decreased visual acuity with papilledema on the left eye. The radiologic images were best compatible with cystic degeneration of the known FD with optic nerve compression in the optic canal. Read More

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December 2018
7 Reads

Restoration of mandibular bone defects with demineralized bone matrix combined with three-dimensional cultured bone marrow-derived mesenchymal stem cells in minipig models.

J Mater Sci Mater Med 2018 Aug 31;29(9):147. Epub 2018 Aug 31.

Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100080, China.

Mandibular defects, caused by congenital, pathological or iatrogenic insults, can significantly affect patient quality of life. The reconstruction of mandible has recently gained the interest of clinical and tissue engineering researchers. The purpose of this study was to evaluate the effectiveness of three-dimensional (3-D) cultured autologous grafts prepared using bone marrow-derived mesenchymal stem cells (BMSCs) combined with demineralized bone matrix (DBM) scaffolds for the restoration of mandibular defects. Read More

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August 2018
1 Read

Osseointegrative effect of rhBMP-2 covalently bound on a titan-plasma-spray-surface after modification with chromosulfuric acid in a large animal bone gap-healing model with the Göttingen minipig.

J Orthop Surg Res 2018 Aug 30;13(1):219. Epub 2018 Aug 30.

Department for Experimental Orthopaedics and Trauma Surgery, Orthopaedic and Trauma Surgery Centre (OUZ), University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Background: Bone morphogenetic proteins play an important role as osseointegrative factors. It is used widely in orthopedic research and surgery to enhance the osseointegrative potential of implants, e.g. Read More

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August 2018
1 Read

The Effects of Vitamin E from (Oil Palm) in a Rat Model of Bone Loss Due to Metabolic Syndrome.

Int J Environ Res Public Health 2018 08 24;15(9). Epub 2018 Aug 24.

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaakob Latif, Bandar Tun Razak, Cheras 56000, Kuala Lumpur, Malaysia.

The beneficial effects of vitamin E in improving components of MetS or bone loss have been established. This study aimed to investigate the potential of palm vitamin E (PVE) as a single agent, targeting MetS and bone loss concurrently, using a MetS animal model. Twelve-week-old male Wistar rats were divided into five groups. Read More

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August 2018
8 Reads

Distinct Clinical and Pathological Features of Melorheostosis Associated With Somatic MAP2K1 Mutations.

J Bone Miner Res 2018 Aug 23. Epub 2018 Aug 23.

Clinical and Investigative Orthopedics Surgery Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.

Melorheostosis is a rare hyperostotic disease of the long bones classically characterized by a "dripping candle-wax" radiographic appearance. We recently described somatic activating mutations in MAP2K1 as a cause of melorheostosis. Here, we report distinguishing characteristics of patients with MAP2K1-positive melorheostosis. Read More

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August 2018
17 Reads
6.830 Impact Factor

Pediatric Benign Paranasal Sinus Osteoneogenic Tumors: A Case Series and Systematic Review of Outcomes, Techniques, and a Multiportal Approach.

Am J Rhinol Allergy 2018 Nov 22;32(6):465-472. Epub 2018 Aug 22.

3 Rick and Tina Caruso Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California.

Background: Pediatric benign paranasal sinus osteoneogenic tumors have previously been difficult to treat due to the surgical constraints of the developing skull. Progression may lead to intracranial complications or orbital and optic nerve compression.

Objective: To assess the presentation and management of benign paranasal sinus osteoneogenic tumors. Read More

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November 2018
9 Reads

[Bone marrow edema-differential diagnosis of the femoral head necrosis].

Authors:
P Stumpp A Roth

Orthopade 2018 Sep;47(9):717-721

Klinik und Poliklinik für Orthopädie, Unfallchirurgie und Plastische Chirurgie Bereich Endoprothetik/Orthopädie, Universitätsklinik Leipzig AöR, Leipzig, Deutschland.

In patients with hip pain, clinical examination is of only restricted value in the differential diagnosis. Besides a patient's age, their medical history is often helpful in finding the correct diagnosis. Additionally, imaging can give valuable hints for excluding or validating a differential diagnosis. Read More

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September 2018
1 Read

Expression of Noncollagenous Bone Matrix Proteins in Osteoblasts Stimulated by Mechanical Stretching in the Cranial Suture of Neonatal Mice.

J Histochem Cytochem 2018 Aug 16:22155418793588. Epub 2018 Aug 16.

Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

We investigated the influence of mechanical stretching on the genetic expression pattern of noncollagenous bone matrix proteins in osteoblasts. The cranial sutures of neonatal mice were subjected to ex vivo mechanical stretching. In the nonstretched control group, as osteoblast differentiation progressed, the successive genetic expression of bone sialoprotein (BSP), osteopontin (OPN), and osteocalcin (OCN) was detected using in situ hybridization, in that order. Read More

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Imaging features and differential diagnosis of multiple diaphyseal sclerosis: A case report and review of literature.

Medicine (Baltimore) 2018 Aug;97(33):e11725

Department of Spine Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.

Rationale: Multiple diaphyseal sclerosis (MDS), known as Ribbing disease, is a rare congenital bone disease resulting from autosomal recessive inheritance. The case study involved a 22-year-old female patient who had been diagnosed with chronic sclerosing osteomyelitis due to lack of knowledge about MDS. Previous studies reported rarely on this condition. Read More

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August 2018
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Phase I clinical trial of percutaneous cryoablation for osteoid osteoma.

Jpn J Radiol 2018 Nov 14;36(11):669-675. Epub 2018 Aug 14.

Department of Interventional Radiology and Clinical Ultrasound Center, Gunma University Hospital, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Purpose: This prospective phase I trial was conducted to evaluate the safety of percutaneous cryoablation for osteoid osteoma (OO).

Materials And Methods: Nine patients with OO (mean tumor size: 5.9 mm; tibia, n = 5; femur, n = 2; lumbar spine, n = 2) were enrolled and treated with percutaneous cryoablation. Read More

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November 2018
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Histologic and Histomorphometric Analysis of Bone Regeneration with Bovine Grafting Material after 24 Months of Healing. A Case Report.

J Funct Biomater 2018 Aug 8;9(3). Epub 2018 Aug 8.

Department of Dental and Maxillofacial Sciences, School of Dentistry, University La Sapienza, 00100 Rome, Italy.

Anorganic bovine bone mineral matrix (ABBMM) has been reported to have osteoconductive properties and no inflammatory or adverse responses when used as grafting material in sinus augmentation procedures. However, controversy remains in regard to degradation rate of ABBMM. The aim of this study was to histologically and histomorphometrically evaluate the degradation of ABBMM in human bone samples obtained in one patient 24 months after sinus augmentation. Read More

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The Effect of Bone Marrow Mesenchymal Stem Cells Application on Distracted Bone Quality during Rapid Rate of Distraction Osteogenesis.

Craniomaxillofac Trauma Reconstr 2018 Sep 19;11(3):192-198. Epub 2017 Jul 19.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.

Distraction osteogenesis (DO) bone regenerate usually suffers from an inferior quality especially with rapid rate. This study was conducted to investigate the effect of mesenchymal stem cells (MSCs) application on different rates of distraction bone quality. Twenty-four goats were divided into group A with standard DO and group B with rapid distraction osteogenesis (RDO) both aided by MSCs. Read More

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September 2018