28,084 results match your criteria Organophosphates


Synthesis and characterization of a pair of O-/O- 12-P-6 alkyloxaphosphates with a P-O-C-C four-membered ring.

Chem Sci 2019 Mar 19;10(12):3466-3472. Epub 2019 Feb 19.

Department of Chemistry , Graduate School of Science , Hiroshima University , Higashi-hiroshima , 7398526 , Japan . Email:

Structurally characterized hexacoordinate organophosphorus compounds remain rare due to their highly reactive nature and thermal instability. Herein we report the first synthesis of a pair of O-facial and O-meridional hexacoordinate oxaphosphates ( and ) obtained from the O-apical and O-equatorial β-hydroxyalkylphosphoranes and . This was achieved by using the bulky CF-groups on the ortho-substituted aryl backbone. Read More

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http://dx.doi.org/10.1039/c8sc05158eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432329PMC

Comparison of the Respiratory Toxicity and Total Cholinesterase Activities in Dimethyl Versus Diethyl Paraoxon-Poisoned Rats.

Toxics 2019 Apr 16;7(2). Epub 2019 Apr 16.

Département d'Anesthésie⁻Réanimation-SAMU de Paris, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), 75015 Paris, France.

The chemical structure of organophosphate compounds (OPs) is a well-known factor which modifies the acute toxicity of these compounds. We compared ventilation at rest and cholinesterase activities in male Sprague-Dawley rats poisoned with dimethyl paraoxon (DMPO) and diethyl paraoxon (DEPO) at a subcutaneous dose corresponding to 50% of the median lethal dose (MLD). Ventilation at rest was recorded by whole body plethysmography. Read More

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http://dx.doi.org/10.3390/toxics7020023DOI Listing

Quercetin plays protective role in oxidative induced apoptotic events during chronic chlorpyrifos exposure to rats.

J Biochem Mol Toxicol 2019 Apr 16:e22341. Epub 2019 Apr 16.

Department of Biophysics, Panjab University, Chandigarh, India.

Chlorpyrifos (CPF), an organophosphate insecticide has a wider application throughout the world to protect agricultural crops and vegetables from insects. Polyphenolic compounds are considered as beneficial against toxicities induced by organophosphates. The present study was conducted to understand the neuroprotective role of quercetin in chlorpyrifos-induced apoptotic events in rats. Read More

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http://dx.doi.org/10.1002/jbt.22341DOI Listing

Joint probabilistic analysis of risk for aquatic species and exceedence frequency for the agricultural use of chlorpyrifos in the Pampean region, Argentina.

Environ Toxicol Chem 2019 Apr 15. Epub 2019 Apr 15.

Centro de Investigaciones en Toxicología Ambiental y Agrobiotecnología del Comahue (CITAAC), Universidad Nacional del Comahue y CONICET. Buenos Aires 1400, Neuquén, Neuquén, Argentina.

The Pampa Húmeda region in Argentina is characterized by soybean, wheat, and maize production, with intensive application of agrochemicals such as herbicides and insecticides. We used a joint probabilistic approach to analyze the probabilities for environmental chlorpyrifos concentrations measured in the Pampa Húmeda to exceed acute or chronic Hazard Concentration-5 (HC5) values estimated from Species Sensitivity Distributions (SSD) for aquatic species. Chlorpyrifos concentrations in water ranged from 0. Read More

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http://dx.doi.org/10.1002/etc.4441DOI Listing
April 2019
1 Read

Agricultural Exposures and Breast Cancer among Latina in the San Joaquin Valley of California.

J Occup Environ Med 2019 Apr 9. Epub 2019 Apr 9.

University of California, San Francisco, Fresno Medical Education and Research Program (Mills, Shah); University of California, San Francisco, Division of Transplant Surgery (Dodge); and Department of Biology, California State University, Fresno (Bush, Thompson).

Objectives: To assess the role of agricultural work, pesticide exposure and age at first farm labor exposure in breast cancer risk among Hispanic women in Central California.

Methods: A breast cancer (BC) case control study was conducted. Latina BC cases were identified through the California Cancer Registry and controls were recruited. Read More

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http://dx.doi.org/10.1097/JOM.0000000000001598DOI Listing

Characterization and kinetic study of the brain and muscle acetylcholinesterase from Danio rerio.

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 11;222:11-18. Epub 2019 Apr 11.

Federal University of Alagoas, Institute of Chemistry and Biotechnology, Av. Lourival Melo Mota, S/N, Tabuleiro do Martins, Maceió, AL, Brazil.

Acetylcholinesterase (AChE) plays an important role in the therapy of Alzheimer's disease and in the detection of pesticides such as organophosphates which are also widely used in chemical warfare. The aim of this study is the physicochemical and kinetic characterization of brain and muscle ChE from Danio rerio (Zebrafish). Optimal activity was found for brain ChE at alkaline pH 9. Read More

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http://dx.doi.org/10.1016/j.cbpc.2019.04.005DOI Listing

Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase.

Toxicol Appl Pharmacol 2019 Apr 9;372:40-46. Epub 2019 Apr 9.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, USA. Electronic address:

Tabun represents the phosphoramidate class of organophosphates that are covalent inhibitors of acetylcholinesterase (AChE), an essential enzyme in neurotransmission. Currently used therapy in counteracting excessive cholinergic stimulation consists of a muscarinic antagonist (atropine) and an oxime reactivator of inhibited AChE, but the classical oximes are particularly ineffective in counteracting tabun exposure. In a recent publication (Kovarik et al. Read More

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http://dx.doi.org/10.1016/j.taap.2019.04.007DOI Listing

Comparative analyses of the neurobehavioral, molecular, and enzymatic effects of organophosphates on embryo-larval zebrafish (Danio rerio).

Neurotoxicol Teratol 2019 Apr 9;73:67-75. Epub 2019 Apr 9.

Department of Environmental Toxicology, Texas Tech University, Lubbock, TX, 79416, USA.

Organophosphates insecticides (OPs) are common surface water contaminants in both urban and agricultural landscapes. Neurobehavioral effects on larval fish are known to occur at concentrations higher than those reported in the environment. The aim of this study was to perform a comparative analysis of neurobehavioral, molecular, and biochemical responses of four OPs (diazinon, dichlorvos, malathion, methyl-parathion) via the following endpoint measurements: distance traveled, velocity, gene expression (AChE, c-Fos, LINGO-1B, GRIN-1B), enzymatic acetylcholinesterase (AChE) activity, and carboxylesterase (CES) activity. Read More

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http://dx.doi.org/10.1016/j.ntt.2019.04.002DOI Listing
April 2019
2 Reads

Acetylcholinesterase activity in the brain of wild birds in Korea-2014 to 2016.

J Vet Sci 2019 Mar 14;20(2):e9. Epub 2019 Mar 14.

Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.

Acetylcholinesterase (AChE) activity level can be used as a diagnostic marker for anticholinesterase pesticide poisoning. In this study, we aimed to establish a baseline level of normal brain AChE activity in wild birds. AChE activity was measured in the brains of 87dead wild birds (26 species). Read More

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http://dx.doi.org/10.4142/jvs.2019.20.e9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441801PMC

Response to Juberg et al.

Environ Health 2019 04 3;18(1):29. Epub 2019 Apr 3.

Department of Public Health, University of Southern Denmark, Odense, Denmark.

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http://dx.doi.org/10.1186/s12940-019-0466-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446298PMC
April 2019
1 Read

Reactivity and mechanism of α-nucleophile scaffolds as catalytic organophosphate scavengers.

Org Biomol Chem 2019 Apr;17(16):3951-3963

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

Despite their unique benefits imparted by their structure and reactivity, certain α-nucleophile molecules remain underexplored as chemical inactivators for the topical decontamination of reactive organophosphates (OPs). Here, we present a library of thirty α-nucleophile scaffolds, each designed with either a pyridinium aldoxime (PAM) or hydroxamic acid (HA) α-nucleophile core tethered to a polar or charged scaffold for optimized physicochemical properties and reactivity. These library compounds were screened for their abilities to catalyze the hydrolysis of a model OP, paraoxon (POX), in kinetic assays. Read More

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http://xlink.rsc.org/?DOI=C9OB00503J
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http://dx.doi.org/10.1039/c9ob00503jDOI Listing
April 2019
2 Reads

Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north American pooled project.

Environ Int 2019 Mar 27;127:199-205. Epub 2019 Mar 27.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Organophosphates and carbamates have been among the most commonly used insecticides, with both agricultural and residential uses. Previous studies have suggested associations of non-Hodgkin lymphoma (NHL) with some of these chemicals; however, many studies have been limited in their ability to evaluate associations with lymphoma subtypes. We evaluated the use of eleven organophosphate and two carbamate insecticides in association with NHL in the North American Pooled Project, which includes data from case-control studies in the United States and Canada (1690 cases/5131 controls). Read More

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http://dx.doi.org/10.1016/j.envint.2019.03.018DOI Listing
March 2019
4 Reads

Poisoning in Israel: Annual Report of the Israel Poison Information Center, 2017.

Isr Med Assoc J 2019 Mar;21(3):175-182

Maryland Poison Center, Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, MD, USA.

Background: The Israel Poison Information Center (IPIC), Rambam Health Care Campus, provides 24-hour telephone consultations on clinical toxicology and drug and reproductive toxicology. It participates in research, teaching and regulatory activities, and provides laboratory services. In 2014, nurse specialists in poison information joined the IPIC. Read More

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March 2019
1 Read
0.903 Impact Factor

Nanobiotechnology as an emerging approach to combat malaria: A systematic review.

Nanomedicine 2019 Mar 21;18:221-233. Epub 2019 Mar 21.

Infectious and Tropical Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Mosquitoes (Diptera; Culicidae) present a major threat to millions of people and animals worldwide, as they act as vectors for various pathogens, especially parasites and viruses. Resistance to insecticides, such as organophosphates and microbial control agents, and insufficient adherence to application guidelines are common reasons for insecticide treatment failure. Therefore, there is an urgent need for exploration of safer, cheaper, and more effective agents, with novel modes of action, to improve mosquito control. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193004
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http://dx.doi.org/10.1016/j.nano.2019.02.017DOI Listing
March 2019
3 Reads

Degradation of some organophosphorus pesticides in aqueous solution by gamma irradiation.

J Hazard Mater 2019 Mar 4;373:23-28. Epub 2019 Mar 4.

Ministry of Agriculture and Land Reclamation, Agricultural Research Center, Central laboratory of residue analysis of pesticides and heavy metals in food, Giza, Egypt.

This study reviews the effect of different gamma radiation doses (1, 3, 5, 10 and 20 kGy) on the degradation of chlorfenvinphos, diazinon, dimethoate, and profenofos at different concentrations (0.5, 1.0, and 5 μg/mL) in aqueous solutions (deionized, tap, and groundwater). Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.03.011DOI Listing
March 2019
3 Reads

Effects of pesticides on exposure and susceptibility to parasites can be generalised to pesticide class and type in aquatic communities.

Ecol Lett 2019 Mar 21. Epub 2019 Mar 21.

Department of Biological Sciences, Eck Institute for Global Health, and Environmental Change Initiative, University of Notre Dame, Notre Dame, IN, USA.

Pesticide pollution can alter parasite transmission, but scientists are unaware if effects of pesticides on parasite exposure and host susceptibility (i.e. infection risk given exposure) can be generalised within a community context. Read More

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http://dx.doi.org/10.1111/ele.13253DOI Listing
March 2019
2 Reads

Organophosphate flame retardants in college dormitory dust of northern Chinese cities: Occurrence, human exposure and risk assessment.

Sci Total Environ 2019 May 7;665:731-738. Epub 2019 Feb 7.

International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), State Key Laboratory of Urban Water Resource and Environment, and School of Environment, Harbin Institute of Technology, Harbin 150090, China; International Joint Research Center for Arctic Environment and Ecosystem (IJRC-AEE), State Key Laboratory of Urban Water Resource and Environment, and School of Environment, Harbin Institute of Technology, Harbin 150090, China; University Corporation for Polar Research, Beijing 100875, China.

Organophosphate flame retardants (OPFRs) are widely added to consumer products and building materials, which may pose potential health risk to humans. But information on their contamination and human exposure in the indoor environment especially dormitories in northern China is rare. In this study, twelve OPFRs were investigated in college dormitory dust that collected from Harbin, Shenyang, and Baoding, in northern China. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.098DOI Listing

Fabricating an Acetylcholinesterase Modulated UCNPs-Cu Fluorescence Biosensor for Ultrasensitive Detection of Organophosphorus Pesticides-Diazinon in Food.

J Agric Food Chem 2019 Apr 27;67(14):4071-4079. Epub 2019 Mar 27.

School of Food and Biological Engineering , Jiangsu University , Zhenjiang 212013 , China.

In this study, a highly sensitive upconversion fluorescence (FL) biosensor was developed for the detection of organophosphorus pesticides (OPs) based on an acetylcholinesterase (AChE) modulated FL "off-on-off" strategy. The luminescence of synthesized UCNPs could be quenched strongly by Cu due to an energy transfer effect. Upon addition of AChE and acetylthiocholine (ATCh), the enzymatic hydrolysate (thiocholine) could seize Cu from UCNPs-Cu mixture, resulting in the quenched FL triggered on. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b07201DOI Listing
April 2019
2 Reads

Increased Biting Rate of Insecticide-Resistant Culex Mosquitoes and Community Adherence to IRS for Malaria Control in Urban Malabo, Bioko Island, Equatorial Guinea.

J Med Entomol 2019 Mar 18. Epub 2019 Mar 18.

Department of Entomology, Texas A&M University.

Sustaining high levels of indoor residual spraying (IRS) coverage (≥85%) for community protection against malaria remains a challenge for IRS campaigns. We examined biting rates and insecticide resistance in Culex species and Anopheles gambiae s.l. Read More

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http://dx.doi.org/10.1093/jme/tjz025DOI Listing
March 2019
1 Read

Effects of prenatal exposure to temephos on behavior and social interaction.

Neuropsychiatr Dis Treat 2019 11;15:669-673. Epub 2019 Mar 11.

Neurobiology Laboratory of Inflammatory and Metabolic Processes, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil,

The neurodevelopment period is susceptible to alterations by genetic and environmental factors, such as the exposure to organophosphates (OP). The OP is neurotoxic and has been associated with neurological diseases pathophysiology. The OP temephos is widely used against in Brazil's public health programs. Read More

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http://dx.doi.org/10.2147/NDT.S193896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417020PMC
March 2019
1 Read

Toxicokinetic patterns, metabolites formation and distribution in various tissues of the Chinese rare minnow (Gobiocypris rarus) exposed to tri(2‑butoxyethyl) phosphate (TBOEP) and tri-n-butyl phosphate (TNBP).

Sci Total Environ 2019 Jun 6;668:806-814. Epub 2019 Mar 6.

State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Alkylated organophosphate esters (alkyl-OPEs) are widely used and extensively detected in aquatic organisms. This work investigated the tissue-specific toxicokinetics of two common alkyl-OPEs, tri(2‑butoxyethyl) phosphate (TBOEP) and tri‑n‑butyl phosphate (TNBP) in Chinese rare minnow (Gobiocypris rarus) through a 50 day uptake and depuration experiment. The tissue-specific bioconcentration factor (BCF) values for the two alkyl-OPEs ranged from 1 to 30 L/kg wet weight (ww), with the kidney and ovary as the tissues with the highest accumulation. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.038DOI Listing

Deficiency of valencene in mandarin hybrids is associated with a deletion in the promoter region of the valencene synthase gene.

BMC Plant Biol 2019 Mar 13;19(1):101. Epub 2019 Mar 13.

University of Florida, Institute of Food and Agricultural Sciences, Citrus Research and Education Center, Lake Alfred, FL, 33850, USA.

Background: Valencene is a major sesquiterpene in citrus oil and biosynthesized by valencene synthase (Cstps1; EC: 4.2.3. Read More

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http://dx.doi.org/10.1186/s12870-019-1701-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417135PMC
March 2019
1 Read
3.813 Impact Factor

Persistent alterations in seizure susceptibility, drug responsiveness and comorbidities associated with chemical kindling after neonatal exposure to an organophosphate.

Neurotoxicology 2019 Mar 9;73:92-99. Epub 2019 Mar 9.

Department of Biology, College of Science, Shiraz University, Shiraz, Iran. Electronic address:

Developmental exposure to organophosphates (OPs), at doses that do not cause cholinergic crisis, induces profound and lasting alterations in different neurotransmitter systems, which contribute to several behavioral outcomes. The present work examines whether neonatal exposure to low dose of chlorpyrifos (CPF), a widely used OP insecticide, alters the general excitability of the adult brain, its responsiveness to drugs with antiepileptic properties, the process of chemical kindling and the kindling-induced behavioral outcomes. Neonatal rats were exposed to daily doses of CPF (1 mg/kg) or dimethyl sulfoxide (DMSO, vehicle) on postnatal days (PND) 1-4. Read More

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http://dx.doi.org/10.1016/j.neuro.2019.03.002DOI Listing
March 2019
2 Reads

Targeting intracellular calcium stores alleviates neurological morbidities in a DFP-based rat model of Gulf War Illness.

Toxicol Sci 2019 Mar 11. Epub 2019 Mar 11.

Departments of Neurology, Virginia Commonwealth University, Richmond, Virginia, USA.

Gulf War Illness (GWI) is a chronic multi-symptom disorder afflicting the veterans of the First Gulf War, and includes neurological symptoms characterized by depression and memory deficits. Chronic exposure to organophosphates (OP) is considered a leading cause for GWI, yet its pathobiology is not fully understood. We recently observed chronic elevations in neuronal Ca2+ levels ([Ca2+]i) in an OP- diisopropyl fluorophosphate (DFP) based rat model for GWI. Read More

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http://dx.doi.org/10.1093/toxsci/kfz070DOI Listing

Bioremediation of triphenyl phosphate by Brevibacillus brevis: Degradation characteristics and role of cytochrome P450 monooxygenase.

Sci Total Environ 2018 Jun 20;627:1389-1395. Epub 2018 Feb 20.

Key Laboratory of Ministry of Education on Pollution Control and Ecosystem Restoration in Industry Clusters, Guangdong Provincial Engineering and Technology Research Center for Environmental Risk Prevention and Emergency Disposal, School of Environment and Energy, South China University of Technology, Guangzhou 510006, Guangdong, PR China.

Triphenyl phosphate (TPHP) has been detected with increasing frequency in environmental samples, which has aroused great attention regarding its potential adverse effects. In this study, biodegradation of TPHP by Brevibacillus brevis was investigated. The results revealed that the highest degradation efficiency of 3μmol/L TPHP by B. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.02.028DOI Listing

Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication.

Neurotoxicology 2019 Mar 7;73:81-84. Epub 2019 Mar 7.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, 1089 Veterinary Medicine Drive, Davis, CA, 95616, USA. Electronic address:

Acute intoxication with organophosphate cholinesterase inhibitors (OPs) is a significant human health threat, and current medical countermeasures for OP poisoning are of limited therapeutic efficacy. The rat model of acute intoxication with diisopropylfluorophosphate (DFP) is increasingly being used to test candidate compounds for efficacy in protecting against the immediate and long-term consequences of acute OP toxicity. In this model, rats are typically pretreated with pyridostigmine bromide (PB), a reversible cholinesterase inhibitor, to enhance survival. Read More

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http://dx.doi.org/10.1016/j.neuro.2019.03.001DOI Listing
March 2019
1 Read

Pesticide residues in Nepalese vegetables and potential health risks.

Environ Res 2019 Mar 2;172:511-521. Epub 2019 Mar 2.

Soil Physics and Land Management Group, Wageningen University and Research, Wageningen, The Netherlands.

We conducted this study in order to assess the pesticide residues in vegetables and examine the related human health risk. Therefore, residues of 23 pesticides (organophosphates, organochlorines, acaricides, fungicides, and insecticides of biological origin) were analysed in the three main vegetable crops grown in Southern Nepal: 27 eggplant, 27 chilli and 32 tomato samples representing (i) conventional (N = 67) and ii) integrated pest management (IPM) fields (N = 19). Pesticide residues were found in 93% of the eggplant samples and in all of the chilli and tomato samples. Read More

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http://dx.doi.org/10.1016/j.envres.2019.03.002DOI Listing
March 2019
1 Read

A sensitive amperometric AChE-biosensor for organophosphate pesticides detection based on conjugated polymer and Ag-rGO-NH nanocomposite.

Bioelectrochemistry 2019 Jun 13;127:163-170. Epub 2019 Feb 13.

Collaborative Research Center, Shanghai University of Medicine and Health Sciences, Pudong, Shanghai, China. Electronic address:

Long-term accumulation of organophosphate pesticides in environment presents a potential hazard to human and animal health. Towards this, a highly sensitive amperometric AChE-biosensor based on conjugated polymer and Ag-rGO-NH nanocomposite has been successfully developed. First, 4, 7-di (furan-2-yl) benzo thiadiazole (FBThF) was electrochemically polymerized on the electrode surface. Read More

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http://dx.doi.org/10.1016/j.bioelechem.2019.02.003DOI Listing
June 2019
1 Read

Insecticide Toxicity to Drosophila suzukii (Diptera: Drosophilidae) parasitoids: Trichopria anastrephae (Hymenoptera: Diapriidae) and Pachycrepoideus vindemmiae (Hymenoptera: Pteromalidae).

J Econ Entomol 2019 Mar 4. Epub 2019 Mar 4.

Crop Protection Department, Federal University of Pelotas (UFPel) Agronomy School "Eliseu Maciel," PO Box 354, 96010-900, Capão do Leão - RS - Brazil.

Drosophila suzukii (Matsumura) is an important pest of small fruits, which has been causing significant damage to commercial crops in North America, Europe, and South America. This pest is mainly controlled with insecticide applications because of its highly biotic potential and polyphagy. However, studies conducted in crops infested by D. Read More

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https://academic.oup.com/jee/advance-article/doi/10.1093/jee
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http://dx.doi.org/10.1093/jee/toz033DOI Listing
March 2019
6 Reads

Organophosphate ester and phthalate ester metabolites in urine from primiparas in Shenzhen, China: Implications for health risks.

Environ Pollut 2019 Apr 1;247:944-952. Epub 2019 Feb 1.

Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, Guangdong, PR China.

Organophosphate esters (OPEs) and phthalate esters (PAEs) are extensively used as additives in commercial and household products. However, knowledge on human exposure to OPEs and PAEs remains limited in China. This study aimed to investigate OPE and PAE metabolites in urine samples of primiparas and to evaluate the cumulative risk of OPE and PAE exposure. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.107DOI Listing
April 2019
3 Reads

Health risk assessment of pesticide residues in fruits and vegetables from farms and markets of Western Indian Himalayan region.

Authors:
D Kumari S John

Chemosphere 2019 Jun 19;224:162-167. Epub 2019 Feb 19.

Civil Engineering Department, Punjab Engineering College, Chandigarh, India. Electronic address:

The extensive use of pesticides in agriculture has become a very common practice in developing countries like India. Consequently, the increased concentration of residues of these hazardous pesticides in fruits and vegetables is manifested. The study aimed to assess the health hazards associated with the presence of pesticide residues in fruits and vegetables sampled from farms and markets of Kinnaur district of Himachal Pradesh (India). Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.02.091DOI Listing
June 2019
2 Reads

Neuropsychiatric Disorders in Farmers Associated with Organophosphorus Pesticide Exposure in a Rural Village of Northwest México.

Int J Environ Res Public Health 2019 Feb 26;16(5). Epub 2019 Feb 26.

Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Calzada Universidad 14418, Parque Industrial Internacional, Tijuana 22300, Mexico.

This study aims to determine the degree of acetylcholinesterase inhibition and neurological symptoms for each of the psychiatric disorders diagnosed in the farm workers of a rural population in the state of Baja California, Mexico. We conducted a cross-sectional study on 140 agricultural workers (exposed participants). The study was run using the Mini International Neuropsychiatric Interview Diagnostic Test (MINI), a pre-established questionnaire to diagnose the mental state of each agricultural worker. Read More

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http://dx.doi.org/10.3390/ijerph16050689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427808PMC
February 2019
1 Read

Limitations of pesticide genotoxicity testing using the bacterial in vitro method.

Toxicol In Vitro 2019 Jun 23;57:110-116. Epub 2019 Feb 23.

The Federal Budgetary Establishment of Science, «Federal Scientific Center of Hygiene named after F.F. Erisman» of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Semashko Str. 2., Mytishchi 141014, Russian Federation.

The results of genotoxicity assessment of 115 technical grade pesticide products (61 names) with the Ames test and mammalian erythrocyte micronucleus test in vivo are presented. In most cases, unidirectional results were found. However, some pesticides belonging to classes of neonicotinoids, derivatives of phenylurea, glycine and phenoxycarboxylic acids showed genotoxic effects only under in vivo conditions. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.02.018DOI Listing
June 2019
2 Reads

Brain acetylcholinesterase of three perciformes: From the characterization to the in vitro effect of metal ions and pesticides.

Ecotoxicol Environ Saf 2019 May 22;173:494-503. Epub 2019 Feb 22.

Universidade Federal Rural de Pernambuco (UFRPE), Departamento de Pesca e Aquicultura, Recife, Brazil.

Estuarine environments gather pollution from large regions including urban and industrial zones. The monitoring of environmental quality in these areas constitutes a real requirement for global sustainable development. Therefore, the aim of this study was to characterize the physicochemical and kinetic parameters of brain acetylcholinesterase (AChE) in the species Centropomus undecimalis, Diapterus auratus and Diapterus rhombeus and to assess the effects (in vitro) of pesticides and metal ions on their respective activities in order to investigate them as potential biomarkers. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.047DOI Listing
May 2019
1 Read

Cholinesterases characterization of three tropical fish species, and their sensitivity towards specific contaminants.

Ecotoxicol Environ Saf 2019 May 22;173:482-493. Epub 2019 Feb 22.

Departamento de Biologia, Universidade de Aveiro, Centro de Estudos do Ambiente e do Mar (CESAM), Campus de Santiago, 3810-193 Aveiro, Portugal. Electronic address:

Cholinesterases are frequent targets for toxic effects, namely by insecticides derived from phosphoric and carbamic acids. This effects allows the use of cholinesterase inhibition as a biomarker for contamination of aquatic environments by these specific chemical agents. However, cholinesterases are differently responsive to environmental contaminants, according to their different forms and locations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513193013
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http://dx.doi.org/10.1016/j.ecoenv.2019.01.105DOI Listing
May 2019
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Targeting the glutamatergic system to counteract organophosphate poisoning: A novel therapeutic strategy.

Neurobiol Dis 2019 Feb 21. Epub 2019 Feb 21.

Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States of America; Department of Psychiatry, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States of America. Electronic address:

One of the devastating effects of acute exposure to organophosphates, like nerve agents, is the induction of severe and prolonged status epilepticus (SE), which can cause death, or brain damage if death is prevented. Seizures after exposure are initiated by muscarinic receptor hyperstimulation-after inhibition of acetylcholinesterase by the organophosphorus agent and subsequent elevation of acetylcholine-but they are reinforced and sustained by glutamatergic hyperexcitation, which is the primary cause of brain damage. Diazepam is the FDA-approved anticonvulsant for the treatment of nerve agent-induced SE, and its replacement by midazolam is currently under consideration. Read More

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http://dx.doi.org/10.1016/j.nbd.2019.02.017DOI Listing
February 2019

[Susceptibility status of and to Organophosphates and Carbamates in the Agricultural Exploitation Zones of oil Palm at Mouila, Gabon].

Bull Soc Pathol Exot 2018 ;111(3):176-182

Institut de recherche en écologie tropicale (IRET), BP 13354, Libreville, Gabon.

This study was conducted during the rainy season of 2017 in the agricultural areas at Mouila, with the aim to assess the determination of susceptibility of complex to insecticides and the detection of Ace 1 mutation. Mosquito larvae were collected by using the method and nursed to adult stage. The susceptibility of adult populations to organophosphates and carbamates was assessed using the standard WHO susceptibility test protocol. Read More

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http://dx.doi.org/10.3166/bspe-2018-0040DOI Listing
January 2018
2 Reads

High frequencies of F1534C and V1016I mutations and association with pyrethroid resistance in from Somgandé (Ouagadougou), Burkina Faso.

Trop Med Health 2019 4;47. Epub 2019 Jan 4.

Laboratoire d'Entomologie Fondamentale et Appliquée, Université Ouaga 1 JKZ, Ouagadougou, Burkina Faso.

Background: Resistance to pyrethroid insecticides involving mutations is widespread in (L.) (Diptera: Culicidae) and potentially could impact control efforts in endemic countries. Dengue cases had been sporadic in Burkina Faso for over a decade prior to the 2016-2017 outbreak that resulted in 15,074 suspected cases and 36 deaths, mainly in Ouagadougou. Read More

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http://dx.doi.org/10.1186/s41182-018-0134-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318976PMC
January 2019

H NMR-based metabolomic analysis of nine organophosphate flame retardants metabolic disturbance in Hep G2 cell line.

Sci Total Environ 2019 May 4;665:162-170. Epub 2019 Feb 4.

Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, China. Electronic address:

Organophosphate flame retardants (OPFRs) are frequently found in the environment and could be adversely affecting organisms. In fact, nine OPFRs have been shown to cause endocrine disruptions, but information on the metabolism-perturbing properties of these OPFRs remains unclear. In this study, the H-nuclear magnetic resonance (NMR) based metabolomic method was applied to evaluate the metabolic disturbances caused by these nine OPFRs. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.055DOI Listing
May 2019
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Mass spectrometry based proteomic approach for the screening of butyrylcholinesterase adduct formation with organophosphates.

Talanta 2019 May 16;197:374-382. Epub 2019 Jan 16.

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency, St. Petersburg, Russian Federation.

Organophosphates' toxic effect causes covalent binding to serine-198 in the active site of human plasma butyrylcholinesterase (BChE) with loss of enzymatic function (covalent inhibition). Mass spectrometric detection of modified FGESAGAAS peptide at the active site is a powerful exposure biomarker tool. The aim of this study was to develop mass spectrometry-based method for BChE adduct formation screening, avoiding the use of standard peptides. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.059DOI Listing

Direct, selective and ultrasensitive electrochemical biosensing of methyl parathion in vegetables using Burkholderia cepacia lipase@MOF nanofibers-based biosensor.

Talanta 2019 May 14;197:356-362. Epub 2019 Jan 14.

Department of Food Science and Engineering, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315211, China. Electronic address:

Methyl parathion is one of the most widely used pesticides in agricultural practices. It caused accumulation of acetylcholine and over-stimulation of receptors in synapses which eventually led to damage of the nervous system. Present study developed a direct, sensitive, rapid and reliable method for methyl parathion residues detection in vegetable samples. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00399140193005
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http://dx.doi.org/10.1016/j.talanta.2019.01.052DOI Listing
May 2019
1 Read
3.545 Impact Factor

Determination of alkaline phosphatase activity based on enzyme-triggered generation of a thiol and the fluorescence quenching of silver nanoclusters.

Mikrochim Acta 2019 02 15;186(3):180. Epub 2019 Feb 15.

The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren'ai Road, Industrial Park, Suzhou, 215123, China.

A fluorimetric method is described for the determination of alkaline phosphatase (ALP) activity. It is based on the use of polyethyleneimine-coated silver nanoclusters (AgNCs), which display an intense blue fluorescence peaking at 450 nm (under 375 nm excitation). ALP catalyzes the dephosphorylation of the thiophosphate amifostine to generate a thiol that binds to the AgNCs and causes its fluorescence to be quenched. Read More

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http://link.springer.com/10.1007/s00604-019-3301-4
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http://dx.doi.org/10.1007/s00604-019-3301-4DOI Listing
February 2019
6 Reads

Effect of microplastics on the toxicity of chlorpyrifos to the microalgae Isochrysis galbana, clone t-ISO.

Ecotoxicol Environ Saf 2019 May 12;173:103-109. Epub 2019 Feb 12.

Spanish Institute of Oceanography, IEO, Oceanographic Center of Murcia, Varadero 1, E-30740 San Pedro del Pinatar, Murcia, Spain. Electronic address:

It is highly likely that phytoplanktonic organisms will interact with MPs in the ocean, and consequently with the pollutants sorbed onto their surfaces. Microalgae play an essential role in maintaining the balance of the marine ecosystem due to the fact that they are a primary producer and the base of marine trophic chains. Therefore, their fitness represents an important index in the assessment of water quality. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.020DOI Listing
May 2019
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Resistance development and insecticide susceptibility in , an important vector of human diseases, against selection pressure of temephos and its relationship to cross-resistance towards organophosphates and pyrethroids insecticides.

Afr Health Sci 2018 Dec;18(4):1175-1181

Laboratory of Genetics, Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia.

Background: is an important vector of human diseases.

Objective: To determine the insecticide resistance development in against selection pressure of temephos.. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354882PMC
December 2018

Transcriptional response of ATP-binding cassette (ABC) transporters to insecticides in the cotton bollworm, Helicoverpa armigera.

Pestic Biochem Physiol 2019 Feb 21;154:46-59. Epub 2018 Dec 21.

Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China. Electronic address:

When any living organism is frequently exposed to any drugs or toxic substances, they evolve different detoxification mechanism to confront with toxicants during absorption and metabolism. Likewise, the insects have evolved detoxification mechanisms as they are frequently exposed to different toxic secondary plant metabolites and commercial insecticides. ABC transporter superfamily is one of the largest and ubiquitous group of proteins which play an important role in phase III of the detoxification process. Read More

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http://dx.doi.org/10.1016/j.pestbp.2018.12.007DOI Listing
February 2019
2 Reads
2.014 Impact Factor

Plant allelochemicals affect tolerance of polyphagous lepidopteran pest Helicoverpa armigera (Hübner) against insecticides.

Pestic Biochem Physiol 2019 Feb 18;154:32-38. Epub 2018 Dec 18.

Key Laboratory of Ministry of Education for Genetics, Breeding and Multiple Utilization of Crops, College of Crop Science, Fujian Agriculture and Forestry University, Jinshan, Fuzhou 350002, China. Electronic address:

Cotton bollworm, Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae), is a polyphagous lepidopteran pest distributed worldwide with a broad spectrum of host plants. However, the mechanism of H. armigera adaptation to various insecticides and defensive allelochemicals in its host plants is not fully understood. Read More

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http://dx.doi.org/10.1016/j.pestbp.2018.12.009DOI Listing
February 2019
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Chlorpyrifos stimulates expression of vitamin D receptor in skin cells irradiated with UVB.

Pestic Biochem Physiol 2019 Feb 12;154:17-22. Epub 2018 Dec 12.

Institute of Rural Health, Department of Molecular Biology and Translational Research, Lublin, Poland; University of Information Technology and Management, Department of Medical Biology and Translational Research, Rzeszow, Poland. Electronic address:

Skin, the organ responsible for vitamin D synthesis, is fully exposed to many xenobiotics, e.g. polycyclic aromatic hydrocarbons and pesticides. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00483575183052
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http://dx.doi.org/10.1016/j.pestbp.2018.12.003DOI Listing
February 2019
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Neuro-protective potential of quercetin during chlorpyrifos induced neurotoxicity in rats.

Drug Chem Toxicol 2019 Mar 12;42(2):220-230. Epub 2019 Feb 12.

a Department of Biophysics , Panjab University , Chandigarh , India.

Chlorpyrifos (CPF) has been considered as one of the most potent organophosphates and is linked to several neurological disorders. On the other hand, Quercetin is a vital plant flavanoid and has been reported to regulate a number of physiological processes in the central nervous system. The present study was conducted to investigate the protective potential of quercetin during chlorpyrifos induced neurotoxicity. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2019.1
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http://dx.doi.org/10.1080/01480545.2019.1569022DOI Listing
March 2019
6 Reads