4,041 results match your criteria Osteoarthritis and Cartilage[Journal]


Patient Characteristics Affect Hip Contact Forces during Gait.

Osteoarthritis Cartilage 2019 Feb 14. Epub 2019 Feb 14.

Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; NIHR Leeds Biomedical Research Centre, Leeds, UK. Electronic address:

Objective: To examine hip contact force (HCF), calculated through multibody modelling, in a large total hip replacement (THR) cohort stratified by patient characteristics such as BMI, age and function.

Method: 132 THR patients undertook one motion capture session of gait analysis at a self-selected walking speed. HCFs were then calculated using the AnyBody Modelling System. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.016DOI Listing
February 2019

Diagnosis of calcium pyrophosphate deposition by imaging - current state and challenges remaining.

Authors:
F Becce

Osteoarthritis Cartilage 2019 Feb 8. Epub 2019 Feb 8.

Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.joca.2019.01.015DOI Listing
February 2019
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Diagnostic value of ultrasound in calcium pyrophosphate deposition disease of the knee joint.

Osteoarthritis Cartilage 2019 Feb 6. Epub 2019 Feb 6.

Division of Rheumatology, Department of Internal Medicine, Research Institute of Medical Science, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, South Korea. Electronic address:

Objective: To assess the diagnostic performance of ultrasound (US) for calcium pyrophosphate deposition (CPPD) at the level of menisci, hyaline cartilage (HC), tendons, and synovial fluid (SF) of the knee, and to examine inter- and intra-observer reliability.

Design: We consecutively included patients with knee effusion over a 2-year period (43 patients with CPPD and 131 controls). All patients underwent SF analysis, conventional radiography (CR), and US examination using the Outcome Measures in Rheumatology (OMERACT) definition of the US characteristics of CPPD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584193004
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http://dx.doi.org/10.1016/j.joca.2018.11.013DOI Listing
February 2019
3 Reads

Compositional changes predict morphologic cartilage lesion development - are we one step closer to clinical translation of quantitative MRI?

Authors:
X Li F W Roemer

Osteoarthritis Cartilage 2019 Feb 6. Epub 2019 Feb 6.

Department of Radiology, University of Erlangen-Nuremberg; Erlangen, Germany; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.joca.2019.01.014DOI Listing
February 2019
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Nutrient supply and nucleus pulposus cell function: effects of the transport properties of the cartilage endplate and potential implications for intradiscal biologic therapy.

Osteoarthritis Cartilage 2019 Feb 2. Epub 2019 Feb 2.

Department of Orthopaedic Surgery, University of California San Francisco, USA. Electronic address:

Objective: Intradiscal biologic therapy is a promising strategy for managing intervertebral disc degeneration. However, these therapies require a rich nutrient supply, which may be limited by the transport properties of the cartilage endplate (CEP). This study investigated how fluctuations in CEP transport properties impact nutrient diffusion and disc cell survival and function. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.013DOI Listing
February 2019
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Social & psychological factors associated with oral analgesic use in knee osteoarthritis management.

Osteoarthritis Cartilage 2019 Feb 1. Epub 2019 Feb 1.

College of Medicine and UA Arthritis Center, University of Arizona (UA), Tucson, AZ, USA.

Objective: Determine modifiable social and psychological health factors that are associated with use of oral opioid and non-opioid medications for OA.

Methods: Patients were categorized based on use of the following oral medications: opioids (with/without other oral analgesic treatments), non-opioid analgesics, and no oral analgesic treatment. We used multinomial logistic regression models to estimate adjusted relative risk ratios (RRRs) of using an opioid or a non-opioid analgesic (vs. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.010DOI Listing
February 2019
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A 12-item short form of the Knee injury and Osteoarthritis Outcome Score (KOOS-12): tests of reliability, validity and responsiveness.

Osteoarthritis Cartilage 2019 Feb 1. Epub 2019 Feb 1.

University of Massachusetts Medical School, Worcester, MA, USA; John Ware Research Group, Watertown, MA, USA. Electronic address:

Objective: To evaluate reliability, validity and responsiveness of KOOS-12, a 12-item short form of the 42-item KOOS that provides Pain, Function and Quality of Life (QOL) scale scores and a summary knee impact score.

Design: Data from 1,392 knee osteoarthritis (OA) patients from the FORCE-TJR research cohort who completed KOOS before and 6 and 12 months after total knee replacement (TKR) were analyzed. KOOS-12 includes a pain frequency item and three items measuring pain during increasingly difficult (sitting/lying, walking, stairs) activities; function items about standing, rising from sitting, getting in/out of a car, and twisting/pivoting; and the 4-item KOOS QOL scale. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.011DOI Listing
February 2019
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Clock mutant promotes osteoarthritis by inhibiting the acetylation of NFκB.

Osteoarthritis Cartilage 2019 Feb 2. Epub 2019 Feb 2.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; Research Center on Aging and Medicine, Fudan University, Shanghai 200032, China. Electronic address:

Objectives: To examine the effect of the circadian gene Clock on posttranscriptional function and pro-inflammatory mechanisms in osteoarthritis (OA).

Methods: The cartilage from Clock mutant mice was assessed using histology, (OA) score, and real-time polymerase chain reaction (PCR) quantification of key pro-inflammatory genes. Nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) translocation, posttranslational state and expression levels during day and night conditions were assessed using immunoblot and IP. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.012DOI Listing
February 2019
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Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction.

Osteoarthritis Cartilage 2019 Feb 1. Epub 2019 Feb 1.

Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. Electronic address:

Objective: The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that integrates nutrients to execute cell growth. We hypothesized that mTOR is influential in the intervertebral disc-largest avascular, low-nutrient organ. Our objective was to identify the optimal mTOR inhibitor for treating human degenerative disc disease. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.009DOI Listing
February 2019
2 Reads

Changes in stiffness and biochemical composition of the pericellular matrix as a function of spatial chondrocyte organisation in osteoarthritic cartilage.

Osteoarthritis Cartilage 2019 Jan 31. Epub 2019 Jan 31.

Laboratory of Cell Biology, Department of Orthopaedic Surgery, University Hospital of Tübingen, Waldhörnlestraße 22, D-72072 Tübingen, Germany; Department of Orthopaedic Surgery, University Hospital of Tübingen, Hoppe-Seyler-Strasse 3, D-72076 Tübingen, Germany. Electronic address:

Objective: During osteoarthritis (OA), chondrocytes seem to change their spatial arrangement from single to double strings, small and big clusters. Since the pericellular matrix (PCM) appears to degrade alongside this reorganisation, it has been suggested that spatial patterns act as an image-based biomarker for OA. The aim of this study was to establish the functional relevance of spatial organisation in articular cartilage. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.008DOI Listing
January 2019
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Intra-articular corticosteroids and the risk of knee osteoarthritis progression: results from the Osteoarthritis Initiative.

Osteoarthritis Cartilage 2019 Jan 29. Epub 2019 Jan 29.

Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Objective: A recent randomized clinical trial reported that repeated intra-articular corticosteroids (IACs) were associated with a greater cartilage loss. This study aimed to examine the relation of IACs to knee radiographic osteoarthritis (ROA) progression in a real-world setting.

Design: A cohort that initiated IACs and a comparison cohort without IACs from participants with mild to moderate knee ROA in the Osteoarthritis Initiative (OAI) were assembled (from 0-month to 48-month). Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.007DOI Listing
January 2019
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Fibronectin fragment inhibits xylosyltransferase-1 expression by regulating Sp1/Sp3- dependent transcription in articular chondrocytes.

Osteoarthritis Cartilage 2019 Jan 24. Epub 2019 Jan 24.

Division of Rheumatology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi, 431-070, South Korea; Institute for Skeletal Aging, Hallym University, Chunchon 200-702, South Korea. Electronic address:

Objective: We investigated the effects of 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) on xylosyltransferase-1 (XT-1), an essential anabolic enzyme that catalyzes the initial and rate-determining step in glycosaminoglycan chain synthesis, in human primary chondrocytes.

Methods: Proteoglycan and XT-1 expression in cartilage tissue was analyzed using safranin O staining and immunohistochemistry. The effects of 29-kDa FN-f on XT-1 expression and its relevant signaling pathway were analyzed by quantitative real-time-PCR, immunoblotting, chromatin immunoprecipitation, and immunoprecipitation assays. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.006DOI Listing
January 2019
2 Reads

Opioid use in knee or hip osteoarthritis: a region-wide population-based cohort study.

Osteoarthritis Cartilage 2019 Jan 22. Epub 2019 Jan 22.

Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Lund, Sweden; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA.

Objective: To quantify opioid use in knee and hip osteoarthritis (OA) patients, and to estimate the proportion of opioids in the population attributable to OA patients.

Design: Population-based cohort study.

Methods: We included 751,579 residents in southern Sweden, aged ≥35 years in 2015. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.005DOI Listing
January 2019
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Health professionals and students encounter multi-level barriers to implementing high-value osteoarthritis care: a multi-national study.

Osteoarthritis Cartilage 2019 Jan 19. Epub 2019 Jan 19.

School of Physiotherapy and Exercise Science, Curtin University, Australia. Electronic address:

Objective: Consistent evidence-practice gaps in osteoarthritis (OA) care are observed in primary care settings globally. Building workforce capacity to deliver high-value care requires a contemporary understanding of barriers to care delivery. We aimed to explore barriers to OA care delivery among clinicians and students. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.024DOI Listing
January 2019
2 Reads

Midfoot osteoarthritis: potential phenotypes and their associations with demographic, symptomatic and clinical characteristics.

Osteoarthritis Cartilage 2019 Jan 17. Epub 2019 Jan 17.

Arthritis Research UK Primary Care Centre, Research Institute for Primary Care and Health Sciences, Keele University, Staffordshire, UK; Haywood Academic Rheumatology Centre, Midlands Partnership NHS Foundation Trust, Haywood Hospital, Staffordshire, UK.

Objective: To investigate the demographic, symptomatic, clinical and structural foot characteristics associated with potential phenotypes of midfoot osteoarthritis (OA).

Design: Cross-sectional study of 533 community-dwelling adults aged ≥50 years with foot pain in the past year. Health questionnaires and clinical assessments of symptoms, foot structure and function were undertaken. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.022DOI Listing
January 2019
5 Reads

Sagittal plane walking biomechanics in individuals with knee osteoarthritis after quadriceps strengthening.

Osteoarthritis Cartilage 2019 Jan 18. Epub 2019 Jan 18.

University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

Objective: To compare sagittal walking gait biomechanics between participants with knee osteoarthritis (KOA) who increased quadriceps strength following a lower-extremity strengthening intervention (responders) and those who did not increase strength following the same strengthening protocol (non-responders) both at baseline and following the lower extremity strengthening protocol.

Design: Fifty-three participants with radiographic KOA (47% female, 62.3 ± 7. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.026DOI Listing
January 2019
2 Reads

Model-based pain and function outcome trajectory types for patients undergoing knee arthroplasty: a secondary analysis from a randomized clinical trial.

Osteoarthritis Cartilage 2019 Jan 17. Epub 2019 Jan 17.

Departments of Physical Therapy, Orthopaedic Surgery and Rheumatology, Virginia Commonwealth University, Richmond, VA, USA.

Objective: Knee arthroplasty (KA) is an effective surgical procedure. However, clinical studies suggest that a considerable number of patients continue to experience substantial pain and functional loss following surgical recovery. We aimed to estimate pain and function outcome trajectory types for persons undergoing KA, and to determine the relationship between pain and function trajectory types, and pre-surgery predictors of trajectory types. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584193002
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http://dx.doi.org/10.1016/j.joca.2019.01.004DOI Listing
January 2019
4 Reads

The evolving large-strain shear responses of progressively osteoarthritic human cartilage.

Osteoarthritis Cartilage 2019 Jan 18. Epub 2019 Jan 18.

University of Connecticut, Department of Mechanical Engineering, Storrs, CT, USA; University of Connecticut, Department of Biomedical Engineering, Storrs, CT, USA. Electronic address:

Objective: The composition and structure of articular cartilage evolves during the development and progression of osteoarthritis (OA) resulting in changing mechanical responses. We aimed to assess the evolution of the intrinsic, large-strain mechanics of human articular cartilage-governed by collagen and proteoglycan and their interactions-during the progression of OA.

Design: We completed quasi-static, large-strain shear tests on 64 specimens from ten donors undergoing total knee arthroplasty (TKA), and quantified the corresponding state of OA (OARSI grade), structural integrity (PLM score), and composition (glycosaminoglycan and collagen content). Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.025DOI Listing
January 2019
2 Reads

Marked and rapid change of bone shape in acutely ACL injured knees - an exploratory analysis of the Kanon trial.

Osteoarthritis Cartilage 2019 Jan 14. Epub 2019 Jan 14.

Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopedics, Lund, Sweden.

Background: To investigate changes in knee 3D bone shape over the first 5 years after acute anterior cruciate ligament (ACL) injury in participants of the randomized controlled KANON-trial.

Methods: Serial MR images over 5 years from 121 young (32 women, mean age 26.1 years) adults with an acute ACL tear in a previously un-injured knee were analyzed using statistical shape models for bone. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584193001
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http://dx.doi.org/10.1016/j.joca.2018.12.021DOI Listing
January 2019
6 Reads

Relationship between alignment and cartilage thickness in patients with non-traumatic and post-traumatic knee osteoarthritis.

Osteoarthritis Cartilage 2019 Jan 14. Epub 2019 Jan 14.

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Canada. Electronic address:

Objective: To compare cartilage thickness between patients with non-traumatic and post-traumatic knee osteoarthritis (OA) and healthy controls and to determine if disease severity and alignment impact these differences.

Design: Participants with non-traumatic (n = 22) and post-traumatic (n = 19) knee OA, and healthy controls (n = 22) were recruited for this cross-sectional study. Participants underwent 3T magnetic resonance imaging (T1-weighted, 3D sagittal gradient echo sequence) and cartilage thickness was determined in four regions: medial and lateral condyle, and medial and lateral plateau. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584193001
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http://dx.doi.org/10.1016/j.joca.2019.01.002DOI Listing
January 2019
3 Reads

Potential diagnostic value of a type X collagen neo-epitope biomarker for knee osteoarthritis.

Osteoarthritis Cartilage 2019 Jan 14. Epub 2019 Jan 14.

Rheumatology, Biomarkers and Research, Nordic Bioscience, Herlev, Denmark. Electronic address:

Objective: Phenotypic changes of chondrocytes toward hypertrophy might be fundamental in the pathogenesis of osteoarthritis (OA), of which type X collagen (Col10) is a well-known marker. The purpose was to develop a specific immunoassay for blood quantification of a newly identified neo-epitope of type Col10 to assess its diagnostic value for radiographic knee OA.

Methods: A neo-epitope of Col10 was identified in urine samples from OA patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584193001
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http://dx.doi.org/10.1016/j.joca.2019.01.001DOI Listing
January 2019
5 Reads

Ambulatory activity interacts with common risk factors for osteoarthritis to modify increases in MRI-detected osteophytes.

Osteoarthritis Cartilage 2019 Jan 14. Epub 2019 Jan 14.

Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; Department of Rheumatology and Immunology, Arthritis Research Institute, The First Affiliate Hospital of Anhui Medical University, Hefei, China. Electronic address:

Objective: To investigate the longitudinal association between objectively measured ambulatory activity (AA) and knee MRI-detected osteophytes (OPs), and to test whether this relationship was modified by common risk factors for OA including sex, obesity, disease severity and knee injury history.

Methods: 408 community-dwelling adults aged 51-81 years were assessed at baseline and 2.7 years. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.023DOI Listing
January 2019
1 Read

The natural initiation and progression of osteoarthritis in the anterior cruciate ligament deficient feline knee.

Osteoarthritis Cartilage 2019 Jan 11. Epub 2019 Jan 11.

Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Objective: The aim of this study was to document the natural history of development and long-term progression of osteoarthritis (OA) in the feline knee after minimally invasive anterior cruciate ligament (ACL) transection.

Design: ACL transections of the left knee joint of 14 skeletally mature cats were performed. Radiographic scores, tibiofemoral and patellofemoral joint space and anterior tibial translation were assessed before, immediately and every 3 months after ACL transection (longest follow-up: 93 months). Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.003DOI Listing
January 2019
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Tibial plateau fractures are associated with a long-lasting increased risk of total knee arthroplasty a matched cohort study of 7,950 tibial plateau fractures.

Osteoarthritis Cartilage 2019 Jan 8. Epub 2019 Jan 8.

Department of Occupational Therapy and Physiotherapy, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark.

Objective: This study aims to investigate the risk of total knee replacement (TKR) following tibia plateau fractures. Secondary the study aims to investigate the risk of knee arthroscopy following tibial plateau fractures.

Method: The study was designed as a matched cohort study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584193000
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http://dx.doi.org/10.1016/j.joca.2018.12.020DOI Listing
January 2019
3 Reads

Nature vs nurture in knee osteoarthritis - the importance of age, sex and body mass index.

Osteoarthritis Cartilage 2019 Jan 8. Epub 2019 Jan 8.

Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Clinical Epidemiology Unit, Lund, Sweden; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA. Electronic address:

Objective: (1) To estimate the life-time genetic contribution for knee osteoarthritis (OA) surgery and (2) to explore any differences in the genetic contribution across age, sex and body mass index (BMI).

Methods: We studied the sex-specific genetic contribution to knee OA surgery in a prospective cohort study of 62,490 twins aged 35 years or older with a follow-up period of up to 47 years (10,092 identical and 21,153 non-identical twin pairs, 54% women). To study interactions with age, we graphed the heritabilities over the lifespan for men and women. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.018DOI Listing
January 2019

T1ρ MRI of the talar articular cartilage is increased in those with chronic ankle instability.

Osteoarthritis Cartilage 2019 Jan 8. Epub 2019 Jan 8.

Department of Exercise & Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Objective: To determine if individuals with chronic ankle instability (CAI) demonstrate different talar cartilage T1ρ relaxation times compared to uninjured controls.

Design: Fifteen CAI (21.13 ± 1. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.019DOI Listing
January 2019
1 Read

Identification of long non-coding RNAs expressed in knee and hip osteoarthritic cartilage.

Osteoarthritis Cartilage 2019 Jan 3. Epub 2019 Jan 3.

Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle Upon Tyne, NE1 3BZ, UK. Electronic address:

Objective: Long intergenic non-coding RNAs (lincRNAs) are emerging as key regulators in gene expression; however, little is known about the lincRNA expression changes that occur in osteoarthritis (OA). Here we aimed to define a transcriptome of lncRNAs in OA cartilage, specifically comparing the lincRNA transcriptome of knee and hip cartilage.

Method: RNA-seq was performed on nucleic acid extracted from hip cartilage from patients undergoing joint replacement surgery because of either OA (n = 10) or because of a neck of femur fracture (NOF; n = 6). Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.015DOI Listing
January 2019
1 Read

Relationships between cartilage thickness and subchondral bone mineral density in non-osteoarthritic and severely osteoarthritic knees: In vivo concomitant 3D analysis using CT arthrography.

Osteoarthritis Cartilage 2019 Jan 3. Epub 2019 Jan 3.

Swiss BioMotion Lab, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.

Objective: To test whether subchondral bone mineral density (sBMD) and cartilage thickness (CTh) of femoral condyles are correlated in knees without and with severe medial femorotibial osteoarthritis (OA), using a subregional analysis with computerized tomography (CT) arthrography.

Methods: CT arthrograms of 50 non-OA (18 males, 58.7 (interquartile range (IQR) = 6. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.014DOI Listing
January 2019
4 Reads

Characterisation of peripheral and central components of the rat monoiodoacetate model of Osteoarthritis.

Osteoarthritis Cartilage 2019 Jan 3. Epub 2019 Jan 3.

Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.

Objective: Pain is the main reason patients report Osteoarthritis (OA), yet current analgesics remain relatively ineffective. This study investigated both peripheral and central mechanisms that lead to the development of OA associated chronic pain.

Design: The monoiodoacetate (MIA) model of OA was investigated at early (2-6 days post injection) and late (>14 days post injection) time points. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.017DOI Listing
January 2019
1 Read

Losartan attenuates progression of osteoarthritis in the synovial temporomandibular and knee joints of a chondrodysplasia mouse model through inhibition of TGF-β1 signaling pathway.

Osteoarthritis Cartilage 2019 Jan 3. Epub 2019 Jan 3.

Roseman University of Health Sciences, College of Dental Medicine, South Jordan, UT 84095, USA; Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA.

Objective: Transforming growth factor beta 1 (TGF-β1) is implicated in osteoarthritis (OA). The purpose of this study was to explore the ability of Losartan to inhibit the inflammatory signaling pathway of TGF-β1 observed during osteoarthritic progression in the temporomandibular joint (TMJ) and knee joint using a genetic mouse model.

Methods: A murine OA model displaying the heterozygous chondrodysplasia gene (cho/+), a col11a1 mutation, was used to test this hypothesis. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.016DOI Listing
January 2019
2 Reads

Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis.

Osteoarthritis Cartilage 2018 Dec 28. Epub 2018 Dec 28.

Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, NG5 1PB, UK; Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, Nottingham, UK; Department of Rheumatology, Sherwood Forest Hospitals NHS Foundation Trust, Mansfield Road, Sutton in Ashfield, NG17 4JL, UK; NIHR Nottingham, Biomedical Research Centre, University of Nottingham, UK.

Objective: Osteoarthritis (OA) is a major source of knee pain. Mechanisms of OA knee pain are incompletely understood but include synovial pathology. We aimed to identify molecular expression patterns in the synovium associated with symptomatic knee OA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584183159
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http://dx.doi.org/10.1016/j.joca.2018.12.012DOI Listing
December 2018
1 Read

Osteoarthritis year in review 2018: mechanics.

Osteoarthritis Cartilage 2018 Dec 28. Epub 2018 Dec 28.

Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, USA; Department of Pathology, Duke University School of Medicine, Durham, NC, USA.

Objective: To review recent biomechanics literature focused on the interactions between biomechanics and articular cartilage health, particularly focused on macro-scale and human studies.

Design: A literature search was conducted in PubMed using the search terms (biomechanics AND osteoarthritis) OR (biomechanics AND cartilage) OR (mechanics AND osteoarthritis) OR (mechanics AND cartilage) for publications from April 2017 to April 2018.

Results: Abstracts from the 559 articles generated from the literature search were reviewed. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.011DOI Listing
December 2018
2 Reads

Risk factor heterogeneity for medial and lateral compartment knee osteoarthritis: analysis of two prospective cohorts.

Osteoarthritis Cartilage 2018 Dec 29. Epub 2018 Dec 29.

Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Objective: To evaluate the etiologic heterogeneity between medial and lateral tibiofemoral radiographic osteoarthritis (ROA).

Methods: Knees without medial or lateral tibiofemoral ROA at baseline were followed for 60-month in Multicenter Osteoarthritis Study (MOST) and for 48-month in Osteoarthritis Initiative (OAI). We examined the relation of previously reported risk factors to incident medial and lateral tibiofemoral ROA separately and determined the etiology heterogeneity with a ratio of rate ratios (RRs) (i. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.013DOI Listing
December 2018
3 Reads

Item selection for 12-item short forms of the Knee injury and Osteoarthritis Outcome Score (KOOS-12) and Hip disability and Osteoarthritis Outcome Score (HOOS-12).

Osteoarthritis Cartilage 2018 Dec 26. Epub 2018 Dec 26.

University of Massachusetts Medical School, Worcester, MA, USA; John Ware Research Group, Watertown, MA, USA. Electronic address:

Objective: To develop 12-item short forms (KOOS-12, HOOS-12) of the 42-item Knee injury and Osteoarthritis Outcome Score (KOOS) and 40-item Hip disability and Osteoarthritis Outcome Score (HOOS) that represent the full-length instruments sufficiently to provide joint-specific pain, function and quality of life (QOL) domain and summary joint impact scores. This paper describes KOOS-12 and HOOS-12 item selection. Subsequent papers will examine KOOS-12 and HOOS-12 reliability, validity and responsiveness. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584183158
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http://dx.doi.org/10.1016/j.joca.2018.11.011DOI Listing
December 2018
12 Reads

Articular chondrocytes isolated from the knee and ankle joints of human tissue donors demonstrate similar redox-regulated MAP kinase and Akt signaling.

Osteoarthritis Cartilage 2018 Dec 24. Epub 2018 Dec 24.

Division of Rheumatology, Allergy and Immunology and the Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

Objective: To compare key intracellular redox-regulated signaling pathways in chondrocytes derived from knee joint femoral cartilage and ankle joint talar cartilage in order to determine if differences exist that might contribute to the lower prevalence of ankle osteoarthritis (OA).

Methods: Femoral and talar chondrocytes were treated with HO generators (menadione or 2-3-dimethoxy-1,4-napthoquinone (DMNQ), fragments of fibronectin (FN-f)) to stimulate MAP kinase signaling (MAPK), or with IGF-1 to stimulate the Akt signaling pathway. Hyperoxidation of the peroxiredoxins, used as a measure of redox status, and phosphorylation of proteins pertinent to MAPK (p38, ERK, JNK, c-Jun) and Akt (Akt, PRAS40) signaling cascades were detected by immunoblotting. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.010DOI Listing
December 2018

Osteoarthritis year in review 2018: imaging.

Osteoarthritis Cartilage 2018 Dec 25. Epub 2018 Dec 25.

Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland; Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland. Electronic address:

Purpose: To provide a narrative review of the most relevant original research published in 2017/2018 on osteoarthritis imaging.

Methods: The PubMed database was used to recover all relevant articles pertaining to osteoarthritis and medical imaging published between 1 April 2017 and 31 March 2018. Review articles, case studies and in vitro or animal studies were excluded. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.009DOI Listing
December 2018
3 Reads

The star excursion balance test is a reliable and valid outcome measure for patients with knee osteoarthritis.

Osteoarthritis Cartilage 2018 Dec 24. Epub 2018 Dec 24.

Wolf Orthopaedic Biomechanics Laboratory, Fowler Kennedy Sport Medicine Clinic, University of Western Ontario, London, ON, Canada; Schulich School of Medicine, University of Western Ontario, London, ON, Canada. Electronic address:

Objectives: Despite the recognized importance of neuromuscular exercises, there is currently no widely accepted clinical outcome measure focused on neuromuscular control for patients with knee osteoarthritis (OA). The purposes of the present study were to investigate the test-retest reliability, concurrent validity and longitudinal validity of the star excursion balance test (SEBT) in patients with knee OA.

Design: 74 patients performed the SEBT on two sessions within 7 days, and on a third session after completing 12 weeks of a home exercise program focused on neuromuscular control. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584183158
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http://dx.doi.org/10.1016/j.joca.2018.11.012DOI Listing
December 2018
6 Reads

The impact of painful knee osteoarthritis on mortality: a community-based cohort study with over 24 years of follow-up.

Osteoarthritis Cartilage 2018 Dec 22. Epub 2018 Dec 22.

Thurston Arthritis Research Center, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA; Department of Orthopaedics, University of North Carolina, Chapel Hill, NC, USA; Department of Social Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address:

Objective: To investigate the impact of knee osteoarthritis (OA) and/or knee pain on excess mortality.

Method: We analyzed data from 4,182 participants in a community-based prospective cohort study of African American and Caucasian men and women aged ≥45 years. Participants completed knee radiographs and questionnaires at baseline and at up to three follow-ups to determine knee OA (rOA), knee pain and covariate status. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.008DOI Listing
December 2018
10 Reads

The role of subchondral bone, and its histomorphology, on the dynamic viscoelasticity of cartilage, bone and osteochondral cores.

Osteoarthritis Cartilage 2018 Dec 18. Epub 2018 Dec 18.

Department of Mechanical Engineering, University of Birmingham, United Kingdom. Electronic address:

Objective: Viscoelastic properties of articular cartilage have been characterised at physiological frequencies. However, studies investigating the interaction between cartilage and subchondral bone and the influence of underlying bone histomorphometry on the viscoelasticity of cartilage are lacking.

Method: Dynamic Mechanical Analysis (DMA) has been used to quantify the dynamic viscoelasticity of bovine tibial plateau osteochondral cores, over a frequency sweep from 1 to 88 Hz. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.006DOI Listing
December 2018

Serological biomarker profiles of rapidly progressive osteoarthritis in tanezumab-treated patients.

Osteoarthritis Cartilage 2018 Dec 18. Epub 2018 Dec 18.

Pfizer Inc., 445 Eastern Point Road, Groton, CT 06340, USA. Electronic address:

There is a need for efficacious and safe pain treatments for OA (osteoarthritis). The nerve growth factor (NGF) antibody tanezumab is associated with high efficacy, but when combined with chronic NSAID treatment shows an increased risk of rapidly progressive osteoarthritis (RPOA) in a small group of patients.

Aim: The aim of this study was to phenotype with biochemical biomarkers of bone, cartilage, soft tissue, synovial metabolism OA patients who are at risk of developing RPOA type-2, for both limited and chronic NSAIDs users. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584183155
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http://dx.doi.org/10.1016/j.joca.2018.12.001DOI Listing
December 2018
5 Reads

2-Year outcome from two parallel randomized controlled trials. Reporting considerations.

Osteoarthritis Cartilage 2018 Dec 18. Epub 2018 Dec 18.

INSERM METHODS Team UMR1153, Université Paris Descartes, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10634584183157
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http://dx.doi.org/10.1016/j.joca.2018.10.015DOI Listing
December 2018
4 Reads

Response to Letter to Editor: '2-year outcome from two parallel randomized controlled trials. Reporting considerations'.

Osteoarthritis Cartilage 2018 Dec 17. Epub 2018 Dec 17.

Orthopedic Surgery Research Unit, Aalborg University Hospital, 9000 Aalborg, Denmark; Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, 9220 Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, 9220 Aalborg, Denmark.

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http://dx.doi.org/10.1016/j.joca.2018.12.005DOI Listing
December 2018

Inhibition of early response genes prevents changes in global joint metabolomic profiles in mouse post-traumatic osteoarthritis.

Osteoarthritis Cartilage 2018 Dec 18. Epub 2018 Dec 18.

Department of Orthopaedic Surgery, University of California Davis, Research Building 1 Suite 2000, 4635 Second Avenue, Sacramento, CA 95817, USA. Electronic address:

Objective: Although joint injury itself damages joint tissues, a substantial amount of secondary damage is mediated by the cellular responses to the injury. Cellular responses include the production and activation of proteases (MMPs, ADAMTSs, Cathepsins), and the production of inflammatory cytokines. The trajectory of cellular responses is driven by the transcriptional activation of early response genes, which requires Cdk9-dependent RNA Polymerase II phosphorylation. Read More

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http://dx.doi.org/10.1016/j.joca.2018.11.006DOI Listing
December 2018
5 Reads
4.165 Impact Factor

NGF increases FGF2 expression and promotes endothelial cell migration and tube formation through PI3K/Akt and ERK/MAPK pathways in human chondrocytes.

Osteoarthritis Cartilage 2018 Dec 15. Epub 2018 Dec 15.

Department of Orthopaedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Jiefang Road 88#, Hangzhou 310009, PR China; Orthopaedics Research Institute, Zhejiang University, Jiefang Road 88#, Hangzhou, 310009, PR China. Electronic address:

Objective: Vascular invasion is observed at the osteochondral junction in osteoarthritis (OA). Nerve growth factor (NGF) as an angiogenic factor is expressed in OA. This study is to investigate the effects of NGF on angiogenesis in vitro in human chondrocytes. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.007DOI Listing
December 2018

Incremental clinical effectiveness and cost effectiveness of providing supervised physiotherapy in addition to usual medical care in patients with osteoarthritis of the hip or knee: 2-year results of the MOA randomised controlled trial.

Osteoarthritis Cartilage 2018 Dec 14. Epub 2018 Dec 14.

Department of Physical Therapy, High Point University, High Point, NC, USA. Electronic address:

Objective: To investigate the clinical- and cost-effectiveness at 2-year follow-up of providing individual, supervised exercise physiotherapy and/or manual physiotherapy in addition to usual medical care.

Method: People with hip or knee osteoarthritis meeting the American College of Rheumatology clinical diagnostic criteria were randomised (1:1, concealed, assessor-blinded) to four groups: usual medical care; supervised exercise physiotherapy; manual physiotherapy; or combined exercise and manual physiotherapy. Physiotherapy group participants were provided 10 50-min treatment sessions including booster sessions at 4 and 13 months, in addition to usual care. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.004DOI Listing
December 2018
4 Reads

Ultra-high field magnetic resonance imaging parameter mapping in the posterior horn of ex vivo human menisci.

Osteoarthritis Cartilage 2018 Dec 12. Epub 2018 Dec 12.

Medical Radiation Physics, Department of Translational Medicine, Lund University, Malmö, Sweden; Medical Imaging and Physiology, Skåne University Hospital, Lund, Sweden. Electronic address:

Objective: To investigate the relationship between meniscus magnetic resonance (MR) relaxation parameters and meniscus degradation through quantitative imaging of ex vivo posterior horns of menisci from subjects with and without knee osteoarthritis (OA).

Design: We sampled medial and lateral menisci from ten medial compartment knee OA patients (mean age 63 years) undergoing total knee replacement and from ten deceased donors (references, mean age 51 years). MR relaxation parameters T2*, T2 and T1 of the posterior horn were measured at a 9. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.003DOI Listing
December 2018
2 Reads

Osteoarthritis year in review 2018: biomarkers (biochemical markers).

Osteoarthritis Cartilage 2018 Dec 12. Epub 2018 Dec 12.

Biomarker and Research, Nordic Bioscience, Herlev, Denmark. Electronic address:

Objective: The aim of this narrative review is to summarize important findings from biochemical marker studies relevant to osteoarthritis (OA) in the context of new discoveries and clinical and scientific need.

Design: We conducted a systematic search of electronic medical databases (Embase, Medline, Web of Science, Cochrane central) between 01-03-2017 and 31-03-2018. The search was restricted to human studies, English language and full text available publications while reviews were excluded. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.002DOI Listing
December 2018

Osteoarthritis year in review 2018: rehabilitation and outcomes.

Osteoarthritis Cartilage 2018 Dec 7. Epub 2018 Dec 7.

Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.

Objective: Conduct a systematic review of systematic reviews and randomised controlled trials (RCTs) from the past year evaluating rehabilitation for people with osteoarthritis, and provide narrative synthesis of findings focused on core recommended treatments for osteoarthritis (exercise, education, biomechanical interventions, weight loss).

Design: A comprehensive search strategy was used to search PubMed, EMBASE and Cochrane databases (16 May 2017 to 22 March 2018). Search terms included 'osteoarthritis', 'rehabilitation', 'systematic review', and 'randomised controlled trial'. Read More

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http://dx.doi.org/10.1016/j.joca.2018.11.010DOI Listing
December 2018
1 Read

Patellar tendon enthesis abnormalities and their association with knee pain and structural abnormalities in older adults.

Osteoarthritis Cartilage 2018 Dec 5. Epub 2018 Dec 5.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. Electronic address:

Objective: To describe associations between presence of patellar tendon enthesis (PTE) abnormalities and symptoms, structural abnormalities, and total knee replacement (TKR) in older adult cohort.

Methods: PTE abnormalities (presence of abnormal bone signal and/or bone erosion), were measured on T2-weighted magnetic resonance (MR) images at baseline in 961 community-dwelling older adults. Knee pain and function limitation were assessed using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584183155
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http://dx.doi.org/10.1016/j.joca.2018.11.009DOI Listing
December 2018
10 Reads

MiR-15b is a key regulator of proliferation and apoptosis of chondrocytes from patients with condylar hyperplasia by targeting IGF1, IGF1R and BCL2.

Osteoarthritis Cartilage 2019 Feb 3;27(2):336-346. Epub 2018 Dec 3.

Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei province, China. Electronic address:

Objective: This study aimed to explore potential microRNAs (miRNAs), which participate in the pathological process of condylar hyperplasia (CH) through targeting specific proliferation- and apoptosis- related genes of chondrocytes.

Methods: Insulin-like growth factor 1 (IGF1), IGF1 receptor (IGF1R) and B-cell CLL/lymphoma 2 (BCL2) in CH cartilage were detected by real-time polymerase chain reaction (PCR), Western blot, immunohistochemistry and immunofluorescence. MiRanda and TargetScanS algorithms were used to predict certain miRNAs in CH chondrocytes concurrently modulating the above three genes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584183148
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http://dx.doi.org/10.1016/j.joca.2018.09.010DOI Listing
February 2019
9 Reads