81,019 results match your criteria Osteoarthritis


The Who, What, and Where of Primary TKAs: An Analysis of HCUP Data from 2009 to 2015.

J Knee Surg 2019 Feb 15. Epub 2019 Feb 15.

Department of Orthopedics, Duke University School of Medicine, Durham, North Carolina.

The aim of this study was to assess (1) temporal trends, (2) primary indication, (3) patient-level demographics (age, race, gender, health status, and median income quartile), and (4) region and hospital type for all patients receiving primary total knee arthroplasty (TKA) between 2009 and the third quarter of 2015. The National Inpatient Sample Database (NIS) was used to identify all patients who underwent a TKA between 2009 and the third quarter of 2015. Regression analysis was utilized to assess trends. Read More

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http://dx.doi.org/10.1055/s-0039-1677857DOI Listing
February 2019

IgMCD27 B cells possessed regulatory function and represented the main source of B cell-derived IL-10 in the synovial fluid of osteoarthritis patients.

Hum Immunol 2019 Feb 12. Epub 2019 Feb 12.

Department of Orthopedics, Shandong Qianfoshan Hospital, Shandong University, Jinan, Shandong, China. Electronic address:

Synovial inflammation is observed in patients with osteoathritis (OA) and likely contributed to its exacerbation. Regulatory B (Breg) cells are shown to suppress inflammation in various diseases, including rheumatoid arthritis (RA). To examine whether Breg cells also participated in OA, we examined the synovial fluid from OA patients, and compared with that in RA patients. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.02.007DOI Listing
February 2019

Stifle joint osteoarthritis at the time of diagnosis of cranial cruciate ligament injury is higher in Boxers and in dogs weighing more than 35 kilograms.

Vet Radiol Ultrasound 2019 Feb 15. Epub 2019 Feb 15.

Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27607.

Osteoarthritis is a ubiquitous disease in dogs. The purpose of this retrospective study was to characterize the severity and distribution of osteoarthritis (OA) within the joint and to identify differences among dog breeds in the severity of OA in the cranial cruciate ligament (CCL)-deficient stifle joint. Radiographs of 240 stifles from 51 Boxers, 66 German Shepherds, 100 Labrador Retrievers, and 23 Siberian Huskies with confirmed CCL rupture were included. Read More

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http://dx.doi.org/10.1111/vru.12718DOI Listing
February 2019

Novel Herbal Topical Patch containing Curcumin and Arnica Montana for the Treatment of Osteoarthritis.

Curr Rheumatol Rev 2019 Feb 14. Epub 2019 Feb 14.

Kota college of pharmacy, Kota, 325003, Rajasthan. India.

Background: Osteoarthritis (OA) ranks fifth among all forms of disability affecting 10% of the world population. Current treatments available are associated with multiple side effects and do not slow down the progression of disease. Moreover no such effective treatment is available till date in various systems of medicine to treat osteoarthritis. Read More

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http://dx.doi.org/10.2174/1573397115666190214164407DOI Listing
February 2019

Bone Density and Texture from Minimally Post-Processed Knee Radiographs in Subjects with Knee Osteoarthritis.

Ann Biomed Eng 2019 Feb 14. Epub 2019 Feb 14.

Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland.

Plain radiography is the most common modality to assess the stage of osteoarthritis. Our aims were to assess the relationship of radiography-based bone density and texture between radiographs with minimal and clinical post-processing, and to compare the differences in bone characteristics between controls and subjects with knee osteoarthritis or medial tibial bone marrow lesions (BMLs). Tibial bone density and texture was evaluated from radiographs with both minimal and clinical post-processing in 109 subjects with and without osteoarthritis. Read More

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http://link.springer.com/10.1007/s10439-019-02227-y
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http://dx.doi.org/10.1007/s10439-019-02227-yDOI Listing
February 2019
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Open posterior capsular release with an osteotome in total knee arthroplasty does not place important neurovascular structures at risk.

Knee Surg Sports Traumatol Arthrosc 2019 Feb 14. Epub 2019 Feb 14.

University of Alabama at Birmingham, 1201 11th Avenue South, Suite 200, Birmingham, AL, 35205, USA.

Purpose: Posterior capsular contracture is a potential consequence of osteoarthritis, post-traumatic arthritis, and surgical procedures of the knee. Many patients who undergo TKA will be found to have some degree of flexion contracture intraoperatively, which necessitates posterior capsular release. There is no information in the literature about the safety of posterior capsular release done during TKA. Read More

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http://dx.doi.org/10.1007/s00167-019-05399-1DOI Listing
February 2019

Head to Knee: Cranial Neural Crest-Derived Cells as Promising Candidates for Human Cartilage Repair.

Stem Cells Int 2019 15;2019:9310318. Epub 2019 Jan 15.

Laboratory of Molecular Oral Pathophysiology, INSERM UMRS 1138, Cordeliers Research Center, Universites of Paris-Descartes, Pierre and Marie Curie and Paris-Diderot, 15 rue de l'école de médecine, Paris, France.

A large array of therapeutic procedures is available to treat cartilage disorders caused by trauma or inflammatory disease. Most are invasive and may result in treatment failure or development of osteoarthritis due to extensive cartilage damage from repeated surgery. Despite encouraging results of early cell therapy trials that used chondrocytes collected during arthroscopic surgery, these approaches have serious disadvantages, including morbidity associated with cell harvesting and low predictive clinical outcomes. Read More

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http://dx.doi.org/10.1155/2019/9310318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350557PMC
January 2019

Association between ACE gene I/D polymorphism and knee osteoarthritis in a Chinese population.

Biosci Rep 2019 Feb 14. Epub 2019 Feb 14.

Zhejiang Provincial People's Hospital, Hangzhou, China

Osteoarthritis (OA) is a degenerative joint disease characterized by joint destruction with cartilage loss and occasional gross derangement of joint integrity. In recent years, several studies have reported the association between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and knee osteoarthritis (OA). However, the results were conflicting. Read More

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http://dx.doi.org/10.1042/BSR20181713DOI Listing
February 2019

Unusual presentation of acute pancreatitis following high tibial osteotomy.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Department of General Surgery, Royal Albert Edward Infirmary, Wigan, UK.

We report a case of a 55-year-old man taxi driver admitted electively for high tibial osteotomy for relief of bilateral medial compartment osteoarthritis. He was obese and an ex-smoker but medical history was otherwise unremarkable. Day 1 postoperatively the patient started to suffer vomiting episodes and the abdomen was distended. Read More

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http://dx.doi.org/10.1136/bcr-2018-227438DOI Listing
February 2019

Operative Versus Conservative Treatment of Anterior Cruciate Ligament Rupture.

Dtsch Arztebl Int 2018 Dec;115(51-52):855-862

Department of Trauma, Hand and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf; Department of General Orthopedics and Center for Endoprosthetics, Schön Klinik Hamburg Eilbek; Department of Sports Orthopedics, University Hospital rechts der Isar, Technical University of Munich (TUM); Department of Orthopedics and Trauma Surgery, Martin-Luther-Hospital, Berlin; Department of Trauma and Reconstructive Surgery With Division of Knee and Shoulder Surgery, Sports Traumatology, Asklepios Klinik St. Georg, Hamburg.

Background: Anterior cruciate ligament (ACL) rupture is a serious injury in patients who are typically young and athletically active, with potential long-term complica- tions including functional limitation, posttraumatic osteoarthritis of the knee, and impaired quality of life. ACL reconstruction is now considered the gold standard of treatment for regaining stability and improving knee function. Conservative treatment is an alternative. Read More

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http://dx.doi.org/10.3238/arztebl.2018.0855DOI Listing
December 2018

Effect of Vitamin D supplementation on synovial tissue volume and subchondral bone marrow lesion volume in symptomatic knee osteoarthritis.

BMC Musculoskelet Disord 2019 Feb 14;20(1):76. Epub 2019 Feb 14.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Background: Data from a recent clinical trial of vitamin D therapy in knee OA suggests that, compared to placebo, vitamin D therapy may be associated with a reduction in effusion-synovitis. Our aim was, using contrast-enhanced (CE) magnetic resonance imaging (MRI), to examine the effect of vitamin D therapy on synovial tissue volume (STV) and also subchondral bone marrow lesion (BML) volume in men and women with symptomatic knee OA.

Methods: Data was acquired from participants who took part in a randomised placebo-controlled trial (UK VIDEO) investigating the effect of vitamin D therapy (800 IU cholecalciferol daily) on radiographic joint space narrowing. Read More

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https://bmcmusculoskeletdisord.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12891-019-2424-4DOI Listing
February 2019

VEGF-A is associated with early degenerative changes in cartilage and subchondral bone.

Growth Factors 2019 Feb 15:1-11. Epub 2019 Feb 15.

a University of Ljubljana, Faculty of Pharmacy , Department of Clinical Biochemistry.

Paired cartilage and subchondral bone of subjects with no clinical history of joint disorders were analyzed to determine whether antioxidant enzymes, inflammatory cytokines and growth factors can be linked to a pre-osteoarthritis. Tissue explants were phenotyped according to Osteoarthritis Research Society International grading and micro-computed tomography, and also screened for the expression of several markers using quantitative polymerase chain reaction. The expression of these same genes was measured in SW1353 cells treated with hydrogen peroxide, to gain insight into the pathways involved with oxidative stress responses. Read More

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http://dx.doi.org/10.1080/08977194.2019.1570926DOI Listing
February 2019

Morphine, but not methadone, inhibits microsomal prostaglandin E synthase-1 and prostaglandin-endoperoxide synthase 2 in lipopolysaccharide-stimulated horse synoviocytes.

Biochimie 2019 Feb 11. Epub 2019 Feb 11.

Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil. Electronic address:

Osteoarthritis (OA) is one of the main locomotor disorders in horses. Although nonsteroidal anti-inflammatory drugs are the first-line treatment for OA, opioids could also be used. In previous studies, opioids showed promising anti-inflammatory and analgesic effects. Read More

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http://dx.doi.org/10.1016/j.biochi.2019.02.004DOI Listing
February 2019

Navigation-Assisted Total Knee Arthroplasty for a Valgus Knee Improves Limb and Femoral Component Alignment.

Orthopedics 2019 Feb 14:1-7. Epub 2019 Feb 14.

The purpose of this study was to evaluate the influence of navigation-assisted surgery on radiographic and clinical outcomes after total knee arthroplasty (TKA) for a valgus knee. The authors identified all patients who underwent TKA for a valgus knee between January 2005 and December 2015. Among 83 conventional TKA cases and 55 navigation-assisted TKA cases, propensity score matching was performed for age, sex, body mass index, and preoperative lower limb mechanical axis. Read More

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http://dx.doi.org/10.3928/01477447-20190211-02DOI Listing
February 2019

The use of ultrasound-guided platelet-rich plasma injections in the treatment of hip osteoarthritis: a systematic review of the literature.

J Ultrason 2018 ;18(75):332-337

Northumbria Healthcare NHS Foundation Trust , North Shields , United Kingdom.

This review aims to determine whether ultrasound-guided platelet-rich plasma injection has any role in improving clinical outcomes in patients with hip osteoarthritis. A search of the National Institute for Health and Care Excellence database using the Healthcare Databases Advanced Search tool was conducted. The PubMed database was also utilised to search the Medical Literature Analysis and Retrieval System Online, Excerpta Medica database, Cumulative Index of Nursing and Allied Health and Allied and Complimentary Medicine databases. Read More

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http://jultrason.pl/index.php/issues/volume-18-no-75/the-use
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http://dx.doi.org/10.15557/JoU.2018.0048DOI Listing
January 2018
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Efficacy of Duohuojisheng decoction monotherapy for the treatment of knee osteoarthritis: A protocol of a systematic review of randomized controlled trials.

Medicine (Baltimore) 2019 Feb;98(7):e14510

First Ward of Orthopedics Department, Inner Mongolia Xilin Gol League Hospital, Xilinhot, China.

Background: This systematic review investigates the efficacy and safety of Duohuojisheng decoction (DHJSD) monotherapy for the treatment of patients with knee osteoarthritis (KOA).

Methods: We searched relevant studies on DHJSD monotherapy for KOA from the databases of CENTRAL, EMBASE, MEDLINE, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, VIP Information, and Wanfang Data from the inception to January 1, 2019. Two researchers independently selected studies, collected data, and assessed the methodology quality by using Cochrane risk of bias tool. Read More

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http://dx.doi.org/10.1097/MD.0000000000014510DOI Listing
February 2019

The Reliability of Commonly Used Radiographic Parameters in the Evaluation of the Pre-Arthritic Hip: A Systematic Review.

JBJS Rev 2019 Feb 12. Epub 2019 Feb 12.

Peachtree Orthopedics, Atlanta, Georgia.

Background: Radiographs play a central role in the evaluation of the extent of arthritic change and the quantification of morphological parameters characteristic of femoroacetabular impingement (FAI) and/or dysplasia. Reporting of these parameters is widespread in the literature, occasionally as an instrument for data pooling in collaborative research endeavors. Yet, the metrological properties of commonly used radiographic descriptors of acetabular and femoral architecture relevant to the field of hip preservation have not been reviewed systematically. Read More

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http://dx.doi.org/10.2106/JBJS.RVW.18.00048DOI Listing
February 2019

Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial.

Regen Med 2019 Feb 14. Epub 2019 Feb 14.

Magellan Stem Cells, VIC, Australia.

Aim: To evaluate the efficacy of autologous adipose-derived mesenchymal stem cell (ADMSC) therapy on pain, function and disease modification in knee osteoarthritis.

Methods: 30 participants with symptomatic knee osteoarthritis were randomized into three groups. Two treatment groups received intra-articular ADMSC therapy consisting of either a single injection (100 × 10 ADMSCs) or two injections (100 × 10 ADMSCs at baseline and 6 months). Read More

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http://dx.doi.org/10.2217/rme-2018-0161DOI Listing
February 2019

High annual surgeon volume reduces the risk of adverse events following primary total hip arthroplasty: a registry-based study of 12,100 cases in Western Sweden.

Acta Orthop 2019 Feb 14:1-15. Epub 2019 Feb 14.

a Department of Orthopaedics, Institute of Clinical Sciences, The Sahlgrenska Academy , University of Gothenburg , Gothenburg , Sweden.

Background and purpose - Most earlier publications investigating whether annual surgeon volume is associated with lower levels of adverse events (AE), reoperations, and mortality are based on patient cohorts from North America. There is also a lack of adjustment for important confounders in these studies. Therefore, we investigated whether higher annual surgeon volume is associated with a lower risk of adverse events and mortality within 90 days following primary total hip arthroplasty (THA). Read More

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http://dx.doi.org/10.1080/17453674.2018.1554418DOI Listing
February 2019

Men and women's occupational activities and the risk of developing osteoarthritis of the knee, hip or hands: A systematic review and recommendations for future research.

Arthritis Care Res (Hoboken) 2019 Feb 14. Epub 2019 Feb 14.

Occupational Science & Occupational Therapy, University of British Columbia, Vancouver, B.C., Canada.

Objective: To systematically review the evidence for an increased risk of osteoarthritis in the hip, knee, hand, wrist, finger, ankle, foot, shoulder, neck and spine related to men and women's diverse occupational activities and to examine dose response information related to the frequency, intensity, and duration of work exposures and the risk of OA.

Methods: Established guidelines for systematic reviews in occupational health and safety studies were followed. MEDLINE, EMBASE, CINAHL and Cochrane Library were searched from inception to December 2017. Read More

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http://dx.doi.org/10.1002/acr.23855DOI Listing
February 2019

Patient-reported outcomes 1 to 5 years after ACL reconstruction: effect of combined injury, and associations with MRI-defined osteoarthritis features.

Arthritis Care Res (Hoboken) 2019 Feb 14. Epub 2019 Feb 14.

La Trobe Sport & Exercise Medicine Research Centre, School of Allied Health, La Trobe University, Bundoora, Australia.

Objective: Persistent symptoms and poor quality of life (QoL) are common following anterior cruciate ligament reconstruction (ACLR). We aimed to determine the influence of a combined ACL injury (i.e. Read More

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http://dx.doi.org/10.1002/acr.23854DOI Listing
February 2019

Modifiable Determinants of Exercise Use in a Diverse Ethnic Population with Osteoarthritis.

Arthritis Care Res (Hoboken) 2019 Feb 14. Epub 2019 Feb 14.

University of Arizona Arthritis Center, Tucson, AZ.

Objectives: To determine the extent of ethnic differences in using exercise for therapy and Identify relevant modifiable determinants of exercise use among knee/hip osteoarthritis (OA) patients METHODS: Knee/hip OA study participants were identified. Surveys were administered to collect patient socio-demographics, clinical information, and beliefs and attitudes about providers and treatments. Final multivariable logistic regression models were created using a fully conditional method. Read More

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http://dx.doi.org/10.1002/acr.23852DOI Listing
February 2019

Mesenchymal Stem Cell Therapy for Osteoarthritis: The Critical Role of the Cell Secretome.

Front Bioeng Biotechnol 2019 29;7. Epub 2019 Jan 29.

Regenerative Medicine Institute (REMEDI), Biosciences, National University of Ireland Galway, Galway, Ireland.

Osteoarthritis (OA) is an inflammatory condition still lacking effective treatments. Mesenchymal stem/stromal cells (MSCs) have been successfully employed in pre-clinical models aiming to resurface the degenerated cartilage. In early-phase clinical trials, intra-articular (IA) administration of MSCs leads to pain reduction and cartilage protection or healing. Read More

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https://www.frontiersin.org/article/10.3389/fbioe.2019.00009
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http://dx.doi.org/10.3389/fbioe.2019.00009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361779PMC
January 2019
1 Read

Schisandrin A Inhibits the IL-1β-Induced Inflammation and Cartilage Degradation via Suppression of MAPK and NF-κB Signal Pathways in Rat Chondrocytes.

Front Pharmacol 2019 29;10:41. Epub 2019 Jan 29.

Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Osteoarthritis (OA) is a common joint disease in the elderly population. Its development has been reported to be associated with cartilage degradation and inflammatory responses. Schisandrin A, a bioactive lignin in , has shown its anti-inflammatory potential in various inflammation diseases. Read More

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http://dx.doi.org/10.3389/fphar.2019.00041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361757PMC
January 2019

NOD2 signaling pathway is involved in fibronectin fragment-induced pro-catabolic factor expressions in human articular chondrocytes.

BMB Rep 2019 Feb 14. Epub 2019 Feb 14.

Division of Rheumatology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi, 14068, Korea; Institute for Skeletal Aging, Hallym University, Chunchon, 24251, Korea.

The nucleotide-binding and oligomerization domain (NOD) is an innate pattern recognition receptor that recognizes pathogen- and damage-associated molecular patterns. The 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) is a matrix degradation product found in the synovial fluids of patients with osteoarthritis (OA). We investigated whether NOD2 was involved in 29-kDa FN-f-induced pro-catabolic gene expression in human chondrocytes. Read More

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February 2019

The cerebral mechanism of acupuncture for treating knee osteoarthritis: study protocol for a randomized controlled trial.

Trials 2019 Feb 13;20(1):126. Epub 2019 Feb 13.

Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, 37# Shierqiao Road, Chengdu, 610075, Sichuan, China.

Background: Acupuncture is safe and effective for reducing the symptoms of knee osteoarthritis (KOA), but the underlying mechanisms of acupuncture for treating KOA are not fully understood.

Methods/design: In total, 108 participants diagnosed with KOA will be recruited. They will be blinded to group assignment and randomized to either verum acupuncture, sham acupuncture or waiting-list groups with 36 patients in each group. Read More

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https://trialsjournal.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13063-019-3233-7DOI Listing
February 2019
4 Reads

Developing strategic priorities in osteoarthritis research: Proceedings and recommendations arising from the 2017 Australian Osteoarthritis Summit.

BMC Musculoskelet Disord 2019 Feb 13;20(1):74. Epub 2019 Feb 13.

Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Melbourne, Australia.

Background: There is a pressing need to enhance osteoarthritis (OA) research to find ways of alleviating its enormous individual and societal impact due to the high prevalence, associated disability, and extensive costs.

Methods: Potential research priorities and initial rankings were pre-identified via surveys and the 1000Minds process by OA consumers and the research community. The OA Summit was held to decide key research priorities that match the strengths and expertise of the Australian OA research community and align with the needs of consumers. Read More

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http://dx.doi.org/10.1186/s12891-019-2455-xDOI Listing
February 2019

Cross-Shaped Bone Grafting and Locking Plate Fixation for Arthrodesis of the Trapeziometacarpal Joint: Surgical Technique and Early Mobilization.

J Hand Surg Asian Pac Vol 2019 Mar;24(1):55-59

1 Department of Orthopedic Surgery, Yamaguchi University School of Medicine, Yamaguchi, Japan.

Background: The trapeziometacarpal joint is the second most common site of osteoarthritis in the hand and the most frequent one to require surgery. Arthrodesis of the trapeziometacarpal joint is recognized as one of the valuable technique but unfortunately there has been wide variation in the union rate. The purpose of this study was to evaluate a new arthrodesis technique involving a cross-shaped bone graft and locking plate fixation. Read More

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http://dx.doi.org/10.1142/S2424835519500103DOI Listing

Comparison of Five Years Clinical and Radiological Outcomes between Progressive and Non-Progressive Wrist Osteoarthritis after Volar Locking Plate Fixation of Distal Radius Fractures.

J Hand Surg Asian Pac Vol 2019 Mar;24(1):30-35

‡ Department of Hand Surgery, Nara Medical University, Kashihara, Nara, Japan.

Background: This study aimed to identify the effect of the progression of postoperative wrist osteoarthritis on 5 years clinical and radiological outcomes after volar locking plate fixation of distal radius fractures.

Methods: Altogether, 56 patients with distal radius fractures were followed up 5 years after surgery. Clinical assessment was performed using the Mayo modified wrist score, a visual analogue scale of pain, the Japanese version of the Disabilities of the Arm, Shoulder, and Hand score, and Patient-related wrist evaluation. Read More

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http://dx.doi.org/10.1142/S2424835519500061DOI Listing

Developmental Transformation and Reduction of Connective Cavities within the Subchondral Bone.

Int J Mol Sci 2019 Feb 12;20(3). Epub 2019 Feb 12.

Clinic for Trauma Surgery, Orthopaedic Surgery and Plastic Surgery, Universitätsmedizin Göttingen, 37075 Göttingen, Germany.

It is widely accepted that the subchondral bone (SCB) plays a crucial role in the physiopathology of osteoarthritis (OA), although its contribution is still debated. Much of the pre-clinical research on the role of SCB is concentrated on comparative evaluations of healthy vs. early OA or early OA vs. Read More

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http://dx.doi.org/10.3390/ijms20030770DOI Listing
February 2019

IL-10 Could Play a Role in the Interrelation between Diabetes Mellitus and Osteoarthritis.

Int J Mol Sci 2019 Feb 12;20(3). Epub 2019 Feb 12.

Institute of Anatomy, Paracelsus Medical University, Nuremberg and Salzburg, Prof. Ernst Nathan Str. 1, 90419 Nuremberg, Germany.

The association between osteoarthritis (OA), obesity and metabolic syndrome suggests an interrelation between OA and diabetes mellitus (DM). Little is known about the role of anti-inflammatory cytokine interleukin (IL)-10 in the interrelation between OA and DM. Hence, the effects of IL-10 under hyperglycemia (HG) and hyperinsulinemia (HI) in human articular chondrocytes (hAC) and chondrosarcoma cell line Okayama University Medical School (OUMS)-27 were examined. Read More

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http://dx.doi.org/10.3390/ijms20030768DOI Listing
February 2019

Autologous Chondrocyte Implantation for Bipolar Chondral Lesions in the Patellofemoral Compartment: Clinical Outcomes at a Mean 9 Years' Follow-up.

Am J Sports Med 2019 Feb 13:363546518824600. Epub 2019 Feb 13.

Cartilage Repair Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Background:: Treating bipolar chondral lesions in the patellofemoral (PF) compartment is a challenging problem. There are few reports available on the treatment of bipolar chondral lesions in the PF compartment.

Purpose:: To evaluate the clinical outcomes and graft survivorship after autologous chondrocyte implantation (ACI) for the treatment of bipolar chondral lesions in the PF compartment. Read More

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http://dx.doi.org/10.1177/0363546518824600DOI Listing
February 2019

Syphilis with Charcot arthropathy: a case report.

Dermatol Ther 2019 Feb 13:e12862. Epub 2019 Feb 13.

Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.

Syphilis is a chronic systemic infectious disease involving multiple organs. Involvement of skeletal system by syphilis including osteochondritis, osteoarthritis, periostitis and osteitis. Charcot arthropathy is an unusual concomitant disease of syphilis, and the incidence had decreased significantly these decades. Read More

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http://dx.doi.org/10.1111/dth.12862DOI Listing
February 2019

The use of PRP injections in the management of knee osteoarthritis.

Cell Tissue Res 2019 Feb 13. Epub 2019 Feb 13.

Centre for Biological Engineering, Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Epinal Way, Loughborough, Leicestershire, LE11 3TU, UK.

Osteoarthritis (OA) is a degenerative disease involving joint damage, an inadequate healing response and progressive deterioration of the joint architecture that commonly affects the knee and/or hip joints. It is a major world public health problem and is predicted to increase rapidly with an ageing population and escalating rate of obesity. Autologous blood-derived products possess much promise in the repair and regeneration of tissue and have important roles in inflammation, angiogenesis, cell migration and metabolism in pathological conditions, including OA. Read More

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http://dx.doi.org/10.1007/s00441-019-02996-xDOI Listing
February 2019

The ACL-deficient knee and the prevalence of meniscus and cartilage lesions: a systematic review and meta-analysis (CRD42017076897).

Arch Orthop Trauma Surg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Orthopädie und Unfallchirurgie am Martin Luther Krankenhaus, Berlin, Caspar Theysstr. 27-31, 14193, Berlin, Germany.

Introduction: The purpose of this systematic review and meta-analysis was to analyze and compare the rate of secondary meniscus and cartilage lesions diagnosed at different time points of ACL reconstruction.

Materials And Methods: A systematic search for articles comparing the rate of secondary meniscus and cartilage lesions diagnosed at different time points of ACL reconstruction was performed. PubMed central was the database used for the literature review. Read More

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http://dx.doi.org/10.1007/s00402-019-03128-4DOI Listing
February 2019

Knee Joint Distraction Compared with High Tibial Osteotomy and Total Knee Arthroplasty: Two-Year Clinical, Radiographic, and Biochemical Marker Outcomes of Two Randomized Controlled Trials.

Cartilage 2019 Feb 13:1947603519828432. Epub 2019 Feb 13.

1 Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

Objective: Both, knee joint distraction (KJD) and high tibial osteotomy (HTO) are joint-preserving surgeries that postpone total knee arthroplasty (TKA) in younger osteoarthritis (OA) patients. Here we evaluate the 2-year follow-up of KJD versus TKA and KJD versus HTO in 2 noninferiority studies.

Design: Knee OA patients indicated for TKA were randomized to KJD ( n = 20; KJD) or TKA ( n = 40). Read More

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http://dx.doi.org/10.1177/1947603519828432DOI Listing
February 2019

A prospective study of health conditions related to alcohol consumption cessation among 97,852 drinkers aged 45 and over in Australia.

Alcohol Clin Exp Res 2019 Feb 13. Epub 2019 Feb 13.

Cancer Research Division, Cancer Council New South Wales, PO Box 572, KINGS CROSS, NSW, 1340, AUSTRALIA.

Background: Evidence suggests that people who develop serious health conditions are likely to cease drinking alcohol (sometimes known as 'sick-quitters'). We quantified the likelihood of quitting drinking in relation to the onset of a variety of health conditions.

Methods: Odds ratios (OR) and 95% confidence intervals (CI) of ceasing alcohol consumption after diagnosis of 28 health conditions and four general indicators of health were derived from logistic regression among 97,852 drinkers aged ≥45 years between baseline (2006-2009) and median 5. Read More

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http://dx.doi.org/10.1111/acer.13981DOI Listing
February 2019

Superior migration of the femoral head in patients with severe hip osteoarthritis influences the gait patterns of the coronal plane.

Hip Int 2019 Feb 13:1120700019827250. Epub 2019 Feb 13.

1 Department of Rehabilitation Medicine, Gunma University Graduate School of Medicine, Gunma, Japan.

Introduction:: Patients with hip osteoarthritis (OA) show abnormal movement patterns, including the leaning of the trunk toward the affected limb (Duchenne limp). Patients with severe OA, especially those with OA due to hip dysplasia, show a lateral pelvic drop (Trendelenburg sign).

Aim:: The aim of this preoperative study is to investigate the relationship between superior migration of the arthritic femoral head, pain, and hip abductor muscle strength, and to clarify the relationship between the coronal plane gait patterns with pain and hip abductor muscle strength. Read More

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http://dx.doi.org/10.1177/1120700019827250DOI Listing
February 2019

Intra-articular injection of mesenchymal stem cells for clinical outcomes and cartilage repair in osteoarthritis of the knee: a meta-analysis of randomized controlled trials.

Arch Orthop Trauma Surg 2019 Feb 11. Epub 2019 Feb 11.

Department of Orthopedic Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, 06973, Seoul, South Korea.

Introduction: Mesenchymal stem cells (MSCs) have gained popularity for articular cartilage repair. However, efficacy of intra-articular MSCs in osteoarthritis remains unclear. In the setting of a meta-analysis of randomized controlled trials (RCTs), we aimed to investigate the efficacy of intra-articular MSCs on clinical outcomes and cartilage repair in patients with knee osteoarthritis. Read More

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http://dx.doi.org/10.1007/s00402-019-03140-8DOI Listing
February 2019

UniCAP offers a long term treatment for middle-aged patients, who are not revised within the first 9 years.

Knee Surg Sports Traumatol Arthrosc 2019 Feb 11. Epub 2019 Feb 11.

Department of Emergency Medicine, Hospital of Southern Jutland, Kresten Philipsensvej 15, 6200, Aabenraa, Denmark.

Purpose: The aim of this study was to investigate the long-term outcome of the unicompartmental knee resurfacing prosthesis (UniCAP) using clinical and radiographic assessments, and to evaluate the revision and survival rates.

Methods: This was a prospective cohort study of patients with UniCAP prostheses with 6-9 years of follow-up. The clinical examination included the Knee Society Score (KSS) and Visual Analogue Scale (VAS) score. Read More

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http://dx.doi.org/10.1007/s00167-019-05356-yDOI Listing
February 2019

Increased HIF-1 in Knee Osteoarthritis Aggravate Synovial Fibrosis via Fibroblast-Like Synoviocyte Pyroptosis.

Oxid Med Cell Longev 2019 10;2019:6326517. Epub 2019 Jan 10.

Department of Orthopedics, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Fibroblast-like synoviocytes (FLSs) are the main effector cells of knee osteoarthritis (KOA) synovial fibrosis. Our last report showed that NLRP1 and NLRP3 inflammasomes may mediate LPS/ATP-induced FLSs pyroptosis in KOA. In the present study, we found an elevated hypoxia-inducible factor-1 (HIF-1) level in the synovial tissue of KOA model rats, and inhibiting the increase of HIF-1 could improve synovial fibrosis in rats. Read More

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http://dx.doi.org/10.1155/2019/6326517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348923PMC
January 2019

Primary Total Hip Arthroplasty in Severe Dysplastic Hip Osteoarthritis With a Far Proximal Cup Position.

J Arthroplasty 2019 Jan 23. Epub 2019 Jan 23.

Endogap, Joint Replacement Institute, Garmisch-Partenkirchen Medical Center, Garmisch-Partenkirchen, Germany.

Background: Developmental hip dysplasia is the most common cause of secondary hip osteoarthritis. Due to severe acetabular bone deficiency, cup positioning in total hip arthroplasty (THA) of dysplastic hips remains a surgical challenge. The aim was to analyze the functional outcome of far proximal cup positions in primary THA. Read More

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http://dx.doi.org/10.1016/j.arth.2019.01.032DOI Listing
January 2019

Effects of a valgus unloader brace in the medial meniscectomized knee joint: a biomechanical study.

J Orthop Surg Res 2019 Feb 12;14(1):44. Epub 2019 Feb 12.

Engineering Product Development (EPD) Pillar, Singapore University of Technology and Design (SUTD), 8 Somapah Road, Singapore, 487372, Singapore.

Background: Patients undergoing total or partial arthroscopic meniscectomy for treating traumatic meniscal tears are at greater risk of developing knee osteoarthritis (OA) due to increased mechanical load. The purpose of this study was to evaluate the effects of a valgus unloader brace in the medial meniscectomized knee joint during the gait cycle.

Methods: A three-dimensional finite element model of the knee joint was developed using the substructures segmented from magnetic resonance images. Read More

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http://dx.doi.org/10.1186/s13018-019-1085-1DOI Listing
February 2019
1.577 Impact Factor

Mid-term results with a neck-preserving femoral stem for total hip arthroplasty.

Hip Int 2018 Nov;28(2_suppl):28-34

1 Joint Replacement Division, Department of Orthopedic Surgery and Trauma, ASST Niguarda Hospital, Milan, Italy.

Introduction:: This prospective study aims to evaluate the mid-term clinical and radiological performance of a new short, neck-preserving femoral stem in total hip arthroplasty (THA).

Patients And Methods:: 178 consecutive patients (190 hips) underwent THA from November 2008 to July 2016. Mean follow-up is 62. Read More

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http://dx.doi.org/10.1177/1120700018813216DOI Listing
November 2018

Double-trabecular metal cup technique for the management of Paprosky type III defects without pelvic discontinuity.

Hip Int 2018 Nov;28(2_suppl):66-72

2 Hip Diseases and Joint Replacement Surgery Unit, Humanitas Clinical and Research Centre, Milan, Italy.

Introduction:: Modular reconstruction systems based on trabecular metal (TM) prosthetic components have been increasingly used in the last decade for the management of severe acetabular bone defects. The aim of this study was to assess the clinical and radiographic outcomes of double-cup technique for the management of Paprosky type III defects without pelvic discontinuity.

Methods:: A retrospective review was performed for all patients undergoing acetabular reconstruction with 2 TM cups at a tertiary referral centre between 2010 and 2015. Read More

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http://dx.doi.org/10.1177/1120700018813208DOI Listing
November 2018

Stemless hip arthroplasty versus traditional implants: a comparative observational study at 30 months follow-up.

Hip Int 2018 Nov;28(2_suppl):21-27

Department of Orthopaedics, Università Cattolica del Sacro Cuore-Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Introduction:: The aim of this retrospective case-control study is to evaluate clinical and radiographic results of short stems compared with traditional hip prostheses.

Methods:: 46 short stems (SS) and 50 traditional stems (TS) were selected. All the stems were implanted by the same surgeon using posterior approach because of primary osteoarthritis, post-traumatic osteoarthritis and avascular necrosis. Read More

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http://dx.doi.org/10.1177/1120700018813209DOI Listing
November 2018

Is there still a role for threaded acetabular cups?

Hip Int 2018 Nov;28(2_suppl):15-20

1 U.O. Complex II Division, Gaetano Pini Orthopaedic Institute, Milan, Italy.

Introduction:: Total hip arthroplasty (THA) is 1 of the most common procedures in orthopaedic surgery. Different options and implants are currently available. Uncemented hip cups need primary stability for bone ingrowth, the use of screws is required when the desired stability is not achieved. Read More

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http://dx.doi.org/10.1177/1120700018813210DOI Listing
November 2018
1 Read

Matrix Metalloproteinases and Their Inhibitors and Proteoglycan 4 in Patients Undergoing Total Joint Arthroplasty.

Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029619828113

2 Department of Orthopedics, Loyola University Medical Center, Maywood, IL, USA.

Osteoarthritis, a degenerative disease of the joints, is the most common form of arthritis in the knee. Total joint arthoplasty is a commonly used treatment for joint degeneration and osteoarthritis, and due to these factors, TJA for hip and knee joints is projected to grow by 137% and 601% between 2005 and 2030. Matrix metalloproteases are enzymes found in the extracellular matrix that cleave matrix components. Read More

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http://dx.doi.org/10.1177/1076029619828113DOI Listing
February 2019

[Multimorbidity and Disease Severity Measured by the Charlson Index in Portuguese Hospitalised Patients During the Year 2015: A Cross-Sectional Study].

Acta Med Port 2019 Feb 1;32(1):38-46. Epub 2019 Feb 1.

Departamento de Saúde Pública. Escola Nacional de Saúde Pública. Universidade NOVA de Lisboa. Lisboa. Portugal.

Introduction: The association between multimorbidity and disease severity is not well established. The objectives were to characterise multimorbidity and determine disease severity (trough Charlson), as well as to verify if there is an association between the number and type of disease and the Charlson index.

Material And Methods: A cross-sectional study based on exported data from the Portuguese National Health Service hospitalisations database, during the year 2015. Read More

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http://dx.doi.org/10.20344/amp.9728DOI Listing
February 2019
1 Read

Minimum 10-Year Results of Single- Versus Double-Bundle Posterior Cruciate Ligament Reconstruction: Clinical, Radiologic, and Survivorship Outcomes.

Am J Sports Med 2019 Feb 12:363546518825257. Epub 2019 Feb 12.

Department of Orthopaedic Surgery, Kyung Hee University Hospital, Seoul, Republic of Korea.

Background:: Biomechanical studies have shown that double-bundle (DB) posterior cruciate ligament reconstruction (PCLR) is better than single-bundle (SB) PCLR in restoring normal biomechanical function and stability. However, most clinical studies report no differences between the technical methods, and there is yet no long-term clinical comparative study.

Hypothesis:: DB PCLR would show superior results and survivorship outcomes to those of SB PCLR in long-term follow-up. Read More

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http://dx.doi.org/10.1177/0363546518825257DOI Listing
February 2019
4.362 Impact Factor