80,021 results match your criteria Osteoarthritis Primary


The protective effect of sophocarpine in osteoarthritis: An in vitro and in vivo study.

Int Immunopharmacol 2018 Dec 11;67:145-151. Epub 2018 Dec 11.

Department of Anesthesiology, The Second Affiliated Hospital of Wen Zhou Medical University, 109, Xueyuanxi Road, 325027 Wenzhou, China. Electronic address:

Background: Osteoarthritis (OA) is a type of degenerative joint disease affecting millions of individuals worldwide. However, there are currently no great inflammatory treatments available for it. Sophocarpine (SPC), one of the key bioactive compounds derived from Sophora flavescens, has shown remarkable anti-inflammatory effects. Read More

View Article
December 2018
1 Read

Deficits in rate of torque development are accompanied by activation failure in patients with knee osteoarthritis.

J Electromyogr Kinesiol 2018 Dec 4;44:94-100. Epub 2018 Dec 4.

Human Performance Lab, Schulthess Clinic, Zurich, Switzerland. Electronic address:

Aim of this study was to investigate if knee extensor maximal voluntary contraction (MVC) torque and rate of torque development (RTD) deficits are accompanied by neuromuscular activation failure in patients with knee osteoarthritis (KOA). Nineteen patients with unilateral KOA completed gradual MVCs, from which MVC torque, voluntary activation and maximal EMG activity were recorded, and explosive MVCs, from which RTD and rate of EMG rise were recorded. For gradual MVCs, MVC torque (-28%), voluntary activation (-6%) and maximal EMG activity (-30%) were lower on the involved than on the uninvolved side (p < 0. Read More

View Article
December 2018

LncRNA PMS2L2 protects ATDC5 chondrocytes against lipopolysaccharide-induced inflammatory injury by sponging miR-203.

Life Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedics, Affiliated Hospital of Jining Medical University, Jining 272029, China. Electronic address:

Aims: PMS1 Homolog 2, Mismatch Repair System Component Pseudogene 2 (PMS2L2) has been reported as an up-regulated long non-coding RNA (lncRNA) in osteoarthritis (OA) tissues. The purpose of the present work is to explore whether the differently expressed PMS2L2 is associated with the pathogenesis of OA.

Main Methods: Chondrogenic ATDC5 cells were exposed to various doses of lipopolysaccharide (LPS). Read More

View Article
December 2018

USP14-mediated IκBα degradation exacerbates NF-κB activation and IL-1β-stimulated chondrocyte dedifferentiation.

Life Sci 2018 Dec 11. Epub 2018 Dec 11.

Rehabilitation Department, the Third Hospital of Xingtai City, Xingtai City, Hebei 054000, China.

Osteoarthritis (OA) is an inflammatory joint disease. USP14, a deubiquitinating enzyme critical for ubiquitin-mediated proteasomal protein degradation, is implicated in inflammation regulation. However, its role and mechanism in OA are poorly understood. Read More

View Article
December 2018

Roles for HB-EGF in Mesenchymal Stromal Cell Proliferation and Differentiation During Skeletal Growth.

J Bone Miner Res 2018 Dec 14. Epub 2018 Dec 14.

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.

HB-EGF, a member of the EGF superfamily, plays important roles in development and tissue regeneration. However, its functions in skeletal stem cells and skeleton development and growth remain poorly understood. Here, we used the Cre/LoxP system to ablate or express HB-EGF in Dermo1+ mesenchymal stromal cells and their progenies, including chondrocytes and osteoblast lineage cells, and bone marrow stromal cells (BMSCs). Read More

View Article
December 2018

Use of Opioid Analgesics in Patients with Chronic Low Back Pain and Knee Osteoarthritis.

Am J Phys Med Rehabil 2018 Dec 13. Epub 2018 Dec 13.

Department of Physical Medicine and Rehabilitation, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.

View Article
December 2018

What Is the Prevalence of Cam Deformity After Prophylactic Pinning of the Contralateral Asymptomatic Hip in Unilateral Slipped Capital Femoral Epiphysis? A 10-year Minimum Followup Study.

Clin Orthop Relat Res 2018 Dec 13. Epub 2018 Dec 13.

T. D. Lerch, F. Schmaranzer, S. D. Steppacher, M. Tannast, K. A. Siebenrock, Department of Orthopaedic Surgery, Inselspital, University of Bern, Bern, Switzerland E. N. Novais, Department of Pediatric Orthopedic surgery, Boston Children's Hospital, Boston, MA, USA K. Ziebarth, Department of Pediatric Surgery, Inselspital, University of Bern, Bern, Switzerland.

Background: Prophylactic pinning of the asymptomatic and normal-appearing contralateral hip in patients with unilateral slipped capital femoral epiphysis (SCFE) remains controversial. Understanding the minimal 10-year clinical, functional, and radiographic outcomes of the contralateral asymptomatic hip in unilateral SCFE may be helpful in the decision regarding whether the benefits associated with potentially preventing a SCFE are outweighed by the risk of additional surgery.

Questions/purposes: Among patients with SCFE treated with prophylactic pinning of the asymptomatic and contralateral hip, we sought (1) to determine the complications and reoperations; (2) to evaluate the development of cam deformities and the frequency and severity of osteoarthritis progression; and (3) to characterize hip pain and function as measured by the Harris hip score (HHS) and the Hip Disability and Osteoarthritis Outcome Score (HOOS) at minimal 10-year followup. Read More

View Article
December 2018

[Knee osteotomies : a renaissance ?]

Rev Med Suisse 2018 Dec;14(631):2254-2258

Service d'orthopédie et de traumatologie de l'appareil locomoteur, Chirurgie du genou, Département de l'appareil locomoteur, CHUV, 1011 Lausanne.

There is a regain of interest for knee osteotomies over the last decade. A better knowledge of their long-term benefits and potential adverse events has increased their importance in the treatment of unicompartmental osteoarthritis. Emerging indications result from increasing evidence that the control of knee alignment is crucial in knee instability, meniscal transplantation and cartilage repair. Read More

View Article
December 2018

[Iatrogenic femoral head fracture during a closed reduction of posterior dislocation of hip. Case report].

Acta Ortop Mex 2018 Jul-Aug;32(4):234-239

Servicio de Cadera y Pelvis del Hospital General de Querétaro. Querétaro, México.

The fracture dislocation of the hip is a rare lesion described up to 4 to 17% of the cases and usually secondary to automobile accidents. Generally of poor prognosis and with already well documented complications such as avascular necrosis of the femoral head, osteoarthritis and heterotopic ossification. The iatrogenic fracture of the neck or head of the proximal femur is a complication even more rare and is not documented its incidence in the world literature. Read More

View Article
December 2018

Association of Asian mitochondrial DNA haplogroup B with new development of knee osteoarthritis in Koreans.

Int J Rheum Dis 2018 Dec 13. Epub 2018 Dec 13.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.

Aim: The aim of this study was to determine which mitochondrial DNA (mtDNA) haplogroup is associated with new development of knee osteoarthritis (OA).

Methods: Epidemiologic data and knee radiographs with the Kellgren-Lawrence (K/L) score of the Ansung cohort study were prospectively obtained from the 2nd (2005-2006) and 6th follow-up periods (2013-2014). The mtDNA was analyzed by multiplex mutagenetically separated polymerase chain reaction to determine Asian mtDNA haplogroups (M, G, D, D4, D5, M7, M8, M9, M10, N, A, N9, R, F and B). Read More

View Article
December 2018

Methylene blue regulates inflammatory response in osteoarthritis by noncoding long chain RNA CILinc02.

J Cell Biochem 2018 Dec 12. Epub 2018 Dec 12.

The Second Department of Orthopedics, Zhang Zhou Zhengxing Hospital, Zhangzhou, China.

Long noncoding RNAs serve as novel regulatory molecules involved in various biological processes, but their role in osteoarthritis (OA) remains unknown. Therefore, we aimed to reveal the inflammatory mechanisms regulated by CILinc02 and methylene blue in human osteoarthritic cartilage and to explore the potential functions of CILinc02 and methylene blue in OA. The expression level of CILinc02 in OA cartilage tissues and primary cells was obtained using quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). Read More

View Article
December 2018

Naproxen attenuates osteoarthritis progression through inhibiting the expression of prostaglandinl-endoperoxide synthase 1.

J Cell Physiol 2018 Dec 12. Epub 2018 Dec 12.

2nd Ward of Burn Department, Linyi People's Hospital, Linyi, Shandong, China.

Objective: This study aims to test the effect of naproxen treatment and the biological target of naproxen for treating osteoarthritis (OA).

Methods: Differentially expressed genes (DEGs) in OA synovial tissues and normal counterparts were analyzed by messenger RNA microarray analysis. R package (weighted gene coexpression network analysis) was used to divide DEGs into several modules and determine the hub genes in each module. Read More

View Article
December 2018

Multiple papillary fibroelastomas of the aortic valve detected by real time three-dimensional transesophageal echocardiographic images.

J Cardiol Cases 2013 Jul 30;8(1):e9-e12. Epub 2013 Apr 30.

Department of Medicine and Biological Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.

Papillary fibroelastoma (PFE) is a well-known primary cardiac tumor, but multiple PFEs are rare. We report an interesting case with multiple PFEs that were clearly demonstrated and evaluated with real time three-dimensional (RT3D) transesophageal echocardiography (TEE). A 77-year-old woman was referred to our institution with a diagnosis of osteoarthritis of the hip. Read More

View Article

Utilizing Atlas-Based Modeling to Predict Knee Joint Cartilage Degeneration: Data from the Osteoarthritis Initiative.

Ann Biomed Eng 2018 Dec 13. Epub 2018 Dec 13.

Department of Applied Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland.

Currently, there are no clinically available tools or applications which could predict osteoarthritis development. Some computational models have been presented to simulate cartilage degeneration, but they are not clinically feasible due to time required to build subject-specific knee models. Therefore, the objective of this study was to develop a template-based modeling method for rapid prediction of knee joint cartilage degeneration. Read More

View Article
December 2018
3 Reads

Size of ischial fibro-ostosis is associated with heterotopic ossification after total hip arthroplasty.

Int Orthop 2018 Dec 13. Epub 2018 Dec 13.

Department of Orthopedic and Trauma Surgery, University of Heidelberg, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany.

Purpose: The hypothesis of the present study was that degenerative fibro-ostosis (FO) of the ischial hamstring tendon insertion is a risk factor for heterotopic ossification (HO) following THA.

Methods: We followed 103 consecutive patients (43 males, 60 females, mean age 61 years) who underwent unilateral cementless THA for primary hip osteoarthritis and investigated the incidence of HO within the first 12 months after surgery. On pre-operative radiographs, a standardized evaluation for FO of the ischial hamstring tendon insertion concerning horizontal, vertical, and square dimensions was performed. Read More

View Article
December 2018

Cartilage Tissue Engineering Using Stem Cells and Bioprinting Technology-Barriers to Clinical Translation.

Front Surg 2018 27;5:70. Epub 2018 Nov 27.

Department of Surgery, University of Melbourne, Melbourne, VIC, Australia.

There is no long-term treatment strategy for young and active patients with cartilage defects. Early and effective joint preserving treatments in these patients are crucial in preventing the development of osteoarthritis. Tissue engineering over the past few decades has presented hope in overcoming the issues involved with current treatment strategies. Read More

View Article
November 2018

The osteoarthritis-associated gene PAPSS2 promotes differentiation and matrix formation in ATDC5 chondrogenic cells.

Exp Ther Med 2018 Dec 11;16(6):5190-5200. Epub 2018 Oct 11.

Department of Orthopedic Surgery, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.

3'-Phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2) has been shown to be important in the development of normal skeletal structure. The aim of the present study was to evaluate the role of PAPSS2 in the differentiation of chondrocytes as well as their mechanisms. Using RNA interference-mediated via a lentivirus and a retrovirus, PAPSS2 gene silence and overexpression in ATDC5 chondrogenic cells were performed. Read More

View Article
December 2018

Imbalance of M1/M2 macrophages is linked to severity level of knee osteoarthritis.

Exp Ther Med 2018 Dec 11;16(6):5009-5014. Epub 2018 Oct 11.

Department of Emergency Surgery, The Affiliated Qingdao Hiser Hospital of Qingdao University (Qingdao Hospital of Traditional Chinese Medicine), Qingdao, Shandong 266001, P.R. China.

Macrophages, whether M1 or M2 subtype, have been found to be implicated in the pathogenesis of osteoarthritis (OA). However, no study regarding the status of M1 and M2 macrophages has been reported in knee OA. To investigate the status of M1 and M2 macrophages in knee OA, synovial fluid as well as peripheral blood were collected from 80 patients with knee OA and 80 healthy controls. Read More

View Article
December 2018
1 Read

Local infiltration analgesia versus interscalene nerve block for postoperative pain control after shoulder arthroplasty: a prospective, randomized, comparative noninferiority study involving 99 patients.

J Shoulder Elbow Surg 2018 Dec 10. Epub 2018 Dec 10.

Hôpitaux Universitaires Paris Ile-de-France Ouest, Assistance Publique-Hôpitaux de Paris (AP-HP), Boulogne-Billancourt, France; Université de Versailles Saint-Quentin-en-Yvelines, Versailles, France.

Background: The aim of this study was to compare the efficacy of local infiltration analgesia (LIA) and interscalene nerve block (ISB) for early postoperative pain control after total shoulder arthroplasty (TSA). The hypothesis was that LIA is not inferior to ISB.

Methods: A prospective, randomized controlled study was performed in 2014-2016. Read More

View Article
December 2018

A specific protocol of autologous bone marrow concentrate and platelet products versus exercise therapy for symptomatic knee osteoarthritis: a randomized controlled trial with 2 year follow-up.

J Transl Med 2018 Dec 13;16(1):355. Epub 2018 Dec 13.

CAPHRI, School of Public Health and Primary Care, Maastricht University, Maastricht, Netherlands.

Background: Cell-based therapies have shown promise for the treatment of knee osteoarthritis (OA). The current study compared exercise therapy to autologous bone marrow concentrate (BMC) and platelet products for knee OA treatment.

Methods: Patients with symptomatic knee OA (N = 48) were randomized into either an exercise therapy control group or treatment group with injection of autologous BMC and platelet products. Read More

View Article
December 2018

Platelet-Rich Plasma Versus Hyaluronic Acid Injections for the Treatment of Knee Osteoarthritis: Results at 5 Years of a Double-Blind, Randomized Controlled Trial.

Am J Sports Med 2018 Dec 13:363546518814532. Epub 2018 Dec 13.

Applied and Translational Research Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Background:: Platelet-rich plasma (PRP) injections have been proposed as a new conservative option for knee degeneration to provide symptomatic relief and delay surgical intervention. Although the current literature provides some evidence on the benefits of this technique compared with viscosupplementation, no studies have been performed to compare their long-term effects.

Purpose:: To compare the long-term clinical outcomes provided by intra-articular injections of either PRP or hyaluronic acid (HA) to treat knee degenerative disease. Read More

View Article
December 2018

Spectrum-Effect Relationships between High-Performance Liquid Chromatography (HPLC) Fingerprints and the Antioxidant and Anti-Inflammatory Activities of Collagen Peptides.

Molecules 2018 Dec 10;23(12). Epub 2018 Dec 10.

College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.

A total of 13 batches of collagen peptide samples were extracted, isolated, and purified from chicken sternal cartilage under various process parameters. The fingerprint profiles of 13 batches of collagen peptides were established by high-performance liquid chromatography (HPLC). In addition, the amino acid profiles and molecular weight distributions of collagen peptides were investigated. Read More

View Article
December 2018
1 Read

Systematic Analysis of Transcriptomic Profile of Chondrocytes in Osteoarthritic Knee Using Next-Generation Sequencing and Bioinformatics.

J Clin Med 2018 Dec 10;7(12). Epub 2018 Dec 10.

Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

The phenotypic change of chondrocytes and the interplay between cartilage and subchondral bone in osteoarthritis (OA) has received much attention. Structural changes with nerve ingrowth and vascular penetration within OA cartilage may contribute to arthritic joint pain. The aim of this study was to identify differentially expressed genes and potential miRNA regulations in OA knee chondrocytes through next-generation sequencing and bioinformatics analysis. Read More

View Article
December 2018

Amniotic Tissue Modulation of Knee Pain-A Focus on Osteoarthritis.

J Knee Surg 2018 Dec 13. Epub 2018 Dec 13.

Cartilage Restoration Center, OrthoIndy Hospital, Greenwood, Indiana.

The use of intra-articular therapies as sources of growth factors, anti-inflammatory mediators, and medicinal signaling cells for osteoarthritis (OA) is rapidly evolving. Amnion, chorion, amniotic fluid, and the umbilical cord are distinct placental tissues that have been investigated for use in OA. Amniotic membrane (AM) synthesizes a variety of growth factors, cytokines, and vasoactive peptides that modulate inflammation. Read More

View Article
December 2018

Autopsing history: The mummy of Charlemagne (c. 747 - 814 AD), father of Europe.

Econ Hum Biol 2018 Nov 27;32:11-17. Epub 2018 Nov 27.

Institute of Evolutionary Medicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address:

In this article, a complete history of Charlemagne's mortal remains is outlined, including the first publication reporting on the most recent tomb opening in 1988. Besides exclusive bioarchaeological details - namely that his body was indeed mummified - a full clinical interpretation of the Emperor's final illnesses and death is given: a likely combination of osteoarthritis, gout and a recurrent fever caused by an infectious disease. Read More

View Article
November 2018

Racial-Ethnic Differences in Osteoarthritis Pain and Disability: A Meta-Analysis.

J Pain 2018 Dec 10. Epub 2018 Dec 10.

Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL.

Osteoarthritis (OA), a leading cause of disability and pain, affects 32.5 million Americans, producing tremendous economic burden. While some findings suggest that racial/ethnic minorities experience increased OA pain severity, other studies have shown conflicting results. Read More

View Article
December 2018

Exercise therapy in addition to an orthosis reduces pain more than an orthosis alone in patients with thumb base osteoarthritis: a propensity score matching study.

Arch Phys Med Rehabil 2018 Dec 10. Epub 2018 Dec 10.

Dept. of Plastic, Reconstructive and Hand Surgery, Erasmus Medical Center Rotterdam, the Netherlands; Dept. of Rehabilitation Medicine, Erasmus Medical Center Rotterdam, the Netherlands.

Objective: To compare the effect of exercises and orthotics with orthotics alone on pain and hand function in patients with thumb base (CMC-1) osteoarthritis (OA) and to predict outcomes on pain and hand function of exercises and orthotics.

Design: Prospective cohort study with propensity score matching SETTING: Data collection took place in thirteen outpatient clinics for hand surgery and hand therapy in the Netherlands.

Participants: A consecutive, population-based sample of 173 patients with CMC-1 OA was included in this study of which 84 were matched on baseline demographics and baseline primary outcomes. Read More

View Article
December 2018

Supervised physiotherapy leads to a better return to physical activity after anterior cruciate ligament reconstruction.

J Sports Med Phys Fitness 2018 Dec 13. Epub 2018 Dec 13.

Intensive Cardiac Therapy Clinic, Department of Invasive Cardiology and Electrocardiology, Medical University, Lodz, Poland.

Background: The main goal of rehabilitation after anterior cruciate ligament reconstruction (ACLR) is to return to functional and sports activity at a preinjury level. The aim of this study was to assess the influence of supervised (SU) versus non-supervised (NS) rehabilitation protocols after ACLR on the return to sports activity and quality of life of amateur athletes.

Methods: The study included a total of 50 patients after ACLR, with 25 in the SU group and 25 in the NS group. Read More

View Article
December 2018

PI3K/Akt and caspase pathways mediate oxidative stress-induced chondrocyte apoptosis.

Cell Stress Chaperones 2018 Dec 13. Epub 2018 Dec 13.

Department of Orthopedics, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, 213003, China.

Chondrocyte apoptosis is closely related to the development and progression of osteoarthritis (OA); however, the underlying mechanisms remain enigmatic. Previous studies have confirmed that cell apoptosis is one of the main pathological alterations during oxidative stress, and chondrocyte apoptosis induced by oxidative stress plays an important role in the development of OA. Rat chondrocytes exposed to hydrogen peroxide (HO) were used as the experimental oxidative stress model. Read More

View Article
December 2018

Efficacy and Safety of Massage for Osteoarthritis of the Knee: a Randomized Clinical Trial.

J Gen Intern Med 2018 Dec 12. Epub 2018 Dec 12.

Yale-Griffin Prevention Research Center, Griffin Hospital, Yale University School of Public Health, Derby, CT, USA.

Background: Current treatment options for knee osteoarthritis have limited effectiveness and potentially adverse side effects. Massage may offer a safe and effective complement to the management of knee osteoarthritis.

Objective: Examine effects of whole-body massage on knee osteoarthritis, compared to active control (light-touch) and usual care. Read More

View Article
December 2018

Differences of radiocarpal cartilage alterations in arthritis and osteoarthritis using morphological and biochemical magnetic resonance imaging without gadolinium-based contrast agent administration.

Eur Radiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Diagnostic and Interventional Radiology, Medical Faculty, University of Düsseldorf, 40225, Düsseldorf, Germany.

Objectives: To identify differences of radiocarpal cartilage alterations in osteoarthritis and arthritis using multiparametrical magnetic resonance imaging (MRI) comprising morphological and biochemical sequences without gadolinium-based contrast agent administration.

Methods: In this prospective study, multiparametrical MRI of the radiocarpal cartilage was performed in 47 participants (mean age, 46.6 ± 17. Read More

View Article
December 2018

Cartilage repair surgery prevents progression of knee degeneration.

Knee Surg Sports Traumatol Arthrosc 2018 Dec 12. Epub 2018 Dec 12.

Musculoskeletal and Quantitative Imaging Research, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA, 94107, USA.

Purpose: To investigate, whether cartilage repair surgery for focal osteochondral defects at the knee results in less degenerative changes over 6 years in a MR imaging follow-up than morphologically initially identical defects in non-operated control subjects from the osteoarthritis initiative (OAI).

Methods: A total of 32 individuals received baseline and follow-up MRI. In n = 16 patients with cartilage repair [osteochondral autograft transfer system (OATS), n = 12; spongiosa-augmented matrix-associated autologous chondrocyte implantation (MACI), n = 4] MRI was performed preoperatively and after 5. Read More

View Article
December 2018

Patients' expectations of osteotomies around the knee are high regarding activities of daily living.

Knee Surg Sports Traumatol Arthrosc 2018 Dec 12. Epub 2018 Dec 12.

Berufsgenossenschaftliche Unfallklinik Murnau, Murnau, Germany.

Purpose: This study was conducted to investigate patients' expectations on high tibial osteotomies, distal femur osteotomies, and double-level osteotomies in different health-related domains. It was hypothesized that expectations are high in terms of capacity to work, pain relief, and restoring knee function.

Methods: A total of 264 patients (age 47 years ± 11 years) were enrolled in this study from March 2015 until May 2016 in seven specialized orthopaedic surgery departments. Read More

View Article
December 2018

Effect of emodin on chondrocyte viability in an model of osteoarthritis.

Exp Ther Med 2018 Dec 18;16(6):5384-5389. Epub 2018 Oct 18.

Department of Orthopedics, Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang 830000, P.R. China.

Emodin is an anthraquinone isolated from the Chinese herb Radix et Rhizoma Rhei and has been used to treat various diseases for centuries. The aim of the present study was to investigate the effect of emodin on the inflammatory mediators in rat chondrocytes. In the present study, chondrocytes were isolated from rats, cultured and harvested when they reached generation P3. Read More

View Article
December 2018

TNF-α increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate-induced osteoarthritis.

Exp Ther Med 2018 Dec 19;16(6):4737-4744. Epub 2018 Sep 19.

Department of Orthopedics, The Fourth Hospital Affiliated to Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

Osteoarthritis is a degenerative disease that often causes patients to experience joint pain and deformity. It has been demonstrated that tumor necrosis factor (TNF)-α is associated with the progression of osteoarthritis; however, to the best of our knowledge, the mechanisms by which TNF-α simulates the progression of osteoarthritis and the signaling pathway(s) it influences remain unknown. Therefore, the aim of the present study was to investigate the therapeutic effects of TNF-α inhibitor in an iodoacetate-induced rat model of osteoarthritis and identify its potential mechanisms of action. Read More

View Article
December 2018

Abnormal expression of miR-4784 in chondrocytes of osteoarthritis and associations with chondrocyte hyperplasia.

Exp Ther Med 2018 Dec 14;16(6):4690-4694. Epub 2018 Sep 14.

Department of General Dentistry, The 174th Hospital of Chinese PLA, Chenggong Hospital Affiliated to Medical College of Xiamen University, Xiamen, Fujian 361003, P.R. China.

The aim of the present study was to assess the expression of microRNA (miRNA)-4784 in the chondrocytes of early osteoarthritis (OA) and to determine the effect of double-stranded (ds)-miRNA-4784 transfection on chondrocyte function. Following the construction of an OA rabbit model, normal chondrocytes (normal control group), OA chondrocytes obtained 4 weeks after modeling (OA at week 4 group) and 8 weeks after modeling (OA at week 8 group) were used. The relative expression of miRNA-4784 in each group was detected using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Read More

View Article
December 2018

BMP9 overexpressing adipose-derived mesenchymal stem cells promote cartilage repair in osteoarthritis-affected knee joint via the Notch1/Jagged1 signaling pathway.

Exp Ther Med 2018 Dec 18;16(6):4623-4631. Epub 2018 Sep 18.

Department of Orthopedics and Rescue Center of Severe Wound and Trauma of Chinese PLA, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang, Liaoning 110016, P.R. China.

Osteoarthritis (OS) is a common disease in orthopedics. Although OS is known as an inflammation mediated by inflammatory cytokines; however, the mechanism is poorly understood. In the present study, the role of bone morphogenetic protein-9 (BMP9) was investigated in chondrogenic differentiation of adipose-derived mesenchymal stem cells (ADMSCs). Read More

View Article
December 2018

Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.

Front Pharmacol 2018 27;9:1378. Epub 2018 Nov 27.

Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.

Necrostatin-1 (Nec-1) is a specific small molecule inhibitor of receptor-interacting protein kinase 1 (RIPK1) that specifically inhibits phosphorylation of RIPK1. RIPK1 regulates inflammation and cell death by interacting with receptor-interacting serine/threonine protein kinases 3(RIPK3). We hypothesized that Nec-1 may have anti-inflammatory efficacy in patients with osteoarthritis (OA), as the pathophysiology of OA involves the activation of inflammation-related signaling pathways and apoptosis. Read More

View Article
November 2018

Rotational Shortening of Collateral Ligament in TKR With Severe Deformity.

Tech Orthop 2018 Dec 25;33(4):274-278. Epub 2017 Dec 25.

IRCAD/AITS, Changhua.

Instability of the knee joint after total knee replacement (TKR) is one of the most important reasons for revision TKR. Inadequate release or tightening of the collateral ligaments in the knee joint may cause instability and early failure. This study presents a case series study of a new technique for ligament balancing wherein the collateral ligament is detached from its origin and rotated (twisted) around its longitudinal axis to tighten the ligament before the origin is reattached to its original position. Read More

View Article
December 2018

Intra-Articular Injections of Autologous Conditioned Serum to Treat Pain from Meniscal Lesions.

Authors:
Rudolf Strümper

Sports Med Int Open 2017 Oct 29;1(6):E200-E205. Epub 2017 Sep 29.

Privatpraxis Orthopädie im Rheinauhafen, Cologne, Germany.

Routine use of biological therapies is in its early stages. Techniques involve stem cells, platelet preparations, recombinant growth factors and autologous conditioned serum, often combined with surgery. The objective of this case analysis was to document effects of intra-articular autologous conditioned serum injections in outpatients with knee pain associated with meniscal defects. Read More

View Article
October 2017

Magnetic cell delivery for the regeneration of musculoskeletal and neural tissues.

Regen Ther 2018 Dec 2;9:116-119. Epub 2018 Nov 2.

President of Hiroshima University, Higashihiroshima, Japan.

Magnetic targeting is a cell delivery system using the magnetic labeling of cells and the magnetic field; it has been developed for minimally invasive cell transplantation. Cell transplantation with both minimal invasiveness and high efficacy on tissue repair can be achieved by this system. Magnetic targeting has been applied for the transplantation of bone marrow mesenchymal stem cells, blood CD133-positive cells, neural progenitor cells, and induced pluripotent stem cells, and for the regeneration of bone, cartilage, skeletal muscles, and the spinal cord. Read More

View Article
December 2018

Cartilage repair and inhibition of the progression of cartilage degeneration after transplantation of allogeneic chondrocyte sheets in a nontraumatic early arthritis model.

Regen Ther 2018 Dec 24;9:24-31. Epub 2018 Aug 24.

Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.

Introduction: Using a rat model of nontraumatic early arthritis induced by intra-articular administration of low-dose monoiodoacetic acid (MIA), we transplanted allogeneic chondrocyte sheets and examined the effects on tissue repair.

Methods: MIA (0.2 mg/50 μl) was injected into the right knee of 20 male Wistar rats. Read More

View Article
December 2018

Galectins-1 and-3 Increase in Equine Post-traumatic Osteoarthritis.

Front Vet Sci 2018 20;5:288. Epub 2018 Nov 20.

Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.

Galectins are potent regulators of cell adhesion, growth and apoptosis in diverse cell types, including chondrocytes and synovial fibroblasts. Elevations in synovial fluid galectin-3 have been observed in rheumatoid arthritis, juvenile idiopathic arthritis and experimental inflammatory arthritis in animal models, whereas galectin-1 is thought to be protective. Less is known about galectins-1 and-3 in osteoarthritis (OA). Read More

View Article
November 2018

Chondrocyte Intracellular Matrix Strain Fields of Articular Cartilage Surface in Hyperglycemia Model of Rat: Cellular Morphological Study.

Med Arch 2018 Nov;72(5):348-351

Research Group of Smart Molecule of Natural Genetics Resources UB, and Department of Biology, Faculty of Sciences, Brawijaya University.

Introduction: Chondrocyte is one cell in articular cartilage was products many proteins, molecules, and other factors. The external influence of cartilage, such as: hyperglycemia was entering joint capsule and impact to the chondrocytes and the cartilage. Hyperglycemia caused modification of heparan sulfate proteoglycan 2 (perlecan) proteins through glycation process. Read More

View Article
November 2018

In adults with osteoarthritis of the knee, is conservative management more effective than intra-articular corticosteroid injections in relieving pain?

J Okla State Med Assoc 2018 Aug-Sep;111(7):712-713

Saint Anthony Hospital. Family Medicine Residency. Oklahoma City, OK.

Clinical Question: In adults with osteoarthritis of the knee, do conservative management methods such as weight reduction, physical therapy, Tai Chi, non-steroidal anti-inflammatory drugs (NSAIDs), and others provide more and longer pain relief and functionality of the knee, as well as overall well-being, when compared to corticosteroid knee injections?

Answer: Yes. Although there are limited head-to-head trials directly comparing each alternative method to corticosteroid injections, overall evidence appears to indicate conservative methods as being more effective than injections, especially when considering long-term pain relief and functionality. Read More

View Article
December 2018

Long-term deterioration after one-stage unicompartmental knee arthroplasty and anterior cruciate ligament reconstruction.

Musculoskelet Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Orthopaedic Surgery, Fundació Hospital de l'Esperit Sant, Av. Mossèn Pons i Rabadà s/n, 08923, Santa Coloma de Gramenet, Barcelona, Spain.

Purpose: Treatment for unicompartmental knee osteoarthritis (OA) is controversial in young patients with concomitant anterior cruciate ligament (ACL) deficiency. The aim of the current study is to report long-term results after the combination of unicompartmental knee arthroplasty (UKA) and ACL reconstruction.

Methods: Retrospective study of one-stage medial UKA and ACL reconstruction was performed on eight patients at a mean age of 52 years (42-60). Read More

View Article
December 2018

Treatment of unstable knee osteochondritis dissecans in the young adult: results and limitations of surgical strategies-The advantages of allografts to address an osteochondral challenge.

Knee Surg Sports Traumatol Arthrosc 2018 Dec 6. Epub 2018 Dec 6.

Department of Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, Oregon, USA.

Joint surface incongruence resulting from osteochondritis dissecans (OCD) alters the articular physiologic congruence, increasing the contact stress on adjacent joint surfaces and accelerating wear and the cascade of joint degeneration. Accordingly, the restoration of articular surface integrity is of major importance, especially in young adults where, in lesions left untreated or following simple fragment excision, early osteoarthritis can be anticipated. Therefore, the treatment algorithm in unstable knee OCD of the young adult foresees surgical options to restore the articular surface. Read More

View Article
December 2018

Machine-learning-based patient-specific prediction models for knee osteoarthritis.

Nat Rev Rheumatol 2018 Dec 6. Epub 2018 Dec 6.

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.

Osteoarthritis (OA) is an extremely common musculoskeletal disease. However, current guidelines are not well suited for diagnosing patients in the early stages of disease and do not discriminate patients for whom the disease might progress rapidly. The most important hurdle in OA management is identifying and classifying patients who will benefit most from treatment. Read More

View Article
December 2018

Metabolic fingerprinting for diagnosis of fibromyalgia and other rheumatologic disorders.

J Biol Chem 2018 Dec 6. Epub 2018 Dec 6.

The Ohio State University, Food Science and Technology, United States.

Diagnosis and treatment of Fibromyalgia (FM) remains a challenge owing to the lack of reliable biomarkers. Our objective was to develop a rapid biomarker-based method for diagnosing FM by using vibrational spectroscopy to differentiate patients with FM from those with Rheumatoid Arthritis (RA), Osteoarthritis (OA) or Systemic Lupus Erythematosus (SLE), and to identify metabolites associated with these differences. Blood samples were collected from patients with a diagnosis of FM (n=50), RA (n=29), OA (n=19), or SLE (n=23). Read More

View Article
December 2018

Prominin-1 controls stem cell activation by orchestrating ciliary dynamics.

EMBO J 2018 Dec 6. Epub 2018 Dec 6.

Peninsula Dental School, University of Plymouth, Plymouth, UK

Proper temporal and spatial activation of stem cells relies on highly coordinated cell signaling. The primary cilium is the sensory organelle that is responsible for transmitting extracellular signals into a cell. Primary cilium size, architecture, and assembly-disassembly dynamics are under rigid cell cycle-dependent control. Read More

View Article
December 2018