4,066 results match your criteria Osteoarthritis and Cartilage[Journal]


'Acute Flare-Ups' In Patients With, Or At High Risk Of, Knee Osteoarthritis: A Daily Diary Study With Case-Crossover Analysis.

Osteoarthritis Cartilage 2019 Apr 14. Epub 2019 Apr 14.

Clinical Epidemiology, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, UK. Electronic address:

Objective: To determine the natural history of flare-ups in knee osteoarthritis and their relation to physical exposures.

Design: Adults aged ≥45 years with a recent primary care consultation for knee OA/arthralgia completed a daily pen-and-paper diary for up to 3 months, including questions on average knee pain intensity, pain descriptors, other symptoms, activity interference, and selected physical exposures (prolonged kneeling, squatting, climbing stairs, ladders, and moving/lifting heavy objects). Informed by a systematic review, flare-ups were defined a priori. Read More

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http://dx.doi.org/10.1016/j.joca.2019.04.003DOI Listing

Proof of Concept: Hip Joint Damage Occurs at the Zone of Femoroacetabular Impingement (FAI) in an Experimental FAI Sheep Model.

Osteoarthritis Cartilage 2019 Apr 13. Epub 2019 Apr 13.

Department of Orthopaedic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Musculoskeletal Research Unit (MSRU), Equine Hospital, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland; Department of Orthopaedic Surgery and Traumatologie, Cantonal Hospital, University of Fribourg, Switzerland.

Objective: In ovine hips chondrolabral damage as seen in cam-type femoroacetabular impingement (FAI) can be induced via an intertrochanteric varus osteotomy. However, it is yet to proven whether the observed cartilage damage is caused by a dynamic cam type impingement. Thus we asked, (1) whether actual cartilage damage observed after FAI induction in ovine hips occurs at the predicted, computed zone of FAI; (2) whether the extent of cartilage damage increases with ambulation time in this animal model?

Design: In this experimental, controlled, comparative study 20 sheep underwent unilateral FAI induction through an intertrochanteric varus osteotomy. Read More

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http://dx.doi.org/10.1016/j.joca.2019.04.001DOI Listing

In finger osteoarthritis, change in synovitis is associated with change in pain on a joint-level; a longitudinal magnetic resonance imaging study.

Osteoarthritis Cartilage 2019 Apr 9. Epub 2019 Apr 9.

Departments of Rheumatology, Leiden University Medical Center (LUMC), Leiden, the Netherlands; Clinical Epidemiology, Leiden University Medical Center (LUMC), Leiden, the Netherlands. Electronic address:

Objective: To investigate determinants of decrease and increase in joint pain in symptomatic finger osteoarthritis (OA) on magnetic resonance (MR) imaging over two years.

Design: Eighty-five patients (81.2% women, mean age 59. Read More

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http://dx.doi.org/10.1016/j.joca.2019.03.007DOI Listing
April 2019
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Cartilage wear patterns in severe osteoarthritis of the trapeziometacarpal joint: a quantitative analysis.

Osteoarthritis Cartilage 2019 Apr 5. Epub 2019 Apr 5.

Department of Orthopaedic Surgery, Osaka University, Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan. Electronic address:

Objective: The present quantitative study aimed to assess the three-dimensional (3-D) cartilage wear patterns of the first metacarpal and trapezium in the advanced stage of osteoarthritis (OA) and compare cartilage measurements with radiographic severity.

Design: Using 19 cadaveric trapeziometacarpal (TMC) joints, 3-D cartilage surface models of the first metacarpal and trapezium were created with a laser scanner, and 3-D bone surface model counterparts were similarly created after dissolving the cartilage. These two models were superimposed, and the interval distance on the articular surface as the cartilage thickness was measured. Read More

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http://dx.doi.org/10.1016/j.joca.2019.03.006DOI Listing

Response to: Losina E. Why past research successes do not translate to clinical reality: gaps in evidence on exercise program efficiency. osteoarthritis and cartilage 2019;27:1-2.

Osteoarthritis Cartilage 2019 Mar 29. Epub 2019 Mar 29.

Impact Accelerator Unit, Versus Arthritis Primary Care Centre, Keele University, Staffordshire, ST5 5BG, United Kingdom.

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http://dx.doi.org/10.1016/j.joca.2019.02.801DOI Listing

Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation.

Osteoarthritis Cartilage 2019 Mar 25. Epub 2019 Mar 25.

Institute of Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, UK. Electronic address:

Objective: Physiological mechanical loading reduces inflammatory signalling in numerous cell types including articular chondrocytes however the mechanism responsible remains unclear. This study investigates the role of chondrocyte primary cilia and associated intraflagellar transport (IFT) in the mechanical regulation of interleukin-1β (IL-1β) signalling.

Design: Isolated chondrocytes and cartilage explants were subjected to cyclic mechanical loading in the presence and absence of the cytokine IL-1β. Read More

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http://dx.doi.org/10.1016/j.joca.2019.03.003DOI Listing
March 2019
1 Read

Health resource use and costs of symptomatic knee and/or hip osteoarthritis.

Osteoarthritis Cartilage 2019 Mar 25. Epub 2019 Mar 25.

Sorbonne Université, Institut Pierre Louis de d'Epidémiologie et Santé Publique, GRC08 Paris, France; AP-HP, Pitié-Salpêtrière Hospital, Rheumatology Department, 83 Boulevard de l'Hôpital, 75013 Paris, France. Electronic address:

Background: Data on the economic consequences of hip and knee osteoarthritis (OA) are scarce. We aimed to estimate the annual direct and indirect costs for patients followed for hip and/or knee OA in the Knee and Hip Osteoarthritis Long term Assessment (KHOALA) cohort.

Methods: The KHOALA cohort, set up from 2007 to 2009, is a French multicenter study of 878 individuals with symptomatic knee/hip OA who were 40-75 years old. Read More

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http://dx.doi.org/10.1016/j.joca.2019.03.005DOI Listing
March 2019
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Intraobserver and interobserver reliability of the computed tomography-based radiographic classification of primary elbow osteoarthritis: comparison with plain radiograph-based classification and clinical assessment.

Osteoarthritis Cartilage 2019 Mar 25. Epub 2019 Mar 25.

Department of Orthopedic Surgery, Asan Medical Center, College of Medicine, Ulsan University, Seoul, South Korea. Electronic address:

Objectives: To develop a staging system that could better reflect symptoms by the spurs quantification in the fossa and joint space narrowing using computed tomography (CT) for elbow arthritis and to evaluate its reproducibility with multiple readers.

Methods: This retrospective study evaluated 81 cases of primary elbow osteoarthritis using both plain radiography and CT. Qualitative and quantitative analyses were independently performed by four orthopedic surgeons using previous and newly proposed staging systems. Read More

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http://dx.doi.org/10.1016/j.joca.2019.03.004DOI Listing
March 2019
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Diagnosing osteoarthritis from T maps using deep learning: an analysis of the entire Osteoarthritis Initiative baseline cohort.

Osteoarthritis Cartilage 2019 Mar 21. Epub 2019 Mar 21.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA; Center of Digital Health Innovation (CDHI), USA. Electronic address:

Objective: We aim to study to what extent conventional and deep-learning-based T relaxometry patterns are able to distinguish between knees with and without radiographic osteoarthritis (OA).

Methods: T relaxation time maps were analyzed for 4,384 subjects from the baseline Osteoarthritis Initiative (OAI) Dataset. Voxel Based Relaxometry (VBR) was used for automatic quantification and voxel-based analysis of the differences in T between subjects with and without radiographic OA. Read More

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http://dx.doi.org/10.1016/j.joca.2019.02.800DOI Listing
March 2019
3 Reads

Reproductive factors and risk of total knee replacement due to severe knee osteoarthritis in women, the Singapore Chinese Health Study.

Osteoarthritis Cartilage 2019 Mar 19. Epub 2019 Mar 19.

Health Services and Systems Research, Duke-NUS Medical School, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. Electronic address:

Objectives: Knee osteoarthritis (OA) is more common in women, and may be related to reproductive or hormonal factors. We evaluated these factors with the risk of total knee replacement (TKR) for severe knee OA among women.

Methods: The Singapore Chinese Health Study recruited 63,257 Chinese aged 45-74 years from 1993 to 1998, and among them, 35,298 were women. Read More

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http://dx.doi.org/10.1016/j.joca.2019.03.002DOI Listing
March 2019
3 Reads

Corticosteroids and osteoarthritis progression: a confounded issue.

Authors:
P G Conaghan

Osteoarthritis Cartilage 2019 Mar 18. Epub 2019 Mar 18.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds, UK.

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http://dx.doi.org/10.1016/j.joca.2019.02.799DOI Listing
March 2019
1 Read

A comparison of muscle activation and knee mechanics during gait between patients with non-traumatic and post-traumatic knee osteoarthritis.

Osteoarthritis Cartilage 2019 Mar 18. Epub 2019 Mar 18.

Division of Orthopaedic Surgery, Jewish General Hospital and McGill University, Canada. Electronic address:

Objective: The objective was to compare muscle activation and knee mechanics during gait between participants with non-traumatic knee osteoarthritis (OA), post-traumatic knee OA, and healthy adults.

Design: Participants with non-traumatic knee OA (n = 22), post-traumatic knee OA (n = 19), and healthy adults (n = 22) completed gait trials for this observational, cross-sectional study. Post-traumatic OA group had a history of traumatic anterior cruciate ligament (ACL) rupture. Read More

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http://dx.doi.org/10.1016/j.joca.2019.02.798DOI Listing
March 2019
2 Reads

The ageing joint-standard age- and sex-related values of bone erosions and osteophytes in the hand joints of healthy individuals.

Osteoarthritis Cartilage 2019 Mar 16. Epub 2019 Mar 16.

Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nuremberg (FAU) and Universitaetsklinikum Erlangen, Erlangen, Germany. Electronic address:

Objective: To analyze the age-related changes of the physiological hand joint architecture.

Method: To address this concept, healthy individuals (each 10 women and 10 men in six different age decades spanning from 21 to 80 years) were recruited through a field campaign, investigated for the absence of rheumatic diseases and other comorbidities and received high-resolution quantitative computed tomography (HR-pQCT) examination of the hand joints. Number and extent of erosions and osteophytes were quantified across the ages and different sexes. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.019DOI Listing
March 2019
4 Reads

Joint unloading inhibits articular cartilage degeneration in knee joints of a monosodium iodoacetate-induced rat model of osteoarthritis.

Osteoarthritis Cartilage 2019 Mar 16. Epub 2019 Mar 16.

School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan. Electronic address:

Objective: The aim of the study was to examine how mechanical unloading affects articular cartilage degeneration in the patellofemoral (PF) and tibiofemoral (TF) joints of a monosodium iodoacetate (MIA)-induced rat model of osteoarthritis (OA).

Design: The study involved 60 male rats. OA was induced by intra-articular injecting MIA into both knee joints. Read More

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http://dx.doi.org/10.1016/j.joca.2019.03.001DOI Listing
March 2019
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Maintenance of SOX9 stability and ECM homeostasis by selenium-sensitive PRMT5 in cartilage.

Osteoarthritis Cartilage 2019 Mar 9. Epub 2019 Mar 9.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, PR China; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, Shaanxi, PR China. Electronic address:

Objectives: Selenium (Se) plays pivotal roles in maintaining optimal health. Nevertheless, how Se influences the metabolism of extracellular matrix (ECM) in cartilage remains unclear. The aim of the present study was to observe protein dimethylation by certain Se-sensitive PRMT and to elucidate its effects on the key transcriptional factor in cartilage. Read More

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http://dx.doi.org/10.1016/j.joca.2019.02.797DOI Listing
March 2019
1 Read

Weight loss regimen in obese and overweight individuals is associated with reduced cartilage degeneration: 96-month data from the Osteoarthritis Initiative.

Osteoarthritis Cartilage 2019 Feb 28. Epub 2019 Feb 28.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA. Electronic address:

Purpose: To investigate change in knee cartilage composition over 96 months in overweight and obese participants with constant weight compared to those with weight loss (WL), and to assess how different WL regimens are associated with these changes.

Methods: We studied right knees of 760 participants (age 62.6 ± 9. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584193085
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http://dx.doi.org/10.1016/j.joca.2019.01.018DOI Listing
February 2019
7 Reads

The relationship of weight loss to structure modification in knee OA.

Osteoarthritis Cartilage 2019 Feb 27. Epub 2019 Feb 27.

Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.joca.2019.02.794DOI Listing
February 2019
2 Reads

Bone texture analysis for prediction of incident radiographic hip osteoarthritis using machine learning: data from the Cohort Hip and Cohort Knee (CHECK) study.

Osteoarthritis Cartilage 2019 Feb 28. Epub 2019 Feb 28.

Department of Orthopedics, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Biomechanical Engineering, Delft University of Technology, Delft, the Netherlands. Electronic address:

Objective: To assess the ability of radiography-based bone texture variables in proximal femur and acetabulum to predict incident radiographic hip osteoarthritis (rHOA) over a 10 years period.

Design: Pelvic radiographs from CHECK at baseline (987 hips) were analyzed for bone texture using fractal signature analysis (FSA) in proximal femur and acetabulum. Elastic net (machine learning) was used to predict the incidence of rHOA (including Kellgren-Lawrence grade (KL) ≥ 2 or total hip replacement (THR)), joint space narrowing score (JSN, range 0-3), and osteophyte score (OST, range 0-3) after 10 years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584193086
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http://dx.doi.org/10.1016/j.joca.2019.02.796DOI Listing
February 2019
3 Reads

Hip muscle strength and protection against structural worsening and poor function and disability outcomes in knee osteoarthritis.

Osteoarthritis Cartilage 2019 Feb 28. Epub 2019 Feb 28.

Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address:

Objective: Examine associations of hip abductor strength with (1) cartilage damage worsening in the tibiofemoral and patellofemoral compartments 2 years later, and (2) poor function and disability outcomes 5 years later.

Methods: Participants had knee osteoarthritis (K/L ≥ 2) in at least one knee. Hip abductor strength was measured using Biodex Dynamometry. Read More

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http://dx.doi.org/10.1016/j.joca.2019.02.795DOI Listing
February 2019

Osteoarthritis year in review 2018: genetics and epigenetics.

Authors:
M A Jeffries

Osteoarthritis Cartilage 2019 Mar 25;27(3):371-377. Epub 2018 Oct 25.

University of Oklahoma Health Sciences Center, Department of Internal Medicine, Division of Rheumatology, Immunology, and Allergy, Oklahoma City, OK, USA; Oklahoma Medical Research Foundation, Arthritis & Clinical Immunology Program, Oklahoma City, OK, USA. Electronic address:

Objective: This review was designed to identify highlights of the osteoarthritis (OA) genetics and epigenetics literature published between April 2017 and January 2018.

Design: A Pubmed literature search was conducted using the keywords 'osteoarthritis' and each of the following: 'genomic', 'genetic', 'epigenomic', 'epigenetic', 'histone', 'noncoding RNA', 'miRNA', 'lncRNA', 'DNA methylation', 'DNA hydroxymethylation', 'DNMT', and 'TET'. The dates of publication were restricted to 4/1/2017-1/15/2018. Read More

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http://dx.doi.org/10.1016/j.joca.2018.10.004DOI Listing
March 2019
1 Read

Osteoarthritis year in review 2018: biology.

Authors:
J Sherwood

Osteoarthritis Cartilage 2019 Mar 25;27(3):365-370. Epub 2018 Oct 25.

Institute of Musculoskeletal Medicine, University Hospital Münster, Münster, Germany. Electronic address:

This Year in Review highlights a selection of articles published between the 2017 and 2018 Osteoarthritis Research Society International (OARSI) World Congress meetings within the field of osteoarthritis biology, presented at OARSI 2018. Selected articles were obtained from a PubMed search covering cartilage, subchondral bone, inflammation, ageing, pain and animal models. Studies focused on biomechanics, biomarkers, genetics and epigenetics, imaging and clinical studies were excluded due to their coverage in other articles within the OARSI Year in Review series. Read More

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http://dx.doi.org/10.1016/j.joca.2018.10.005DOI Listing
March 2019
1 Read

3D bone-shape changes and their correlations with cartilage T1ρ and T2 relaxation times and patient-reported outcomes over 3-years after ACL reconstruction.

Osteoarthritis Cartilage 2019 Feb 23. Epub 2019 Feb 23.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA; Program of Advanced Musculoskeletal Imaging (PAMI), Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Purpose: (1) To identify bone-shape changes from baseline to 3-years after anterior cruciate ligament reconstruction (ACLR). (2) to assess association between changes in bone-shape from baseline to 6-months and changes in cartilage matrix and patient functions and symptoms from baseline to 3-years after ACLR.

Methods: Bilateral knees of 30 patients with unilateral ACL injuries were scanned at baseline, 6-months, 1-, 2-, and 3-years after ACLR. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.017DOI Listing
February 2019
6 Reads

Spatial distribution and temporal progression of T2 relaxation time values in knee cartilage prior to the onset of cartilage lesions - data from the Osteoarthritis Initiative (OAI).

Osteoarthritis Cartilage 2019 Feb 23. Epub 2019 Feb 23.

Musculoskeletal and Quantitative Imaging Group (MQIR), Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.

Purpose: To investigate compositional changes of knee cartilage at the site of newly appearing cartilage lesions and the surrounding cartilage 1-4 years prior to lesion onset using quantitative T2-measurements.

Methods: Fifty-seven cartilage plates with newly appearing cartilage lesions from 45 knees (cases) and 52 plates from 26 control knees from the Osteoarthritis Initiative (OAI) cohort (controls) were evaluated. Using MRI T2-mapping, composition of local (the site of future lesions) and surrounding cartilage (remainder of the cartilage plate) was assessed 1-4 years prior to lesion onset. Read More

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http://dx.doi.org/10.1016/j.joca.2018.10.016DOI Listing
February 2019

Cause-specific mortality in osteoarthritis of peripheral joints.

Osteoarthritis Cartilage 2019 Feb 21. Epub 2019 Feb 21.

Clinical Epidemiology Unit, Orthopedics, Department of Clinical Sciences, Lund, Lund University, Lund, Sweden. Electronic address:

Purpose: To estimate cause-specific mortality in osteoarthritis patients compared to the general population.

Methods: We identified all residents in southern Sweden aged 45-84 years in 2003. Through the Skåne Healthcare Register (SHR) we identified those diagnosed with osteoarthritis in peripheral joints between 1998 and 2003. Read More

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http://dx.doi.org/10.1016/j.joca.2019.02.793DOI Listing
February 2019
2 Reads

Distinct degenerative phenotype of articular cartilage from knees with meniscus tear compared to knees with osteoarthritis.

Osteoarthritis Cartilage 2019 Feb 21. Epub 2019 Feb 21.

Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

Objective: To compare the transcriptome of articular cartilage from knees with meniscus tears to knees with end-stage osteoarthritis (OA).

Design: Articular cartilage was collected from the non-weight bearing medial intercondylar notch of knees undergoing arthroscopic partial meniscectomy (APM; N = 10, 49.7 ± 10. Read More

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http://dx.doi.org/10.1016/j.joca.2019.02.792DOI Listing
February 2019
1 Read

Patient characteristics affect hip contact forces during gait.

Osteoarthritis Cartilage 2019 Feb 15. Epub 2019 Feb 15.

Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; NIHR Leeds Biomedical Research Centre, Leeds, UK. Electronic address:

Objective: To examine hip contact force (HCF), calculated through multibody modelling, in a large total hip replacement (THR) cohort stratified by patient characteristics such as body mass index (BMI), age and function.

Method: 132 THR patients undertook one motion capture session of gait analysis at a self-selected walking speed. HCFs were then calculated using the AnyBody Modelling System. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.016DOI Listing
February 2019
1 Read

Diagnosis of calcium pyrophosphate deposition by imaging - current state and challenges remaining.

Authors:
F Becce

Osteoarthritis Cartilage 2019 Apr 8;27(4):545-546. Epub 2019 Feb 8.

Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.joca.2019.01.015DOI Listing
April 2019
1 Read

Diagnostic value of ultrasound in calcium pyrophosphate deposition disease of the knee joint.

Osteoarthritis Cartilage 2019 Feb 6. Epub 2019 Feb 6.

Division of Rheumatology, Department of Internal Medicine, Research Institute of Medical Science, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, South Korea. Electronic address:

Objective: To assess the diagnostic performance of ultrasound (US) for calcium pyrophosphate deposition (CPPD) at the level of menisci, hyaline cartilage (HC), tendons, and synovial fluid (SF) of the knee, and to examine inter- and intra-observer reliability.

Design: We consecutively included patients with knee effusion over a 2-year period (43 patients with CPPD and 131 controls). All patients underwent SF analysis, conventional radiography (CR), and US examination using the Outcome Measures in Rheumatology (OMERACT) definition of the US characteristics of CPPD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584193004
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http://dx.doi.org/10.1016/j.joca.2018.11.013DOI Listing
February 2019
4 Reads

Compositional changes predict morphologic cartilage lesion development - are we one step closer to clinical translation of quantitative MRI?

Authors:
X Li F W Roemer

Osteoarthritis Cartilage 2019 Feb 6. Epub 2019 Feb 6.

Department of Radiology, University of Erlangen-Nuremberg; Erlangen, Germany; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.joca.2019.01.014DOI Listing
February 2019
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Nutrient supply and nucleus pulposus cell function: effects of the transport properties of the cartilage endplate and potential implications for intradiscal biologic therapy.

Osteoarthritis Cartilage 2019 Feb 2. Epub 2019 Feb 2.

Department of Orthopaedic Surgery, University of California San Francisco, USA. Electronic address:

Objective: Intradiscal biologic therapy is a promising strategy for managing intervertebral disc degeneration. However, these therapies require a rich nutrient supply, which may be limited by the transport properties of the cartilage endplate (CEP). This study investigated how fluctuations in CEP transport properties impact nutrient diffusion and disc cell survival and function. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.013DOI Listing
February 2019
1 Read

Social & psychological factors associated with oral analgesic use in knee osteoarthritis management.

Osteoarthritis Cartilage 2019 Feb 1. Epub 2019 Feb 1.

College of Medicine and UA Arthritis Center, University of Arizona (UA), Tucson, AZ, USA.

Objective: Determine modifiable social and psychological health factors that are associated with use of oral opioid and non-opioid medications for OA.

Methods: Patients were categorized based on use of the following oral medications: opioids (with/without other oral analgesic treatments), non-opioid analgesics, and no oral analgesic treatment. We used multinomial logistic regression models to estimate adjusted relative risk ratios (RRRs) of using an opioid or a non-opioid analgesic (vs. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.010DOI Listing
February 2019
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A 12-item short form of the Knee injury and Osteoarthritis Outcome Score (KOOS-12): tests of reliability, validity and responsiveness.

Osteoarthritis Cartilage 2019 Feb 1. Epub 2019 Feb 1.

University of Massachusetts Medical School, Worcester, MA, USA; John Ware Research Group, Watertown, MA, USA. Electronic address:

Objective: To evaluate reliability, validity and responsiveness of KOOS-12, a 12-item short form of the 42-item Knee injury and Osteoarthritis Outcome Score (KOOS) that provides Pain, Function and Quality of Life (QOL) scale scores and a summary knee impact score.

Design: Data from 1,392 knee osteoarthritis (OA) patients from the FORCE-TJR research cohort who completed KOOS before and 6 and 12 months after total knee replacement (TKR) were analyzed. KOOS-12 includes a pain frequency item and three items measuring pain during increasingly difficult (sitting/lying, walking, stairs) activities; function items about standing, rising from sitting, getting in/out of a car, and twisting/pivoting; and the 4-item KOOS QOL scale. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.011DOI Listing
February 2019
1 Read

Clock mutant promotes osteoarthritis by inhibiting the acetylation of NFκB.

Osteoarthritis Cartilage 2019 Feb 2. Epub 2019 Feb 2.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; Research Center on Aging and Medicine, Fudan University, Shanghai 200032, China. Electronic address:

Objectives: To examine the effect of the circadian gene Clock on posttranscriptional function and pro-inflammatory mechanisms in osteoarthritis (OA).

Methods: The cartilage from Clock mutant mice was assessed using histology, (OA) score, and real-time polymerase chain reaction (PCR) quantification of key pro-inflammatory genes. Nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) translocation, posttranslational state and expression levels during day and night conditions were assessed using immunoblot and IP. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.012DOI Listing
February 2019
1 Read

Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction.

Osteoarthritis Cartilage 2019 Feb 1. Epub 2019 Feb 1.

Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. Electronic address:

Objective: The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that integrates nutrients to execute cell growth. We hypothesized that mTOR is influential in the intervertebral disc-largest avascular, low-nutrient organ. Our objective was to identify the optimal mTOR inhibitor for treating human degenerative disc disease. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.009DOI Listing
February 2019
3 Reads

Changes in stiffness and biochemical composition of the pericellular matrix as a function of spatial chondrocyte organisation in osteoarthritic cartilage.

Osteoarthritis Cartilage 2019 Jan 31. Epub 2019 Jan 31.

Laboratory of Cell Biology, Department of Orthopaedic Surgery, University Hospital of Tübingen, Waldhörnlestraße 22, D-72072 Tübingen, Germany; Department of Orthopaedic Surgery, University Hospital of Tübingen, Hoppe-Seyler-Strasse 3, D-72076 Tübingen, Germany. Electronic address:

Objective: During osteoarthritis (OA), chondrocytes seem to change their spatial arrangement from single to double strings, small and big clusters. Since the pericellular matrix (PCM) appears to degrade alongside this reorganisation, it has been suggested that spatial patterns act as an image-based biomarker for OA. The aim of this study was to establish the functional relevance of spatial organisation in articular cartilage. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.008DOI Listing
January 2019
1 Read

Intra-articular corticosteroids and the risk of knee osteoarthritis progression: results from the Osteoarthritis Initiative.

Osteoarthritis Cartilage 2019 Jan 29. Epub 2019 Jan 29.

Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Objective: A recent randomized clinical trial reported that repeated intra-articular corticosteroids (IACs) were associated with a greater cartilage loss. This study aimed to examine the relation of IACs to knee radiographic osteoarthritis (ROA) progression in a real-world setting.

Design: A cohort that initiated IACs and a comparison cohort without IACs from participants with mild to moderate knee ROA in the Osteoarthritis Initiative (OAI) were assembled (from 0-month to 48-month). Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.007DOI Listing
January 2019
4 Reads

Fibronectin fragment inhibits xylosyltransferase-1 expression by regulating Sp1/Sp3- dependent transcription in articular chondrocytes.

Osteoarthritis Cartilage 2019 Jan 24. Epub 2019 Jan 24.

Division of Rheumatology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi, 431-070, South Korea; Institute for Skeletal Aging, Hallym University, Chunchon 200-702, South Korea. Electronic address:

Objective: We investigated the effects of 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) on xylosyltransferase-1 (XT-1), an essential anabolic enzyme that catalyzes the initial and rate-determining step in glycosaminoglycan chain synthesis, in human primary chondrocytes.

Methods: Proteoglycan and XT-1 expression in cartilage tissue was analyzed using safranin O staining and immunohistochemistry. The effects of 29-kDa FN-f on XT-1 expression and its relevant signaling pathway were analyzed by quantitative real-time-PCR, immunoblotting, chromatin immunoprecipitation, and immunoprecipitation assays. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.006DOI Listing
January 2019
2 Reads

Opioid use in knee or hip osteoarthritis: a region-wide population-based cohort study.

Osteoarthritis Cartilage 2019 Jan 22. Epub 2019 Jan 22.

Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Lund, Sweden; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA.

Objective: To quantify opioid use in knee and hip osteoarthritis (OA) patients, and to estimate the proportion of opioids in the population attributable to OA patients.

Design: Population-based cohort study.

Methods: We included 751,579 residents in southern Sweden, aged ≥35 years in 2015. Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.005DOI Listing
January 2019
1 Read

Health professionals and students encounter multi-level barriers to implementing high-value osteoarthritis care: a multi-national study.

Osteoarthritis Cartilage 2019 Jan 19. Epub 2019 Jan 19.

School of Physiotherapy and Exercise Science, Curtin University, Australia. Electronic address:

Objective: Consistent evidence-practice gaps in osteoarthritis (OA) care are observed in primary care settings globally. Building workforce capacity to deliver high-value care requires a contemporary understanding of barriers to care delivery. We aimed to explore barriers to OA care delivery among clinicians and students. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.024DOI Listing
January 2019
3 Reads

Midfoot osteoarthritis: potential phenotypes and their associations with demographic, symptomatic and clinical characteristics.

Osteoarthritis Cartilage 2019 Apr 17;27(4):659-666. Epub 2019 Jan 17.

Arthritis Research UK Primary Care Centre, Research Institute for Primary Care and Health Sciences, Keele University, Staffordshire, UK; Haywood Academic Rheumatology Centre, Midlands Partnership NHS Foundation Trust, Haywood Hospital, Staffordshire, UK.

Objective: To investigate the demographic, symptomatic, clinical and structural foot characteristics associated with potential phenotypes of midfoot osteoarthritis (OA).

Design: Cross-sectional study of 533 community-dwelling adults aged ≥50 years with foot pain in the past year. Health questionnaires and clinical assessments of symptoms, foot structure and function were undertaken. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.022DOI Listing
April 2019
5 Reads

Sagittal plane walking biomechanics in individuals with knee osteoarthritis after quadriceps strengthening.

Osteoarthritis Cartilage 2019 Jan 18. Epub 2019 Jan 18.

University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

Objective: To compare sagittal walking gait biomechanics between participants with knee osteoarthritis (KOA) who increased quadriceps strength following a lower-extremity strengthening intervention (responders) and those who did not increase strength following the same strengthening protocol (non-responders) both at baseline and following the lower extremity strengthening protocol.

Design: Fifty-three participants with radiographic KOA (47% female, 62.3 ± 7. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.026DOI Listing
January 2019
2 Reads

Model-based pain and function outcome trajectory types for patients undergoing knee arthroplasty: a secondary analysis from a randomized clinical trial.

Osteoarthritis Cartilage 2019 Jan 17. Epub 2019 Jan 17.

Departments of Physical Therapy, Orthopaedic Surgery and Rheumatology, Virginia Commonwealth University, Richmond, VA, USA.

Objective: Knee arthroplasty (KA) is an effective surgical procedure. However, clinical studies suggest that a considerable number of patients continue to experience substantial pain and functional loss following surgical recovery. We aimed to estimate pain and function outcome trajectory types for persons undergoing KA, and to determine the relationship between pain and function trajectory types, and pre-surgery predictors of trajectory types. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584193002
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http://dx.doi.org/10.1016/j.joca.2019.01.004DOI Listing
January 2019
8 Reads

The evolving large-strain shear responses of progressively osteoarthritic human cartilage.

Osteoarthritis Cartilage 2019 Jan 18. Epub 2019 Jan 18.

University of Connecticut, Department of Mechanical Engineering, Storrs, CT, USA; University of Connecticut, Department of Biomedical Engineering, Storrs, CT, USA. Electronic address:

Objective: The composition and structure of articular cartilage evolves during the development and progression of osteoarthritis (OA) resulting in changing mechanical responses. We aimed to assess the evolution of the intrinsic, large-strain mechanics of human articular cartilage-governed by collagen and proteoglycan and their interactions-during the progression of OA.

Design: We completed quasi-static, large-strain shear tests on 64 specimens from ten donors undergoing total knee arthroplasty (TKA), and quantified the corresponding state of OA (OARSI grade), structural integrity (PLM score), and composition (glycosaminoglycan and collagen content). Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.025DOI Listing
January 2019
6 Reads

Marked and rapid change of bone shape in acutely ACL injured knees - an exploratory analysis of the Kanon trial.

Osteoarthritis Cartilage 2019 Apr 14;27(4):638-645. Epub 2019 Jan 14.

Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopedics, Lund, Sweden.

Background: To investigate changes in knee 3D bone shape over the first 5 years after acute anterior cruciate ligament (ACL) injury in participants of the randomized controlled KANON-trial.

Methods: Serial MR images over 5 years from 121 young (32 women, mean age 26.1 years) adults with an acute ACL tear in a previously un-injured knee were analyzed using statistical shape models for bone. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584193001
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http://dx.doi.org/10.1016/j.joca.2018.12.021DOI Listing
April 2019
8 Reads

Relationship between alignment and cartilage thickness in patients with non-traumatic and post-traumatic knee osteoarthritis.

Osteoarthritis Cartilage 2019 Apr 14;27(4):630-637. Epub 2019 Jan 14.

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Canada. Electronic address:

Objective: To compare cartilage thickness between patients with non-traumatic and post-traumatic knee osteoarthritis (OA) and healthy controls and to determine if disease severity and alignment impact these differences.

Design: Participants with non-traumatic (n = 22) and post-traumatic (n = 19) knee OA, and healthy controls (n = 22) were recruited for this cross-sectional study. Participants underwent 3T magnetic resonance imaging (T1-weighted, 3D sagittal gradient echo sequence) and cartilage thickness was determined in four regions: medial and lateral condyle, and medial and lateral plateau. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584193001
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http://dx.doi.org/10.1016/j.joca.2019.01.002DOI Listing
April 2019
7 Reads

Potential diagnostic value of a type X collagen neo-epitope biomarker for knee osteoarthritis.

Osteoarthritis Cartilage 2019 Apr 14;27(4):611-620. Epub 2019 Jan 14.

Rheumatology, Biomarkers and Research, Nordic Bioscience, Herlev, Denmark. Electronic address:

Objective: Phenotypic changes of chondrocytes toward hypertrophy might be fundamental in the pathogenesis of osteoarthritis (OA), of which type X collagen (Col10) is a well-known marker. The purpose was to develop a specific immunoassay for blood quantification of a newly identified neo-epitope of type Col10 to assess its diagnostic value for radiographic knee OA.

Methods: A neo-epitope of Col10 was identified in urine samples from OA patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584193001
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http://dx.doi.org/10.1016/j.joca.2019.01.001DOI Listing
April 2019
16 Reads

Ambulatory activity interacts with common risk factors for osteoarthritis to modify increases in MRI-detected osteophytes.

Osteoarthritis Cartilage 2019 Apr 14;27(4):650-658. Epub 2019 Jan 14.

Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; Department of Rheumatology and Immunology, Arthritis Research Institute, The First Affiliate Hospital of Anhui Medical University, Hefei, China. Electronic address:

Objective: To investigate the longitudinal association between objectively measured ambulatory activity (AA) and knee MRI-detected osteophytes (OPs), and to test whether this relationship was modified by common risk factors for OA including sex, obesity, disease severity and knee injury history.

Methods: 408 community-dwelling adults aged 51-81 years were assessed at baseline and 2.7 years. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.023DOI Listing
April 2019
1 Read

The natural initiation and progression of osteoarthritis in the anterior cruciate ligament deficient feline knee.

Osteoarthritis Cartilage 2019 Apr 11;27(4):687-693. Epub 2019 Jan 11.

Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Objective: The aim of this study was to document the natural history of development and long-term progression of osteoarthritis (OA) in the feline knee after minimally invasive anterior cruciate ligament (ACL) transection.

Design: ACL transections of the left knee joint of 14 skeletally mature cats were performed. Radiographic scores, tibiofemoral and patellofemoral joint space and anterior tibial translation were assessed before, immediately and every 3 months after ACL transection (longest follow-up: 93 months). Read More

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http://dx.doi.org/10.1016/j.joca.2019.01.003DOI Listing
April 2019
1 Read

Tibial plateau fractures are associated with a long-lasting increased risk of total knee arthroplasty a matched cohort study of 7,950 tibial plateau fractures.

Osteoarthritis Cartilage 2019 Jan 8. Epub 2019 Jan 8.

Department of Occupational Therapy and Physiotherapy, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark.

Objective: This study aims to investigate the risk of total knee replacement (TKR) following tibia plateau fractures. Secondary the study aims to investigate the risk of knee arthroscopy following tibial plateau fractures.

Method: The study was designed as a matched cohort study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584193000
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http://dx.doi.org/10.1016/j.joca.2018.12.020DOI Listing
January 2019
7 Reads

Nature vs nurture in knee osteoarthritis - the importance of age, sex and body mass index.

Osteoarthritis Cartilage 2019 Apr 8;27(4):586-592. Epub 2019 Jan 8.

Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Clinical Epidemiology Unit, Lund, Sweden; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA. Electronic address:

Objective: (1) To estimate the life-time genetic contribution for knee osteoarthritis (OA) surgery and (2) to explore any differences in the genetic contribution across age, sex and body mass index (BMI).

Methods: We studied the sex-specific genetic contribution to knee OA surgery in a prospective cohort study of 62,490 twins aged 35 years or older with a follow-up period of up to 47 years (10,092 identical and 21,153 non-identical twin pairs, 54% women). To study interactions with age, we graphed the heritabilities over the lifespan for men and women. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.018DOI Listing