31,357 results match your criteria Organophosphates


Risk assessment of resistance to diflubenzuron in Musca domestica: Realized heritability and cross-resistance to fourteen insecticides from different classes.

PLoS One 2022 13;17(5):e0268261. Epub 2022 May 13.

Department of Plant Protection, College of Food and Agriculture Sciences, Pesticides and Environmental Toxicology Laboratory, King Saud University, Riyadh, Saudi Arabia.

The Musca domestica L. is a well-known vector for a number of livestock and human diseases. One major challenge for maintaining effective control of this pest is its propensity to develop resistance to insecticides. Read More

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Effects of surface modification on toxicity of CeO nanoparticles to lettuce.

NanoImpact 2021 Oct 12;24:100364. Epub 2021 Nov 12.

Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China; CAS-HKU Joint Laboratory of Metallomics on Health & Environment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Phytotoxicity of nanoceria (nCeO) has been reported, but there are few studies on how to reduce its phytotoxicity. In the present study, we modified nCeO with two organophosphates ([email protected] and [email protected]) and compared their toxicity to lettuce with that of uncoated nCeO. The results showed that bare nCeO significantly inhibited the root growth of lettuce, leading to oxidative damages and root cell death. Read More

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October 2021

Cardiovascular and core temperature responses to acute organophosphate intoxication in rats.

FASEB J 2022 May;36 Suppl 1

UC-Davis, Davis, CA.

Introduction: Organophosphates (OP) are cholinesterase inhibitors that are used as pesticides in agriculture and as nerve agents in chemical warfare. Surprisingly, we have limited information on the time course of cardiovascular responses to acute OP intoxication at doses that cause cholinergic crisis in humans. OP-induced QT prolongation has been shown to lead to fatal ventricular arrhythmia and delayed death, however, not all cardiac failures are associated with QT prolongation. Read More

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Pesticide residues on children's hands, home indoor surfaces, and drinking water among conventional and organic farmers in Thailand.

Environ Monit Assess 2022 May 13;194(6):427. Epub 2022 May 13.

Department of Public Health, University of Massachusetts Lowell, Lowell, USA.

This study measured pesticide levels on children's hands, home indoor surfaces, and drinking water among Thai conventional and organic farm families in three provinces. Farm families in Nakhonsawan and Phitsanulok provinces were the conventional farmers and those in Yasothon province were the organic farmers. Samples were collected in the dry and wet seasons over 2 years (2017 and 2018). Read More

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Evaluation of a Gene-Environment Interaction of and Low-Level Nerve Agent Exposure with Gulf War Illness: A Prevalence Case-Control Study Drawn from the U.S. Military Health Survey's National Population Sample.

Environ Health Perspect 2022 May 11;130(5):57001. Epub 2022 May 11.

Division of Epidemiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Background: Consensus on the etiology of 1991 Gulf War illness (GWI) has been limited by lack of objective individual-level environmental exposure information and assumed recall bias.

Objectives: We investigated a prestated hypothesis of the association of GWI with a gene-environment (GxE) interaction of the () Q192R polymorphism and low-level nerve agent exposure.

Methods: A prevalence sample of 508 GWI cases and 508 nonpaired controls was drawn from the 8,020 participants in the U. Read More

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Systematic Review: Association of Pesticide Exposure and Child Wheeze and Asthma.

Curr Pediatr Rev 2022 May 10. Epub 2022 May 10.

Department of Pediatrics University of Maryland School of Medicine, Baltimore, MD 21201.

Background: The prevalence of wheeze and asthma has risen over recent decades for all age groups, especially children. These disorders can lead to decreased quality of life, missed school, urgent care and emergency department visits, hospitalizations, and increased health care costs. Environmental exposures, including pesticide exposure, are likely a contributing factor to this increased prevalence. Read More

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Insights in detection and analysis of organophosphates using organophosphorus acid anhydrolases (OPAA) enzyme-based biosensors.

Crit Rev Biotechnol 2022 May 3:1-19. Epub 2022 May 3.

Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, India.

The human population is dependent on agriculture for its food requirements and survival. Several insecticides and pesticides have found their use for improvements in agricultural yields. Organophosphates (OP) are one of the many compounds used as insecticides and pesticides. Read More

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Screening of Organophosphate Flame Retardants with Placentation-Disrupting Effects in Human Trophoblast Organoid Model and Characterization of Adverse Pregnancy Outcomes in Mice.

Environ Health Perspect 2022 05 3;130(5):57002. Epub 2022 May 3.

MOE Laboratory for Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing, China.

Background: Abnormal placental development may result in adverse pregnancy outcomes and metabolic diseases in adulthood; however, it remains unknown whether and how xenobiotics affect human placentation.

Objectives: This study aimed to screen and identify placentation-disrupting chemicals in commonly used organophosphate flame retardants (OPFRs) and, if identified, to investigate potential adverse effects on placentation in relation to adverse pregnancy outcomes and metabolic disorder in offspring in mice.

Methods: We devised a high-throughput immunofluorescence screening assay based on human trophoblast organoids and used it to screen OPFRs that inhibit the proliferation of organoids. Read More

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Ameliorative effect of selenium yeast supplementation on the physio-pathological impacts of chronic exposure to glyphosate and or malathion in Oreochromis niloticus.

BMC Vet Res 2022 05 1;18(1):159. Epub 2022 May 1.

Faculty of Veterinary Medicine, Department of Animal Hygiene, Zoonoses and Behaviour, Suez Canal University, Ismailia, 41522, Egypt.

Background: Pesticide exposure is thought to be a major contributor to living organism health deterioration, as evidenced by its impact on both cultured fish species and human health. Commercial fish diets are typically deficient in selenium (Se); hence, supplementation may be necessary to meet requirements during stress. Therefore, this study was conducted to investigate the protective role of selenium yeast (SY) supplementation for 60 days against the deleterious effects of glyphosate and or malathion chronic toxicity at sublethal concentrations in Oreochromis niloticus . Read More

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Impacts of dietary exposure to pesticides on faecal microbiome metabolism in adult twins.

Environ Health 2022 May 3;21(1):46. Epub 2022 May 3.

Gene Expression and Therapy Group, King's College London, Faculty of Life Sciences & Medicine, Department of Medical and Molecular Genetics, Guy's Hospital, London, SE1 9RT, UK.

Background: Dietary habits have a profound influence on the metabolic activity of gut microorganisms and their influence on health. Concerns have been raised as to whether the consumption of foodstuffs contaminated with pesticides can contribute to the development of chronic disease by affecting the gut microbiome. We performed the first pesticide biomonitoring survey of the British population, and subsequently used the results to perform the first pesticide association study on gut microbiome composition and function from the TwinsUK registry. Read More

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Interaction of borohydride stabilized silver nanoparticles with sulfur-containing organophosphates.

RSC Adv 2021 Sep 30;11(51):32286-32294. Epub 2021 Sep 30.

Department of Chemical Engineering, IIT Delhi Hauz Khas New Delhi 110016 India

Understanding the interactions between nanoparticles and organophosphates is the key to developing cost-effective colorimetric pesticide detection. We have studied the interaction between three different organophosphates containing the P[double bond, length as m-dash]S group and borohydride stabilized silver nanoparticles. Three different organophosphates, namely phorate, chlorpyrifos, and malathion, have been used. Read More

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September 2021

Acetylcholinesterase-capped mesoporous silica gated switches for selective detection of high-toxicity organophosphate compounds.

Anal Chim Acta 2022 May 1;1207:339708. Epub 2022 Apr 1.

State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China. Electronic address:

Organophosphate (OP) compounds are widely used in agriculture, industry, and even terrorism. It is important to distinguish high-toxicity OP compounds from low-toxicity OP compounds in dealing with chemical accidents. However, there are very few portable and simple detection methods. Read More

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Pilot monitoring scheme of water pollutants in Important Bird and Biodiversity Areas.

Ecotoxicol Environ Saf 2022 Jun 26;237:113562. Epub 2022 Apr 26.

Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain. Electronic address:

In this study we have established a monitoring scheme to determine the presence and distribution of widely used pharmaceuticals, pesticides, organophosphate esters (OPEs) and perfluoroalkyl substances (PFAS) in water bodies from Important Bird and Biodiversity Areas (IBAs) from Spain. The monitoring scheme included the georeferenced sampling of rocky mountain, Atlantic forest, riparian forest, Mediterranean forest, agricultural, inland aquatic and coastal aquatic IBAs, with the aim to evaluate the impact of widely used chemicals in those aquatic resources. Water samples were extracted using a generic solid-phase extraction protocol and analyzed by 3 analytical methods based on liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Read More

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Aggregation of FeO nanoparticle in the presence of organophosphate esters (OPEs).

Water Sci Technol 2022 Apr;85(8):2423-2431

Key Laboratory for Water Quality and Conservation of the Pearl River Delta , School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China E-mail:

Aggregation is a key process for determining the environmental behavior and impact of a nanoparticle (NP). Since organophosphate esters (OPEs), which are recognized as emerging contaminants, are distributed widely in the natural aquatic environment, they may contribute to interacting with NPs and ultimately influence their transport and fate. Here, we investigated two typical organophosphate esters OPEs on aggregation the FeO NP in aquatic environments. Read More

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Assessing the health hazard originated via pesticide chemicals in human through rabbit model in agricultural production system in Bangladesh.

BMC Pharmacol Toxicol 2022 04 28;23(1):28. Epub 2022 Apr 28.

Department of Physiology, Biochemistry and Pharmacology, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh.

Background: The use of chemical pesticides in developing countries like Bangladesh and their impacts on human health and food security is a global concern. Bangladesh is an agricultural dependent country for the growing population demand for food security and food safety. We conduct this study to assess public health threats of commonly utilised pesticides including malathion and nitrobenzene in female rabbit model. Read More

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Frequency of Acute Kidney Injury (AKI) among patients presenting with Organophosphate Poisoning at National Poison Control Centre, Karachi: A prospective cross-sectional survey.

Pak J Med Sci 2022 Mar-Apr;38(3Part-I):542-546

Dr. Rukhsana Abdul Sattar, FCPS. Department of Medicine, Ward - 5, Jinnah Postgarduate Medical Centre, Karachi, Pakistan.

Background And Objective: Organophosphates poisoning is among the most prevalent forms of intentional and unintentional poisoning in Pakistan. However, the actual burden of AKI secondary to organophosphate poisoning in Pakistani population is still not known. This study aimed to determine the actual burden of AKI among patients admitted at National Poison Control Centre, Karachi. Read More

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Amidoxime-functionalized bead cellulose for the decomposition of highly toxic organophosphates.

RSC Adv 2021 May 18;11(29):17976-17984. Epub 2021 May 18.

Faculty of the Environment, University of Jan Evangelista Purkyně Pasteurova 3632/16 400 96 Ústí nad Labem Czech Republic

Regenerated bead cellulose is a promising material with excellent mechanical and rheological properties, ideally suited for advanced environmental applications. By introducing the amidoxime functional group into the glucose unit at the C-6 position, highly effective reactive sorbent was prepared and used to destroy priority hazardous substances such as organophosphate pesticides or nerve-paralytic chemical warfare agents (CWAs). Quantum mechanical (QM) calculations were performed to study the interactions of organophosphates with amidoxime functional groups at the molecular level. Read More

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Water-soluble non-conjugated polymer dots with strong green fluorescence for sensitive detection of organophosphate pesticides.

Anal Chim Acta 2022 May 2;1206:339792. Epub 2022 Apr 2.

Huzhou Key Laboratory of Medical and Environmental Applications Technologies, School of Life Sciences, Huzhou University, Huzhou City, Zhejiang Province, 313000, PR China. Electronic address:

Water-soluble non-conjugated polymer dots (PDs) have been synthesized using hyperbranched polyethyleneimine (PEI) and dihydroxybenzaldehyde (DHB) for the first time via the Schiff base reaction at room temperature. The yielded non-conjugated PDs of PEI-DHB could display the well-defined spheric structure and good water solubility. In contrast to the common PDs otherwise showing blue emission, the PEI-DHB PDs could give out strong green fluorescence in aqueous media. Read More

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Rapid and non-invasive surface-enhanced Raman spectroscopy (SERS) detection of chlorpyrifos in fruits using disposable paper-based substrates charged with gold nanoparticle/halloysite nanotube composites.

Mikrochim Acta 2022 04 22;189(5):197. Epub 2022 Apr 22.

School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou, 221116, Jiangsu, China.

Chlorpyrifos is one of the most widely used organophosphate insecticides in agricultural production. Nevertheless, the residues of chlorpyrifos in agricultural by-product seriously threaten human health. Thus, the ultrasensitive detection of chlorpyrifos residues in agri-food products is of great demand. Read More

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Modulatory Effect of Papaya Extract against Chlorpyrifos-Induced Oxidative Stress, Immune Suppression, Endocrine Disruption, and DNA Damage in Female .

Int J Environ Res Public Health 2022 04 12;19(8). Epub 2022 Apr 12.

Department of Biological and Geological Sciences, Faculty of Education, Ain Shams University, Cairo 11757, Egypt.

Chlorpyrifos (CPF) is one of the widely used organophosphorus pesticides in agriculture activities and its presence in the aquatic environment has been broadly recorded. In the present study, we investigated the effect of CPF exposure on oxidative stress, innate immunity, sexual hormones, and DNA integrity of female African catfish, , in addition to the potential use of dietary supplementation of papaya, (CP), extract against CPF toxicity. Apparent healthy female catfish (300 ± 10 g) were divided into four groups with three replicates each. Read More

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, , and Are the Most Stably Expressed Genes during Osteogenic Differentiation.

Int J Mol Sci 2022 Apr 12;23(8). Epub 2022 Apr 12.

Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia.

RT-qPCR is the gold standard and the most commonly used method for measuring gene expression. Selection of appropriate reference gene(s) for normalization is a crucial part of RT-qPCR experimental design, which allows accurate quantification and reliability of the results. Because there is no universal reference gene and even commonly used housekeeping genes' expression can vary under certain conditions, careful selection of an appropriate internal control must be performed for each cell type or tissue and experimental design. Read More

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A Combinatorial and Tubulin-Based Polymorphism (TBP) Approach Helps in Discriminating Species.

Genes (Basel) 2022 04 1;13(4). Epub 2022 Apr 1.

Istituto Biologia e Biotecnologia Agraria, Via Edoardo Bassini 15, 20131 Milano, Italy.

The simple and straightforward recognition of species is not an easy task due to their complex genetic origins. To provide a recommendation, we have compared the performance of different PCR-based methods relying on the discrimination ability of the and () genes, as well as TBP (Tubulin-Based Polymorphism), a method based on the multiple amplification of genes of the β-tubulin family. Among these approaches, the PCR-RFLP (Restriction Fragment Length Polymorphism) assay based on a single-nucleotide polymorphism (SNP) present in the gene is the only one capable of fully discerning hexaploid spelt and common wheat species, while both and TBP fail with similar error frequencies. Read More

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Persistent neurobehavioral and neurochemical anomalies in middle-aged rats after maternal diazinon exposure.

Toxicology 2022 04 19;472:153189. Epub 2022 Apr 19.

Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA. Electronic address:

Diazinon is an organophosphate pesticide that has a history of wide use. Developmental exposures to organophosphates lead to neurobehavioral changes that emerge early in life and can persist into adulthood. However, preclinical studies have generally evaluated changes through young adulthood, whereas the persistence or progression of deficits into middle age remain poorly understood. Read More

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PNPLA6/NTE, an Evolutionary Conserved Phospholipase Linked to a Group of Complex Human Diseases.

Metabolites 2022 Mar 24;12(4). Epub 2022 Mar 24.

Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, OR 97239, USA.

Patatin-like phospholipase domain-containing protein 6 (PNPLA6), originally called Neuropathy Target Esterase (NTE), belongs to a family of hydrolases with at least eight members in mammals. PNPLA6/NTE was first identified as a key factor in Organophosphate-induced delayed neuropathy, a degenerative syndrome that occurs after exposure to organophosphates found in pesticides and nerve agents. More recently, mutations in PNPLA6/NTE have been linked with a number of inherited diseases with diverse clinical symptoms that include spastic paraplegia, ataxia, and chorioretinal dystrophy. Read More

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Study of Organophosphorus Compound Poisoning in a Tertiary Care Hospital and the Role of Peradeniya Organophosphorus Poisoning Scale as a Prognostic Marker of the Outcome.

J Assoc Physicians India 2022 Apr;70(4):11-12

TMH, Jamshedpur.

Organophosphate compounds (OPC) cause most selfpoisoning deaths in India due to their easy availability and lack of stringent laws.

Aim: To evaluate the clinical profile and outcome of the patients presenting with OPC poisoning and to study the prognostic value of Peradeniya Organophosphorus Poisoning Scale (POPS) in predicting the clinical outcomes.

Material: This was a prospective study involving 100 patients of OPC poisoning admitted to Tata Main Hospital from June 2018 to May 2020 based on the inclusion criteria. Read More

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RDW a Predictor in OP Poisoning.

Authors:
Adithya A Adarsh Ls

J Assoc Physicians India 2022 Apr;70(4):11-12

JSS Medical College, JSSAHER, Mysuru.

Organophosphorus compound poisoning is a widely common problem in a developing country like Indian and it is a major clinical and public health concern. There have been efforts to find novel tools / markers to assess the prognosis and the use of RDW has been proposed in the OPCs poisoning, where in RDW can be used as a predictor of outcomes in OPCs poisoning. There have been several attempts to find out whether RDW can infact be used as a predictor of outcomes, but almost all of these studies so far have been done on a retrospective study. Read More

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Enzyme Nanoreactor for Detoxification of Organophosphates.

ACS Appl Mater Interfaces 2022 May 19;14(17):19241-19252. Epub 2022 Apr 19.

Biochemical Neuropharmacology Laboratory, Kazan Federal University, Kremlevskaya Str., 18, Kazan 420111, Russian Federation.

A nanoreactor containing an evolved mutant of phosphotriesterase (L72C/Y97F/Y99F/W263V/I280T) as a catalytic bioscavenger was made for detoxification of organophosphates. This nanoreactor intended for treatment of organophosphate poisoning was studied against paraoxon (POX). Nanoreactors were low polydispersity polymersomes containing a high concentration of enzyme (20 μM). Read More

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Mechanisms and treatment strategies of organophosphate pesticide induced neurotoxicity in humans: A critical appraisal.

Toxicology 2022 04 16;472:153181. Epub 2022 Apr 16.

Toxicology and Pharmacology Laboratory, Department of Zoology, Baba Ghulam Shah Badshah University, Rajouri 185234, Jammu and Kashmir, India. Electronic address:

Organophosphates (OPs) are commonly used pesticides worldwide. Humans are exposed to OPs via different routes viz., the respiratory tract, gastrointestinal tract, and dermal integuments. Read More

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