332,766 results match your criteria Organic Letters [Journal]


Spatial and temporal heterogeneity in the structure and function of sediment bacterial communities of a tropical mangrove forest.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Wetland Research and Training Centre, Chilika Development Authority, Balugaon, Odisha, 752030, India.

Bacterial communities of mangrove sediments are well appreciated for their role in nutrient cycling. However, spatiotemporal variability in these communities over large geographical scale remains understudied. We investigated sediment bacterial communities and their metabolic potential in an intertidal mangrove forest of India, Bhitarkanika, using high-throughput sequencing of 16S rRNA genes and community-level physiological profiling. Read More

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December 2018

Anaerobic treatment of residuals from tanks transporting food and fodder.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Faculty of Agricultural and Environmental Sciences, University of Rostock, Justus-von-Liebig-Weg 6, 18059, Rostock, Germany.

The anaerobic digestion of wastewater from the cleaning of tank cars transporting food and fodder was investigated in both bench and pilot scales with a single-stage, mesophilic (39 °C), completely mixed process. The promising results lead to the planning and building of a 1200-m full-scale biogas plant at TS-Clean cleaning station in Fahrbinde, Germany. Due to softened water used in the cleaning of the car tanks, the alkalinity in the digester decreased as predicted by the physicochemical model developed for this treatment process. Read More

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December 2018
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Emission of Unintentionally Produced Persistent Organic Pollutants from Some Industrial Processes in Northern Vietnam.

Bull Environ Contam Toxicol 2018 Dec 13. Epub 2018 Dec 13.

Vietnam Academy of Science and Technology, Institute of Environmental Technology and Graduate University of Science and Technology, 18 Hoang Quoc Viet, Hanoi, Vietnam.

Concentrations of PCDD/Fs, dioxin-like PCBs (dl-PCBs), PeCB and HCB were determined in flue gas, fly ash and bottom ash samples collected from brick production, steel production, and zinc production plants, an industrial waste incinerator and a medical waste incinerator in northern Vietnam to understand the contamination levels, accumulation patterns and extent of emission. Total TEQs concentrations of PCDD/Fs and dl-PCBs in flue gas and ash samples from these industrial plants ranged from 0.304 to 50. Read More

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December 2018

Multicomponent new particle formation from sulfuric acid, ammonia, and biogenic vapors.

Sci Adv 2018 Dec 12;4(12):eaau5363. Epub 2018 Dec 12.

Institute for Atmospheric and Earth System Research/Physics, Faculty of Science, University of Helsinki, P.O. Box 64, FI-00014 Helsinki, Finland.

A major fraction of atmospheric aerosol particles, which affect both air quality and climate, form from gaseous precursors in the atmosphere. Highly oxygenated organic molecules (HOMs), formed by oxidation of biogenic volatile organic compounds, are known to participate in particle formation and growth. However, it is not well understood how they interact with atmospheric pollutants, such as nitrogen oxides (NO ) and sulfur oxides (SO ) from fossil fuel combustion, as well as ammonia (NH) from livestock and fertilizers. Read More

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December 2018

Perfluorophenyl Derivatives as Unsymmetrical Linkers for Solid Phase Conjugation.

Front Chem 2018 28;6:589. Epub 2018 Nov 28.

School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.

Linkers play major roles in conjugation chemistry toward the advancement of drug discovery. Two different series of fluorinated linkers were introduced to the backbone of a model peptide using solid phase peptide synthesis. These fluorinated linkers have the potential to conjugate two asymmetrical groups. Read More

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November 2018

Pyrene-Imidazole Based Aggregation Modifier Leads to Enhancement in Efficiency and Environmental Stability for Ternary Organic Solar Cells.

Front Chem 2018 28;6:578. Epub 2018 Nov 28.

School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China.

A novel pyrene-imidazole derivative (PyPI), which can form effcient π-π stacking in solid film, has been utilized in organic solar cells (OSCs). The stacking of small a molecule PyPI can facilitate a charge transfer and suppress fullerene aggregation. As a result, PTB7-Th: PyPI: PCBM based ternary OSC exhibits a high power conversion efficiency (PCE) of 10. Read More

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November 2018
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The nanoscaled metal-organic framework ICR-2 as a carrier of porphyrins for photodynamic therapy.

Beilstein J Nanotechnol 2018 30;9:2960-2967. Epub 2018 Nov 30.

Department of Materials Chemistry, Institute of Inorganic Chemistry of the Czech Academy of Sciences, Husinec-Řež 1001, 250 68 Řež, Czech Republic.

Nanosized porphyrin-containing metal-organic frameworks (MOFs) attract considerable attention as solid-state photosensitizers for biological applications. In this study, we have for the first time synthesised and characterised phosphinate-based MOF nanoparticles, nanoICR-2 (Inorganic Chemistry Rez). We demonstrate that nanoICR-2 can be decorated with anionic 5,10,15,20-tetrakis(4-R-phosphinatophenyl)porphyrins (R = methyl, isopropyl, phenyl) by utilizing unsaturated metal sites on the nanoparticle surface. Read More

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November 2018

Layered calcium phenylphosphonate: a hybrid material for a new generation of nanofillers.

Beilstein J Nanotechnol 2018 20;9:2906-2915. Epub 2018 Nov 20.

SYNPO, akciová společnost, S. K. Neumanna 1316, 532 07 Pardubice, Czech Republic.

The use of nanosheets of layered calcium phenylphosphonate as a filler in a polymeric matrix was investigated. Layered calcium phenylphosphonate (CaPhP), with chemical formula CaCHPO∙2HO, is a hybrid organic-inorganic material that exhibits a hydrophobic character due to the presence of phenyl groups on the surface of the layers. In this paper, various CaPhP synthesis methods were studied with the aim of obtaining a product most suitable for its subsequent exfoliation. Read More

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November 2018
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Fragranced consumer products: effects on autistic adults in the United States, Australia, and United Kingdom.

Authors:
Anne Steinemann

Air Qual Atmos Health 2018 25;11(10):1137-1142. Epub 2018 Sep 25.

1Department of Infrastructure Engineering, Melbourne School of Engineering, The University of Melbourne, Parkville, Victoria 3010 Australia.

Fragranced consumer products, such as cleaning supplies, air fresheners, and personal care products, can have adverse effects on both air quality and health. This study investigates the effects of fragranced products on autistic individuals ages 18-65 in the United States, Australia, and United Kingdom. Nationally representative population surveys ( = 1137; 1098; 1100) found that, across the three countries, 4. Read More

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September 2018
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1,8-Bis(dimethylamino)naphthyl-2-ketimines: Inside vs outside protonation.

Beilstein J Org Chem 2018 28;14:2940-2948. Epub 2018 Nov 28.

Institute of Chemistry, St. Petersburg State University, Universitetskii pr. 26, 198504 St. Petersburg, Russian Federation.

The structure and protonation behaviour of four -arylketimines of 1,8-bis(dimethylamonio)naphthalene with a different number of methoxy groups in an aromatic substituent were investigated in solution by NMR (acetone, DMSO, MeCN), in solid state by X-ray analysis and in the gas phase by DFT calculations. Both mono- and diprotonated species were considered. It has been shown that -isomers of neutral imines can be stabilised by an intramolecular C=N-H···OMe hydrogen bond with a neighbouring methoxy group. Read More

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November 2018

Copper(I)-catalyzed tandem reaction: synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and alkynes.

Beilstein J Org Chem 2018 23;14:2916-2922. Epub 2018 Nov 23.

Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Center for Excellence in Molecular Synthesis, Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou, Fujian 350002, P. R. China.

A copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction for the synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and terminal alkynes is reported. The alkyl carboxylic acids is for the first time being used as the alkyl azide precursors in the form of alkyl diacyl peroxides. This method avoids the necessity to handle organic azides, as they are generated in situ, making this protocol operationally simple. Read More

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November 2018

Synthesis of indole-cycloalkyl[]pyridine hybrids via a four-component six-step tandem process.

Beilstein J Org Chem 2018 22;14:2907-2915. Epub 2018 Nov 22.

Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India.

The one-pot four-component reaction of 3-(1-indol-3-yl)-3-oxopropanenitriles, aromatic aldehydes, cycloalkanones and ammonium acetate occurred via a six-step tandem Knoevenagel condensation-nucleophilic addition to carbonyl-Michael addition-N-cyclization-elimination-air oxidation sequence to afford structurally intriguing indole-cycloalkyl[]pyridine-3-carbonitrile hybrid heterocycles in excellent yields. Read More

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November 2018

Generation of 1,2-oxathiolium ions from (arysulfonyl)- and (arylsulfinyl)allenes in Brønsted acids. NMR and DFT study of these cations and their reactions.

Beilstein J Org Chem 2018 22;14:2897-2906. Epub 2018 Nov 22.

Department of Organic Chemistry, Institute of Chemistry, Saint Petersburg State University, Universitetskaya nab., 7/9, Saint Petersburg, 199034, Russia.

In strong Brønsted acids (CFSOH, FSOH, DSO), (arysulfonyl)allenes (ArSO-CR=C=CRR) and (arylsulfinyl)allenes (ArSO-CR=C=CRR) undergo cyclization into the corresponding stable 1,2-oxathiolium ions, which were studied by means of NMR and DFT calculations. Quenching of solutions of these cations with low nucleophilic media, aqueous HCl, leads to their deprotonation with a stereoselective formation of (arysulfonyl)butadienes (for instance, ArSO-CR=C-C(Me)=CH, for R = R = Me, yields of 87-98%). Reactions of (arysulfonyl)allenes in the system TfOH (0. Read More

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November 2018

Effect of Cadmium Accumulation on the Performance of Plants and of Herbivores That Cope Differently With Organic Defenses.

Front Plant Sci 2018 28;9:1723. Epub 2018 Nov 28.

Centro de Ecologia, Evolução e Alterações Ambientais, Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal.

Some plants are able to accumulate in their shoots metals at levels that are toxic to most other organisms. This ability may serve as a defence against herbivores. Therefore, both metal-based and organic defences may affect herbivores. Read More

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November 2018

Estimating PM speciation concentrations using prototype 4.4 km-resolution MISR aerosol properties over Southern California.

Atmos Environ (1994) 2018 May 10;181:70-81. Epub 2018 Mar 10.

Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States.

Research efforts to better characterize the differential toxicity of PM (particles with aerodynamic diameters less than or equal to 2.5 μm) speciation are often hindered by the sparse or non-existent coverage of ground monitors. The Multi-angle Imaging SpectroRadiometer (MISR) aboard NASA's Terra satellite is one of few satellite aerosol sensors providing information of aerosol shape, size and extinction globally for a long and continuous period that can be used to estimate PM speciation concentrations since year 2000. Read More

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Restoration of Vegetation in Relation to Soil Properties of Spoil Heap Heavily Contaminated with Heavy Metals.

Water Air Soil Pollut 2018 24;229(12):392. Epub 2018 Nov 24.

1Department of Forest Ecology and Reclamation, University of Agriculture in Krakow, al. 29 Listopada 46, 31-425 Krakow, Poland.

The main objectives of our study were to evaluate soil contamination on a zinc-lead spoil heap in the Upper Silesian Industrial Region in southern Poland using pollution indices, and to investigate the relation between soil properties and the natural succession of vegetation. Organic carbon and nitrogen, pH, soil texture, base cations, and heavy metal content were analyzed in soil samples at depths of 0-15 cm below the organic horizon over a regular grid of 14 sampling plots. The contents of Zn, Pb, and Cd exceeded by several times the acceptable thresholds. Read More

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November 2018

Determinants of environmental styrene exposure in Gulf coast residents.

J Expo Sci Environ Epidemiol 2018 Dec 13. Epub 2018 Dec 13.

Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.

Background: In a previous study of exposure to oil-related chemicals in Gulf coast residents, we measured blood levels of volatile organic compounds. Levels of styrene were substantially elevated compared to a nationally representative sample. We sought to identify factors contributing to these levels, given the opportunities for styrene exposure in this community. Read More

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December 2018

Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy.

Nat Commun 2018 Dec 13;9(1):5306. Epub 2018 Dec 13.

Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.

Nanocarrier-based drug delivery is a promising therapeutic approach that offers unique possibilities for the treatment of various diseases. However, inside the blood stream, nanocarriers' properties may change significantly due to interactions with proteins, aggregation, decomposition or premature loss of cargo. Thus, a method for precise, in situ characterization of drug nanocarriers in blood is needed. Read More

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December 2018

Immobilization of cadmium and lead in contaminated paddy field using inorganic and organic additives.

Sci Rep 2018 Dec 13;8(1):17839. Epub 2018 Dec 13.

Ministry of Education (MOE) Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resources Science, Zhejiang University, Hangzhou, 310058, People's Republic of China.

Heavy metal contamination of agricultural soils has posed a risk to environment and human health. The present study was conducted to assess the effectiveness of soil amendments for reducing cadmium (Cd) and lead (Pb) uptake by rice (Oryza sativa L) in a contaminated field. The soil amendments used include lime, DaSan Yuan (DASY), DiKang No. Read More

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December 2018
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Assessing the nature of the charge-transfer electronic states in organic solar cells.

Nat Commun 2018 Dec 13;9(1):5295. Epub 2018 Dec 13.

School of Chemistry and Biochemistry and Center for Organic Photonics and Electronics, Georgia Institute of Technology, Atlanta, Georgia, 30332-0400, USA.

The charge-transfer electronic states appearing at the donor-acceptor interfaces in organic solar cells mediate exciton dissociation, charge generation, and charge recombination. To date, the characterization of their nature has been carried out on the basis of models that only involve the charge-transfer state and the ground state. Here, we demonstrate that it is essential to go beyond such a two-state model and to consider explicitly as well the electronic and vibrational couplings with the local absorbing state on the donor and/or acceptor. Read More

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December 2018

Evolution of a highly active and enantiospecific metalloenzyme from short peptides.

Science 2018 Dec;362(6420):1285-1288

Laboratory of Organic Chemistry, ETH Zürich, 8093 Zürich, Switzerland.

Primordial sequence signatures in modern proteins imply ancestral origins tracing back to simple peptides. Although short peptides seldom adopt unique folds, metal ions might have templated their assembly into higher-order structures in early evolution and imparted useful chemical reactivity. Recapitulating such a biogenetic scenario, we have combined design and laboratory evolution to transform a zinc-binding peptide into a globular enzyme capable of accelerating ester cleavage with exacting enantiospecificity and high catalytic efficiency (/ ~ 10 M s). Read More

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December 2018

Website Analytics of a Google Ads Campaign for a Men's Mental Health Website: Comparative Analysis.

JMIR Ment Health 2018 Dec 13;5(4):e12428. Epub 2018 Dec 13.

College of Pharmacy, Faculty of Health, Dalhousie University, Halifax, NS, Canada.

Background: Men with mental health and addictions problems seek information and help from health service providers and community support less often than women with such problems. Online health resources offer men rapid access to self-care recommendations and resources and anonymity; however, only a few websites are specifically developed for men. Headstrong - Taking Things Head-On was a community pharmacy and online health promotion initiative for men living with mental health and addictions problems. Read More

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December 2018
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Associations of greenness with diabetes mellitus and glucose-homeostasis markers: The 33 Communities Chinese Health Study.

Int J Hyg Environ Health 2018 Dec 10. Epub 2018 Dec 10.

Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Guangdong Provincial Engineering Technology Research Center of Environmental and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address:

Background: Residing in greener places may be protective against diabetes mellitus (DM) but evidence is scarce and comes mainly from developed countries.

Objectives: To investigate associations of residential greenness with DM prevalence and glucose-homeostasis markers in Chinese adults and whether these associations were mediated by air pollution, physical activity, and body mass index.

Methods: In 2009, a total of 15,477 adults from the cross-sectional 33 Communities Chinese Health Study provided blood samples and completed a questionnaire. Read More

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December 2018
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Fluorine-phenanthroimidazole Porous Organic Polymer: Efficient Microwave Synthesis and Photocatalytic Activity.

ACS Appl Mater Interfaces 2018 Dec 14. Epub 2018 Dec 14.

A porous polymer containing a fluorophenylphenanthroimidazole core was easily prepared via one-pot Suzuki-Miyaura cross coupling reactions under microwave heating. These new metal-free polymers have demonstrated heterogeneous photocatalytic activity toward aza-Henry reaction with reasonable recyclability. Their preparation require a minimal workup to build porous networks with control over the apparent surface area and pore volume from suitable molecular building blocks containing the 2-(1H-phenanthro[9,10-d]imidazol-2-yl)-3,5-difluorophenol (PhIm-2F), as rigid and multitopic node which afforded a conjugated porous polymer (CPP-PhIm-2F). Read More

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December 2018

The Antitumor Activity of a Lead Thioxanthone is Associated with Alterations in Cholesterol Localization.

Molecules 2018 Dec 12;23(12). Epub 2018 Dec 12.

i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.

The search for novel anticancer small molecules and strategies remains a challenge. Our previous studies have identified TXA1 (1-{[2-(diethylamino)ethyl]amino}-4-propoxy-9H- thioxanthen-9-one) as a hit compound, with in vitro antitumor potential by modulating autophagy and apoptosis in human tumor cell lines. In the present study, the mechanism of action and antitumor potential of the soluble salt of this molecule (TXA1. Read More

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December 2018

Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine.

Pharmaceutics 2018 Dec 12;10(4). Epub 2018 Dec 12.

Dongguan Key Laboratory of Drug Design and Formulation Technology, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan 523808, China.

Metal-organic frameworks (MOFs) show promising application in biomedicine and pharmaceutics owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs are prepared from non-renewable or toxic materials, which limit their real-world applications. Cyclodextrins (CDs) are a typical natural and biodegradable cyclic oligosaccharide and are primarily used to enhance the aqueous solubility, safety, and bioavailability of drugs by virtue of its low toxicity and highly flexible structure, offering a peculiar ability to form CD/drug inclusions. Read More

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December 2018

Design of a Semi-Continuous Selective Layer Based on Deposition of UiO-66 Nanoparticles for Nanofiltration.

Membranes (Basel) 2018 Dec 12;8(4). Epub 2018 Dec 12.

Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan.

Deposition of UiO-66 metal⁻organic framework nanoparticles onto a porous polymer support is a promising approach to designing highly-permeable, size-selective, flexible, and stable membranes for water filtration. In this article, a series of UiO-66 nanoparticles having different particle sizes were synthesized and employed to prepare UiO-66-deposited composite membranes. It was found that the size of the UiO-66 nanoparticles had great influences on the performance of the composite membranes for the filtration of a methylene blue aqueous solution. Read More

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December 2018

The Marine Dinoflagellate Activates a Mitophagic Pathway in Human Lung Cancer Cells.

Mar Drugs 2018 Dec 12;16(12). Epub 2018 Dec 12.

Stazione Zoologica Anton Dohrn, Istituo Nazionale di Biologia, Ecologia e Biotecnologie Marine, Villa Comunale, 80121 Naples, Italy.

Marine dinoflagellates are a valuable source of bioactive molecules. Many species produce cytotoxic compounds and some of these compounds have also been investigated for their anticancer potential. Here, we report the first investigation of the toxic dinoflagellate as source of water-soluble compounds with antiproliferative activity against human lung cancer cells. Read More

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December 2018

Combination of Dry Milling and Separation Processes with Anaerobic Digestion of Olive Mill Solid Waste: Methane Production and Energy Efficiency.

Molecules 2018 Dec 12;23(12). Epub 2018 Dec 12.

IATE, CIRAD, Montpellier SupAgro, INRA, Université de Montpellier, 34060 Montpellier, France.

This experimental work aims at investigating the effects of milling; sieving; and electrostatic separation on the biochemical methane potential of two olive pomaces from traditional olive oil extraction (M) and from a three-phase system (T). Sieving proved to be efficient for increasing the soluble chemical oxygen demand in the smallest fractions of the sieve of both M (62%) and T (78%) samples. The positive fraction following electrostatic separation also enhanced chemical oxygen demand (COD) solubilisation by 94%, in comparison to sample T milled at 4 mm. Read More

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December 2018

Exploring the Roles of Aquaporins in Plant⁻Microbe Interactions.

Cells 2018 Dec 11;7(12). Epub 2018 Dec 11.

Jiangsu Provincial Key Lab of Solid Organic Waste Utilization, Jiangsu Collaborative Innovation Center of Solid Organic Wastes, Educational Ministry Engineering Center of Resource-Saving Fertilizers, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China.

Aquaporins (AQPs) are membrane channel proteins regulating the flux of water and other various small solutes across membranes. Significant progress has been made in understanding the roles of AQPs in plants' physiological processes, and now their activities in various plant⁻microbe interactions are receiving more attention. This review summarizes the various roles of different AQPs during interactions with microbes which have positive and negative consequences on the host plants. Read More

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December 2018
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Optimization and Validation of a Chromatographic Method for the Quantification of Isoniazid in Urine of Tuberculosis Patients According to the European Medicines Agency Guideline.

Antibiotics (Basel) 2018 Dec 11;7(4). Epub 2018 Dec 11.

Química Bioanalítica, Departament de Química Física i Analítica, Escola Superior de Tecnologia i Ciències Experimentals, Universitat Jaume I, 12071 Castelló, Spain.

Isoniazid is a drug that is widely used against tuberculosis. However, it shows high interpatient variability in metabolism kinetics and clinical effect, which complicates the prescription of the medication and jeopardizes the success of the therapy. Therefore, in a specific patient, the pharmacokinetics of the drug must be elucidated to decide the proper dosage and intake frequency to make the drug suitable for therapeutic drug monitoring. Read More

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December 2018

Evolution of Volatile Compounds and Spoilage Bacteria in Smoked Bacon during Refrigeration Using an E-Nose and GC-MS Combined with Partial Least Squares Regression.

Molecules 2018 Dec 11;23(12). Epub 2018 Dec 11.

School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

The changes in the concentration of volatile organic compounds (VOCs) and biogenic amines (BAs) in smoked bacon during 45-day refrigerated storage is investigated using solid-phase micro-extraction coupled with gas chromatography-mass spectrometry and high-performance liquid chromatography. In total, 56 VOCs and 6 BAs were identified and quantified. The possible pathways leading to their formation are analyzed and considered as the potential signs of microbial activity, especially by specific spoilage microorganisms (SSOs). Read More

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December 2018
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Impact of Promoter Polymorphisms on the Transcriptional Regulation of the Organic Cation Transporter OCT1 (SLC22A1).

J Pers Med 2018 Dec 11;8(4). Epub 2018 Dec 11.

Institute of Pharmacology, Center of Drug Absorption and Transport (C_DAT), University Medicine Greifswald, 17487 Greifswald, Germany.

The organic cation transporter 1 (OCT1, SLC22A1) is strongly expressed in the human liver and facilitates the hepatic uptake of drugs such as morphine, metformin, tropisetron, sumatriptan and fenoterol and of endogenous substances such as thiamine. OCT1 expression is inter-individually highly variable. Here, we analyzed SNPs in the promoter concerning their potential contribution to the variability in OCT1 expression. Read More

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December 2018

Overview of DNA Self-Assembling: Progresses in Biomedical Applications.

Pharmaceutics 2018 Dec 11;10(4). Epub 2018 Dec 11.

Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Jordi Girona 18-26, E-08034 Barcelona, Spain.

Molecular self-assembling is ubiquitous in nature providing structural and functional machinery for the cells. In recent decades, material science has been inspired by the nature's assembly principles to create artificially higher-order structures customized with therapeutic and targeting molecules, organic and inorganic fluorescent probes that have opened new perspectives for biomedical applications. Among these novel man-made materials, DNA nanostructures hold great promise for the modular assembly of biocompatible molecules at the nanoscale of multiple shapes and sizes, designed via molecular programming languages. Read More

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December 2018

Combining a QSAR Approach and Structural Analysis to Derive an SAR Map of Lyn Kinase Inhibition.

Molecules 2018 Dec 11;23(12). Epub 2018 Dec 11.

AgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660⁻Hay Moulay Rachid, 43150 Ben-Guerir, Morocco.

Lyn kinase, a member of the Src family of protein tyrosine kinases, is mainly expressed by various hematopoietic cells, neural and adipose tissues. Abnormal Lyn kinase regulation causes various diseases such as cancers. Thus, Lyn represents, a potential target to develop new antitumor drugs. Read More

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December 2018

Modelization of Nutrient Removal Processes at a Large WWTP Using a Modified ASM2d Model.

Int J Environ Res Public Health 2018 Dec 11;15(12). Epub 2018 Dec 11.

ITQUIMA, Chemical Engineering Department, University Castilla-La Mancha, 13071 Ciudad Real, Spain.

The biodegradation of particulate substrates starts by a hydrolytic stage. Hydrolysis is a slow reaction and usually becomes the rate limiting step of the organic substrates biodegradation. The objective of this work was to evaluate a novel hydrolysis concept based on a modification of the activated sludge model (ASM2d) and to compare it with the original ASM2d model. Read More

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December 2018

Solvents to Fragments to Drugs: MD Applications in Drug Design.

Molecules 2018 Dec 11;23(12). Epub 2018 Dec 11.

Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluís Companys 23, 08010 Barcelona, Spain.

Simulations of molecular dynamics (MD) are playing an increasingly important role in structure-based drug discovery (SBDD). Here we review the use of MD for proteins in aqueous solvation, organic/aqueous mixed solvents (MDmix) and with small ligands, to the classic SBDD problems: Binding mode and binding free energy predictions. The simulation of proteins in their condensed state reveals solvent structures and preferential interaction sites (hot spots) on the protein surface. Read More

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December 2018

Simultaneous Determination of 18 Polycyclic Aromatic Hydrocarbons in Daily Foods (Hanoi Metropolitan Area) by Gas Chromatography⁻Tandem Mass Spectrometry.

Foods 2018 Dec 8;7(12). Epub 2018 Dec 8.

Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi 100000, Vietnam.

Polycyclic aromatic hydrocarbons (PAHs)-a large group of organic compounds-are extremely hazardous to human health. In this study, the 198 samples from six groups of daily food products in the Hanoi metropolitan area were collected and prepared by the QuEChERS sample treatment technique. The detection and identification of PAHs were obtained by gas chromatography⁻tandem mass spectrometry (GC⁻MS/MS) determination. Read More

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December 2018
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The Effect of Organic Acid, Trisodium Phosphate and Essential Oil Component Immersion Treatments on the Microbiology of Cod () during Chilled Storage.

Foods 2018 Dec 8;7(12). Epub 2018 Dec 8.

Teagasc Food Research Centre, Ashtown, 15 Dublin, Ireland.

Spoilage is a major issue for the seafood sector with the sale and exportation of fish limited by their short shelf-life. The immediate and storage effects of immersion (30 s at 20 °C) with 5% (/) citric acid (CA), 5% (/) lactic acid (LA), 5% (/) capric acid (CP) and 12% trisodium phosphate (TSP) (experiment 1) and essential oil components (EOC) (1% (/) citral (CIT), 1% (/) carvacrol (CAR), 1% (/) thymol (THY) and 1% (/) eugenol (EUG)) (experiment 2) on the concentrations of indicator (total viable counts (TVC) (mesophilic and psychrophilic) and total counts (TEC)), and spoilage organisms ( spp., lactic acid bacteria (LAB), , spp. Read More

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December 2018

Supramolecular Modification of ABC Triblock Terpolymers in Confinement Assembly.

Nanomaterials (Basel) 2018 Dec 10;8(12). Epub 2018 Dec 10.

Physical Chemistry, University of Duisburg-Essen, 47057 Duisburg, Germany.

The self-assembly of AB diblock copolymers in three-dimensional (3D) soft confinement of nanoemulsions has recently become an attractive bottom up route to prepare colloids with controlled inner morphologies. In that regard, ABC triblock terpolymers show a more complex morphological behavior and could thus give access to extensive libraries of multicompartment microparticles. However, knowledge about their self-assembly in confinement is very limited thus far. Read More

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December 2018

Response Surface Methodology for the Optimization of Ultrasound-Assisted Extraction of Tetrodotoxin from the Liver of .

Toxins (Basel) 2018 Dec 10;10(12). Epub 2018 Dec 10.

Laboratory of Aquatic Product Processing and Quality Safety, Marine Fisheries Research Institute of Zhejiang, Zhoushan 316100, China.

Tetrodotoxin (TTX) is a marine biotoxin that has high scientific value. However, the lack of efficient TTX extraction and preparation methods has led to a scarcity of TTX samples for clinical application. In this study, TTX from the liver of was ultrasound-assisted extracted with acidified organic solvents. Read More

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December 2018

Determinants of Termite Assemblages' Characteristics within Natural Habitats of a Sudano-Guinean Savanna (Comoe National Park, Côte d'Ivoire).

Insects 2018 Dec 10;9(4). Epub 2018 Dec 10.

Station de Recherche en Ecologie du Parc National de la Comoé, 27 BP 847 Abidjan 27, Ivory Coast.

Termites are one of the major components of tropical ecosystems. However, the ecological and biological variables determining the structure of their communities within natural habitats are less documented in general and especially in the Comoe National Park, a Sudano-Guinean savanna zone located in the north-eastern part of Côte d'Ivoire (West Africa). Using a standardized method of belt transects, the structure of termite's communities was estimated within habitats differing in the structure of their vegetation, soil characteristics, and the disturbance level caused by annual occurrences of bushfires. Read More

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December 2018

Mechanoresponsive Material of AIE-Active 1,4-Dihydropyrrolo[3,2-b]pyrrole Luminophores Bearing Tetraphenylethylene Group with Rewritable Data Storage.

Molecules 2018 Dec 10;23(12). Epub 2018 Dec 10.

Anhui Province Key Laboratory of chemistry for Inorganic/Organic Hybrid Functional Materials, College of Chemistry & Chemical Engineering, Anhui University, Hefei 230601, China.

A new tetraphenylethylene (TPE) functionalized 1,4-dihydropyrrolo[3,2-]pyrrole derivative () was synthesized with obvious aggregation-induced emission (AIE) active by simple synthetic method. exhibited reversible mechanofluorochromic (MFC) behavior. The powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM) investigations exhibited that the MFC nature is originated through a conversion from the microcrystalline to amorphous phase under the stimulus of external force. Read More

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December 2018

Spectroscopic Methods in the Evaluation of Modified Vegetable Base Oils from .

Molecules 2018 Dec 7;23(12). Epub 2018 Dec 7.

Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology, B. Krzywoustego 4, 44-100 Gliwice, Poland.

Raw vegetable oil from was subjected to oxidative treatment to enhance its viscosity. The oxidation processes were carried out in the presence of -hydroxyphthalimide with or without supercritical CO₂ as a solvent. Four spectroscopic techniques (Raman, UV-VIS, FT-IR, NMR) were applied to assess the chemical changes taking place during the oxidation. Read More

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December 2018

A Novel Class of Injectable Bioceramics that Glue Tissues and Biomaterials.

Materials (Basel) 2018 Dec 7;11(12). Epub 2018 Dec 7.

Applied material science, Department of Engineering, Uppsala University, Uppsala 75121, Sweden.

Calcium phosphate cements (CPCs) are clinically effective void fillers that are capable of bridging calcified tissue defects and facilitating regeneration. However, CPCs are completely synthetic/inorganic, unlike the calcium phosphate that is found in calcified tissues, and they lack an architectural organization, controlled assembly mechanisms, and have moderate biomechanical strength, which limits their clinical effectiveness. Herein, we describe a new class of bioinspired CPCs that can glue tissues together and bond tissues to metallic and polymeric biomaterials. Read More

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December 2018
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Ambient air pollution in gastrointestinal endoscopy unit; rationale and design of a prospective study.

Medicine (Baltimore) 2018 Dec;97(49):e13600

Department of Internal Medicine.

Background: A gastrointestinal endoscopy unit is frequently exposed to gastrointestinal gas expelled from patients and electrocoagulated tissue through carbonation for the treatment of gastrointestinal neoplasms or hemostasis of gastrointestinal bleeding. This can be potentially harmful to the health of not only the healthcare personnel but also patients who undergo endoscopic examinations. However, there has been scarce data on air quality in the endoscopy unit. Read More

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December 2018

Effects of organic molecules from biochar-extracted liquor on the growth of rice seedlings.

Ecotoxicol Environ Saf 2018 Dec 10;170:338-345. Epub 2018 Dec 10.

Liaoning Biochar Engineering & Technology Research Center, Shenyang Agricultural University, Shenyang 110866, PR China. Electronic address:

There are many reports indicating that biochar can promote growth; however, its mechanism of action remains unclear. The aim of this study was to show that organic molecules from biochar-extracted liquor affect the growth of rice seedlings. In this study, rice seedlings were cultured under water. Read More

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December 2018

Purification and characterization of a biosurfactant produced by Bacillus subtilis in cashew apple juice and its application in the remediation of oil-contaminated soil.

Colloids Surf B Biointerfaces 2018 Nov 27;175:256-263. Epub 2018 Nov 27.

Department of Chemical Engineering, Universidade Federal do Ceará, Brazil.

The ability of some microorganisms to use clarified cashew apple juice as carbon and energy source for biosurfactant production was assessed under strict controlled conditions. Twelve strains of Bacillus were isolated and evaluated regarding their biosurfactant production capabilities. The biosurfactant obtained with these selected strains showed the capacity of decreasing the surface tension of water from 72. Read More

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November 2018
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Highly efficient degradation of dimethyl phthalate from Cu(II) and dimethyl phthalate wastewater by EDTA enhanced ozonation: Performance, intermediates and mechanism.

J Hazard Mater 2018 Dec 3;366:378-385. Epub 2018 Dec 3.

State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science & Engineering, Tongji University, Shanghai, 200092, PR China; Shanghai Institute of Pollution Control and Ecological Security, 200092, Shanghai, PR China.

In this study, the presence of Cu(II) ions was found for the first time to severely inhibit +-dimethyl phthalate (DMP) degradation by ozone due to the formation of the stable complex Cu(II)-DMP. However, 100% DMP removal was rapidly reached when ethylenediamine tetraacetic acid (EDTA) was added with a Cu(II)/EDTA molar ratio of 3:1. Subsequent studies indicated that Cu(II)-DMP is sequestrated by EDTA, then DMP was degraded and Cu(II) was removed by precipitation. Read More

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December 2018

Photoluminescent properties in perylene PVD films: Influence of molecular aggregates and supramolecular arrangement.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 4;211:221-226. Epub 2018 Dec 4.

Department of Physics, School of Technology and Applied Sciences, São Paulo State University (UNESP), Presidente Prudente, SP, Brazil. Electronic address:

Organic thin films are at the forefront of basic studies and applications in the field of physics, chemistry, biochemistry and materials science. For example, the intrinsic supramolecular arrangement, or simply the formation of aggregates may alter the optical and electrical properties, which would impact the potential applications of the material. Here, an attempt is made to correlate the molecular structures of two perylene derivatives, bis butylimido perylene (BuPTCD) and bis phenethylimido perylene (PhPTCD), with their film formation, in particular, the supramolecular arrangement and the photoluminescent properties. Read More

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December 2018