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Dent J (Basel) 2022 Jun 10;10(6). Epub 2022 Jun 10.

Department of Pathological Anatomy, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia.

Background: Mineralized lesions of the jaws are often found incidentally on radiographs and computed tomography. Most of them are benign, and only a few rare cases are associated with malignant transformation. However, there is little clinical data on successful rehabilitation with implants in patients with mineralized lesions. Read More

Front Surg 2022 6;9:838235. Epub 2022 Jun 6.

Department of Orthopaedics, Peking University Third Hospital, Beijing, China.

Osteoblastoma (OB) is a benign bone tumor with aggressive behavior and a tendency for local recurrence. The appropriate surgical strategy for spinal OB remains unclear. This retrospective study aimed to verify the clinical efficacy and safety of intralesional marginal resection of OB in the mobile spine. Read More

J Clin Imaging Sci 2022 2;12:21. Epub 2022 May 2.

Department of Radiology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.

The performance of preoperative embolization on a spinal tumor can be a useful adjunctive procedure that minimizes blood loss and complications, particularly for both metastatic and non-metastatic hypervascular tumors. We discuss two cases of hypervascular spinal tumors that were successfully treated with preoperative embolization and surgery. The first patient was an 18-year-old man who presented with cervical and shoulder pain for two months without paralysis or weakness. Read More

Cureus 2022 May 13;14(5):e24956. Epub 2022 May 13.

Department of Oral and Maxillofacial Surgery, National and Kapodistrian University of Athens, Dental School, Athens, GRC.

Background/Aim Oral epithelia demonstrate a broad spectrum of pre-cancerous, cancerous, and benign lesions. The aim of this study was to record and analyze the prevalence of various oral and intraosseous lesions, highlighting malignancies that are hard to clinically identify as such too. Materials and methods A series of 536 oral lesions were collected covering a period of 8. Read More

J Neurosurg 2022 05 13:1-11. Epub 2022 May 13.

Objective: Concerns about the approach-related morbidity of the extradural anterior petrosal approach (EAPA) have been raised, especially regarding temporal lobe and venous injuries, hearing impairment, facial nerve palsy, cerebrospinal fluid fistula, and seizures. There is lack in the literature of studies with detailed analysis of surgical complications. The authors have presented a large series of patients who were treated with EAPA, focusing on complications and their avoidance. Read More

SAGE Open Med 2022 22;10:20503121221094199. Epub 2022 Apr 22.

Department of Orthopedics and Traumatology, Marmara University Pendik Training and Research Hospital, İstanbul, Turkey.

Objectives: The aim of this study is to present the clinical, oncological, and functional results of locally aggressive benign bone tumors treated with extended intralesional curettage without the use of adjuvant in a tertiary orthopedic oncology center.

Method: A total of 172 patients treated with surgical curettage and high-speed burrs for the diagnosis of aneurysmal bone cyst, giant cell tumor, osteoblastoma, chondroblastoma, and chondromyxoid fibroma were included in the study. Demographic, radiological, and clinical data of the patients were analyzed. Read More

J Orthop Sci 2022 Apr 22. Epub 2022 Apr 22.

Division of Orthopedic Surgery, Department of Sensory and Motor Organs, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan.

Pathologe 2022 May 25;43(3):174-182. Epub 2022 Apr 25.

Gerhard-Domagk-Institut für Pathologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Deutschland.

Osteoclastic giant cells represent a common cellular component of lesions arising in bone. Highlighting this morphological finding, the current WHO classification of bone tumors defines a diagnostic group comprising aneurysmal bone cyst, giant cell tumor of bone and non-ossifying fibroma, which may display morphologic similarities while being distinct with regard to molecular and biological features. Starting with these tumors - putting a focus on lesions arising in bone - this article gives a survey of other (chondrogenic and osteogenic) tumors that frequently contain osteoclastic giant cells, which may, particularly in small biopsies, enter differential diagnosis. Read More

J Orthop Case Rep 2021 Nov;11(11):1-5

Department of Orthopaedics, Sunshine Multispeciality Hospital, Secunderabad, Telangana, India.

Introduction: Osteoblastoma is a rare benign bone-forming tumor but causes considerable morbidity if left untreated. Among them, osteoblastoma of cuboid is very rarely seen and hence poses considerable diagnostic and therapeutic challenges especially when it mimics features of tuberculosis of foot.

Case Report: This case report describes a rare case of cuboid osteoblastoma of the right foot in a 24-year-old female who was initially treated as TB foot elsewhere and presented to our outpatient department with non-resolving pain affecting her daily activities. Read More

J Clin Med 2022 Apr 2;11(7). Epub 2022 Apr 2.

Division of Radiology, Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.

The family of painful osteocytic tumors includes osteoblastomas and osteoid osteomas-these lesions are considered benign, but they could produce a significant painful symptomatology. Usually, people affected are between 20 s and 30 s. When symptomatic, an effective treatment is mandatory for the management of these lesions to allow for a ful quality of life. Read More

Mod Pathol 2022 Mar 28. Epub 2022 Mar 28.

Bone Tumor Reference Center at the Institute for Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.

Rearrangements of the transcription factors FOS and FOSB have recently been identified as the genetic driver event underlying osteoid osteoma and osteoblastoma. Nuclear overexpression of FOS and FOSB have since then emerged as a reliable surrogate marker despite limitations in specificity and sensitivity. Indeed, osteosarcoma can infrequently show nuclear FOS expression and a small fraction of osteoblastomas seem to arise independent of FOS/FOSB rearrangements. Read More

Int J Surg Case Rep 2022 Apr 12;93:106940. Epub 2022 Mar 12.

Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. Electronic address:

Introduction And Importance: Chondromyxoid fibroma is a rare benign cartilaginous neoplasm, a mixture of benign cartilage and fibrous and myxoid tissue. It usually affects young people, commonly in the second and third decades of life with male being predominant. Differential diagnosess in chondromyxoid fibroma, are giant cell tumor, bone cyst, enchondroma, osteoblastoma, and low-grade chondrosarcoma. Read More

Hum Pathol 2022 Jul 23;125:68-78. Epub 2022 Mar 23.

Department of Pathology, Hospital for Special Surgery, New York, NY, 10021, USA.

Seventeen cases of epithelioid osteoblastoma were reviewed. The tumors most commonly arose from the vertebrae (7 cases), followed by the mandible (3), sacrum (2), bones of the foot (2), and femur, rib, and scapula (1 each). Patients' ages ranged from 5 to 33 years. Read More

Dent Res J (Isfahan) 2022 28;19:13. Epub 2022 Feb 28.

Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Osteoblastoma (OSB) is an uncommon (3% of benign and 1% of all) primary bone neoplasm with extremely rare occurrence in head and neck, especially the maxillary bone region. OSB of the jaw mainly involves the mandible bone. We report a 10-month-old male who was admitted to the hospital because of a mass in the right maxillary jaw region. Read More

Case Rep Dent 2022 8;2022:7623855. Epub 2022 Mar 8.

Department of Oral Medicine, School of Dentistry, University of Washington, Box 356370, 1959 NE Pacific St, Seattle, WA 98195, USA.

Osteoblastoma and osteoid osteoma are rare benign neoplasms of the jaws. We reviewed current literature surrounding the ongoing debate over similarities and differences of osteoblastoma and osteoid osteoma and present two cases. Both cases are well-demarcated mixed radiodensity mandibular lesions with histological features of osteoblastoma. Read More

Quant Imaging Med Surg 2022 Mar;12(3):1988-2001

Department of Radiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.

Background: This study evaluated the clinical characteristics and imaging findings of 112 patients with irregular and flat bone osteosarcoma (IFBO).

Methods: The age, gender, location, tumor size, density and signal intensity, osteoid matrix, periosteal reaction, and histological subtypes were analyzed for 112 patients with IFBO.

Results: A total of 112 patients with IFBO, including 64 males and 48 females, with a mean age of 34. Read More

Ann Pathol 2022 04 18;42(3):208-213. Epub 2022 Feb 18.

Département de pathologie, IUCT-Oncopole, 1, avenue Joliot-Curie, 31059 Toulouse cedex 9, France; Eq19. ONCOSARC CRCT, UMR 1037 Inserm/UT3, ERL 5294 CNRS, Toulouse, France. Electronic address:

Histol Histopathol 2022 Feb 17:18438. Epub 2022 Feb 17.

Department of Pediatrics, Peking University First Hospital，Beijing, China.

Background: Hydrogen sulfide (H₂S) is a novel gas transmitter signaling molecule. H₂S is synthesized by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST). There have been no reports about the roles of these enzymes in osteosarcoma and its metastases. Read More

Zhonghua Kou Qiang Yi Xue Za Zhi 2022 Feb;57(2):189-191

Department of Pathology, School and Hospital of Stomatology, China Medical University, Liaoning Prorincial key Laboratory of Oral Diseases, Shenyang 110002, China.

Indian J Nucl Med 2021 Oct-Dec;36(4):443-444. Epub 2021 Dec 15.

Department of Radiology, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Osteoblastoma accounts for approximately 1% of all primary bone tumors. We report F18-fluorodeoxyglucose positron emission tomography/computed tomography (F18-FDG PET/CT) findings of an osteoblastoma in the rib of a 20-month-old girl child, who had fever with pain in the right shoulder for 4 months. This lesion was initially judged as a malignant bone tumor but a biopsy revealed it to be an osteoblastoma. Read More

APMIS 2022 Apr 18;130(4):206-214. Epub 2022 Feb 18.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

The use of denosumab to treat giant cell tumors of bone (GCT) and other giant cell-containing bone tumors has become more common. While the clinicopathologic features of denosumab-treated giant cell tumors of bone have been well-illustrated, descriptions of other denosumab-treated bone tumors are very limited. Surgical pathology files of two institutions and consultation files from two authors were searched for denosumab-treated aneurysmal bone cysts and denosumab-treated osteoblastomas. Read More

Clin Nucl Med 2022 May;47(5):456-457

Department of Nuclear Medicine, Qinghai Province People's Hospital, Xining, Qinghai, China.

Abstract: We present a case of rib osteoblastoma in a patient with NK/T cell lymphoma. Osteoblastoma was incidentally found in a 63-year-old man in the axillary segment of the fifth rib and was misdiagnosed as lymphomatous involvement on staging 18F-FDG PET/CT. The radiological features in the CT component of PET/CT were atypical. Read More

Otol Neurotol 2022 02;43(2):e276-e278

Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.

This report describes osteoblastoma of the temporal bone found on a well-child visit. The relevant clinical, radiographic, and histologic features are described. The tumor was completely resected via a transtemporal approach. Read More

J Clin Med 2021 Dec 29;11(1). Epub 2021 Dec 29.

Department of Emergency and Interventional Radiology, San Salvatore Hospital, 67100 L'Aquila, Italy.

Previous studies suggest that interventional ablative procedures on bone lesions may weaken the bone, especially when performed through the needle approach. Our purpose was to evaluate, through Computed Tomography (CT), the effects of Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) ablation on painful osteoid osteomas and osteoblastomas in terms of bone density and morphological changes. We retrospectively evaluated patients treated at our institution with MRgFUS for superficial, painful osteoid osteoma or osteoblastoma during the last 9 years. Read More

J Clin Med 2021 Dec 27;11(1). Epub 2021 Dec 27.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

Osteoblastoma (OB) and osteoid osteoma (OO) are benign bone-forming tumors, with nearly identical basic microscopic features. The main difference is dimension (OO has usually a nidus measuring <2 cm in diameter). In addition, OB is biologically more active than OO, with a tendency to grow in size. Read More

Imaging Sci Dent 2021 Dec 11;51(4):455-460. Epub 2021 Aug 11.

Division of Diagnostic Imaging, Department of Prosthodontics and Digital Technology, School of Dental Medicine, State University of New York at Stony Brook, New York, USA.

This report presents a rare case of maxillary osteoblastoma in a 17-year-old female. The patient presented with dull pain and facial asymmetry inferior to the left zygoma. An intraoral examination found a painless swelling on the buccal gingival tissue in the left posterior maxilla. Read More

J Clin Med 2021 Dec 7;10(24). Epub 2021 Dec 7.

Department of Emergency and Interventional Radiology, San Salvatore Hospital, 67100 L'Aquila, Italy.

Osteoblastoma (OB) is a rare, benign bone tumor, accounting for 1% of all primary bone tumors, which occurs usually in childhood and adolescence. OB is histologically and clinically similar to osteoid osteoma (OO), but it differs in size. It is biologically more aggressive and can infiltrate extraskeletal tissues. Read More

Spinal Cord Ser Cases 2021 11 16;7(1):99. Epub 2021 Nov 16.

Department of Neurosurgery, SS Antonio e Biagio e Cesare Arrigo Alessandria Hospital, Alessandria, Italy.

Introduction: Aggressive osteoblastoma (AO) represents a rare tumor with borderline features between benign osteoblastoma and osteosarcoma. Having a local aggressive behavior without metastasizing attitude, radical excision is a mainstay treatment. Conversely, spine fusion technique is still debated. Read More

Surg Pathol Clin 2021 Dec 7;14(4):549-565. Epub 2021 Oct 7.

Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK; Radiology Department, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Greater London HA7 4LP, UK.

Benign bone-forming tumors comprise osteomas, osteoid osteomas, and osteoblastomas. Osteomas affect a wide age range and are usually discovered incidentally. They occur predominantly in the craniofacial skeleton and are classically composed of compact bone. Read More