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Insights Imaging 2020 Jun 29;11(1):80. Epub 2020 Jun 29.

Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Spinal osseous neoplasms are frequently encountered and can be challenging when present as solitary lesions. Familiarity with the range of benign and malignant spinal pathology can help the radiologist formulate a comprehensive differential diagnosis. This article focuses on the spectrum of extradural spinal tumors, accounting for the majority of primary spinal tumors, by comparing the epidemiology, pathophysiology, clinical presentation, and characteristic imaging appearance of these lesions. Read More

Tech Vasc Interv Radiol 2020 Jun 27;23(2):100677. Epub 2020 May 27.

Imagerie interventionnelle, Hôpitaux Universitaires de Strasbourg, Strasbourg Cedex, France.

Percutaneous thermal ablation has proven to be safe and effective in the management of patients with spinal tumors. Such treatment is currently proposed following the decision of a multidisciplinary tumor board to patients with small painful benign tumors such as osteoid osteoma or osteoblastoma, as well as carefully selected patients presenting with spinal metastases. In both scenarios, in order to provide a clinically effective procedure, ablation is often tailored to the specific patients' clinical needs and features of the target tumor. Read More

J Orthop Surg Res 2020 06 24;15(1):236. Epub 2020 Jun 24.

Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, 127# West Changle Road, Xi'an, 710032, Shaanxi Province, China.

An amendment to this paper has been published and can be accessed via the original article. Read More

FP Essent 2020 Jun;493:11-21

UNC Department of Family Medicine, 590 Manning Drive, Chapel Hill, NC 27599.

Primary benign bone tumors are uncommon and most often affect children and young adults. They typically are detected incidentally on imaging, though some patients present with pain, swelling, or other symptoms. The four main categories of benign bone tumor are: bone-forming (eg, osteoid osteoma, osteoblastoma, fibrous dysplasia, enostosis), cartilage-forming (eg, osteochondroma, enchondroma), connective tissue, and vascular; the latter two are rare. Read More

World Neurosurg 2020 Jun 19. Epub 2020 Jun 19.

Department of Neurosurgery, AIIMS, New Delhi 110029, India.

Osteoblastoma is a rare nonfibroblastic osteoid tissue forming primary bony tumor usually arising in the medullary cavity /diploic space of any bone. Calvarium is an extremely rare site of its origin. Clinically, two types of Osteoblastomas are noted: benign/conventional/typical and aggressive/high grade. Read More

J Pathol Clin Res 2020 Jun 16. Epub 2020 Jun 16.

Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, Lund, Sweden.

Osteoblastoma is a locally aggressive tumour of bone. Until recently, its underlying genetic features were largely unknown. During the past two years, reports have demonstrated that acquired structural variations affect the transcription factor FOS in a high proportion of cases. Read More

J Clin Neurosci 2020 Jun 4. Epub 2020 Jun 4.

Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Radiology, Mayo Clinic, Rochester MN, USA. Electronic address:

Spinal solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a rare mesenchymal malignancy. Radiographically, SFT/HPCs have a mutable appearance, with irregular borders, heterogeneous contrast enhancement, and variable but frequently hypointense T2 signal. We report a series of 5 neurosurgically managed spinal SFT/HPCs treated at our institution, with particular attention to 3 lesions demonstrating marked T2-hypointensity and differential diagnosis for the unusual finding of a "T2 dark" spinal lesion. Read More

Oper Neurosurg (Hagerstown) 2020 Jun 7. Epub 2020 Jun 7.

Division of Neurosurgery, Sainte-Justine University Hospital Center, Montreal, Canada.

Background: Osteoblastomas are locally aggressive bone tumors typically affecting the posterior elements of the vertebral column. The treatment of choice is total surgical resection, traditionally through an open laminectomy, often with facetectomy and fusion when the lesion is in the foramen.

Objective: To seek an alternative to open surgery, allowing quick and full functional recovery, to meet the youth and athlete population's specific surgical goals. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 May 29. Epub 2020 May 29.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Department of Oral Pathology and Oral Biology, School of Dentistry, University of Pretoria, Pretoria, South Africa. Electronic address:

Objective: The aim of this study was to describe the clinicopathologic features of a series of gnathic epithelioid osteoblastomas. As high levels of Proto-oncogene c-Fos proteins resulting from FOS-FOSB translocation were recently demonstrated in osteoblastomas, we also evaluated the immunoexpression of these proteins.

Study Design: Records of all cases of epithelioid osteoblastoma of the jaws were retrieved from oral pathology services, and their clinicopathologic and immunohistochemical data were collected. Read More

J Orthop Surg Res 2020 May 24;15(1):181. Epub 2020 May 24.

Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, 127# West Changle Road, Xi'an, 710032, Shaanxi Province, China.

Background: Osteoblastoma (OB) is an intermediate lesion, which makes the accurate preoperative diagnosis very important. Tc-methylene diphosphonate (Tc-MDP) bone scan and SPECT/CT imaging were evaluated for their diagnostic value in spinal OB.

Methods: This study was a retrospective analysis of patients with spinal OB lesions confirmed by pathology and diagnosed with bone scan and SPECT/CT for preoperative diagnosis from January 2008 to December 2018. Read More

BMC Musculoskelet Disord 2020 May 22;21(1):321. Epub 2020 May 22.

Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, Gunma, 371-8511, Japan.

Background: Although osteoblastoma is an uncommon benign bone tumor, it sometimes behaves in a locally aggressive fashion. We herein report a case of recurrent lumbar spine osteoblastoma that was treated by repeated surgery and carbon ion radiotherapy.

Case Presentation: A 13-year-old Japanese girl presented with left side lumbar pain. Read More

Radiol Case Rep 2020 Jul 7;15(7):955-960. Epub 2020 May 7.

Radiology Department, Texas Children's Hospital, 6621 Fannin St, Houston, TX 77030.

Osteomas are one of the most common benign fibro-osseous lesions affecting the sinonasal tract. Rarely osteomas have osteoblastoma-like areas histologically, which are often misdiagnosed radiologically and pathologically as osteoblastomas. We report the CT and MR imaging findings of 3 cases of osteoma with osteoblastomas-like features in pediatric patients, 1 initially diagnosed as an osteoblastoma. Read More

Contemp Clin Dent 2019 Apr-Jun;10(2):402-405

Department of Oral and Maxillofacial Surgery, Haldia Institute of Dental Sciences and Research, West Bengal University of Health Sciences, Haldia, West Bengal, India.

Osteoblastoma is an uncommon osteoblastic tumor that rarely involves facial bones. It is an uncommon lesion that accounts for 1% of all bone tumors and about 3% of all benign bone tumors. Here, we present a case of 35-year-old female with benign osteoblastoma on the right side of the mandible which was growing for the past 3 years. Read More

BMC Musculoskelet Disord 2020 Apr 14;21(1):240. Epub 2020 Apr 14.

Department of Medical Imaging, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Avenue North, Guangzhou, Guangzhou, Guangdong, 510515, P.R. China.

Background: To analyze the features of CT, MRI and PET/CT and their diagnostic value for spinal osteoblastomas (OBs).

Methods: The radiological and clinical data of 21 patients with histopathologically-confirmed spinal OBs were analyzed retrospectively.

Results: Sixteen of the 21 cases were benign and 5 were aggressive OBs. Read More

World Neurosurg 2020 Jun 3;138:418-421. Epub 2020 Apr 3.

Department of Neurological Surgery, State University of New York, Upstate Medical University, Syracuse, New York, USA. Electronic address:

Background: Osteoblastomas are a type of primary osseous neoplasm that exhibit a proclivity for the spine, primarily the posterior elements. While generally considered benign, some variants of osteoblastoma exhibit aggressive growth with lytic osseous destruction and soft tissue invasion, with some recurring after initial treatment. Given their proximity to vital structures and potential for rapid growth, these tumors are often managed with aggressive surgery, with en-bloc resection preferred. Read More

J Neurosurg Spine 2020 Apr 3:1-4. Epub 2020 Apr 3.

Departments of1Neurological Surgery and.

Osteoblastomas are a rare, benign primary bone tumor accounting for 1% of all primary bone tumors, with 40% occurring within the spine. Gross-total resection (GTR) is curative, although depending on location, this can require destabilization of the spine and necessitate instrumented fixation. Through the use of minimally invasive, muscle-sparing approaches, these lesions can be resected while maintaining structural integrity of the spine. Read More

World Neurosurg 2020 Jun 23;138:339-343. Epub 2020 Mar 23.

Department of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Background: Osteoblastomas are rare primary bone tumors with a predilection for the spine. The extraosseous growth pattern is rare, and to our knowledge, only 2 cases of fully extraosseous osteoblastomas have been previously reported.

Case Description: A man aged 36 years presented with a 7-month history of low back pain radiating to the gluteal area. Read More

Radiol Case Rep 2020 May 20;15(5):610-614. Epub 2020 Mar 20.

Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA.

Osteoblastomas infrequently occur in the calvarium, displaying a preference for temporal and frontal bones when it does. We present an unusual case of a large, expansile osteoblastoma in the occipital bone of a 23-year-old man who presented with a nontender lump at the back of his head. Initial computed tomography scan showed a large occipital bone mass, and after additional imaging, a gross total resection was performed. Read More

J Oral Maxillofac Pathol 2020 Feb 28;24(Suppl 1):S15-S18. Epub 2020 Feb 28.

Department of Oral and Maxillofacial Pathology, YMT Dental College and Hospital, Navi Mumbai, Maharashtra, India.

Cemento-osseous dysplasia (COD) is the most prevalent lesion and presents as an asymptomatic, mixed radiolucent/radiopaque lesion in the tooth-bearing region of the jawbones. Histological features of COD include a cellular connective tissue stroma interspersed by the islands of woven or lamellar bone and cementum-like calcifications. Radiographically, the early COD lesions appear radiolucent, whereas in the mature lesions, radiopacities are observed surrounded by a thin rim of radiolucency. Read More

Int J Hyperthermia 2020 ;37(1):274-282

Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany.

To explore the typical magnetic resonance imaging (MRI) pattern of osteoblastoma (OB) after radiofrequency ablation (RFA) treatment and to identify signs indicating treatment success or relapse. Forty-four follow-up MRI examinations of 15 patients with OB who had undergone 19 RFA procedures were analyzed retrospectively. An early follow-up group (1-4 months after RFA) and a late follow-up group (8-131 months after RFA) were established. Read More

Skeletal Radiol 2020 Mar 12. Epub 2020 Mar 12.

Radiology Department, APHM, Marseille, France.

A 37-year-old man presented with a 2-year history of left hip pain. Pretherapeutic imaging demonstrated a 4 cm osteoblastoma located in the intertrochanteric region of the proximal femur, surrounded by extensive bone marrow edema. After multidisciplinary meeting, percutaneous cryoablation was decided and performed under computed tomography guidance using three cryoprobes to match the exact size and shape of the tumor, resulting in complete resolution of symptoms. Read More

Cancer Genomics Proteomics 2020 Mar-Apr;17(2):161-168

Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

Background/aim: Osteoblastoma is a rare benign tumor of the bones in which recurrent rearrangements of FOS have been found. Our aim was to investigate two osteoblastomas for possible genetic aberrations.

Materials And Methods: Cytogenetic, RNA sequencing, and molecular analyses were performed. Read More

Ann Diagn Pathol 2020 Apr 14;45:151479. Epub 2020 Feb 14.

Section of Histopathology, Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan. Electronic address:

Objectives: Denosumab is Receptor Activator of Nuclear factor Kappa-B Ligand (RANKL) inhibitor which is being used in the treatment of locally advanced, recurrent and metastatic Giant Cell Tumor of Bone (GCTB). It causes reduction in monocyte recruitment and Osteoclast-Like Giant Cell (OLGC) formation which limits bone destruction. After Denosumab treatment, GCTB exhibit diverse morphological features which can pose diagnostic challenge. Read More

Pathologe 2020 Mar;41(2):123-133

Institut für Pathologie, Medizinische Fakultät, Otto-von-Guericke-Universität Magdeburg, Leipziger Straße 44, 39120, Magdeburg, Deutschland.

Osteoid osteoma and osteoblastoma are the most important benign osteoid-forming tumors. They grow slowly and are well differentiated. Histologically, the tumor cells show no atypia and no increased mitoses. Read More

Clin Imaging 2020 Jun 30;62:23-32. Epub 2020 Jan 30.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, United States of America.

Purpose: To describe the imaging, anatomic, and clinical features of a series of secondary aneurysmal bone cysts (ABC) and to ascertain their most commonly associated primary bone lesions.

Methods: Forty-nine cases of histopathologically proven secondary ABCs were retrospectively reviewed. Demographic data and clinical history were obtained. Read More

Pathologe 2020 Mar;41(2):106-115

Knochentumor-Referenzzentrum, Institut für Pathologie, Universitätsspital Basel, Universität Basel, Schönbeinstrasse 40, Basel, 4031, Schweiz.

The integrative evaluation of histology and corresponding imaging is essential for the classification of bone tumors. Until a few years ago, there were hardly any molecular markers that could be used for diagnostic purposes. However, exome- and genome-wide sequencing analyses have since uncovered a number of tumor-specific aberrations that can be very helpful in ambiguous cases. Read More

World Neurosurg 2020 Apr 4;136:150-156. Epub 2019 Dec 4.

Department of Oncological and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Background: Osteoblastoma is a rare benign aggressive tumor, with one third occurring in the spine. Conversion of osteoblastoma to osteosarcoma is uncommon, and histologically proven conversion has been rarely reported.

Case Description: Cases of 2 patients with rare occurrences of spinal osteoblastomas recurring and transforming into osteosarcomas are presented. Read More

Biomed Res Int 2019 29;2019:8206913. Epub 2019 Oct 29.

Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China.

Objective: To explore the incidence and significance of intra- and extra-osseous edema associated with benign tumors and tumor-like diseases.

Methods: Magnetic resonance imaging (MRI) data from 300 benign osseous tumors and tumor-like diseases diagnosed by pathology were retrospectively reviewed. Borderline tumors, cases associated with pathological fractures, and skull lesions were excluded from the study. Read More

Virchows Arch 2020 Mar 25;476(3):455-463. Epub 2019 Nov 25.

Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands.

Osteoid osteoma and osteoblastoma are bone-forming tumors shown to harbor FOS (87%) and FOSB (3%) rearrangements. The aim was to evaluate the immunohistochemical expression of FOS and FOSB in these tumors in comparison to other bone tumors, to evaluate the influence of decalcification, and to correlate immunohistochemical findings with the underlying genetic alteration using fluorescence in situ hybridization (FISH). Immunohistochemistry using whole sections was performed on osteoid osteoma (n=23), osteoblastoma (n=22), osteoblastoma-like osteosarcoma (n=3), reactive (n=3), and proliferative (n=11) bone lesions. Read More

Clin Neurol Neurosurg 2020 01 11;188:105595. Epub 2019 Nov 11.

Department of Orthopaedic Oncology, Spinal Tumor Center, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China. Electronic address:

Objectives: Spinal secondary aneurysmal bone cyst (SABC) is extremely rare with few published reports available at present. Our aim is to explore the clinicopathologic features, surgical modalities and outcomes of spinal SABC.

Patients And Methods: A retrospective study of 33 patients with spinal SABC who were surgically treated in our center between 2010 and 2018 was performed. Read More

J Foot Ankle Surg 2020 Jan - Feb;59(1):156-161. Epub 2019 Nov 19.

Professor, Department of Cardiac Surgery. Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

Osteoblastoma-like osteosarcoma is a rare form of osteosarcoma that shares similar clinical and pathological characteristics with osteoblastoma. We describe a 12-year-old boy with osteoblastoma-like osteosarcoma of the cuboid and skull without lung involvement. Despite inadequate primary surgical treatment, the patient recovered well after wide excision and postoperative chemotherapy. Read More

Virchows Arch 2020 Jan 18;476(1):147-157. Epub 2019 Nov 18.

Department of Pathology, Leiden University Medical Center, P.O. Box 9600, L1-Q, 2300 RC, Leiden, Netherlands.

Bone tumours are difficult to diagnose and treat, as they are rare and over 60 different subtypes are recognised. The emergence of next-generation sequencing has partly elucidated the molecular mechanisms behind these tumours, including the group of bone forming tumours (osteoma, osteoid osteoma, osteoblastoma and osteosarcoma). Increased knowledge on the molecular mechanism could help to identify novel diagnostic markers and/or treatment options. Read More

Spinal Cord Ser Cases 2019 22;5:89. Epub 2019 Oct 22.

3Department of Pathology, All India Institute of Medical Sciences (AIIMS), Jodhpur, Rajasthan India.

Introduction: Osteoblastoma and aneurysmal bone cyst (ABC) are rare bone tumors with individual prevalence of <1%. Their combined occurrence is a rare subclass of tumors in the spinal column with only a few cases reported in literature.

Case Presentation: The present case is a rare combination of aggressive osteoblastoma with secondary aneurysmal bone cyst masquerading as neck pain, arising from cervical C4 vertebra in a 19-year-old male. Read More

J Comp Pathol 2019 Oct 23;172:27-30. Epub 2019 Sep 23.

Texas A&M University, College of Veterinary Medicine and Biomedical Sciences, Department of Veterinary Pathobiology, 668 Raymond Stotzer Pkwy., College Station, Texas, USA.

A 7-year-old neutered male domestic shorthair cat was presented with chronic lameness in the right forelimb. A cystic bony lesion was identified in the distal right humerus and amputation was performed. The epiphyseal trabecular bones of the capitulum and trochlea was replaced by a tan to pink, expansile mass that was surrounded by a thin rim of cortical bone. Read More

Afr Health Sci 2019 Jun;19(2):2294-2301

Department of Orthopaedic Surgery, Groote Schuur Hospital, Cape Town, South Africa.

Background: Osteoblastomas (OTB) with co-existent aneurysmal bone cysts (ABC) of the spine are extremely rare and more so in the lumbar spine. To the authors' knowledge, only one case of lumbar spine involvement has been reported in a paediatric patient.

Objectives: To highlight diagnostic challenges and surgical management of co-existent lumbar OTB-ACB in a child. Read More

Genet Test Mol Biomarkers 2019 Nov 22;23(11):807-814. Epub 2019 Oct 22.

Department of Ultrasound, Shandong University Qilu Hospital, Jinan, Shandong, China.

The gene programmed cell death 5 () has recently been characterized as a tumor suppressor gene and is believed to be an important prognostic cancer marker; it is frequently involved in neoplastic transformation and apoptosis of tumor cells. Several studies have demonstrated a decrease or loss of expression of in certain tumors. However, the relevance of expression in human osteoclastoma and its clinicopathological significance have not been extensively studied. Read More

Am J Surg Pathol 2019 12;43(12):1661-1667

Royal National Orthopaedic Hospital, Stanmore.

Osteoblastoma and osteoid osteoma together are the most frequent benign bone-forming tumor, arbitrarily separated by size. In some instances, it can be difficult to differentiate osteoblastoma from osteosarcoma. Following our recent description of FOS gene rearrangement in these tumors, the aim of this study is to evaluate the value of immunohistochemistry in osteoid osteoma, osteoblastoma, and osteosarcoma for diagnostic purposes. Read More

Neurocirugia (Astur) 2020 May - Jun;31(3):146-150. Epub 2019 Sep 2.

Servicio de Traumatología y Cirugía Ortopédica, Hospital Universitario Badajoz, Badajoz, España. Electronic address:

We report an uncommon case of osteoid osteoma recurring as an aggressive osteoblastoma of the spine. A 15-years-old male consulted in our department with long-term painful scoliosis. The CT-scans and MRI revealed a sclerotic bone forming tumor of 7mm diameter consistent with a osteoid osteoma. Read More

Cancer Genomics Proteomics 2019 Sep-Oct;16(5):361-368

Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, the Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

Background/aim: Epithelioid osteoblastoma is a rare benign tumor of the bone. Its pathogenesis is unknown and little is known regarding its genetic features.

Materials And Methods: Cytogenetic, RNA sequencing, reverse transcription polymerase chain reaction (RT-PCR), genomic PCR, and Sanger sequencing analyses were performed on an epithelioid osteoblastoma. Read More

Int J Hyperthermia 2019 ;36(1):768-775

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila , L'Aquila , Italy.

Interventional radiology, thanks to its low invasiveness and possibility to reduce the average time for the patients to come back to their normal activity, is becoming more and more promising and diffused in multiple fields. Employed without needles, MRgFUS is probably the less invasive techniques among the ones belonging to the field of interventional radiology. To evaluate safety and effectiveness of MRgFUS in the treatment of a rare and benign, though disabling, bone lesion: intra-articular osteoblastoma. Read More

Int J Surg Case Rep 2019 1;62:9-13. Epub 2019 Aug 1.

Clinical Oncology, Baghdad Radiotherapy and Nuclear Medicine Center, Medical City Complex, Bab Al Muadham, 10047, Baghdad, Iraq. Electronic address:

Introduction: An osteoid osteoma is a benign bone neoplasm with limited growth potential, characterized by significant nocturnal pain that usually responds to non-steroidal anti-inflammatory drugs (NSAIDs). The tumor may occur in any part of the skeleton, most commonly in the lower extremities and vertebrae.

Presentation Of Case: A 46-year-old female was diagnosed with a rare case of an intra-articular variant of osteoid osteoma, involving the articular eminence and glenoid fossa of the temporo-mandibular joint (TMJ). Read More

Rev Bras Ortop (Sao Paulo) 2019 Apr 10;54(2):219-222. Epub 2019 May 10.

Departamento de Cirurgia Ortopédica, Hospital de São João, Faculdade de Medicina, Universidade do Porto, Porto, Portugal.

Osteoblastoma is a rare benign primary bone tumor. It accounts for 3% of benign and 1% of all primary bone tumors. The treatment goal is complete surgical resection. Read More

AJR Am J Roentgenol 2019 11 16;213(5):1157-1162. Epub 2019 Jul 16.

Service d'Imagerie Interventionnelle, Hôpitaux Universitaires de Strasbourg, 1, Pl de l'Hopital, 67000 Strasbourg, France.

The aim of this observational study was to assess safety and clinical outcomes of percutaneous image-guided cryoablation (CA) to treat osteoblastomas (OBs) at various osseous sites. A retrospective search was performed to identify patients presenting with painful OBs who underwent CA at the University Hospitals of Strasbourg between March 2007 and December 2018. Ten patients (seven men, three women; median age, 21 years old) were identified and included. Read More

Anticancer Drugs 2019 08;30(7):e0769

Pharmaceutical Microbiology, Faculty of Pharmacy.

Neurokinin-1 receptor (NK1R) antagonists are known for their anxiolytic, antiemetic, anticancer, and anti-inflammatory effects. Aprepitant is used in vomiting and nausea, which are the most common side-effects of patients undergoing chemotherapy for cancer. L-733,060 has been shown to have anxiolytic and antidepressant effects in animal studies and anticancer effect in in-vitro studies. Read More

World Neurosurg 2019 Oct 27;130:e487-e497. Epub 2019 Jun 27.

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

Objective: Extradural subtemporal keyhole approach could provide adequate removal for some specific middle skull base tumors. The combination of endoscopy and keyhole technique might further help to minimize the complications and provide optimal surgical visualization. Here, a series of attempts with endoscopy by mini-invasive subtemporal extradural approach for 5 middle skull base tumors were successfully achieved. Read More

Ann Diagn Pathol 2019 Aug 13;41:116-123. Epub 2019 Jun 13.

Department of Radiology, Hacettepe University, Ankara, Turkey.

Pseudomyogenic hemangioendothelioma (PHE) is an uncommon mesenchymal tumor of intermediate malignant potential with characteristic clinicopathologic and genetic features. Although bone involvement accompanies nearly one-fourth of reported cases of soft tissue PHEs, primary intraosseous PHE is rare. Herein, we report five cases of primary intraosseous PHEs. Read More

Neuroradiology 2019 Aug 3;61(8):935-942. Epub 2019 Jun 3.

Institute of Diagnostic and Interventional Radiology, Paediatric Radiology and Neuroradiology, University Medical Centre Rostock, Ernst-Heydemann-Str. 6, 18057, Rostock, Germany.

Purpose: To evaluate technical success and long-term outcome of CT-guided radiofrequency ablation (RFA) of spinal osteoid osteomas (OO) and osteoblastomas (OB) in six different European centres.

Methods: Eighty-seven patients with spinal OO (77) or OB (10) were treated with CT-guided RFA, after three-dimensional CT-guided access planning. Patient's long-term outcome was assessed by clinical examination and questionnaire-based evaluation including 10-point visual analogue scales (VAS) regarding the effect of RFA on severity of pain and limitations of daily activities. Read More

Pan Afr Med J 2019 16;32:24. Epub 2019 Jan 16.

Service ORL et Chirurgie Cervico-Faciale, CHU Habib Bourguiba, 3029 Sfax, Tunisie.

Osteoblastoma is a rare benign bone tumor, accounting for 1% of all bone tumors. It mainly occurs in the long bones, more rarely in the jaws. Osteoblastoma of the jaws mainly involves the mandible while nasosinusal involvement is very rare. Read More

Cureus 2019 Mar 12;11(3):e4239. Epub 2019 Mar 12.

Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, USA.

Osteoid osteoma is a benign primary bone tumor of unknown etiology that occurs most commonly in males during adolescence and early adulthood. Osteoid osteoma affects the spine in 20% of cases, and may cause spinal deformity, stiffness, and pain that may sometimes be worst at night. We present a novel description of a partial laminectomy with cement augmentation after resection of an osteoid osteoma. Read More