2,918 results match your criteria Orchitis
Sex Transm Dis 2018 Dec 3. Epub 2018 Dec 3.
Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle (WA) USA.
Treponema pallidum subsp. pallidum DNA and RNA were detected in a semen specimen of a syphilis patient with no genital or anal sores and no clinically evident orchitis. No nucleic acids were found in a urine sample of the same patient collected immediately before the semen sample. Read More
Schweiz Arch Tierheilkd 2018 Dec;160(12):743-748
Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Zurich.
Introduction: The following case report describes the clinical and diagnostic procedure for suspected brucellosis infection in a dog. A 21 month old intact male Border Collie was presented with an enlarged right testicle and epididymis. The dog was imported to Switzerland from Germany at the age of three months, but was never abroad since then. Read More
Sci Rep 2018 Dec 3;8(1):17531. Epub 2018 Dec 3.
Instituto de Biología y Medicina Experimental (IByME-CONICET), Buenos Aires, C1428ADN, Argentina.
Epididymal Cysteine Rich Secretory Proteins 1 and 4 (CRISP1 and CRISP4) associate with sperm during maturation and play different roles in fertilization. However, males lacking each of these molecules individually are fertile, suggesting compensatory mechanisms between these homologous proteins. Based on this, in the present work, we generated double CRISP1/CRISP4 knockout (DKO) mice and examined their reproductive phenotype. Read More
IDCases 2018 3;14:e00465. Epub 2018 Nov 3.
Department of Medicine, Division of Infectious Diseases, UT Health McGovern Medical School, Houston, TX, United States.
Bacillus Calmette-Guérin (BCG) therapy is a common adjunctive therapy for superficial bladder carcinoma but there has been noted to be complications from this treatment ranging from general disseminated infections to osteomuscular involvement. We report a case regarding a 63 year old gentleman who presented with right testicular swelling and pain and later found to have evidence consistent with orchitis. We also detail a literature review regarding genitourinary infections secondary to BCG therapy and discussion regarding current testing modalities. Read More
Basic Clin Androl 2018 16;28:14. Epub 2018 Nov 16.
Monmouth University, 400 Cedar Avenue, West Long Branch, NJ 07764 USA.
Background: Bacterial infection and inflammation of the testis impairs fertility, yet an understanding of inflammatory responses of the testis is incomplete. We are interested in identifying gene pathways involved in the detection and clearance of infectious microbes in the male reproductive tract. In previous studies in our lab focused on hypoxia-responsive genes of the testis, preliminary experiments suggested that genes classically categorized as hypoxia genes are also activated during antimicrobial responses. Read More
J Int Med Res 2018 Nov 19:300060518809778. Epub 2018 Nov 19.
Department of Urology, Tepecik Training and Research Hospital, Izmir, Turkey.
Objective: To investigate the use of hematological parameters in the differential diagnosis of testis torsion and epididymo-orchitis, and to determine the predictive value of these parameters in the diagnosis of testis torsion.
Methods: This study retrospectively reviewed the medical data of patients who presented to our institute with the complaint of acute scrotal pain. Eighty-five patients who had undergone orchiectomy or surgical detorsion due to testis torsion and 72 patients with epididymo-orchitis were included in the study. Read More
J Infect Public Health 2018 Nov 15. Epub 2018 Nov 15.
ICAR-National Research Centre on Meat, Chengicherla, Hyderabad, 500092, India.
Background: Swine brucellosis is a zoonotic disease caused by Brucella suis. The study describes the occurrence of brucellosis in two organized piggeries in Southern India.
Methods: A total of 585 serum samples comprising 575 from pigs and 10 from animal handlers were collected and tested by serological tests and PCR. Read More
J Paediatr Child Health 2018 Nov 8. Epub 2018 Nov 8.
Paediatric Surgery Department, Townsville Hospital, Townsville, Queensland, Australia.
Histol Histopathol 2018 Nov 7:18058. Epub 2018 Nov 7.
Institute for Anatomy, University of Veterinary Medicine Hannover, Hannover, Germany.
Impairment of blood-testis barrier integrity can be observed during inflammation, infection, trauma and experimental autoimmune orchitis, which is inducible in rodents. In the present study, an initially fertile two-year-old Beagle dog was presented with a decline in total sperm number resulting in azoospermia within five months, verified by twice-monthly semen analyses. The dog was clinically healthy with bilateral small testes and showed normal thyroid function. Read More
Trop Doct 2018 Nov 4:49475518809240. Epub 2018 Nov 4.
2 Junior Resident, Department of Surgery, UCMS and GTB Hospital, New Delhi, India.
Syphilis is notorious and a great imitator of all diseases. It is a chronic bacterial infection, caused by the sexually transmitted spirochete, Treponema pallidum. Though it has drastically reduced in prevalence, its recent resurgence (especially with HIV disease) is worrying. Read More
Nucl Med Mol Imaging 2018 Oct 2;52(5):377-379. Epub 2018 Jul 2.
1Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Sector -12, Chandigarh, 160012 India.
Testicular torsion is a common differential diagnosis of acute scrotal pain along with acute epididymo-orchitis, which may lead to testicular non-viability. Doppler ultrasound and testicular scintigraphy are two routinely used modalities for the assessment of testicular viability. However, in some cases, these investigations may prove inadequate in differentiating between the two entities with widely differing management. Read More
Indian J Pathol Microbiol 2018 Oct-Dec;61(4):600-603
Department of Pathology, IPGME and R, Kolkata, West Bengal, India.
Polyarteritis nodosa (PAN), a systemic necrotizing vasculitis with multiorgan development, is generally restricted to the medium-sized muscular arteries. The varied initial clinical presentations of PAN can lead to a delayed diagnosis. We present the case of a middle-aged male patient who presented with an acute onset right-sided testicular pain as the initial clinical symptom with ischemic changes on ultrasonogram, thereby requiring orchiectomy. Read More
JMM Case Rep 2018 Jul 5;5(7):e005157. Epub 2018 Jul 5.
Case Western Reserve, University School of Medicine, Cleveland, OH 44106, USA.
Introduction: Although more often recognized as a culprit in female urinary tract infection, coagulase-negative staphylococci (CoNS) can cause severe genitourinary infections in men. While positive blood cultures with CoNS are usually thought to be contaminants, in the setting of a severe genito-urinary infection they can represent true infection.
Case Presentation: We present the case of a 70-year-old male without a central venous catheter or urinary catheter who developed bloodstream infection secondary to epididymo-orchitis. Read More
Euro Surveill 2018 Sep;23(38)
Division for Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
From 6 September 2015-May 2016, a large mumps outbreak occurred among vaccinated students in Norway. A case was defined as a person presenting with a clinical mumps infection, notified between 1 September 2015 and 30 June 2016. Confirmed cases had positive laboratory confirmation and probable cases had an epidemiological link; PCR-positive specimens were genotyped. Read More
J Med Virol 2018 Sep 25. Epub 2018 Sep 25.
Department of Epidemiology, National Centre of Disease Control, Delhi, India.
Mumps, a vaccine-preventable disease, cause inflammation of salivary glands and may cause severe complications, such as encephalitis, meningitis, deafness, and orchitis/oophoritis. In India, mumps vaccine is not included in the universal immunization program and during 2009 to 2014, 72 outbreaks with greater than 1500 cases were reported. In August 2016, a suspected mumps outbreak was reported in Jaisalmer block, Rajasthan. Read More
BMJ Case Rep 2018 Sep 19;2018. Epub 2018 Sep 19.
Hull and East Yorkshire Hospitals NHS Trust, Hull, UK.
A retired businessman presented to the infectious diseases department with a history of ongoing fevers and myalgia and raised inflammatory markers. This continued despite adequate antibiotic treatment of an epididymo-orchitis. Extensive investigations, including bone marrow and liver biopsies and a positron emission tomography, did not reveal a cause but showed reactive change in the bone marrow. Read More
Zhonghua Nan Ke Xue 2018 08;24(8):681-685
Center of Reproduction, The Sixth Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510620, China.
Objective: To investigate the value of micro- dissection testicular sperm extraction (micro-TESE) in the treatment of non-obstructive azoospermia (NOA) in patients with the history of secondary testicular injury.
Methods: Totally, 121 NOA patients with the history of secondary testicular injury underwent micro-TESE in our hospital from September 2014 to December 2017. We analyzed the correlation of the sperm retrieval rate with the causes of testicular injury and compared the outcomes of the ICSI cycles with the sperm retrieved from the NOA males by micro-TESE (the micro-TESE group) and those with the sperm ejaculated from severe oligospermia patients (sperm concentration <1×10⁶/ml, the ejaculate group). Read More
Int J STD AIDS 2018 Aug 31:956462418793511. Epub 2018 Aug 31.
Sexual Health Department, the Great Western Hospital, Swindon, UK.
National guidelines recommend that male patients presenting with symptoms of urethritis or epididymo-orchitis undergo a urethral swab for microscopy. However, this is resource intensive. The aim of this audit was to determine the proportion of symptomatic patients without urethral discharge who have positive findings on urethral swab microscopy and explore associations between presenting symptoms and microscopy findings. Read More
Zhonghua Nan Ke Xue 2018 Janurary;24(1):82-85
Department of Reproductive Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
Male infertility is becoming a concern of the world. Studies show that testicular inflammation is closely related to male infertility, which often manifests itself in low sperm count and motility and even the loss of fertility. In recent years, testicular inflammation-induced male infertility is arousing more and more attention, which adds to the significance of its study. Read More
Urol Ann 2018 Jul-Sep;10(3):291-295
Department of Urology, Zagazig University, Zagazig, Egypt.
Aims: The aim of this study is to compare between transrectal ultrasound (TRUS)-guided aspiration and transurethral (TU) deroofing in the treatment of prostatic abscess regarding safety and efficacy.
Settings And Design: This prospective randomized study was done during the period between April 2009 and March 2015 and included 32 patients with prostatic abscess.
Subjects And Methods: All patients were enrolled in the study after obtaining a written informed consent and approval of the local ethical committee. Read More
Int J Environ Res Public Health 2018 07 31;15(8). Epub 2018 Jul 31.
Department of Infectious Diseases and Infection Control, Hospital of Ingolstadt, D-85049 Ingolstadt, Germany.
Vaccination against mumps virus (MuV) (mostly measles-mumps-rubella) is routinely performed in more than 120 countries and has resulted in a distinct decrease of mumps incidence. However, alteration of mumps epidemiology has been observed in several countries after implementation of the vaccine but is sparsely documented. Moreover, outbreaks have occurred after starting vaccination, even in highly vaccinated populations. Read More
Cureus 2018 May 29;10(5):e2703. Epub 2018 May 29.
Internal Medicine, Lahey Hospital and Medical Center, Burlington, USA.
Intravesical therapy with Bacillus Calmette-Guérin (BCG) is a common and effective therapy for bladder carcinoma in situ. The risks associated with intravesical BCG therapy are significant and rare. Accurate diagnosis and prompt initiation of management significantly reduce the morbidity associated with these risks. Read More
Vet World 2018 Jun 6;11(6):748-757. Epub 2018 Jun 6.
Department of Animal Medicine, Faculty of Veterinary Medicine, Aswan University, Egypt.
Background And Aim: Brucellosis is a major constraint to livestock production in Egypt as well as many developing countries worldwide. Bovine brucellosis is an economically important disease with reproductive failure as a principal manifestation resulting in abortion, premature birth and decreased milk production in females, and orchitis and epididymitis in males. In spite of the efforts of Egyptian veterinary services to overcome brucellosis, the disease is still prevalent in both animals and humans and represents one of the most important public health hazards in Egypt. Read More
Clin Exp Rheumatol 2018 Jun 19. Epub 2018 Jun 19.
Behçet's Disease Unit, Rheumatology Research Centre, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Objectives: This study proposed to report the characteristics of paediatric Behçet's disease (PED-BD) in a cohort of patients from Iran's registry and compare them with different reports throughout the world.
Methods: From a cohort of 7504 Iranian patients with Behçet's disease those diagnosed before the age of 16 years were included in this study. Data were collected on a standard protocol comprising 105 items, including demographic features, type of presentation, and different clinical and laboratory findings. Read More
Radiol Bras 2018 May-Jun;51(3):193-199
MD, PhD, Radiologist and Coordinator of the Imaging Department of the Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Emergencies involving the inguinal region and scrotum are common and can be caused by a plethora of different causes. In most cases, such conditions have nonspecific symptoms and are quite painful. Some inguinoscrotal conditions have high complication rates. Read More
Int J Mycobacteriol 2018 Apr-Jun;7(2):195-197
Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.
Hansen's disease is caused by Mycobacterium leprae. The disease is known to involve the visceral organs including the testis apart from the skin and nerves in the lepromatous pole of leprosy due to widespread hematogenous dissemination of lepra bacilli. Furthermore, there can be testicular pain during the type 2 reaction in Hansen's disease. Read More
Toxicol Lett 2018 Oct 6;295:134-143. Epub 2018 Jun 6.
Department of Immunology, Jinzhou Medical University, Jinzhou, Liaoning, China. Electronic address:
Increasing evidence shows that 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) enhances inflammation, and inflammation has a significant negative impact on fertility. Therefore, the aim of this study was to investigate the effects of TCDD on testis inflammation. Pregnant mice and primary Sertoli cells were treated with TCDD, and male offspring and Sertoli cells were treated with lipopolysaccharides(LPS). Read More
BMJ Case Rep 2018 Jun 4;2018. Epub 2018 Jun 4.
McGaw Medical Center of Northwestern University, Chicago, Illinois, USA.
Testicular toxoplasmosis is a very rare presentation of A 26-year-old immunocompetent man presented to us with right testicular pain and a right epididymal mass. Ultrasound was concerning for malignancy and a radical orchiectomy was performed. Surgical pathology revealed chronic granulomatous inflammation which stained positive for . Read More
BMJ Case Rep 2018 Jun 4;2018. Epub 2018 Jun 4.
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Testicular plasmacytomas are rare, accounting for only 1.3% of all extramedullary plasmacytomas. The infrequency in which it is encountered, coupled with its non-specific clinical and sonographic presentation, makes its diagnosis a challenge. Read More
Biomed Res Int 2018 22;2018:5712920. Epub 2018 Apr 22.
Department of Medical Engineering and Technology, Xinjiang Medical University, Urumqi, Xinjiang 830011, China.
. Brucellosis has a wide spectrum of clinical manifestations and it may last several days or even several years; however, it is often misdiagnosed and therefore may cause inadequate therapy and prolonged illness. Previous studies about meta-analysis of manifestations of brucellosis reported in English lacked the data published in Chinese, which did not provide details about the contact history, laboratory tests, and misdiagnosis. Read More
Vaccine 2018 06 18;36(26):3721-3726. Epub 2018 May 18.
Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:
Mumps, a common childhood disease in the pre-vaccine era that causes swelling of the parotid salivary glands, can lead to orchitis, viral meningitis, and sensorineural deafness. While the incidence of disease decreased dramatically after the vaccine was added to standard vaccination schedules, the disease has made a substantial resurgence in recent years. As a result, it becomes critical to examine the factors involved in recurring outbreaks. Read More
Reproduction 2018 07 9;156(1):35-46. Epub 2018 May 9.
Center for Molecular Carcinogenesis and ToxicologyDivision of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, Texas, USA
The testis is an organ that maintains an immune suppressive environment. We previously revealed that exposure of pre-pubertal rats to an acute dose of a well-described Sertoli cell toxicant, mono-(2-ethylhexyl) phthalate (MEHP), leads to an accumulation of CD11b+ immune cells in the testicular interstitial space that closely correlates with a robust incidence of germ cell (GC) apoptosis. Here, we test the hypothesis that the infiltrating immune cells contribute to GC apoptosis. Read More
Andrologia 2018 May 8:e13034. Epub 2018 May 8.
Instituto de Biología y Medicina Experimental, CONICET, Ciudad de Buenos Aires, Argentina.
Ageing is usually characterised by a mild chronic proinflammatory state. Despite the tight association between both processes, the phenomenon has recently been termed inflammageing. Inflammation in the male reproductive tract is frequently linked with bacterial or virus infections but also with a broad range of noninfectious processes. Read More
BMC Urol 2018 May 8;18(1):34. Epub 2018 May 8.
Department Of Urology, Apollo Hospitals, Mysore, Karnataka, India.
Background: Acute scrotal pain has various causes. Testicular torsion, torsion of appendages and Epididymo-orchitis are common causes, while varicocele thromboses are a rare cause. Varicocele thromboses can occur post operatively or spontaneously. Read More
Zhonghua Nan Ke Xue 2017 Sep;23(9):804-807
Center of Reproductive Medicine, The Sixth Hospital Affiliated to Sun Yat-sen University, Guangzhou, Guangdong 510620, China.
Objective: To investigate the effect of micro-dissection testicular sperm extraction (microTESE) for patients with non-obstructive azoospermia (NOA) and the indications of the strategy.
Methods: This retrospective study included 196 cases of NOA undergoing microTESE in our center from September 2014 to March 2017. We recorded the sperm retrieval rate (SRR) and analyzed its correlation with the patients' age, testis volume, level of blood follicle-stimulating hormone (FSH), and etiological factors. Read More
Int Braz J Urol 2018 Jul-Aug;44(4):771-778
Department of Urology, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey.
Objectives: Brucellosis is a multi-system infectious disease that is associated with inflammation, which causes an increase in acute phase reactants. Hematological inflammatory markers of brucellosis include mean platelet volume (MPV), red cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR). In this study, we aimed to evaluate the diagnostic value of hematological inflammatory markers in Brucella epididymo-orchitis (BEO), and to investigate the utility of these markers for differential diagnosis from non-Brucella epididymo-orchitis (non-BEO). Read More
Hinyokika Kiyo 2018 Feb;64(2):75-78
The Department of Urology, Yamagata Prefectural Central Hospital.
A 59-year-old man presented with pain and swelling of the right scrotum. Magnetic resonance imaging revealed a mass withsignal intensity similar to background on an apparent diffusion coefficient (ADC)-map of the upper region of the right testis. Inflammation was considered, but a testicular tumor could not be ruled out. Read More
Emerg Radiol 2018 Aug 21;25(4):341-348. Epub 2018 Apr 21.
Department of Radiologic Sciences, Wake Forest University Baptist Medical Center, Medical Center Blvd, Winston-Salem, NC, 27157, USA.
Scrotal pain is a common acute presentation for medical care. Testicular torsion and epididymo-orchitis are two diagnoses for which early detection is critical and their sonographic imaging features have been thoroughly described in the radiologic literature. Other important conditions for which radiologists must be aware have received less attention. Read More
Indian J Pediatr 2018 Nov 20;85(11):1035-1036. Epub 2018 Apr 20.
Department of Pediatric Medicine, Institute of Post-Graduate Medical Education and Research, 244 A.J.Bose Road, Kolkata, -700020, India.
BMJ Case Rep 2018 Apr 17;2018. Epub 2018 Apr 17.
Paediatric Surgery, John Hunter Children's Hospital, New Lambton, Australia.
The clinical differential diagnosis of scrotal pain with a mass in a prepubertal boy is difficult. Often conditions such as testicular torsion and epididymo-orchitis are diagnosed. We present a rare cause of scrotal pain, idiopathic scrotal fat necrosis. Read More
Comp Med 2018 Apr;68(2):168-176
Department of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut, USA; Department of Comparative Medicine, Mayo Clinic, Rochester, Minnesota, USA., Email:
Providing social housing for adult male macaques can be challenging. One successful strategy for long-term social housing of adult male macaques is to pair them with adult females; however, unwanted breeding must be prevented by sterilization of the male or female. Vasectomy is a simple, highly effective, and minimally invasive method of contraception that is used at our institution to facilitate social housing. Read More
Vaccine 2018 05 10;36(19):2589-2595. Epub 2018 Apr 10.
EPI Department, Beijing Center for Disease Control and Prevention, Beijing 100013, PR China.
Background: Since the introduction of mumps-containing vaccines (MuCV) in 1995 in Beijing, two-dose MuCV vaccination policy has been used, with the 1st and 2nd doses given at 18 months and 6 years of age, respectively.
Methods: Mumps epidemiology during 2005-2016 was described using surveillance data. Vaccine effectiveness (VE) of MuCV against disease was estimated for cases born during 2002-2009 and reported in 2016. Read More
Hum Reprod Update 2018 Jul;24(4):416-441
Institute of Anatomy and Cell Biology, Unit of Reproductive Biology, Aulweg 123, Giessen, Germany.
Background: Infection and inflammation of the reproductive tract are significant causes of male factor infertility. Ascending infections caused by sexually transmitted bacteria or urinary tract pathogens represent the most frequent aetiology of epididymo-orchitis, but viral, haematogenous dissemination is also a contributory factor. Limitations in adequate diagnosis and therapy reflect an obvious need for further understanding of human epididymal and testicular immunopathologies and their contribution to infertility. Read More
JAAPA 2018 May;31(5):19-22
Alanna M. Balbi is a medical student at the University of South Florida in Tampa, Fla. Amanda A. Van Sant practices in the ED at Lehigh Valley Health Network in Bethlehem, Pa. Eric W. Bean is an emergency medicine physician at Lehigh Valley Health Network. Jeanne L. Jacoby is assistant research director and an attending physician in the ED at Lehigh Valley Health Network and a clinical associate professor in the University of South Florida's Morsani College of Medicine. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Mumps is a systemic viral illness, preventable by vaccination, that typically affects children and is characterized by unilateral or bilateral swelling of the parotid glands. Uncommon complications such as orchitis, oophoritis, deafness, pancreatitis, aseptic meningitis, and encephalitis occur more often in adults. Recent outbreaks of the disease appear to be caused by a failure to maintain herd immunity in certain populations, particularly in affluent white communities. Read More
Urologe A 2018 May;57(5):594-600
Institut für Geschichte der Medizin, Robert Bosch Stiftung, Straußweg 17, 70184, Stuttgart, Deutschland.
Disorders of the lower abdomen were often associated with sexually transmitted diseases (STDs) or related conditions. The urological diagnostic workup and treatment was based on the idea that technical devices and objective scientific examination methods would lead to targeted success. The fact that illnesses such as urinary retention, urinary incontinence, urge incontinence, orchitis or urethritis often implicated psychosomatic complications and had a possibly far more important impact on sexual life did not play a role in the early years of urology. Read More
N Engl J Med 2018 03;378(13):1233-1240
From the Departments of Medicine (R.W.T.), Radiology (H.Y.), Urology (D.M.D.), and Pathology (D.P.S.), Massachusetts General Hospital, and the Departments of Medicine (R.W.T., R.M.H.), Radiology (H.Y.), Urology (D.M.D.), and Pathology (D.P.S.), Harvard Medical School - both in Boston.
J Pediatr Urol 2018 Jun 9;14(3):274.e1-274.e5. Epub 2018 Mar 9.
Division of Urology, Hospital for Sick Children and Department of Surgery, University of Toronto, Ontario, Canada. Electronic address:
Introduction: Cryopreservation of testicular tissue (TT) has become an increasingly attractive option for fertility preservation (FP), particularly for pre-pubertal boys at risk for gonadotoxicity from cancer therapy. At our institution, all at-risk families undergo counseling regarding infertility risk and available FP strategies, including this vulnerable patient population. As the technology required to use the acquired tissue is, as yet, unproven, it is paramount to document minimal morbidity and complications from this procedure. Read More
Dis Aquat Organ 2018 Mar;128(1):73-79
Laboratory of Wildlife Comparative Pathology, Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP 05508-270, Brazil.
We report the gross and microscopic findings and molecular identification of 2 cases of hyphate fungal infection in cetaceans from Brazil. The first case involved an adult male Atlantic spotted dolphin Stenella frontalis with localized pulmonary disease characterized by pyogranulomatous and necrotizing bronchopneumonia with intralesional hyphae. The second case involved an adult male Bryde's whale Balaenoptera edeni with orchitis, periorchitis, mesenteric lymphadenitis and pyogranulomatous bronchopneumonia with intralesional hyphae. Read More
JAMA Neurol 2018 Jun;75(6):746-750
Neuropathology Division, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Importance: Powassan virus is a rare but increasingly recognized cause of severe neurological disease.
Objective: To highlight the diagnostic challenges and neuropathological findings in a fatal case of Powassan encephalitis caused by deer tick virus (lineage II) in a patient with follicular lymphoma receiving rituximab, with nonspecific anti-GAD65 antibodies, who was initially seen with fever and orchiepididymitis.
Design, Setting, And Participants: Comparison of clinical, radiological, histological, and laboratory findings, including immunohistochemistry, real-time polymerase chain reaction, antibody detection, and unbiased sequencing assays, in a single case report (first seen in December 2016) at an academic medical center. Read More