332,896 results match your criteria Organic & biomolecular chemistry[Journal]


Reversible hydrogen adsorption on Li-decorated T-graphene flake: The effect of electric field.

J Mol Graph Model 2018 Dec 8;87:192-196. Epub 2018 Dec 8.

Department of Chemistry, College of Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran.

In the present work, we have studied a new allotrope of graphene, denoted as T-graphene (TG) flake as a versatile material in hydrogen storage. Recently, the metallic character of TG has been revealed. Our results show that the Li-decoration has a significant effect on the electronic properties of TG flake. Read More

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December 2018

Study on anti-hyperuricemia effects and active ingredients of traditional Tibetan medicine TongFengTangSan (TFTS) by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.

J Pharm Biomed Anal 2018 Nov 17;165:213-223. Epub 2018 Nov 17.

Jiangxi University of Traditional Chinese Medicine, No. 1688 Meiling Road, Nanchang, 330004, PR China. Electronic address:

TongFengTangSan (TFTS), a traditional Tibetan medicine comprising of Tinospora sinensis (TS), Terminalia chebula Retz (TC) and Trogopterori faeces (TF), is used to treat joint diseases like gout, gout arthritis, swelling, pain etc. Despite the significant therapeutic effects of TFTS, its pharmacological components have not been analyzed so far. Therefore, the chemical composition of the effective part of TFTS was analyzed by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS). Read More

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November 2018

Two-dimensional porphyrin-based covalent organic framework: A novel platform for sensitive epidermal growth factor receptor and living cancer cell detection.

Biosens Bioelectron 2018 Dec 7;126:734-742. Epub 2018 Dec 7.

College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450000, PR China. Electronic address:

A porphyrin-based covalent organic framework (denoted as p-COF) was synthesized by a simple oil-bath method and exploited as a novel sensing layer for immobilizing epidermal growth factor receptor (EGFR)-targeting aptamer strands to detect trace EGFR and living michigan cancer foundation-7 (MCF-7) cells for the first time. p-COF presented a nanosheet-like structure, large cavities, rich nitrogen-bearing groups, high electrochemical activity, excellent bioaffinity, low toxicity, and good stability in aqueous solution; the microstructural features of this material enabled strong immobilization of the aptamer strands. Interactions between the aptamer strands and EGFR significantly changed the electrochemical signals of the modified electrode due to the formation of an aptamer-EGFR complex. Read More

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December 2018

An acid-pasting approach towards perylenetetracarboxylic diimide based lithium/sodium ion battery cathodes with high rate performances.

J Colloid Interface Sci 2018 Nov 23;538:597-604. Epub 2018 Nov 23.

National Engineering Lab for TFT-LCD Materials and Technologies, Department of Electronic Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People's Republic of China. Electronic address:

An acid-pasting approach is developed in this work to fabricate the composite of perylenetetracarboxylic diimide (PTCDI) and carbon black in concentrated sulfuric acid. Different from traditional mechanical mixing, the solution-based fabrication strategy enables the sufficient blending of PTCDI as active component and carbon black as conductive agent in the PTCDI/CB composite. Serving as the cathode material, the PTCDI/CB composite shows excellent electrochemical performances in both lithium ion battery (137 mAh g at 100 mA g and 110 mAh g at 2000 mA g) and sodium ion battery (134 mAh g at 100 mA g and 99 mAh g at 1000 mA g), which are comparable to the state-of-art organic/inorganic cathode materials. Read More

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November 2018

Noble metal nanoparticle-functionalized Zr-metal organic frameworks with excellent photocatalytic performance.

J Colloid Interface Sci 2018 Dec 6;538:569-577. Epub 2018 Dec 6.

College of Chemical Engineering, Jiangsu Key Lab for the Chemistry & Utilization of Agricultural and Forest Biomass, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing, Jiangsu 210037, China. Electronic address:

Noble metal nanoparticles (NPs) functionalized MOFs are attractive materials for photocatalytic reactions, and outstanding catalytic performances can be expected, especially when they have intrinsically matched crystal faces between metals and MOFs. This study discovered that the photocatalytic oxidation of aromatic alcohols to aldehydes was enhanced over Au/UiO-66-NH or Au/UiO-66 but suppressed over Pt loaded counterparts, whereas the reduction of Cr(VI) was boosted over both two catalysts. In reactions, the conversion of benzyl alcohol was 17. Read More

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December 2018

Triphenyltin(IV) acylhydrazone compounds: Synthesis, structure and bioactivity.

J Inorg Biochem 2018 Nov 24;191:194-202. Epub 2018 Nov 24.

Institute of Anticancer Agents Development and Theranostic Application, The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China. Electronic address:

Four new triphenyltin(IV) acylhydrazone compounds of the type PhSnCHCHCONHN=R (where Ph = phenyl; R = isopropyl, isobutyl, cyclopentyl and cyclooctyl) were synthesized and characterized by elemental analysis, infrared spectrum (IR), nuclear magnetic resonance spectrum (NMR) and mass spectrum (MS). The crystal structures were determined and showed that tin atoms were four-coordinated and adopted a pseudo-tetrahedron configuration. Tin(IV) compounds show excellent bovine serum albumin (BSA) binding properties, and can oxidize nicotinamide-adenine dinucleotid (NADH) to generate reactive oxygen species (ROS), which inducing apoptosis effectively. Read More

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November 2018

Real-time dynamic analysis with low-field nuclear magnetic resonance of residual oil and sophorolipids concentrations in the fermentation process of Starmerella bombicola.

J Microbiol Methods 2018 Dec 12. Epub 2018 Dec 12.

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China. Electronic address:

The yeast Starmerella bombicola is known to produce sophorolipids (SLs) by fermentation method. In the fermentative production of SLs, at least three phases i.e. Read More

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December 2018

Blockade of nicotinic acetylcholine receptor enhances the responsiveness to bupropion in the mouse forced swim test.

Behav Brain Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, 23298, USA. Electronic address:

The objective of the present study is to investigate the role of α4, α5, α6 or β2 nAChR subunits in the antidepressant-like effect of bupropion. Adult male mice were treated with subcutaneous acute doses of bupropion (3 and 10 mg/kg) 30 min before the forced swim test (FST) in α4, α5, α6, or β2 nAChR subunit knockout (KO) and wild-type (WT) mice. In addition, the effects of β2* antagonist dihydro-β-erythroidine (DHβE, 3 mg/kg) on antidepressant-like effects of bupropion in C57BL/6 J mice were assessed. Read More

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December 2018

First-principles study of Aziridinium Lead Iodide Perovskite for Photovoltaics.

Chemphyschem 2018 Dec 15. Epub 2018 Dec 15.

South China University of Technology, Department of Physics, 381 Wushan Rd., 510640, Guangzhou, CHINA.

Long term stability remains one of the main challenges for the commercialization of rapidly developing hybrid organic-inorganic perovskite solar cells. Herein, we investigate the electronic and optical properties of a recently reported a much better stability hybrid halide perovskite (CH2)2NH2PbI3 (AZPbI3) than popular halide perovskits CH3NH3PbI3 and HC(NH2)2PbI3, using the density functional theory (DFT). We find that AZPbI3 possesses a band gap of 1. Read More

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December 2018

Impact of cell culture media additives on IgG glycosylation produced in CHO cells.

Biotechnol Bioeng 2018 Dec 15. Epub 2018 Dec 15.

Merck Life Sciences, Upstream R&D, Frankfurter Strasse 250, Darmstadt, Germany.

Glycosylation is a key critical quality attribute for monoclonal antibodies and other recombinant proteins because of its impact on effector mechanisms and half-life. In this study, a variety of compounds were evaluated for their ability to modulate glycosylation profiles of recombinant monoclonal antibodies produced in Chinese hamster ovary cells. Compounds were supplemented into the cell culture feed of fed-batch experiments performed with a CHO K1 and a CHO DG44 cell line expressing a recombinant IgG1. Read More

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December 2018

Effects of isoquinoline alkaloids from Macleaya cordata on physiological, immunological and inflammatory parameters in healthy beagles: Alkaloids in dog nutrition.

J Anim Physiol Anim Nutr (Berl) 2018 Dec 14. Epub 2018 Dec 14.

Institute of Animal Nutrition, Freie Universität Berlin, Berlin, Germany.

The aim of the study was to investigate nutritional, physiological and immunological effects of a plant-derived blend of isoquinoline alkaloids (Sangrovit® Extra) in healthy dogs. Two groups of healthy, adult beagles (N = 10) were tested in a cross-over experiment, lasting two consecutive three-week periods. The experimental group received 1. Read More

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December 2018

Comparable investigation of polyaniline behavior towards gaseous ammonia and toluene adsorption.

Environ Sci Pollut Res Int 2018 Dec 14. Epub 2018 Dec 14.

Chemical and Petrochemicals Engineering Department, Egypt-Japan University of Science and Technology, New Borg El-Arab Alexandria, Egypt.

With raising awareness of gaseous air pollutants and their harmful impact, adsorption is considered one of the most prominent techniques for gaseous emissions control. The usage of polyaniline as a gas adsorbent is an innovative idea. This work aims to compare the efficacy of synthesized polyaniline nanotubes (PANT) as a novel adsorbent towards inorganic gases (ammonia NH) and volatile organic compounds (toluene vapor). Read More

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December 2018

Selenium-Mercury Balance in Commercial Fish Species from the Turkish Waters.

Biol Trace Elem Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Fisheries Technology, Faculty of Aquatic Sciences, Istanbul University, Ordu st. No: 8, 34134 Laleli-Fatih, Istanbul, Turkey.

The interactions between selenium (Se) and mercury (Hg) were assessed in order to interpret public health risk, associated with dietary mercury exposure due to fish consumption. For this purpose, the mass and molar concentrations of Se and Hg were determined in the edible tissues of six species of fish, collected from the commercial fishing grounds of Turkey. The Se/Hg molar ratios and selenium health benefit values (Se-HBVs) were also calculated. Read More

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December 2018

Antiproliferative Effect of a Novel 4,4'-Disulfonyldiarylidenyl Piperidone in Human Colon Cancer Cells.

Cell Biochem Biophys 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiology and Medicine, Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College, 1 Medical Center Drive, 601 Rubin Building, Lebanon, NH, 03756, USA.

The synthesis and antiproliferative effect of a novel curcumin analog, 4,4'-disulfonyldiarylidenyl piperidone, are reported. The design of the molecule is based on the fusion of an antiproliferative segment, namely diarylidenyl piperidone (DAP), with N-hyroxypyrroline, which is known to metabolically convert to nitroxide and protect healthy cells. Cellular uptake, metabolic conversion, cytotoxicity and antiproliferative effect of the DAP derivative against HCT-116 human colon cancer cells have been determined. Read More

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December 2018

5-Amino-pyrazoles: potent reagents in organic and medicinal synthesis.

Mol Divers 2018 Dec 14. Epub 2018 Dec 14.

Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran.

5-Amino-pyrazoles have proven to be a class of fascinating and privileged organic tools for the construction of diverse heterocyclic or fused heterocyclic scaffolds. This review presents comprehensively the applications of 5-amino-pyrazoles as versatile synthetic building blocks in the synthesis of remarkable organic molecules with an emphasis on versatile functionalities. Following a brief introduction of synthesis methods, planning strategies to construct organic compounds, particularly diverse heterocyclic scaffolds, such as poly-substituted heterocyclic compounds and fused heterocyclic compounds via 5-amino-pyrazoles, have been summarized. Read More

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December 2018

Application of anisotropic NMR parameters to the confirmation of molecular structure.

Nat Protoc 2018 Dec 14. Epub 2018 Dec 14.

Structure Elucidation Group, Process and Analytical Research and Development, Merck Research Laboratories, Rahway, NJ, USA.

The use of anisotropic NMR data, such as residual dipolar couplings (RDCs) and residual chemical shift anisotropies (RCSAs), has emerged as a powerful technique for structural characterization of organic small molecules. RDCs typically report the relative orientations of different H-C bonds; RCSAs report the relative orientations of different carbon chemical shielding tensors and hence are more useful for proton-deficient molecules. This information is complementary to that obtained from conventional NMR data such as J couplings, isotropic chemical shifts, and nuclear Overhauser effects (NOEs)/rotational frame nuclear Overhauser effects (ROEs). Read More

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December 2018

Publisher Correction: Antimicrobial spray nanocoating of supramolecular Fe(III)-tannic acid metal-organic coordination complex: applications to shoe insoles and fruits.

Sci Rep 2018 Dec 14;8(1):17961. Epub 2018 Dec 14.

Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 34141, Korea.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

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December 2018

Novel Polyheteroarylene Membranes for Separation of Methanol‒Hexane Mixture by Pervaporation.

Sci Rep 2018 Dec 14;8(1):17849. Epub 2018 Dec 14.

Department of Chemical Thermodynamics and Kinetics, Saint Petersburg State University, Saint Petersburg, 198504, Russia.

Polymer membranes with improved transport properties are required for effective separation of organic mixtures (such as methanol‒hexane system) by combination of pervaporation and azeotropic distillation. The present work is devoted to comparative study of two types of membranes based on poly(amidoimide acid) with 2,2'-biquinoline-6,6' units in the backbone; the objects were prepared (i) from the initial polymer and (ii) from the polymer-metal complex (with Cu(I)). Thermo-mechanical and mass spectrometric investigations demonstrated good operational properties of the samples. Read More

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December 2018

Overall water splitting by graphdiyne-exfoliated and -sandwiched layered double-hydroxide nanosheet arrays.

Nat Commun 2018 Dec 14;9(1):5309. Epub 2018 Dec 14.

Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.

It is of great urgency to develop efficient, cost-effective, stable and industrially applicable electrocatalysts for renewable energy systems. But there are still few candidate materials. Here we show a bifunctional electrocatalyst, comprising graphdiyne-exfoliated and -sandwiched iron/cobalt layered double-hydroxide nanosheet arrays grown on nickel foam, for the oxygen and hydrogen evolution reactions. Read More

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December 2018

Fluorine-free water-in-ionomer electrolytes for sustainable lithium-ion batteries.

Nat Commun 2018 Dec 14;9(1):5320. Epub 2018 Dec 14.

Helmholtz Institute Münster - Forschungszentrum Jülich GmbH (IEK 12), Corrensstrasse 46, 48149 Münster, D-48149, Münster, Germany.

The continuously increasing number and size of lithium-based batteries developed for large-scale applications raise serious environmental concerns. Herein, we address the issues related to electrolyte toxicity and safety by proposing a "water-in-ionomer" type of electrolyte which replaces organic solvents by water and expensive and toxic fluorinated lithium salts by a non-fluorinated, inexpensive and non-toxic superabsorbing ionomer, lithium polyacrylate. Interestingly, the electrochemical stability window of this electrolyte is extended greatly, even for high water contents. Read More

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December 2018

survival duration in manure-amended soils is affected by spatiotemporal, agricultural, and weather factors: a multi-season, multi-site field study in the Mid-Atlantic U.S.

Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.

University of Maryland Eastern Shore Department of Agriculture, Princess Anne, MD.

Untreated biological soil amendments of animal origin (BSAAO), like manure, are commonly used to fertilize soils for growing fruit and vegetable crops, and can contain enteric bacterial foodborne pathogens. Little is known about the comparative longitudinal survival of pathogens in agricultural fields containing different types of BSAAO, and field data may be useful to determine intervals between manure application and harvest of produce intended for human consumption to minimize foodborne illness. This study generated 324 survival profiles from 12 different field trials at three different sites (UMES, PA, BARC) in the Mid-Atlantic U. Read More

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December 2018

wall teichoic acids is required for biofilm formation and root colonization.

Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.

Jiangsu Provincial Key Lab for Organic Solid Waste Utilization, National Engineering Research Center for Organic-based Fertilizers, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, Nanjing Agricultural University, 210095, China.

The rhizosphere colonization by plant growth-promoting rhizobacterium (PGPR) along plant roots facilitates the ability of PGPRs to promote plant growth and health. Thus, an understanding of the molecular mechanisms of the root colonization process by plant-beneficial strains is essential for the use of these strains in agriculture. Here we observed that an gene mutant of a plant-growth-promoting rhizobacterium, velezensis SQR9 was unable to form normal biofilm architecture, and differential protein expression was observed by proteomic analysis. Read More

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December 2018

Structural and computational basis for potent inhibition of glutamate carboxypeptidase II by carbamate-based inhibitors.

Bioorg Med Chem 2018 Nov 14. Epub 2018 Nov 14.

Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, MD 21205, United States; Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, United States. Electronic address:

A series of carbamate-based inhibitors of glutamate carboxypeptidase II (GCPII) were designed and synthesized using ZJ-43, N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]-l-glutamic acid, as a molecular template in order to better understand the impact of replacing one of the two nitrogen atoms in the urea-based GCPII inhibitor with an oxygen atom. Compound 7 containing a C-terminal 2-oxypentanedioic acid was more potent than compound 5 containing a C-terminal glutamic acid (2-aminopentanedioic acid) despite GCPII's preference for peptides containing an N-terminal glutamate as substrates. Subsequent crystallographic analysis revealed that ZJ-43 and its two carbamate analogs 5 and 7 with the same (S,S)-stereochemical configuration adopt a nearly identical binding mode while (R,S)-carbamate analog 8 containing a d-leucine forms a less extensive hydrogen bonding network. Read More

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November 2018

On-line coupling of hydrophobic interaction column with reverse phase column -charged aerosol detector/mass spectrometer to characterize polysorbates in therapeutic protein formulations.

J Chromatogr A 2018 Dec 5. Epub 2018 Dec 5.

Analytical R&D, Pfizer BioTherapeutics R&D Pharmaceutical Sciences, 700 Chesterfield Parkway West, Chesterfield, MO 63017, United States.

Polysorbates are complex mixtures of over a thousand components with a wide range of hydrophobicity. This paper describes a methodology for characterization of heterogeneity and stability of polysorbates in therapeutic protein formulation. The method utilizes on-line coupling of a hydrophobic interaction chromatography (HIC) column with reverse phase liquid chromatography (RPLC) and charged aerosol detection (CAD)/mass spectrometer (MS). Read More

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December 2018

Synthesis, biological evaluation and molecular docking study of 1,2,3-1H-triazoles having 4H-pyrano[2,3-d]pyrimidine as potential Mycobacterium tuberculosis protein tyrosine phosphatase B inhibitors.

Bioorg Med Chem Lett 2018 Dec 6. Epub 2018 Dec 6.

Faculty of Chemistry, VNU University of Science, 19 Le Thanh Tong, Ha Noi, Viet Nam; Thai Nguyen College of Education, Quang Trung, Thinh Dan, Thai Nguyen, Viet Nam.

Some heterocycles, namely 2-amino-4H-pyran-3-carbonitriles, were synthesized in a three-component reaction from substituted benzaldehydes, malononitrile, and ethyl acetoacetate. These heterocycles have been converted subsequently into 4H-pyrano[2,3-d]pyrimidine ring by ring-closing reaction with acetic anhydride in the presence of the concentrated sulfuric acid as catalyst. The successive alkylation reaction of lactam NH bond on pyrimidine-4-one ring was carried out using propargylic bromide in dry acetone in the presence of anhydrous potassium carbonate. Read More

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December 2018

MS/MS-Based Molecular Networking Approach for the Detection of Aplysiatoxin-Related Compounds in Environmental Marine Cyanobacteria.

Mar Drugs 2018 Dec 13;16(12). Epub 2018 Dec 13.

Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, Singapore 637616, Singapore.

Certain strains of cyanobacteria produce a wide array of cyanotoxins, such as microcystins, lyngbyatoxins and aplysiatoxins, that are associated with public health issues. In this pilot study, an approach combining LC-MS/MS and molecular networking was employed as a rapid analytical method to detect aplysiatoxins present in four environmental marine cyanobacterial samples collected from intertidal areas in Singapore. Based on 16S-ITS rRNA gene sequences, these filamentous cyanobacterial samples collected from Pulau Hantu were determined as , sp. Read More

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December 2018

Recent Developments of Useful MALDI Matrices for the Mass Spectrometric Characterization of Lipids.

Biomolecules 2018 Dec 13;8(4). Epub 2018 Dec 13.

Faculty of Medicine, Institute for Medical Physics and Biophysics, Härtelstr. 16/18, Leipzig University, D-04107 Leipzig, Germany.

Matrix-assisted laser desorption/ionization (MALDI) is one of the most successful "soft" ionization methods in the field of mass spectrometry and enables the analysis of a broad range of molecules, including lipids. Although the details of the ionization process are still unknown, the importance of the matrix is commonly accepted. Both, the development of and the search for useful matrices was, and still is, an empirical process, since properties like vacuum stability, high absorption at the laser wavelength, etc. Read More

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December 2018

Synthesis and Properties of Magnetic Aryl-Imidazolium Ionic Liquids with Dual Brønsted/Lewis Acidity.

Materials (Basel) 2018 Dec 13;11(12). Epub 2018 Dec 13.

Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, Yunlin 64002, Taiwan.

A series of unique tunable aryl-imidazolium magnetic ionic liquids (MILs) with dual acidity that contain both Brønsted and Lewis acidic sites (abbreviated as B-L MILs) were synthesized and characterized using nuclear magnetic resonance and mass spectrometry. Physical properties, such as thermal properties, magnetic susceptibility, and Brønsted and Lewis acidity, were measured. These properties were found to depend on the cation structure. Read More

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December 2018

Microfluidic Preconcentration Chip with Self-Assembled Chemical Modified Surface for Trace Carbonyl Compounds Detection.

Sensors (Basel) 2018 Dec 13;18(12). Epub 2018 Dec 13.

R&D Center of HealthCare Electronics, Institute of Microelectronics of Chinese Academy of Sciences, Beijing 100029, China.

Carbonyl compounds in water sources are typical characteristic pollutants, which are important indicators in the health risk assessment of water quality. Commonly used analytical chemistry methods face issues such as complex operations, low sensitivity, and long analysis times. Here, we report a silicon microfluidic device based on click chemical surface modification that was engineered to achieve rapid, convenient and efficient capture of trace level carbonyl compounds in liquid solvent. Read More

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December 2018

Polysaccharides from Portulaca oleracea L. regulated insulin secretion in INS-1 cells through voltage-gated Na channel.

Biomed Pharmacother 2019 Jan 5;109:876-885. Epub 2018 Nov 5.

School of Life science, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi, 330013, PR China. Electronic address:

The present study was undertaken to determine the involvement of voltage-gated Na channel (VGSC) and other mechanism related to insulin secretion in polysaccharides from Portulaca oleracea L. (POP)-induced secretion of insulin from insulin-secreting β-cell line cells (INS-1) cells. Our results showed that the concentration of insulin both in culture medium and inside INS-1 cells were increased under the existing of different concentration of glucose by POP or TTX, respectively. Read More

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January 2019

Comparison of antidiabetic effects of saponins and polysaccharides from Momordica charantia L. in STZ-induced type 2 diabetic mice.

Biomed Pharmacother 2019 Jan 5;109:744-750. Epub 2018 Nov 5.

Guangdong Provincial Key Laboratory of Marine Biotechnology, STU-UNIVPM Joint Algal Research Center, Department of Biology, College of Science, Shantou University, Shantou, Guangdong 515063, PR China. Electronic address:

Saponins as small organic molecules and polysaccharides as biomacromolecules are the main bioactive substances of Momordica charantia L. (M. charantia) with anti-hyperglycemic activities. Read More

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January 2019

α, β-Amyrin, a pentacyclic triterpenoid from Protium heptaphyllum suppresses adipocyte differentiation accompanied by down regulation of PPARγ and C/EBPα in 3T3-L1 cells.

Biomed Pharmacother 2019 Jan 26;109:1860-1866. Epub 2018 Nov 26.

Department of Physiology and Pharmacology, Natural Products Laboratory, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address:

Previous studies have reported the anti-obesity effects of α, β-Amyrin in high fat-fed mice. This study aimed to evaluate whether α, β-Amyrin has an anti-adipogenic effect in 3T3-L1 murine adipocytes and to explore the possible underlying mechanisms. 3T3-L1 pre-adipocytes were differentiated in a medium containing insulin, dexamethasone, and 1-methyl-3-isobutylxanthine. Read More

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January 2019

Poly(ε-caprolactone) modified organic dyes nanoparticles for noninvasive long term fluorescence imaging.

Colloids Surf B Biointerfaces 2019 Jan 25;173:884-890. Epub 2018 Oct 25.

State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Electronic address:

Application of organic dyes is limited in biomedical fields due to the rapid self-quenching, poor stability and water solubility. In this work, polymer modified organic dyes is developed through the dyes initiating polymerization. The polymer length is studied by tuning the amount of monomer. Read More

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January 2019

Filter paper grafted with epoxide-based copolymer brushes for activation-free peptide nucleic acid conjugation and its application for colorimetric DNA detection.

Colloids Surf B Biointerfaces 2019 Jan 27;173:851-859. Epub 2018 Sep 27.

Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok, 10330, Thailand; Center of Excellence in Materials and Bio-interfaces, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok 10330, Thailand. Electronic address:

Epoxide-bearing filter paper was first prepared by surface-initiated reversible addition-fragmentation chain transfer (RAFT) copolymerization of glycidyl methacrylate (GMA) and poly(ethylene glycol)methacrylate (PEGMA). Without the need for activation step, the capture peptide nucleic acid (PNA) probes carrying a C-terminal lysine modification can be directly immobilized on the surface-grafted poly[glycidyl methacrylate-ran-poly(ethylene glycol)methacrylate] (P(GMA-ran-PEGMA)) through ring-opening of epoxide groups in the GMA repeating units by amino groups in the PNA's structure. The success of P(GMA-ran-PEGMA) grafting on the filter paper and subsequent PNA immobilization was confirmed by fluorescence microscopy, Fourier transform-infrared spectroscopy and X-ray photoelectron spectroscopy. Read More

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January 2019

Magnetofluorescent nanohybrid comprising polyglycerol grafted carbon dots and iron oxides: Colloidal synthesis and applications in cellular imaging and magnetically enhanced drug delivery.

Colloids Surf B Biointerfaces 2019 Jan 27;173:842-850. Epub 2018 Oct 27.

State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China. Electronic address:

Multifunctional nanohybrids are attracting increasing attention for potential biomedical applications such as bioimaging and drug delivery due to their combined advantages of individual components. However, challenges in the improvement of their synthesis and colloidal stability to facilitate practical biomedical applications still remain. In this work, we report an efficient synthetic approach to fabricate magnetofluorescent nanohybrid (IO-PG-CD) comprising fluorescent carbon dots (CDs) and magnetic iron oxide nanoparticles (IOs) through polyglycerol (PG) mediated covalent linkage in aqueous media. Read More

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January 2019

Polychaete mucopolysaccharide alters sediment microbial diversity and stimulates ammonia-oxidising functional groups.

FEMS Microbiol Ecol 2018 Dec 14. Epub 2018 Dec 14.

Marine Biological Association of the United Kingdom, The Laboratory, Citadel Hill, Plymouth, PL1 2PB.

Sediment nitrogen cycling is a network of microbially-mediated biogeochemical processes that are vital in regulating ecosystem functioning. Mucopolysaccharides (mucus) are produced by many invertebrates and have the potential to be an important source of organic carbon and nitrogen to sediment microorganisms. At present, we have limited understanding of how mucopolysaccharide moderates total sediment microbial communities and specific microbial functional groups that drive nitrogen cycling processes. Read More

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December 2018
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Pilot Studies of VOC Exposure Profiles during Surgical Operations.

Ann Work Expo Health 2018 Dec 14. Epub 2018 Dec 14.

Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan, R.O.C.

Volatile organic chemical exposure resulting from surgical operations is common in operating room personnel. The potential risk of long-term exposure to these low-level chemicals is always a concern. This study was conducted in an area hospital located in northern Taiwan to investigate the internal exposure scenario for operating room personnel. Read More

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December 2018

A decision tree-based integrated testing strategy for tailor-made carcinogenicity evaluation of test substances using genotoxicity test results and chemical spaces.

Mutagenesis 2018 Dec 14. Epub 2018 Dec 14.

R&D, Safety Science Research, Kao Corporation, Ichikai-Machi, Haga-Gun, Tochigi, Japan.

Genotoxicity evaluation has been widely used to estimate the carcinogenicity of test substances during safety evaluation. However, the latest strategies using genotoxicity tests give more weight to sensitivity; therefore, their accuracy has been very low. For precise carcinogenicity evaluation, we attempted to establish an integrated testing strategy for the tailor-made carcinogenicity evaluation of test materials, considering the relationships among genotoxicity test results (Ames, in vitro mammalian genotoxicity and in vivo micronucleus), carcinogenicity test results and chemical properties (molecular weight, logKow and 179 organic functional groups). Read More

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December 2018

Mass spectrometry imaging of low molecular weight metabolites in strawberry fruit (Fragaria x ananassa Duch.) cv. Primoris with Ag nanoparticle enhanced target.

Phytochemistry 2018 Dec 11;159:11-19. Epub 2018 Dec 11.

Rzeszów University of Technology, Faculty of Chemistry, 6 Powstańców Warszawy Ave., 35-959, Rzeszów, Poland.

Strawberry (Fragaria x ananassa Duch., Rosaceae) is the subject of many research studies due to its numerous features such as unique taste, aroma and health qualities. The distribution of low molecular weight metabolites belonging to aldehydes, ketones, alcohols, esters, organic acids, phenolics, amino acids and sugars classes within strawberry fruit cross-section was studied using mass spectrometry imaging (MSI) method with Ag nanoparticle enhanced target (AgNPET). Read More

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December 2018

A multi-site approach to investigate the role of toxicity and confounding factors on plant bioassay results.

Chemosphere 2018 Dec 3;219:482-492. Epub 2018 Dec 3.

Bordeaux INP, G&E, EA 4592, F-33600, Pessac, France; Univ. Bordeaux Montaigne, G&E, EA 4592, F-33600, Pessac, France.

Development of organisms that live on contaminated soils depends on toxicity as well as several physical and chemical soil properties. We aimed to identify plant bioassays most responsive to contaminants and not to confounding factors due to soil type differences. We implemented a multi-site approach in seven contaminated sites and used different ordinary plant bioassays (fourteen-day-shoot biomass and five-day-root and shoot elongation). Read More

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December 2018

Significant inhibition of photosynthesis and respiration in leaves of Cucumis sativus L. by oxybenzone, an active ingredient in sunscreen.

Chemosphere 2018 Dec 3;219:456-462. Epub 2018 Dec 3.

State Key Laboratory of Crop Biology, China; College of Life Sciences, Shandong Agricultural University, China. Electronic address:

Oxybenzone (OBZ), an active ingredient in most sunscreens, was recently shown to be toxic to humans, corals and other animals. This study is the first to demonstrate that OBZ can significantly inhibit photosynthesis and respiration in the leaves of a higher plant, cucumber. An OBZ suspension content as low as 0. Read More

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December 2018
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Application of an emulsified polycolloid substrate biobarrier to remediate petroleum-hydrocarbon contaminated groundwater.

Chemosphere 2018 Dec 5;219:444-455. Epub 2018 Dec 5.

Institute of Environmental Engineering, National Sun Yat-Sen University, Kaohsiung, Taiwan. Electronic address:

Emulsified polycolloid substrate (EPS) was developed and applied in situ to form a biobarrier for the containment and enhanced bioremediation of a petroleum-hydrocarbon plume. EPS had a negative zeta potential (-35.7 mv), which promoted its even distribution after injection. Read More

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December 2018

Spatial distribution and source identification of hydrophobic organic compounds (HOCs) on sedimentary microplastic in Hong Kong.

Chemosphere 2018 Dec 7;219:418-426. Epub 2018 Dec 7.

Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Hong Kong Special Administrative Region; State Key Laboratory in Marine Pollution, City University of Hong Kong, Tat Chee Avenue, Hong Kong Special Administrative Region. Electronic address:

The spatial distribution, composition and source of hydrophobic organic compounds (HOCs) including polyaromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and organochlorinated pesticides (OCPs) of the sedimentary microplastics (0.25-5 mm) in Hong Kong were investigated. The concentration of ΣPAHs ranged between 70. Read More

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December 2018
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Fabrication of ploydopamine-kaolin supported Ag nanoparticles as effective catalyst for rapid dye decoloration.

Chemosphere 2018 Dec 7;219:400-408. Epub 2018 Dec 7.

College of Environmental Science and Engineering, Hunan University and Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha, 410082, PR China.

In this work, silver nanoparticles supported on polydopamine-kaolin composite (PDA-kaolin-Ag) was fabricated by an in-situ reduction method with PDA as both reductant and stabilizer. The morphology, composition, and structure of PDA-kaolin-Ag composite were characterized by transmission electron microscopy (TEM), X-ray powder diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The catalytic reduction tests confirmed the importance of PDA modification and high catalytic activities of this as-prepared PDA-kaolin-Ag composite towards a model dye Rhodamine B. Read More

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December 2018
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Metals geochemistry and ecological risk assessment in a tropical mangrove (Can Gio, Vietnam).

Chemosphere 2018 Nov 30;219:365-382. Epub 2018 Nov 30.

Department of Analytical Chemistry, Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City, Viet Nam; Faculty of Chemical Engineering and Food Technology, Nguyen Tat Thanh University, Viet Nam.

Mangrove sediments act as natural biogeochemical reactors, modifying metals partitioning after their deposition. The objectives of the present study were: to determine distribution and partitioning of metals (Fe, Mn, Ni, Cr, Cu, Co and As) in sediments and pore-waters of Can Gio Mangrove; and to assess their ecological risks based on Risk Assessment Code. Three cores were collected within a mudflat, beneath Avicennia alba and Rhizophora apiculata stands. Read More

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November 2018
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Use of iron ore tailing from tailing dam as catalyst in a fenton-like process for methylene blue oxidation in continuous flow mode.

Chemosphere 2018 Dec 7;219:328-334. Epub 2018 Dec 7.

Reseacher at Federal University of Minas Gerais, Chemistry Department, Av. Pres. Antônio Carlos, 6627 - Pampulha, Belo Horizonte, MG, 31270-901, Brazil. Electronic address:

The global demand for iron ore with high iron contents to supply the steel industry is associated, in most countries, with the generation of tailings from mineral processing. The chemical compositions of iron ore tailings (basically FeO and SiO) make them an excellent candidate as a catalyst for advanced oxidation processes (AOPs), especially the Fenton process and its derivatives. Therefore, this paper aimed to transform iron ore tailings from tailing dams into catalysts able to activate HO for the purpose of treating, in a continuous flow, effluents contaminated with organic dyes, employing methylene blue as a model molecule. Read More

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December 2018
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Enhancement of excess sludge hydrolysis and decomposition with different lysozyme dosage.

J Hazard Mater 2018 Dec 3;366:395-401. Epub 2018 Dec 3.

School of Environment, Harbin Institute of Technology, Harbin 150090, China.

The performance of the lysozyme catalysis on excess sludge (ES) hydrolysis and decomposition was investigated in this study. For this purpose, the release of soluble organic matters from sludge flocs, extracellular polymeric substances (EPS) changes in composition and distribution and the quantity variations of microorganisms were monitored. Results indicated that lysozyme boosted the ES hydrolysis significantly with approximately 236. Read More

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December 2018

A new class of diamide scaffold: Design, synthesis and biological evaluation as potent antimitotic agents, tubulin polymerization inhibition and apoptosis inducing activity studies.

Bioorg Chem 2018 Dec 5;84:399-409. Epub 2018 Dec 5.

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

A new series of diamide functional compounds has been designed, synthesized and confirmed by spectroscopic methods and elemental analyses. All the synthesized compounds were evaluated for their antiproliferative activity on HepG2 cell line. Compounds 3k and 3l were proved to have potent anticancer activity equipotent or more potent than reference compound Combretastatin A-4. Read More

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December 2018

Below- and aboveground production in cocoa monocultures and agroforestry systems.

Sci Total Environ 2018 Dec 5;657:558-567. Epub 2018 Dec 5.

Forschungsinstitut für Biologischen Landbau (FiBL), Department of International Cooperation, Ackerstrasse 113, Postfach 219, 5070 Frick, Switzerland.

Farmers expect yield reduction of cash crops like cocoa when growing in agroforestry systems compared to monocultures, due to competition for resources, e.g. nutrients and water. Read More

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December 2018

Multivariate analysis and modeling of soil quality indicators in long-term management systems.

Sci Total Environ 2018 Dec 4;657:457-465. Epub 2018 Dec 4.

Department of Plant Production, São Paulo State University-UNESP, 14884-900 Jaboticabal, SP, Brazil. Electronic address:

Soil management systems, as well as the long-term application of nitrogen fertilization, might promote changes in soil quality (SQ). The knowledge of how agronomic practices influence SQ is the main factor in the development of most sustainable management systems. Thus, the aim of this study was to evaluate the influence of long-term management systems on SQ through the analysis of 10 soil quality indicators (SQIs), to select the most sensitive SQIs through principal components analysis (PCA) and to propose a mathematical model that could estimate the activities of enzymes based on SQI values with simple and low-cost procedures in relation to enzyme measurement. Read More

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December 2018