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Clin Case Rep 2021 May 31;9(5):e04094. Epub 2021 Mar 31.

Department of Obstetrics and Gynecology Medical University of Vienna Vienna Austria.

Extraosseous osteoblastoma of the breast, a rare disease, was diagnosed in a prepubertal girl. After tumor excision, the patient recovered well and an optimal cosmetic result was achieved. Interdisciplinary discussions about the case are essential. Read More

J Orthop Sci 2021 May 25. Epub 2021 May 25.

IRCCS Azienda Ospedaliera Universitaria di Bologna, Bologna, Italy.

Background: The aim of this study was to evaluate the results of different treatments for pelvic Osteoblastoma (OB).

Methods: We retrospectively evaluated 34 patients affected by primary pelvic OB from 3 oncologic referral centers. Patients with a minimum follow-up of 24 months were included. Read More

Acta Ortop Mex 2020 Nov-Dec;34(6):422-425

Ortopedia y Traumatología, Hospital Ángeles Mocel. Ciudad de México. México.

Introduction: Osteoblastoma is a benign, aggressive and rare osteoblastic tumor. Its most common location is in later elements of the spine and sacrum. The cuboid presentation is exceptional. Read More

Semin Musculoskelet Radiol 2021 Feb 21;25(1):176-183. Epub 2021 May 21.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

Interventional radiology procedures have been proven to be as effective as traditional surgery but usually are characterized by lower morbidity rates. In this article, the most diffuse IR treatments for pediatric lesions are reviewed with the aim of describing main advantages and drawbacks. Ablation procedures (in particular RFA and MRgFUS) are widely used for the management of osteoid osteoma and osteoblastoma whereas intracystic injection of methylprednisolone acetate is performed for simple bone cysts. Read More

Radiol Case Rep 2021 Jul 30;16(7):1633-1636. Epub 2021 Apr 30.

Department of Radiology, the First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China.

Osteoblastoma is a rare benign osseous neoplasm that accounts for 1%-3% of all primary bone tumors. Osteoblastomas can involve any part of the skeleton, but mainly occurs in the spine and other long bones, rarely in extra-skeletal areas. Extra-skeletal osteoblastomas arise from tissues outside of the bone, and only a few cases have been reported previously. Read More

J Hand Surg Am 2021 Apr 8. Epub 2021 Apr 8.

Department of Pathology, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India.

Osteoblastomas are rare, benign, bone-forming neoplasms that represent less than 1% of all bone tumors and occur mostly in people aged 10 to 30 years. In long bones, the metadiaphyseal region tends to be most commonly affected. However, to the best of our knowledge, only 11 cases have been reported to occur in the distal radius. Read More

Neurospine 2021 Mar 31;18(1):245-249. Epub 2021 Mar 31.

Department of Imaging Services and Interventional Radiology, G. Kuppuswamy Naidu Memorial Hospital, Coimbatore, India.

Anterior surgical approaches to the cervical spinal pathology have become a frequently used technique. Anterior cervical spine surgeries are generally considered to be safe with low incidence of neurological complications. Vertebral artery (VA) injuries are infrequent during an anterior cervical spine approach but can be devastating. Read More

Semin Ultrasound CT MR 2021 Apr 29;42(2):134-149. Epub 2020 Aug 29.

Department of Musculoskeletal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.

We present a review of several bone (osteoid)-forming tumors including enostosis, osteoid osteoma, osteoblastoma, and osteosarcoma. These entities were chosen because they are reasonably common-neither seen every day nor rare. When applicable, recent information about the lesions is included. Read More

JBJS Case Connect 2021 04 2;11(2). Epub 2021 Apr 2.

Department of Pathology, School of Medicine, The University of Jordan, Amman, Jordan.

Case: A 25-year-old man presented with progressive pain and swelling of the left foot for 4 years. The images showed a contrast-enhanced mixed lesion (osteolytic and blastic) of the first metatarsal bone with surrounding soft-tissue edema. The differential diagnoses favored chronic osteomyelitis or neoplasia, most likely benign. Read More

Cureus 2021 Feb 26;13(2):e13565. Epub 2021 Feb 26.

Medical Sciences, Keele University, Keele, GBR.

Background Bone tumours of the talus are a rare cause of ankle pain. This study aims to provide additional clinical clarity regarding the presentation and management of a minimally researched topic. Methods Sixteen patients were diagnosed with bone tumour of the talus between 2002 and 2020 following referral for ankle pain. Read More

J Craniofac Surg 2021 Mar-Apr 01;32(2):e144-e145

Department of Otorhinolaryngology, University of Health Sciences Turkey, Kartal Dr. Lutfi Kirdar Research and Training Hospital, Istanbul, Turkey.

Abstract: Osteoblastoma is a benign bone tumor with a slow growing and local aggressive nature. This tumor type is usually localized in the cervical vertebra and rarely involves laryngeal cartilage structures. Very few osteoblastoma cases have been reported in the literature. Read More

Radiol Case Rep 2021 Apr 15;16(4):961-963. Epub 2021 Feb 15.

Radiology Department, Military Hospital Mohammed V, Rabat, Morocco.

Osteoblastoma is a rare benign tumor arising predominantly in the vertebrae or long tubular bones. Its naso-sinusian origin is rare and can be responsible for ophthalmological complications [1]. We report the case of 19-yeaold patient admitted to the Ophthalmology department for progressive right exophthalmia and ptosis evolving over 8 months. Read More

Gen Dent 2021 Mar-Apr;69(2):60-63

Osteoblastoma is a rare benign osteoblastic tumor accounting for less than 1% of all bone tumors; approximately 10% to 12% of cases occur in the maxillofacial skeleton. This case report describes the clinical, imaging, and histopathologic findings of an atypical osteoblastoma occurring in the mandible of a 60-year-old man. The characteristics of the lesion and the differential diagnosis from other bone pathoses are reviewed. Read More

J Pediatr Orthop 2021 Apr;41(4):227-235

Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, China.

Background: Primary benign osseous tumors and tumor-like lesions at the sacrum are rare in the pediatric population and exact surgical strategy is still unclear. In this study, we evaluate the outcome for pediatric patients with benign tumors and tumor-like lesions at the sacrum who were receiving surgical treatment according to our proposed surgical strategy and classification.

Methods: We analyzed 49 pediatric patients with sacral benign tumors or tumor-like lesions aged 18 years and below from 2005 to 2018. Read More

Am J Surg Pathol 2021 05;45(5):690-693

Bone Tumour Reference Centre, Institute of Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.

Cementoblastomas are rare odontogenic tumors developing in close proximity to the roots of teeth. Due to their striking morphologic resemblance to osteoblastomas of the peripheral skeleton, we set out to determine whether cementoblastomas harbor the same FOS rearrangements with overexpression of c-FOS as has recently been described for osteoblastomas. In total, 16 cementoblastomas were analyzed for FOS expression by immunohistochemistry and for FOS rearrangements by fluorescence in situ hybridization (FISH). Read More

Am J Case Rep 2021 Feb 8;22:e928548. Epub 2021 Feb 8.

Department of Thoracic Surgery, Ruhr District Thoracic Center in Herne, University of Duisburg-Essen Academic Teaching Hospital, Herne, Germany.

BACKGROUND Osteoblastoma is a very rare bone tumor accounting for 1% of all bone tumors. Most of the time it involves the spine and long bones and it involves the ribs very rarely. While osteoblastoma occurrence in the first rib has been reported, causing neurogenic thoracic outlet syndrome (TOS) has never been reported. Read More

Calcif Tissue Int 2021 06 8;108(6):819-824. Epub 2021 Feb 8.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Camurati-Engelmann disease (CED) is a rare, progressive diaphyseal dysplasia characterized as diaphyseal hyperostosis and sclerosis of the long bones. Corticosteroids, bisphosphonates, and losartan have been reported to be effective systemic medications used to reduce CED symptoms. There are no reports of osteoblastoma in patients with CED, and osteoblastoma in the distal radius is rare. Read More

Life Sci 2021 Feb 2:118993. Epub 2021 Feb 2.

Luzhou City Hospital of Traditional Chinese Medicine, Luzhou, China.. Electronic address:

Objective: To study the proapoptotic effect of ligustilide on osteoblastoma (OS) and the relative related molecular mechanism.

Methods And Materials: An MTT was used to examine the proliferation of OS cells, and Flow cytometry was used to analyze apoptosis and the cell cycle. Western blotting was used to detect the signaling pathway of apoptosis, and immunohistochemical (IH) staining was used to detect the apoptosis status of OS cells. Read More

Virchows Arch 2021 Jan 28. Epub 2021 Jan 28.

Department of Pathology, Azienda Ospedaliera di Padova, Padua, Italy.

The aim of this study is to assess the usefulness of beta-catenin immunohistochemical expression in the differential diagnosis of osteoid-producing primary tumors of bone. Seventy cases of osteoid-producing tumors of bone (24 conventional osteosarcomas, 18 osteoblastomas, 13 osteoblastoma-like osteosarcomas, 10 chondroblastomas, and 5 chondroblastoma-like osteosarcomas) diagnosed at Istituto Ortopedico Rizzoli were reviewed and evaluated for the intensity, extension, and subcellular distribution of immunohistochemical expression of beta-catenin. A majority of cases (73%, 51 cases) exhibited cytoplasmic and/or membranous positivity in varied degrees of intensity and proportion of positive cells, in the absence of nuclear staining. Read More

J Orthop Case Rep 2020 Sep;10(6):18-22

Spine Surgery Unit, Department of Surgery, Bambino Gesù Children's Hospital, IRCCS, Piazza sant'Onofrio 4, 00191, Rome, Italy.

Introduction: Osteoblastomas are primary bone tumors, rarer than osteoid osteomas, and <10% of these lesions occurs in the spine. Aneurysmal bone cysts (ABCs) are rare, benign lesion of the bone and approximately 8-30% of ABCs arise in the spine, mostly in the thoracic and the lumbar regions. The association between them is quite rare in the general population. Read More

Orbit 2021 Jan 11:1-4. Epub 2021 Jan 11.

Department of Ophthalmology & Visual Sciences, University of Adelaide, North Terrace Australia.

Osteoblastoma is a rare benign bone tumour. It represents 1% of all primary bone tumours. Common locations are the vertebral column and long bones of the extremities. Read More

Cureus 2020 Dec 2;12(12):e11838. Epub 2020 Dec 2.

Orthopaedics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, IND.

The critical biomechanical importance of talus and nonspecific clinical features of talus lesion warrants a meticulous diagnostic work-up for specific management, particularly when the talus lesion is associated with concomitant soft tissue and joint abnormalities. We present a rare case of osteoblastoma of talus with concomitant tenosynovitis of tibialis anterior, ankle joint effusion, varicose vein and moderate distal arterial stenosis. Read More

SAGE Open Med Case Rep 2020 6;8:2050313X20978022. Epub 2020 Dec 6.

Department of Orthopaedic Surgery, Yokohama City University, Yokohama, Japan.

Osteoblastoma is a relatively rare benign bone-forming tumor accounting for less than 1% of all bone tumors. This report describes a patient with an osteoblastoma in the femoral head complicated by coexistence of femoroacetabular impingement. A 25-year-old male rugby football player complained of severe right hip pain after an injury during rugby practice. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 May 4;131(5):572-581. Epub 2020 Nov 4.

Department of Pathology, Rambam Medical Center, Haifa, Israel; The Ruth and Bruce Rappaport Faculty of Medicine, Haifa, Israel.

Objective: Special AT-rich binding protein 2 (SATB2) is an immunohistochemical marker for osteoblast differentiation. Our aim was to investigate SATB2 expression in oral osteosarcoma and other bone-producing oral tumors/reactive lesions to evaluate its usefulness as a diagnostic marker.

Study Design: A total of 74 intraosseous and soft tissue bone-producing surgical samples and 10 samples of reactive bone tissue were stained with SATB2, including osteosarcoma/chondrosarcoma (n = 16), fibro-osseous lesions (n = 42), central giant cell granuloma (n = 6), osteoblastoma (n = 1), and gingival lesions (n = 9). Read More

Insights Imaging 2020 Nov 23;11(1):122. Epub 2020 Nov 23.

Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, People's Republic of China.

Objective: To investigate the values of multimodal imaging approaches in the diagnosis of spinal osteoblastomas with an emphasis on MRI findings.

Materials And Methods: We retrospectively evaluated the imaging findings of 35 patients with spinal osteoblastomas. The imaging methods included radiography, whole-body bone scintigraphy (WBBS), CT and MRI. Read More

World Neurosurg 2021 02 18;146:171-176. Epub 2020 Nov 18.

Department of Neurosurgery, Narayana Health, Bengaluru, India.

Background: Craniovertebral junction (CVJ) hydatid disease, although rare, forms an important differential diagnosis of CVJ bony pathologies, especially in endemic areas due to the sheer volume of cases presented there. The authors report a rare case of CVJ hydatid disease mimicking a bony expansile tumor on imaging.

Case Description: A 21-year-old woman presented with a left-sided neck tilt and pain for 3 months, intermittent low-grade fever, and features of high cervical myelopathy (Nurick grade II). Read More

Acta Cytol 2021 12;65(1):75-87. Epub 2020 Nov 12.

Department of Orthopaedics, Nizams Institute of Medical Sciences, Hyderabad, India.

Aim: The aim is to study the utility of fine-needle aspiration cytology (FNAC) in preoperative diagnosis of bone lesions in correlation with radiological and histopathological findings and to determine the spectrum and morphological features of various bone lesions on FNAC.

Materials And Methods: A total of 275 cases of bone lesions were studied by FNAC over a period of 3 years. 196 procedures were performed by pathologists, and 107 procedures were guided. Read More

Pediatr Neurosurg 2020 11;55(5):280-288. Epub 2020 Nov 11.

Department of Orthopedic Surgery, Singapore General Hospital, Singapore, Singapore.

Introduction: Osteoblastoma is a primary benign tumour which commonly presents in the younger population during the second decade of life. However, more aggressive osteoblastomas may present with features of aneurysmal bone cyst, and these can occur at uncommon locations.

Case Presentation: We report the case of a 12-year-old child having an osteoblastoma on the left side of T11 with secondary aneurysmal bone cyst presenting with neurological deficits and myelopathic symptoms. Read More

J Pharm Bioallied Sci 2020 Aug 28;12(Suppl 1):S640-S643. Epub 2020 Aug 28.

Department of Pediatric and Preventive dentistry, Malla Reddy Institute of Dental Sciences, Hyderabad, Telangana, India.

Osteoblastoma is considered as a bone tumor, which is benign and arises from non-odontogenic epithelium. This condition is quite rare in children and very few cases of osteoblastoma are reported. The case report describes osteoblastoma affecting mandible in an 8-year-old boy. Read More

Br J Neurosurg 2020 Nov 3:1-5. Epub 2020 Nov 3.

Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, Japan.

Purpose: Osteoid osteoma occasionally occur in the spine, but their malignant transformation is not common. We present an extremely rare case of the malignant transformation of an osteoid osteoma to high-grade osteosarcoma that formed in the pedicle and spread to the lateral mass of the cervical spine.

Case Presentation: We report the case of an 18-year-old man who suffered from neck pain as an initial symptom. Read More