143,673 results match your criteria Orthopaedics and Trauma [Journal]


Performance of stair negotiation in patients with cerebral palsy and stiff knee gait.

Gait Posture 2019 Apr 9;71:14-19. Epub 2019 Apr 9.

Clinic for Orthopedics and Trauma Surgery, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany; Pediatric Orthopaedics and Traumatology, University, Children's Hospital Zurich - Eleonore Foundation, Steinwiesstrasse 75, 8032 Zurich, Switzerland. Electronic address:

Background: Due to the limited knee range of motion, achieving adequate foot clearance while walking on level ground constitutes a major problem for patients with cerebral palsy and stiff knee gait. Stair negotiation as an activity of daily life requires a considerably higher knee range of motion than level ground walking, but little is known yet as to whether such patients are able to walk stairs.

Research Question: The aim of this study was to investigate how patients with a limited knee range of motion negotiate stairs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09666362183178
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http://dx.doi.org/10.1016/j.gaitpost.2019.04.005DOI Listing
April 2019
1 Read

Up-regulation of microRNA-496 suppresses proliferation, invasion, migration and in vivo tumorigenicity of human osteosarcoma cells by targeting eIF4E.

Biochimie 2019 Apr 15. Epub 2019 Apr 15.

The Second Department of Orthopedics, The Fifth Hospital of Harbin, Harbin, 150040, Heilongjiang Province, PR China. Electronic address:

Osteosarcoma is an aggressive bone tumor characterized by a high level of genetic instability and recurring DNA deletions and amplifications. This study aims to investigate how microRNA-496 (miR-496) affects proliferation, invasion, and migration of human osteosarcoma (OS) cells and in vivo tumorigenicity by targeting eukaryotic translation initiation factor 4E (eIF4E). Microarray-based gene expression profiling involving OS was used in order to identify differentially expressed genes. Read More

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http://dx.doi.org/10.1016/j.biochi.2019.04.017DOI Listing

Erratum to: What Factors Are Associated With Disability After Upper Extremity Injuries? A Systematic Review.

Clin Orthop Relat Res 2019 May;477(5):1256

P. Jayakumar, S. Lamb, S. Gwilym, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Medicine, University of Oxford, Nuffield Orthopaedic Centre, Oxford, UK C. L. Overbeek, Department of Orthopedic Surgery, Leiden University Medical Center, Leiden, The Netherlands M. Williams, Department of Sport and Health Sciences, Oxford Brookes University, Oxford, UK C. J. Funes, Department of Psychiatry (Behavioral Medicine Service), Boston, MA, USA D. Ring, The University of Texas at Austin, Department of Surgery and Perioperative Care, Dell Medical School, Austin, TX, USA A.-M. Vranceanu, Massachusetts General Hospital and Harvard Medical School, Behavioral Medicine Program, Department of Psychiatry, Boston, MA, USA.

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http://dx.doi.org/10.1097/CORR.0000000000000730DOI Listing

Cannulated Screw Prominence in Tension Band Wiring of Patella Fractures Increases Fracture Gapping: A Cadaver Study.

Clin Orthop Relat Res 2019 May;477(5):1249-1255

M. C. Avery, Department of Orthopaedics, Memorial Regional Healthcare System, Hollywood, FL, USA S. Jo, A. Chang, C. McAndrew, A. N. Miller, S. Tang, Department of Orthopaedics, Washington University in School of Medicine, Saint Louis, MO, USA W. M. Ricci, Department of Orthopaedics, Hospital for Special Surgery, New York, NY, USA.

Background: Transverse patella fractures are often treated with cannulated screws and a figure-of-eight anterior tension band. A common teaching regarding this construct is to recess the screws so that their distal ends do not protrude beyond the patella because doing so may improve biomechanical performance. However, there is a lack of biomechanical or clinical data to support this recommendation. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000683DOI Listing

CORR Insights®: Patient Age and Hip Morphology Alter Joint Mechanics in Computational Models of Patients with Hip Dysplasia.

Clin Orthop Relat Res 2019 May;477(5):1246-1248

A. E. Anderson, University of Utah Orthopaedics, Salt Lake City, UT, USA.

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http://dx.doi.org/10.1097/CORR.0000000000000715DOI Listing

CORR Insights®: What is the Association Between Hospital Volume and Complications After Revision Total Joint Arthroplasty: A Large-database Study.

Authors:
Olga D Savvidou

Clin Orthop Relat Res 2019 May;477(5):1232-1234

O. D. Savvidou, Associate Professor of Orthopaedics, National and Kapodistrian University of Athens, Medical School, First Department of Orthopaedics, ATTIKON University Hospital, Greece.

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http://dx.doi.org/10.1097/CORR.0000000000000743DOI Listing

What Is the Association Between Articular Cartilage Damage and Subsequent THA 20 Years After Hip Arthroscopy for Labral Tears?

Clin Orthop Relat Res 2019 May;477(5):1211-1220

M. K. Dwyer, C. Tumpowsky, J. Lee, J. C. McCarthy, Kaplan Joint Center, Newton Wellesley Hospital, Newton, MA, USA M. K. Dwyer, J. C. McCarthy, Department of Orthopaedics, Massachusetts General Hospital, Boston, MA, USA A. Boone, Tufts University School of Medicine, Boston, MA, USA.

Background: Few studies have examined long-term outcomes for patients after arthroscopic treatment for intraarticular hip conditions, and none have done so beyond 10 years postarthroscopy. Examining outcomes beyond 10 years is necessary to determine factors that contribute to conversion to THA in patients undergoing hip arthroscopy for labrochondral damage.

Questions/purposes: (1) What is hip survivorship free from THA in patients who underwent arthroscopic labral débridement, with or without chondroplasty at least 15 years before? (2) What factors are associated with conversion to THA after arthroscopic labral débridement, with or without chondroplasty? (3) Can these data be used to estimate the risk of conversion to THA based on patient- and hip-related factors?

Methods: Between 1989 and 2000, one surgeon performed 552 arthroscopic hip procedures for symptomatic labral tears, with or without associated articular cartilage damage. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000717DOI Listing

CORR Insights®: Is There a Force Target That Predicts Early Patient-reported Outcomes After Kinematically Aligned TKA?

Authors:
Robert A Siston

Clin Orthop Relat Res 2019 May;477(5):1208-1210

R. A. Siston, Department of Mechanical and Aerospace Engineering; Department of Orthopaedics; School of Health and Rehabilitation Sciences; The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1097/CORR.0000000000000751DOI Listing

Bilateral Femoroacetabular Impingement: What is the Fate of the Asymptomatic Hip?

Clin Orthop Relat Res 2019 May;477(5):983-989

I. Azboy , Department of Orthopaedics and Traumatology, Istanbul Medipol University School of Medicine, Istanbul, Turkey I. Azboy, H. H. Ceylan, H. Groff, H. Vahedi, J. Parvizi, The Rothman Institute at Thomas Jefferson University, Philadelphia, PA, USA.

Background: Bilateral symptomatic femoroacetabular impingement (FAI) is common. However, the fate of asymptomatic hip in patients with the radiographic diagnosis of bilateral FAI and unilateral symptoms remains unknown.

Questions/purposes: (1) What is the likelihood of the asymptomatic hip becoming painful in patients with unilateral symptoms but with radiographic evidence of bilateral femoroacetabular impingement? (2) What radiological and clinical factors are associated with the development of symptoms in an asymptomatic hip diagnosed with FAI?

Methods: A longitudinally maintained institutional FAI database was queried to collect relevant data for this retrospective study. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000699DOI Listing

Editorial Comment: The Bernese Hip Symposium and CORR®-Sharing the Latest and Best in Hip Surgery Research.

Authors:
Seth S Leopold

Clin Orthop Relat Res 2019 May;477(5):960-961

S. S. Leopold, Editor-In-Chief, Clinical Orthopaedics and Related Research®, Philadelphia, PA, USA.

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http://dx.doi.org/10.1097/CORR.0000000000000759DOI Listing

A Day at the Office: Private Practice and Private Equity.

Authors:
Douglas W Lundy

Clin Orthop Relat Res 2019 May;477(5):955-957

D. W. Lundy, Resurgens Orthopaedics, Atlanta, GA, USA.

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http://dx.doi.org/10.1097/CORR.0000000000000758DOI Listing

Editor's Spotlight/Take 5: Is the Risk of Infection Lower with Sutures than with Staples for Skin Closure After Orthopaedic Surgery? A Meta-analysis of Randomized Trials.

Authors:
Seth S Leopold

Clin Orthop Relat Res 2019 May;477(5):917-921

S. S. Leopold, Editor-In-Chief, Clinical Orthopaedics and Related Research®, Philadelphia, PA, USA.

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http://dx.doi.org/10.1097/CORR.0000000000000740DOI Listing

Hip Surveillance in Children With Cerebral Palsy.

J Am Acad Orthop Surg 2019 Apr 16. Epub 2019 Apr 16.

From the Department of Orthopedics, Alfred I. duPont Hospital for Children, Wilmington, DE (Dr. Shrader), the Texas Scottish Rite Hospital for Children, Dallas, TX (Dr. Wimberly), and the Orthopedic Institute for Children, University of California in Los Angeles, Los Angeles, CA (Dr. Thompson).

Hip dysplasia is common in children with cerebral palsy (CP), especially in those children with notable functional impairment. Severity of hip dysplasia has been shown to correlate with higher Gross Motor Function Classification System levels. Migration percentage measured on AP pelvis radiographs is the key radiographic measure quantifying hip displacement in CP. Read More

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http://dx.doi.org/10.5435/JAAOS-D-18-00184DOI Listing

Identification of noncoding RNA expression profiles and regulatory interaction networks following traumatic spinal cord injury by sequence analysis.

Aging (Albany NY) 2019 Apr 18. Epub 2019 Apr 18.

Jinan Central Hospital Affiliated to Shandong University, Jinan, China.

Aim: To systematically profile and characterize the noncoding RNA (ncRNA) expression pattern in the lesion epicenter of spinal tissues after traumatic spinal cord injury (TSCI) and predicted the structure and potential functions of the regulatory networks associated with these differentially expressed ncRNAs and mRNAs.

Results: A total of 498 circRNAs, 458 lncRNAs, 155 miRNAs and 1203 mRNAs were identified in TSCI mice models to be differentially expressed. The regulatory networks associated with these differentially expressed ncRNAs and mRNAs were constructed. Read More

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http://dx.doi.org/10.18632/aging.101919DOI Listing

Does Arthroscopic Suture-Spanning Augmentation of Single-Row Repair Reduce the Retear Rate of Massive Rotator Cuff Tear?

Am J Sports Med 2019 Apr 18:363546519836419. Epub 2019 Apr 18.

Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: Several surgical techniques have been proposed for massive rotator cuff tears (MRCTs), but the failure rates remain high. The suture-spanning augmentation technique of single-row (SSA-SR) repair was shown to reduce failure rates in cadaveric studies, but the outcome in vivo remains unclear.

Purpose: To determine if adding spanning sutures to SR repair during MRCT repairs can improve functional outcome and reduce failure rates. Read More

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http://dx.doi.org/10.1177/0363546519836419DOI Listing

[Effect of Bushen Yanggu Decoction on Multidrug Resistance of Multiple Myeloma Cell Line KM3/BTZ].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):482-488

Department of Orthopedics The Third Affiliated Hospital of Guangzhou University of Tranditional Chinese Medicine;Guangzhou 510000, Guangdong Province, China, E-mail:

Objective: To explore the effect of Bushen Yanggu Decoction (BYD) on drug resistance and proliferation of human multiple myeloma-resistant KM3/BTZ cells.

Methods: Human multidrug-resistant KM3/BTZ cells were established by Bortezomib (BTZ) gradient induction. The effects of commonly used chemotherapeutic drugs and serum containing Bushen Yanggu Decoction (BYD) on the proliferation of KM3 cells and KM3/BTZ cells were detected by MTT assay. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.028DOI Listing

[Effect of siRNA-Interfering β-Catenin Expression on MDR of Human Multiple Myeloma Cell Line].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):477-481

Department of Orthopedics, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China,E-mail:

Objective: To investigate the effecr of siRNA-interfering β-catenin expression on drug-resistance of multiple myeloma cells.

Methods: The multiple myeloma cell line RPMI-8226 was cultured in vitro. The maphalan-resistant cell model was established by concentration gradient ascending of durg, then the drug-resistant cell line was instantaneously transfected with β-catenin siRNA, the sensitivity of RPMI 8226 cells to maphalan was detected by CCK-8 meltod before and after the transfection with siRNA; the mRNA and protein expression of β-catenin was detected by qRT-PCR and Western blot respectively, the apoptosis of cells was detected by flow cytometry. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.027DOI Listing

Serum miR-21 expression correlates with radiographic progression but also low bone mineral density in patients with ankylosing spondylitis: a cross-sectional study.

Innate Immun 2019 Apr 18:1753425919842932. Epub 2019 Apr 18.

2 Department of Rehabilitation Medicine, Southern Medical University, Guang Zhou, China.

Increased expressions of miR-21 have been detected in ankylosing spondylitis (AS) patients. The current study was performed to examine the serum miR-21 expression with radiographic severity in AS patients, which was determined based on the modified New York (NY) criteria for sacroiliac joints assessment and modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) system for spine involvement. Bone mineral density at lumbar 1-4 and femoral neck were examined by dual-energy absorptiometry (DXA). Read More

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http://dx.doi.org/10.1177/1753425919842932DOI Listing

Patient-reported outcomes in hip resurfacing versus conventional total hip arthroplasty: a register-based matched cohort study of 726 patients.

Acta Orthop 2019 Apr 18:1-10. Epub 2019 Apr 18.

c Swedish Hip Arthroplasty Register , Gothenburg ;

Background and purpose - The theoretical mechanical advantages of metal-on-metal hip resurfacing (MoM-HR) compared with conventional total hip arthroplasty (THA) have been questioned. Studies including measures of patient-reported function, physical activity, or health-related quality of life have been sparse. We compared patient-reported outcomes in MoM-HR patients with a matched group of patients with conventional THA at 7 years post-surgery. Read More

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http://dx.doi.org/10.1080/17453674.2019.1604343DOI Listing

Quantitative Analysis of SSEA3+ Cells from Human Umbilical Cord after Magnetic Sorting.

Cell Transplant 2019 Apr 18:963689719844260. Epub 2019 Apr 18.

2 W.M. Keck Center for Collaborative Neuroscience, Rutgers, the State University of New Jersey, Piscataway, New Jersey, USA.

Multilineage-differentiating stress-enduring (Muse) cells are a population of pluripotent stage-specific embryonic antigen 3 (SSEA3)+ mesenchymal stem cells first described by Mari Dezawa in 2010. Although some investigators have reported SSEA3+ mesenchymal cells in umbilical cord tissues, none have quantitatively compared SSEA3+ cells isolated from Wharton's jelly (WJ) and the cord lining (CL) of human umbilical cords (HUCs). We separated WJ and the CL from HUCs, cultured mesenchymal stromal cells (MSCs) isolated from these two tissues with collagenase, and quantified the percentage of SSEA3+ cells over three passages. Read More

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http://dx.doi.org/10.1177/0963689719844260DOI Listing

Autologous activated platelet-rich plasma (PRP) in bone tissue healing - does it work? Assessment of PRP effect on bone defect healing in animal models.

Pol J Vet Sci 2019 Mar;22(1):109-115

Vetregen, Laboratory and Stem Cell Bank, Warsaw, Poland.

Introduction: Platelet-rich plasma (PRP) preparations can be used in bone tissue healing but there are numerous doubts among clinical orthopedists about effectiveness of this method.

Materials And Methods: The studies were carried out in 12 rabbits of white termond breed. In operating room we operationally generated cylindrical, unicortical defects of the diameter of 4 mm in the middle of the shafts of both femurs. Read More

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http://journals.pan.pl/dlibra/publication/127077
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http://dx.doi.org/10.24425/pjvs.2019.127077DOI Listing
March 2019
1 Read

'Golden Patient': A quality improvement project aiming to improve trauma theatre efficiency in the Royal Gwent Hospital.

BMJ Open Qual 2019 18;8(1):e000515. Epub 2019 Feb 18.

Orthopaedics, Royal Gwent Hospital, Newport, UK.

The efficiency of trauma lists when compared with elective orthopaedic lists is a frustration of many orthopaedic departments. At the Royal Gwent Hospital, late start times affecting total operating capacity of the trauma list were recognised as a problem within the department. The design team aimed to improve the start time of the list with the introduction of the 'golden patient' initiative. Read More

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http://dx.doi.org/10.1136/bmjoq-2018-000515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440604PMC
February 2019

ReGeneraTing Agents (RGTA): A new option for healing and improving treatment outcomes for traumatic and burn injuries of the hand.

Clin Case Rep 2019 Apr 17;7(4):619-625. Epub 2019 Feb 17.

OTR3 (Organe, Tissue, Régénération, Réparation, Remplacement) Paris France.

CACIPLIQ20 significantly improved the outcomes of severe burn injuries of the hand. Healing was accelerated, with little or no scarring, allowing for greater mobility over the joints and maintained suppleness. Functional recovery was achieved in all cases. Read More

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http://dx.doi.org/10.1002/ccr3.2054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452499PMC

Analysis of the Attune tibial tray backside: A comparative retrieval study.

Bone Joint Res 2019 Mar 2;8(3):136-145. Epub 2019 Apr 2.

Institute of Orthopaedics and Musculoskeletal Science, University College London and the Royal National Orthopaedic Hospital, Stanmore, UK.

Objectives: The Attune total knee arthroplasty (TKA) has been used in over 600 000 patients worldwide. Registry data show good clinical outcome; however, concerns over the cement-tibial interface have been reported. We used retrieval analysis to give further insight into this controversial topic. Read More

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http://dx.doi.org/10.1302/2046-3758.83.BJJ-2018-0102.R2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446526PMC
March 2019
1 Read

Blood supply in the bicipital groove: A histological analysis.

Orthop Rev (Pavia) 2019 Feb 29;11(1):8106. Epub 2019 Mar 29.

Clinic for Orthopedics.

The vascular anatomy in the closed bicipital groove with the long head of the biceps brachii muscle tendon (LHBT), its mesotenon and the transverse ligament intact has not been analyzed on a histological level yet. An anatomic dissection and histologic study was conducted by using 24 cadaveric formaldehyde fixated shoulders. The bicipital groove including the LHBT and its intact sheath was cut , fixated, sliced in 7 μm sections, Azan stained and the vascular anatomy analyzed under light microscopy. Read More

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http://dx.doi.org/10.4081/or.2019.8106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452089PMC
February 2019

Radiation safety education as a component of orthopedic training.

Orthop Rev (Pavia) 2019 Feb 27;11(1):7883. Epub 2019 Mar 27.

Department of Orthopedic Surgery, Tulane University School of Medicine, New Orleans, LA, USA.

Fluoroscopy poses an occupational hazard to orthopedic surgeons. The purpose of this study was to examine resident and faculty understanding of radiation safety and to determine whether or not a radiation safety intervention would improve radiation safety knowledge. An anonymous survey was developed to assess attitudes and knowledge regarding radiation safety and exposure. Read More

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http://dx.doi.org/10.4081/or.2019.7883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452227PMC
February 2019

Does surgeon experience influence the amount of radiation exposure during orthopedic procedures? A systematic review.

Orthop Rev (Pavia) 2019 Feb 12;11(1):7667. Epub 2019 Mar 12.

Section of Orthopedic Surgery, Department of Surgery, Aga Khan University, Karachi, Sindh, Pakistan.

With an increasing use of intraoperative fluoroscopy in operating rooms worldwide, the topic of radiation exposure has become a major concern among hospital staff, doctors and patients alike. Since fluoroscopy has become an integral part in orthopedic intraoperative management, we sought to identify whether surgeon grade or experience plays a role in the amount of radiation used and consequently exposed. We performed a systematic review examining the association between surgeon experience and radiation exposure using primary outcome measures (radiation dose and total screening time/fluoroscopy time). Read More

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http://dx.doi.org/10.4081/or.2019.7667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452094PMC
February 2019

First presentation of a Nora-lesion of the talus in a paraossal fasciitis.

Orthop Rev (Pavia) 2019 Feb 27;11(1):7628. Epub 2019 Mar 27.

Department of Orthopedics and Orthopedic Rheumatology, Elisabeth- Klinik, Olsberg.

Nora-Lesion is a proliferation that normally develops out of an intact corticalis. The entity of this fibroostotic pseudotumor, as discussed in literature, is triggered from repeating trauma or reactive periosteitis. In the literature, there are more than 200 cases defined as Nora lesion. Read More

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http://dx.doi.org/10.4081/or.2019.7628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452091PMC
February 2019

Intra-articular soft-tissue sarcoma of the knee: Is extra-articular resection and tumor endoprosthetic reconstruction the solution? A retrospective report on eight cases.

Orthop Rev (Pavia) 2019 Feb 26;10(1):7764. Epub 2019 Feb 26.

Department of Orthopedics and Tumor Orthopedics, Münster University Hospital, Münster.

Intra-articular sarcoma of the knee joint is a very rare condition. Extra-articular resection and reconstruction with a tumor prosthesis is usually performed. This report describes the results with this rare surgical procedure. Read More

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http://dx.doi.org/10.4081/or.2019.7764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397995PMC
February 2019

Increasing rates of surgical treatment for paediatric tibial shaft fractures: a national database study from between 2000 and 2012.

J Child Orthop 2019 Apr;13(2):213-219

Department of Orthopaedics Division of Pediatric Orthopaedic Surgery, Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Purpose: Tibia fractures are the third most common long bone fracture in children. Because of the remodelling potential of the tibial diaphysis, nonoperative treatment has historically been advocated for most tibial shaft fractures in children. The purpose of this study was to estimate the rate of surgical treatment of tibial shaft fractures over time and identify demographic factors associated with surgical treatment, utilizing a large, publicly available, national database. Read More

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http://dx.doi.org/10.1302/1863-2548.13.180163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442513PMC

Associations between risk factors and developmental dysplasia of the hip and ultrasonographic hip type: a retrospective case control study.

J Child Orthop 2019 Apr;13(2):161-166

University of Eskis¸ehir Osmangazi, Faculty of Medicine, Department of Orthopaedics and Traumatology, Eskis¸ehir, Turkey.

Purpose: We aimed to revisit the correlation between the previously defined risk factors and the occurrence of developmental dysplasia of the hip (DDH) and to assess the influence of these factors on the ultrasonographic type of hip dysplasia according to the Graf's classification in patients with DDH.

Methods: Data of healthy infants (mean age 33 days) who had bilateral mature (normal) hips (Graf type I) were compared with the data of infants (mean age 105 days) who were treated by abduction brace due to unilateral or bilateral DDH (Graf type IIa- and worse hips).

Results: Infants with at least one risk factor had a significantly higher rate of DDH than those with no risk factors (p < 0. Read More

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http://dx.doi.org/10.1302/1863-2548.13.180174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442512PMC

Serial ankle casts for patients with idiopathic toe walking: effects on functional gait parameters.

J Child Orthop 2019 Apr;13(2):147-154

University Center for Orthopaedics and Trauma Surgery, Carl Gustav Carus University Hospital, Technical University of Dresden, Dresden, Germany.

Purpose: The aim of the present study was to investigate the functional effects on gait parameters of serial ankle casts for patients with idiopathic toe walking (ITW), in comparison with an unremarkable control group.

Methods: A prospective trial with a pre-test-post-test control group design included ten patients with ITW and ten healthy matched children. Children with ITW underwent serial casting to stretch the plantar flexors, with two 14-day periods with walking plaster casts set at the maximum available ankle dorsiflexion. Read More

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http://dx.doi.org/10.1302/1863-2548.13.180183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442509PMC

Cobb Angle Measurement of Spine from X-Ray Images Using Convolutional Neural Network.

Comput Math Methods Med 2019 19;2019:6357171. Epub 2019 Feb 19.

Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan.

Scoliosis is a common spinal condition where the spine curves to the side and thus deforms the spine. Curvature estimation provides a powerful index to evaluate the deformation severity of scoliosis. In current clinical diagnosis, the standard curvature estimation method for assessing the curvature quantitatively is done by measuring the Cobb angle, which is the angle between two lines, drawn perpendicular to the upper endplate of the uppermost vertebra involved and the lower endplate of the lowest vertebra involved. Read More

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http://dx.doi.org/10.1155/2019/6357171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399566PMC
February 2019

STIM1 expression is associated with osteosarcoma cell survival.

Chin J Cancer Res 2019 Feb;31(1):203-211

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA.

Objective: To examine the role of store-operated calcium entry (SOCE) and stromal interaction molecule 1 (STIM1) in survival and migration of osteosarcoma cells and investigate what blockade of store-operated Ca contributes to the regulation of osteosarcoma cells.

Methods: First, we examined the expression levels of STIM1 in osteosarcoma cell lines by Western analysis and in tissue specimens by immunohistochemistry. Second, we investigated the effect of SOCE and STIM1 on osteosarcoma cell viability using MTS assays and on cell proliferation using colony formation. Read More

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http://dx.doi.org/10.21147/j.issn.1000-9604.2019.01.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433589PMC
February 2019

Long - Term survivorship and clinical and radiological follow - up of the primary uncemented Delta III reverse shoulder prosthesis.

J Orthop 2019 Jul-Aug;16(4):342-346. Epub 2019 Mar 24.

Department of Orthopedics Tergooiziekenhuizen, Van Riebeeckweg 212, 1213, XZ, Hilversum, the Netherlands.

Background: Purpose of this study was to evaluate the long - term survivorship and clinical and radiological results of a primary reverse total shoulder arthroplasty (RTSA) performed with uncemented stems.

Methods: From 2001 until 2006 61 primary uncemented RTSAs were implanted, which were included in a Kaplan-Meier survival analysis. Range of motion, functional scores and radiological follow - up was obtained. Read More

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http://dx.doi.org/10.1016/j.jor.2019.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451686PMC

Scaphoid specific volar locking plate and non-vascularised iliac crest bone graft in scaphoid non-union. A comparative cohort study.

J Orthop 2019 Jul-Aug;16(4):337-341. Epub 2019 Mar 25.

Department of Orthopaedics, Level 1 South, Western Health, Gordon Street Footscray, VIC 3011, Australia.

Scaphoid non-union develops in 10% of scaphoid fractures. There is sparse literature on fixation methods other than screws. We compared union rates following fixation of scaphoid non-union using screw fixation and a novel method of plate fixation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0972978X183058
Publisher Site
http://dx.doi.org/10.1016/j.jor.2019.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447723PMC
March 2019
1 Read

[Comparison of the effects of two cephalomedullary nails (zimmer natural nail and proximal femoral nail antirotation) in treatment of elderly intertrochan teric fractures].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):283-287

Department of Traumatology and Orthopaedics, Peking University People's Hospital, Beijing 100044, China.

Objective: To explore the effect of cephalomedullary nails for elderly intertrochanteric fractures: proximal femoral nail antirotation (PFNA) versus zimmer natural nail (ZNN) to provide the data support for clinical perioperative management.

Methods: A retrospective study was used to analyze the clinical data of elderly intertrochanteric fractures cases which were treated with PFNA or ZNN fixation from May 2016 to May 2017. In the study, 59 cases were followed up completely, in which 28 cases accepted PFNA, and the other 31 cases accepted ZNN. Read More

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[Application of the modified internal fixation method of minimally invasive percutaneous plate osteosynthesis in treatment of proximal humeral fracture].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):277-282

Department of Orthopedics, Peking University Third Hospital, Beijing 100191, China.

Objective: To study the clinical outcomes and characteristics of fracture healing of a modified internal fixation method, which was implemented by placing four and two screws respectively at the proximal and distal end of the locking plate in the minimally invasive percutaneous plate osteosynthesis (MIPPO) for patients with proximal humeral fractures.

Methods: Patients in Peking University Third Hospital from February 2010 to December 2016 were brought into this retrospective study. Based on different operation methods, they were divided into minimally invasive (MI) group and non-minimally invasive (non-MI) group, and the patients in MI group were performed with the modified internal fixation. Read More

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[Correlation analysis between rotator cuff tear and the superior migration of humeral head].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):273-276

Department of Trauma and Orthopaedics, Peking University People's Hospital, Peking University Trauma Medicine Center, Beijing 100044, China.

Objective: To evaluate the association between rotator cuff tear and the proximal migration of humeral head.

Methods: In this research, we retrospectively selected 30 patients with unilateral rotator cuff tear in Peking University People's Hospital from September 2015 to May 2016, who received magnetic resonance imaging (MRI) and X-ray of the painful shoulder before enrollment in this study, the duration between the two examinations was no longer than 1 week, and also there was no past history of surgery in the selected shoulders. There was no other exclusion criteria. Read More

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April 2019
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[Early functional recovery of direct anterior approach versus anterolateral approach for total hip arthroplasty].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):268-272

Department of Orthopaedics, Guizhou Provincial people's Hospital, Guiyang 550002, China.

Objective: To evaluate the early clinical effects of direct anterior approach (DAA) versus anterolateral approach (ALA) on safety and functional recovery following total hip arthroplasty (THA).

Methods: Between January 2015 and May 2016, a randomized clinical trial was performed at Guizhou Provincial People's Hospital. A total of 50 patients who underwent THA were allocated for either the DAA (n=25) or ALA (n=25). Read More

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[Pulsed electromagnetic fields stimulating osteogenic differentiation and maturation involves primary cilia-PI3K/AKT pathway].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):245-251

Institute of Orthopaedics, Lanzhou General Hospital of PLA, Lanzhou 730050, China.

Objective: To study whether the pulsed electromagnetic fields (PEMF) promoting rat osteoblasts differentiation and maturation is related to the primary cilia and PI3K/AKT pathway, and to explore the mechanism of PEMF in promoting bone differentiation.

Methods: Enzyme solution was used to obtain newborn SD rats calvarial osteoblasts (ROB), which were processed by 50 Hz 0.6 mT PEMF for 0, 0. Read More

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[Effects of sulfur dioxide on alveolar macrophage apoptosis in acute lung injury induced by limb ischemia/reperfusion in rats].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):239-244

Department of Orthopedics, Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China.

Objective: To investigate the effect of sulfur dioxide (SO) on the apoptosis of alveolar macrophage (AM) in lung protection of limb ischemia/reperfusion (I/R) induced acute lung injury (ALI), and to find a new target for the control of inflammatory response.

Methods: Twenty pathogen-free, adult male Sprague-Dawley (SD) rats (180-230 g) were used in this study. Five rats were to be used for limb ischemia/reperfusion, then plasma was extracted as ischemia/reperfusion serum stimulation. Read More

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Symptomatic postoperative spinal epidural hematoma after spine tumor surgery: Incidence, clinical features, and risk factors.

Spinal Cord 2019 Apr 17. Epub 2019 Apr 17.

Orthopaedic Oncology Center, Department of Orthopaedics, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Study Design: Case-control study.

Objectives: The objective of this study was to provide some useful information concerning the incidence, clinical features, and risk factors for symptomatic postoperative spinal epidural hematoma (SPSEH) in an isolated cohort of patients undergoing spine tumor surgery.

Setting: Hospital in Shanghai, China. Read More

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http://dx.doi.org/10.1038/s41393-019-0281-5DOI Listing

The effect of exogenous melatonin on reducing scoliotic curvature and improving bone quality in melatonin-deficient C57BL/6J mice.

Sci Rep 2019 Apr 17;9(1):6202. Epub 2019 Apr 17.

Department of Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing University, Nanjing, China.

It is well-documented that melatonin deficiency has been linked to the etiopathogenesis of adolescent idiopathic scoliosis. In this study, we intended to apply melatonin in melatonin-deficient mice to ascertain whether melatonin could reduce the incidence/severity of scoliosis, and investigate the role of melatonin on bone mineral density in scoliosis. A total of 80 mice were divided into 4 groups: 20 quadrupedal mice and 20 bipedal mice served as controls; 20 quadrupedal and 20 bipedal mice received oral melatonin (8 mg/kg BW) daily. Read More

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http://dx.doi.org/10.1038/s41598-019-42467-5DOI Listing

The roles of sirtuin 1 and its activator, resveratrol in osteoarthritis.

Biosci Rep 2019 Apr 17. Epub 2019 Apr 17.

Xiangya Hospital, Central South University, Changsha, China.

Osteoarthitis (OA) is the most common aging-related joint pathology; the aging process results in changes to joint tissues that ultimately contribute to the development of OA. Articular chondrocytes exhibit an aging-related decline in their proliferative and synthetic capacity. Sirtuin 1 (SIRT 1), a longevity gene related to many diseases associated with aging, is a NAD+-dependent protein deacetylase and master metabolic regulator. Read More

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http://dx.doi.org/10.1042/BSR20190189DOI Listing

Guide to presenting clinical prediction models for use in clinical settings.

BMJ 2019 04 17;365:l737. Epub 2019 Apr 17.

Centre for Prognosis Research, Research Institute for Primary Care and Health Sciences, Keele University, Keele, UK.

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http://dx.doi.org/10.1136/bmj.l737DOI Listing

Anti-CD166/4-1BB chimeric antigen receptor T cell therapy for the treatment of osteosarcoma.

J Exp Clin Cancer Res 2019 Apr 17;38(1):168. Epub 2019 Apr 17.

Department of Orthopedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, #88 Jie Fang Road, Hangzhou, 310009, Zhejiang, People's Republic of China.

Background: Chimeric antigen receptor (CAR)-engineered T cells have displayed outstanding performance in the treatment of patients with hematological malignancies. However, their efficacy against solid tumors has been largely limited.

Methods: In this study, human osteosarcoma cell lines were prepared, flow cytometry using antibodies against CD166 was performed on different cell samples. Read More

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http://dx.doi.org/10.1186/s13046-019-1147-6DOI Listing

EP1 receptor is involved in prostaglandin E2-induced osteosarcoma growth.

Bosn J Basic Med Sci 2019 Apr 18. Epub 2019 Apr 18.

Department of Hand and Foot Surgery, The Second Hospital Affiliated to Soochow University, Suzhou; Department of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei Anhui, China.

Recent studies showed that the activation of prostaglandin (PG) receptor EP1 promotes cell migration and invasion in different cancers. The aim of this study was to investigate the role of EP1 in the proliferation of osteosarcoma (OS) cells in vitro and in vivo. EP1 mRNA and protein levels were analyzed by real-time RT-PCR and Western blot, respectively in human OS cell lines MG63, OS732, U-2OS, HOS and SAOS-2 compared to human fetal osteoblastic hFOB 1. Read More

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http://www.bjbms.org/ojs/index.php/bjbms/article/view/4177
Publisher Site
http://dx.doi.org/10.17305/bjbms.2019.4177DOI Listing
April 2019
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Small Interfering LncRNA-TUG1 (siTUG1) decreases ketamine-induced neurotoxicity in Rat Hippocampal Neurons.

Int J Neurosci 2019 Apr 17:1-17. Epub 2019 Apr 17.

b Department of Neurology , Yantai Yuhuangding Hospital.

Background: Ketamine (KET) is known to be used in pediatric anaesthetic, whereas many evidences revealed that KET generated neurotoxicity. In our study, we found KET decreased the level of LncRNA taurine-upregulated gene 1 (TUG1). Hence, the aim of our study is to investigate whether small interfering TUG1 (siTUG1) has effect on KET-induced rat hippocampal neurons. Read More

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http://dx.doi.org/10.1080/00207454.2019.1594805DOI Listing