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Gait Posture 2020 Jun 27;81:21-26. Epub 2020 Jun 27.

Motion Analysis and Biofeedback Laboratory, University of British Columbia, 212 - 2177 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada; Department of Physical Therapy, University of British Columbia, 212 - 2177 Wesbrook Mall, Vancouver, BC, V6T 1Z3. Electronic address:

Background: Novel designs of lateral wedge insoles with arch support can alter walking biomechanics as a conservative treatment option for knee osteoarthritis. However, variations in foot posture may influence individual responses to insole intervention and these effects are not yet known.

Research Question: How does foot posture influence biomechanical responses to novel designs of lateral wedge insoles with arch support?

Methods: This exploratory biomechanical investigation categorized forty healthy volunteers (age 23-34) into pronated (n = 16), neutral (n = 15), and supinated (n = 9) foot posture groups based on the Foot Posture Index. Read More

PLoS One 2020 10;15(7):e0235658. Epub 2020 Jul 10.

CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.

Medical diagnostic X-rays are an important source of ionizing radiation (IR) exposure in the general population; however, it is unclear if the resulting low patient doses increase lymphoma risk. We examined the association between lifetime medical diagnostic X-ray dose and lymphoma risk, taking into account potential confounding factors, including medical history. The international Epilymph study (conducted in the Czech-Republic, France, Germany, Ireland, Italy, and Spain) collected self-reported information on common diagnostic X-ray procedures from 2,362 lymphoma cases and 2,465 frequency-matched (age, sex, country) controls. Read More

Addiction 2020 Jul 10. Epub 2020 Jul 10.

Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, Florida, USA.

Background And Aims: Little is known about opioid and gabapentinoid (OPI-GABA) use duration and dose patterns' associations with adverse outcomes risks. We examined associations between OPI-GABA dose and duration trajectories and subsequent drug overdose.

Design: Retrospective cohort study. Read More

Foot Ankle Int 2020 Jul 10:1071100720933891. Epub 2020 Jul 10.

Department of Orthopedics and Rehabilitation, University of Iowa, Iowa City, IA, USA.

Background: Posttraumatic osteoarthritis (PTOA) of the subtalar joint is a serious, disabling, and frequent complication following intra-articular calcaneal fractures (IACFs). Using plain radiographs to assess the subtalar joint for PTOA is imprecise and insensitive, hindering progress toward improving treatment and assessing outcomes. This study explored how low-dose weightbearing computed tomography (WBCT) can be used to provide reliable, quantitative 3D measures of subtalar joint space width (JSW) following IACF and correlated the 3D JSW with clinical outcomes. Read More

Nutr Cancer 2020 Jul 10:1-12. Epub 2020 Jul 10.

Department of Clinical Nutrition and Dietetic, National Institute and Faculty of Nutrition and Food Technology, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

This systematic review assesses the literature regarding beneficial and potential detrimental effects of bioactive peptides (BPs), focusing on evidence of regulatory T cells (T-regs) mediated oral tolerance (OT), collagen hydrolysate (CH) supplementation in osteoarthritis (OA) and the association of T-regs with chronic disease. The systematic search was done for articles published from inception to April 2019 using the PubMed and Scopus databases. About 3081 papers were identified by three different search strategies and screened against inclusion criteria which resulted in the inclusion of 22 articles. Read More

Health Expect 2020 Jul 9. Epub 2020 Jul 9.

Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, Southmead Hospital, University of Bristol, Bristol, UK.

Background: Although many people are satisfied with their outcome after total knee replacement surgery for osteoarthritis, around 20% report chronic post-surgical pain. People are often disappointed and unsure about whether their pain is normal and what can be done about it. Given the high prevalence of long-term post-operative pain after knee replacement, there is potentially a large hidden population with an unaddressed need for care. Read More

Ann Biomed Eng 2020 Jul 9. Epub 2020 Jul 9.

Department of Applied Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland.

Relationships between composition, structure and constituent-specific functional properties of human articular cartilage at different stages of osteoarthritis (OA) are poorly known. We established these relationships by comparison of elastic, viscoelastic and fibril-reinforced poroelastic mechanical properties with microscopic and spectroscopic analysis of structure and composition of healthy and osteoarthritic human tibial cartilage (n = 27). At a low frequency (0. Read More

Int Orthop 2020 Jul 9. Epub 2020 Jul 9.

Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Purpose: To evaluate the evidence supporting safety and effectiveness of intra-articular injective treatments for ankle lesions ranging from osteochondral lesions of the talus (OLT) to osteoarthritis (OA).

Methods: A systematic review and a meta-analysis were performed on PubMed, Embase, and Cochrane Library in March 2020. Safety was evaluated through the reported side effects and effectiveness through the scores used. Read More

Int Orthop 2020 Jul 9. Epub 2020 Jul 9.

Sección de Hombro y Codo, Servicio de Cirugía de la Mano y miembro superior, Departamento de Ortopedia y Traumatología, Hospital Militar Central. Cirujano Mayor Cosme Argerich, Luis Maria Campos Av. 726 piso 6, C1426BOS, Buenos Aires City, Argentina.

Purpose: To report radiologic, functional outcomes, and complications with a long-term follow-up in acute olecranon fractures treated with osteosynthesis and, secondly, to determine the predisposing factors to arthritis.

Methods: Forty-two patients treated with osteosynthesis for acute olecranon fractures were reviewed, with a minimum follow-up of 24 months. Radiological and clinical evaluations including DASH, MEPS, active range of motion, pain, arthritis, associated lesions, and complications were recorded. Read More

Lasers Med Sci 2020 Jul 10. Epub 2020 Jul 10.

Department of Physical Therapy, Faculty of Applied Medical Sciences, Umm Al-Qura University, Mecca, Saudi Arabia.

The institutional affiliation of Dr. Aly Elsayed Mohamed Elsayed should be as follow. Read More

Ann Transl Med 2020 Jun;8(12):772

Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou 510000, China.

Ann Transl Med 2020 Jun;8(12):766

Department of Miao Medicine, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, China.

Background: Osteoarthritis (OA) is the most common joint disease, affecting most middle-aged and elderly people. Astilin (AST) is the main active ingredient isolated from the traditional Chinese medicine Astilbe chinensis and has anti-inflammatory and anti-arthritis effects. The purpose of this study was to investigate the effect and mechanism of AST on OA in rats mediated by papain. Read More

J Taibah Univ Med Sci 2020 Jun 1;15(3):197-202. Epub 2020 May 1.

Medical Rehabilitation Department, Eradah Hospital for Mental Health, Jazan, KSA.

Objectives: Reduced strength and girth in thigh muscles such as the quadriceps and the hamstrings have been observed in patients with knee osteoarthritis (OA). However, studies on the characteristics of calf muscles in these patients are lacking. This study aimed to evaluate the girth, strength, and flexibility of the calf muscle of patients with knee OA. Read More

J Taibah Univ Med Sci 2020 Jun 15;15(3):190-196. Epub 2020 May 15.

Basic Science Department, Faculty of physical therapy, Cairo University, Egypt.

Objective: This study aimed to compare the effects between low- versus medium-energy radial extracorporeal shock wave therapy on knee osteoarthritis (KOA).

Method: Forty-five patients (26 women and 19 men) aged 45-55 years with grade 2 KOA were randomly assigned into the following three groups (all n = 15): Group A received low-energy radial shock wave therapy (2000 shock/session [10 Hz], energy flux density [EFD] 0.02 mJ/mm) with strengthening exercises once per week for 4 weeks; Group B received medium-energy radial shock wave therapy (2000 shock/session [10 Hz], EFD 0. Read More

Sci Rep 2020 Jul 9;10(1):11328. Epub 2020 Jul 9.

Translational Health Sciences, Bristol Medical School, Musculoskeletal Research Unit, Southmead Hospital, University of Bristol, Learning and Research Building (Level 2), Bristol, BS10 5NB, UK.

Osteoarthritis (OA) is the most common chronic degenerative joint disease which causes substantial joint pain, deformity and loss of activities of daily living. Currently, there are over 500 million OA cases worldwide, and there is an urgent need to identify biomarkers for early detection, and monitoring disease progression in patients without obvious radiographic damage to the joint. We have used regression modelling to describe the association of 19 of the currently available biomarkers (predictors) with key radiographic and clinical features of OA (outcomes) in one of the largest and best characterised OA cohort (NIH Osteoarthritis Initiative). Read More

Nat Commun 2020 Jul 9;11(1):3427. Epub 2020 Jul 9.

Department of Orthopaedic Surgery and Cell Biology & Physiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

The contribution of inflammation to the chronic joint disease osteoarthritis (OA) is unclear, and this lack of clarity is detrimental to efforts to identify therapeutic targets. Here we show that chondrocytes under inflammatory conditions undergo a metabolic shift that is regulated by NF-κB activation, leading to reprogramming of cell metabolism towards glycolysis and lactate dehydrogenase A (LDHA). Inflammation and metabolism can reciprocally modulate each other to regulate cartilage degradation. Read More

Anat Cell Biol 2020 Jun;53(2):126-131

Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

The rupture of ligament in the lateral part of ankle joint is a common injury and can lead to chronic ankle instability and lead to ankle osteoarthritis. Ankle arthroscopy is considered as a standard option to treat various ankle problems due to the need for only minimal incisions and fewer complications when compared to open surgery. However, there are complications associated with arthroscopic surgery e. Read More

RMD Open 2020 Jul;6(2)

Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Objective: Past epidemiological studies have consistently demonstrated a link between rheumatoid arthritis (RA) and the incidence of lymphoma and it has been posited that high systemic inflammatory activity is a major risk determinant of lymphomagenesis. Given advances in the therapeutic armamentarium for RA management in recent years, the resulting lower level of disease activity could have led to a decline in lymphoma incidence in patients with RA. This study examined recent trends in lymphoma incidence in US veterans with RA. Read More

Int J Orthop Trauma Nurs 2020 May 16:100789. Epub 2020 May 16.

College of Nursing, Gachon University, Incheon, South Korea. Electronic address:

Aim: The purpose of this study was to analyze the effect of an exercise programme that uses text messages on knee function after arthroscopic knee surgery.

Methods: This was a quasi-experimental study that used the nonequivalent control group non-synchronized design. A total of 52 adult patients (25 in the experimental group and 24 in the control group). Read More

J Arthroplasty 2020 Jun 18. Epub 2020 Jun 18.

Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN.

Background: Extensor mechanism (EM) disruption after total knee arthroplasty is a catastrophic complication. Reconstruction using monofilament polypropylene mesh (Marlex Mesh; CR Bard, Franklin Lakes, NJ) has emerged as the preferred treatment, but reports are limited to the designing institution. This study describes a nondesigner experience and compares 2 postoperative immobilization strategies: long leg cast vs knee immobilizer. Read More

J Arthroplasty 2020 May 26. Epub 2020 May 26.

Clinical Research Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Division of Clinical Epidemiology, Department of Health and Community Medicine, University Hospitals of Geneva, Geneva, Switzerland.

Background: Total knee arthroplasty (TKA) is the operation of choice in patients with end-stage knee osteoarthritis (OA). Up to 1 in 5 patients still encounter functional limitations after TKA, partly explaining patient dissatisfaction. Which gait ability to target after TKA remains unclear. Read More

J Arthroplasty 2020 Jun 17. Epub 2020 Jun 17.

Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.

Background: This study aimed to investigate the change in ankle varus incongruencies following total knee replacement (TKR) in patients with preoperative genu varum deformity of ≥10°.

Methods: The study cohort was composed of patients who underwent TKR in a single institution for knee osteoarthritis with preoperative genu varum deformity of ≥10° and concomitant varus ankle incongruencies. Eight radiographic measurements were evaluated preoperatively and postoperatively: mechanical tibiofemoral angle, mechanical lateral distal femoral angle, medial proximal tibial angle, lateral distal tibial angle, tibial plafond inclination, talar inclination, tibiotalar tilt angle (TTTA), and tibia-mechanical axis angle. Read More

Injury 2020 Jun 24. Epub 2020 Jun 24.

Royal Adelaide Hospital, Orthopaedic Trauma, Adelaide, Australia; The University of Adelaide, Trauma & Orthopaedics, Adelaide, Australia.

Surgical management of acetabular fractures is now commonplace for almost all displaced or unstable fractures. Over the last 20 years however, the patient population has aged, and there have been significant changes to safety in motor vehicles and the work-place, and people's activity types and levels have changed. The surgical specialty has also developed with time, and as a result acetabular fracture surgery today is different to 20 years ago. Read More

BMC Musculoskelet Disord 2020 Jul 9;21(1):447. Epub 2020 Jul 9.

Agency for Heath Quality and Assessment of Catalonia (AQuAS), Carrer de Roc Boronat, 81, 08005, Barcelona, Spain.

Background: The impact of comorbidity on the risk of revision in patients undergoing Total Knee arthroplasty (TKA) and Total Hip Arthroplasty (THA) is not currently well known. The aim of this study was to analyze the impact of comorbidity on the risk of revision in TKA and THA.

Methods: Patients recorded in the Catalan Arthroplasty Register (RACat) between 01/01/2005 and 31/12/2016 undergoing TKA (n = 49,701) and THA (n = 17,923) caused by osteoarthritis were included. Read More

Comput Methods Programs Biomed 2020 Jul 3;196:105644. Epub 2020 Jul 3.

Department of Mechanical Engineering, University of West Attica, 12210 Athens, Greece. Electronic address:

The synovial fluid is a transparent electrolyte solution included in joints to provide lubrication helping the proper movement. It exhibits complex rheological properties due to the interaction among its constituents i.e. Read More

Osteoarthritis Cartilage 2020 Jul 6. Epub 2020 Jul 6.

Department of Mechanical Engineering, University of Colorado, Boulder, CO; BioFrontiers Institute, University of Colorado, Boulder, CO; Biomedical Engineering Program, University of Colorado, Boulder, CO. Electronic address:

Objective: Quantitative, micrometer length scale assessment of human articular cartilage is essential to enable progress toward new functional tissue engineering approaches, including utilization of emerging 3D bioprinting technologies, and for improved computational modeling of the osteochondral unit. Thus the objective of this study was to characterize the structural organization, material properties, and chemical composition of human skeletally mature articular cartilage with respect to depth and defined morphological features: normal to the articulating surface, parallel to the split-line, and transverse to the split-line.

Method: Three samples from the lateral femoral condyles of 4 healthy adult donors (55-61 years old) were evaluated via histology, second harmonic generation, microindentation, and Raman spectroscopy. Read More

Eur J Rheumatol 2020 Apr 1;7(2):88-89. Epub 2020 Apr 1.

Department of Histology and Embryology, Ankara Yıldırım Beyazıt University School of Medicine, Ankara, Turkey.

Eur J Rheumatol 2020 Apr 1;7(2):84-87. Epub 2020 Apr 1.

Division of Rheumatology, Department of Internal Medicine, Ondokuz Mayıs University School of Medicine, Samsun, Turkey.

Calcium pyrophosphate deposition disease (CPPD) is a crystal arthropathy, and may present with various clinical manifestations such as asymptomatic CPPD, osteoarthritis with CPPD, acute CPPD crystal arthritis (formerly pseudogout), and chronic CPPD crystal inflammatory arthritis. It is known that aging, trauma and osteoarthritis are major risk factors for CPPD. Acute CPP arthritis may occur as monoarticular or oligoarticular and usually involves large peripheral joints such as the knees, wrists and ankles. Read More

J Comp Eff Res 2020 Jul 9. Epub 2020 Jul 9.

Health Economics & Market Access, DePuy Synthes, Raynham, MA 02767, USA.

To examine the time-to-total knee replacement (TKR) surgery among patients with high-concentration nonavian high-molecular-weight hyaluronan injection (HMW-HA) compared with those without HA injections. Using MarketScan Commercial claims all patients aged 18-64 who underwent TKR surgery between 2008 and 2017 were identified. Time-to-TKR surgery was compared between patients receiving Orthovisc (Anika Therapeutics Inc. Read More

Zhen Ci Yan Jiu 2020 Jun;45(6):490-4

Institute of Acupuncture-moxibustion and Massage of Hebei University of Traditional Chinese Medicine, Shijiazhuang 050200, China.

Objective: To investigate the application characteristics of different acupuncture-moxibusition (acu-moxi) therapies for knee osteoarthritis (KOA), and to provide a reference for clinical application.

Methods: Computer and data mining techniques were used to establish a database of acu-moxi therapies for KOA, and the articles on acu-moxi in the treatment of KOA in the past decade were collected, screened, entered, reviewed, and analyzed. Acu-moxi therapies for KOA were summarized in terms of treatment method, clinical effect, association between treatment method and acupoint selection, needle specifications, and depth of acupuncture. Read More

Zhen Ci Yan Jiu 2020 Jun;45(6):484-9

Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011.

Objective: To investigate the clinical effect of thunder-fire moxibustion combined with electroacupuncture in the treatment of cold-dampness knee osteoarthritis.

Methods: A total of 72 patients with cold-dampness knee osteoarthritis were randomly divided into observation group and control group according to the random numbers generated by computer software, with 36 patients in each group. For the observation group, electroacupuncture was performed at the main acupoints of Dubi (ST35), Neixiyan (EX-LE4), Zusanli (ST36), Yanglingquan (GB34), Yinlingquan (SP9), Xuehai (SP10), Liangqiu (ST34), and Heding (EX-LE2) once a day, with a needle retaining time of 30 min, and thunder-fire moxibustion was performed at Shenque (CV8) and Guanyuan (CV4) in the form of suspended moxibustion once a day, with 30 min each time. Read More

J Knee Surg 2020 Jul 8. Epub 2020 Jul 8.

Department of Orthopedic Surgery, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.

The aim of this study was to verify the single-factor structure of the joint replacement version of the Knee Injury and Osteoarthritis Outcome Score (KOOS-JR) and examine its measurement properties in the context of Rasch analysis in patients with end-stage osteoarthritis of the knee (KOA) awaiting total knee replacement (TKR). The study design was retrieval of prospectively collected clinical data. The data were extracted from the presurgery visit for individuals with KOA who were scheduled for primary TKR at a tertiary care hospital. Read More

Med Sci Monit 2020 Jul 9;26:e923868. Epub 2020 Jul 9.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, China (mainland).

BACKGROUND Growing evidence suggests that long non-coding RNAs (lncRNAs), as decoys of microRNAs (miRNAs), are involved in osteoarthritis (OA) progression, but the potential mechanism of lncRNA SNHG15 in OA remains unknown. Thus, the present study explored the molecular mechanism of SNHG15 in OA progression. MATERIAL AND METHODS OA chondrocytes were created by 20 ng/ml IL-1ß stimulation, and the experimental OA model was created by destabilization of the medial meniscus (DMM) surgery. Read More

J Shoulder Elbow Surg 2020 Jul;29(7S):S59-S66

The HSS Sports Medicine Institute, Hospital for Special Surgery, New York, NY, USA.

Background: Instability arthropathy is a known cause of glenohumeral osteoarthritis (OA) among patients with and without prior shoulder stabilization. This study aims to compare the clinical, radiographic, and patient-reported outcome measure (PROM) scores among total shoulder arthroplasty (TSA) patients with and without a history of shoulder stabilization.

Methods: A case-control study was performed comparing 20 patients with a history of anterior shoulder stabilization (11 open, 9 arthroscopic) who underwent TSA to a matched cohort of 20 TSA patients without a history of shoulder surgery (mean follow-up = 2. Read More

J Shoulder Elbow Surg 2020 Jul;29(7S):S126-S133

Department of Orthopedic Surgery, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

Introduction: As surgeons' confidence in reverse shoulder arthroplasty (RSA) increases, they may tend to offer RSA earlier in the course of glenohumeral joint disease. This study evaluates the changes in the "tipping point" for primary RSA over a 10-year period to evaluate changes in practice.

Methods: A total of 3975 primary RSAs performed over a 10-year period were retrospectively reviewed from a multi-institutional database. Read More

Croat Med J 2020 Jul;61(3):260-270

Domagoj Delimar, Department of Orthopedic Surgery, University Hospital Center Zagreb, Šalata 6, 10000 Zagreb, Croatia,

Developmental dysplasia of the hip (DDH) represents a morphological abnormality characterized by the incongruity of femoral head and acetabulum. It ranges from mild dysplastic changes to complete dislocation. DDH has been associated with several hereditary and environmental risk factors, which could explain the incidence variability among different countries. Read More

Musculoskeletal Care 2020 Jul 9. Epub 2020 Jul 9.

Department of Orthopaedics, Leiden University Medical Center (LUMC), Leiden, The Netherlands.

Objective: The purpose of this paper is to revise the 2010 Dutch guideline for physical therapy (PT) in patients with hip or knee osteoarthritis (OA), issued by the Royal Dutch Society for Physical Therapy (KNGF).

Method: This revised guideline was developed according to the Appraisal of Guidelines for Research and Evaluation (AGREE) and Guidelines International Network (G-I-N) standards. A multidisciplinary guideline panel formulated clinical questions based on perceived barriers to current care. Read More

Knee Surg Sports Traumatol Arthrosc 2020 Jul 8. Epub 2020 Jul 8.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK.

Purpose: Posterior cruciate ligament (PCL) deficiency is considered to be a contraindication for unicompartmental knee replacement (UKR); however, there is no evidence to support or contradict this. There are occasional circumstances where UKR in PCL deficient patients have been performed where the patient otherwise satisfies the indications for UKR. The aim of this paper is to describe the outcome of UKR in PCL deficient patients. Read More

J Orthop Translat 2020 Sep 2;24:39-45. Epub 2020 Jun 2.

Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Background/objective: The microstructure of the subchondral trabecular bone, including the composition and distribution of plates and rods, has an important influence on the disease progression and mechanical properties of osteoarthritis (OA) and osteoporosis (OP). We aimed to determine whether differences in plates and rods influence the variations in the quantities and qualities of the subchondral trabecular bone between OA and OP.

Materials And Methods: Thirty-eight femoral head samples [OA, n = 13; OP, n = 17; normal control (NC), n = 8] were collected from male patients undergoing total hip arthroplasty. Read More

Cureus 2020 Jun 6;12(6):e8481. Epub 2020 Jun 6.

Orthopedic Surgery, Sindh Government Qatar Hospital, Karachi, PAK.

Introduction: This study was conducted to evaluate the efficacy of proximal fibular osteotomy (PFO) in terms of pain relief, and improvement in function in medial compartment osteoarthritis (OA) of the knee joint.

Materials And Methods: This case series study was conducted at the Shaheed Mohtarma Benazir Bhutto Medical College Lyari and United Medical and Dental College of Karachi. Patients with medial compartment knee joint OA were included in the study and patients with bicompartmental or tricompartmental OA, inflammatory joint disease, valgus knee deformity, morbid obesity, or any infectious pathology involving the knee joint were excluded from the study. Read More

J Orthop 2020 Jul-Aug;20:326-331. Epub 2020 Jun 6.

Department of Orthopaedic Surgery at Diakovere Annastift, Hannover Medical School, Hannover, Germany.

Aim: Short-stem total hip arthroplasty is designed to preserve proximal bone stock in case of eventual revision, potentially benefiting younger and more active patients. This prospective, single-center study assessed the safety and performance of the partially neck-sparing Nanos™ short-stem uncemented prosthesis at 24 months using clinical outcome scores and radiographic results.

Methods: Between April 2011 and February 2015, 52 subjects (mean age, 54. Read More

J Vet Med Sci 2020 Jul 7. Epub 2020 Jul 7.

Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University.

Pentosan polysulfate (PPS) is a semi-synthetic sulfated polysaccharide compound which has been shown the benefits on therapeutic treatment for osteoarthritis (OA) and has been proposed as a disease modifying osteoarthritis drugs (DMOADs). This study investigated the effects of PPS on cell proliferation, particularly in cell cycle modulation and phenotype promotion of canine articular chondrocytes (AC). Canine AC were treated with PPS (0-80 µg/ml) for 24, 48 and 72 hr. Read More

BMJ Case Rep 2020 Jul 8;13(7). Epub 2020 Jul 8.

Melbourne Stem Cell Centre, Box Hill North, Victoria, Australia.

Osteochondral lesions (OCLs) of the talus are rare but can be associated with significant morbidity and may lead to the development of osteoarthritis. An improved understanding of the action of mesenchymal stem cells (MSCs) has seen renewed interest in their role in cartilage repair, with early preclinical and clinical research showing benefits in symptomatic and structural improvement. A 42-year-old man presented with an unstable OCL of the talus and onset of early osteoarthritis with a history of multiple previous ankle arthroscopies for ankle impingement. Read More

J Nanobiotechnology 2020 Jul 8;18(1):94. Epub 2020 Jul 8.

Department of Pain Medicine, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.

Background: Celastrol has been proven effective in anti-inflammatory but was limited in the clinic due to the poor solubility and side effects induced by low bioavailability. Osteoarthritis has acidic and inflammatory environment. Our aim was to load celastrol into HMSNs and capped with chitosan to construct a pH-responsive nanoparticle medicine (CSL@HMSNs-Cs), which is of high solubility for osteoarthritis intra-articular injection treatment. Read More

BMC Musculoskelet Disord 2020 Jul 8;21(1):446. Epub 2020 Jul 8.

Department of Orthopaedics, Xuanwu Hospital, Capital Medical University, Changchun Ave 45, Xicheng District, Beijing, 100053, China.

Background: The use of Oxford Unicompartmental Knee Arthroplasty (UKA) has increased rapidly in both Western and Asian populations, with excellent functional outcomes and high patient satisfaction. While previous evidence regarding clinical outcomes and survival rates after Oxford UKA was based on studies in Western populations, the results may be different in Asian patients. The relevance of age for postoperative function after Oxford UKA also remains unclear. Read More