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Arch Phys Med Rehabil 2019 Apr 17. Epub 2019 Apr 17.

Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China. Electronic address:

Objective: This study systematically reviews previous work on the effects of whole body vibration exercise (WBVE) on pain associated with chronic musculoskeletal disorders.
 DATA SOURCES: Seven electronic databases (PubMed, Embase, CINAHL, Web of Science, Cochrane, Physiotherapy Evidence and CNKI) were searched for articles published between January 1980 and September 2018.
 STUDY SELECTION: Randomized control trials involving adults with chronic low back pain (CLBP), osteoarthritis (OA) or fibromyalgia were included. Read More

Eur J Pain 2019 Apr 20. Epub 2019 Apr 20.

Department of Rehabilitation, Kochi Medical School, Kochi University, Nankoku, Japan.

Background: Splinting is a quite common intervention for the first carpometacarpal (CMC) osteoarthritis, however, underlying mechanisms of biomechanical and analgesic effects has not been fully investigated. The aim of this study was to develop an experimental basal thumb pain model and to elucidate the effects of CMC splinting on the pain profile and motor function.

Methods: In 14 healthy subjects, experimental basal thumb pain was induced by hypertonic saline injection into the dorsal radial ligament located on base of the first metacarpal bone. Read More

CNS Drugs 2019 Apr 19. Epub 2019 Apr 19.

Department of Medical Pharmacology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.

Tramadol-an atypical opioid analgesic-has a unique pharmacokinetic and pharmacodynamic profile, with opioidergic, noradrenergic, and serotonergic actions. Tramadol has long been used as a well-tolerated alternative to other drugs in moderate pain because of its opioidergic and monoaminergic activities. However, cumulative evidence has been gathered over the last few years that supports other likely mechanisms and uses of tramadol in pain management. Read More

J Biomech 2019 Mar 28. Epub 2019 Mar 28.

DOD-VA Extremity Trauma and Amputation Center of Excellence, Naval Medical Center San Diego, CA, USA.

Quantifying the complex loads at the patellofemoral joint (PFJ) is vital to understanding the development of PFJ pain and osteoarthritis. Discrete element analysis (DEA) is a computationally efficient method to estimate cartilage contact stresses with potential application at the PFJ to better understand PFJ mechanics. The current study validated a DEA modeling framework driven by PFJ kinematics to predict experimentally-measured PFJ contact stress distributions. Read More

Complement Ther Clin Pract 2019 May 6;35:219-223. Epub 2019 Mar 6.

Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), University of Technology Sydney, Sydney, Australia; Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.

Background And Purpose: Yoga and meditation are predominantly utilised by healthy well-educated young women, but little is known about utilisation by older chronically ill women. Therefore, the purpose of this study was to investigate the characteristics of yoga and meditation use among middle-to-higher aged Australian women with chronic conditions.

Materials And Methods: This is a sub-study of the 45 and Up Study including 1925 Australian women aged 53-95 years diagnosed with chronic conditions (asthma, depression, diabetes, osteoarthritis, and osteoporosis). Read More

Complement Ther Clin Pract 2019 May 4;35:121-125. Epub 2019 Feb 4.

Department of Joint Surgery, Affiliated Hospital of Jining Medical University, Jining, 272029, Shandong, PR China. Electronic address:

Background And Purpose: Postoperative rehabilitation plays an indispensable role for a successful total knee arthroplasty (TKA) and the optimal exercises programs are not known. A single-centre, single-blind, randomised controlled trial was designed to explore whether tai chi chuan (TCC) exercises can improve the functional outcomes and the quality of life (QOL) in patients with primary TKA due to knee osteoarthritis (OA).

Materials And Methods: One hundred seven participants with primary TKA for end-stage knee OA were enrolled from January 2014 to January 2017. Read More

Am J Phys Med Rehabil 2019 May;98(5):416-421

From the Physical Medicine and Rehabilitation Department, MossRehab, Elkins Park, Pennsylvania (BC); and Physical Medicine, Rehabilitation and Sports Medicine Department, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico (FS, WM).

Osteoarthritis is an age-related condition that commonly affects the middle-aged and elderly population including individuals who continue to pursue an active and athletic lifestyle. Running is an easily accessible activity with many health benefits; thus, it is becoming a popular form of exercise, even in older individuals. Studies evaluating the correlation between running and osteoarthritis show conflicting results; however, most studies show an increased risk of osteoarthritis in runners with a combination of modifiable and nonmodifiable risk factors. Read More

Gait Posture 2019 Apr 6;71:20-25. Epub 2019 Apr 6.

Clinic for Orthopedics and Trauma Surgery, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany. Electronic address:

Purpose: The purpose of this study was to examine how total shoulder arthroplasty improves performance of activities of daily living compared to patients with glenohumeral osteoarthritis and how they perform compared to healthy controls.

Methods: Glenohumeral and humerothoracical elevation used by patients with primary osteoarthritis (12 participants, 16 shoulders), after total shoulder arthroplasty (16 participants, 24 shoulders) and healthy controls (11 participants, 22 shoulders) for four different activities of daily living were assessed using 3D motion analysis. Analysis of range of motion and angle time series was performed. Read More

Pharmacol Rep 2019 Jan 15;71(3):399-408. Epub 2019 Jan 15.

Department of Pharmaceutical Sciences, Drug Discovery Research Laboratorty, Assam University, Silchar, Assam, India. Electronic address:

Discoidin domain receptor2 (DDR2), a cell membrane tyrosine kinase on chondrocytes surface plays main role in cell-ECM interaction during the progressive degeneration of articular cartilage in osteoarthritis. The degraded component of ECM, type II collagen upon DDR2 binding provokes synthesis of matrix metalloproteinases (MMPs), responsible for severe destruction of joint tissues. DDR2 knockout has been investigated to decline the expression of MMP-1 and 13. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 11;218:243-247. Epub 2019 Apr 11.

Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China. Electronic address:

Osteoarthritis (OA) is not only related to the degradation of articular cartilage, but also possibly to the changes of subchondral bone. The purpose of this study was to assess whether specific differences could be resolved from bone composition, as also contributed to OA. These differences were assessed by using Fourier transform infrared spectroscopy (FTIRS). Read More

Osteoarthritis Cartilage 2019 Apr 16. Epub 2019 Apr 16.

Department of Health Sciences, Lund University, Lund, Sweden; The PRO-CARE Group, School of Health and Society, Kristianstad University, Kristianstad, Sweden.

Objective: To explore, using a qualitative approach, reasons for patients' continued willingness or their shift in willingness for total joint replacement (TJR) surgery, following participation in Joint Academy, a Swedish, digital, non-surgical treatment program for osteoarthritis (OA).

Design: Nineteen patients with hip or knee OA were interviewed after finishing their first six weeks in the treatment program, using a semi-structured interview guide. The interviews were transcribed verbatim and analyzed using a systematic text condensation method. Read More

Osteoarthritis Cartilage 2019 Apr 16. Epub 2019 Apr 16.

AO Research Institute Davos, Switzerland. Electronic address:

Objective: This study aimed to characterize the mesenchymal stem cell (MSC) subpopulation migrating towards a degenerated intervertebral disc (IVD) and to assess its regenerative potential.

Design: Based on initial screening for migration towards chemokine ligand 5 (CCL5), the migration potential of CD146+ and CD146- MSCs was evaluated in vitro and in a degenerated organ culture model (degeneration by high-frequency loading in a bioreactor). Discogenic differentiation potential of CD146+ and CD146- MSCs was investigated by in vitro pellet culture assay with supplementation of growth and differentiation factor-6 (GDF6). Read More

Osteoarthritis Cartilage 2019 Apr 16. Epub 2019 Apr 16.

Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

Objective: Knee osteoarthritis (KOA) is a heterogeneous condition representing a variety of potentially distinct phenotypes. The purpose of this study was to apply innovative machine learning approaches to KOA phenotyping in order to define progression phenotypes that are potentially more responsive to interventions.

Design: We used publicly available data from the FNIH OA Biomarkers Consortium, where radiographic (medial joint space narrowing of ≥0. Read More

Osteoarthritis Cartilage 2019 Apr 16. Epub 2019 Apr 16.

St. Louis University - Neurosurgery Department - St. Louis/MO - USA.

PLoS One 2019 19;14(4):e0215812. Epub 2019 Apr 19.

Department of Anesthesiology, Cathay General Hospital, Taipei, Taiwan.

Osteoarthritis (OA) is a multifactorial joint disease and a common disabling condition in the elderly population. The associated pain and pathohistological changes in cartilage are common features of OA in both humans and animal models. Shea nut oil extract (SheaFlex75) contains a high triterpenoid concentration and has demonstrated anti-inflammatory and antiarthritic effects in both human and animal studies. Read More

J Equine Vet Sci 2019 Apr 8;75:30-34. Epub 2019 Jan 8.

Equine Clinic, Free University of Berlin, Berlin, Germany.

Autologous conditioned serum (ACS) is commonly used for the treatment of human and equine osteoarthritis (OA). The objective of this study was to investigate the influence of incubation time and incubation tube on concentrations of interleukin-1 receptor antagonist (IL-1ra), interleukin-1 beta (IL-1β), and insulin-like growth factor-1 (IGF-1) in ACS of horses with and without OA. Blood samples of 7 control horses and 6 horses with naturally occurring OA were obtained. Read More

Int Orthop 2019 Apr 19. Epub 2019 Apr 19.

ARCUS Sportklinik, Rastatter Str. 17-19, 75179, Pforzheim, Germany.

Background: Femoro-acetabular impingement (FAI) is known as a predisposing factor in the development of osteoarthritis of the hip. In order to treat this condition, hip arthroscopy is considered as the gold standard in recent years. The number of performed hip arthroscopies has risen immensely. Read More

Malays Orthop J 2019 Mar;13(1):42-44

Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore.

We present a unique case of tibial post fracture of a posterior-stabilised total knee arthroplasty (PS-TKA) using highly crosslinked polyethylene (HXLPE) in the unafflicted limb of a patient who had poliomyelitis. The tibial post is an upright structure perpendicular to the PE insert articular surface which articulates with the cam of the femoral component to prevent excessive posterior translation of the tibia. We explore the choice of PS polyethylene (PE) inserts in patients with neuromuscular disorders (NMD). Read More

Malays Orthop J 2019 Mar;13(1):8-13

Department of Orthopaedics, Chulalongkorn University, Bangkok, Thailand.

Anterior cruciate ligament (ACL) tear is the most common knee ligament injury, especially in athletes. The objective of this study was to investigate relative telomere length (RTL) in blood leukocytes of patients with ACL injury compared with that of controls. A total of 187 subjects were invited to participate in this study. Read More

Malays Orthop J 2019 Mar;13(1):1-7

Swansea University Medical School, Swansea University, Swansea, United Kingdom.

The role of extracellular vesicles (EV) in osteoarthritis has become the focus of much research. These vesicles were isolated from several cell types found in synovial joint including chondrocytes and synovium. As articular cartilage is an avascular tissue surrounded by synovial fluid, it is believed that EV might play a crucial role in the homeostasis of cartilage and also could hold key information in the pathogenesis of osteoarthritis. Read More

Evid Based Complement Alternat Med 2019 14;2019:1291947. Epub 2019 Mar 14.

School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Objective: The aim of this study was to investigate the difference of efficacy between conventional moxibustion (CM) and smoke-free moxibustion (SM) for patients with osteoarthritis of the knee (KOA).

Methods: This is a multicentre, randomized, single blinded, parallel-group clinical trial. Patients with KOA were randomly allocated to CM group (69) and SM group (69) in 7 hospitals of China. Read More

J Arthroplasty 2019 Mar 29. Epub 2019 Mar 29.

Department of Osteoarthritis and Sport Surgery, Traumatology of the Limbs, Grenoble-Alpes South Teaching Hospital, Echirolles, France.

Background: The present study was designed to evaluate the risk of significant polyethylene (PE) wear 10 years or more after implantation of a total knee arthroplasty (TKA) using electron beam-irradiated highly cross-linked PE component.

Methods: All patients operated between 2001 and 2004 for implantation of this particular TKA in the two participating centers were eligible for this study. All patients were contacted after the 10-year follow-up for repeat clinical examination and radiological evaluation. Read More

Arthroscopy 2019 Apr 15. Epub 2019 Apr 15.

Department of Orthopedics, Rush University Medical Center, Chicago, Illinois, U.S.A.. Electronic address:

Purpose: The purpose of this study was to establish minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient-acceptable symptom state (PASS) after meniscectomy and factors associated with achieving these goals.

Methods: A prospectively maintained institutional registry was retrospectively reviewed for all patients undergoing isolated arthroscopic partial meniscectomy from 2014 through 2017. MCID, SCB, and PASS were calculated for the International Knee Documentation Committee (IKDC) and Knee Injury and Osteoarthritis Outcome Score (KOOS) subscores by using the anchor-based methodology and nonparametric receiver operating characteristic curves. Read More

Clin Orthop Relat Res 2019 May;477(5):1036-1052

F. Schmaranzer, R. Helfenstein, T. D. Lerch, K. A. Siebenrock, M. Tannast, Department of Orthopaedic Surgery, Inselspital Bern, University of Bern, Switzerland, Bern, Switzerland G. Zeng, G. Zheng, Institute for Surgical Technology and Biomechanics, University of Bern, Switzerland, Bern, Switzerland F. Schmaranzer, E. N. Novais, J. D. Wylie, Y-J. Kim, Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Background: The time-consuming and user-dependent postprocessing of biochemical cartilage MRI has limited the use of delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). An automated analysis of biochemical three-dimensional (3-D) images could deliver a more time-efficient and objective evaluation of cartilage composition, and provide comprehensive information about cartilage thickness, surface area, and volume compared with manual two-dimensional (2-D) analysis.

Questions/purposes: (1) How does the 3-D analysis of cartilage thickness and dGEMRIC index using both a manual and a new automated method compare with the manual 2-D analysis (gold standard)? (2) How does the manual 3-D analysis of regional patterns of dGEMRIC index, cartilage thickness, surface area and volume compare with a new automatic method? (3) What is the interobserver reliability and intraobserver reproducibility of software-assisted manual 3-D and automated 3-D analysis of dGEMRIC indices, thickness, surface, and volume for two readers on two time points?

Methods: In this IRB-approved, retrospective, diagnostic study, we identified the first 25 symptomatic hips (23 patients) who underwent a contrast-enhanced MRI at 3T including a 3-D dGEMRIC sequence for intraarticular pathology assessment due to structural hip deformities. Read More

Acta Orthop 2019 Apr 18:1-10. Epub 2019 Apr 18.

c Swedish Hip Arthroplasty Register , Gothenburg ;

Background and purpose - The theoretical mechanical advantages of metal-on-metal hip resurfacing (MoM-HR) compared with conventional total hip arthroplasty (THA) have been questioned. Studies including measures of patient-reported function, physical activity, or health-related quality of life have been sparse. We compared patient-reported outcomes in MoM-HR patients with a matched group of patients with conventional THA at 7 years post-surgery. Read More

RMD Open 2019 8;5(1):e000795. Epub 2019 Mar 8.

Scienze Cliniche e Biologiche, Università degli Studi di Torino, Rome, Italy.

Objective: To evaluate the level of agreement on ultrasonographic (US) lesions among highly experienced sonographers as well as the intraobserver and interobserver reliability of inflammatory and structural US lesions in patients with osteoarthritis (OA) of the foot.

Methods: After a systematic literature review, a Delphi survey was performed to test definitions of US lesions in OA of the foot, including inflammatory lesions (ie, synovial hypertrophy [SH], joint effusion [JE], power Doppler signal [PD]), and structural abnormalities (ie, cartilage damage [CD] and osteophytes). Subsequently, the reliability of US in assessing the aforementioned lesions was tested on static images as well as during a live exercise. Read More

Pilot Feasibility Stud 2019 6;5:54. Epub 2019 Apr 6.

1School of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, B15 2TT UK.

Background: Osteoarthritis is a highly prevalent condition in older adults, that causes many sufferers to require a hip or knee replacement in order to improve their quality of life and reduce pain. Individuals waiting for hip or knee replacements are often highly sedentary; thus, it is pertinent to assess whether reducing their sedentariness prior to surgery may aid in improving post-operative outcomes.

Methods/design: The study will be a randomised controlled feasibility trial design, with 2:1 randomisation into an intervention and usual care group respectively. Read More

Bone Joint Res 2019 Mar 2;8(3):156-164. Epub 2019 Apr 2.

Department of Mechanical Engineering, Department of Mechanical Engineering, Yonsei University, Seoul, South Korea.

Objectives: Unicompartmental knee arthroplasty (UKA) is an alternative to total knee arthroplasty for patients who require treatment of single-compartment osteoarthritis, especially for young patients. To satisfy this requirement, new patient-specific prosthetic designs have been introduced. The patient-specific UKA is designed on the basis of data from preoperative medical images. Read More

Bone Joint Res 2019 Mar 2;8(3):126-135. Epub 2019 Apr 2.

Department of Orthopedic Surgery, Kyoto University, Graduate School of Medicine, Kyoto, Japan.

Objectives: Unicompartmental knee arthroplasty (UKA) is one surgical option for treating symptomatic medial osteoarthritis. Clinical studies have shown the functional benefits of UKA; however, the optimal alignment of the tibial component is still debated. The purpose of this study was to evaluate the effects of tibial coronal and sagittal plane alignment in UKA on knee kinematics and cruciate ligament tension, using a musculoskeletal computer simulation. Read More

J Orthop 2019 Jul-Aug;16(4):342-346. Epub 2019 Mar 24.

Department of Orthopedics Tergooiziekenhuizen, Van Riebeeckweg 212, 1213, XZ, Hilversum, the Netherlands.

Background: Purpose of this study was to evaluate the long - term survivorship and clinical and radiological results of a primary reverse total shoulder arthroplasty (RTSA) performed with uncemented stems.

Methods: From 2001 until 2006 61 primary uncemented RTSAs were implanted, which were included in a Kaplan-Meier survival analysis. Range of motion, functional scores and radiological follow - up was obtained. Read More

J Orthop 2019 Jul-Aug;16(4):334-336. Epub 2019 Mar 26.

Department of Orthopaedic Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Purpose: We compared the outcome of total hip arthroplasty (THA) in this age group using direct anterior or posterior approach.

Methods: We performed a retrospective analysis following consecutive primary THA in patients over 80 years.

Results: The DAA group demonstrated significantly shorter length of stay, better functional improvement, no dislocation or revision while PA group required two revisions due to dislocation. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):268-272

Department of Orthopaedics, Guizhou Provincial people's Hospital, Guiyang 550002, China.

Objective: To evaluate the early clinical effects of direct anterior approach (DAA) versus anterolateral approach (ALA) on safety and functional recovery following total hip arthroplasty (THA).

Methods: Between January 2015 and May 2016, a randomized clinical trial was performed at Guizhou Provincial People's Hospital. A total of 50 patients who underwent THA were allocated for either the DAA (n=25) or ALA (n=25). Read More

Biosci Rep 2019 Apr 17. Epub 2019 Apr 17.

Xiangya Hospital, Central South University, Changsha, China.

Osteoarthitis (OA) is the most common aging-related joint pathology; the aging process results in changes to joint tissues that ultimately contribute to the development of OA. Articular chondrocytes exhibit an aging-related decline in their proliferative and synthetic capacity. Sirtuin 1 (SIRT 1), a longevity gene related to many diseases associated with aging, is a NAD+-dependent protein deacetylase and master metabolic regulator. Read More

Osteoarthritis Cartilage 2019 Apr 14. Epub 2019 Apr 14.

Clinical Epidemiology, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, UK. Electronic address:

Objective: To determine the natural history of flare-ups in knee osteoarthritis and their relation to physical exposures.

Design: Adults aged ≥45 years with a recent primary care consultation for knee OA/arthralgia completed a daily pen-and-paper diary for up to 3 months, including questions on average knee pain intensity, pain descriptors, other symptoms, activity interference, and selected physical exposures (prolonged kneeling, squatting, climbing stairs, ladders, and moving/lifting heavy objects). Informed by a systematic review, flare-ups were defined a priori. Read More

Toxicon 2019 Apr 14. Epub 2019 Apr 14.

Aja University of Medical Sciences, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Islamic Republic of Iran. Electronic address:

In recent years, there is a growing interest in new medical applications of botulinum toxin, including pain control, osteoarthritis treatment, and wound healing. While clinical applications of botulinum toxin seem promising, existing evidence regarding the therapeutic effects is still inadequate. The aim was to assess the efficacy of a single injection of abobotulinumtoxin A into the knee joint cavity to reduce pain in elderly people. Read More

Agri 2019 Apr;31(2):63-69

Department of Biochemistry, Istanbul Silivri Medicalpark Hospital, Istanbul, Turkey.

Objectives: The administration of platelet-rich plasma (PRP), which increases the release of growth factors targeting cartilage regeneration, is used in an effort to relieve pain in knee osteoarthritis (OA). This study measured the short-term efficacy of PRP on chronic pain in patients with OA of the knee.

Methods: Patients with chronic knee pain and grade 2-4 knee OA based on the Kellgren-Lawrence (K-L) classification were enrolled in the study. Read More

J Athl Train 2019 Apr 17. Epub 2019 Apr 17.

Integrated Sports Science Research Laboratory, Yonsei University, Seoul, Republic of Korea.

Objective: To describe the effects of proprioceptive training on pain, stiffness, function, and functional test outcomes among patients with knee osteoarthritis (OA).

Data Sources: All studies completed from 1946 to 2017 were obtained from 4 databases (PubMed, MEDLINE, CINAHL, and SPORTDiscus).

Study Selection: Three reviewers independently identified appropriate studies and extracted data. Read More

Acta Orthop 2019 Apr 17:1-9. Epub 2019 Apr 17.

b The Swedish Knee Arthroplasty Register , Lund , Sweden.

Background and purpose - Patient-reported outcome (PRO) in total knee arthroplasty (TKA) patients with high body mass index (BMI) is controversial. We compared pain, function, quality of life, general health, and satisfaction among different BMI categories preoperatively and 1 year after primary TKA. Patients and methods - 4,318 patients were operated with a TKA for knee osteoarthritis in the Region of Skane in 2013-2015. Read More

Acta Orthop 2019 Apr 17:1-9. Epub 2019 Apr 17.

a Department of Orthopaedics, Institute of Clinical Sciences , Sahlgrenska Academy, University of Gothenburg , Gothenburg ;

Background and purpose - It is unclear whether physiotherapy interventions or patient education before total hip replacement (THR) is beneficial for patients postoperatively. Utilizing the Swedish Hip Arthroplasty Register (SHAR), we retrospectively studied the influence of preoperative self-reported exposure to physiotherapy and/or patient education on patient-reported outcomes 1 year after THR. Patients and methods - Data covering all THRs performed in Sweden for osteoarthritis, between the years 2012 and 2015, was obtained from SHAR. Read More

Intern Med J 2019 Apr 16. Epub 2019 Apr 16.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.

Background: Knee osteoarthritis (OA) is one of the most common joint diseases, and pharmacotherapy is necessary to control its symptoms.

Aim: To evaluate efficacy and tolerability of duloxetine in patients with knee OA.

Methods: PubMed, Web of Science, Embase, Cochrane Library, and ClinicalTrials. Read More

Aging Clin Exp Res 2019 Apr 16. Epub 2019 Apr 16.

WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Liège, Belgium.

There is increasing emphasis on patient-centred research to support the development, approval and reimbursement of health interventions that best meet patients' needs. However, there is currently little guidance on how meaningful patient engagement may be achieved. An expert working group, representing a wide range of stakeholders and disciplines, was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the World Health Organization (WHO). Read More

Biomech Model Mechanobiol 2019 Apr 16. Epub 2019 Apr 16.

Faculty of Kinesiology, University of Calgary, 2500 University Dr. NW, Calgary, T2N 1N4, Canada.

Macro-cracks on the surface of articular cartilage are one of the hallmarks of early osteoarthritis and joint damage initiation. Macro-cracks negatively affect cartilage mechanobiology and load bearing capacity. The aim of this study was to quantify the changes in transient and steady-state force response of healthy cartilage in the presence of macro-cracks when compressed. Read More

Biomed Res Int 2019 12;2019:1434538. Epub 2019 Mar 12.

Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.

Osteoarthritis (OA) is a chronic degenerative joint disease, where chondrocyte apoptosis is responsible for cartilage degeneration. Bax is a well-known proapoptotic protein of the Bcl-2 family, involved in a large number of physiological and pathological processes. However, the regulation mechanisms of Bax underlying chondrocyte apoptosis in OA remain unknown. Read More

EFORT Open Rev 2019 Mar 8;4(3):70-76. Epub 2019 Mar 8.

Department of Biomedical Engineering, University of Strathclyde, Glasgow, UK.

Patient-reported instability is a common complaint amongst those with knee arthritis.Much research has examined the assessment of self-reported instability in the knee; however, no definitive quantitative measure of instability has been developed.This review focuses on the current literature investigating the nature of self-reported instability in the arthritic knee and discusses the possibilities of further investigation. Read More

J Arthroplasty 2019 Mar 28. Epub 2019 Mar 28.

Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Background: The objective of this study is to investigate whether central sensitization (CS) was associated with patient dissatisfaction after revision total knee arthroplasty (TKA).

Methods: Between 2012 and 2016, 68 cases (68 patients) of revision TKA performed by a single surgeon were included in this study with a minimum follow-up of 2 years. Patients were categorized into 2 groups by 40-point preoperative Central Sensitization Inventory (CSI) scores. Read More

Foot Ankle Surg 2019 Apr 1. Epub 2019 Apr 1.

Division of Radiology, Department of Imaging and Medical Informatics, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland. Electronic address:

Background: Syndesmosis injury can lead to ankle mortise instability and early osteoarthritis. Several multiple detector computed tomography (MDCT) methods for measurement have been developed. Weight-bearing cone beam CT (WB CBCT) is an emerging technique that offers the possibility of upright-position scanning and lower doses. Read More

BMC Musculoskelet Disord 2019 Apr 16;20(1):172. Epub 2019 Apr 16.

Traumatology and Orthopedic Surgery Department, Hospital Universitario Santa Cristina, Calle del Maestro Vives 2 y 3, Madrid, Spain.

Background: Hip resurfacing arthroplasty (HRA) and in particular, Birmingham hip resurfacing (BHR), is commonly employed as an alternative to total hip arthroplasty (THA) in young patients, as it allows for preservation of femoral bone stock and resumption of physical activity. The aim of our study was to investigate 5-year survival and functional outcomes of BHR arthroplasty in young Spanish osteoarthritis (OA) patients.

Methods: This is an observational, prospective, cohort study of patients who underwent BHR between June 2005 and December 2009 at a Spanish public hospital with a minimum follow-up of 5 years. Read More

FASEB J 2019 Apr 16:fj201802281R. Epub 2019 Apr 16.

Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.

Periostin (), a secretory matricellular matrix protein, plays a multitude of biologic functions. Various splice variants of have been described; however, their expression pattern and functional implications are not completely understood. This study was undertaken to decipher the differential expression pattern of and its splice variants in various tissues and cell types. Read More

J Affect Disord 2019 Apr 8;252:294-299. Epub 2019 Apr 8.

University of Technology Sydney, Faculty of Health, PO Box 123 Broadway NSW 2007, Ultimo, NSW, Australia.

Background: The aim of this study was to determine the impact of physical activity on depression symptom severity in women 45 years and older with a chronic illness diagnosis, and explore relations between physical activity and psychological and health-related characteristics predicting depression symptoms.

Methods: 1932 women diagnosed with one of five chronic illnesses: asthma, depression, diabetes, osteoarthritis, or osteoporosis participated in a sub-study of the 45 and Up Study-a cross-sectional study of people aged 45 years and older. The survey included items measuring demographics, depression symptoms, health-related quality of life (HRQoL), health-related hardiness, sleep quality, and health behaviours, such as physical activity. Read More

Osteoarthritis Cartilage 2019 Apr 13. Epub 2019 Apr 13.

Department of Orthopaedic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Musculoskeletal Research Unit (MSRU), Equine Hospital, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland; Department of Orthopaedic Surgery and Traumatologie, Cantonal Hospital, University of Fribourg, Switzerland.

Objective: In ovine hips chondrolabral damage as seen in cam-type femoroacetabular impingement (FAI) can be induced via an intertrochanteric varus osteotomy. However, it is yet to proven whether the observed cartilage damage is caused by a dynamic cam type impingement. Thus we asked, (1) whether actual cartilage damage observed after FAI induction in ovine hips occurs at the predicted, computed zone of FAI; (2) whether the extent of cartilage damage increases with ambulation time in this animal model?

Design: In this experimental, controlled, comparative study 20 sheep underwent unilateral FAI induction through an intertrochanteric varus osteotomy. Read More