3,043 results match your criteria Orchitis


Segmental testicular infarction, a rare complication of epididymo-orchitis.

Urol Case Rep 2020 Sep 15;32:101246. Epub 2020 May 15.

Nepean Urology Research Group, Kingswood, NSW, 2747, Australia.

Segmental infarction of the testicle secondary to epididymo-orchitis is a rare condition which can be difficult to diagnose and can lead to loss of the testis. We report a case of a 72-year-old man who presented with two weeks of worsening pain of his left testis despite oral antibiotic treatment for epididymo-orchitis. A testicular ultrasound initially revealed a suspected intra-testicular abscess. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eucr.2020.101246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256310PMC
September 2020

Prior and novel coronaviruses, Coronavirus Disease 2019 (COVID-19), and human reproduction: what is known?

Fertil Steril 2020 Jun 16;113(6):1140-1149. Epub 2020 Apr 16.

Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia. Electronic address:

Objective: To summarize current understanding of the effects of novel and prior coronaviruses on human reproduction, specifically male and female gametes, and in pregnancy.

Design: Review of English publications in PubMed and Embase to April 6, 2020.

Method(s): Articles were screened for reports including coronavirus, reproduction, pathophysiology, and pregnancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fertnstert.2020.04.025DOI Listing

No evidence of severe acute respiratory syndrome-coronavirus 2 in semen of males recovering from coronavirus disease 2019.

Fertil Steril 2020 Jun 17;113(6):1135-1139. Epub 2020 Apr 17.

Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah. Electronic address:

Objective: To describe detection of severe acute respiratory syndrome (SARS)-coronavirus 2 (CoV-2) in seminal fluid of patients recovering from coronavirus disease 2019 (COVID-19) and to describe the expression profile of angiotensin-converting enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2) within the testicle.

Design: Observational, cross-sectional study.

Setting: Tertiary referral center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fertnstert.2020.04.024DOI Listing

SARS-CoV-2 infection, male fertility and sperm cryopreservation: a position statement of the Italian Society of Andrology and Sexual Medicine (SIAMS) (Società Italiana di Andrologia e Medicina della Sessualità).

J Endocrinol Invest 2020 May 27. Epub 2020 May 27.

Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.

Purpose: The recent pandemic of severe acute respiratory syndrome (SARS) due to coronavirus (CoV) 2 (SARS-CoV-2) has raised several concerns in reproductive medicine. The aim of this review is to summarize available evidence providing an official position statement of the Italian Society of Andrology and Sexual Medicine (SIAMS) METHODS: A comprehensive Pubmed, Web of Science, Embase, Medline and Cochrane library search was performed. Due to the limited evidence and the lack of studies, it was not possible to formulate recommendations according to the Oxford 2011 Levels of Evidence criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40618-020-01290-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252417PMC

A case of xanthogranulomatous orchitis and its preoperative diagnostic challenges.

Urol Case Rep 2020 Sep 15;32:101248. Epub 2020 May 15.

Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar.

Xanthogranulomatous orchitis (XGO) is an extremely rare inflammatory disease of the testis which can mimic testicular tumors. We report a 42-year-old man who presented with left scrotal swelling for one-month duration associated with pus discharge from the overlying scrotal skin. Scrotal ultrasonography revealed an atrophic heterogenous left testis with scrotal wall collection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eucr.2020.101248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243048PMC
September 2020

Bilateral Optic Neuritis: A Rare Complication of Mumps.

Cureus 2020 Apr 21;12(4):e7768. Epub 2020 Apr 21.

Pediatrics, United Medical and Dental College, Creek General Hospital, Karachi, PAK.

Mumps is a contagious viral illness that classically presents with fever, parotid gland swelling, headache, and vomiting in unimmunized children. The complications of mumps most commonly include orchitis, pancreatitis, encephalitis, and meningitis. Optic neuritis, which refers to the inflammation of the optic nerve, in rare cases, can present after mumps meningoencephalitis and causes pain in the eye, and a decrease in visual acuity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243626PMC

Protective effect of Alpha-Linolenic acid on Lipopolysaccharide-Induced Orchitis in mice.

Andrologia 2020 May 26:e13667. Epub 2020 May 26.

Urology Department, Cukurova University Medical Faculty, Adana, Turkey.

Previous studies have demonstrated that polyunsaturated fatty acids (PUFAs) have anti-inflammatory effects. One specific PUFA, alpha-linolenic acid (ALA), shows both anti-inflammatory and antioxidant properties. In the testes, inflammatory mediators are known to increase when orchitis is induced by bacterial lipopolysaccharide (LPS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/and.13667DOI Listing

Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): an open-label, parallel-group, randomised controlled trial.

Lancet Diabetes Endocrinol 2020 Jun;8(6):477-489

Department of Medicine, Weill Cornell Medicine Qatar, Qatar Foundation, Doha, Qatar; Qatar Metabolic Institute, Hamad Medical Corporation, Doha, Qatar.

Background: Type 2 diabetes is affecting people at an increasingly younger age, particularly in the Middle East and in north Africa. We aimed to assess whether an intensive lifestyle intervention would lead to significant weight loss and improved glycaemia in young individuals with early diabetes.

Methods: This open-label, parallel-group, randomised controlled trial (DIADEM-I), done in primary care and community settings in Qatar, compared the effects of an intensive lifestyle intervention with usual medical care on weight loss and glycaemic outcomes in individuals with type 2 diabetes, aged 18-50 years, with a short diabetes duration (≤3 years), had a BMI of 27·0 kg/m or more, and who were from the Middle East and north Africa region. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-8587(20)30117-0DOI Listing

Pulmonary and systemic involvement of COVID-19 assessed by ultrasound-guided minimally invasive autopsy.

Histopathology 2020 May 22. Epub 2020 May 22.

BIAS - Brazilian Image Autopsy Study Group, Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil.

Aims: Brazil ranks high in the number of COVID-19 cases and COVID-19's mortality rate. In this context, autopsies are important to confirm the disease, determine associated conditions, and study the pathophysiology of this novel disease. In order to follow biosafety recommendations, we used Ultrasound-Guided Minimally Invasive Autopsy (MIA-US) to assess the systemic involvement of COVID-19 and present the results of ten initial autopsies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/his.14160DOI Listing

Identification and description of mumps cases in a non-outbreak setting and evaluation of the effectiveness of mumps-containing vaccines over time.

Hum Vaccin Immunother 2020 May 13:1-5. Epub 2020 May 13.

Vaccine Study Center, Division of Research, Kaiser Permanente, Oakland, CA, USA.

Mumps outbreaks among previously vaccinated young adults raise concerns regarding waning vaccine immunity. This study identified, described and assessed the changing incidence of mumps cases following mumps-containing vaccination (MMR/MMRV) in a non-mumps outbreak setting. Potential cases between 1996 and 2018 were identified by the international classification of disease codes or by mumps laboratory test orders among Kaiser Permanente Northern California members. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21645515.2020.1756153DOI Listing

Is Non-Chlamydial Non-Gonococcal Urethritis Associated with Significant Clinical Complications in Men? A Systematic Review.

Curr Urol 2020 Mar 20;14(1):1-13. Epub 2020 Mar 20.

East and North Hertfordshire NHS Trust, Department of Urology, Lister Hospital, Stevenage.

Background: It is estimated that between 50 and 89% of non-gonococcal urethritis is not caused by . Associations between non-chlamydial non-gonococcal urethritis (NCNGU) with balanoposthitis, epididymo-orchitis and reactive arthritis have been suggested, but evidence to support these often-theoretical relationships is sparse and further investigation is called for. Concerns over increasing antimicrobial resistance has rendered the need for clarity over this question ever more pressing in recent years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206600PMC

Region-specific immune responses to autoimmune epididymitis in the murine reproductive tract.

Cell Tissue Res 2020 May 8. Epub 2020 May 8.

Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Victoria, Australia.

Epididymitis is a common pathology of the male reproductive tract, potentially leading to infertility. Studies on bacterial epididymitis indicate that the cauda epididymis is more susceptible to inflammatory damage than the caput. These regional differences in immunoregulation are further investigated using an experimental autoimmune epididymo-orchitis model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00441-020-03215-8DOI Listing

SARS-CoV-2 and the testis: similarity with other viruses and routes of infection.

Reprod Biomed Online 2020 06 17;40(6):763-764. Epub 2020 Apr 17.

Immunovirology Group, Department of Microbiology and Parasitology, Medical School, University of Antioquia, Antioquia, Colombia.

Since the start of the latest coronavirus (SARS-CoV-2) outbreak, the number of infected individuals and cases of coronavirus disease (COVID-19) has been increasing exponentially worldwide. Of interest is existing evidence that orchitis can develop due coronavirus infection. It is therefore not unreasonable to believe that SARS-CoV-2 could be transmitted by semen. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rbmo.2020.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162782PMC

Typhimurium Triggered Unilateral Epididymo-Orchitis and Splenomegaly in a Holstein Bull in Assiut, Egypt: A Case Report.

Pathogens 2020 Apr 24;9(4). Epub 2020 Apr 24.

Department of Anatomy, Embryology and Histology, Faculty of Veterinary Medicine, Assiut University, 71526 Assiut, Egypt.

This report illustrates, for the first time, a case of unilateral orchitis and epididymitis in a Holstein-Friesian bull, associated with infection ( serovar Typhimurium). A one and a half-year-old Holstein-Friesian bull had arrived at the Veterinary Hospital of Assiut University suffering from anorexia accompanied with persistent fever, which did not respond to oxytetracycline and flunixin meglumine injection for 15 days. Gross examination revealed left scrotal enlargement (three times its normal size), heat sensation, and induration of the testis and epididymis, which was painful on external palpation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/pathogens9040314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238186PMC

Sperm retrieval rates and clinical outcomes for patients with different causes of azoospermia who undergo microdissection testicular sperm extraction-intracytoplasmic sperm injection.

Asian J Androl 2020 Apr 21. Epub 2020 Apr 21.

Department of Urology, Peking University Third Hospital, Beijing 100191, China.

The aim of our study was to compare the sperm retrieval rates (SRRs) and clinical outcomes of patients with different causes of azoospermia who underwent microdissection testicular sperm extraction-intracytoplasmic sperm injection (micro-TESE-ICSI). We conducted a retrospective study at the Reproductive Medicine Center of Peking University Third Hospital in Beijing, China, from January 2014 to December 2017. This study examined 769 patients with nonobstructive azoospermia who underwent 347 cycles of micro-TESE-ICSI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aja.aja_12_20DOI Listing

A Curious Case of Blastomyces Osteomyelitis.

Cureus 2020 Mar 25;12(3):e7417. Epub 2020 Mar 25.

Family Medicine, Southern Illinois University School of Medicine, Springfield, USA.

Blastomycosis is an uncommon disease caused by the dimorphic fungus, Blastomyces dermatitidis, often found in endemic regions of Midwestern America. It can be found in forested, sandy soils, decaying vegetation, rotting wood near water sources, and even in bird feces. Most commonly, blastomycosis manifests as a pulmonary infection presenting as pneumonia, or in severe cases, respiratory distress syndrome (ARDS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182157PMC

Acute right epididymo-orchitis complicated by pampiniform plexus thrombosis.

Urol Case Rep 2020 Jul 3;31:101171. Epub 2020 Apr 3.

Department of Urology/nephrology, King Fahad Military Medical Complex, Dhahran, Eastern Province, Saudi Arabia.

Acute scrotum considered to be a common and one of the urological top emergency cases. However, acute testicular pain due to testicular vein thrombosis is rare especially if this thrombosis considered to be a complication of an infection, and not due to varicocele or malignancy-related conditions. A rare case of right epididymo-orchitis case complicated by right pampiniform plexus thrombosis, which resolved spontaneously with no anticoagulant management. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eucr.2020.101171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160564PMC

Testicular atrophy after mumps orchitis: ultrasonographic findings.

Ultrasonography 2020 Feb 29. Epub 2020 Feb 29.

Department of Radiology, Kyung Hee University Hospital, Seoul, Korea.

Purpose: The purpose of this study was to describe the ultrasonographic findings of testicular atrophy after mumps orchitis.

Methods: We retrospectively reviewed the case files of eight patients with mumps orchitis and testicular atrophy who were treated between January 2011 and September 2017. On gray-scale and color Doppler, the ultrasonographic features of volume, shape, echogenicity, and degree of blood flow in the testes were analyzed as part of both initial and follow-up ultrasonography. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14366/usg.19097DOI Listing
February 2020

Shear-wave elastography of the testicle: potential role of the stiffness value in various common testicular diseases.

Clin Radiol 2020 Apr 2. Epub 2020 Apr 2.

Department of Radiology B, University Hospital of Strasbourg - New Civil Hospital, 1, place de l' hôpital BP 426, Strasbourg, 67091, Cedex, France.

Aim: To assess the value and efficacy of real-time shear-wave elastography (SWE) of normal testicular parenchyma and various common testicular diseases in clinical practice.

Materials And Methods: SWE was undertaken in 338 patients (mean age: 43.2±17. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.crad.2020.02.016DOI Listing

[Testicular injection of lipopolysaccharide: An effective method for establishing the mouse model of orchitis].

Zhonghua Nan Ke Xue 2019 Aug;25(8):675-680

Faculty of Pathology, Nanchang University School of Medicine, Nanchang, Jiangxi 330006, China.

Objective: To search for a method of establishing a reliable mouse model of orchitis and investigate the association of orchitis with the activation of the inflammasome.

Methods: We equally randomized 40 adult male KM mice into groups A (sham operation), B (intraperitoneal injection of lipopolysaccharide [LPS]), C (unilateral testicular injection of glacial acetic acid [GAA]), and D (unilateral testicular injection of LPS). At 3 weeks after modeling, we measured the sperm concentration and percentage of progressively motile sperm (PMS) in the epididymis by computer-assisted semen analysis, observed the pathological changes in the testis tissue by HE staining, and determined the expressions of the Caspase-1 and interleukin (IL)-1β proteins by Western blot. Read More

View Article

Download full-text PDF

Source

Smooth muscle hyperplasia of the testicular adnexa: a clinicopathologic study of 12 cases.

Hum Pathol 2020 May 24;99:27-35. Epub 2020 Mar 24.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Smooth muscle hyperplasia of the testicular adnexa (SMH-TA) is a rare mass-forming intrascrotal lesion. Although benign, it can be a diagnostic challenge, as we have seen in our consult practice. Herein, we discuss our experience with these lesions over 14 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humpath.2020.03.003DOI Listing
May 2020
2.769 Impact Factor

Assessing the Utility of Ultrasound and Urinalysis for Patients with Possible Epididymo-Orchitis - A Retrospective Study.

Open Access Emerg Med 2020 13;12:47-51. Epub 2020 Mar 13.

Department of Emergency Medicine, Kendall Regional Medical Center, Miami, FL, USA.

Purpose: Many experts recommend ordering an ultrasound and a urinalysis on all patients with scrotal pain. While the ultrasound may help diagnose a number of potential causes of scrotal pain, the urinalysis primarily has value in assessing for epididymo-orchitis. This study sought to evaluate the utility of these diagnostic tests for patients who presented to the emergency department (ED) with acute scrotal pain and possible epididymo-orchitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/OAEM.S234413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081061PMC

Adrenal Failure and Orchitis Secondary to Tuberculosis Mimicking Metastatic Malignancy.

Am J Med 2020 Mar 19. Epub 2020 Mar 19.

Endocrine Unit, 1st Department of Propaedeutic Medicine, Laiko Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjmed.2020.02.019DOI Listing

Vascular wall injury and inflammation are key pathogenic mechanisms responsible for early testicular degeneration during acute besnoitiosis in bulls.

Parasit Vectors 2020 Mar 2;13(1):113. Epub 2020 Mar 2.

SALUVET, Animal Health Department, Faculty of Veterinary Sciences, Complutense University of Madrid, Ciudad Universitaria s/n, 28040, Madrid, Spain.

Background: Bovine besnoitiosis, caused by the apicomplexan parasite Besnoitia besnoiti, is a chronic and debilitating cattle disease that notably impairs fertility. Acutely infected bulls may develop respiratory signs and orchitis, and sterility has been reported in chronic infections. However, the pathogenesis of acute disease and its impact on reproductive function remain unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13071-020-3959-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053152PMC

Complete testicular infarction secondary to epididymoorchitis and pyocele.

Radiol Case Rep 2020 Apr 12;15(4):420-423. Epub 2020 Feb 12.

Donald and Barbara Zucker School of Medicine at Hofstra, Department of Radiology, Northwell at Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY, USA.

Epididymoorchitis is a relatively common urologic condition involving the scrotum which presents with unilateral pain and swelling. It is typically treated with antibiotics but can progress to complications such as scrotal pyocele. Global testicular infarction is an exceedingly rare but devastating complication of epididymoorchitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radcr.2020.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016336PMC

Ectopic Intravesical Ejaculatory Ducts: Case Report of Bulking Agent Injection for Treatment of Recurrent Epididymitis in a Patient With Anorectal Malformation.

Urology 2020 Jun 15;140:162-164. Epub 2020 Feb 15.

Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Urology Unit, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.

As far as we know this is the first report on bulking agent injection into intravesical ectopic ejaculatory orifices reported in the English literature. During a follow-up period of 23 months, the child was free of episodes of epididymo-orchitis. Deflux injection in this rare anomaly of intravesical refluxing ducts had prevented irreversible damage to the testes from recurrent EO. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urology.2020.02.003DOI Listing

Etiology and clinical features of epididymo-orchitis: A single-center study in Tehran, Iran.

Infect Disord Drug Targets 2020 Feb 17. Epub 2020 Feb 17.

Infectious diseases and tropical medicine research center, Shahid Beheshti University of Medical Sciences, Tehran.Iran.

Introduction: Epididymo-orchitis is a common urological disease among men. Little is known about the clinical and epidemiological aspects of the disease in Iran. Thus, the present study was aimed to investigate the etiology, clinical sequelae and risk factors of patients with epididymo-orchitis in Tehran, Iran. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1871526520666200218115400DOI Listing
February 2020

Tension-free mesh repair of inguinal hernia in patients on continuous ambulatory peritoneal dialysis.

Perit Dial Int 2020 01;40(1):62-66

Department of Surgery, Tung Wah Hospital, Sheung Wan, Hong Kong.

Background: Peritoneal dialysis (PD) is the first-line renal replacement therapy for end-stage renal failure patients in Hong Kong. Abdominal wall hernia is a common mechanical complication of PD, and early surgical repair has been advocated to reduce complications. This study aims to review the outcomes of tension-free mesh repair of inguinal hernia in PD patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0896860819879596DOI Listing
January 2020

A Review of the Diagnostic Use of Fine-needle Aspiration Cytology for Tuberculosis Epididymo-orchitis: To Do or Not to Do.

Cureus 2020 Jan 1;12(1):e6532. Epub 2020 Jan 1.

Family Medicine, Yuma Regional Medical Center, Yuma, USA.

Isolated tuberculous epididymo-orchitis is a rare manifestation of the vast extrapulmonary tuberculosis (EPTB) disease spectrum, especially in developed nations, making it prone to delayed diagnosis or misdiagnosis and inadvertent orchiectomy. Several observational studies and case reports have been reported with the successful use of fine-needle aspiration cytology (FNAC) in diagnosing tuberculosis orchitis, thus avoiding inadvertent orchiectomy. Because tuberculous epididymo-orchitis can mimic testicular neoplasm, the use of FNAC is not prevalent in developed countries for fear of the seeding of tumor cells and there is a lack of consensus on the use of FNAC for diagnostic purposes in such patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.6532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993070PMC
January 2020

Differential tissue-specific damage caused by bacterial epididymo-orchitis in the mouse.

Mol Hum Reprod 2020 Apr;26(4):215-227

Institute of Anatomy and Cell Biology, Justus-Liebig University of Giessen, Giessen 35385, Germany.

Ascending bacterial urinary tract infections can cause epididymo-orchitis. In the cauda epididymidis, this frequently leads to persistent tissue damage. Less coherent data is available concerning the functional consequences of epididymo-orchitis on testis and caput epididymidis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/molehr/gaaa011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187874PMC

Immunological microenvironment in the testis.

Reprod Med Biol 2020 Jan 29;19(1):24-31. Epub 2019 Aug 29.

Department of Anatomy Tokyo Medical University Tokyo Japan.

Background: The testis is specific in that it produces haploid germ cells of which autoantigens newly appear long after the neonatal immune tolerance. Under normal condition, these autoantigens are protected by the blood-testis barrier formed by Sertoli cells. Thus, the testis is an immunologically privileged site where haploid cells are protected from autoimmune attack. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/rmb2.12293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955586PMC
January 2020

Successful isolation of Treponema pallidum strains from patients' cryopreserved ulcer exudate using the rabbit model.

PLoS One 2020 13;15(1):e0227769. Epub 2020 Jan 13.

Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.

Clinical isolates of Treponema pallidum subspecies pallidum (T. pallidum) would facilitate study of prevalent strains. We describe the first successful rabbit propagation of T. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227769PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957173PMC
April 2020
3.234 Impact Factor

High index of suspicion for brucellosis in a highly cosmopolitan city in southern China.

BMC Infect Dis 2020 Jan 8;20(1):22. Epub 2020 Jan 8.

Department of Clinical Microbiology and Infection Control, The University of Hong Kong - Shenzhen Hospital, Shenzhen, China.

Background: Brucellosis is one of the most widespread zoonosis in the world. In China, 90% of human brucellosis occurs in six northern agricultural provinces. However, there is a recent increase in the trend of human brucellosis in southern provinces with limited cases reported in the literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-019-4748-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950854PMC
January 2020

Modified stepwise mini-incision microdissection testicular sperm extraction: a useful technique for patients with a history of orchidopexy affected by non-obstructive azoospermia.

J Zhejiang Univ Sci B 2020 Jan.;21(1):87-92

Department of Andrology, Center for Men's Health, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.

Non-obstructive azoospermia (NOA), which is defined as the absence of spermatozoa in the ejaculate secondary to impaired spermatogenesis within the testis, may be caused by a variety of etiologies, including varicocele-induced testicular damage, cryptorchidism, prior testicular torsion, post-pubertal mumps orchitis, gonadotoxic effects from medications, genetic abnormalities, chemotherapy/radiation, and other unknown causes currently classified as idiopathic (Cocuzza et al., 2013). The microdissection testicular sperm extraction (micro-TESE) technique involves a meticulous microsurgical exploration of the testicular parenchyma to identify and selectively extract larger seminiferous tubules that carry a higher probability of complete spermatogenesis (Schlegel, 1999). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1631/jzus.B1900232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964994PMC
January 2020

Randomized Controlled Trial Of Lichtenstein Repair Of Indirect Inguinal Hernias With Two Biologic Meshes From Porcine Small Intestine Submucosa.

Ther Clin Risk Manag 2019 31;15:1277-1282. Epub 2019 Oct 31.

Department of Hernia and Abdominal Wall Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, People's Republic of China.

Background: Biologic mesh is a newly developed material for hernia repairs which has been successfully used in clinical practices. This study aims to evaluate the clinical efficacy between patients undergoing a Lichtenstein's hernioplasty with a new biologic mesh derived from porcine small intestine submucosal (SIS) extracellular matrix versus a standard SIS mesh.

Methods: A prospective, randomized, double-blinded, multi-center trial was conducted in a 6-month study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/TCRM.S208185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827516PMC
October 2019

Predictive value of haematologic parameters in diagnosis of testicular torsion: Evidence from a systematic review and meta-analysis.

Andrologia 2020 Mar 28;52(2):e13490. Epub 2019 Nov 28.

Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.

To compare the difference of mean platelet volume (MPV), platelet lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), platelet (PLT) and leucocyte between testicular torsion (TT), epididymo-orchitis and healthy controls and further evaluate predictive values of these haematologic parameters in diagnosis and the differential diagnosis of TT. Databases were systematically retrieved, and reference search was also conducted manually. We applied Stata software 12. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/and.13490DOI Listing
March 2020
1.172 Impact Factor

[Clinical effect of the SCMC APL-2010 regimen in treatment of acute promyelocytic leukemia in children: an analysis of 44 cases].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Nov;21(11):1073-1078

Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

Objective: To study the clinical effect of the SCMC APL-2010 regimen in the treatment of acute promyelocytic leukemia (APL) in children.

Methods: A retrospective analysis was performed for the clinical data of 44 children with APL who received treatment with the SCMC APL-2010 regimen between April 2010 and July 2016. The Kaplan-Meier survival analysis was used to evaluate event-free survival (EFS) rate and overall survival (OS) rate. Read More

View Article

Download full-text PDF

Source
November 2019

Imaging of the acute scrotum: keys to a rapid diagnosis of acute scrotal disorders.

Abdom Radiol (NY) 2019 Nov 20. Epub 2019 Nov 20.

Section of Abdominal Imaging, Imaging Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.

Imaging of the scrotum in the setting of acute symptoms such as pain or swelling is commonly performed emergently to differentiate between patients who require immediate surgery and those that do not. Acute scrotal symptoms are generally caused by infectious, traumatic or vascular etiologies. Rapid diagnosis and initiation of treatment is vital for testicular salvage in cases of acute testicular torsion, testicular rupture, and Fournier gangrene. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00261-019-02333-4DOI Listing
November 2019

Acute epididymo-orchitis: relevance of local classification and partner's follow-up.

Cent European J Urol 2019 22;72(3):324-329. Epub 2019 Aug 22.

Department of Gynecology, O.O. Bogomolets National Medical University, Kyiv, Ukraine.

Introduction: Acute epididymo-orchitis (AEO) is a male urological emergency without an approved clinical classification. We aimed to determine the clinical value of proposed in 2012 local AEO classification system and summarize results of partner's follow-up.

Material And Methods: A total of 293 patients with AEO were enrolled into our study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5173/ceju.2019.1973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830488PMC

Fluoride Induces Autoimmune Orchitis Involved with Enhanced IL-17A Secretion in Mice Testis.

J Agric Food Chem 2019 Dec 18;67(48):13333-13343. Epub 2019 Nov 18.

Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, College of Animal Science and Veterinary Medicine , Shanxi Agricultural University , Taigu , Shanxi 030801 , China.

Fluoride (F) widely exists in the water and food. Recent studies reported that F induced testicular toxicity via inflammation reaction. This study was aimed to explore the mechanism of F-induced inflammation in testis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jafc.9b05789DOI Listing
December 2019
2.912 Impact Factor

Unusual intrascrotal lesions in adults in urological practice.

Arch Esp Urol 2019 Nov;72(9):955-964

Departamento de Urología. Hospital de la Universidad de Yüksek Ihtisas Koru Ankara. Ankara. Turquía.

Objective: Unusual intrascrotal lesions in adults generally have been described as case reports in the medical literature. We present two lesions observed in two clinics over more than 28 years, with their radiological, pathological and clinical characteristics.

Methods: Retrospective study preformed between 1989 and 2017 in 446 patients undergoing inguinal orchiectomy. Read More

View Article

Download full-text PDF

Source
November 2019

Xanthogranulomatous orchitis: Review of the published work, and report of one case.

Urol Case Rep 2019 Nov 7;27:100908. Epub 2019 May 7.

Sulaimanyah Teaching Hospital, 0046, Iraq.

Xanthogranulomatous reaction is rare begin disease affects many different organs, in clinical practice it is well known to affect kidney and gallbladder, but also affect male genital organs including (Testis, epididymis, and spermatic cord), we report a case 70-year old, diabetic patient presented with right scrotal swelling, had history of prior TURP, tumor markers was within normal range, ultrasound shows multiple hypo echoic lesions with moderate hydrocele, exploration done: pus found within tunica vaginalis, and destructed testicular tissue with necrosis, culture revealed (E.Coli), histopathology showed xanthogranulomatous orchitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eucr.2019.100908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819949PMC
November 2019

Testicular ischemia secondary to epididymo-orchitis: A case report.

Urol Case Rep 2019 Nov 19;27:100893. Epub 2019 Apr 19.

Urology Department, King Fahd Specialist Hospital, Buraidah, Saudi Arabia.

Testicular infarction is a common urological emergency in clinical practice, it is still underreported when it results from other than spermatic cord torsion. It rarely arises from other pathological processes like vasculitis and infectious disease. We report a case of 18-year-old with epididymo-orchitis complicated by testicular ischemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eucr.2019.100893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819811PMC
November 2019
1 Read

Role of indoleamine 2,3-dioxygenase in testicular immune-privilege.

Sci Rep 2019 11 4;9(1):15919. Epub 2019 Nov 4.

Universidad de Buenos Aires (UBA), Facultad de Medicina, Departamento de Biología Celular e Histología/Unidad Académica II., Ciudad Autónoma de Buenos Aires, C1121ABG, Argentina.

Male meiotic germ cell including the spermatozoa represent a great challenge to the immune system, as they appear long after the establishment of normal immune tolerance mechanisms. The capacity of the testes to tolerate autoantigenic germ cells as well as survival of allogeneic organ engrafted in the testicular interstitium have led to consider the testis an immunologically privileged site. Disruption of this immune privilege following trauma, tumor, or autoimmune orchitis often results in male infertility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-52192-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828782PMC
November 2019

More Than Just Torsion: An Unusual Case of Testicular Pain.

Mil Med 2019 Oct 28. Epub 2019 Oct 28.

Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708.

Testicular pain has a wide differential and the nonspecific presentation should be triaged rapidly for urgent diagnosis and treatment. Scrotal pyoceles are uncommon collections of purulent fluid between the visceral and parietal tunica vaginalis, usually secondary to acute epididymo-orchitis, intra-abdominal infection, or trauma. Epididymitis and epididymo-orchitis are generally secondary to sexually transmitted infections or urinary tract pathogens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/milmed/usz316DOI Listing
October 2019
2 Reads

Candida urinary tract infections in adults.

World J Urol 2019 Oct 25. Epub 2019 Oct 25.

Department of Infectious Diseases and Clinical Microbiology, Istanbul Medipol University, Istanbul, Turkey.

Candiduria is commonly seen in hospitalized patients and most of the patients are asymptomatic, but it may be due to cystitis, pyelonephritis, prostatitis, epididymo-orchitis or disseminated candidiasis. Major risk factors are diabetes mellitus, indwelling urinary catheters, use of broad-spectrum antibiotics, urinary obstruction, and admission to intensive care units. Candida urinary tract infections can be caused by hematogenous spread following candidemia, or retrograde route via the urethra. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00345-019-02991-5DOI Listing
October 2019

Japanese Encephalitis Virus infection induces inflammation of swine testis through RIG-I-NF-ĸB signaling pathway.

Vet Microbiol 2019 Nov 28;238:108430. Epub 2019 Sep 28.

State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, People's Republic of China; Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, People's Republic of China; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, Hubei 430070, People's Republic of China. Electronic address:

Japanese Encephalitis Virus (JEV) is an important zoonotic flavivirus transmitted by mosquitos. JEV infection in sows primarily manifests as a reproductive disease such as abortion and transient infertility while in infected boars, it can cause orchitis. Previous studies mainly focused on the pathogenesis of human encephalitis caused by JEV infection, while few concentrations have been made to unveil the potential mechanism of reproductive dysfunction in JEV-infected pigs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetmic.2019.108430DOI Listing
November 2019
2.511 Impact Factor

Disruption of the Dimer-Dimer Interaction of the Mumps Virus Attachment Protein Head Domain, Aided by an Anion Located at the Interface, Compromises Membrane Fusion Triggering.

J Virol 2020 01 6;94(2). Epub 2020 Jan 6.

Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Mumps virus (MuV), an enveloped negative-strand RNA virus belonging to the family , enters the host cell through membrane fusion mediated by two viral envelope proteins, an attachment protein hemagglutinin-neuraminidase (MuV-HN) and a fusion (F) protein. However, how the binding of MuV-HN to glycan receptors triggers membrane fusion is not well understood. The crystal structure of the MuV-HN head domain forms a tetramer (dimer of dimers) like other paramyxovirus attachment proteins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01732-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955283PMC
January 2020
1 Read

Epididymo-orchitis masquerading as an irreducible inguinal hernia.

Br J Hosp Med (Lond) 2019 Oct;80(10):616-617

Consultant Urologist, Nepean Urology Research Group, Department of Urology, Nepean Hospital, Sydney, New South Wales, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12968/hmed.2019.80.10.616DOI Listing
October 2019
1 Read