Search Our Scientific Publications & Authors

Clin Podiatr Med Surg 2019 Apr 24;36(2):295-306. Epub 2019 Jan 24.

Department of Trauma, Hand and Reconstructive Surgery, Rostock University Medical Center, Schillingallee 35, Rostock D-18057, Germany. Electronic address:

Primary or secondary subtalar joint arthrodesis after displaced intra-articular calcaneal fractures makes use of talocalcaneal large-diameter screw fixation after an eventual correction of geometric hindfoot deformity. Despite this procedure usually having a successful functional outcome, potential complications occur, including nonunion and malalignment, with an unknown rate of loss of correction or implant migration during the healing period. Angular stable fixation of the subtalar joint arthrodesis with an interlocking nail applied in a minimally invasive technique affords maintenance of the hindfoot position until osseous healing occurs. Read More

BMJ Open 2019 Feb 18;9(2):e028365. Epub 2019 Feb 18.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.

Introduction: Osteoporosis is a systemic skeletal disease that is characterised by reduced bone strength and increased fracture risk. Osteoporosis-related fractures impose enormous disease and economic burden to the society. Although many treatments and health interventions are proven effective to prevent fractures, health economic evaluation adds evidence to their economic merits. Read More

BMJ Open 2019 Feb 1;9(1):e024016. Epub 2019 Feb 1.

Department of Community Health Sciences, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.

Objective: To elicit perspectives of family physicians and patients with knee osteoarthritis (KOA) on KOA, its treatment/management and the use of a mobile health application (app) to help patients self-manage their KOA.

Design: A qualitative study using Cognitive Task Analysis for physician interviews and peer-to-peer semistructured interviews for patients according to the Patient and Community Engagement Research (PaCER) method.

Setting: Primary care practices and patient researchers at an academic centre in Southern Alberta. Read More

BMJ Open 2019 Jan 9;9(1):e022553. Epub 2019 Jan 9.

Methodologist, centre de Recherche Clinique, CHD Vendée, La Roche-sur-Yon, Pays de la Loire, France.

Introduction: Osteoarthritis of the trapeziometacarpal joint affects approximately 10%-25% of women, especially those who are postmenopausal. It may result in thumb dysfunction. Among the treatments, intra-articular injections of corticosteroid (CS) and hyaluronic acid (HA) are both effective and recommended. Read More

Lancet 2019 Feb 14;393(10172):655-663. Epub 2019 Feb 14.

Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Southmead Hospital, Bristol, UK; National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals, Bristol NHS Foundation Trust, University of Bristol, Bristol, UK.

Background: Knee replacements are the mainstay of treatment for end-stage osteoarthritis and are effective. Given time, all knee replacements will fail and knowing when this failure might happen is important. We aimed to establish how long a knee replacement lasts. Read More

Lancet 2019 Feb 14;393(10172):647-654. Epub 2019 Feb 14.

Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, Southmead Hospital, Bristol, UK.

Background: Total hip replacement is a common and highly effective operation. All hip replacements would eventually fail if in situ long enough and it is important that patients understand when this might happen. We aimed to answer the question: how long does a hip replacement last?

Methods: We did a systematic review and meta-analysis with a search of MEDLINE and Embase from the start of records to Sept 12, 2017. Read More

Dtsch Arztebl Int 2019 Jan;116(1-2):1-8

University Center of Orthopedic and Trauma Surgery, TU Dresden, Section Sports Medicine and Rehabilitation, Dresden; University Center of Orthopedic and Trauma Surgery, TU Dresden, Dresden.

Background: Sport rehabilitation is a reimbursable intervention assisting reintegration and self-help. In this study, we measured the effects of sport rehabilitation on muscle strength around the hip joint at 1 year after surgery, as well as cardiopulmonary endurance performance and stability of stance, in patients who had undergone a first implantation of a total hip endoprosthesis (total hip replacement, THR) as a treatment for osteoarthritis of the hip.

Methods: 160 patients were randomly allotted either to an intervention group with intensive sport rehabilitation for the first year or to a control group. Read More

Trials 2019 Feb 19;20(1):140. Epub 2019 Feb 19.

Department of Internal Medicine, Dunsan Korean Medicine Hospital of Daejeon University, 75, Daedeok-daero 176 beon-gil, Seo-gu, Daejeon, 35235, South Korea.

Background: Degenerative knee osteoarthritis is a leading cause of disability in the elderly. If patients do not respond to pharmacological or nonpharmacological intervention, total knee replacement surgery is recommended. However, owing to the contraindications and adverse effects of surgery, the need for a new treatment strategy is emerging. Read More

Clin Rehabil 2019 Feb 19:269215519827996. Epub 2019 Feb 19.

1 Rheumatology Division, Escola Paulista de Medicina (UNIFESP-EPM), Universidade Federal de São Paulo, São Paulo, Brazil.

Objective:: To compare the effectiveness of intra-articular injection (IAI) with Botulinum toxin type A (BTA), triamcinolone hexacetonide (TH), and saline in primary knee osteoarthritis.

Design:: A randomized controlled trial, with blinded patients and assessor.

Setting:: Outpatient rheumatology service. Read More

J Arthroplasty 2019 Jan 31. Epub 2019 Jan 31.

Department of Basic Medical Sciences, Neuroscience and Organs of Sense, School of Medicine, AOU Policlinico Consorziale, Università di Bari "Aldo Moro", Bari, Italy.

Background: Ceramic-on-ceramic (CoC) bearings due to their mechanical properties can be used in primary total hip arthroplasty (THA) especially in young patients requiring a long-lasting implant. The goal of this study is to analyze the results of a series of 200 consecutive CoC THAs in patients aged 50 years or less at the time of surgery.

Methods: A retrospective study was conducted on the first 200 consecutive CoC arthroplasties performed using the direct lateral approach on 105 females and 81 males (14 bilateral cases) with an average age of 44. Read More

J Biomech 2019 Feb 12. Epub 2019 Feb 12.

Department of Kinesiology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.

Non-contact anterior cruciate ligament (ACL) injuries account for 70% of all ACL injuries, and can lead to missed time from activity for athletes and a predisposition for knee osteoarthritis. Prior research has shown that athletes who land in a stiff manner, with larger internal knee adduction and extension moments, are at greater risk for an ACL injury. A three-dimensional accelerometer placed at the tibial tuberosity may prove to be a low-cost means of assessing these risk factors. Read More

Trials 2019 Feb 18;20(1):135. Epub 2019 Feb 18.

Department of Physical Therapy, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000 - Campus Universitário, Lagoa Nova, Natal, Rio Grande do Norte, 59072-970, Brazil.

Background: Knee osteoarthritis (OA) is characterized by chronic pain, physical dysfunction, and reduced quality of life. Low-load resistance exercises with blood flow restriction (BFR) have presented results similar to those of high-intensity resistance exercise (HIRE) without BFR provided that the exercise volume in both is paired. However, it is unclear whether BFR exercise with reduced load and volume generates clinical improvements similar to those of HIRE. Read More

Bioorg Med Chem 2019 Feb 2. Epub 2019 Feb 2.

Univ. Lyon, Univ. Claude Bernard Lyon 1, CNRS UMR 5246, ICBMS, F-69622 Lyon, France. Electronic address:

Selective proteinase inhibitors have demonstrated utility in the investigation of cartilage degeneration mechanisms and may have clinical use in the management of osteoarthritis. The cysteine protease cathepsin K (CatK) is an attractive target for arthritis therapy. Here we report the synthesis of two cathepsin K inhibitors (CKIs): racemic azanitrile derivatives CKI-E and CKI-F, which have better inhibition properties on CatK than the commercial inhibitor odanacatib (ODN). Read More

J Arthroplasty 2019 Jan 24. Epub 2019 Jan 24.

Department of Orthopaedics, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.

Background: The incidence of revision total knee arthroplasty (TKA) is projected to increase 6-fold worldwide by 2030. As the number of younger, physically active revision TKA patients increases in future, understanding factors influencing postoperative function will be increasingly important to help counsel patients. The primary aim of this study was to examine factors influencing return to physical activity following revision TKA. Read More

Knee 2019 Feb 13. Epub 2019 Feb 13.

School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH, USA; Sports Medicine Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Division of Physical Therapy, The Ohio State University, Columbus, OH, USA. Electronic address:

Purpose: The purpose of this study was to investigate how patient-reported knee function changed over a two-year period in young athletes after anterior cruciate ligament reconstruction (ACLR) and return-to-sport (RTS), and to determine the impact of clinical measures, after controlling for demographic and surgical covariates.

Methods: At the time of RTS after primary, unilateral ACLR, the following data were collected in 67 young athletes: Quadriceps (QF), hamstring (HS), and hip abduction (HA) strength; knee range-of-motion, effusion, and anterior laxity; and patient-reported function using the Knee injury and Osteoarthritis Outcome Score (KOOS). At two years post-RTS, patient-reported function was reevaluated using the KOOS. Read More

J Orthop Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Orthopedic Surgery and Sports Traumatology, Odense University Hospital, J. B. Winsløvsvej 4, Odense C, 5000, Denmark. Electronic address:

Background: Bone fractures are a common cause of hospital admission. Currently, treatment consists of conservative regimens or operation. However, regenerative medicine introduces a possible new addition to established treatments. Read More

J Shoulder Elbow Surg 2019 Mar;28(3):407-414

Center for Shoulder, Elbow, and Sports Medicine, Department of Orthopedic Surgery, Columbia University, New York, NY, USA.

Background: There is no current consensus on subscapularis mobilization during total shoulder arthroplasty. The purpose of this prospective, randomized controlled trial was to compare functional and radiographic outcomes of the more traditional subscapularis tenotomy (ST) versus lesser tuberosity osteotomy (LTO).

Methods: This study enrolled 60 shoulders in 59 patients with primary osteoarthritis. Read More

ANZ J Surg 2019 Feb 15. Epub 2019 Feb 15.

South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.

Background: Total knee replacement (TKR) has been shown to perform differently in patients with rheumatoid arthritis (RA) when compared to osteoarthritis (OA). In this study, we compare the survivorship between these two groups and examine patient and prosthesis factors that impact the revision rate.

Methods: All RA and OA patients undergoing TKR in Australia from 1 September 1999 to 31 December 2016 were included. Read More

Reg Anesth Pain Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Anesthesiology, Rush University Medical Center, Chicago, Illinois, USA

Background: Approximately 15% of patients report persistent knee pain despite surgical success following total knee arthroplasty (TKA). The purpose of this study was to determine the association of acute-postsurgical pain (APSP) with chronic postsurgical pain (CPSP) 6 months after TKA controlling for patient, surgical and psychological confounding factors.

Methods: Adult patients with osteoarthritis undergoing primary elective tricompartmental TKA, with the operated knee the primary source of preoperative pain, were studied between March 2011 and February 2017. Read More

J Knee Surg 2019 Feb 15. Epub 2019 Feb 15.

Department of Orthopedics, Duke University School of Medicine, Durham, North Carolina.

The aim of this study was to assess (1) temporal trends, (2) primary indication, (3) patient-level demographics (age, race, gender, health status, and median income quartile), and (4) region and hospital type for all patients receiving primary total knee arthroplasty (TKA) between 2009 and the third quarter of 2015. The National Inpatient Sample Database (NIS) was used to identify all patients who underwent a TKA between 2009 and the third quarter of 2015. Regression analysis was utilized to assess trends. Read More

Acta Orthop 2019 Feb 14:1-15. Epub 2019 Feb 14.

a Department of Orthopaedics, Institute of Clinical Sciences, The Sahlgrenska Academy , University of Gothenburg , Gothenburg , Sweden.

Background and purpose - Most earlier publications investigating whether annual surgeon volume is associated with lower levels of adverse events (AE), reoperations, and mortality are based on patient cohorts from North America. There is also a lack of adjustment for important confounders in these studies. Therefore, we investigated whether higher annual surgeon volume is associated with a lower risk of adverse events and mortality within 90 days following primary total hip arthroplasty (THA). Read More

Am J Sports Med 2019 Feb 13:363546518824600. Epub 2019 Feb 13.

Cartilage Repair Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Background:: Treating bipolar chondral lesions in the patellofemoral (PF) compartment is a challenging problem. There are few reports available on the treatment of bipolar chondral lesions in the PF compartment.

Purpose:: To evaluate the clinical outcomes and graft survivorship after autologous chondrocyte implantation (ACI) for the treatment of bipolar chondral lesions in the PF compartment. Read More

Cartilage 2019 Feb 13:1947603519828432. Epub 2019 Feb 13.

1 Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

Objective: Both, knee joint distraction (KJD) and high tibial osteotomy (HTO) are joint-preserving surgeries that postpone total knee arthroplasty (TKA) in younger osteoarthritis (OA) patients. Here we evaluate the 2-year follow-up of KJD versus TKA and KJD versus HTO in 2 noninferiority studies.

Design: Knee OA patients indicated for TKA were randomized to KJD ( n = 20; KJD) or TKA ( n = 40). Read More

J Arthroplasty 2019 Jan 23. Epub 2019 Jan 23.

Endogap, Joint Replacement Institute, Garmisch-Partenkirchen Medical Center, Garmisch-Partenkirchen, Germany.

Background: Developmental hip dysplasia is the most common cause of secondary hip osteoarthritis. Due to severe acetabular bone deficiency, cup positioning in total hip arthroplasty (THA) of dysplastic hips remains a surgical challenge. The aim was to analyze the functional outcome of far proximal cup positions in primary THA. Read More

Hip Int 2018 Nov;28(2_suppl):28-34

1 Joint Replacement Division, Department of Orthopedic Surgery and Trauma, ASST Niguarda Hospital, Milan, Italy.

Introduction:: This prospective study aims to evaluate the mid-term clinical and radiological performance of a new short, neck-preserving femoral stem in total hip arthroplasty (THA).

Patients And Methods:: 178 consecutive patients (190 hips) underwent THA from November 2008 to July 2016. Mean follow-up is 62. Read More

Hip Int 2018 Nov;28(2_suppl):21-27

Department of Orthopaedics, Università Cattolica del Sacro Cuore-Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Introduction:: The aim of this retrospective case-control study is to evaluate clinical and radiographic results of short stems compared with traditional hip prostheses.

Methods:: 46 short stems (SS) and 50 traditional stems (TS) were selected. All the stems were implanted by the same surgeon using posterior approach because of primary osteoarthritis, post-traumatic osteoarthritis and avascular necrosis. Read More

Hip Int 2018 Nov;28(2_suppl):15-20

1 U.O. Complex II Division, Gaetano Pini Orthopaedic Institute, Milan, Italy.

Introduction:: Total hip arthroplasty (THA) is 1 of the most common procedures in orthopaedic surgery. Different options and implants are currently available. Uncemented hip cups need primary stability for bone ingrowth, the use of screws is required when the desired stability is not achieved. Read More

Am J Sports Med 2019 Feb 12:363546518825257. Epub 2019 Feb 12.

Department of Orthopaedic Surgery, Kyung Hee University Hospital, Seoul, Republic of Korea.

Background:: Biomechanical studies have shown that double-bundle (DB) posterior cruciate ligament reconstruction (PCLR) is better than single-bundle (SB) PCLR in restoring normal biomechanical function and stability. However, most clinical studies report no differences between the technical methods, and there is yet no long-term clinical comparative study.

Hypothesis:: DB PCLR would show superior results and survivorship outcomes to those of SB PCLR in long-term follow-up. Read More

BMC Musculoskelet Disord 2019 Feb 11;20(1):70. Epub 2019 Feb 11.

Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, School of Immunity, University of Birmingham, Birmingham, UK.

Background: Preclinical osteoarthritis models where damage occurs spontaneously may better reflect the initiation and development of human osteoarthritis. The aim was to assess the commercial pig as a model of spontaneous osteoarthritis development by examining pain-associated behaviour, joint cartilage integrity, as well as the use of porcine cartilage explants and isolated chondrocytes and osteoblasts for ex vivo and in vitro studies.

Methods: Female pigs (Large white x Landrace x Duroc) were examined at different ages from 6 weeks to 3-4 years old. Read More

Acta Orthop 2019 Feb 11:1-13. Epub 2019 Feb 11.

a The Swedish Hip Arthroplasty Register , Gothenburg.

Background and purpose - In total hip replacements, stem design may affect the occurrence of periprosthetic femoral fracture. We studied risk factors for fractures around and distal to the 2 most used cemented femoral stems in Sweden. Patients and methods - This is a register study including all standard primary Lubinus SPII and Exeter Polished stems operated in Sweden between 2001 and 2009. Read More

Acta Orthop 2019 Feb 11:1-8. Epub 2019 Feb 11.

b Swedish Hip Arthroplasty Register , Gothenburg , Sweden.

Background and purpose - International comparisons of total hip arthroplasty (THA) practices and outcomes provide an opportunity to enhance the quality of care worldwide. We compared THA patients, implants, techniques, and survivorship in Sweden, Australia, and the United States. Patients and methods - Primary THAs due to osteoarthritis were identified using Swedish (n = 159,695), Australian (n = 279,693), and US registries (n = 69,641) (2003-2015). Read More

Knee Surg Sports Traumatol Arthrosc 2019 Feb 9. Epub 2019 Feb 9.

Department of Orthopaedic Surgery, National University Hospital, National University Health System, Singapore, Level 11 NUH Tower Block, 1E Kent Ridge Rd, Singapore, 119228, Singapore.

Purpose: The purpose of this prospective, randomized, double-blinded, placebo-controlled study was to determine if pregabalin, when given perioperatively in addition to patient-controlled analgesia morphine, paracetamol and etoricoxib, is effective in reducing morphine requirements and moderating pain scores after primary total knee arthroplasty. We hypothesize that there would be no difference in postoperative opioid requirements, postoperative pain scores, and functional scores with the use of perioperative pregabalin.

Methods: Eighty-seven patients who underwent primary total knee arthroplasty were randomised and allocated to two groups. Read More

Drugs Aging 2019 Feb 9. Epub 2019 Feb 9.

Research and Development Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, Barcelona, Spain.

Introduction: Angiotensin-converting enzyme inhibitors (ACEI) may have several pleiotropic effects, but the literature regarding a possible relationship between ACEI use and frailty is limited. We investigated whether ACEI use is associated with lower risk of frailty in a cohort of North American individuals.

Methods: Data from the Osteoarthritis Initiative, a cohort study with 8 years of follow-up including community-dwelling adults with knee osteoarthritis or at high risk for this condition, were analyzed. Read More

BMC Musculoskelet Disord 2019 Feb 8;20(1):63. Epub 2019 Feb 8.

Department of Orthopaedic Surgery, Gyeongsang National University Hospital, Jinju, South Korea.

Background: Comparative studies of total hip arthroplasty using the direct anterior approach (DAA) compared with the anterolateral approach (ALA) by gait analysis compared the results of the two groups, the damage to the abductor muscle, with objective and detailed kinematic as well as kinetic data of actual gait. The purpose of this systematic review was to analyze the differences in gait such as time-dependent parameters, kinetics, and kinematics after THA using the DAA compared with ALA.

Methods: PubMed Central, OVID Medline, Cochrane Collaboration Library, Web of Science, EMBASE and AHRQ carried out a comprehensive search for all relevant randomized controlled trials and comparative studies, up to December 2018. Read More

J Knee Surg 2019 Feb 8. Epub 2019 Feb 8.

Department of Orthopaedic Surgery, Lenox Hill Hospital, New York, New York.

The purpose of this meta-analysis was to assess the evidence supporting the use of cementless versus cemented total knee arthroplasties (TKAs). Specifically, we evaluated (1) all-cause survivorship, (2) aseptic survivorship, and (3) functional outcomes (Knee Society Scores [KSS], Oxford Knee Scores, Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC] scores, and ranges of motion [ROMs]). A literature search was performed for studies that evaluated cementless versus cemented TKAs published between 2000 and 2017. Read More

Int J Biometeorol 2019 Feb 7. Epub 2019 Feb 7.

Department of Environmental Health, Institute of Public Health Medicine, Medical School, University of Pécs, 12 Szigeti str., Pécs, 7624, Hungary.

The therapeutic effects of mineral waters have been attributed to the inorganic components alone; however, biologically active organic components are also present. We aimed to investigate whether the healing effect of Szigetvár thermal mineral water could relate to the organic matter in patients suffering from osteoarthritis of the hips and the knees. XAD macroreticular resins were used to prepare the organic fraction. Read More

BMJ 2019 Feb 7;364:l185. Epub 2019 Feb 7.

Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS), University of Oxford, Botnar Research Centre, Oxford OX3 7LD, UK.

Objective: To compare arthroscopic hip surgery with physiotherapy and activity modification for improving patient reported outcome measures in patients with symptomatic femoroacetabular impingement (FAI).

Design: Two group parallel, assessor blinded, pragmatic randomised controlled trial.

Setting: Secondary and tertiary care centres across seven NHS England sites. Read More

J Arthroplasty 2019 Jan 17. Epub 2019 Jan 17.

Department of Orthopedic Surgery, Veterans Health Service Medical Center, Seoul, South Korea.

Background: This study compared the rates of plain radiographs and computed tomography (CT) for detecting lateral hinge fractures and to evaluate factors affecting lateral hinge fractures in patients following medial opening-wedge high tibial osteotomy (MOWHTO).

Methods: This prospective study included 59 patients (65 knees) undergoing MOWHTO for primary medial compartment osteoarthritis with a 2-year follow-up between 2013 and 2016. Clinical and radiographic evaluations were performed using Knee Society Score and Western Ontario and McMaster Universities Arthritis Index, and we calculated the hip-knee-ankle angle, weight-bearing line ratio, lateral distal femoral angle, medial proximal tibial angle, posterior tibial slope, osteotomy gap height, and osteotomy gap filling rate. Read More

Arthroscopy 2019 Feb 4. Epub 2019 Feb 4.

Steadman Clinic, Vail, Colorado, U.S.A.; Steadman Philippon Research Institute, Vail, Colorado, U.S.A.. Electronic address:

Purpose: To compare the clinical outcomes between 2 groups of patients who underwent arthroscopic hip capsular reconstruction with the same surgical technique with an iliotibial band (ITB) allograft versus dermal allograft tissue.

Methods: From March 2013 to October 2015, patients who were 18 years of age or older and who underwent revision arthroscopic hip surgery with capsular reconstruction by the senior author were identified. Patients who were younger than 18 years old, had a lateral center-edge angle <20° or Tonnis osteoarthritis grade 2 or 3, or refused to participate were excluded. Read More

J Bone Joint Surg Am 2019 Feb;101(3):250-256

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois.

Background: Prior work suggests that computer-assisted navigation improves acetabular component position during primary total hip arthroplasty (THA). However, it is not known whether this translates to improvements in clinical outcomes. The purpose of this study was to test for associations between navigation use and the risk of dislocation, aseptic revision of the acetabular component, aseptic revision of the femoral component, aseptic revision of either component, and acute periprosthetic joint infection (PJI). Read More

J Bone Joint Surg Am 2019 Feb;101(3):218-227

Department of Epidemiology and Biostatistics, Temple University, Philadelphia, Pennsylvania.

Background: Pain catastrophizing has been identified as a prognostic indicator of poor outcome following knee arthroplasty. Interventions to address pain catastrophizing, to our knowledge, have not been tested in patients undergoing knee arthroplasty. The purpose of this study was to determine whether pain coping skills training in persons with moderate to high pain catastrophizing undergoing knee arthroplasty improves outcomes 12 months postoperatively compared with usual care or arthritis education. Read More

Methods Mol Biol 2019 ;1914:391-407

Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.

Bone pain is a prevalent issue in society today and also is one of the hardest types of pain to control. Pain originating in the bone can be caused by many different entities including metastatic and primary neoplasm, fracture, osteoarthritis as well as numerous other metabolic disorders. In this chapter we describe the methods and protocols that currently are accepted and validated for the study of bone pain in models of metastatic cancer, bicortical fracture and osteoarthritis. Read More

Front Pharmacol 2019 23;10:15. Epub 2019 Jan 23.

Department of Dental Research, School of Stomatology, Kunming Medical University, Kunming, China.

Temporomandibular joint osteoarthritis (TMJ-OA), mainly exhibit extracellular matrix loss and condylar cartilage degradation, is the most common chronic and degenerative maxillofacial osteoarthritis; however, no efficient therapy for TMJ-OA exists due to the poor understanding of its pathological progression. MicroRNA (miR)-140-5p is a novel non-coding microRNAs (miRNAs) that expressed in osteoarthritis specifically. To investigate the molecular mechanisms of miR-140-5p in TMJ-OA, primary mandibular condylar chondrocytes (MCCs) from C57BL/6N mice were treated with interleukins (IL)-1β or transfected with miR-140-5p mimics or inhibitors, respectively. Read More

J Knee Surg 2019 Feb 6. Epub 2019 Feb 6.

Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio.

Newer generation cementless total knee arthroplasty (TKA) implants continue to develop with demonstrated clinical success in multiple recent reports. The purpose of this study was to investigate (1) survivorship, (2) complications, and (3) clinical outcomes of a newer generation cementless and highly porous titanium-coated base plate manufactured using three-dimensional (3D) printing technology. We reviewed a single-surgeon, longitudinally maintained database of patients who underwent primary TKA using cementless, highly porous titanium-coated base plate implants from July 1, 2013 to December 31, 2016. Read More

J Knee Surg 2019 Feb 6. Epub 2019 Feb 6.

Department of Orthopaedic Surgery, Peking University People's Hospital, Beijing, China.

Total knee arthroplasty (TKA) for patients with valgus deformity (> 10 degrees) is technically challenging and has produced variable clinical results in terms of deformity correction, instability, and overall outcomes. The lateral parapatellar approach (LPA) is an alternative to the traditional medial parapatellar approach with potential advantages of direct access for release of tight lateral ligamentous structures with preservation of the medial structures, optimized patellar tracking, preserved medial blood supply to the patella, and less use of constrained implants. We present a case series of a single institution's experience with use of a modified LPA using a Z-capsuloplasty for 35 primary TKA cases in 30 patients with osteoarthritis and Ranawat's type-II fixed valgus deformity with attenuation of medial soft tissues. Read More

Clin Drug Investig 2019 Feb 6. Epub 2019 Feb 6.

Department of Rheumatology and Immunology, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, People's Republic of China.

Background And Objective: Loxoprofen (LOX) is a nonsteroidal anti-inflammatory drug (NSAID). Although oral administration of LOX has been widely prescribed, clinical guidelines for osteoarthritis generally recommend topical rather than oral NSAIDs in specific patients. However, there is limited information on the effects of loxoprofen sodium oral (LOX-O) versus loxoprofen sodium hydrogel transdermal patch (LOX-T) in myalgia patients. Read More

Rev Med Chil 2018 Sep;146(9):987-993

Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad de Granada, España.

Background: Obesity is associated with pain, reduction of function and quality of life in patients with osteoarthritis (OA).

Aim: To describe the clinical profile of women with knee OA according to their body mass index (BMI).

Material And Methods: Observational study in 308 women with knee OA. Read More

Med Sci Sports Exerc 2019 Feb 4. Epub 2019 Feb 4.

Nike Sport Research Lab, Beaverton, OR.

Purpose: Elevated tibiofemoral joint (TFJ) contact forces have been linked to the development and progression of knee osteoarthritis. The primary objective of this study was to determine the association between peak TFJ shear and compression forces during running at different self-selected step frequencies (SF) in female recreational runners.

Methods: Fifty-five healthy female recreational runners ran at 2. Read More

Discov Med 2019 01;27(146):17-26

Department of Orthopedic Surgery and Sports Medicine Center, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, China.

Objective: The current study was carried out to investigate the serum and synovial fluid (SF) alpha-melanocyte-stimulating hormone (α-MSH) levels in correlation with disease severity in primary knee osteoarthritis (OA).

Methods: This study comprised of 105 primary knee OA patients and 98 healthy controls. The radiographic severity was verified according to the Kellgren-Lawrence radiographic grading criteria. Read More

Knee Surg Sports Traumatol Arthrosc 2019 Feb 5. Epub 2019 Feb 5.

Division of Health Sciences, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.

Purpose: Osteochondral allografts (OCA) consist of a layer of hyaline cartilage and a layer of underlying bone. They are used to repair combined defects of articular cartilage and bone. Such defects often occur in people far too young to have knee arthroplasty, for whom the main alternative to OCA is conservative symptomatic care, which will not prevent development of osteoarthritis. Read More