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Complement Ther Clin Pract 2019 May 4;35:121-125. Epub 2019 Feb 4.

Department of Joint Surgery, Affiliated Hospital of Jining Medical University, Jining, 272029, Shandong, PR China. Electronic address:

Background And Purpose: Postoperative rehabilitation plays an indispensable role for a successful total knee arthroplasty (TKA) and the optimal exercises programs are not known. A single-centre, single-blind, randomised controlled trial was designed to explore whether tai chi chuan (TCC) exercises can improve the functional outcomes and the quality of life (QOL) in patients with primary TKA due to knee osteoarthritis (OA).

Materials And Methods: One hundred seven participants with primary TKA for end-stage knee OA were enrolled from January 2014 to January 2017. Read More

Gait Posture 2019 Apr 6;71:20-25. Epub 2019 Apr 6.

Clinic for Orthopedics and Trauma Surgery, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany. Electronic address:

Purpose: The purpose of this study was to examine how total shoulder arthroplasty improves performance of activities of daily living compared to patients with glenohumeral osteoarthritis and how they perform compared to healthy controls.

Methods: Glenohumeral and humerothoracical elevation used by patients with primary osteoarthritis (12 participants, 16 shoulders), after total shoulder arthroplasty (16 participants, 24 shoulders) and healthy controls (11 participants, 22 shoulders) for four different activities of daily living were assessed using 3D motion analysis. Analysis of range of motion and angle time series was performed. Read More

Osteoarthritis Cartilage 2019 Apr 16. Epub 2019 Apr 16.

AO Research Institute Davos, Switzerland. Electronic address:

Objective: This study aimed to characterize the mesenchymal stem cell (MSC) subpopulation migrating towards a degenerated intervertebral disc (IVD) and to assess its regenerative potential.

Design: Based on initial screening for migration towards chemokine ligand 5 (CCL5), the migration potential of CD146+ and CD146- MSCs was evaluated in vitro and in a degenerated organ culture model (degeneration by high-frequency loading in a bioreactor). Discogenic differentiation potential of CD146+ and CD146- MSCs was investigated by in vitro pellet culture assay with supplementation of growth and differentiation factor-6 (GDF6). Read More

Evid Based Complement Alternat Med 2019 14;2019:1291947. Epub 2019 Mar 14.

School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Objective: The aim of this study was to investigate the difference of efficacy between conventional moxibustion (CM) and smoke-free moxibustion (SM) for patients with osteoarthritis of the knee (KOA).

Methods: This is a multicentre, randomized, single blinded, parallel-group clinical trial. Patients with KOA were randomly allocated to CM group (69) and SM group (69) in 7 hospitals of China. Read More

Arthroscopy 2019 Apr 15. Epub 2019 Apr 15.

Department of Orthopedics, Rush University Medical Center, Chicago, Illinois, U.S.A.. Electronic address:

Purpose: The purpose of this study was to establish minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient-acceptable symptom state (PASS) after meniscectomy and factors associated with achieving these goals.

Methods: A prospectively maintained institutional registry was retrospectively reviewed for all patients undergoing isolated arthroscopic partial meniscectomy from 2014 through 2017. MCID, SCB, and PASS were calculated for the International Knee Documentation Committee (IKDC) and Knee Injury and Osteoarthritis Outcome Score (KOOS) subscores by using the anchor-based methodology and nonparametric receiver operating characteristic curves. Read More

Pilot Feasibility Stud 2019 6;5:54. Epub 2019 Apr 6.

1School of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, B15 2TT UK.

Background: Osteoarthritis is a highly prevalent condition in older adults, that causes many sufferers to require a hip or knee replacement in order to improve their quality of life and reduce pain. Individuals waiting for hip or knee replacements are often highly sedentary; thus, it is pertinent to assess whether reducing their sedentariness prior to surgery may aid in improving post-operative outcomes.

Methods/design: The study will be a randomised controlled feasibility trial design, with 2:1 randomisation into an intervention and usual care group respectively. Read More

J Orthop 2019 Jul-Aug;16(4):342-346. Epub 2019 Mar 24.

Department of Orthopedics Tergooiziekenhuizen, Van Riebeeckweg 212, 1213, XZ, Hilversum, the Netherlands.

Background: Purpose of this study was to evaluate the long - term survivorship and clinical and radiological results of a primary reverse total shoulder arthroplasty (RTSA) performed with uncemented stems.

Methods: From 2001 until 2006 61 primary uncemented RTSAs were implanted, which were included in a Kaplan-Meier survival analysis. Range of motion, functional scores and radiological follow - up was obtained. Read More

J Orthop 2019 Jul-Aug;16(4):334-336. Epub 2019 Mar 26.

Department of Orthopaedic Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Purpose: We compared the outcome of total hip arthroplasty (THA) in this age group using direct anterior or posterior approach.

Methods: We performed a retrospective analysis following consecutive primary THA in patients over 80 years.

Results: The DAA group demonstrated significantly shorter length of stay, better functional improvement, no dislocation or revision while PA group required two revisions due to dislocation. Read More

Osteoarthritis Cartilage 2019 Apr 14. Epub 2019 Apr 14.

Clinical Epidemiology, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, UK. Electronic address:

Objective: To determine the natural history of flare-ups in knee osteoarthritis and their relation to physical exposures.

Design: Adults aged ≥45 years with a recent primary care consultation for knee OA/arthralgia completed a daily pen-and-paper diary for up to 3 months, including questions on average knee pain intensity, pain descriptors, other symptoms, activity interference, and selected physical exposures (prolonged kneeling, squatting, climbing stairs, ladders, and moving/lifting heavy objects). Informed by a systematic review, flare-ups were defined a priori. Read More

Toxicon 2019 Apr 14. Epub 2019 Apr 14.

Aja University of Medical Sciences, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Islamic Republic of Iran. Electronic address:

In recent years, there is a growing interest in new medical applications of botulinum toxin, including pain control, osteoarthritis treatment, and wound healing. While clinical applications of botulinum toxin seem promising, existing evidence regarding the therapeutic effects is still inadequate. The aim was to assess the efficacy of a single injection of abobotulinumtoxin A into the knee joint cavity to reduce pain in elderly people. Read More

Acta Orthop 2019 Apr 17:1-9. Epub 2019 Apr 17.

b The Swedish Knee Arthroplasty Register , Lund , Sweden.

Background and purpose - Patient-reported outcome (PRO) in total knee arthroplasty (TKA) patients with high body mass index (BMI) is controversial. We compared pain, function, quality of life, general health, and satisfaction among different BMI categories preoperatively and 1 year after primary TKA. Patients and methods - 4,318 patients were operated with a TKA for knee osteoarthritis in the Region of Skane in 2013-2015. Read More

Intern Med J 2019 Apr 16. Epub 2019 Apr 16.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.

Background: Knee osteoarthritis (OA) is one of the most common joint diseases, and pharmacotherapy is necessary to control its symptoms.

Aim: To evaluate efficacy and tolerability of duloxetine in patients with knee OA.

Methods: PubMed, Web of Science, Embase, Cochrane Library, and ClinicalTrials. Read More

Oper Orthop Traumatol 2019 Apr 12. Epub 2019 Apr 12.

Fabricius Klinik, Gelenkzentrum Bergisch Land, Freiheitstsr. 203, 42853, Remscheid, Germany.

Objective: Portal assisted minimally invasive total hip arthroplasty without dislocation of the femoral head with preservation of the hip capsule and the external rotators in the lateral decubitus position for rapid recovery with the option of expandability to a mini posterior or classic posterolateral approach at any time.

Indications: Primary and secondary arthritis of the hip, femoral head necrosis, femoral neck fracture.

Contraindications: Severe anatomical disorders of the proximal femur, congenital high hip dysplasia, implanted hardware in the trochanteric region, local and systemic infections. Read More

Am J Sports Med 2019 Apr 15:363546519835800. Epub 2019 Apr 15.

Division of Sports and Shoulder, Hospital for Special Surgery, New York, New York, USA.

Background: It is unclear which patients with recurrent patellar instability require a bony procedure in addition to medial patellofemoral ligament (MPFL) reconstruction.

Purpose: To report 1- and 2-year outcomes of patients after isolated MPFL reconstruction performed for patellar instability regardless of patellar height, tibial tubercle-trochlear groove (TT-TG) distance, or trochlear dysplasia.

Study Design: Case series; Level of evidence, 4. Read More

Cartilage 2019 Apr 13:1947603519841674. Epub 2019 Apr 13.

5 Biose®, R&D Department, Arpajon-sur-Cère, France.

Objective: The aim of this study was to evaluate the effects of a lyophilized inactivated culture (LIC) from Bifidobacterium longum CBi0703 in a spontaneous model of osteoarthritis (OA) in Dunkin Hartley guinea pigs. Histology of cartilage and synovial membrane was the primary outcome. Biomarkers were also considered to evaluate the treatment efficacy. Read More

Clin Oral Investig 2019 Apr 13. Epub 2019 Apr 13.

Department of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Objectives: The aim was to determine the frequency of Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD)-based pain diagnoses and dynamic/static tests-based pain diagnoses, and to assess the agreement of palpation tests with static/dynamic tests.

Materials And Methods: Eighty-six (N = 86) adult patients with Lyme disease (mean age 57.0 ± 14. Read More

Physiotherapy 2019 Jan 26. Epub 2019 Jan 26.

VUmc, Department of Rehabilitation Medicine, Amsterdam, Netherlands. Electronic address:

Objectives: To explore the feasibility of a newly developed model of stratified exercise therapy in primary care for patients with knee osteoarthritis (OA).

Design: Mixed method design (process, outcome and qualitative evaluation).

Setting: Six physical therapy practices in primary care around Amsterdam. Read More

Can Fam Physician 2019 Apr;65(4):260-263

Director of Programs and Practice Support for the College of Family Physicians of Canada and Professor in the Department of Family Medicine at the University of Alberta.

Objective: To summarize high-quality studies for 10 topics from 2018 that have strong relevance to primary care practice.

Quality Of Evidence: Study selection involved routine literature surveillance by a group of primary care health professionals. This included screening abstracts of important journals and Evidence Alerts, as well as searching . Read More

J Arthroplasty 2019 Feb 20. Epub 2019 Feb 20.

Hospital for Special Surgery, Healthcare Research Institute, New York, NY.

Background: Patient-reported outcome measures (PROMs) help assess therapeutic effectiveness. This study assessed the effect of advanced age on the Hip Disability and Osteoarthritis Outcome Score (HOOS) and Lower Extremity Activity Scale (LEAS) after total hip arthroplasty (THA).

Methods: A prospective cohort of patients underwent primary THA at our institution between May 2007 and December 2011. Read More

Osteoarthritis Cartilage 2019 Apr 9. Epub 2019 Apr 9.

Departments of Rheumatology, Leiden University Medical Center (LUMC), Leiden, the Netherlands; Clinical Epidemiology, Leiden University Medical Center (LUMC), Leiden, the Netherlands. Electronic address:

Objective: To investigate determinants of decrease and increase in joint pain in symptomatic finger osteoarthritis (OA) on magnetic resonance (MR) imaging over 2 years.

Design: Eighty-five patients (81.2% women, mean age 59. Read More

JSES Open Access 2019 Mar 24;3(1):37-42. Epub 2018 Dec 24.

Centre Orthopédique Santy, Lyon, France.

Background: In patients with osteoarthritis (OA) and an intact rotator cuff, hemi-shoulder arthroplasty (HSA) can be a viable option as it offers the advantage of keeping the native glenoid intact. However, glenoid erosion has frequently been reported. The aim of this study was to report preliminary clinical results of HSA with a new pyrolytic carbon (pyrocarbon) humeral head. Read More

Mol Syndromol 2019 Feb 21;10(1-2):98-114. Epub 2018 Jul 21.

Genetics and Genomic Medicine, UCL Institute of Child Health, London, UK.

Neural crest stem/progenitor cells (NCSCs) populate a variety of tissues, and their dysregulation is implicated in several human diseases including craniosynostosis and neuroblastoma. We hypothesised that small molecules that inhibit NCSC induction or differentiation may represent potential therapeutically relevant drugs in these disorders. We screened 640 FDA-approved compounds currently in clinical use for other conditions to identify those which disrupt development of NCSC-derived skeletal elements that form the zebrafish jaw. Read More

Acta Orthop 2019 Apr 11:1-10. Epub 2019 Apr 11.

a Department of Orthopaedic Surgery, Clinical Orthopaedic Research Hvidovre (CORH) , Copenhagen University Hospital Hvidovre , Denmark ;

Background and purpose - Using contemporary indications, up to 50% of patients undergoing knee arthroplasty are eligible for unicompartmental knee arthroplasty (UKA), and lower UKA use likely reflects a restrictive approach to patient selection. Since broader indications have been successfully introduced, and low surgical volume and UKA percentage (usage) are associated with higher revision rates, it is of interest whether the actual use of UKA has changed accordingly. We explored this by assessing time trends in patient demographics and whether these are associated with center UKA volume and usage. Read More

Foot Ankle Int 2019 Apr 11:1071100719840816. Epub 2019 Apr 11.

1 Department of Orthopedic Surgery, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea.

Background: Total ankle arthroplasty is often not recommended to younger patients with ankle arthritis because of their high functional demands. The purpose of this study was to compare intermediate-term clinical and radiographic outcomes and survivorship rates of total ankle arthroplasty between patients younger and older than 55 years.

Methods: A total of 117 consecutive patients (123 ankles) who underwent primary total ankle arthroplasty using Hintegra prosthesis with a mean follow-up of 78 months were enrolled and divided into 2 age groups: under 55 years (38 ankles; mean age 45 years) and over 55 years (85 ankles; mean age 65 years). Read More

Cartilage 2019 Apr 11:1947603519841673. Epub 2019 Apr 11.

1 Department of Orthopaedic Surgery, University of California, Los Angeles, Santa Monica, CA, USA.

Objective: Successful clinical outcomes following cartilage restoration procedures are highly dependent on addressing concomitant pathology. The purpose of this study was to document methods for evaluating concomitant procedures of the knee when performed with articular cartilage restoration techniques, and to review their reported findings in high-impact clinical orthopedic studies. We hypothesized that there are substantial inconsistencies in reporting clinical outcomes associated with concomitant procedures relative to outcomes related to isolated cartilage repair. Read More

ANZ J Surg 2019 Apr 9. Epub 2019 Apr 9.

Department of Orthopaedic Surgery and Musculoskeletal Medicine, Christchurch Public Hospital, Christchurch, New Zealand.

Background: Surgical management options for bilateral knee osteoarthritis comprise staged or single-anaesthetic bilateral total knee replacements (SABTKRs). We examined the New Zealand Joint Registry hypothesizing there would be no difference between these practices compared to unilateral total knee replacement (TKR) examining 30-day mortality, all-cause revision rate and function.

Methods: For this study, 84 946 primary TKRs were identified. Read More

BMC Musculoskelet Disord 2019 Apr 9;20(1):158. Epub 2019 Apr 9.

Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.

Background: Chronic low back pain (cLBP) affects millions of Americans and costs billions. Studies suggest a link between cLBP and joint hypermobility.

Methods: We conducted cross-sectional primary analyses of joint hypermobility and cLBP, lumbar spine osteoarthritis (OA), and lumbar facet joint OA (FOA) in 3 large studies-the Generalized Osteoarthritis Study, Genetics of Generalized Osteoarthritis Study, and Johnston County Osteoarthritis Project (total n = 5072). Read More

BMC Musculoskelet Disord 2019 Apr 9;20(1):159. Epub 2019 Apr 9.

Bone Joint and Trauma Clinic, Darbhanga, India.

Background: Previous studies reported the beneficial effects of walking in individual with mild to moderate knee osteoarthritis (OA). The current study aimed to compare the effect of 6-week retro versus forward walking program versus control group on pain, functional disability, quadriceps muscle strength and physical performance in individuals with knee OA.

Methods: A three-arm single-blinded, randomized, controlled trial and intention-to-treat analysis was conducted in outpatient physiotherapy department, King Saud University, Saudi Arabia. Read More

Sci Rep 2019 Apr 8;9(1):5761. Epub 2019 Apr 8.

Insight Centre for Data Analytics, National University of Ireland Galway, Galway, Ireland.

Knee osteoarthritis (KOA) is a disease that impairs knee function and causes pain. A radiologist reviews knee X-ray images and grades the severity level of the impairments according to the Kellgren and Lawrence grading scheme; a five-point ordinal scale (0-4). In this study, we used Elastic Net (EN) and Random Forests (RF) to build predictive models using patient assessment data (i. Read More

BMJ Open 2019 Apr 8;9(4):e026084. Epub 2019 Apr 8.

Department of Orthopaedics, Guanghua Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Introduction: The purpose of this study is to assess the efficacy of electroacupuncture (EA) to relieve pain and promote functional rehabilitation after total knee surgery.

Methods And Analysis: We propose a single-blinded, randomised placebo-controlled trial to evaluate the efficacy of EA. Patients with osteoarthritis (aged 55-80 years) undergoing unilateral total knee arthroplasty (TKA) will be included in the trial. Read More

BMC Musculoskelet Disord 2019 Apr 9;20(1):151. Epub 2019 Apr 9.

Australasian College of Sport and Exercise Physicians, 257 Collins Street, Melbourne, VIC, 3000, Australia.

Background: There is no cure for knee osteoarthritis (KOA) and typically patients live approximately 30-years with the disease. Most common medical treatments result in short-term palliation of symptoms with little consideration of long-term risk. This systematic review aims to appraise the current evidence for the long-term (≥12 months) safety of common treatments for knee osteoarthritis (KOA). Read More

Int J Mol Sci 2019 Apr 6;20(7). Epub 2019 Apr 6.

Department of Thoracic and Cardiovascular Surgery, University Hospital Tübingen, Calwerstraße 7/1, 72076 Tübingen, Germany.

Musculoskeletal disorders, such as osteoarthritis and intervertebral disc degeneration are causes of morbidity, which concomitantly burdens the health and social care systems worldwide, with massive costs. Link N peptide has recently been described as a novel anabolic stimulator for intervertebral disc repair. In this study, we analyzed the influence on anabolic response, by delivering synthetic Link N encoding mRNA into primary human chondrocytes and mesenchymal stromal cells (SCP1 cells), Furthermore, both cell types were seeded on knitted titanium scaffolds, and the influence of Link N peptide mRNA for possible tissue engineering applications was investigated. Read More

Nutrients 2019 Apr 5;11(4). Epub 2019 Apr 5.

Department of Neuroscience, University of Padova, 35122 Padova, Italy.

Few studies assessed the associations between dietary vitamin K and depressive symptoms. We aimed to investigate the association between dietary vitamin K and depressive symptoms in a large cohort of North American People. In this cross-sectional analysis, 4,375 participants that were aged 45⁻79 years from the Osteoarthritis Initiative were included. Read More

J Knee Surg 2019 Apr 8. Epub 2019 Apr 8.

University College London Hospitals NHS Foundation Trust, London, United Kingdom.

The use of valgus-varus constrained (VVC) implant designs in primary total knee arthroplasty (TKA) is considered in situations of severe deformities, bone loss, and inadequate soft tissue balance. It is not known whether the use of such prosthesis designs may predispose to reduced function owing to its constraining design. The components are usually implanted with diaphyseal stem extensions to dissipate the increased forces. Read More

PLoS One 2019 8;14(4):e0215035. Epub 2019 Apr 8.

Department of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Obese patients are more likely to develop periprosthetic joint infection (PJI) after primary total joint arthroplasty. This study compared the clinical and microbiological characteristics of non-obese, obese and severely obese patients with early PJI, in order to ultimately optimize antibiotic prophylaxis and other prevention measures for this specific patient category.

Methods: We retrospectively evaluated patients with early PJI of the hip and knee treated with debridement, antibiotics and implant retention (DAIR) between 2006 and 2016 in three Dutch hospitals. Read More

Clin Rehabil 2019 Apr 8:269215519840406. Epub 2019 Apr 8.

1 Physical Therapy Department, Neuromuscular Plasticity Laboratory, Federal University of São Carlos, São Paulo, Brazil.

Objective: To investigate the effectiveness of cryotherapy on pain and physical function in knee osteoarthritis.

Data Sources: An electronic search was performed up to February 2019 on PubMed/MEDLINE, EMBASE, CINAHL, Lilacs, Cochrane, Web of Science, Ibecs, and Scielo databases with keywords knee osteoarthritis and cryotherapy.

Methods: Two authors independently performed the study selection. Read More

Acta Orthop Traumatol Turc 2019 Apr 4. Epub 2019 Apr 4.

Ethianum Clinic Heidelberg, Voßstr. 6, Heidelberg, Germany.

Objective: The introduction of a stemless prosthesis in shoulder arthroplasty represents a novel design whereby the proximal humerus is restored anatomically, while leaving the diaphysis of the humerus untouched. The aim of this study was to present the mid-term results of total evolutive shoulder system (TESS; Biomet), a stemless shoulder prosthesis.

Methods: The study included 38 consecutive patients (18 men and 20 women; mean age: 66 years; range: 55-81 years) treated with shoulder arthroplasty between 2009 and 2011 with TESS for primary glenohumeral arthritis. Read More

J Orthop Surg (Hong Kong) 2019 May-Aug;27(2):2309499019840827

1 Department of Orthopaedic Surgery, Kyung Hee University Hospital, Seoul, Korea.

Purpose:: To compare the long term outcomes of transtibial nonanatomic single-bundle (SB) and double-bundle (DB) anterior cruciate ligament (ACL) reconstruction.

Methods:: Between January 2008 and September 2010, we retrospectively evaluated 377 patients who underwent primary ACL reconstruction and who were available at 8 years of follow-up. Patients who received transtibial nonanatomic SB ACL reconstruction ( n = 263) were assigned to group SB and DB ACL reconstruction ( n = 114) to group DB. Read More

Acta Orthop 2019 Apr 8:1-12. Epub 2019 Apr 8.

b Department of Orthopaedics , Institute of Surgical Science, Sahlgrenska University Hospital, Gothenburg University , Mölndal , Sweden.

Background and purpose - Uncemented cups in total hip arthroplasty (THA) are often augmented with additional screws to enhance their primary stability. We investigated whether there is a difference in the risk for revision between cups with screw holes and cups without screw holes. Patients and methods - We analyzed the risk for cup revision of uncemented cups registered in the Swedish Hip Arthroplasty Register (SHAR) between 2000 and 2017 with respe ct to the presence of screw holes. Read More

Life Sci 2019 Apr 3. Epub 2019 Apr 3.

Department of Bone and Joint Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China. Electronic address:

Diabetes is an independent risk factor for knee osteoarthritis (OA), and hyperglycaemia-induced inflammation is considered to play an important role in their connection. The Toll-like receptor 4 (TLR4) regulates inflammatory responses in several pathological conditions including diabetes and OA. However, its role in diabetes-associated OA is poorly understood. Read More

Biomed Res Int 2019 5;2019:3904923. Epub 2019 Mar 5.

Department of Orthopedics, The Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha 410011, China.

Background And Aims: A growing body of research has demonstrated that the degeneration of chondrocytes is the primary cause of osteoarthritis (OA). Parathyroid hormone-related protein (PTHrP) can alleviate the degeneration of chondrocytes via promotion of chondrocyte proliferation and inhibition of terminal differentiation, but the underlying mechanism remains unknown. This study aimed to identify the microRNAs (miRNAs) that may target PTHrP and regulate the proliferation and terminal differentiation of chondrocytes. Read More

Medicine (Baltimore) 2019 Apr;98(14):e15119

Second Ward of Orthopedis Department, First Affiliated Hospital of Jiamusi University, Jiamusi.

Background: Previous clinical studies have reported that extracorporeal shock wave (EPSW) monotherapy can effectively treat avascular necrosis of femoral head (ANFH). However, no systematic review has been conducted to assess its effectiveness and safety for patients with ANFH. Therefore, this study will systematically assess the effectiveness and safety of EPSW monotherapy for patients with ANFH. Read More

J Bone Joint Surg Am 2019 Apr;101(7):580-588

Department of Orthopaedics, Prince Charles Hospital, Chermside, Queensland, Australia.

Background: Computer navigation and image-derived instrumentation (IDI) are technology-based methods developed to improve outcomes and potentially reduce revision total knee arthroplasty (TKA). IDI refers to the use of manufactured, patient-specific surgical jigs. Conflicting reports exist on IDI-associated improvements in outcomes. Read More

Knee Surg Sports Traumatol Arthrosc 2019 Apr 3. Epub 2019 Apr 3.

II Orthopaedic Clinic and Biomechanics Laboratory, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano n. 1/10, 40136, Bologna, Italy.

Purpose: To report clinical and functional results of ACL reconstruction in patients over 50 years old and investigate the influence of surgery on osteoarthritis progression in this cohort of patients.

Methods: A systematic review was performed on PubMed, Scopus, Google scholar, Cochrane library and EMBASE, using a strategy search design to collect clinical studies reporting outcomes of ACL reconstruction in patients aged 50 years or older. The primary outcome measure was clinical and functional results, including failure rate defined as reoperation for revision ACL surgery or conversion to total knee arthroplasty; secondary outcomes included radiological findings, expressed according to the validated grading score. Read More

JCI Insight 2019 Apr 4;4(7). Epub 2019 Apr 4.

Translational Tissue Engineering Center, Wilmer Eye Institute, and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

Senescent cells (SnCs) are increasingly recognized as central effector cells in age-related pathologies. Extracellular vesicles (EVs) are potential cellular communication tools through which SnCs exert central effector functions in the local tissue environment. To test this hypothesis in a medical indication that could be validated clinically, we evaluated EV production from SnCs enriched from chondrocytes isolated from human arthritic cartilage. Read More

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1256-1264

a Department of Orthopaedics , The Second Hospital of Jilin University , Changchun , Jilin , China.

Osteoarthritis (OA) poses a growing threat to the health of the global population. Accumulation of advanced glycation end-products (AGEs) has been shown to upregulate expression of degradative enzymes such as matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) in chondrocytes, which leads to excessive degradation of type II collagen and aggrecan in the articular extracellular matrix (ECM). In the present study we investigated the effects of the GLP-1 agonist lixisenatide, a widely used type II diabetes medication, on AGEs-induced decreased mitochondrial membrane potential (MMP), degradation of ECM, oxidative stress, expression of cytokines including interleukin (IL)-1β and IL-6, and activation of nuclear factor kappa B (NF-κB). Read More

J Sci Med Sport 2019 Mar 16. Epub 2019 Mar 16.

Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, UK.

Objectives: This study aimed to determine the prevalence of hand and wrist osteoarthritis in former elite cricket and rugby union players, by sport and playing position, and to define the prevalence of severe hand injury, and its association with hand osteoarthritis.

Design: Cross-sectional.

Methods: Data from cross-sectional studies of former elite male cricket and rugby players were used to determine the prevalence of hand pain, physician-diagnosed osteoarthritis, and previous severe injury. Read More

J Orthop Surg (Hong Kong) 2019 May-Aug;27(2):2309499019838668

1 Department of Orthopaedics, University of Szeged, Szeged, Hungary.

Purpose:: Metaphyseal, proximally anchored uncemented stems for total hip arthroplasty provide bone preservation and decrease the incidence of proximal stress shielding and thigh pain. Our study investigated the clinical and radiological outcome of the DePuy Proxima™ short stem at a minimum of 7 years.

Methods:: Eighty-one consecutive patients (86 procedures) under the age of 70 undergoing primary total hip replacement at two arthroplasty centres were enrolled. Read More

Inflammation 2019 Apr 1. Epub 2019 Apr 1.

Oral Biology Research Institute, School of Dentistry, Chosun University, 309 Philmun-daero, Dong-gu, Gwangju, 61452, Republic of Korea.

In the present study, we demonstrated the anti-catabolic effects of formononetin, a phytoestrogen derived from herbal plants, against interleukin-1β (IL-1β)-induced severe catabolic effects in primary rat chondrocytes and articular cartilage. Formononetin did not affect the viability of primary rat chondrocytes in both short- (24 h) and long-term (21 days) treatment periods. Furthermore, formononetin effectively antagonized the IL-1β-induced catabolic effects including the decrease in proteoglycan content, suppression of pericellular matrix formation, and loss of proteoglycan through the decreased expression of cartilage-degrading enzymes like matrix metalloproteinase (MMP)-13, MMP-1, and MMP-3 in primary rat chondrocytes. Read More

Orthop J Sports Med 2019 Mar 25;7(3):2325967119833715. Epub 2019 Mar 25.

American Hip Institute, Des Plaines, Illinois, USA.

Background: Labral reconstruction has been described as a solution for the irreparable labrum. Initial techniques employed autografts, while more recent procedures have utilized allografts. No study, to our knowledge, has compared graft types. Read More