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World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital.

Neurosurgery 2018 Nov 27. Epub 2018 Nov 27.

Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Background: Osteoblastoma (OBL) in the mobile spine is a benign tumor with aggressive potential. There is not much published information on OBL of the mobile spine as a result of rarity of the disease. There are controversies over the aggressive subtype and prognostic factors of the condition. Read More

Eur J Nucl Med Mol Imaging 2018 Oct 19. Epub 2018 Oct 19.

Department of Radiology and Nuclear Medicine, Cantonal Hospital Lucerne, Lucerne, Switzerland.

Osteoid osteoma is a painful, benign, osteoblastic lesion that occurs in younger patients and affects the extremities or the axial skeleton. While plain film findings may suggest the diagnosis, in complex anatomical regions such as the spine, pelvis, wrist and foot advanced imaging modalities are often required. A typical nidus surrounded by sclerosis or cortical thickening characterizes osteoid osteoma on plain radiography and CT. Read More

Medicine (Baltimore) 2018 Oct;97(42):e12803

Department of General Surgery, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou, China.

Rationale: Osteoblastoma is an uncommon primary bone tumor that involves any part of the skeleton. But its occurrence in the skull is extremely rare.

Patients Concerns: A 30-year-old female was admitted to our hospital, because of the mass in the right frontal region with the history of headache for 3 years without nausea or vomiting. Read More

Radiologia 2018 Sep 28. Epub 2018 Sep 28.

Servicio de Diagnóstico por Imágenes, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Sternal tumours are rare in children. The differential diagnoses include a wide spectrum of benign (from bone cyst to osteoblastoma, osteochondroma and fibrous displasia) and malignant tumours (Ewing's sarcoma, chondrosarcoma rhabdomyosarcoma), inflammatory lesions and infectious processes. The SELSTOC (Self Limiting Sternal Tumours of Childhood) are entities of non-specific origin, they are self-limiting and characterised by a rapidly growing tumour that disappears spontaneously with no history of trauma or active infection. Read More

Clin Sarcoma Res 2018 5;8:18. Epub 2018 Sep 5.

1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal and Sciences, Nuffield Orthopaedic Centre, University of Oxford, Oxford, OX3 7HE UK.

Background: Periostin is a matricellular protein that is expressed in bone and joint tissues. To determine the expression of periostin in primary bone tumours and to assess whether it plays a role in tumour progression, we carried out immunohistochemistry and ELISA for periostin in a range of neoplastic and non-neoplastic bone and joint lesions.

Methods: 140 formalin-fixed paraffin-embedded sections of bone tumours and tumour-like lesions were stained by an indirect immunoperoxidase technique with a polyclonal anti-periostin antibody. Read More

Cytojournal 2018 27;15:20. Epub 2018 Aug 27.

Department of Orthopaedics, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India.

Osteoblastoma is a rare bone tumor mostly affecting the young adults and commonly involving the spinal cord and long bones. Talus is the uncommon site of presentation, and if involved, then the neck is more commonly involved than the body of talus. The cytological diagnosis of osteoblastoma is limited, and to the best of our knowledge, its fine-needle aspiration (FNA) in the talus has still not been reported in the literature. Read More

Orthopade 2018 Sep 7. Epub 2018 Sep 7.

Department of Orthopedics, Artificial Joints Engineering and Technology Research Center of Jiangxi Province and Multidisciplinary Therapy Center of Musculoskeletal Tumor, The First Affiliated Hospital of Nanchang University, 330006, Nangchang, Jiangxi, China.

Background: An osteoblastoma is a rare benign bone tumor characterized by formation of osteoid tissue and primitive bone and occurs more often in men than in women. They are often secondary to an osteoid osteoma and can be located at any site on the skeleton. Lesions generally involve the posterior elements of the spine, such as the pedicle and the lamina. Read More

J Oral Biol Craniofac Res 2018 Sep-Dec;8(3):203-205. Epub 2017 Jul 1.

Department of Oral Pathology, Government Dental College and Hospital, St. George Hospital Campus, Near Chhatrapati Shivaji Terminus Area, Fort, Mumbai, Maharashtra 400001, India.

Radiolucent lesions of Temporomandibular Joint (TMJ) represent a diagnostic challenge and a treatment conundrum. Biopsy of the lesions is technically difficult owing to their complex anatomy. The Differential Diagnosis (DD) includes a wide array of lesions including Simple Bone Cyst, Ameloblastoma, Central Giant Cell Granuloma, Hemangioma, Osteoblastoma, Osteochondroma, Chondroblastoma, Chondrosarcoma, Neurofibroma and metastatic malignant lesions though none has a specific predilection for TMJ. Read More

Ann Otol Rhinol Laryngol 2018 Nov 6;127(11):864-869. Epub 2018 Sep 6.

2 Department of Otolaryngology- Head & Neck Surgery, University of Washington, Seattle, Washington, USA.

Objective: Describe a novel treatment approach to a rare bony neoplasm in the frontal sinus.

Study Design: Case report.

Methods: Retrospective chart review of an osteoblastoma of the frontal sinuses complicated by a right orbital mucocle. Read More

Histopathology 2018 Aug 28. Epub 2018 Aug 28.

Department of Pathology, IRCCS Rizzoli Orthopaedic Institute, Bologna, Italy.

Aims: Osteoblastoma-like osteosarcoma is a rare variant of osteosarcoma (1% of all osteosarcomas), histologically similar to osteoblastoma. In the current World Health Organisation (WHO) classification, osteoblastoma-like osteosarcoma is classified within the group of conventional (high-grade) osteosarcomas. However, several published cases have been actually regarded as low-grade malignant tumours. Read More

Am J Rhinol Allergy 2018 Nov 22;32(6):465-472. Epub 2018 Aug 22.

3 Rick and Tina Caruso Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California.

Background: Pediatric benign paranasal sinus osteoneogenic tumors have previously been difficult to treat due to the surgical constraints of the developing skull. Progression may lead to intracranial complications or orbital and optic nerve compression.

Objective: To assess the presentation and management of benign paranasal sinus osteoneogenic tumors. Read More

Acta Orthop Traumatol Turc 2018 Aug 9. Epub 2018 Aug 9.

Bağcılar Training and Research Hospital, Department of Radiology, İstanbul, Turkey. Electronic address:

We report a 14-year-old boy who presented with pain in the left foot and ankle for about 9 months. The clinical symptoms of the patient suggested complex regional pain syndrome (CRPS). The radiographs and magnetic resonance imaging studies ravealed a bone tumor in the talus, consistent with an osteoblastoma. Read More

Pan Afr Med J 2018 20;29:164. Epub 2018 Mar 20.

Service de Chirurgie Orthopédique, CHU Rabat, Hopital Ibn Sina, Université Mohammed V, Souissi, Maroc.

Osteoblastoma is a rare benign bone tumor occurring in adults younger than 30 years, with a clear predominance in men. It mainly occurs at the level of the spine and of the diaphysis in long bones. It occurs exceptionally in the ankle. Read More

Acta Biomed 2018 Jun 7;89(2):269-273. Epub 2018 Jun 7.

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We reported the case of a 22 year-old boy who suffered a periosteal osteoblastoma of the distal fibula. The radiographic features of our case did not correlate with the majority of periosteal osteoblastomas of the long bones reported in the literature and were identical to a periosteal aneurysmal bone cyst. Periosteal osteoblastoma is a very rare tumor with a wide range of clinical and radiological features, showing in 15% of cases association with secondary aneurysmal bone cyst. Read More

J Clin Orthop Trauma 2018 Jun 18;9(Suppl 2):S21-S25. Epub 2017 Sep 18.

Department of Radiology, University College of Medical Sciences and Guru Teg Bahadur hospital, Dilshad Garden, Delhi, 110095, India.

Osteoblastoma is a rare tumor and represents about 0.8% of all bone tumors. The aggressive variant is even rarer and difficult to diagnose. Read More

Nat Commun 2018 06 1;9(1):2150. Epub 2018 Jun 1.

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, UK.

The transcription factor FOS has long been implicated in the pathogenesis of bone tumours, following the discovery that the viral homologue, v-fos, caused osteosarcoma in laboratory mice. However, mutations of FOS have not been found in human bone-forming tumours. Here, we report recurrent rearrangement of FOS and its paralogue, FOSB, in the most common benign tumours of bone, osteoblastoma and osteoid osteoma. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2017 Sep;31(9):1069-1072

Department of Bone Tumor Surgery, Orthopedics Center, the First Affiliated Hospital of Xinjiang Medical University, Urumchi Xinjiang, 830054,

Objective: To discuss the effect of three-dimensional (3D) printing individualized model and guide plate in bone tumor surgery.

Methods: Between October 2015 and December 2016, 3D printing individualized model and guide plate for making preoperative surgical planning and intraoperative treatment were used in 5 patients of bone tumor. All the patients were male, with a median age of 32 years (range, 9-58 years). Read More

Chin J Dent Res 2018;21(2):147-149

Benign osteoblastoma is a rare bone tumour characterised histologically by the production of woven bone spicules, which are bordered by prominent osteoblasts. It mainly affects young adults. We report a rare case of benign osteoblastoma of the maxilla in a 7-year-old boy who presented with a painful swelling on the left hard palate. Read More

Oral Oncol 2018 Jul 18;82:198-199. Epub 2018 May 18.

Oral & Maxillofacial Surgery Department, Mid-Essex Hospitals Trust, Chelmsford, UK.

Sichuan Da Xue Xue Bao Yi Xue Ban 2018 Jan;49(1):129-132

Department of Orthopaedics,West China Hospital,Sichuan University,Chengdu 610041,China.

Objective: To investigate the surgical techniques and mid-term efficacy of reconstruction for proximal femur with allograft-prosthetic composite (APC) .

Methods: Fifteen patients who underwent uncemented APC reconstruction of proximal femur after bone tumor resection were retrospectively evaluated. Image and physical examinations were taken on the 1st,3rd,6th,9th and 12th month after surgery and every 6 months thereafter to assess union condition,greater trochanteric bone absorption and myodynamia of abductors. Read More

J Surg Oncol 2018 Jun 3;117(8):1786-1798. Epub 2018 May 3.

Queen Elizabeth II Health Sciences Center, Halifax Infirmary, Dalhousie University, Halifax, Nova Scotia, Canada.

Bone tumors are relatively rare in the foot and ankle region. Many of them present as cystic lesions on plain films. Due to the relative rarity of these lesions and the complex anatomy of the foot and ankle region, identification of such lesions is often delayed or they get misdiagnosed and mismanaged. Read More

Future Oncol 2018 Dec 25;14(28):2945-2955. Epub 2018 Apr 25.

Department of Biotechnology & Applied Clinical Science, University of L'Aquila, L'Aquila, Italy.

Interventional radiology has experienced an exponential growth in the last years. Nowadays it is possible to treat painful benign lesions or metastases with optimal results in terms of pain management and disease control. Among the benign lesions, osteoid osteoma is the most frequently treated with minimal invasive techniques and the results are excellent. Read More

Am J Rhinol Allergy 2018 Mar 23;32(2):82-84. Epub 2018 Mar 23.

2 Rush Sinus Program, Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois, and.

Background: With the exception of osteomas, bone neoplasms that originate in the sinonasal cavity are seldom diagnosed on preoperative imaging due to a lack of characteristic radiographic features. Here we described the unusual occurrence of an osteoblastoma in the paranasal sinuses, and we drew focus to its salient imaging features. A highly unique imaging sign was indicated, and its pathologic basis was explained, with concurrent review of the literature. Read More

Am J Surg Pathol 2018 Jun;42(6):744-749

Division of Pathology.

Osteogenic sarcoma (OS) is the most common malignant bone tumor in children and adolescents. Despite advances in molecular genetic characterization of pediatric and adult tumors, the diagnosis of OS still depends almost entirely on light microscopy. The lack of consistent genetic changes in OS has greatly hindered the development of any diagnostic molecular test. Read More

Skeletal Radiol 2018 Oct 10;47(10):1443-1448. Epub 2018 Mar 10.

John Theurer Cancer Center, Hackensack University Medical Center, 20 Prospect Avenue, Suite 501, Hackensack, NJ, 07601, USA.

We report a rare case of giant periosteal osteoblastoma in the femur of a 21-year-old male. The patient presented with a painful, firm, non-tender mass in his left thigh. The pain was worse at night and was temporarily relieved with NSAIDS. Read More

Head Neck Pathol 2018 Mar 5. Epub 2018 Mar 5.

Consultant Oral and Maxillofacial Surgeon, Monash Health, Melbourne, VIC, Australia.

The diagnosis of osteomas in the paediatric population can pose a challenge to pathologists in excluding malignant bony tumours. We present the case of a 10-year old male presenting with a large left mandibular radiopaque lesion. This paper discusses the case of a central osteoma with osteoblastoma-like features, literature review, differential diagnosis of radiopaque lesions of the maxilla and mandible as well as a detailed discussion of the pathology of the lesion. Read More

Skeletal Radiol 2018 Aug 15;47(8):1183-1189. Epub 2018 Feb 15.

Complejo Hospitalario Univeritario de Ferrol, A Coruña, Spain.

Osteoblastomatosis (OBLT), also referred to as multifocal osteoblastoma (OB), is an unusual and recently described entity consisting of multifocal tumors histologically consistent with osteoblastoma and osteoid osteoma (OO) but radiologically mimicking a vascular bone lesion. OBLT treatment is based on aggressive procedures, such as amputation, en bloc resection, and chemotherapy. Only one previously reported case was successfully treated following a multimodal approach consisting of curettage, cryotherapy, intravenous bisphosphonates, and radiofrequency ablation. Read More

World Neurosurg 2018 Apr 5;112:243-246. Epub 2018 Feb 5.

Department of Neurosurgery, Policlinico San Martino, University of Genoa, Genoa, Italy.

Background: Osteoblastoma is a benign bone-forming tumor, sometimes locally invasive, that may involve any bone. The highest incidence is between 20 and 30 years of age, and there are no cases described in the elderly.

Methods: We report a case of an elderly patient with a lesion in the lumbar spine in which osteoblastoma diagnosis was made. Read More

Eur Spine J 2018 Jul 29;27(Suppl 3):477-482. Epub 2018 Jan 29.

Orthopaedics Department, Centro Hospitalar Lisboa Norte, University Hospital of Santa Maria, Avenida Professor Egas Moniz, 1649-035, Lisbon, Portugal.

Introduction: The anterior elements of the spine, particularly the odontoid processes, are a rare location for osteoblastomas. Pseudomalignant osteoblastomas are themselves rare histologic types and are also extremely rare in this location. Most osteoblastomas are Enneking stage 2 lesions; less frequently, they can be more aggressive with extra-capsular extension (Enneking stage 3). Read More

Eur Spine J 2018 Jul 22;27(Suppl 3):446-452. Epub 2018 Jan 22.

Division of Spinal Surgery, University of Oxford, Oxford, England, UK.

Purpose: To present a case of aggressive sacral osteoblastoma (OB) treated with neoadjuvant denosumab therapy and en bloc resection.

Methods: Case report of a 14-year-old male with an aggressive OB affecting the superior articular process of the left first sacral segment. The lesion was lytic and metabolically active and involved the left-sided posterior elements of S1-S3 with extension into the spinal canal, affecting the left S1, S2, S3, S4 and S5 nerve roots. Read More

Lancet Oncol 2018 01;19(1):26

Division of Paleopathology, University of Pisa, Pisa, Italy.

BMC Musculoskelet Disord 2017 Dec 19;18(1):538. Epub 2017 Dec 19.

Department of Orthopedic Surgery, West China Hospital, Sichuan University, No. 37 GuoXue Road, Chengdu, Sichuan, 610041, China.

Background: Osteoblastoma is a rare and benign tumor which requires early diagnosis and surgical excision. Scoliosis is a common presentation following osteoblastoma. It is considered due to pain-provoked muscle spasm on the side of the lesion. Read More

Cureus 2017 Sep 30;9(9):e1733. Epub 2017 Sep 30.

Montreal Neurological Institute, McGill University Health Centre.

We report a rare case of an aggressive osteoblastoma (OB) involving the calvaria and infiltrating the dura, a finding that was not previously reported in the literature. A 50-year-old man presented with a progressive mass in the left frontoparietal skull with headaches and a six-month history of sudden mass growth. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a large skull lesion with areas of hemorrhage, calcification, restricted diffusion, and enhancement. Read More

BMJ Case Rep 2017 Nov 23;2017. Epub 2017 Nov 23.

Department of Oral and Maxillofacial Pathology, Goa Dental College and Hospital, Bambolim, Goa, India.

Cementoblastoma is a benign odontogenic neoplasm accounting for less than 0.69%-8% of all odontogenic tumours and is characterised by the presence of sheets of cementum-like tissue demonstrating large number of reversal lines. It shows an unlimited growth potential and a recurrence rate as high as 37. Read More

Medicine (Baltimore) 2017 Nov;96(46):e8685

aDepartment of Otolaryngology-Head and Neck Surgery, Chonbuk National University Hospital bResearch Institute of Clinical Medicine, Chonbuk National University, Jeonju, Republic of Korea.

Rationale: Sinonasal osteoblastoma is an extremely rare benign bone-forming tumor.

Patient Concerns: We report 2 extremely rare cases of sinonasal osteoblastoma in the middle turbinate.

Diagnoses: The preoperative diagnosis was osteoma in the middle turbinate. Read More

J Calif Dent Assoc 2016 12;44(12):737-40

This case study involves a 22-year-old male who experienced moderate pain in the left side of the mandible for two months. He was diagnosed with an osteoblastoma and treated with local excision, curettage and extraction of the involved teeth. Radiographic follow-up indicated that the site healed well. Read More

Oper Neurosurg (Hagerstown) 2018 Aug;15(2):184-193

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: The use of intraoperative navigation during microscope cases can be limited when attention needs to be divided between the operative field and the navigation screens. Heads-up display (HUD), also referred to as augmented reality, permits visualization of navigation information during surgery workflow.

Objective: To detail our initial experience with HUD. Read More

Handchir Mikrochir Plast Chir 2017 10 13;49(5):350-351. Epub 2017 Sep 13.

Surgeon 2018 Jun 12;16(3):156-162. Epub 2017 Aug 12.

Department of Orthopaedic Oncology, Glasgow Royal Infirmary, Castle Street, Glasgow, G4 0ET, UK. Electronic address:

Background And Purpose: Osteoid osteoma is an infrequent but debilitating benign bone lesion which can be successfully managed by percutaneous radiofrequency ablation (RFA). There are few studies investigating the efficacy and follow-up of this treatment. An arbitrary upper limit of 15 mm has been used to differentiate between osteoid osteoma and osteoblastoma with surgery used for lesions above this limit. Read More

Surg Pathol Clin 2017 Sep 29;10(3):513-535. Epub 2017 Jun 29.

Department of Pathology, Miller School of Medicine, University of Miami, 1400 Northwest 12th Avenue, Miami, FL 33136, USA. Electronic address:

Bone-forming tumors are defined by neoplastic cells that differentiate along the lines of osteoblasts that deposit neoplastic bone. The morphology and biological spectrum of bone-forming tumors is broad, and their accurate diagnosis requires the careful correlation of their clinical, morphologic, and radiologic characteristics. Immunohistochemical and molecular analyses have an important role in select instances. Read More

Mol Clin Oncol 2017 Aug 29;7(2):237-240. Epub 2017 Jun 29.

Department of Neurological Surgery, Wakayama Medical University, Wakayama 641-0012, Japan.

Osteoblastomas are benign bone tumors that produce prostaglandin and promote inflammation. The aim of the present study was to describe the clinical and radiological characteristics of a pediatric osteoblastoma case over an 8-month postoperative follow-up. The case involved an 11-year-old female patient with normal somatic development, presenting with a chief complaint of sleep disturbance. Read More

J Tissue Eng Regen Med 2018 Feb 26;12(2):516-528. Epub 2017 Nov 26.

Department of Molecular Science and Technology, Ajou University, Suwon, Korea.

Recently, computer-designed three-dimensional (3D) printing techniques have emerged as an active research area with almost unlimited possibilities. In this study, we used a computer-designed 3D scaffold to drive new bone formation in a bone defect. Poly-L-lactide (PLLA) and bioactive β-tricalcium phosphate (TCP) were simply mixed to prepare ink. Read More

World Neurosurg 2017 Oct 12;106:1051.e1-1051.e4. Epub 2017 Jul 12.

Division of Neurosurgery, Department of Neurosciences, Jewish General Hospital, McGill University Health Center, Montreal, Quebec, Canada.

Background: Epithelioid "aggressive" osteoblastoma (EOB) is a rare and more aggressive subtype of osteoblastoma (OB) with a higher recurrence rate, greater risk of malignant transformation, larger size, and greater intraoperative blood loss. The present case report illustrates that preoperative angioembolization of an EOB can be safely performed with low intraoperative blood loss.

Case Description: A 21-year-old male patient presented to our institution with a 4-month history of neck discomfort, radicular pain in the proximal right arm, and mild weakness of the right biceps and triceps muscles. Read More

J Neurosurg Spine 2017 Sep 7;27(3):321-327. Epub 2017 Jul 7.

Division of Spine, Department of Orthopedics, University of British Columbia, and the Combined Neurosurgical and Orthopedic Spine Program at Vancouver Coastal Health, Vancouver, British Columbia, Canada.

OBJECTIVE Osteoblastoma is a rare primary benign bone tumor with a predilection for the spinal column. Although of benign origin, osteoblastomas tend to behave more aggressively clinically than other benign tumors. Because of the low incidence of osteoblastomas, evidence-based treatment guidelines and high-quality research are lacking, which has resulted in inconsistent treatment. Read More

Eur J Orthop Surg Traumatol 2017 Aug 20;27(6):787-795. Epub 2017 Jun 20.

Department of Orthopedics and Orthopedic Oncology, University of Padova, Via Giustiniani 3, 35128, Padua, Italy.

Purpose: To analyze the clinical and radiographic characteristics, treatment, and outcome of patients with elbow osteoblastoma.

Patients And Methods: We present 13 patients (7 males and 6 females; mean age, 28 years) diagnosed and treated for an elbow osteoblastoma from 1975 to 2012. Mean follow-up was 29 months (range 12-60 months). Read More

Br J Cancer 2017 Jul 20;117(3):398-408. Epub 2017 Jun 20.

University College London Cancer Institute, 72 Huntley Street, London WC1E 6BT, UK.

Background: The most prevalent form of bone cancer is osteosarcoma (OS), which is associated with poor prognosis in case of metastases formation. Mice harbouring liver kinase B1 (LKB1) develop osteoblastoma-like tumours. Therefore, we asked whether loss of LKB1 gene has a role in the pathogenesis of human OS. Read More

J Orthop Case Rep 2017 Jan-Feb;7(1):61-64

Department of Oral Pathology, Government Dental College and Hospital, Aurangabad, Maharashtra, India.

Introduction: Osteosarcoma is a malignant mesenchymal tumor whose cancerous cells produce osteoid matrix. It is a common primary malignant bone tumor, representing 23% of total head and neck malignancies. Osteosarcomas of the jaws are rare lesions, representing only 4-7% of all osteosarcomas. Read More

Int J Hyperthermia 2018 05 9;34(3):321-327. Epub 2017 Jun 9.

b Dipartimento di Scienze Cliniche Applicate e Biotecnologiche , Universita degli Studi dell'Aquila , L'Aquila , Italy.

Objective: Osteoblastoma (OB) is a painful, rare, benign bone tumour usually observed in young populations, and this condition involves the spine in up to one-third of cases. We sought to focus on the minimally invasive treatment of spinal OB with radiofrequency ablation (RFA) under computed tomography (CT) guidance. When performed near the spinal cord, surgery can lead to instability of the spine, sometimes requiring additional interventions to stabilise the segments involved, and can cause the precocious onset of arthrosis or other degenerative diseases. Read More

Semin Nucl Med 2017 07 12;47(4):322-351. Epub 2017 Apr 12.

Department of Radiology and Nuclear Medicine, Deventer Ziekenhuis, Deventer, The Netherlands.

Positron emission tomography with the radiotracer F-fluoro-2-deoxy-d-glucose (FDG) plays an important role in the evaluation of bone pathology. However, FDG is not a cancer-specific agent, and knowledge of the differential diagnosis of benign FDG-avid bone alterations that may resemble malignancy is important for correct patient management, including the avoidance of unnecessary additional invasive tests such as bone biopsy. This review summarizes and illustrates the spectrum of benign bone conditions that may be FDG-avid and mimic malignancy, including osteomyelitis, bone lesions due to benign systemic diseases (Brown tumor, Erdheim-Chester disease, Gaucher disease, gout and other types of arthritis, Langerhans cell histiocytosis, and sarcoidosis), benign primary bone lesions (bone cysts, chondroblastoma, chondromyxoid fibroma, desmoplastic fibroma, enchondroma, giant cell tumor and granuloma, hemangioma, nonossifying fibroma, and osteoid osteoma and osteoblastoma), and a group of miscellaneous benign bone conditions (post bone marrow biopsy or harvest status, bone marrow hyperplasia, fibrous dysplasia, fractures, osteonecrosis, Paget disease of bone, particle disease, and Schmorl nodes). Read More