27,908 results match your criteria Organophosphates


Mass spectrometry based proteomic approach for the screening of butyrylcholinesterase adduct formation with organophosphates.

Talanta 2019 May 16;197:374-382. Epub 2019 Jan 16.

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency, St. Petersburg, Russian Federation.

Organophosphates' toxic effect causes covalent binding to serine-198 in the active site of human plasma butyrylcholinesterase (BChE) with loss of enzymatic function (covalent inhibition). Mass spectrometric detection of modified FGESAGAAS peptide at the active site is a powerful exposure biomarker tool. The aim of this study was to develop mass spectrometry-based method for BChE adduct formation screening, avoiding the use of standard peptides. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.059DOI Listing

Resistance development and insecticide susceptibility in , an important vector of human diseases, against selection pressure of temephos and its relationship to cross-resistance towards organophosphates and pyrethroids insecticides.

Afr Health Sci 2018 Dec;18(4):1175-1181

Laboratory of Genetics, Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia.

Background: is an important vector of human diseases.

Objective: To determine the insecticide resistance development in against selection pressure of temephos.. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354882PMC
December 2018

Neuro-protective potential of quercetin during chlorpyrifos induced neurotoxicity in rats.

Drug Chem Toxicol 2019 Feb 12:1-11. Epub 2019 Feb 12.

a Department of Biophysics , Panjab University , Chandigarh , India.

Chlorpyrifos (CPF) has been considered as one of the most potent organophosphates and is linked to several neurological disorders. On the other hand, Quercetin is a vital plant flavanoid and has been reported to regulate a number of physiological processes in the central nervous system. The present study was conducted to investigate the protective potential of quercetin during chlorpyrifos induced neurotoxicity. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2019.1
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http://dx.doi.org/10.1080/01480545.2019.1569022DOI Listing
February 2019
5 Reads

Target-site mutations (AChE-G119S and kdr) in Guangxi Anopheles sinensis populations along the China-Vietnam border.

Parasit Vectors 2019 Feb 7;12(1):77. Epub 2019 Feb 7.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

Background: In South Asia, the epidemiology of malaria is complex, and transmission mainly occurs in remote areas near international borders. Vector control has been implemented as a key strategy in malaria prevention for decades. A rising threat to the efficacy of vector control efforts is the development of insecticide resistance, thus it is important to monitor the type and frequency of insecticide resistant alleles in the disease vectors such as An. Read More

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http://dx.doi.org/10.1186/s13071-019-3298-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367790PMC
February 2019

Occurrence of organophosphate flame retardants in farmland soils from Northern China: Primary source analysis and risk assessment.

Environ Pollut 2019 Jan 29;247:832-838. Epub 2019 Jan 29.

MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin, 300071, China.

Ninety-eight soil samples were collected from farmland soils from Beijing-Tianjin-Hebei core area, Northern China, where agricultural lands were subjected to contamination from intense urban and industrial activities. Twelve organophosphates flame retardants (OPFRs) were analyzed with total soil concentrations ranging from 0.543 μg/kg to 54. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491183532
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http://dx.doi.org/10.1016/j.envpol.2019.01.036DOI Listing
January 2019
6 Reads

Transition State Analysis of the Reaction Catalyzed by the Phosphotriesterase from Sphingobium sp. TCM1.

Biochemistry 2019 Feb 19. Epub 2019 Feb 19.

Department of Chemistry , Texas A&M University , College Station , Texas 77843 , United States.

Organophosphorus flame retardants are stable toxic compounds used in nearly all durable plastic products and are considered major emerging pollutants. The phosphotriesterase from Sphingobium sp. TCM1 ( Sb-PTE) is one of the few enzymes known to be able to hydrolyze organophosphorus flame retardants such as triphenyl phosphate and tris(2-chloroethyl) phosphate. Read More

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http://dx.doi.org/10.1021/acs.biochem.9b00041DOI Listing
February 2019
3.015 Impact Factor

Mechanism Underlying Organophosphate Paraoxon-Induced Kinetic Tremor.

Neurotox Res 2019 Feb 7. Epub 2019 Feb 7.

Department of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan.

Organophosphates (OPs) inhibit cholinesterase and hyperactivate the acetylcholinergic nervous system in the brain, causing motor disorders (e.g., tremor and seizures). Read More

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http://dx.doi.org/10.1007/s12640-019-0007-7DOI Listing
February 2019
1 Read
3.538 Impact Factor

Trends and Perspectives in Immunosensors for Determination of Currently-Used Pesticides: The Case of Glyphosate, Organophosphates, and Neonicotinoids.

Biosensors (Basel) 2019 Feb 4;9(1). Epub 2019 Feb 4.

Dipartimento di Chimica, Università degli Studi di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino (Fi), Italy.

Pesticides, due to their intensive use and their peculiar chemical features, can persist in the environment and enter the trophic chain, thus representing an environmental risk for the ecosystems and human health. Although there are several robust and reliable standard analytical techniques for their monitoring, the high frequency of contamination caused by pesticides requires methods for massive monitoring campaigns that are capable of rapidly detecting these compounds in many samples of different origin. Immunosensors represent a potential tool for simple, rapid, and sensitive monitoring of pesticides. Read More

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http://dx.doi.org/10.3390/bios9010020DOI Listing
February 2019

Cotton functionalized with nanostructured TiO-Ag-AgBr layer for solar photocatalytic degradation of dyes and toxic organophosphates.

Int J Biol Macromol 2019 Feb 1. Epub 2019 Feb 1.

CQFM-Centro de Química-Física Molecular and IN-Institute for Nanosciences and Nanotechnologies, IBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal.

The functionalization of cotton fabric with photoactive TiO-Ag-AgBr nanostructured layer has been successfully developed using a low temperature non-aqueous sol-gel route and aqueous suspension of AgBr. Evidence for the growth of TiO layer and the immobilization of AgBr nanoparticles have been confirmed by Raman, XRD and XPS. GSDR analysis revealed a strong absorption in the visible region brought by surface Plasmon resonance (SPR) of Ag nanocrystals generated at the surface of AgBr. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.218DOI Listing
February 2019

The Preferable Binding Pose of Canonical Butyrylcholinesterase Substrates Is Unproductive for Echothiophate.

Acta Naturae 2018 Oct-Dec;10(4):121-124

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Miklukho-Maklaya Str., 16/10, Moscow, 117997, Russia.

In this paper, we, for the first time, describe the interaction between the butyrylcholinesterase enzyme and echothiophate, a popular model compound and an analogue of the chemical warfare agents VX and VR, at the atomistic level. Competition between the two echothiophate conformations in the active site was found using molecular modeling techniques. The first one is close to the mode of binding of the substrates of choline series (butyrylcholine and butyrylthiocholine) and is inhibitory, since it is unable to react with the enzyme. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351040PMC
February 2019

The crystal structure of the phosphotriesterase from M. tuberculosis, another member of phosphotriesterase-like lactonase family.

Biochem Biophys Res Commun 2019 Mar 28;510(2):224-229. Epub 2019 Jan 28.

College of Life Sciences, Nankai University, Tianjin, 30071, China.

Organophosphates (OPs) have been used widely as insecticides for protecting the agricultural crops from the pests. These compounds are highly toxic because they can cause the irreversible damage to human nervous system. Phosphotriesterases (PTEs), widely exist in many different kinds of bacteria, insects and mammals, can hydrolyze phosphotriesters (one major kind of OP) sufficiently. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.01.069DOI Listing
March 2019
1 Read

Photothermally Enhanced Detoxification of Chemical Warfare Agent Simulants Using Bioinspired Core-Shell Dopamine-Melanin@Metal-Organic Frameworks and Their Fabrics.

ACS Appl Mater Interfaces 2019 Feb 7. Epub 2019 Feb 7.

National Engineering Research Center for Colloidal Materials and School of Chemistry and Chemical Engineering , Shandong University , 250100 Jinan , China.

Self-detoxifying materials capable of both capture and destruction of chemical warfare agents (CWAs) are highly desirable for efficient personal protection and safe handling of contaminated materials. Developing new strategies to improve CWA removal efficiency of these materials is highly relevant to CWA purification technology. Herein, we present novel photothermally enhanced catalytic detoxification of CWA simulants and its application in self-detoxifying gas filters. Read More

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http://pubs.acs.org/doi/10.1021/acsami.8b19445
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http://dx.doi.org/10.1021/acsami.8b19445DOI Listing
February 2019
4 Reads

Prophylactic potential of memantine against soman poisoning in rats.

Toxicology 2019 Jan 22;416:62-74. Epub 2019 Jan 22.

Department of Anatomy and Forensic Medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

Background: Carbamates physostigmine and pyridostigmine have been used as a pretreatment against poisoning with nerve agents in order to reversibly inhibit and thus protect from irreversible inhibition a portion of acetylcholinesterase (AChE) in brain and respiratory muscles that is crucial for survival. Memantine, an adamantine derivative, has emerged as a promising alternative to carbamates, since it prevented the fasciculations and skeletal muscle necrosis induced by carbamates and organophosphates, including nerve agents.

Aim: This experimental study was undertaken in order to investigate and compare the protective and behavioural effects of memantine and standard carbamates physostigmine and pyridostigmine in rats poisoned with soman and treated with atropine, oxime HI-6 and diazepam. Read More

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http://dx.doi.org/10.1016/j.tox.2019.01.012DOI Listing
January 2019
5 Reads

Characteristics and mechanisms of chlorpyrifos and chlorpyrifos-methyl adsorption onto biochars: Influence of deashing and low molecular weight organic acid (LMWOA) aging and co-existence.

Sci Total Environ 2019 Mar 4;657:953-962. Epub 2018 Dec 4.

Institute of Environmental Processes and Pollution Control, and School of Environmental and Civil Engineering, Jiangnan University, Wuxi 214122, China. Electronic address:

The effects of inherent minerals in biochars and low molecular weight organic acids (LMWOAs) on chlorpyrifos and chlorpyrifos-methyl adsorption by biochars are unclear. We examined the sorption of chlorpyrifos and chlorpyrifos-methyl onto giant reed-derived biochars before and after deashing or LMWOA aging. The effect of citric acid (CA) as a co-solute on the sorption of chlorpyrifos and chlorpyrifos-methyl was also investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697183485
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http://dx.doi.org/10.1016/j.scitotenv.2018.12.018DOI Listing
March 2019
2 Reads

Microfluidic-based graphene field effect transistor for femtomolar detection of chlorpyrifos.

Sci Rep 2019 Jan 22;9(1):276. Epub 2019 Jan 22.

DBT-National Institute of Animal Biotechnology (DBT-NIAB), Hyderabad, 500032, Telangana, India.

Chlorpyrifos is one of the most widely used pesticides that acts on the nervous system by inhibiting acetylcholinesterase. Prolonged use of chlorpyrifos causes severe neurological, autoimmune, and persistent developmental disorders in humans. Therefore, in this study, a highly sensitive and robust biosensor platform was devised by fabricating graphene field effect transistors (graFET) on Si/SiO substrate for the detection of chlorpyrifos in real samples. Read More

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http://dx.doi.org/10.1038/s41598-018-36746-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343030PMC
January 2019

Method Validation and simultaneous quantification of eight organochlorines/organophosphates in apple by gas chromatography.

J Sci Food Agric 2019 Jan 21. Epub 2019 Jan 21.

Research Centre for Residue and Quality Analysis, Sher-e-Kashmir University of Agricultural Sciences and Technology (SKUAST-K), Shalimar Campus, Srinagar 190025 J&K, India.

Background: The increasing and extensive use of pesticides worldwide has resulted in the significant loss to the non target population particularly humans by directly or indirectly exposures. Also various methods were used for the estimation of pesticide residues in fruits and vegetables from recent past which are either tedious, time consuming or expensive. Therefore the presented studies were performed to determine the pesticides residues from apple by simple and novel validated gas chromatography. Read More

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http://dx.doi.org/10.1002/jsfa.9599DOI Listing
January 2019
1.714 Impact Factor

A systematic review: Impact of endocrine disrupting chemicals exposure on fecundity as measured by time to pregnancy.

Environ Res 2019 Apr 28;171:119-133. Epub 2018 Dec 28.

School of Public Health and Social Work, Queensland University of Technology, QLD, Australia; Institute of Health and Biomedical Innovation, Queensland University of Technology, QLD, Australia.

Background: Emerging scientific evidence suggests that exposure to environmental pollutants is associated with negative effects on fecundity as measured by time to pregnancy (TTP).

Objectives: To conduct a systematic review of the literature on the association between selected endocrine disrupting chemicals (EDCs), and fecundity as measured by TTP in humans. Compounds included in this review are: brominated flame retardants (BFRs) such as hexabromocyclododecane, tetrabromobiphenol A and polybrominated diphenyl ethers; organophosphates flame retardants (OPFRs); and phthalates. Read More

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http://dx.doi.org/10.1016/j.envres.2018.12.065DOI Listing
April 2019
2 Reads

Downregulation of carboxylesterase contributes to cyflumetofen resistance in Tetranychus cinnabarinus (Boisduval).

Pest Manag Sci 2019 Jan 17. Epub 2019 Jan 17.

Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing, 400716, China.

Background: Increased expression or point mutations of carboxyl/cholinesterases (CCEs) have been involved in many cases of insecticides and acaricides resistance. However, it is only rarely documented that down-regulation of CCE genes are associated with resistance, although many insecticides and acaricides need hydrolytic activation in vivo. Previously, expression analysis of a laboratory selected cyflumetofen resistant strain of Tetranychus cinnabarinus indicated that resistance was associated with increased expression of a CCE gene of TcCCE04, but also the down-regulation of two CCE genes, TcCCE12 and TcCCE23. Read More

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http://doi.wiley.com/10.1002/ps.5339
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http://dx.doi.org/10.1002/ps.5339DOI Listing
January 2019
4 Reads

An amino-modified metal-organic framework (type UiO-66-NH) loaded with cadmium(II) and lead(II) ions for simultaneous electrochemical immunosensing of triazophos and thiacloprid.

Mikrochim Acta 2019 01 11;186(2):101. Epub 2019 Jan 11.

Institute of Pesticide and Environmental Toxicology, Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Inserts, Zhejiang University, Hangzhou, 310029, People's Republic of China.

A method is described for simultaneous voltammetric determination of the pesticides triazophos (TRS) and thiacloprid (THD). A glassy carbon electrode (GCE) was modified with a metal-organic framework (type UiO-66-NH) which has a large specific surface (1018 m·g) and contains large amounts of Cd(II) and Pb(II) ions, with adsorption capacities of 230 and 271 mg·g, respectively. The antigen-loaded particles were then bound to antibody, magnetically separated, and analyzed by square wave voltammetry to give signals for Cd(II) and Pb(II) at -0. Read More

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http://dx.doi.org/10.1007/s00604-018-3201-zDOI Listing
January 2019

Fluorometric determination of pesticides and organophosphates using nanoceria as a phosphatase mimic and an inner filter effect on carbon nanodots.

Mikrochim Acta 2019 01 9;186(2):66. Epub 2019 Jan 9.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China.

Nanoceria with a remarkable phosphatase mimicking activity was synthesized and used to catalyze the hydrolysis of phosphate esters in pH 10 solution. The catalytic effect of nanoceria was firstly investigated by selecting p-nitrophenyl phosphate as a model substrate. The pH value, incubation temperature, reaction time, and concentration of nanoceria were optimized. Read More

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http://link.springer.com/10.1007/s00604-018-3175-x
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http://dx.doi.org/10.1007/s00604-018-3175-xDOI Listing
January 2019
9 Reads

Longitudinal, Seasonal, and Occupational Trends of Multiple Pesticides in House Dust.

Environ Health Perspect 2019 01;127(1):17003

Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, Washington, USA.

Background: Children are especially vulnerable to pesticide exposure and can suffer lasting health effects. Because children of farmworkers are exposed to a variety of pesticides throughout development, it is important to explore temporal patterns of coexposures.

Objectives: The objectives of this study were to characterize the pesticide co-exposures, determine how they change over time, and assess differences between farmworker and nonfarmworker households. Read More

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http://dx.doi.org/10.1289/EHP3644DOI Listing
January 2019
1 Read

Susceptibility to common insecticides and detoxifying enzyme activities in Anopheles sundaicus (sensu lato) after cessation of indoor residual spraying of insecticides in the Jaffna Peninsula and its surroundings in northern Sri Lanka.

Parasit Vectors 2019 Jan 7;12(1):13. Epub 2019 Jan 7.

Department of Zoology, Faculty of Science, University of Jaffna, Jaffna, Sri Lanka.

Background: Sri Lanka has been malaria-free since 2013 but re-introduction of malaria transmission by infected overseas travelers is possible due to a prevalence of potent malaria vectors. Knowledge of the insecticide resistance status among Anopheles vectors is important if vector control has to be reintroduced in the island. The present study investigated the insecticide susceptibility levels and resistance mechanisms of Anopheles sundaicus (sensu lato) (previously classified as Anopheles subpictus species B) an important malaria vector in the Jaffna Peninsula and it surroundings in northern Sri Lanka after indoor residual spraying of insecticides was terminated in 2013. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-018-3254-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323756PMC
January 2019
1 Read

Malathion-filled trilayer polyolefin film for malaria vector control.

Mater Sci Eng C Mater Biol Appl 2019 Mar 27;96:419-425. Epub 2018 Nov 27.

SARChI Chair in Carbon Technology and Materials, Institute of Applied Materials, Department of Physics, University of Pretoria, Private Bag X20, Hatfield 0028, Pretoria, South Africa.

The emergence of pyrethroid resistance in mosquitoes is complicating malaria elimination efforts in Africa and alternative insecticides have to be considered for indoor residual spray. Unfortunately, the high volatility of WHO-approved organophosphate alternatives, e.g. Read More

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http://dx.doi.org/10.1016/j.msec.2018.11.057DOI Listing

Studies on the ameliorative effect of curcumin on carbofuran induced perturbations in the activity of lactate dehydrogenase in wistar rats.

Saudi J Biol Sci 2018 Dec 11;25(8):1585-1592. Epub 2016 Mar 11.

Department of Biochemistry, University of Allahabad, Allahabad 211002, India.

Carbofuran is known to inhibit neurotransmission system of insects. The present study was undertaken to evaluate the possible ameliorative effect of curcumin on carbofuran induced alterations in energy metabolism in brain and liver of rats. The results demonstrate that carbofuran caused a significant inhibition of lactate dehydrogenase (LDH) activity in rat liver but an increase in LDH activity in the brain. Read More

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http://dx.doi.org/10.1016/j.sjbs.2016.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303160PMC
December 2018
1 Read

Cholinesterases and Engineered Mutants for the Detection of Organophosphorus Pesticide Residues.

Sensors (Basel) 2018 Dec 5;18(12). Epub 2018 Dec 5.

Hubei Key Laboratory of Wudang Local Chinese Medicine Research, School of Pharmacy, Hubei University of Medicine, Shiyan 442000, China.

Nowadays, pesticide residues constitute an increasing public health concern. Cholinesterases, acetylcholinesterase, and butyrylcholinesterase, are reported to be involved in detoxification processes owing to their capability of scavenging organophosphates and carbamates. Thus, these enzymes are targeted for the discovery of sensors aiming at detecting pesticide residues. Read More

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http://dx.doi.org/10.3390/s18124281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312092PMC
December 2018
2 Reads

Mechanisms of pyrethroid resistance in Aedes (Stegomyia) aegypti from Colombia.

Acta Trop 2019 Mar 12;191:146-154. Epub 2018 Dec 12.

Centro Internacional de Entrenamiento e Investigaciones Médicas CIDEIM, Carrera 125 N 19-225, Cali, Colombia; Universidad ICESI, Calle 18 N 122-135, Cali, Colombia. Electronic address:

In Colombia Aedes (Stegomyia) aegypti is the main vector of urban arboviruses such as dengue, chikungunya and Zika. This urban mosquito has a well-established capacity to develop insecticide resistance to different types of insecticides (pyrethroids, organochlorides, organophosphates), using multiple resistance mechanisms. An understanding of ongoing resistance mechanisms is critical to determining the activities of vector control programs. Read More

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http://dx.doi.org/10.1016/j.actatropica.2018.12.021DOI Listing
March 2019
4 Reads

Simultaneous Quantitation of Isoprenoid Pyrophosphates in Plasma and Cancer Cells Using LC-MS/MS.

Molecules 2018 Dec 11;23(12). Epub 2018 Dec 11.

Department of Pharmacy Practice, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Isoprenoids (IsoP) are an important class of molecules involved in many different cellular processes including cholesterol synthesis. We have developed a sensitive and specific LC-MS/MS method for the quantitation of three key IsoPs in bio-matrices, geranyl pyrophosphate (GPP), farnesyl pyrophosphate (FPP), and geranylgeranyl pyrophosphate (GGPP). LC-MS/MS analysis was performed using a Nexera UPLC System connected to a LCMS-8060 (Shimadzu Scientific Instruments, Columbia, MD) with a dual ion source. Read More

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http://dx.doi.org/10.3390/molecules23123275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321327PMC
December 2018
1 Read
2.416 Impact Factor

Rate constants for the reaction of hydroxyl and sulfate radicals with organophosphorus esters (OPEs) determined by competition method.

Ecotoxicol Environ Saf 2019 Apr 7;170:300-305. Epub 2018 Dec 7.

School of Environment and Energy, South China University of Technology, Guangzhou 510006, China; The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters, Ministry of Education, Guangzhou 510006, China.

Advanced oxidation processes (AOPs), such as hydroxyl radical (•OH) and sulfate radical (•SO) mediated oxidation, are proved to be effective methods to remove the organophosphorus esters (OPEs) in wastewater effluents. However, few studies have reported about the bimolecular reaction rate constants between free radicals (•OH and •SO) and OPEs. This issue was solved by selecting three OPEs as model compounds, the oxidation of these OPEs in UV/HO and UV/KSO process were studied. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.11.142DOI Listing
April 2019
1 Read

Oxidative degradation of chlorpyrifos using ferrate(VI): Kinetics and reaction mechanism.

Ecotoxicol Environ Saf 2019 Apr 6;170:259-266. Epub 2018 Dec 6.

State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, Jiangsu, PR China.

In this study, we investigated the degradation kinetics of chlorpyrifos, an organophosphorus (OP) compound, using ferrate(VI), and investigated the potential of this iron-based chemical oxidant on chlorpyrifos removal from water and wastewater treatments. A series of kinetic experiments were conducted to evaluate the influence of various environmental factors, such as pH, oxidant dosages, as well as the presence of anions, cations, humic acid (HA), and different water matrices. Chlorpyrifos was completely removed within 300 s under the following optimum conditions: [chlorpyrifos] = 1 μM, [Fe(VI)]:[chlorpyrifos] = 100:1, T = 25 °C, and pH = 7. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.11.132DOI Listing

Seasonal variations of tris (2-chloroethyl) phosphate and cytotoxicity of organic extracts in water samples from Wuhan, China.

J Environ Sci (China) 2019 Feb 23;76:299-309. Epub 2018 May 23.

Department of Occupational and Environmental Health, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Tris (2-chloroethyl) phosphate (TCEP) is a typical phosphate flame retardant. Its potential adverse health effects have recently aroused concern. We investigated the seasonal variations of TCEP concentrations in the raw, finished and tap water samples from two drinking water treatment plants (DWTPs) in China, and evaluated the cytotoxicity and apoptosis/necrosis of organic extracts (OEs) in water samples. Read More

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http://dx.doi.org/10.1016/j.jes.2018.05.013DOI Listing
February 2019
2 Reads

Organophosphate flame retardants in leachates from six municipal landfills across China.

Chemosphere 2019 Mar 28;218:836-844. Epub 2018 Nov 28.

School of Environment, State Key Joint Laboratory of Environmental Simulation and Pollution Control (SKLESPC), Beijing Key Laboratory for Emerging Organic Contaminants Control, Tsinghua University, Beijing, 100084, China.

With the phasing out of brominated flame retardants, organophosphate flame retardants (OPFRs) have been widely used and further detected in multiple environmental media. However, municipal landfill leachates, an important source of contamination of OPFRs to aquatic environment, have not been fully understood, especially in a developing country like China. Thus, the occurrence, aqueous removal efficiency, environmental emission, and risk assessment of 10 OPFRs were investigated in leachates from six municipal landfills across China. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.11.150DOI Listing
March 2019
1 Read

Reusable Enzymatic Fiber Mats for Neurotoxin Remediation in Water.

ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.

Highly effective and reusable organophosphorus hydrolase (OPH)-loaded fiber mats have been fabricated that are capable of degrading toxic organophosphates (OPs) over a broad range of relevant concentrations (from 8 ppm to 8,250 ppm). The inherent fragility of enzymes, a major impediment in their incorporation into technologically-relevant materials, was overcome while retaining their high catalytic efficiency, selectivity and sensitivity via a random heteropolymers (RHP) approach. Kinetic analysis guides the design of polycaprolactone matrix morphology from films to fibers, facilitating substrate diffusion in the material. Read More

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http://dx.doi.org/10.1021/acsami.8b18484DOI Listing
December 2018
1 Read

Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus.

J Mol Neurosci 2019 Feb 4;67(2):227-234. Epub 2018 Dec 4.

Department of Neurology, The Chaim Sheba Medical Center, Tel HaShomer, 52621, Ramat Gan, Israel.

Organophosphates (OP) are a major threat to the health of soldiers and civilians due to their use as chemical weapons in war and in terror attacks. Among the acute manifestations of OP poisoning, status epilepticus (SE) is bearing the highest potential for long-term damages. Current therapies do not prevent brain damage and seizure-related brain injuries in OP-exposed humans. Read More

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http://link.springer.com/10.1007/s12031-018-1228-6
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http://dx.doi.org/10.1007/s12031-018-1228-6DOI Listing
February 2019
4 Reads

Chlorpyrifos- and Dichlorvos-Induced Oxidative and Neurogenic Damage Elicits Neuro-Cognitive Deficits and Increases Anxiety-Like Behavior in Wild-Type Rats.

Toxics 2018 Dec 1;6(4). Epub 2018 Dec 1.

Neuroscience Unit, Department of Anatomy, College of Health Sciences, University of Ilorin, P.M.B 1515, Ilorin 240003, Nigeria.

The execution of agricultural activities on an industrial scale has led to indiscriminate deposition of toxic xenobiotics, including organophosphates, in the biome. This has led to intoxication characterized by deleterious oxidative and neuronal changes. This study investigated the consequences of oxidative and neurogenic disruptions that follow exposure to a combination of two organophosphates, chlorpyrifos (CPF) and dichlorvos (DDVP), on neuro-cognitive performance and anxiety-like behaviors in rats. Read More

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http://www.mdpi.com/2305-6304/6/4/71
Publisher Site
http://dx.doi.org/10.3390/toxics6040071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316642PMC
December 2018
6 Reads

Effect of pesticide exposure on the cholinesterase activity of the occupationally exposed tea garden workers of Northern part of West Bengal, India.

Biomarkers 2018 Dec 4:1-16. Epub 2018 Dec 4.

a Genetics and Molecular Biology Laboratory, Department of Zoology , University of North Bengal , P.O. NBU , Dist. Darjeeling, 734013 , West Bengal , India.

Context: Pesticide poisoning and related deaths is a global concern, but there is little information about its effect on the occupationally exposed tea garden workers of North Bengal.

Objective: This study investigates the level of AChE and BuChE in the blood of the tea garden workers, at risk of exposure to a mixture of pesticides.

Materials And Methods: The study sample consisted of pesticide exposed workers, non exposed (control), smokers and alcoholics. Read More

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https://www.tandfonline.com/doi/full/10.1080/1354750X.2018.1
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http://dx.doi.org/10.1080/1354750X.2018.1556342DOI Listing
December 2018
8 Reads

Insecticide resistance status, frequency of L1014F Kdr and G119S Ace-1 mutations, and expression of detoxification enzymes in Anopheles gambiae (s.l.) in two regions of northern Benin in preparation for indoor residual spraying.

Parasit Vectors 2018 Dec 4;11(1):618. Epub 2018 Dec 4.

Centre de Recherche entomologique de Cotonou (CREC), Cotonou, Benin.

Background: This study aims to provide baseline data on the resistance status to insecticides, the frequency of mechanisms involved and the impact of the association with the synergist piperonyl butoxide (PBO) on resistant Anopheles gambiae (s.l.) populations in two regions of northern Benin, prior to an indoor residual spraying campaign and introduction of next generation long-lasting insecticidal nets (LLINs) incorporating PBO. Read More

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http://dx.doi.org/10.1186/s13071-018-3180-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278060PMC
December 2018
3 Reads

Amorphous metal boride as a novel platform for acetylcholinesterase biosensor development and detection of organophosphate pesticides.

Nanotechnology 2019 Feb 30;30(5):055501. Epub 2018 Nov 30.

Key Laboratory of Applied Chemistry, Department of Applied Chemistry, Yanshan University, Qinhuangdao 066004, People's Republic of China.

The exploration of new materials for modifying electrodes is important to advance electrochemical biosensors. Herein, we demonstrated that amorphous bimetallic boride material (Co-2Ni-B) prepared by a simple and facile aqueous reaction is an efficient matrix to immobilize acetylcholinesterase (AChE) to construct a biosensor for the determination of organophosphate pesticides. The effects of different composition and crystallinity on its electrochemical performance are investigated, and the optimization studies of the biological transducer were also discussed. Read More

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http://dx.doi.org/10.1088/1361-6528/aaee3fDOI Listing
February 2019
1 Read
3.821 Impact Factor

A neuroprotective role of kaempferol against chlorpyrifos-induced oxidative stress and memory deficits in rats via GSK3β-Nrf2 signaling pathway.

Pestic Biochem Physiol 2018 Nov 13;152:29-37. Epub 2018 Aug 13.

Sharjah Institute for Medical Research and College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.

Chlorpyrifos (CPF) is an agricultural pesticide and a potential food contaminant, which causes neurotoxicity. Here, we aimed at exploring the link between the repeated exposure to CPF and memory dysfunction in rats and the possible protective effect of kaempferol, a flavonoid with appreciable antioxidant and anti-inflammatory activities. Rats were divided into: Control group (received drug vehicles for 14 days); CPF-treated group (received subcutaneous 18 mg/kg BW of CPF daily for 14 days and CPF + Kaempferol treated group (received the same CPF dose +21 mg/kg BW of Kaempferol intraperitoneally for 14 days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00483575183010
Publisher Site
http://dx.doi.org/10.1016/j.pestbp.2018.08.008DOI Listing
November 2018
2 Reads
2.014 Impact Factor

Gonadal impairment and parental transfer of tris (2-butoxyethyl) phosphate in zebrafish after long-term exposure to environmentally relevant concentrations.

Chemosphere 2019 Mar 22;218:449-457. Epub 2018 Nov 22.

College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:

Tris (2-butoxyethyl) phosphate (TBOEP) is a ubiquitous environmental contaminant due to its overuse. TBOEP has been found to cause reproductive toxicity and endocrine disruption during acute toxic experiment. In this study, we examined the effects of TBOEP on growth in initial generation (F0) zebrafish and transgenerational effects on growth of first generation (F1) larvae after parental long-term exposure (120 d) to environmentally relevant concentrations (0, 0. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.11.139DOI Listing
March 2019
2 Reads

Neuroprotection From Organophosphate-Induced Damage by Novel Phenoxyalkyl Pyridinium Oximes in Rat Brain.

Toxicol Sci 2018 Dec;166(2):420-427

Center for Environmental Health Sciences.

The nerve agents are extremely toxic organophosphates which lead to massive inhibition of acetylcholinesterase (AChE) in both the central and peripheral nervous systems. The currently approved pyridinium oxime reactivators of organophosphate-inhibited AChE (eg, 2-PAM in the United States) cannot penetrate the blood-brain barrier because of the permanent positive charge in the pyridinium ring. Therefore these current oximes cannot rescue inhibited AChE in the brain. Read More

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http://dx.doi.org/10.1093/toxsci/kfy212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260155PMC
December 2018
3 Reads

Effect of sub-toxic exposure to Malathion on glucose uptake and insulin signaling in L6 myoblast derived myotubes.

Drug Chem Toxicol 2018 Nov 29:1-8. Epub 2018 Nov 29.

a Department of Biochemistry , Maulana Azad Medical College , New Delhi , India.

Biochemical basis of Malathion exposure-induced diabetes mellitus is not known. Hence, effects of its sub-toxic exposure on redox sensitive kinases (RSKs), insulin signaling and insulin-induced glucose uptake were assessed in rat muscle cell line. In this in vitro study, rat myoblast (L6) cells were differentiated to myotubes and were exposed to sub-toxic concentrations (10 mg/l and 20 mg/l) of Malathion for 18 hours. Read More

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http://dx.doi.org/10.1080/01480545.2018.1531881DOI Listing
November 2018
1 Read

Migrant Farmworkers' Exposure to Pesticides in Sonora, Mexico.

Int J Environ Res Public Health 2018 11 26;15(12). Epub 2018 Nov 26.

Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave. PO 245210, Tucson, AZ 85724, USA.

Expanding agribusiness in Sonora, a state in Northern Mexico, has increased the demand for temporary migrant agricultural workers. Sonora is one of the top states in Mexico for pesticide utilization. We conducted an exploratory study to evaluate exposure to organophosphate (OP) and pyrethroid pesticides among migrant farmworkers. Read More

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http://dx.doi.org/10.3390/ijerph15122651DOI Listing
November 2018
1 Read

Biocatalytic membrane reactor development for organophosphates degradation.

J Hazard Mater 2019 Mar 17;365:789-795. Epub 2018 Nov 17.

Institute on Membrane Technology, National Research Council, ITM-CNR, via P. Bucci, 17/C, 87036 Rende, Cosenza, Italy.

Organophosphates (OPs) are highly toxic compounds used as pesticides and nerve agents. The devastating effects, reported in different studies, on the environment and human health indicate a serious scenario for both instantaneous and long terms effects. Bio-based strategies for OPs degradation seem the most promising solutions, particularly when extremophiles enzymes are used. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043894183109
Publisher Site
http://dx.doi.org/10.1016/j.jhazmat.2018.11.063DOI Listing
March 2019
9 Reads

Meta-Analysis of Insecticides in United States Surface Waters: Status and Future Implications.

Environ Sci Technol 2018 Dec 6;52(24):14452-14460. Epub 2018 Dec 6.

Institute for Environmental Sciences , University of Koblenz-Landau , Fortstrasse 7 , D-76829 Landau , Germany.

Agricultural insecticides occur in U.S. surface waters, yet our knowledge of their current and potential future large-scale risks for biodiversity is restricted. Read More

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http://pubs.acs.org/doi/10.1021/acs.est.8b04651
Publisher Site
http://dx.doi.org/10.1021/acs.est.8b04651DOI Listing
December 2018
11 Reads

Comparison of rates of direct and indirect migration of phosphorus flame retardants from flame-retardant-treated polyester curtains to indoor dust.

Ecotoxicol Environ Saf 2019 Mar;169:464-469

Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan.

In this study, the pathways for migration of phosphorus flame retardants (PFRs), tris(1,3-dichloroisopropyl) phosphate (TDCPP) and tricresyl phosphate (TCsP) which were detected from curtains often, from flame-retardant-treated polyester curtains to indoor dust were investigated. Two possible migration pathways were compared quantitatively: (1) an indirect pathway in which the PFRs in the curtains first evaporate from the curtains and are then adsorbed onto indoor dust and (2) a direct pathway in which the PFRs are directly transferred to dust placed on the curtains. The contribution of the indirect pathway was evaluated by means of emission cell tests, which showed that the area-specific emission rates from curtains treated with PFRs were 0. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.11.052DOI Listing
March 2019
1 Read

Ecotoxicity response of chlorpyrifos in Aedes aegypti larvae and Lactuca sativa seeds after UV/HO and UVC oxidation.

Ecotoxicol Environ Saf 2019 Mar 22;169:449-456. Epub 2018 Nov 22.

Federal University of Technology - Paraná, Brazil. Electronic address:

Chlorpyrifos (CP) is an organophosphate pesticide widely used in agriculture known to cause neurological and immunological effects in addition to interfering in the reproduction and development of organisms. In this study, CP degradation by UV/HO process and UVC radiation was investigated, and the ecotoxicity and phytotoxicity was evaluated using bioassays of Aedes aegypti larvae and Lactuca sativa seeds. CP degradation was monitored by HPLC-DAD, and kinetic parameters were calculated for all processes evaluated. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.11.003DOI Listing
March 2019
2 Reads

Characterization of farnesyl diphosphate farnesyl transferase 1 (FDFT1) expression in cancer.

Per Med 2019 01 23;16(1):51-65. Epub 2018 Nov 23.

Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.

Aim: To help characterize the FDFT1 gene and protein expression in cancer. Cholesterol represents an important structural component of lipid rafts. These specializations can be involved in pathways stimulating cell growth, survival and other processes active in cancer. Read More

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http://dx.doi.org/10.2217/pme-2016-0058DOI Listing
January 2019
11 Reads

Presence and human exposure assessment of organophosphate flame retardants (OPEs) in indoor dust and air in Beijing, China.

Ecotoxicol Environ Saf 2019 Mar 20;169:383-391. Epub 2018 Nov 20.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

In this study, levels of 14 organophosphate flame retardants (OPEs) were measured in 101 indoor dust samples collected from dormitories, residential homes, and offices in Beijing, China. In addition, paired air samples were also analyzed to evaluate any correlation between OPE levels in air and that in corresponding dust samples. The ΣOPEs levels substantially varied between individual samples. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.11.038DOI Listing
March 2019
10 Reads
2.762 Impact Factor

Quantifying the Impact of Excluding Insecticide Classes From Cotton Integrated Pest Management Programs in the U.S. Mid-South.

J Econ Entomol 2019 Feb;112(1):341-348

Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, Mississippi State, MS.

Current assessments from the U.S. Environmental Protection Agency suggest that some current insecticides may be lost or severely restricted in the near future. Read More

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http://dx.doi.org/10.1093/jee/toy339DOI Listing
February 2019
7 Reads

Monitoring Insecticide Resistance Profiles of Aedes aegypti (Diptera: Culicidae) in the Sunda Islands of Indonesia Based on Diagnostic Doses of Larvicides.

J Med Entomol 2018 Nov 20. Epub 2018 Nov 20.

Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.

This study was conducted to monitor the susceptibility status of Aedes aegypti (Linnaeus) larvae in the Sunda Islands of Indonesia against various organophosphates and organochlorines. Larval bioassay was performed in accordance with the World Health Organization standard protocol. Field-collected and reference strains of Ae. Read More

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http://dx.doi.org/10.1093/jme/tjy208DOI Listing
November 2018
21 Reads