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Neurosurgery 2019 Mar 28. Epub 2019 Mar 28.

Department of Neurosurgery, The University of Illinois at Chicago, Chicago, Illinois.

J Hand Surg Am 2019 Mar 22. Epub 2019 Mar 22.

Granovsky-Gluskin Division of Orthopaedic Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

Osteoblastoma is a benign aggressive primary bone tumor that occasionally presents in the hand. Because surgical treatment remains the mainstay of treatment, there are no established nonsurgical pharmacological options for patients in whom resection is not feasible. Novel therapies, such as denosumab, are currently being investigated in primary bone tumors. Read More

Skeletal Radiol 2019 Mar 8. Epub 2019 Mar 8.

Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, 55 Fruit Street Yawkey 6E, Boston, MA, 02114, USA.

Osteoblastoma is a rare, benign primary tumor of bone, accounting for < 1% of all bone tumors. We report the case of a 27-year-old female who developed pain and swelling five and a half years after a clavicular fracture and was subsequently found to have an osteoblastoma arising at the fracture site. This is the first reported case of an osteoblastoma developing after a fracture, although osteoid osteomas, which are histologically indistinguishable from osteoblastomas, have been reported at prior fracture sites. Read More

J Clin Neurosci 2019 May 28;63:22-26. Epub 2019 Feb 28.

Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Aichi 466-8550, Japan. Electronic address:

Primary tumors of the spine are uncommon compared to metastases. The objective of the study was to examine the utility of O-arm navigation-assisted surgery for a primary spine tumor. A prospective study was performed in 18 consecutive patients who underwent O-arm navigation-assisted surgery for a primary spine tumor at our hospital between 2014 and 2017. Read More

Orthopedics 2019 Feb 26:1-3. Epub 2019 Feb 26.

The authors report an osteoblastoma-like variant of osteosarcoma of the right ischial tuberosity in a 14-year-old boy. Radiographs initially showed a bone-forming lesion of the right ischial tuberosity. The patient underwent biopsy with curettage and bone grafting, with final pathology revealing osteoblastoma. Read More

Am J Surg Pathol 2019 May;43(5):610-617

Departments of Anatomic Pathology.

The existence of "aggressive" osteoblastoma (OB) or malignant transformation of OB is controversial. Over a few decades, we have encountered a group of "borderline" sclerosing osteoblastic lesions that are difficult to classify, tending toward local recurrence, especially following curettage. A search of the consultative and institutional files from 3 co-authors for atypical OB, malignant transformation of OB, well-differentiated osteosarcoma (OS), and OB-like OS diagnoses revealed 8 similar cases. Read More

Med Sci Monit 2019 Feb 20;25:1362-1372. Epub 2019 Feb 20.

Department of Bone and Musculoskeletal Tumor Center, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China (mainland).

BACKGROUND Osteoblastoma is a rare, benign, osteolytic neoplasm commonly found in the spine in early adulthood. Here, we review the clinical characteristics, radiographic findings, and surgical management of patients with spinal osteoblastoma. MATERIAL AND METHODS Thirteen patients with osteoblastoma who underwent surgery at our institute from June 2008 to November 2017 were enrolled in this study. Read More

Rev Esp Cir Ortop Traumatol 2019 Mar - Apr;63(2):122-131. Epub 2019 Feb 8.

Unidad de Raquis, Servicio de Traumatología y Ortopedia Infantil, Hospital Infantil Universitario Niño Jesús, Madrid, España.

Introduction And Objective: Osteosarcoma is the most frequent malignant spinal tumour in the paediatric age group. Diagnosis and early treatment of this pathology is essential for a good prognosis. The aim of this study was to present the results of treatment of paediatric patients with lumbar osteosarcoma and conduct a literature review. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Dec 31. Epub 2018 Dec 31.

Associate Professor of Clinical Specialty, Department of Diagnostic Radiology, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

Epithelioid osteoblastoma is a clinically aggressive subtype of osteoblastoma that favors the mandible and the maxilla. Its histologic features lie on a spectrum between conventional osteoblastoma and low-grade osteosarcoma, thus making it difficult at times to confirm the diagnosis. It is known to have a high risk of recurrence after surgical resection, but it is a benign entity and does not have the propensity to metastasize. Read More

Oral Radiol 2019 Jan 25. Epub 2019 Jan 25.

Department of Oral Medicine and Radiology, Amrita School of Dentistry, AIMS Campus, Ponekkara, Kochi, 682041, India.

Osteoblastoma is a rare, benign type of osteoblastic tumor. It constitutes approximately 1% of all primary bone tumors. Osteoblastoma most commonly affects the long bones; it very rarely affects the jaw bones. Read More

Pediatr Neurosurg 2019 23;54(1):46-50. Epub 2019 Jan 23.

Department of Neurosurgery, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.

Osteoblastomas and aneurysmal bone cysts are uncommon benign tumors of the spine. Their presentation can vary between diffuse pain, restriction of neck movements, torticollis, radiculopathy, and myelopathy. Complete excision is the best treatment to achieve a cure, but recurrence is not uncommon. Read More

Radiol Case Rep 2019 Mar 4;14(3):400-404. Epub 2019 Jan 4.

Creighton University School of Medicine, Phoenix Regional Campus, St. Joseph's Hospital & Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA.

An osteoid osteoma is a benign bone tumor that arises from osteoblastic dysfunction and usually presents as nonspecific, nocturnal pain located in the diaphysis of long bones, with <1% occurring in the ribs. It is most commonly treated with nonsteroidal anti-inflammatory drugs or merely observed; when these treatments do no prove efficacious, either open surgery or interventional ablation are pursued. Herein, we report a rare case of an osteoid osteoma located in the rib of a 19-year-old male that was histologically diagnosed through computed tomography (CT)-guided biopsy. Read More

Genes Chromosomes Cancer 2019 02 24;58(2):88-99. Epub 2018 Dec 24.

Department of Pathology, The Royal National Orthopaedic Hospital, Stanmore, Middlesex, United Kingdom.

The last decade has seen the majority of primary bone tumor subtypes become defined by molecular genetic alteration. Examples include giant cell tumour of bone (H3F3A p.G34W), chondroblastoma (H3F3B p. Read More

Neurosurgery 2018 Dec 12. Epub 2018 Dec 12.

Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island.

World Neurosurg 2019 Mar 3;123:378-382. Epub 2018 Dec 3.

Department of Pathology, University of California, Los Angeles, California, USA. Electronic address:

Background: Epithelioid osteoblastoma of the cranium is extremely rare and can mimic other etiologies on radiographic imaging, pathology, and symptomatology.

Case Description: An 18-year-old male patient had a 3-week history of a palpable left temporal mass. Magnetic resonance imaging revealed a large, extra-axial, hypervascular mass in the left temporal bone, with bony erosion and intracranial extension. Read More

Neurosurgery 2018 Nov 27. Epub 2018 Nov 27.

Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Background: Osteoblastoma (OBL) in the mobile spine is a benign tumor with aggressive potential. There is not much published information on OBL of the mobile spine as a result of rarity of the disease. There are controversies over the aggressive subtype and prognostic factors of the condition. Read More

Eur J Nucl Med Mol Imaging 2019 Apr 19;46(4):1019-1036. Epub 2018 Oct 19.

Department of Radiology and Nuclear Medicine, Cantonal Hospital Lucerne, Lucerne, Switzerland.

Osteoid osteoma is a painful, benign, osteoblastic lesion that occurs in younger patients and affects the extremities or the axial skeleton. While plain film findings may suggest the diagnosis, in complex anatomical regions such as the spine, pelvis, wrist and foot advanced imaging modalities are often required. A typical nidus surrounded by sclerosis or cortical thickening characterizes osteoid osteoma on plain radiography and CT. Read More

Medicine (Baltimore) 2018 Oct;97(42):e12803

Department of General Surgery, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou, China.

Rationale: Osteoblastoma is an uncommon primary bone tumor that involves any part of the skeleton. But its occurrence in the skull is extremely rare.

Patients Concerns: A 30-year-old female was admitted to our hospital, because of the mass in the right frontal region with the history of headache for 3 years without nausea or vomiting. Read More

Radiologia 2019 Mar - Apr;61(2):167-170. Epub 2018 Sep 28.

Servicio de Diagnóstico por Imágenes, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Sternal tumours are rare in children. The differential diagnoses include a wide spectrum of benign (from bone cyst to osteoblastoma, osteochondroma and fibrous displasia) and malignant tumours (Ewing's sarcoma, chondrosarcoma rhabdomyosarcoma), inflammatory lesions and infectious processes. The SELSTOC (Self Limiting Sternal Tumours of Childhood) are entities of non-specific origin, they are self-limiting and characterised by a rapidly growing tumour that disappears spontaneously with no history of trauma or active infection. Read More

Clin Sarcoma Res 2018 5;8:18. Epub 2018 Sep 5.

1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal and Sciences, Nuffield Orthopaedic Centre, University of Oxford, Oxford, OX3 7HE UK.

Background: Periostin is a matricellular protein that is expressed in bone and joint tissues. To determine the expression of periostin in primary bone tumours and to assess whether it plays a role in tumour progression, we carried out immunohistochemistry and ELISA for periostin in a range of neoplastic and non-neoplastic bone and joint lesions.

Methods: 140 formalin-fixed paraffin-embedded sections of bone tumours and tumour-like lesions were stained by an indirect immunoperoxidase technique with a polyclonal anti-periostin antibody. Read More

Cytojournal 2018 27;15:20. Epub 2018 Aug 27.

Department of Orthopaedics, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India.

Osteoblastoma is a rare bone tumor mostly affecting the young adults and commonly involving the spinal cord and long bones. Talus is the uncommon site of presentation, and if involved, then the neck is more commonly involved than the body of talus. The cytological diagnosis of osteoblastoma is limited, and to the best of our knowledge, its fine-needle aspiration (FNA) in the talus has still not been reported in the literature. Read More

Orthopade 2019 Apr;48(4):343-347

Department of Orthopedics, Artificial Joints Engineering and Technology Research Center of Jiangxi Province and Multidisciplinary Therapy Center of Musculoskeletal Tumor, The First Affiliated Hospital of Nanchang University, 330006, Nangchang, Jiangxi, China.

Background: An osteoblastoma is a rare benign bone tumor characterized by formation of osteoid tissue and primitive bone and occurs more often in men than in women. They are often secondary to an osteoid osteoma and can be located at any site on the skeleton. Lesions generally involve the posterior elements of the spine, such as the pedicle and the lamina. Read More

J Oral Biol Craniofac Res 2018 Sep-Dec;8(3):203-205. Epub 2017 Jul 1.

Department of Oral Pathology, Government Dental College and Hospital, St. George Hospital Campus, Near Chhatrapati Shivaji Terminus Area, Fort, Mumbai, Maharashtra 400001, India.

Radiolucent lesions of Temporomandibular Joint (TMJ) represent a diagnostic challenge and a treatment conundrum. Biopsy of the lesions is technically difficult owing to their complex anatomy. The Differential Diagnosis (DD) includes a wide array of lesions including Simple Bone Cyst, Ameloblastoma, Central Giant Cell Granuloma, Hemangioma, Osteoblastoma, Osteochondroma, Chondroblastoma, Chondrosarcoma, Neurofibroma and metastatic malignant lesions though none has a specific predilection for TMJ. Read More

Ann Otol Rhinol Laryngol 2018 Nov 6;127(11):864-869. Epub 2018 Sep 6.

2 Department of Otolaryngology- Head & Neck Surgery, University of Washington, Seattle, Washington, USA.

Objective: Describe a novel treatment approach to a rare bony neoplasm in the frontal sinus.

Study Design: Case report.

Methods: Retrospective chart review of an osteoblastoma of the frontal sinuses complicated by a right orbital mucocle. Read More

Histopathology 2019 Feb 4;74(3):494-503. Epub 2018 Nov 4.

Department of Pathology, IRCCS Rizzoli Orthopaedic Institute, Bologna, Italy.

Aims: Osteoblastoma-like osteosarcoma is a rare variant of osteosarcoma (1% of all osteosarcomas), histologically similar to osteoblastoma. In the current World Health Organisation (WHO) classification, osteoblastoma-like osteosarcoma is classified within the group of conventional (high-grade) osteosarcomas. However, several published cases have been actually regarded as low-grade malignant tumours. Read More

Am J Rhinol Allergy 2018 Nov 22;32(6):465-472. Epub 2018 Aug 22.

3 Rick and Tina Caruso Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California.

Background: Pediatric benign paranasal sinus osteoneogenic tumors have previously been difficult to treat due to the surgical constraints of the developing skull. Progression may lead to intracranial complications or orbital and optic nerve compression.

Objective: To assess the presentation and management of benign paranasal sinus osteoneogenic tumors. Read More

Acta Orthop Traumatol Turc 2019 Jan 9;53(1):77-80. Epub 2018 Aug 9.

Bağcılar Training and Research Hospital, Department of Radiology, İstanbul, Turkey. Electronic address:

We report a 14-year-old boy who presented with pain in the left foot and ankle for about 9 months. The clinical symptoms of the patient suggested complex regional pain syndrome (CRPS). The radiographs and magnetic resonance imaging studies ravealed a bone tumor in the talus, consistent with an osteoblastoma. Read More

Pan Afr Med J 2018 20;29:164. Epub 2018 Mar 20.

Service de Chirurgie Orthopédique, CHU Rabat, Hopital Ibn Sina, Université Mohammed V, Souissi, Maroc.

Osteoblastoma is a rare benign bone tumor occurring in adults younger than 30 years, with a clear predominance in men. It mainly occurs at the level of the spine and of the diaphysis in long bones. It occurs exceptionally in the ankle. Read More

Acta Biomed 2018 Jun 7;89(2):269-273. Epub 2018 Jun 7.

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We reported the case of a 22 year-old boy who suffered a periosteal osteoblastoma of the distal fibula. The radiographic features of our case did not correlate with the majority of periosteal osteoblastomas of the long bones reported in the literature and were identical to a periosteal aneurysmal bone cyst. Periosteal osteoblastoma is a very rare tumor with a wide range of clinical and radiological features, showing in 15% of cases association with secondary aneurysmal bone cyst. Read More

J Clin Orthop Trauma 2018 Jun 18;9(Suppl 2):S21-S25. Epub 2017 Sep 18.

Department of Radiology, University College of Medical Sciences and Guru Teg Bahadur hospital, Dilshad Garden, Delhi, 110095, India.

Osteoblastoma is a rare tumor and represents about 0.8% of all bone tumors. The aggressive variant is even rarer and difficult to diagnose. Read More

Nat Commun 2018 06 1;9(1):2150. Epub 2018 Jun 1.

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, UK.

The transcription factor FOS has long been implicated in the pathogenesis of bone tumours, following the discovery that the viral homologue, v-fos, caused osteosarcoma in laboratory mice. However, mutations of FOS have not been found in human bone-forming tumours. Here, we report recurrent rearrangement of FOS and its paralogue, FOSB, in the most common benign tumours of bone, osteoblastoma and osteoid osteoma. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2017 09;31(9):1069-1072

Department of Bone Tumor Surgery, Orthopedics Center, the First Affiliated Hospital of Xinjiang Medical University, Urumchi Xinjiang, 830054,

Objective: To discuss the effect of three-dimensional (3D) printing individualized model and guide plate in bone tumor surgery.

Methods: Between October 2015 and December 2016, 3D printing individualized model and guide plate for making preoperative surgical planning and intraoperative treatment were used in 5 patients of bone tumor. All the patients were male, with a median age of 32 years (range, 9-58 years). Read More

Chin J Dent Res 2018;21(2):147-149

Benign osteoblastoma is a rare bone tumour characterised histologically by the production of woven bone spicules, which are bordered by prominent osteoblasts. It mainly affects young adults. We report a rare case of benign osteoblastoma of the maxilla in a 7-year-old boy who presented with a painful swelling on the left hard palate. Read More

Oral Oncol 2018 Jul 18;82:198-199. Epub 2018 May 18.

Oral & Maxillofacial Surgery Department, Mid-Essex Hospitals Trust, Chelmsford, UK.

Sichuan Da Xue Xue Bao Yi Xue Ban 2018 Jan;49(1):129-132

Department of Orthopaedics,West China Hospital,Sichuan University,Chengdu 610041,China.

Objective: To investigate the surgical techniques and mid-term efficacy of reconstruction for proximal femur with allograft-prosthetic composite (APC) .

Methods: Fifteen patients who underwent uncemented APC reconstruction of proximal femur after bone tumor resection were retrospectively evaluated. Image and physical examinations were taken on the 1st,3rd,6th,9th and 12th month after surgery and every 6 months thereafter to assess union condition,greater trochanteric bone absorption and myodynamia of abductors. Read More

J Surg Oncol 2018 Jun 3;117(8):1786-1798. Epub 2018 May 3.

Queen Elizabeth II Health Sciences Center, Halifax Infirmary, Dalhousie University, Halifax, Nova Scotia, Canada.

Bone tumors are relatively rare in the foot and ankle region. Many of them present as cystic lesions on plain films. Due to the relative rarity of these lesions and the complex anatomy of the foot and ankle region, identification of such lesions is often delayed or they get misdiagnosed and mismanaged. Read More

Future Oncol 2018 Dec 25;14(28):2945-2955. Epub 2018 Apr 25.

Department of Biotechnology & Applied Clinical Science, University of L'Aquila, L'Aquila, Italy.

Interventional radiology has experienced an exponential growth in the last years. Nowadays it is possible to treat painful benign lesions or metastases with optimal results in terms of pain management and disease control. Among the benign lesions, osteoid osteoma is the most frequently treated with minimal invasive techniques and the results are excellent. Read More

Am J Rhinol Allergy 2018 Mar 23;32(2):82-84. Epub 2018 Mar 23.

2 Rush Sinus Program, Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois, and.

Background: With the exception of osteomas, bone neoplasms that originate in the sinonasal cavity are seldom diagnosed on preoperative imaging due to a lack of characteristic radiographic features. Here we described the unusual occurrence of an osteoblastoma in the paranasal sinuses, and we drew focus to its salient imaging features. A highly unique imaging sign was indicated, and its pathologic basis was explained, with concurrent review of the literature. Read More

Am J Surg Pathol 2018 Jun;42(6):744-749

Division of Pathology.

Osteogenic sarcoma (OS) is the most common malignant bone tumor in children and adolescents. Despite advances in molecular genetic characterization of pediatric and adult tumors, the diagnosis of OS still depends almost entirely on light microscopy. The lack of consistent genetic changes in OS has greatly hindered the development of any diagnostic molecular test. Read More

Skeletal Radiol 2018 Oct 10;47(10):1443-1448. Epub 2018 Mar 10.

John Theurer Cancer Center, Hackensack University Medical Center, 20 Prospect Avenue, Suite 501, Hackensack, NJ, 07601, USA.

We report a rare case of giant periosteal osteoblastoma in the femur of a 21-year-old male. The patient presented with a painful, firm, non-tender mass in his left thigh. The pain was worse at night and was temporarily relieved with NSAIDS. Read More

Head Neck Pathol 2018 Mar 5. Epub 2018 Mar 5.

Consultant Oral and Maxillofacial Surgeon, Monash Health, Melbourne, VIC, Australia.

The diagnosis of osteomas in the paediatric population can pose a challenge to pathologists in excluding malignant bony tumours. We present the case of a 10-year old male presenting with a large left mandibular radiopaque lesion. This paper discusses the case of a central osteoma with osteoblastoma-like features, literature review, differential diagnosis of radiopaque lesions of the maxilla and mandible as well as a detailed discussion of the pathology of the lesion. Read More

Skeletal Radiol 2018 Aug 15;47(8):1183-1189. Epub 2018 Feb 15.

Complejo Hospitalario Univeritario de Ferrol, A Coruña, Spain.

Osteoblastomatosis (OBLT), also referred to as multifocal osteoblastoma (OB), is an unusual and recently described entity consisting of multifocal tumors histologically consistent with osteoblastoma and osteoid osteoma (OO) but radiologically mimicking a vascular bone lesion. OBLT treatment is based on aggressive procedures, such as amputation, en bloc resection, and chemotherapy. Only one previously reported case was successfully treated following a multimodal approach consisting of curettage, cryotherapy, intravenous bisphosphonates, and radiofrequency ablation. Read More

World Neurosurg 2018 Apr 5;112:243-246. Epub 2018 Feb 5.

Department of Neurosurgery, Policlinico San Martino, University of Genoa, Genoa, Italy.

Background: Osteoblastoma is a benign bone-forming tumor, sometimes locally invasive, that may involve any bone. The highest incidence is between 20 and 30 years of age, and there are no cases described in the elderly.

Methods: We report a case of an elderly patient with a lesion in the lumbar spine in which osteoblastoma diagnosis was made. Read More

Eur Spine J 2018 07 29;27(Suppl 3):477-482. Epub 2018 Jan 29.

Orthopaedics Department, Centro Hospitalar Lisboa Norte, University Hospital of Santa Maria, Avenida Professor Egas Moniz, 1649-035, Lisbon, Portugal.

Introduction: The anterior elements of the spine, particularly the odontoid processes, are a rare location for osteoblastomas. Pseudomalignant osteoblastomas are themselves rare histologic types and are also extremely rare in this location. Most osteoblastomas are Enneking stage 2 lesions; less frequently, they can be more aggressive with extra-capsular extension (Enneking stage 3). Read More

Eur Spine J 2018 07 22;27(Suppl 3):446-452. Epub 2018 Jan 22.

Division of Spinal Surgery, University of Oxford, Oxford, England, UK.

Purpose: To present a case of aggressive sacral osteoblastoma (OB) treated with neoadjuvant denosumab therapy and en bloc resection.

Methods: Case report of a 14-year-old male with an aggressive OB affecting the superior articular process of the left first sacral segment. The lesion was lytic and metabolically active and involved the left-sided posterior elements of S1-S3 with extension into the spinal canal, affecting the left S1, S2, S3, S4 and S5 nerve roots. Read More

Lancet Oncol 2018 01;19(1):26

Division of Paleopathology, University of Pisa, Pisa, Italy.

BMC Musculoskelet Disord 2017 Dec 19;18(1):538. Epub 2017 Dec 19.

Department of Orthopedic Surgery, West China Hospital, Sichuan University, No. 37 GuoXue Road, Chengdu, Sichuan, 610041, China.

Background: Osteoblastoma is a rare and benign tumor which requires early diagnosis and surgical excision. Scoliosis is a common presentation following osteoblastoma. It is considered due to pain-provoked muscle spasm on the side of the lesion. Read More