Cloning and expression study of an IRF4a gene and its two transcript variants in turbot, Scophthalmus maximus.
Fish Shellfish Immunol 2017 Oct 17. Epub 2017 Oct 17.
College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China.
Interferon regulatory factor 4 (IRF4) is known to be involved in antiviral response as well as regulation of functional and developmental processes in lymphomyeloid cell lineages in mammals. In this study, the gene of IRF4a and its two transcript variants (named IRF4a1 and -2) were cloned from turbot, Scophthalmus maximus, the tissue distributions and in vivo immune responsive expression patterns of the two transcripts were subsequently examined. The Scophthalmus maximus (Sm)IRF4a gene is 8367 nucleotide (nt) in length, consisting of eight exons and seven introns. Read More