187 results match your criteria Osteofibrous Dysplasia


Osteofibrous dysplasia arising in the humerus: A case report.

Rare Tumors 2018 5;10:2036361318808852. Epub 2018 Nov 5.

Department of Pathology, Tohoku University Hospital, Sendai, Japan.

Osteofibrous dysplasia is a benign fibro-osseous lesion of bone which is most commonly occurred in cortical bone of anterior mid-shaft of the tibia of infancy and childhood. This study reported a case of osteofibrous dysplasia arising in the humerus of adult, resulting in good prognosis after a surgical treatment. A 34-year-old male had felt left upper arm pain and was suspected as having a bone tumor at the humeral shaft by X-ray pictures. Read More

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http://dx.doi.org/10.1177/2036361318808852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236643PMC
November 2018
10 Reads

Giant monostotic osteofibrous dysplasia of the ilium: A case report and review of literature.

World J Clin Cases 2018 Nov;6(14):830-835

Department of Orthopedics, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, Jiangsu Province, China.

Background: Osteofibrous dysplasia (OFD) is a developmental skeletal disorder, and cases with a giant affected area in the pelvis are rare.

Case Summary: In this case report, a 48-year-old man presented with a large tumor in the right iliac region that turned out to be OFD. The patient had rebound tenderness in his right hip. Read More

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http://dx.doi.org/10.12998/wjcc.v6.i14.830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264999PMC
November 2018
2 Reads

Extraperiosteal segmental excision for osteofibrous dysplasia of tibia with reconstruction by liquid nitrogen-treated recycled autograft.

J Orthop Sci 2019 Mar 30;24(2):342-346. Epub 2018 Oct 30.

Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China. Electronic address:

Background: Osteofibrous dysplasia usually progresses until ten years of age and occasionally regresses spontaneously after puberty. Patients with osteofibrous dysplasia usually require close observation. Surgery is an option considered only for extensive, deforming lesions and those with pathological fractures and rapid progression prior to puberty. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09492658183029
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http://dx.doi.org/10.1016/j.jos.2018.10.004DOI Listing
March 2019
8 Reads
1.010 Impact Factor

Adamantinoma of bone: Long-term follow-up of 46 consecutive patients.

J Surg Oncol 2018 Dec 17;118(7):1150-1154. Epub 2018 Oct 17.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.

Background: Adamantinomas are rare bone tumors, commonly affecting the tibia. Due to the rare nature of disease, previous studies are small or from multiple centers. The purpose of this study is to investigate outcomes of patients with adamantinoma treated in a single institution. Read More

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http://doi.wiley.com/10.1002/jso.25269
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http://dx.doi.org/10.1002/jso.25269DOI Listing
December 2018
9 Reads

Periostin expression in neoplastic and non-neoplastic diseases of bone and joint.

Clin Sarcoma Res 2018 5;8:18. Epub 2018 Sep 5.

1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal and Sciences, Nuffield Orthopaedic Centre, University of Oxford, Oxford, OX3 7HE UK.

Background: Periostin is a matricellular protein that is expressed in bone and joint tissues. To determine the expression of periostin in primary bone tumours and to assess whether it plays a role in tumour progression, we carried out immunohistochemistry and ELISA for periostin in a range of neoplastic and non-neoplastic bone and joint lesions.

Methods: 140 formalin-fixed paraffin-embedded sections of bone tumours and tumour-like lesions were stained by an indirect immunoperoxidase technique with a polyclonal anti-periostin antibody. Read More

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http://dx.doi.org/10.1186/s13569-018-0105-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123976PMC
September 2018
8 Reads

Osteofibrous Dysplasia with Rhabdoid Elements in a 38-Year-Old Man with Spontaneous Regression Over Five Years: A Case Report.

JBJS Case Connect 2018 Jul-Sep;8(3):e51

Department of Radiology, Universitaetsklinik Balgrist, Zurich, Switzerland.

Case: A 38-year-old man presented with multifocal, partially confluent osteolytic lesions in the proximal dia-meta-epiphyseal region of the proximal aspect of the left tibia, which had been found incidentally when a radiograph was made after a rotational knee injury. When the results of a percutaneous core needle biopsy proved inconclusive, an open biopsy was performed. Osteofibrous dysplasia (OFD) with scattered groups of plump cells with a rhabdoid phenotype, shown to express both vimentin and pan-cytokeratin, was found. Read More

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http://Insights.ovid.com/crossref?an=01709767-201809000-0000
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http://dx.doi.org/10.2106/JBJS.CC.17.00294DOI Listing
July 2018
3 Reads

Optimal Treatment of Osteofibrous Dysplasia of the Tibia.

J Pediatr Orthop 2018 Aug;38(7):e404-e410

Department of Orthopaedic Surgery, Seoul National University Hospital.

Background: Our study of a large patient group reports on the behavior and postoperative recurrence of osteofibrous dysplasia (OFD).

Methods: We reviewed the medical records of 55 patients who were diagnosed with OFD of the tibia and showed typical features of this tumor. The patients' presentation, disease course, history of pathologic fracture, typical radiographic features, surgical treatment history, and surgical results were investigated. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001197DOI Listing
August 2018
3 Reads

Paediatric osteofibrous dysplasia-like adamantinoma with classical radiological findings.

BMJ Case Rep 2018 May 15;2018. Epub 2018 May 15.

Department of Radiology, Alder Hey NHS Foundation Trust, Liverpool, UK.

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http://dx.doi.org/10.1136/bcr-2018-224487DOI Listing
May 2018
4 Reads

Osteofibrous Dysplasia of the Tibia in Children: Outcome Without Resection.

J Pediatr Orthop 2017 Dec 8. Epub 2017 Dec 8.

The Hospital for Sick Children, Toronto, ON, Canada.

Background: The proposed association between osteofibrous dysplasia and adamantinoma has led some to advocate resection of the entire lesion, which can require major subsequent reconstruction. However, this link remains unproven and there is some support in more recent literature for a less aggressive approach. This study aims to describe our experience managing pediatric tibial osteofibrous dysplasia with such an approach and to report functional outcomes in children treated thus. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001116DOI Listing
December 2017
5 Reads

Modified technique for preservation of inferior alveolar nerve during mandibulectomy.

Head Neck 2017 12 30;39(12):2562-2566. Epub 2017 Sep 30.

Department of Oral Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China.

Background: The purpose of this article is to introduce the modified technique of preservation of the inferior alveolar nerve (IAN) during mandibulectomy for a benign lesion.

Methods: Five cases of osteofibrous hyperplasia and 3 cases of centricity osteomyelitis were included. During surgery, the IAN was marked using a planned cutting guide. Read More

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http://dx.doi.org/10.1002/hed.24924DOI Listing
December 2017
13 Reads

Bilateral Tibial Osteofibrous Dysplasia on 18F-FDG PET/CT.

Clin Nucl Med 2017 Aug;42(8):e375-e376

From the Departments of *Radiology, and †Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

A 17-year-old girl had pain in the right front lower leg while road racing 2 months earlier. Radiography and CT showed osteolytic lesions in the medial part of the bilateral tibia. Bone scintigraphy showed focally increased radiotracer uptake in the bilateral tibia. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9803
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http://dx.doi.org/10.1097/RLU.0000000000001702DOI Listing
August 2017
21 Reads

Does osteofibrous dysplasia progress to adamantinoma and how should they be treated?

Bone Joint J 2017 Mar;99-B(3):409-416

Royal Orthopaedic Hospital, Birmingham, UK.

Aims: The aim of this study was to identify any progression between benign osteofibrous dysplasia (OFD), OFD-like adamantinoma and malignant adamantinoma, and to investigate the rates of local recurrence, metastases and survival, in order to develop treatment algorithms for each.

Patients And Methods: A single institution retrospective review of all patients presenting with OFD, OFD-like adamantinoma and adamantinoma between 1973 and 2012 was undertaken. Complete data were available for 73 patients (42 with OFD; ten with an OFD-like adamantinoma and 21 with an adamantinoma). Read More

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http://dx.doi.org/10.1302/0301-620X.99B3.38050DOI Listing
March 2017
1 Read

Osteofibrous Dysplasia Versus Ossifying Fibroma: Semantic Confusion.

J Oral Maxillofac Surg 2017 05 24;75(5):885. Epub 2017 Feb 24.

Saitama, Japan.

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http://dx.doi.org/10.1016/j.joms.2017.01.026DOI Listing
May 2017
4 Reads

Management of Large Maxillomandibular Osteofibrous Dysplasia as Part of a Humanitarian Mission.

J Oral Maxillofac Surg 2017 Feb 18;75(2):436.e1-436.e10. Epub 2016 Oct 18.

Maxillofacial Surgeon, Professor and Department Head, Department of Maxillofacial and Plastic Surgery, Caen University Hospital, Caen; UNICAEN, EA4652 Equipe BioConnecT, Caen; Medicine Faculty of Caen, University of Caen Basse Normandie, Caen, France.

Purpose: Maxillomandibular ossifying fibroma is a benign tumor that affects young adults. Complete excision can allow satisfactory management with no recurrence. During a humanitarian mission, one is confronted with many types of damage from these fibromas. Read More

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http://dx.doi.org/10.1016/j.joms.2016.10.006DOI Listing
February 2017
6 Reads

Long-term outcome following treatment of Adamantinoma and Osteofibrous dysplasia of long bones.

Orthop Traumatol Surg Res 2016 11 10;102(7):925-932. Epub 2016 Oct 10.

Department of Orthopedics, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

Introduction: Adamantinoma (AD) is an ultimately rare, low-grade malignant bone tumor. In most cases it occurs in the tibia of young adults. Osteofibrous dysplasia (OFD) is a rare, benign, lesion that is typically seen in children. Read More

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http://dx.doi.org/10.1016/j.otsr.2016.08.010DOI Listing
November 2016
1 Read

[Osteofibrous dysplasia of metacarpus: a case report].

Zhongguo Gu Shang 2016 Jun;29(6):570-2

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June 2016
1 Read

Osteofibrous dysplasia of clavicle clinically mimicking chronic osteomyelitis.

Indian J Radiol Imaging 2016 Apr-Jun;26(2):290-3

Department of Pathology, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab and Haryana, India.

Osteofibrous dysplasia or ossifying fibroma is an uncommon benign fibro-osseous lesion of childhood, commonly described in the maxilla and the mandible. Among long bones, it usually presents in the tibia as a painless swelling or anterior bowing. Ossifying fibroma of clavicle has never been reported in English literature, to the best of our knowledge. Read More

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http://dx.doi.org/10.4103/0971-3026.184411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931793PMC
July 2016
1 Read

[Tumor-like lesions of bone].

Authors:
R Erlemann G Jundt

Radiologe 2016 Jun;56(6):507-19

Knochentumorreferenzzentrum am Institut für Pathologie, Universitätsspital, Basel, Schweiz.

Historically, tumor-like lesions of bone were defined as non-neoplastic bone lesions. Today, however, some of them are considered real neoplasms. They are among the most frequent bone lesions. Read More

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http://dx.doi.org/10.1007/s00117-016-0113-yDOI Listing
June 2016
4 Reads

Sclerostin expression in bone tumours and tumour-like lesions.

Histopathology 2016 Sep 8;69(3):470-8. Epub 2016 Apr 8.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Oxford, UK.

Aims: To assess the immunophenotypic and mRNA expression of sclerostin in human skeletal tissues and in a wide range of benign and malignant bone tumours and tumour-like lesions.

Methods And Results: Sclerostin expression was evaluated by immunohistochemistry and quantitative polymerase chain reaction (PCR). In lamellar and woven bone, there was strong sclerostin expression by osteocytes. Read More

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http://dx.doi.org/10.1111/his.12953DOI Listing
September 2016
7 Reads

Chondroblastic osteosarcoma secondary to fibrosarcoma: A case report and literature review.

Oncol Lett 2015 Dec 12;10(6):3573-3576. Epub 2015 Oct 12.

Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

Osteosarcoma, which is most common in non-blood systemic tumors, accounts for 20% of primary bone malignancies. Primary osteosarcoma usually occurs in young individuals aged 10-20 years, while secondary osteosarcoma is more common in the elderly. It had been reported that secondary osteosarcoma may be associated with osteofibrous dysplasia, bone infarction, chondrosarcoma or osteogenesis imperfecta. Read More

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http://dx.doi.org/10.3892/ol.2015.3792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665868PMC
December 2015
37 Reads

Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia.

Am J Hum Genet 2015 Dec;97(6):837-47

Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.

The periosteum contributes to bone repair and maintenance of cortical bone mass. In contrast to the understanding of bone development within the epiphyseal growth plate, factors that regulate periosteal osteogenesis have not been studied as intensively. Osteofibrous dysplasia (OFD) is a congenital disorder of osteogenesis and is typically sporadic and characterized by radiolucent lesions affecting the cortical bone immediately under the periosteum of the tibia and fibula. Read More

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http://www.cell.com/ajhg/pdf/S0002-9297(15)00446-2.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S000292971500446
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http://dx.doi.org/10.1016/j.ajhg.2015.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678433PMC
December 2015
40 Reads

A rare case of pure primary hemangioma of the scapula: A case report.

Oncol Lett 2015 Oct 12;10(4):2265-2268. Epub 2015 Aug 12.

Multidisciplinary Therapy Center of Musculoskeletal Tumor, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Hemangioma is a benign vascular tumor, which may occur in any bone of the body. The most common locations are the spine and craniofacial bone; however, occurrence is extremely rare in the scapula. The current study presented the case of a 58-year-old female, with scapula hemangioma in the left shoulder who presented with joint ache that had lasted for ~1 year. Read More

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http://dx.doi.org/10.3892/ol.2015.3596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579900PMC
October 2015
2 Reads

Autologous mesenchymal stem cell (MSCs) transplantation for critical-sized bone defect following a wide excision of osteofibrous dysplasia.

Int J Surg Case Rep 2015 5;17:106-11. Epub 2015 Nov 5.

Department of Orthopaedic and Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jl. Dipenogoro No. 71, Salemba, Jakarta Pusat 10430, Indonesia.

Introduction: Osteofibrous dysplasia is a rare non-neoplastic disease that is almost exclusive to pediatric tibial diaphysis. Wide excision of the lesion is recommended to avoid recurrence. However, such radical surgery will results in large segmental bone defects that will require further extensive reconstructive surgery. Read More

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http://dx.doi.org/10.1016/j.ijscr.2015.10.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701811PMC
January 2016
14 Reads

Osteofibrous Dysplasia-like Adamantinoma of the Tibia in a 15-Year-Old Girl.

Am J Orthop (Belle Mead NJ) 2015 Oct;44(10):E411-3

Department of Orthopedics, Texas Tech University Health Sciences Center, Lubbock, TX.

Osteofibrous dysplasia and adamantinoma are rare lesions of primary benign and malignant bone tumors with an incidence of less than 1%. These lesions arise primarily in long bones with a predilection for the tibia and fibula. Osteofibrous dysplasia is a benign fibro-osseous lesion typically found in children younger than 10 years. Read More

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http://jpatholtm.org/upload/pdf/kjp-38-1-50.pdf
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October 2015
3 Reads

Bone Transport for Reconstruction in Benign Bone Tumors.

Clin Orthop Surg 2015 Jun 18;7(2):248-53. Epub 2015 May 18.

Department of Orthopaedic Surgery, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.

Background: The aim of this study was to assess the results of using the Ilizarov apparatus to transport bones in the treatment of benign bone tumors.

Methods: Seven patients (six males and one female) with benign bone tumors were treated by bone transport with an Ilizarov apparatus at our institution. Their mean age at surgery was 14. Read More

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http://synapse.koreamed.org/Synapse/Data/PDFData/0157CIOS/ci
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http://synapse.koreamed.org/DOIx.php?id=10.4055/cios.2015.7.
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http://dx.doi.org/10.4055/cios.2015.7.2.248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515467PMC
June 2015
17 Reads

Osteofibrous dysplasia-like adamantinoma in a 3-month-old male infant: a case report.

Acta Orthop Traumatol Turc 2015 ;49(2):210-2

Memorial Hospital, Department of Orthopedics and Traumatology, İstanbul, Turkey.

We report a case of a very rarely seen osteofibrous dysplasia-like adamantinoma (OFDLA) of the lower leg in a 3-month-old male infant, making it the youngest case in the literature. OFDLA is typically regarded as a benign lesion; however, due to its convertibility into classical adamantinoma, it is recommended to evaluate it as a pre-malignant lesion. After OFDLA diagnosis with biopsy, our case underwent surgical resection and reconstruction with a large allograft. Read More

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http://www.aott.org.tr/index.php/aott/article/view/3068/3852
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http://dx.doi.org/10.3944/AOTT.2015.2809DOI Listing
February 2016
8 Reads

Osteofibrous Dysplasia managed with Extraperiosteal excision, Autologous free fibular graft and bone graft substitute.

J Orthop Case Rep 2015 Jan-Mar;5(1):41-4

Department of Orthopaedics, Mahatma Gandhi Medical College and Research Institute. Sri Balaji Vidyapeeth University, Pondicherry. India.

Introduction: Osteofibrous Dysplasia is a rare benign self-limiting fibro-osseous lesion most commonly seen in the diaphysis of the tibia. Its incidence is reported to be 0.2% of all primary bone tumors. Read More

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http://dx.doi.org/10.13107/jocr.2250-0685.252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719351PMC
June 2016
3 Reads

[Osteolytic diaphyseal tibial lesion with increasing constant dull tibial pain].

Radiologe 2015 Jan;55(1):53-8

Abt. für Diagnostische und Interventionelle Radiologie, Radiologische Klinik, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Deutschland,

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http://dx.doi.org/10.1007/s00117-014-2769-5DOI Listing
January 2015
1 Read

Role of apparent diffusion coefficients with diffusion-weighted magnetic resonance imaging in differentiating between benign and malignant bone tumors.

World J Surg Oncol 2014 Nov 29;12:365. Epub 2014 Nov 29.

Department of Radiology, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai 200092, China.

Background: Benign and malignant bone tumors can present similar imaging features. This study aims to evaluate the significance of apparent diffusion coefficients (ADC) in differentiating between benign and malignant bone tumors.

Methods: A total of 187 patients with 198 bone masses underwent diffusion-weighted (DW) magnetic resonance (MR) imaging. Read More

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http://dx.doi.org/10.1186/1477-7819-12-365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265400PMC
November 2014
14 Reads

Benign bone tumors.

Authors:
Robert Steffner

Cancer Treat Res 2014 ;162:31-63

Orthopaedic Oncology, UC Davis Comprehensive Cancer Center, Sacramento, CA, USA,

Benign bone lesions are a broad category that demonstrates a spectrum of activities from latent to aggressive. Differentiating the various tumors is important in order to properly determine necessary intervention. This chapter focuses on the presentation, imaging, diagnostic features, and treatment of the most common benign bone tumors in order to help guide diagnosis and management. Read More

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http://dx.doi.org/10.1007/978-3-319-07323-1_3DOI Listing
September 2014
8 Reads

[Delayed lower extremity deep venous thrombosis after operation for osteofibrous dysplasia of the left femur: report of one case].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2014 May;43(3):379-81

IDepartment of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou 310012, China.

Lower extremity deep venous thrombosis (LDVT) is one of the most common complications in orthopedic surgery, and it often occurs in the first 24 h after operation. We report a case of delayed LDVT, which occurred on d 16 after operation for osteofibrous dysplasia on the left femur. Upon the diagnosis confirmed, thrombolysis and anticoagulation therapy was conducted. Read More

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May 2014
1 Read

Proliferative, reparative, and reactive benign bone lesions that may be confused diagnostically with true osseous neoplasms.

Semin Diagn Pathol 2014 Jan 25;31(1):66-88. Epub 2013 Dec 25.

Department of Pathology, University of Washington Medical Center, Seattle, Washington.

Diagnostic problems attending intraosseous and parosteal pseudoneoplastic lesions can be radiographic, or histological, or both. Proliferations in this category may contain cellular fibro-osseous or chondro-osseous tissues that are difficult to separate microscopically from those seen in various true neoplasms of the bones. This review considers the clinicopathologic features of fibrous dysplasia, benign fibro-osseous lesions of the jawbones, osteofibrous dysplasia, metaphyseal fibrous defect, giant-cell reparative granuloma, "brown tumor" of hyperparathyroidism, synovial chondrometaplasia, aneurysmal bone cyst, tumefactive chronic osteomyelitis, proliferative Paget disease, and polyvinylpyrrolidone storage disease of bone. Read More

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https://www.researchgate.net/publication/51221182_Reactive_b
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https://linkinghub.elsevier.com/retrieve/pii/S07402570130007
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http://dx.doi.org/10.1053/j.semdp.2013.12.002DOI Listing
January 2014
4 Reads

Activating GNAS mutations in parosteal osteosarcoma.

Am J Surg Pathol 2014 Mar;38(3):402-9

Departments of *Laboratory Medicine and Pathology †Radiology, Mayo Clinic, Rochester, MN.

Parosteal osteosarcoma is a surface-based osteosarcoma that often exhibits deceptively bland cytologic features, hindering diagnosis in small biopsies or when correlative radiologic imaging is not readily available. A number of benign and malignant fibro-osseous lesions, including fibrous dysplasia (FD) and low-grade central osteosarcoma, fall within the morphologic differential diagnosis of parosteal osteosarcoma. Somatic mutations in GNAS, encoding the α-subunit of the heterotrimeric G protein complex (Gsα), occur in FD and McCune-Albright syndrome but have not been reported in parosteal osteosarcoma. Read More

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http://dx.doi.org/10.1097/PAS.0000000000000144DOI Listing
March 2014
8 Reads

MR findings of the osteofibrous dysplasia.

Korean J Radiol 2014 Jan-Feb;15(1):114-22. Epub 2014 Jan 8.

Department of Orthopedic Surgery, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.

Objective: The aim of this study was to describe MR findings of osteofibrous dysplasia.

Materials And Methods: MR images of 24 pathologically proven osteofibrous dysplasia cases were retrospectively analyzed for a signal intensity of the lesion, presence of intralesional fat signal, internal hypointense band, multilocular appearance, cortical expansion, intramedullary extension, cystic area, cortical breakage and extraosseous extension, abnormal signal from the adjacent bone marrow and soft tissue and patterns of contrast enhancement.

Results: All cases of osteofibrous dysplasia exhibited intermediate signal intensity on T1-weighted images. Read More

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http://synapse.koreamed.org/Synapse/Data/PDFData/0068KJR/kjr
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http://synapse.koreamed.org/DOIx.php?id=10.3348/kjr.2014.15.
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http://dx.doi.org/10.3348/kjr.2014.15.1.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909842PMC
April 2014
8 Reads

Imaging in osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma, and classic adamantinoma.

Clin Radiol 2014 Feb 5;69(2):200-8. Epub 2013 Nov 5.

Department of Radiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK.

Fibro-osseous lesions of the bone are well-recognized primary bone tumours. However, given the degree of overlap of imaging findings and variation in management of various sub-types, it is a widely accepted practice to perform a biopsy to obtain histopathological confirmation of the diagnosis. The following is a summary of the epidemiology, clinicopathological features, and review of the imaging features of fibro-osseous lesions, including osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma, adamantinoma, and lesions that closely mimic them. Read More

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http://dx.doi.org/10.1016/j.crad.2013.09.011DOI Listing
February 2014
2 Reads

Congenital osteofibrous dysplasia Campanacci: spontaneous postbioptic regression.

J Pediatr Hematol Oncol 2014 Apr;36(3):249-52

*Department of Radiology and Sarcoma Center Berlin-Brandenburg, HELIOS Klinikum Berlin-Buch §Institute for Pathology, Reference Center for Orthopedic Pathology, HELIOS Klinikum Emil-von-Behring, Stiftung Oskar-Helene-Heim, Berlin and Sarcoma Center Berlin-Brandenburg, Berlin †Department of Radiology, Klinikum Augsburg, Augsburg ‡Department of Clinical Radiology, Medical University Münster, Münster, Germany.

Osteofibrous dysplasia Campanacci is a rare benign bone tumor most frequently observed in young childhood. The exclusive localization in the tibia is very characteristic. The incidence of congenital primary bone tumors is an absolute rarity. Read More

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http://dx.doi.org/10.1097/MPH.0b013e31829b7f79DOI Listing
April 2014
16 Reads

The role of MRI and CT in diagnosis and treatment planning of cherubism: a 13-year follow-up case report.

Eur J Paediatr Dent 2013 Mar;14(1):73-6

Sapienza University of Rome, Rome, Italy.

Aim: Cherubism is characterised by mesenchymal alterations during the development of the jaws secondary to perivascular fibrosis. According to the ALARA (As Low As Reasonably Achievable) principle, it is important to avoid conditions where the amount of radiation used is more than that needed for the procedure, because there is no benefit from unnecessary radiation. However, the use of MRI has been poorly studied in cherubism. Read More

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March 2013
2 Reads

Dentine matrix protein 1 (DMP-1) is a marker of bone-forming tumours.

Virchows Arch 2013 May 5;462(5):583-91. Epub 2013 Apr 5.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, Oxford, OX3 7HE, UK.

Dentin matrix protein 1 (DMP-1) is highly expressed by osteocytes and is a non-collagenous matrix protein found in dentin and bone. In this study, we determined the expression of DMP-1 in mature and immature human bone and examined whether DMP-1 is useful in distinguishing osteoid/bone-forming tumours from other primary and secondary bone tumours. DMP-1 expression was immunohistochemically determined in paraffin sections of a wide range of benign and malignant primary bone tumours and tumour-like lesions (n = 353). Read More

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http://dx.doi.org/10.1007/s00428-013-1399-zDOI Listing
May 2013
4 Reads

[A case of fibrous dysplasia of temporal bone].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2012 Dec;26(23):1098

Osteofibrous dysplasia is a kind of innocent bone tumor derived from fibrous tissue. Its pathogens has not been identified, it rarely affects the temporal bone, its clinical manifestations mainly is hearing loss. Imageological examination, for example, CT and MRI, is valuable for the diagnosis of this disease,the histopathological evidence is absolutely necessary to make definite diagnosis. Read More

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December 2012
2 Reads

Diagnostic value of investigating GNAS mutations in fibro-osseous lesions: a retrospective study of 91 cases of fibrous dysplasia and 40 other fibro-osseous lesions.

Mod Pathol 2013 Jul 1;26(7):911-21. Epub 2013 Feb 1.

Department of Pathology, Tours University Hospital and University François Rabelais, Tours, France.

GNAS (guanine nucleotide-binding protein/α-subunit) mutations that induce the activation of G-protein α-subunit participate in the pathogenesis of fibrous dysplasia. The aim of this study was to evaluate the sensitivity and specificity of GNAS mutations in fibrous dysplasia and other fibro-osseous lesions, to assess the value of investigating this mutation in the diagnosis of fibro-osseous lesions. We studied 91 cases of fibrous dysplasia. Read More

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http://dx.doi.org/10.1038/modpathol.2012.223DOI Listing
July 2013
40 Reads

Gingival fibromatosis with multiple unusual findings: report of a rare case.

Int J Oral Sci 2012 Dec 7;4(4):221-5. Epub 2012 Sep 7.

Department of Stomatology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Gingival fibromatosis is a rare disease, especially its syndromic form. Here, we review the literatures on gingival fibromatosis and briefly summarize some characters on clinical, etiological, genetic and histopathological aspects. We also present a rare case of gingival fibromatosis with multiple unusual findings in a 21-year-old man. Read More

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http://dx.doi.org/10.1038/ijos.2012.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633067PMC
December 2012
1 Read

Fibro-Osseous Lesions.

Surg Pathol Clin 2012 Mar 15;5(1):201-29. Epub 2011 Dec 15.

Department of Pathology, University of Florida, 1600 South West Archer Road, Gainesville, FL 32610, USA.

This article describes the clinical, radiographic, gross, microscopic, and histologic features; differential diagnosis; molecular pathology; treatment; and prognosis of fibrous dysplasia, osteofibrous dysplasia, and adamantinoma of long bones. Read More

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http://dx.doi.org/10.1016/j.path.2011.07.013DOI Listing

Is there a link between osteofibrous dysplasia and adamantinoma?

Orthop Traumatol Surg Res 2011 Dec 11;97(8):877-80. Epub 2011 Nov 11.

Pediatric orthopedic surgery department, Saint-Vincent de Paul hospital, 74, avenue Denfert-Rochereau, 75014 Paris, France.

Because of the relative frequency of osteofibrous dysplasia (OFD) and the gravity of adamantinoma, it is important to know whether there is a link between these two entities. A young boy had been followed from the age of 5 years for OFD of the right tibia. At the age of 10, biopsy performed because of pain, revealed OFD-like adamantinoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18770568110022
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http://dx.doi.org/10.1016/j.otsr.2011.09.008DOI Listing
December 2011
4 Reads

Prostate-specific membrane antigen: a new potential prognostic marker of osteosarcoma.

Med Oncol 2012 Sep 19;29(3):2234-9. Epub 2011 Oct 19.

Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

Previous studies have demonstrated that the expression of prostate-specific membrane antigen (PSMA) is restricted to endothelium from tumor-associated neovasculature. But the expression of PSMA in osteosarcoma and its clinical significance are unknown. Using immunohistochemical analysis and quantum dot probes, we found that 46. Read More

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http://dx.doi.org/10.1007/s12032-011-0089-4DOI Listing
September 2012
3 Reads

Analysis of stromal cells in osteofibrous dysplasia and adamantinoma of long bones.

Mod Pathol 2012 Jan 7;25(1):56-64. Epub 2011 Oct 7.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Oxford, UK.

Adamantinoma of long bones and osteofibrous dysplasia are rare, osteolytic primary bone tumours of uncertain origin containing areas of fibrous and fibro-osseous proliferation. We investigated the nature of the stromal cells in adamantinoma of long bones and osteofibrous dysplasia, and determined cellular and molecular mechanisms of osteolysis in these tumours. Cell culture, molecular (RT-PCR, western blot) and immunohistochemical studies on cases of adamantinoma of long bones and of osteofibrous dysplasia were undertaken to determine the expression of epithelial, osteoblast and osteoclast markers. Read More

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http://dx.doi.org/10.1038/modpathol.2011.141DOI Listing
January 2012
12 Reads
3 Citations
6.190 Impact Factor

p63 expression in adamantinoma.

Virchows Arch 2011 Jul 15;459(1):109-13. Epub 2011 Jun 15.

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

Adamantinoma is a rare primary bone neoplasm with epithelial differentiation that is frequently associated with a concomitant fibrous component. Clinical, cytogenetic and histomorphologic overlap has previously been described with osteofibrous dysplasia, thereby suggesting a relationship between these two lesions. We performed a retrospective review of our archives to characterize the clinical and pathologic aspects of adamantinoma and osteofibrous dysplasia diagnosed at our institution, and to compare the expression patterns of p63 and keratin. Read More

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http://dx.doi.org/10.1007/s00428-011-1101-2DOI Listing
July 2011
19 Reads

Podoplanin expression in adamantinoma of long bones and osteofibrous dysplasia.

Virchows Arch 2011 Jul 16;459(1):41-6. Epub 2011 Apr 16.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Nuffield Orthopaedic Centre, Oxford OX3 7LD, UK.

Adamantinoma of long bones (ALB) and osteofibrous dysplasia (OFD) are rare osteolytic bone tumours that principally arise in the tibia. Both ALB and OFD contain epithelial and stromal elements, as well as areas of fibro-osseous proliferation. We assessed expression of podoplanin, a glycoprotein found in osteocytes, in OFD and ALB as well as in fibrous dysplasia and metastatic cancer. Read More

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http://link.springer.com/10.1007/s00428-011-1081-2
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http://dx.doi.org/10.1007/s00428-011-1081-2DOI Listing
July 2011
5 Reads

Neonatal osteofibrous dysplasia associated with pathological tibia fracture: a case report and review of the literature.

J Pediatr Orthop B 2012 Mar;21(2):183-6

Department of Neonatology, Uludag University, Faculty of Medicine, Bursa, Turkey.

Osteofibrous dysplasia is a rare and benign disease that originates from the tibia or fibula. The symptoms of osteofibrous dysplasia include painless enlargement and bowing of the tibia and pain occurring in the presence of pathological fracture. Herein a male infant who was admitted with redness and swelling on the right leg and diagnosed as pathological tibia fracture due to left tibia osteofibrous dysplasia on the third day of life was presented. Read More

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/BPB.0b013e328344fd41DOI Listing
March 2012
4 Reads

Quantitative analysis of activating alpha subunit of the G protein (Gsα) mutation by pyrosequencing in fibrous dysplasia and other bone lesions.

J Mol Diagn 2011 Mar;13(2):137-42

Division of Molecular Pathology, Department of Scientific Laboratories, Armed Forces Institute of Pathology, Washington, DC 20306, USA.

Benign fibro-osseous lesions (BFOLs) frequently display overlapping histological features. The differentiation of fibrous dysplasia (FD) from other BFOLs can be difficult, even for experienced orthopedic pathologists. Accurately distinguishing FD from other BFOLs may have significant clinical and treatment implications. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2010.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128572PMC
March 2011
2 Reads