79,867 results match your criteria Osteoarthritis


Long non-coding RNA THRIL promotes LPS-induced inflammatory injury by down-regulating microRNA-125b in ATDC5 cells.

Int Immunopharmacol 2018 Dec 3;66:354-361. Epub 2018 Dec 3.

Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun 130033, China. Electronic address:

Background: Osteoarthritis is an age-related disorder of bone-joint that causes pain and disability in middle and older people. This study aimed to investigate the potential effects of long non-coding RNA (lncRNA) THRIL on lipopolysaccharide (LPS)-induced osteoarthritis cell injury model (ATDC5 cell inflammatory injury), as well as the possible internal molecular mechanisms.

Methods: Cell viability and apoptosis were assessed using CCK-8 assay and Guava Nexin assay, respectively. Read More

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December 2018
2 Reads

Ivabradine abrogates TNF-α-induced degradation of articular cartilage matrix.

Int Immunopharmacol 2018 Dec 3;66:347-353. Epub 2018 Dec 3.

Department of orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China. Electronic address:

Ivabradine is most commonly used for the treatment of worsening cardiac failure in patients who cannot tolerate the maximum dose of β-blockers or in whom treatment with β-blockers is contraindicated. While ivabradine is regarded as a highly selective "funny current" (I) inhibitor, the molecular mechanism behind the effect of this drug remains poorly understood. In the present study, we applied ivabradine in the context of osteoarthritis by treating primary human chondrocytes with tumor necrosis factor-α (TNF-α) and measuring degradation of the articular cartilage matrix as well as the expression of various enzymes and pro-inflammatory cytokines. Read More

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December 2018
4 Reads

MiR-15b is a key regulator of proliferation and apoptosis of chondrocytes from patients with condylar hyperplasia by targeting IGF1, IGF1R and BCL2.

Osteoarthritis Cartilage 2018 Dec 3. Epub 2018 Dec 3.

Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei province, China. Electronic address:

Objective: This study aimed to explore potential microRNAs (miRNAs), which participate in the pathological process of condylar hyperplasia (CH) through targeting specific proliferation- and apoptosis-related genes of chondrocytes.

Methods: Insulin-like growth factor 1 (IGF1), IGF1 receptor (IGF1R) and B-cell CLL/lymphoma 2 (BCL2) in CH cartilage were detected by real-time PCR, Western blot, immunohistochemistry and immunofluorescence. MiRanda and TargetScanS algorithms were used to predict certain miRNAs in CH chondrocytes concurrently modulating the above three genes. Read More

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December 2018
1 Read

Healthcare Providers' Advice on Lifestyle Modification in the US Population: Results from the National Health and Nutrition Examination Survey 2011-2016.

Am J Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Epidemiology, Center for Public Health, Medical University of Vienna, Kinderspitalgasse 15/1, 1090 Vienna, Austria; Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Holy Cross Centre, 2210-2nd Street SW, Box ACB, Calgary, AB, T2S 3C3, Canada; Preventive Oncology & Community Health Sciences, Cumming School of Medicine, University of Calgary, Hospital Drive NW, Calgary, Alberta, Canada. Electronic address:

Objective: Healthcare providers are encouraged to prescribe lifestyle modifications for preventing and managing obesity and associated chronic conditions. However, the pattern of lifestyle advice provision is unknown. We investigate the prevalence of advised lifestyle modification according to weight status and chronic conditions in a US nationally representative sample. Read More

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December 2018

[Postoperative functional angular anatomy in patients with anterior cruciate ligament with autologous graft].

Acta Ortop Mex 2018 May-Jun;32(3):157-162

Servicio de Cirugía Articular, Hospital Juárez de México, Ciudad de México.

Background: Reconstruction of the anterior cruciate ligament (ACL) aims to restore the original anatomy. The clinical outcome could be imperfect when graft placement is not in an anatomical position; moreover, the conventional transtibial reconstruction of the ACL often locates the graft away from the anatomical site, leading to abnormal biomechanical behavior and kinematics of the knee. The objective of this work was to assess the importance of the angular reconstruction of the anterior cruciate ligament during arthroscopic replacement and to compare the postoperative functional results. Read More

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December 2018

Pain characterization and response to palliative care in dogs with naturally-occurring appendicular osteosarcoma: An open label clinical trial.

PLoS One 2018 6;13(12):e0207200. Epub 2018 Dec 6.

GREPAQ (Groupe de recherche en pharmacologie animale du Québec), Department of biomedical sciences, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, Quebec, Canada.

This study aimed to characterize bone cancer pain (quantitative sensory testing (QST), stance asymmetry index, actimetry, scores of pain and quality of life (QoL)) in dogs with appendicular osteosarcoma (OSA), and to evaluate a stepwise palliative analgesic treatment. The pain profile of thirteen client-owned dogs with OSA was compared with seven healthy dogs. Dogs with OSA were then enrolled in a prospective, open-label, clinical trial. Read More

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December 2018

Intra-articular injection of hydrogen sulfide decreased the progression of gonarthrosis.

Can J Physiol Pharmacol 2018 Dec 6:1-8. Epub 2018 Dec 6.

d Department of Pharmacology, University of Giresun, Giresun, Turkey.

Hydrogen sulfide (HS) is found in both the plasma and synovial fluid of patients with gonarthrosis. In the present study, we investigated whether intra-articular injection of sodium hydrosulfide (NaSH) (1 mM, 30 μL), a HS donor, might affect gonarthrosis in rats. Gonarthrosis was induced surgically in the left knees of rats and left for 6 weeks for the development of disease. Read More

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December 2018
4 Reads

Diffuse Tibiofemoral Cartilage Change Prior to the Development of Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative.

Clin Anat 2018 Dec 6. Epub 2018 Dec 6.

Division of Rheumatology, Allergy, and Immunology, Tufts Medical Center, Boston, MA, USA.

Introduction: We compared the spatial distribution of tibiofemoral cartilage change between individuals who will develop accelerated knee osteoarthritis (KOA) versus typical onset of KOA prior to the development of radiographic KOA.

Materials And Methods: We conducted a longitudinal case-control analysis of 129 individuals from the Osteoarthritis Initiative. We assessed the percent change in tibiofemoral cartilage on magnetic resonance images at 36 informative locations from two to one year prior to the development of accelerated (n=44) versus typical KOA (n=40). Read More

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December 2018

Fingerprint pattern of bone mineralisation on cemented and uncemented femoral stems: analysis by [18F]-fluoride-PET in a randomised clinical trial.

Hip Int 2018 Dec 6:1120700018815404. Epub 2018 Dec 6.

4 Depaetment of Orthopaedics, Uppsala University Hospital, Sweden.

Purpose:: We present a randomised clinical study using 18F-fluoride positron emission tomography/computed tomography (F-PET/CT) to analyse the osteoblastic part of bone metabolism (new bone mineralisation) in periprosthetic bone adjacent to femoral stems following total hip arthoplasty (THA) surgery. Patients with hip osteoarthritis were randomly assigned to THA surgery with cemented or uncemented femoral components.

Patients And Methods:: THA was performed on 26 patients (26 cases) with hip osteoarthritis. Read More

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December 2018
1 Read

Local Tensile Stress in the Development of Posttraumatic Osteoarthritis.

Biomed Res Int 2018 4;2018:4210353. Epub 2018 Nov 4.

Orthopedic Institute, Medical College, Soochow University, Suzhou, Jiangsu 215006, China.

The pathogenesis of posttraumatic osteoarthritis (PTOA) remains unrevealed. We speculate that cartilage crack caused by joint trauma will induce local abnormal tensile stress, leading to change in extracellular matrix (ECM) expression of chondrocytes, cartilage degeneration, and initiation of osteoarthritis. Finite element model was used to examine whether the local tensile stress could be produced around the crack. Read More

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November 2018

Penetration and efficacy of transdermal NSAIDs in a model of acute joint inflammation.

J Pain Res 2018 13;11:2809-2819. Epub 2018 Nov 13.

InterVivo Solutions Inc, Toronto, ON, Canada.

Purpose: Prescription and OTC non-steroidal anti-inflammatory drugs (NSAIDs) are ubiquitous treatments for pain and inflammation; however, oral administration of these drugs may produce gastrointestinal (GI) side effects. Transdermal (TD) administration of NSAIDs circumvents these adverse events by avoiding the GI tract and, presumably, achieves regional drug levels of therapeutic effect and thereby, fewer off-target complications.

Methods: A drug quantification method was developed for ibuprofen and celecoxib in canine plasma and synovial fluid using liquid chromatography and mass spectrometry. Read More

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November 2018

The efficacy of electromyographic biofeedback on pain, function, and maximal thickness of vastus medialis oblique muscle in patients with knee osteoarthritis: a randomized clinical trial.

J Pain Res 2018 8;11:2781-2789. Epub 2018 Nov 8.

Department of Sport Sciences, Payame Noor University, Tehran, Iran.

Introduction: The aim of this survey was to examine the effect of adding electromyographic biofeedback (EMGBF) to isometric exercise, on pain, function, thickness, and maximal electrical activity in isometric contraction of the vastus medialis oblique (VMO) muscle in patients with knee osteoarthritis (OA).

Methods: In this clinical trial, 46 patients with a diagnosis of knee OA were recruited and assigned to two groups. The case group consisted of 23 patients with EMGBF-associated exercise, and the control group was made up of 23 patients with only isometric exercise. Read More

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November 2018
1 Read

Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis.

Cell Death Dis 2018 Dec 5;9(12):1166. Epub 2018 Dec 5.

CellCOM research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña (UDC), Xubias de Arriba, 84, 15006 A, Coruña, Spain.

Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and senescence, restricting cartilage regeneration and favouring disease progression. Similar to other wound-healing disorders, chondrocytes from OA patients show a chronic increase in the gap junction channel protein connexin43 (Cx43), which regulates signal transduction through the exchange of elements or recruitment/release of signalling factors. Read More

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December 2018

Assessment of osteoarthritic features in the thumb base with the newly developed OMERACT magnetic resonance imaging scoring system is a valid addition to standard radiography.

Osteoarthritis Cartilage 2018 Nov 30. Epub 2018 Nov 30.

Departments of Rheumatology, Leiden University Medical Center (LUMC), Leiden, the Netherlands; Clinical Epidemiology, Leiden University Medical Center (LUMC), Leiden, the Netherlands. Electronic address:

Objective: To investigate the construct validity of the new thumb base OA MRI scoring system (TOMS) by comparing TOMS scores with radiographic scores in patients with primary hand OA.

Design: In 200 patients (83.5% women, mean (SD) age 61. Read More

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November 2018

Squatting versus squatting with hip adduction in management of patellofemoral osteoarthritis: A randomized controlled trial.

J Back Musculoskelet Rehabil 2018 Nov 23. Epub 2018 Nov 23.

Department of Physical Therapy, Faculty of Health Sciences, Beirut Arab University, Beirut, Lebanon.

Background: Patellofemoral osteoarthritis is a common presentation in the outpatients' physical therapy clinics. The muscle imbalance between the vastus medialis oblique and vastus lateralis muscles is one of the main factors that lead to the development of this condition.

Objective: To compare the effect of a squatting versus squatting with hip adduction in management of patellofemoral osteoarthritis. Read More

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November 2018
4 Reads

Novel nano-microspheres containing chitosan, hyaluronic acid, and chondroitin sulfate deliver growth and differentiation factor-5 plasmid for osteoarthritis gene therapy.

J Zhejiang Univ Sci B 2018 Dec.;19(12):910-923

Institute of Tissue Engineering and Stem Cells, Nanchong Central Hospital, the Second Clinical Medical College of North Sichuan Medical College, Nanchong 637000, China.

Objective: To construct a novel non-viral vector loaded with growth and differentiation factor-5 (GDF-5) plasmid using chitosan, hyaluronic acid, and chondroitin sulfate for osteoarthritis (OA) gene therapy.

Methods: Nano-microspheres (NMPs) were prepared by mixing chitosan, hyaluronic acid, and chondroitin sulfate. GDF-5 plasmid was encapsulated in the NMPs through electrostatic adsorption. Read More

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December 2018

Cryptotanshinone inhibits RANKL-induced osteoclastogenesis by regulating ERK and NF-κB signaling pathways.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Department of Orthopedics, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.

Osteoporosis (OS) is one of the most common healthy problems characterized by low bone mass. Osteoclast, the primary bone-resorbing cell, is responsible for destructive bone diseases including osteoporosis (OS). Cryptotanshinone (CTS), an active component extracted from the root of Salvia miltiorrhiza bunge, has been shown to prevent the destruction of cartilage and the thickening of subchondral bone in mice osteoarthritis models. Read More

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December 2018

Shared KEGG pathways of icariin-targeted genes and osteoarthritis.

J Cell Biochem 2018 Dec 3. Epub 2018 Dec 3.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The beneficial effects of icariin in the management of many diseases, such as chronic renal failure and heart failure, are well known. Icariin has also been shown to ameliorate osteoarthritis (OA) symptoms; however, the underlying mechanisms remain unclear. In this study, a bioinformatics analysis was performed to investigate the KEGG pathways of icariin-targeted genes involved in OA. Read More

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December 2018

The Impact of Excluding Patients with End-Stage Knee Disease in Intra-Articular Hyaluronic Acid Trials: A Systematic Review and Meta-Analysis.

Adv Ther 2018 Dec 1. Epub 2018 Dec 1.

Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.

Introduction: The Kellgren-Lawrence (K-L) grade is the most commonly used measure of radiographic disease severity in knee osteoarthritis (OA). Studies suggest that intra-articular hyaluronic acid (IA-HA) should only be considered in cases of early stage knee OA. The purpose of this review was to determine if trials administering IA-HA in early-moderate knee OA patients demonstrated greater pain relief than studies that also included patients with end-stage disease. Read More

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December 2018
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Immunological modulation following bone marrow-derived mesenchymal stromal cells and Th17 lymphocyte co-cultures.

Inflamm Res 2018 Nov 30. Epub 2018 Nov 30.

Osteoarthritis Research Unit, Department of Medicine, University of Montreal Hospital Research Center (CRCHUM), 900 rue Saint-Denis, R11.424, Montreal, QC, H2X 0A9, Canada.

Objective And Design: The objective of the study is to uncover the influence of human bone marrow-derived mesenchymal stem cells (BM-MSCs) on the generation of Th17 lymphocytes in co-cultures of both BM-MSCs and T cells.

Materials And Methods: BM-MSCs, characterized according to the international society for cellular therapy (ISCT) criteria, were co-cultured with T cells isolated from peripheral blood. The expression levels of IL-17 receptor, RORγt and IL-23 receptor were evaluated using flow cytometry. Read More

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November 2018

Development of a clinical risk score for pain and function following total knee arthroplasty: results from the TRIO study.

Rheumatol Adv Pract 2018 29;2(2):rky021. Epub 2018 May 29.

Epidemiology Group, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen.

Objectives: The aim was to develop and validate a simple clinical prediction model, based on easily collected preoperative information, to identify patients at high risk of pain and functional disability 6 months after total knee arthroplasty (TKA).

Methods: This was a multicentre cohort study of patients from nine centres across the UK, who were undergoing a primary TKA for OA. Information on sociodemographic, psychosocial, clinical and quality-of-life measures were collected at recruitment. Read More

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Cost-utility analysis of interventions to improve effectiveness of exercise therapy for adults with knee osteoarthritis: the BEEP trial.

Rheumatol Adv Pract 2018 6;2(2):rky018. Epub 2018 Jun 6.

Arthritis Research UK Primary Care Centre, Research Institute of Primary Care and Health Sciences, Keele University, Keele, Staffordshire, UK.

Objectives: Evidence regarding the cost-effectiveness of enhancing physical therapy exercise programmes in order to improve outcomes for patients with knee OA remains unclear. This study investigates the cost-effectiveness of two enhanced physical therapy interventions compared with usual physical therapy care (UC) for adults with knee OA.

Methods: A trial-based cost-utility analysis of individually tailored exercise (ITE) or targeted exercise adherence (TEA) compared with UC was undertaken over a period of 18 months. Read More

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June 2018
1 Read

Poor Performance on Single-Legged Hop Tests Associated With Development of Posttraumatic Knee Osteoarthritis After Anterior Cruciate Ligament Injury.

Orthop J Sports Med 2018 Nov 26;6(11):2325967118810775. Epub 2018 Nov 26.

Biomechanics and Movement Science Program, University of Delaware, Newark, Delaware, USA.

Background: The risk for knee osteoarthritis (OA) is substantially increased after anterior cruciate ligament (ACL) injury. Tools are needed to identify characteristics of patients after ACL injury who are most at risk for posttraumatic OA.

Purpose: To determine whether clinical measures of knee function after ACL injury are associated with the development of radiographic knee OA 5 years after injury. Read More

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November 2018
1 Read

Remaining Loose Bodies after Arthroscopic Surgery Including Extensive Capsulectomy for Synovial Chondromatosis of the Hip.

Clin Orthop Surg 2018 Dec 21;10(4):393-397. Epub 2018 Nov 21.

Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Background: The purpose of our study was to evaluate the usefulness of hip arthroscopy including extensive capsulectomy for synovial chondromatosis of the hip.

Methods: From 2008 to 2016, 13 patients with synovial chondromatosis of the hip were treated with arthroscopic removal of loose bodies and synovectomy using three arthroscopic portals. An extensive capsulectomy was performed to allow the remaining loose bodies to be out of the extracapsular space, and the excised capsule was not repaired. Read More

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December 2018

The diagnostic value and pathogenetic role of lncRNA-ATB in patients with osteoarthritis.

Cell Mol Biol Lett 2018 27;23:55. Epub 2018 Nov 27.

Second Department of Orthopaedics, Wei Nan Central Hospital, Weinan, 714000 Shanxi Province People's Republic of China.

Background: In view of the roles of long non-coding RNAs (lncRNAs) in human diseases and the high incidence of osteoarthritis, we investigated the role of long non-coding RNA activated by transforming growth factor-β (lncRNA-ATB) in osteoarthritis and explored its diagnostic value for this disease.

Methods: The study involved 98 patients with osteoarthritis and 76 healthy subjects. Blood was extracted from each participant and the expression of lncRNA-ATB in the serum was detected using quantitative Real Time -PCR. Read More

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November 2018

α-Microglobulin Protects Against Bleeding-Induced Oxidative Damage in Knee Arthropathies.

Front Physiol 2018 16;9:1596. Epub 2018 Nov 16.

Department of Clinical Sciences Lund, Orthopaedics, Faculty of Medicine, Lund University, Lund, Sweden.

Knee injury increases the risk of developing knee osteoarthritis (OA). Recent evidence suggests involvement of oxidative stress induced by inflammation and bleeding in the joint. This study investigates the role in this process of α-microglobulin (A1M), a plasma and tissue antioxidant protein with reducing function, and heme- and radical-binding properties. Read More

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November 2018
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Endoplasmic Reticulum Stress Is Involved in Baicalin Protection on Chondrocytes From Patients With Osteoarthritis.

Dose Response 2018 Oct-Dec;16(4):1559325818810636. Epub 2018 Nov 25.

Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China.

Osteoarthritis (OA) affects elderly population worldwide and endoplasmic reticulum (ER) stress is known to be positively correlated with OA development. Previous reports prove the cytoprotective effects of baicalin on chondrocytes, whereas the mechanisms are hardly reported. Hence, we aimed to investigate the links between OA, ER stress, and baicalin. Read More

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November 2018

Morin Exhibits Anti-Inflammatory Effects on IL-1β-Stimulated Human Osteoarthritis Chondrocytes by Activating the Nrf2 Signaling Pathway.

Cell Physiol Biochem 2018 Nov 30;51(4):1830-1838. Epub 2018 Nov 30.

Background/aims: Osteoarthritis (OA) is a multifactorial disease that is associated with inflammation in joints. The purpose of the present study was to investigate the anti-inflammatory activity and mechanism of morin on human osteoarthritis chondrocytes stimulated by IL-1β.

Methods: The levels of NO and PGE2 were measured by the Griess method and ELISA. Read More

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November 2018

Characteristics of Accelerated Hand Osteoarthritis: Data from the Osteoarthritis Initiative.

J Rheumatol 2018 Dec 1. Epub 2018 Dec 1.

From the Division of Rheumatology, Tufts Medical Center; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, Rhode Island, USA; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway. These analyses were financially supported by grants from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number R01-AR065977 and Award Number R01-AR066378. This work was also supported in part by the Houston Veterans Affairs Health Services Research and Development Center of Excellence (HFP90-020). The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs. J.E. Davis, BS, Research Assistant II, Division of Rheumatology, Tufts Medical Center; L.F. Schaefer, MD, Radiology Fellow, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; T.E. McAlindon, MD, MPH, Chief of Rheumatology, Division of Rheumatology, Tufts Medical Center; C.B. Eaton, MD, MS, Professor of Family Medicine and Epidemiology, Director of Center for Primary Care and Prevention, Alpert Medical School of Brown University; M.B. Roberts, MSc, Statistical Programmer, Center for Primary Care and Prevention, Alpert Medical School of Brown University; I.K. Haugen, MD, PhD, Rheumatology Fellow, Department of Rheumatology, Diakonhjemmet Hospital; S.E. Smith, MD, Section Head and Weissman Distinguished Chair of Musculoskeletal Radiology, Associate Radiology Residency Program Director, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; J. Duryea, PhD, Associate Research Associate, Associate Professor of Radiology, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; B. Lu, DrPH, MD, Assistant Professor of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School; J.B. Driban, PhD, ATC, CSCS, Associate Professor, Division of Rheumatology, Tufts Medical Center. Address correspondence to J.B. Driban, Division of Rheumatology, Tufts Medical Center; 800 Washington St., Box 406, Boston, Massachusetts 02111, USA. E-mail: Accepted for publication August 15, 2018.

Objective: We aimed to determine whether hand joints develop an accelerated form of osteoarthritis (OA) and to characterize individuals who develop accelerated hand osteoarthritis (AHOA).

Methods: We evaluated 3519 participants in the Osteoarthritis Initiative with complete data for baseline and 48-month radiographic hand osteoarthritis (HOA). One reader scored posteroanterior radiographs of the dominant hand using a modified Kellgren-Lawrence (KL) scale and another reader scored the presence of central or marginal erosions. Read More

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December 2018

Effectiveness of low-dose radiation therapy on symptoms in patients with knee osteoarthritis.

Ann Rheum Dis 2018 Dec 1. Epub 2018 Dec 1.

Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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December 2018
2 Reads

RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage.

Ann Rheum Dis 2018 Dec 1. Epub 2018 Dec 1.

Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

Objective: To uncover the microRNA (miRNA) interactome of the osteoarthritis (OA) pathophysiological process in the cartilage.

Methods: We performed RNA sequencing in 130 samples (n=35 and n=30 pairs for messenger RNA (mRNA) and miRNA, respectively) on macroscopically preserved and lesioned OA cartilage from the same patient and performed differential expression (DE) analysis of miRNA and mRNAs. To build an OA-specific miRNA interactome, a prioritisation scheme was applied based on inverse Pearson's correlations and inverse DE of miRNAs and mRNAs. Read More

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December 2018
5 Reads

Evaluation of the effect of signalment and owner-reported impairment level on accelerometer-measured changes in activity in osteoarthritic dogs receiving a non-steroidal anti-inflammatory.

Vet J 2018 Dec 17;242:48-52. Epub 2018 Oct 17.

Translational Research in Pain, Comparative Pain Research and Education Centre, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA; Department of Veterinary Clinical Sciences, Louisiana State University, School of Veterinary Medicine, Baton Rouge, LA, USA; Center for Pain Research and Innovation, UNC School of Dentistry, Chapel Hill, NC, USA; Center for Translational Pain Research, Department of Anesthesiology, Duke University, Durham, NC, USA. Electronic address:

In veterinary medicine, evaluation of osteoarthritis (OA) treatment efficacy remains challenging. Measurement of activity, utilizing accelerometers, provides a surrogate measure of pain through measuring effects on activity, and the objective data collected can be used to assess the efficacy of treatments. However, little is known about how dog characteristics impact the accelerometry-measured response to treatment. Read More

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December 2018

Complications Associated With Medial Opening-Wedge High Tibial Osteotomy Using a Locking Plate: A Multicenter Study.

J Arthroplasty 2018 Nov 14. Epub 2018 Nov 14.

Department of Orthopaedic Surgery, Korea University Anam Hospital, Korea University School of Medicine, Seoul, South Korea.

Background: The aim of this study is to investigate complications following medial opening-wedge high tibial osteotomy using a locking plate. In addition, we aimed to compare postoperative outcomes between the complicated and the uncomplicated group.

Methods: This study enrolled 209 patients who underwent medial opening-wedge high tibial osteotomy between 2010 and 2015. Read More

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November 2018

The Long-Term Results of Simultaneous High-Flexion Mobile-Bearing and Fixed-Bearing Total Knee Arthroplasties Performed in the Same Patients.

J Arthroplasty 2018 Nov 12. Epub 2018 Nov 12.

The Joint Replacement Center, Ewha Womans University Mokdong Hospital, Seoul, Republic of Korea.

Background: Our study determined the long-term clinical, radiographic, and computed tomography scanning results of high-flexion mobile-bearing and fixed-bearing total knee arthroplasties (TKAs) in the same younger patients. In addition, the survivorship and complication rates of both groups were evaluated.

Methods: Bilateral simultaneous sequential TKAs were performed in 164 patients (328 knees). Read More

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November 2018

The critical shoulder angle: can it be sufficient to reflect the shoulder joint without the humeral head?

J Shoulder Elbow Surg 2018 Nov 30. Epub 2018 Nov 30.

Shoulder & Elbow Clinic, Department of Orthopaedic Surgery, College of Medicine, Kyung Hee University, Seoul, Republic of Korea. Electronic address:

Hypothesis: We hypothesized that a new method considering the humeral head would distinguish rotator cuff tears (RCTs) and osteoarthritis (OA) better than the critical shoulder angle (CSA).

Methods: A total of 1011 patients were tested in this study and divided into 4 groups: those with RCTs (n = 493), those with OA (n = 73), those with anterior instability (n = 361), and those with adhesive capsulitis (n = 84). The CSA and new radiologic parameters including the humeral head were measured in the true anterior-to-posterior view: the Y angle connecting the lower end of the glenoid (LG), the center of the humeral head (CH), and the upper end of the glenoid (UG); the G angle connecting UG, CH, and the lateral tip of the acromion; the YG angle connecting LG, CH, and the lateral tip of the acromion; and the R angle connecting UG, LG, and CH. Read More

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November 2018

Doctor, when can I drive? - Range of motion of the knee while driving a car.

Knee 2018 Nov 29. Epub 2018 Nov 29.

Department of Trauma and Hand Surgery, University Hospital, Moorenstrasse 5, 40225 Düsseldorf, Germany.

Background: One of the most important activities of daily living is operating a motor vehicle. With increasing age the prevalence of musculoskeletal disorders such as knee osteoarthritis may interfere with an individual's ability to do so safely. Physicians are tasked with determining a patient's ability to drive and yet the necessary joint range of motion required for driving a car has not been characterized. Read More

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November 2018

The prevalence of cam hip morphology in a general population sample.

Osteoarthritis Cartilage 2018 Nov 28. Epub 2018 Nov 28.

University of Warwick. Electronic address:

Objective: Cam hip morphology is associated with femoroacetabular impingement (FAI) syndrome and causes hip osteoarthritis. We aimed to assess the prevalence of cam hip morphology in a sample representative of the general population, using a measure with a predefined diagnostic accuracy.

Design: Patients aged 16-65, who were admitted to a major trauma centre and received a CT pelvis were retrospectively screened for eligibility. Read More

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November 2018

TGFβi is involved in the chondrogenic differentiation of mesenchymal stem cells and is dysregulated in osteoarthritis.

Osteoarthritis Cartilage 2018 Nov 28. Epub 2018 Nov 28.

IRMB, University Montpellier, INSERM, CHU Montpellier, Montpellier, France; Hôpital Lapeyronie, Clinical immunology and osteoarticular diseases Therapeutic Unit, Montpellier, France. Electronic address:

Objective: Transforming growth factor-β (TGFβ) is a major regulator of cartilage homeostasis and its deregulation has been associated with osteoarthritis (OA). Deregulation of the TGFβ pathway in mesenchymal stem cells (MSCs) has been proposed to be at the onset of OA. Using a secretome analysis, we identified a member of the TGFβ family, TGFβ-induced protein (TGFβi or βIGH3), expressed in MSCs and we investigated its function and regulation during OA. Read More

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November 2018

Outcomes of hyaluronic acid injections for glenohumeral osteoarthritis: a systematic review and meta-analysis.

J Shoulder Elbow Surg 2018 Nov 28. Epub 2018 Nov 28.

Department of Surgery, McMaster University, Hamilton, ON, Canada. Electronic address:

Background: Hyaluronic acid (HA) is an analgesic and chondroprotective agent often used for the nonoperative treatment of osteoarthritis (OA). The effects of HA injections are well studied in the treatment of knee OA, but the effects in glenohumeral OA remain unclear. This study evaluated the efficacy of HA to reduce pain in patients with glenohumeral OA. Read More

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November 2018

The TeMPO trial (treatment of meniscal tears in osteoarthritis): rationale and design features for a four arm randomized controlled clinical trial.

BMC Musculoskelet Disord 2018 Dec 1;19(1):429. Epub 2018 Dec 1.

Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) and Policy and Innovation eValuation in Orthopedic Treatments (PIVOT), Department of Orthopaedic Surgery, Brigham and Women's Hospital, 60 Fenwood Road, BTM 5016, Boston, MA, 02115, USA.

Background: Meniscal tears often accompany knee osteoarthritis, a disabling condition affecting 14 million individuals in the United States. While several randomized controlled trials have compared physical therapy to surgery for individuals with knee pain, meniscal tear, and osteoarthritic changes (determined via radiographs or magnetic resonance imaging), no trial has evaluated the efficacy of physical therapy alone in these subjects.

Methods: The Treatment of Meniscal Tear in Osteoarthritis (TeMPO) Trial is a four-arm multi-center randomized controlled clinical trial designed to establish the comparative efficacy of two in-clinic physical therapy interventions (one focused on strengthening and one containing placebo) and two protocolized home exercise programs. Read More

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December 2018

Midterm Outcomes of a Synthetic Cartilage Implant for the First Metatarsophalangeal Joint in Advanced Hallux Rigidus.

Foot Ankle Int 2018 Dec 3:1071100718815469. Epub 2018 Dec 3.

13 Division of Orthopaedic Surgery, St. Michael's Hospital, Toronto, ON, Canada.

Background:: A prospective, randomized, noninferiority clinical trial of synthetic cartilage implant hemiarthroplasty for hallux rigidus demonstrated functional outcomes and safety equivalent to first metatarsophalangeal (MTP) joint arthrodesis at 24 months. We prospectively assessed safety and efficacy outcomes for synthetic cartilage implant hemiarthroplasty at a minimum of 5 years.

Methods:: Of 135 eligible patients from the original trial, 112 (83. Read More

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December 2018

The Effects of Needling Therapies on Muscle Force Production: A Systematic Review and Meta-Analysis.

J Orthop Sports Phys Ther 2018 Nov 30:1-38. Epub 2018 Nov 30.

Sports Medicine Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH.

Study Design: Systematic review with meta-analysis.

Background: Needling has been shown to decrease pain in the short-term; however, its effects on muscle force production are unclear.

Objective: Evaluate the evidence regarding the comparative effects of needling on muscle force production. Read More

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November 2018

Body Mass Index Mediates the Association between Dietary Fiber and Symptomatic Knee Osteoarthritis in the Osteoarthritis Initiative and the Framingham Osteoarthritis Study.

J Nutr 2018 Dec;148(12):1961-1967

Department of Medicine, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA.

Background: Dietary fiber reduces body weight and inflammation in clinical trials. It is unclear whether body mass index (BMI) and inflammation might explain the observed association between higher fiber intake and the lower risk of symptomatic knee osteoarthritis (SXKOA).

Objectives: We quantified the extent to which BMI and inflammation influenced the relation between dietary fiber and SXKOA. Read More

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December 2018
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Safety and Efficacy of Percutaneous Injection of Lipogems Micro-Fractured Adipose Tissue for Osteoarthritic Knees.

Am J Orthop (Belle Mead NJ) 2018 Nov;47(11)

197 Ridgedale Ave #210, Cedar Knolls, NJ 07927, USA. Email:

The aim of this study was to evaluate the safety and efficacy of using autologous, micro-fractured, minimally manipulated adipose tissue in patients with refractory knee osteoarthritis (OA). A total of 17 subjects (26 knees) with a median age of 72 years (range: 54-78 years) and a history of knee OA (Kellgren-Lawrence, grade of 3 or 4) underwent treatment with ultrasound-guided injection of micro-fractured adipose tissue. Micro-fractured fat was obtained using a minimal manipulation technique in a closed system (Lipogems), without the addition of enzymes or any other additives. Read More

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November 2018

Elite Rowers Demonstrate Consistent Patterns of Hip Cartilage Damage Compared With Matched Controls: A T2* Mapping Study.

Clin Orthop Relat Res 2018 Nov 27. Epub 2018 Nov 27.

B. Bittersohl, C. Benedikter, A. Franz. T. Hesper, R. Krauspe, C. Zilkens, Department of Orthopedics, University of Düsseldorf, Medical Faculty, Düsseldorf, Germany C. Schleich, G. Antoch, Department of Diagnostic and Interventional Radiology, University of Düsseldorf, Medical Faculty, Düsseldorf, Germany H. S. Hosalkar, Hosalkar Institute, San Diego, CA, USA; Joint Preservation and Deformity Correction, Paradise Valley Hospital, San Diego, CA, USA; and Hip Preservation, Tricity Medical Center, San Diego, CA, USA One of the authors certifies that he (RK) has received or may receive payments or benefits, during the study period, an amount of less than USD 10,000 from Corin (Cirencester, UK).

Background: Rowing exposes the femoral head and acetabulum to high levels of repetitive abutment motion and axial loading that may put elite athletes at an increased risk for developing early hip osteoarthritis.

Questions/purposes: Do elite rowers demonstrate characteristic hip cartilage lesions on T2 MRI sequences compared with asymptomatic individuals who do not row?

Methods: This study included 20 asymptomatic rowers (mean age, 23 ± 3 years; nine females, 11 males) who had a minimum of 5 years of intensive (≥ 12 hours/week) training. The recruiting of the rowers took place from the central German federal rowing base, which has inherent intense training and selection requirements to declare these athletes as "elite rowers. Read More

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November 2018

The Effect of Prosthetic Design and Polyethylene Type on the Risk of Revision for Infection in Total Knee Replacement: An Analysis of 336,997 Prostheses from the Australian Orthopaedic Association National Joint Replacement Registry.

J Bone Joint Surg Am 2018 Dec;100(23):2033-2040

Australian Orthopaedic Association National Joint Replacement Registry, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

Background: Periprosthetic infection following total knee replacement remains alarmingly frequent, is devastating for patients, and is an increasingly substantial public health burden. While both the prosthetic design elements and type of polyethylene used in total knee replacement can independently affect survivorship of the prosthesis, their influence on the risk of revision for infection is unknown. Therefore, we examined the effects of total knee prosthetic design and type of polyethylene bearing on the long-term revision risk for nonacute infection following total knee replacement by comparing 4 different cohorts: patients who had minimally stabilized total knee prostheses with crosslinked polyethylene (XLPE) bearing surfaces, minimally stabilized total knee prostheses with noncrosslinked polyethylene (NXLPE), posterior stabilized total knee prostheses with XLPE, and posterior stabilized total knee prostheses with NXLPE. Read More

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December 2018

HDAC10 upregulation contributes to interleukin 1β-mediated inflammatory activation of synovium-derived mesenchymal stem cells in temporomandibular joint.

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Oral and Maxillofacial Surgery, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.

Histone deacetylases (HDACs) are important in chronic inflammation, and inflammatory responses affect synovium-derived mesenchymal stem cell (SMSC) function in temporomandibular joint repair. However, the effect of HDACs on SMSC inflammatory activation remains unclear. In this study, temporomandibular joint fibroblast-like synoviocytes obtained from osteoarthritis patients met the minimal mesenchymal stem cell criteria. Read More

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December 2018

Use of a Biomimetic Scaffold for the Treatment of Osteochondral Lesions in Early Osteoarthritis.

Biomed Res Int 2018 1;2018:7937089. Epub 2018 Nov 1.

Department of Orthopaedics, Ospedale IRCCS, Sacro Cuore-Don Calabria, Negrar, Verona, Italy.

The aim of this study is to investigate clinical and radiographic outcomes of a biomimetic scaffold for the treatment of osteochondral knee lesions in patients with early OA. Study population was represented by 26 patients with a mean age of 44 years affected by early OA. Inclusion criteria were two episodes of knee pain for more than 10 days in the last year, Kellgren-Lawrence OA grade 0 or I or II, and arthroscopic findings of cartilage defects. Read More

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November 2018