27,753 results match your criteria Organophosphates


Mechanisms of Pyrethroid Resistance in Aedes (Stegomyia) aegypti from Colombia.

Acta Trop 2018 Dec 12. Epub 2018 Dec 12.

Centro Internacional de Entrenamiento e Investigaciones Médicas CIDEIM, Carrera 125 N 19-225, Cali, Colombia; Universidad ICESI, Cali,Colombia. Electronic address:

In Colombia Aedes (Stegomyia) aegypti is the main vector of urban arboviruses such as dengue, chikungunya and Zika. This urban mosquito has a well-established capacity to develop insecticide resistance to different types of insecticides (pyrethroids, organochlorides, organophosphates), using multiple resistance mechanisms. An understanding of ongoing resistance mechanisms is critical to determining the activities of vector control programs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actatropica.2018.12.021DOI Listing
December 2018

Reusable Enzymatic Fiber Mats for Neurotoxin Remediation in Water.

ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.

Highly effective and reusable organophosphorus hydrolase (OPH)-loaded fiber mats have been fabricated that are capable of degrading toxic organophosphates (OPs) over a broad range of relevant concentrations (from 8 ppm to 8,250 ppm). The inherent fragility of enzymes, a major impediment in their incorporation into technologically-relevant materials, was overcome while retaining their high catalytic efficiency, selectivity and sensitivity via a random heteropolymers (RHP) approach. Kinetic analysis guides the design of polycaprolactone matrix morphology from films to fibers, facilitating substrate diffusion in the material. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.8b18484DOI Listing
December 2018
1 Read

Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus.

J Mol Neurosci 2018 Dec 4. Epub 2018 Dec 4.

Department of Neurology, The Chaim Sheba Medical Center, Tel HaShomer, 52621, Ramat Gan, Israel.

Organophosphates (OP) are a major threat to the health of soldiers and civilians due to their use as chemical weapons in war and in terror attacks. Among the acute manifestations of OP poisoning, status epilepticus (SE) is bearing the highest potential for long-term damages. Current therapies do not prevent brain damage and seizure-related brain injuries in OP-exposed humans. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12031-018-1228-6
Publisher Site
http://dx.doi.org/10.1007/s12031-018-1228-6DOI Listing
December 2018
1 Read

Chlorpyrifos- and Dichlorvos-Induced Oxidative and Neurogenic Damage Elicits Neuro-Cognitive Deficits and Increases Anxiety-Like Behavior in Wild-Type Rats.

Toxics 2018 Dec 1;6(4). Epub 2018 Dec 1.

Neuroscience Unit, Department of Anatomy, College of Health Sciences, University of Ilorin, P.M.B 1515, Ilorin 240003, Nigeria.

The execution of agricultural activities on an industrial scale has led to indiscriminate deposition of toxic xenobiotics, including organophosphates, in the biome. This has led to intoxication characterized by deleterious oxidative and neuronal changes. This study investigated the consequences of oxidative and neurogenic disruptions that follow exposure to a combination of two organophosphates, chlorpyrifos (CPF) and dichlorvos (DDVP), on neuro-cognitive performance and anxiety-like behaviors in rats. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/2305-6304/6/4/71
Publisher Site
http://dx.doi.org/10.3390/toxics6040071DOI Listing
December 2018
2 Reads

Effect of pesticide exposure on the cholinesterase activity of the occupationally exposed tea garden workers of Northern part of West Bengal, India.

Biomarkers 2018 Dec 4:1-16. Epub 2018 Dec 4.

a Genetics and Molecular Biology Laboratory, Department of Zoology , University of North Bengal , P.O. NBU , Dist. Darjeeling, 734013 , West Bengal , India.

Context: Pesticide poisoning and related deaths is a global concern, but there is little information about its effect on the occupationally exposed tea garden workers of North Bengal.

Objective: This study investigates the level of AChE and BuChE in the blood of the tea garden workers, at risk of exposure to a mixture of pesticides.

Materials And Methods: The study sample consisted of pesticide exposed workers, non exposed (control), smokers and alcoholics. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/1354750X.2018.1
Publisher Site
http://dx.doi.org/10.1080/1354750X.2018.1556342DOI Listing
December 2018
2 Reads

Insecticide resistance status, frequency of L1014F Kdr and G119S Ace-1 mutations, and expression of detoxification enzymes in Anopheles gambiae (s.l.) in two regions of northern Benin in preparation for indoor residual spraying.

Parasit Vectors 2018 Dec 4;11(1):618. Epub 2018 Dec 4.

Centre de Recherche entomologique de Cotonou (CREC), Cotonou, Benin.

Background: This study aims to provide baseline data on the resistance status to insecticides, the frequency of mechanisms involved and the impact of the association with the synergist piperonyl butoxide (PBO) on resistant Anopheles gambiae (s.l.) populations in two regions of northern Benin, prior to an indoor residual spraying campaign and introduction of next generation long-lasting insecticidal nets (LLINs) incorporating PBO. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13071-018-3180-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278060PMC
December 2018
3 Reads

Neuroprotection From Organophosphate-Induced Damage by Novel Phenoxyalkyl Pyridinium Oximes in Rat Brain.

Toxicol Sci 2018 Dec;166(2):420-427

Center for Environmental Health Sciences.

The nerve agents are extremely toxic organophosphates which lead to massive inhibition of acetylcholinesterase (AChE) in both the central and peripheral nervous systems. The currently approved pyridinium oxime reactivators of organophosphate-inhibited AChE (eg, 2-PAM in the United States) cannot penetrate the blood-brain barrier because of the permanent positive charge in the pyridinium ring. Therefore these current oximes cannot rescue inhibited AChE in the brain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/toxsci/kfy212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260155PMC
December 2018
2 Reads

Effect of sub-toxic exposure to Malathion on glucose uptake and insulin signaling in L6 myoblast derived myotubes.

Drug Chem Toxicol 2018 Nov 29:1-8. Epub 2018 Nov 29.

a Department of Biochemistry , Maulana Azad Medical College , New Delhi , India.

Biochemical basis of Malathion exposure-induced diabetes mellitus is not known. Hence, effects of its sub-toxic exposure on redox sensitive kinases (RSKs), insulin signaling and insulin-induced glucose uptake were assessed in rat muscle cell line. In this in vitro study, rat myoblast (L6) cells were differentiated to myotubes and were exposed to sub-toxic concentrations (10 mg/l and 20 mg/l) of Malathion for 18 hours. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01480545.2018.1531881DOI Listing
November 2018

Migrant Farmworkers' Exposure to Pesticides in Sonora, Mexico.

Int J Environ Res Public Health 2018 11 26;15(12). Epub 2018 Nov 26.

Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave. PO 245210, Tucson, AZ 85724, USA.

Expanding agribusiness in Sonora, a state in Northern Mexico, has increased the demand for temporary migrant agricultural workers. Sonora is one of the top states in Mexico for pesticide utilization. We conducted an exploratory study to evaluate exposure to organophosphate (OP) and pyrethroid pesticides among migrant farmworkers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph15122651DOI Listing
November 2018

Biocatalytic membrane reactor development for organophosphates degradation.

J Hazard Mater 2018 Nov 17;365:789-795. Epub 2018 Nov 17.

Institute on Membrane Technology, National Research Council, ITM-CNR, via P. Bucci, 17/C, 87036 Rende, Cosenza, Italy.

Organophosphates (OPs) are highly toxic compounds used as pesticides and nerve agents. The devastating effects, reported in different studies, on the environment and human health indicate a serious scenario for both instantaneous and long terms effects. Bio-based strategies for OPs degradation seem the most promising solutions, particularly when extremophiles enzymes are used. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03043894183109
Publisher Site
http://dx.doi.org/10.1016/j.jhazmat.2018.11.063DOI Listing
November 2018
6 Reads

Meta-Analysis of Insecticides in United States Surface Waters: Status and Future Implications.

Environ Sci Technol 2018 Dec 6;52(24):14452-14460. Epub 2018 Dec 6.

Institute for Environmental Sciences , University of Koblenz-Landau , Fortstrasse 7 , D-76829 Landau , Germany.

Agricultural insecticides occur in U.S. surface waters, yet our knowledge of their current and potential future large-scale risks for biodiversity is restricted. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.est.8b04651
Publisher Site
http://dx.doi.org/10.1021/acs.est.8b04651DOI Listing
December 2018
4 Reads

Quantifying the Impact of Excluding Insecticide Classes From Cotton Integrated Pest Management Programs in the U.S. Mid-South.

J Econ Entomol 2018 Nov 20. Epub 2018 Nov 20.

Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, Mississippi State, MS.

Current assessments from the U.S. Environmental Protection Agency suggest that some current insecticides may be lost or severely restricted in the near future. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jee/toy339DOI Listing
November 2018
2 Reads

Monitoring Insecticide Resistance Profiles of Aedes aegypti (Diptera: Culicidae) in the Sunda Islands of Indonesia Based on Diagnostic Doses of Larvicides.

J Med Entomol 2018 Nov 20. Epub 2018 Nov 20.

Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.

This study was conducted to monitor the susceptibility status of Aedes aegypti (Linnaeus) larvae in the Sunda Islands of Indonesia against various organophosphates and organochlorines. Larval bioassay was performed in accordance with the World Health Organization standard protocol. Field-collected and reference strains of Ae. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jme/tjy208DOI Listing
November 2018
5 Reads

Blood-Brain Barrier Cellular Responses Toward Organophosphates: Natural Compensatory Processes and Exogenous Interventions to Rescue Barrier Properties.

Front Cell Neurosci 2018 16;12:359. Epub 2018 Oct 16.

The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.

Organophosphorus compounds (OPs) are highly toxic chemicals widely used as pesticides (e.g., paraoxon (PX)- the active metabolite of the insecticide parathion) and as chemical warfare nerve agents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fncel.2018.00359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232705PMC
October 2018
6 Reads

Cholinergic Modulation of CA1 Pyramidal Cells via M1 Muscarinic Receptor Activation: A Computational Study at Physiological and Supraphysiological Levels.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:1396-1399

The hippocampus receives extensive cholinergic modulation from the basal forebrain, which has been shown to have a prominent role in attention, learning, and synaptic plasticity. Disruptions of this modulation have been linked to a variety of neural disorders including Alzheimer's Disease. Pyramidal cells of the CA1 region of the hippocampus express several cholinergic receptor types in different locations throughout the cells' morphology. Read More

View Article

Download full-text PDF

Source
https://ieeexplore.ieee.org/document/8512574/
Publisher Site
http://dx.doi.org/10.1109/EMBC.2018.8512574DOI Listing
July 2018
2 Reads

FTY720P inhibits the Na/K ATPase in Caco-2 cells via S1PR2: PGE2 and NO are along the signaling pathway.

Life Sci 2018 Dec 12;215:198-206. Epub 2018 Nov 12.

Department of Biology, Faculty of Arts & Sciences, American University of Beirut, Beirut, Lebanon. Electronic address:

Aims: Sphingosine-1-phosphate (S1P) has been implicated lately in inflammatory bowel disease which has diarrhea as one of its symptoms. Diarrhea is due to altered water movements as a result of altered electrolyte transport, and in particular sodium. Sodium movements are geared by the sodium gradient established by the Na/K ATPase. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00243205183073
Publisher Site
http://dx.doi.org/10.1016/j.lfs.2018.11.026DOI Listing
December 2018
5 Reads

One-year mortality among hospital survivors of cholinesterase inhibitor poisoning based on Taiwan National Health Insurance Research Database from 2003 to 2012.

BMC Pharmacol Toxicol 2018 Nov 13;19(1):72. Epub 2018 Nov 13.

Department of Pulmonary and Critical Care Medicine, Chiayi Chang-Gung Memorial Hospital, No. 6, Sec. West, Chia-Pu Road, Pu-Tz City, Chiayi, 613, Taiwan.

Background: Acute cholinesterase inhibitor (CI) poisoning, including organophosphate and carbamate poisoning, is a crucial problem in developing countries. Acute intoxication results in a cholinergic crisis, neurological symptoms, or respiratory failure. However, the short-term and long-term outcomes of CI poisoning are seldom reported. Read More

View Article

Download full-text PDF

Source
https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s40360-018-0263-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234557PMC
November 2018
3 Reads

Pesticides as the drivers of neuropsychotic diseases, cancers, and teratogenicity among agro-workers as well as general public.

Environ Sci Pollut Res Int 2018 Nov 8. Epub 2018 Nov 8.

Department of Ecology and Environmental Sciences, Pondicherry University, Puducherry, 605014, India.

The need to maximize agricultural productivity has made pesticides an indispensable part of current times. Farmers are unaware of the lurking consequences of the pesticide exposure, which endanger their health. It also puts the unsuspecting consumers in peril. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-018-3642-2DOI Listing
November 2018

Evidence of Insecticide Resistance to Pyrethroids and Bendiocarb in from Tsararano, Marovoay District, Madagascar.

Biomed Res Int 2018 8;2018:5806179. Epub 2018 Oct 8.

Institut Pasteur de Madagascar, G4 Malaria Group, Ambatofotsikely, Antananarivo 101, Madagascar.

Introduction: In Madagascar, malaria control relies on the countrywide use of long lasting insecticide treated bed nets (LLINs) and on indoor residual spraying (IRS) in the central highland area as well as a small area on the eastern coast. We tested insecticide resistance mechanisms of from Tsararano, a malaria endemic village in the coastal health district of Marovoay.

Methods: Insecticide susceptibility bioassays were done in July 2017 on first-generation (F1) to assess (i) the susceptibility to permethrin (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/5806179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196927PMC
October 2018

Hydrophilic scaffolds of oxime as the potent catalytic inactivator of reactive organophosphate.

Chem Biol Interact 2019 Jan 25;297:67-79. Epub 2018 Oct 25.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, United States; Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan Medical School, Ann Arbor, MI 48109, United States. Electronic address:

Despite its efficacy as a skin decontaminant of reactive organophosphates (OP), Dekon 139-a potassium salt of 2,3-butanedione monooxime (DAM)-is associated with adverse events related to percutaneous absorption largely due to its small size and lipophilicity. In order to address this physicochemical issue, we synthesized and evaluated the activity of a focused library of 14 hydrophilic oxime compounds, each designed with either a DAM or monoisonitrosoacetone (MINA) oxime tethered to a polar or charged scaffold in order to optimize the size, hydrophilicity, and oxime acidity. High-throughput colorimetric assays were performed with paraoxon (POX) as a model OP to determine the kinetics of POX inactivation by these compounds under various pH and temperature conditions. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00092797183113
Publisher Site
http://dx.doi.org/10.1016/j.cbi.2018.10.022DOI Listing
January 2019
3 Reads

Homicidal poisoning in India: A short review.

J Forensic Leg Med 2018 Oct 23;61:13-16. Epub 2018 Oct 23.

Department of Forensic Medicine, ESIC Medical College & Hospital, NH3, NIT3, Faridabad, 121001, India. Electronic address:

This review has analysed various studies and case reports on homicide by poison from different parts of India till date. This review shows that homicidal poisoning prevalence varies from 0.3% to 3. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S1752928X183031
Publisher Site
http://dx.doi.org/10.1016/j.jflm.2018.10.003DOI Listing
October 2018
3 Reads

Differential proteome analysis of rat plasma after diisopropyl fluorophosphate (DFP) intoxication, a surrogate of nerve agent sarin.

Chem Biol Interact 2018 Oct 30;298:66-71. Epub 2018 Oct 30.

Defence Research & Development Establishment (DRDE), Jhansi Road, Gwalior, MP, 474002, India. Electronic address:

Diisopropyl fluorophosphate (DFP), a surrogate of nerve agent sarin, is an organophosphorus (OP) compound which inhibits neuronal enzyme acetylcholinesterase (AChE). Exposure of this compound leads to a wide range of toxic symptoms and survivors may exhibit long term neurotoxicity related to cognitive and memory defects. Due to ease of availability and similar mechanism of action to other highly toxic nerve agent, DFP is widely used as model compound to trace changes associated with nerve agent exposures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2018.10.026DOI Listing
October 2018
9 Reads

Chlorpyrifos Induction of Testicular-Cell Apoptosis through Generation of Reactive Oxygen Species and Phosphorylation of AMPK.

J Agric Food Chem 2018 Nov 15;66(47):12455-12470. Epub 2018 Nov 15.

College of Animal Science and Technology , Northwest A&F University , Yangling , Shaanxi 712100 , China.

Chlorpyrifos (CPF) is the most frequently applied insecticide. Aside from effects on the neuronal cholinergic system, previous studies suggested a potential relationship between CPF exposure and male infertility; however, the molecular mechanism remains elusive. The aim of this study was to investigate the toxic effect of CPF on testicular cells and the potential mechanism via in vitro and in vivo experiments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jafc.8b03407DOI Listing
November 2018
2 Reads

Caligus rogercresseyi acetylcholinesterase types and variants: a potential marker for organophosphate resistance.

Parasit Vectors 2018 Oct 30;11(1):570. Epub 2018 Oct 30.

Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Sea Lice Research Centre, Postboks 369 Sentrum, Oslo, NO-0102, Norway.

Background: Control of the sea louse Caligus rogercresseyi in the Chilean salmonid industry is reliant on chemical treatments. Azamethiphos was introduced in 2013, although other organophosphates were previously used. In 2014, reduced sensitivity to azamethiphos was detected in the Los Lagos Region using bioassays. Read More

View Article

Download full-text PDF

Source
https://parasitesandvectors.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s13071-018-3151-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208076PMC
October 2018
4 Reads

miR-513a-5p targets Bcl-2 to promote dichlorvos induced apoptosis in HK-2 cells.

Biomed Pharmacother 2018 Dec 25;108:876-882. Epub 2018 Sep 25.

Tongren College, Tongren, 554300, Guizhou, China.

miRNAs are crucially involved in cellular responses to exotic chemical toxins. However, the role of miRNAs in organophosphates induced cytotoxicity is poorly understood. In present study, we investigated the role of miR-513a-5p in dichlorvos induced cytotoxicity in human kidney cell line HK-2. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07533322183270
Publisher Site
http://dx.doi.org/10.1016/j.biopha.2018.09.101DOI Listing
December 2018
1 Read

Oxidative grafting vs. monolayers self-assembling on gold surface for the preparation of electrochemical immunosensors. Application to the determination of peptide YY.

Talanta 2019 Feb 25;193:139-145. Epub 2018 Sep 25.

Department of Analytical Chemistry, Faculty of Chemistry, University Complutense of Madrid, 28040 Madrid, Spain.

A comparison of the performance of two electrochemical immunosensors for the determination of the anorexigen biomarker peptide YY (PYY) is reported by using as scaffolds screen printed gold electrodes modified either by oxidative grafting of p-aminobenzoic acid (p-ABA) or by assembling of a 4-mercaptobenzoic acid (4-MBA) SAM. Covalent immobilization of capture antibodies on the surface-confined carboxyl groups was carried out by EDC/NHSS chemistry, and competitive immunoassays between target PYY and Biotin-PYY were implemented. Upon labeling with alkaline phosphatase (AP)-streptavidin conjugate and 1-naphtyl phosphate addition, differential pulse voltammograms recorded between -0. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00399140183101
Publisher Site
http://dx.doi.org/10.1016/j.talanta.2018.09.089DOI Listing
February 2019
3 Reads

Insecticide-resistance mechanism of Plutella xylostella (L.) associated with amino acid substitutions in acetylcholinesterase-1: A molecular docking and molecular dynamics investigation.

Comput Biol Chem 2018 Dec 8;77:240-250. Epub 2018 Sep 8.

Centre for Agricultural Bioinformatics, Indian Agricultural Statistical Research Institute, Pusa, New Delhi, 110012, India.

Acetylcholinesterase-1 (AChE1) is a vital enzyme involved in neurotransmission and represents an attractive insecticide-target for organophosphates and carbamates in Plutella xylostella (Linneaus), an important pest of cruciferous crops worldwide. However, insecticide-resistance often occurs due to mutations, making many organophosphates and carbamates ineffective. In particular, A298S and G324A mutations in AChE1 significantly lower the binding affinity of insecticides. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14769271183038
Publisher Site
http://dx.doi.org/10.1016/j.compbiolchem.2018.09.004DOI Listing
December 2018
9 Reads

Paraoxonase-1 genetic polymorphisms in organophosphate metabolism.

Toxicology 2019 Jan 22;411:24-31. Epub 2018 Oct 22.

Laboratory of Toxicology, School of Medicine, University of Crete, 71003, Heraklion, Greece.

Organophosphates (OPs) are a class of chemicals commonly used in agriculture as pesticides, that can often lead to severe toxicity in humans. Paraoxonase-1 (PON1) belongs to a family of A-esterases and hydrolyses several OPs while also serving other biological roles. Two main genetic polymorphisms have been shown to affect enzymatic ability; an A > G transition in the 192nd position (192 Q/R, rs662), and an A > T at codon 55 (55 M/L, rs854560). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0300483X183048
Publisher Site
http://dx.doi.org/10.1016/j.tox.2018.10.012DOI Listing
January 2019
7 Reads

Puzzling Reaction of Imidazole with Methyl Parathion: P=S versus P=O Mechanistic Shift Dilemma in Organophosphates.

Chemistry 2018 Oct 24. Epub 2018 Oct 24.

Department of Chemistry, Universidade Federal do Paraná, CP 19081, CEP 81531-990, Curitiba-PR, Brazil.

Organophosphates (OPs) constitute many toxic agrochemicals and warfare and can undergo a wide spectrum of mechanisms, some which are fairly unexplored. In this sense, concise mechanistic elucidation stands out as a strategic tool for achieving efficient detoxification and for monitoring processes. Particularly intriguing is the effect of substituting the oxygen atom of the phosphoryl moiety (P=O) in OPs with a sulfur atom to give the thio-derived OPs (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/chem.201804107DOI Listing
October 2018
1 Read

Serum β-glucuronidase activity as a biomarker for acute cholinesterase inhibitor pesticide poisoning.

Toxicol Ind Health 2018 Oct 23:748233718802068. Epub 2018 Oct 23.

3 Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Tanta University, Tanta, Egypt.

β-glucuronidase (BG) activity is a promising biomarker for diagnosis and prognosis after exposure to organophosphorous (OP) pesticides. The aim of this study was to evaluate the changes in serum BG activity in patients with acute OP poisoning and to determine whether these changes correlate with the severity of poisoning. Thirty patients with anticholinesterase pesticide poisoning were included, besides 10 healthy volunteers as a control group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0748233718802068DOI Listing
October 2018

Rinsing Tea before Brewing Decreases Pesticide Residues in Tea Infusion.

J Agric Food Chem 2018 Oct 23. Epub 2018 Oct 23.

State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science & Technology , Anhui Agricultural University , Hefei , Anhui 230036 , People's Republic of China.

Rinsing dried tea leaves before brewing is a traditional way of preparing rolled oolong tea in China. This study analyzes how rinsing green, black, and oolong tea before brewing affects the levels of pesticide residues in the tea infusion. Eight representative insecticides of different polarities were tracked, namely, three neonicotinoids (acetamiprid, imidacloprid, and thiamethoxam), two organophosphates (dimethoate and malathion), and three pyrethroids (bifenthrin, β-cypermethrin, and fenvalerate). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jafc.8b04908DOI Listing
October 2018
1 Read

A novel fluorescence "turn off-on" nanosensor for sensitivity detection acid phosphatase and inhibitor based on glutathione-functionalized graphene quantum dots.

Talanta 2019 Jan 5;192:61-68. Epub 2018 Sep 5.

Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun 130012, China. Electronic address:

In this paper, we developed a label-free and sensitive fluorescence sensor for acid phosphatase (ACP) and its inhibitor parathion-methyl (PM) detection based on glutathione-functionalized graphene quantum dots (GQDs@GSH). Upon addition of MnO nanosheets, the fluorescence of GQDs@GSH could be efficiently quenched via a fluorescence resonance energy transfer. ACP could easily catalyze the hydrolysis of L-Ascorbic acid-2-phosphate (AAP) to ascorbic acid (AA), which could reduce MnO nanosheets to Mn in acidic environment, leading to dramatically increase of the fluorescence intensity of GQDs@GSH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.talanta.2018.09.009DOI Listing
January 2019

Phthalates and organophosphates in settled dust and HVAC filter dust of U.S. low-income homes: Association with season, building characteristics, and childhood asthma.

Environ Int 2018 Dec 20;121(Pt 1):916-930. Epub 2018 Oct 20.

Department of Civil, Architectural and Environmental Engineering, The University of Texas at Austin, TX, USA; Department of Building Science, Tsinghua University, Beijing, China. Electronic address:

Phthalates and organophosphates are ubiquitous indoor semi-volatile organic contaminants (SVOCs) that have been widely used as plasticizers and flame retardants in consumer products. Although many studies have assessed their levels in house dust, only a few used dust samples captured by filters of building heating, ventilation, and air conditioning (HVAC) systems. HVAC filters collect particles from large volumes of air over a long period of time (potentially known) and thus provide a spatially and temporally integrated concentration. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01604120183149
Publisher Site
http://dx.doi.org/10.1016/j.envint.2018.09.013DOI Listing
December 2018
5 Reads
5.560 Impact Factor

Prevention of pesticide-induced neuronal dysfunction and mortality with nucleophilic poly-Oxime topical gel.

Sci Adv 2018 Oct 17;4(10):eaau1780. Epub 2018 Oct 17.

Institute for Stem Cell Biology and Regenerative Medicine (inStem), GKVK Campus, Bellary Road, Bangalore, 560065 Karnataka, India.

Organophosphate-based pesticides inhibit acetylcholinesterase (AChE), which plays a pivotal role in neuromuscular function. While spraying in the field, farmworkers get exposed to pesticides through the dermal route. Internalized pesticide inhibits AChE, which leads to neurotoxicity, cardiotoxicity, cognitive dysfunction, loss of endurance, and death in severe cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.aau1780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192682PMC
October 2018
4 Reads

Investigating the potential for transisomerisation of trycresyl phosphate with a palladium catalyst and its implications for aircraft cabin air quality.

Chemosphere 2019 Jan 13;215:532-534. Epub 2018 Oct 13.

Environnement International, Orrouy, France.

The quality of aircraft cabin air has been an area of concern for several decades. Many investigations have linked the presence of organophosphates in air to Aerotoxic Syndrome with adverse symptoms reported by thousands of aircraft crew across the globe. Currently the source of organophosphates has been under debate, with studies pointing towards tricresylphosphates (TCP) in aircraft oil as the main source due to leaks in engine seals resulting in fumes entering the cabin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2018.10.082DOI Listing
January 2019

Temporal variations and potential sources of organophosphate esters in PM in Xinxiang, North China.

Chemosphere 2019 Jan 10;215:500-506. Epub 2018 Oct 10.

State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China.

We monitored the concentrations of 10 organophosphate esters (OPEs) in 52 fine particulate matter (PM) samples in Xinxiang, Henan Province, North China, in 2015. During the sampling period, the OPE concentrations in most samples (n = 47) differed minimally and were relatively stable (mean: 2.02 ± 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2018.10.063DOI Listing
January 2019
3.340 Impact Factor

Corticosterone and pyridostigmine/DEET exposure attenuate peripheral cytokine expression: Supporting a dominant role for neuroinflammation in a mouse model of Gulf War Illness.

Neurotoxicology 2018 Oct 16;70:26-32. Epub 2018 Oct 16.

Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA. Electronic address:

Gulf War Illness (GWI) is a chronic multi-symptom disorder experienced by as many as a third of the veterans of the 1991 Gulf War; the constellation of "sickness behavior" symptoms observed in ill veterans is suggestive of a neuroimmune involvement. Various chemical exposures and conditions in theater have been implicated in the etiology of the illness. Previously, we found that GW-related organophosphates (OPs), such as the sarin surrogate, DFP, and chlorpyrifos, cause neuroinflammation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2018.10.006DOI Listing
October 2018
3 Reads
3.380 Impact Factor

Inhibition of miR-128 Abates Aβ-Mediated Cytotoxicity by Targeting PPAR-γ via NF-κB Inactivation in Primary Mouse Cortical Neurons and Neuro2a Cells.

Yonsei Med J 2018 Nov;59(9):1096-1106

Department of Rehabilitation Medicine, Huaihe Hospital of Henan University, Kaifeng, China.

Purpose: Alzheimer's disease (AD) is the sixth most common cause of death in the United States. MicroRNAs have been identified as vital players in neurodegenerative diseases, including AD. microRNA-128 (miR-128) has been shown to be dysregulated in AD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3349/ymj.2018.59.9.1096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192880PMC
November 2018
2 Reads

Molecular insights into the mechanism and the efficiency-structure relationship of phosphorus removal by coagulation.

Water Res 2018 Dec 5;147:195-203. Epub 2018 Oct 5.

Department of Environmental Engineering, Peking University, Beijing, 100871, People's Republic of China; The Key Laboratory of Water and Sediment Sciences, Ministry of Education, Beijing, 100871, People's Republic of China. Electronic address:

Types and structures of phosphorus compounds influence the removal of phosphorus by coagulation. Until now, the molecular-level interaction between coagulants and phosphorus (especially organophosphates) and the relationship between removal efficiency and phosphorus structure have not been clear. This work investigated the removal of phosphorus with different structures using conventional coagulants (poly aluminum chloride (PACl) and polymerized ferric sulfate (PFS)) and a novel covalently-bound inorganic-organic hybrid coagulant (CBHyC). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00431354183079
Publisher Site
http://dx.doi.org/10.1016/j.watres.2018.10.006DOI Listing
December 2018
8 Reads

Uptake and toxic effects of triphenyl phosphate on freshwater microalgae Chlorella vulgaris and Scenedesmus obliquus: Insights from untargeted metabolomics.

Sci Total Environ 2019 Feb 5;650(Pt 1):1239-1249. Epub 2018 Sep 5.

Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore; NUS Environmental Research Institute (NERI), #02-01, T-Lab Building (TL), 5A Engineering Drive 1, Singapore 117411, Singapore. Electronic address:

The flame retardant triphenyl phosphate (TPhP) has been widely detected in surface waters. Yet, little information is known regarding its impact on microalgae. We investigated the uptake and toxicity of TPhP on two freshwater microalgae Chlorella vulgaris (CV) and Scenedesmus obliquus (SO) after exposure to 10 μg/l-10 mg/l for 5 days. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00489697183344
Publisher Site
http://dx.doi.org/10.1016/j.scitotenv.2018.09.024DOI Listing
February 2019
12 Reads

Isolation and Functional Characterization of New Terpene Synthase Genes from Traditional Edible Plants.

J Oleo Sci 2018 ;67(10):1235-1246

Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University.

Terpene synthase (TPS) genes were isolated and functionally characterized from three traditional edible plants, Acanthopanax sciadophylloides ("Koshiabura") and Acanthopanax sieboldianus ("Himeukogi"), belonging to the family Araliaceae, and Curcuma zedoaria (zedoary, "Gajutsu"), belonging to the family Zingiberaceae. These plants emit characteristic fragrances and are used for traditional foods and folk medicines. From their fragrant tissues, i. Read More

View Article

Download full-text PDF

Source
https://www.jstage.jst.go.jp/article/jos/67/10/67_ess18163/_
Publisher Site
http://dx.doi.org/10.5650/jos.ess18163DOI Listing
November 2018
6 Reads

Non-target site-based resistance to tribenuron-methyl and essential involved genes in Myosoton aquaticum (L.).

BMC Plant Biol 2018 Oct 11;18(1):225. Epub 2018 Oct 11.

Key Laboratory of Pesticide Toxicology and Application Technique, College of Plant Protection, Shandong Agricultural University, Taian, 271018, Shandong, China.

Background: Water chickweed (Myosoton aquaticum (L.)) is a dicot broadleaf weed that is widespread in winter fields in China, and has evolved serious resistance to acetolactate synthase (ALS) inhibiting herbicides.

Results: We identified a M. Read More

View Article

Download full-text PDF

Source
https://bmcplantbiol.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12870-018-1451-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180388PMC
October 2018
8 Reads
3.810 Impact Factor

Arginine in the FARM and SARM: A Role in Chain-Length Determination for Arginine in the Aspartate-Rich Motifs of Isoprenyl Diphosphate Synthases from .

Molecules 2018 Oct 6;23(10). Epub 2018 Oct 6.

Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA.

Isoprenyl chains are found in many important metabolites. These are derived from precursors of the appropriate length produced by isoprenyl diphosphate synthases (IDSs). The human pathogen makes various isoprenoids/terpenoids, with important roles in their biosynthesis played by two closely related IDSs, encoded by (Rv0562) and (Rv0989c), with Rv0989c generating the 10-carbon precursor ()-geranyl diphosphate (GPP), and Rv0562 the 20-carbon precursor ()-geranylgeranyl diphosphate (GGPP). Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/1420-3049/23/10/2546
Publisher Site
http://dx.doi.org/10.3390/molecules23102546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214179PMC
October 2018
5 Reads

Monitoring of Resistance in Field Populations of Scirtothrips dorsalis (Thysanoptera: Thripidae) and Diaphorina citri (Hemiptera: Liviidae) to Commonly Used Insecticides in Citrus in Central India.

J Econ Entomol 2018 Oct 6. Epub 2018 Oct 6.

Department of Entomology, ICAR-Central Citrus Research Institute, Nagpur, Maharashtra, India.

Field populations of thrips (Scirtothrips dorsalis Hood) from citrus nurseries and psyllids (Diaphorina citri Kuwayama) from commercial citrus orchards of three districts in Maharashtra State in India were evaluated for levels of resistance to organophosphates (acephate, chlorpyrifos, quinalphos, and dimethoate), neonicotinoids (thiamethoxam, imidacloprid), abamectin and spinosad between 2012 and 2017. Leaf dip bioassays for thrips and shoot tip bioassay for nymph and adult psyllids were used to assess levels of insecticide resistance as indicated by resistance ratios (RRs). In general, levels of insecticide resistance were zero (RR = 1) or very low (RR = 2-10); however, we recorded 21. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/jee/advance-article/doi/10.1093/jee
Publisher Site
http://dx.doi.org/10.1093/jee/toy311DOI Listing
October 2018
4 Reads

Characterization of acute intrastriatal effects of paraoxon on in vivo dopaminergic neurotransmission using microdialysis in freely moving rats.

Toxicol Lett 2018 Dec 4;299:124-128. Epub 2018 Oct 4.

Department of Functional Biology and Health Sciences, Faculty of Biology, University of Vigo, Campus Lagoas Marcosende, 36310 Vigo, Spain.

Paraoxon (POX) is an extremely neurotoxic organophosphorous compound (OP) which main toxic mechanism is the irreversible inhibition of cholinesterase. Although the cholinergic system has always been linked as responsible for its acute effects, experimental studies have suggested that the dopaminergic system also may be a potential target for OPs. Based on this, in this study, the acute intrastriatal effects of POX on dopaminergic neurotransmission were characterized in vivo using brain microdialysis in freely moving rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2018.09.017DOI Listing
December 2018
6 Reads

The organophosphate pesticide methamidophos opens the blood-testis barrier and covalently binds to ZO-2 in mice.

Toxicol Appl Pharmacol 2018 Dec 3;360:257-272. Epub 2018 Oct 3.

Department of Physiology, Biophysics and Neuroscience, Cinvestav, Mexico City 07360, Mexico. Electronic address:

Methamidophos (MET) is an organophosphate (OP) pesticide widely used in agriculture in developing countries. MET causes adverse effects in male reproductive function in humans and experimental animals, but the underlying mechanisms remain largely unknown. We explored the effect of MET on mice testes (5 mg/kg/day/4 days), finding that this pesticide opens the blood-testis barrier and perturbs spermatogenesis, generating the appearance of immature germ cells in the epididymis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0041008X183046
Publisher Site
http://dx.doi.org/10.1016/j.taap.2018.10.003DOI Listing
December 2018
2 Reads
3.705 Impact Factor

Size-dependent concentrations and bioaccessibility of organophosphate esters (OPEs) in indoor dust: A comparative study from a megacity and an e-waste recycling site.

Sci Total Environ 2019 Feb 27;650(Pt 2):1954-1960. Epub 2018 Sep 27.

State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.

Indoor dust ingestion is an important pathway in human exposure to environmental pollutants, and the bioaccessibility of pollutants can largely influence human exposure risk assessment. In the present study, the concentrations and compositions of organophosphate esters (OPEs) were investigated for different sizes (50 μm to 2 mm) of indoor dust collected from a megacity, Guangzhou, and an e-waste recycling site. The concentrations of total OPEs were 5360 to 6830 ng/g and 560 to 20,500 ng/g across all sizes of dust from Guangzhou and the e-waste site, respectively. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00489697183380
Publisher Site
http://dx.doi.org/10.1016/j.scitotenv.2018.09.340DOI Listing
February 2019
1 Read

Biological impacts of organophosphates chlorpyrifos and diazinon on development, mitochondrial bioenergetics, and locomotor activity in zebrafish (Danio rerio).

Neurotoxicol Teratol 2018 Nov - Dec;70:18-27. Epub 2018 Oct 2.

Department of Physiological Sciences, Center for Environmental and Human Toxicology, University of Florida Genetics Institute, Interdisciplinary Program in Biomedical Sciences Neuroscience, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA. Electronic address:

The objectives of this study were to compare the biological responses in developing zebrafish to two organophosphate insecticides, chlorpyrifos (CPF) and diazinon (DZN). Zebrafish embryos were exposed to either solvent control (0.1% DMSO, v/v), or one dose of 0. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08920362183011
Publisher Site
http://dx.doi.org/10.1016/j.ntt.2018.10.001DOI Listing
October 2018
2 Reads

Mass spectrometric identification of in vitro-generated metabolites of two emerging organophosphate flame retardants: V6 and BDP.

Chemosphere 2018 Dec 3;212:1047-1057. Epub 2018 Sep 3.

Toxicological Centre, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium. Electronic address:

The aim of the present study was to investigate the in vitro metabolism of two emerging organophosphate flame retardants, namely tetrekis(2-chlorethyl)dichloroisopentyldiphosphate (V6) and bisphenol-A bis-diphenyl phosphate (BDP) in human liver microsomes (HLMs), HLM S9 fractions and in human serum. In particular, the role of cytochrome P450 (CYPs) enzymes and/or paraoxonases (PONs) in the formation of V6 and BDP phase I metabolites was studied. Mono-, di-hydroxylated and hydrolytic phase I metabolites of V6 were mainly formed by CYPs in HLMs, while hydrolytic and O-dealkylated phase I metabolites of BDP were generated by PONs mainly in serum experiments. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00456535183161
Publisher Site
http://dx.doi.org/10.1016/j.chemosphere.2018.08.142DOI Listing
December 2018
3 Reads

Assessment of pattern and outcomes of pesticides poisoning in a tertiary care hospital.

Authors:
A Prashar M Ramesh

Trop Med Int Health 2018 Dec 23;23(12):1401-1407. Epub 2018 Oct 23.

Department of Pharmacy Practice, Maharishi Markandeshwar College of Pharmacy, Mullana (Ambala), India.

Objectives: To assess the socio-demographic profile, pattern and treatment outcomes of pesticides poisoning.

Methods: A prospective observational study was conducted at the department of emergency medicine of a South Indian tertiary care hospital for 1.5 years to study the pattern and outcomes of poisoning cases due to pesticides. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tmi.13156DOI Listing
December 2018
1 Read