3,286 results match your criteria Orchitis


Single intratesticular injection of blood-serum-derived exosomes can potentially alleviate testopathy following testicular torsion.

Animal Model Exp Med 2022 May 20. Epub 2022 May 20.

Department of Anatomical Sciences, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran.

Background: Testicular torsion (TT) is an acute inflammatory process leading to male infertility. Today, anti-inflammatory effects of exosomes derived from blood serum are used in various laboratory procedures. In the present study, the anti-inflammatory effects of blood-serum-derived exosomes in treatment of acute inflammation following TT in mice were evaluated. Read More

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Xanthogranulomatous orchitis: A rare case of testicular mass.

Urol Case Rep 2022 Jul 7;43:102111. Epub 2022 May 7.

Department of Urology, Ipswich Hospital, QLD, Australia.

Xanthogranulomatous orchitis is a rare non-malignant condition. This study reports a new case of xanthogranulomatous orchitis in a 77-year-old male, who presented with acute right scrotal mass. Ultrasound and computed tomography showed a heterogenous lesion involving the testis, with a loculated collection in the overlying scrotal wall. Read More

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The Brief Case: Brucella suis Infection in a Household of Dogs.

J Clin Microbiol 2022 May 18;60(5):e0098421. Epub 2022 May 18.

Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA.

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Closing the Brief Case: Brucella suis Infection in a Household of Dogs.

J Clin Microbiol 2022 May 18;60(5):e0098521. Epub 2022 May 18.

Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA.

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Immune homeostasis and disorder in the testis - Roles of Sertoli cells.

J Reprod Immunol 2022 Apr 15;152:103625. Epub 2022 Apr 15.

Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China. Electronic address:

The mammalian testis requires a highly organized microenvironment for the execution of its main functions, sperm production and testosterone synthesis. The testis possesses an immunoprivileged status essential for the protection of immunogenic male germ cells from detrimental immune responses. To counteract microbial infections, the tissue-specific cells are well equipped with innate defense machineries, termed pattern recognition receptors (PRRs), that can initiate innate immune responses. Read More

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Vasitis mimicking an inguinal hernia: A diagnostic dilemma.

Urol Case Rep 2022 Jul 25;43:102097. Epub 2022 Apr 25.

The Tweed Hospital, Tweed Heads, NSW, 2485, Australia.

Vasitis is a rare disorder characterised by inflammation of the vas deferens. It presents with scrotal or inguinal pain/swelling, mimicking the more commonly occurring conditions such as epididymitis, orchitis, testicular torsion or an incarcerated inguinal hernia. While ultrasound may exclude some of these differential diagnoses, computed tomography (CT) or Magnetic resonance imaging (MRI) is needed to distinguish vasitis from an incarcerated inguinal hernia. Read More

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Reprint of: A rare diagnosis of segmental testicular infarction on colored doppler ultrasound.

Dis Mon 2022 Apr 25:101383. Epub 2022 Apr 25.

Sacred Heart University Physician Assistant Studies, Fairfield, CT, United States.

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Segmental testicular infarct with an associated testicular artery aneurysm: Case report of a rare clinical entity.

Radiol Case Rep 2022 Jun 13;17(6):2150-2154. Epub 2022 Apr 13.

Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242-1077, USA.

Segmental testicular infarct is a rare clinical entity and can be a diagnostic challenge. Although cases are often idiopathic, underlying etiologies can include testicular torsion, epididymo-orchitis, trauma, vasculitis, and hypercoagulable states. Once suspected, an underlying testicular neoplasm should be excluded. Read More

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Pattern of Male Hypogonadism and Outcome of Treatment in South Rajasthan.

J Assoc Physicians India 2022 Apr;70(4):11-12

Pacific Medical College and Hospital, Udaipur.

Male reproductive functions are governed by hypothalamic pituitary testicular axis. If any component of this axis malfunctions, then hypogonadism will develop which is characterized by ill-defined secondary sexual features and low serum testosterone. The common patterns seen are primary and secondary testicular failure in the young; and late onset hypogonadism in the elderly. Read More

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A simplified ultrasound approach to diagnose testicular torsion and predict unsalvageable testis.

Med Ultrason 2022 Apr 18. Epub 2022 Apr 18.

Department of Radiology, Dongtan Sacred Heart Hospital, Hallym University Medical Center, 7, Keunjaebong-gil, Hwaseong-si, Gyeonggi-do 18450, Republic of Korea.

Aims: To develop a decision tree model using US features to differentiate testicular torsion and other conditions of acute scrotum and to investigate predictive parameters of unsalvageable testis in testicular torsion.

Materials And Methods: Scrotal US was reviewed in patients aged <30 years who presented with acute scrotum from 2014 to 2020. US findings of whirlpool sign, testicular volume ratio, heterogeneous echotexture, testicular vascularity, epididymis enlargement and/or hyperemia, and avascular nodule were evaluated and compared. Read More

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Chronic Immune-Mediated Orchitis Is the Major Cause of Acquired Non-obstructive Azoospermia in Dogs.

Front Vet Sci 2022 1;9:865967. Epub 2022 Apr 1.

Department of Veterinary Sciences, Section for Veterinary Reproduction and Obstetrics, Faculty of Health and Medical Sciences, University of Copenhagen, Tåstrup, Denmark.

Azoospermia, the lack of spermatozoa in the ejaculate, is the most common finding in infertile but otherwise healthy male dogs and represents an increasing reproductive health issue in men, too. The diagnosis can be further classified as non-obstructive azoospermia and obstructive azoospermia due to an obstruction of the deferent ducts. Although non-obstructive azoospermia comprises more than half of azoospermic cases in men and is a common cause of infertility in the male dog, knowledge of the underlying etiology and pathophysiology is still strongly limited, and much uncertainty exists about the true incidence and possible treatment options. Read More

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Characterization of lesions in the temporal muscle and the male reproductive system (epididymis and testicle) of dogs experimentally infected with Leishmania infantum with different clinical stages.

Vet Parasitol 2022 Mar 26;305:109700. Epub 2022 Mar 26.

Animal Pathology Department, Faculty of Veterinary Sciences, Agrifood Institute of Aragón (IA2), University of Zaragoza-CITA, Zaragoza, Spain.

Leishmaniosis is a zoonotic disease with a very complex pathogenesis modulated by the interaction between the parasite, the vector and the host. Although the pathological characteristics have been extensively studied in the typically affected organs, some locations such as muscles and reproductive organs have been less studied. The objective of this study was to evaluate the presence of lesions in the temporal muscle and the male reproductive organs (testicle and epididymis) and correlate their characteristics with the presence of the parasite and with the clinical status of the dogs. Read More

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Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine, and Endocrine Dysregulation.

Pathophysiology 2021 Oct 15;28(4):471-488. Epub 2021 Oct 15.

Laboratory of the Mosaics of Autoimmunity, Saint Petersburg State University, 199304 Saint Petersburg, Russia.

According to global data, there is a male reproductive potential decrease. Pathogenesis of male infertility is often associated with autoimmunity towards sperm antigens essential for fertilization. Antisperm autoantibodies (ASAs) have immobilizing and cytotoxic properties, impairing spermatogenesis, causing sperm agglutination, altering spermatozoa motility and acrosomal reaction, and thus preventing ovum fertilization. Read More

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October 2021

Persistence and shedding of senecavirus A in naturally infected boars.

J Vet Diagn Invest 2022 May 31;34(3):474-481. Epub 2022 Mar 31.

Veterinary Diagnostic Laboratory.

Senecavirus A (SVA) infection in pigs causes vesicular disease and results in a short viremia and transient shedding of the virus, mainly in oral fluids and feces. Here we describe the consistent prolonged shedding of SVA in the semen of 2 boars, and persistence of SVA within the tonsils and testes of 3 adult boars. Two SVA-infected boars that were identified on a Minnesota sow farm in 2017 shed SVA RNA in semen for >3 mo after an outbreak of vesicular disease had occurred on the farm. Read More

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Torsion of the spermatic cord in adults: a multicenter experience in adults with surgical exploration for acute scrotal pain with suspected testicular torsion.

Asian J Androl 2022 Mar 22. Epub 2022 Mar 22.

Department of Urology, Rennes University Hospital, Rennes 35000, France.

Acute scrotal pain (ASP) requiring surgical exploration is common in the pediatric population, but little has been reported on this subject with regard to the adult population. The aim of this study was to investigate the demographic and clinical characteristics and outcomes of scrotal explorations performed on adult patients. Patients over 21 years of age who underwent surgical exploration for ASP with suspected testicular torsion (TT) at 14 French hospitals between January 2005 and December 2019 were included in this study. Read More

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COVID-19 and the Endocrine System: A Review of the Current Information and Misinformation.

Infect Dis Rep 2022 Mar 11;14(2):184-197. Epub 2022 Mar 11.

Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87106, USA.

Coronavirus disease 2019 (COVID-19) infection primarily involves the respiratory system but has many noteworthy extra pulmonary manifestations as well. We write this review to highlight the basis of some pathophysiological mechanisms of COVID-19 infection-induced endocrine dysfunction. Different scientific databases and institutional websites were searched to collect and consolidate the most up-to-date data relating to COVID-19 infection and endocrine systems. Read More

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A Review of Recent Studies on the Effects of SARS-CoV-2 Infection and SARS-CoV-2 Vaccines on Male Reproductive Health.

Med Sci Monit 2022 Mar 21;28:e935879. Epub 2022 Mar 21.

Moscow Institute of Physics and Technology (National Research University), Dolgoprudnyj, Moscow region, Russian Federation.

According to world statistics, men are more susceptible to the coronavirus disease 2019 (COVID-19) than are women. Considering the interconnection between infections and male infertility, investigation of the potential impact of COVID-19 on men's reproductive health is now a particularly relevant topic. Published data indicate decreased sperm quality and orchitis development in patients with COVID-19, including reduced sperm count, decreased sperm motility, and elevated DNA fragmentation index. Read More

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Mumps Infection With Symptoms of Parotitis, Pancreatitis, and Orchitis Concurrently in an Adolescent Male.

Cureus 2022 Feb 6;14(2):e21963. Epub 2022 Feb 6.

Internal Medicine, Government Medical College and Hospital, Chandigarh, IND.

Mumps is a highly contagious childhood infectious disease caused by the mumps virus. Clinical symptoms of mumps infection among vaccinated young adults are rarely seen. We present an unusual case of a vaccinated young male who presented with a clinical picture suggestive of mumps infection with symptoms of parotitis, pancreatitis, and orchitis. Read More

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February 2022

Emphysematous epididymo-orchitis: imaging plays a vital part in active management: case report and literature review.

J Surg Case Rep 2022 Mar 9;2022(3):rjac060. Epub 2022 Mar 9.

Urology Department, Whittington Hospital, London N19 5NF, United Kingdom.

We hereby present a rare cause of acute scrotum secondary to (EEO). It is often not diagnosed until crepitus is palpable in the scrotal wall with spreading cellulitis, at which point it has reached an advanced stage. This case report details a 55-year-old man with poorly controlled diabetes who presented with an acute scrotum that failed to resolve with oral antibiotics in primary care. Read More

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[Practice of urological departments during the COVID-19 pandemic].

Urologiia 2022 Mar(1):35-40

TB Research Institute of Ministry of Health of Russia, Novosibirsk, Russia.

Introduction: The pandemic of novel coronavirus infection has had a strong impact on the whole medical system, including urological departments.

Material And Methods: We assessed the impact of restrictions due to the pandemic on the work of urological departments of private (Medical Center "Avicenna", Novosibirsk) and community (KGBUZ "City Clinical Hospital No. 11, Barnaul") hospitals; GBUZ of the Novosibirsk region "City Clinical Emergency Hospital" (GBUZ CCEH) No. Read More

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Does SARS-CoV-2 affect male urogenital system?

Curr Pharm Biotechnol 2022 Mar 7. Epub 2022 Mar 7.

Department of Gynecology and Obstetrics with Gynecologic Oncology, Ludwik Rydygier Memorial Specialized Hospital, Kraków, Poland | Department of Histology, Cytophysiology and Embryology, Faculty of Medicine, University of Technology in Katowice, Zabrze, Poland.

Background: Widely known fact about Sars-Cov-2 infection's impact on urogenital system may play relevant role in under-standing, diagnose and future prevention of male urological disorders. Sars-CoV-2 attacks vascular endothelium of the entire organism therefore infection complications are visible in various organs. Relatively small number of original studies on Sars-cov-2 infection and the effect on the reproductive system and fertility in men. Read More

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Testicular infarction and spontaneous scrotal rupture secondary to acute epididymo-orchitis.

BMJ Case Rep 2022 Mar 4;15(3). Epub 2022 Mar 4.

Department of Urology, Northern Hospital Epping, Epping, Victoria, Australia.

Epididymo-orchitis is a common cause of acute unilateral testicular pain. Both infectious or non-infectious causes have been proposed and, rarely, testicular abscess formation and even infarction can occur as a severe complication. We present here a case of acute epididymo-orchitis leading to testicular abscess formation, infarction and spontaneous rupture through the scrotal wall despite appropriate antibiotic treatments. Read More

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Ethnomedical, phytochemical and pharmacological insights on an Indian medicinal plant: The balloon vine (Cardiospermum halicacabum Linn.).

J Ethnopharmacol 2022 Jun 25;291:115143. Epub 2022 Feb 25.

Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India. Electronic address:

Ethnopharmacological Relevance: Cardiospermum halicacabum Linn. (C. halicacabum) is one of the well-known leafy green vegetables in India. Read More

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Xanthogranulomatous epididymo-orchitis: A case report with review of the literature.

Int J Surg Case Rep 2022 Mar 12;92:106832. Epub 2022 Feb 12.

Kscien Organization, Hamdi Str, Azadi Mall, Sulaimani, Kurdistan, Iraq.

Introduction: Xanthogranulomatous orchitis is an extremely rare condition of the test is marked by the necrosis and effacement of testicular parenchyma by an inflammatory process. The current study aims to report a case of xanthogranulomatous epididymo-orchitis.

Case Report: A 35-year-old man presented with a history of recurrent attacks of dull pain and swelling of the right side of the scrotum for 3 weeks. Read More

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Acute orchiepididymitis: Epidemiological and clinical aspects: An analysis of 152 cases.

Ann Med Surg (Lond) 2022 Mar 9;75:103335. Epub 2022 Feb 9.

Urology Department, IBN Rochd University Hospital, Casablanca, Morocco.

Introduction: Orchiepididymitis is an inflammation of the testis and epididymis. Epididymitis, orchitis, and true orchiepididymitis are all examples of orchiepididymites. They are the most frequent cause of adult acute scrotal pain. Read More

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Testicular Atrophy and Epididymitis-Orchitis Associated with Infectious Bronchitis Virus in Broiler Breeder Roosters.

Avian Dis 2022 Jan 20. Epub 2022 Jan 20.

Veterinary Diagnostic Pathology, LLC, Fort Valley, VA 22652.

Infectious bronchitis is a respiratory disease of chickens caused by a gammacoronavirus named infectious bronchitis virus (IBV). In addition to affecting the respiratory tract, IBV may also induce urogenital infections, leading to nephropathogenic disease, false layer syndrome in laying hens, and epididymal lithiasis and epididymitis in males. Here, we report a case of decreased reproductive efficiency due to male infertility in 33- to 38-wk-old broiler breeders. Read More

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January 2022

Clinical Evidence and Risk Factors for Reproductive Disorders Caused by Bacterial Infections in Meat Goats in Northeastern Thailand.

Vet Med Int 2022 8;2022:1877317. Epub 2022 Feb 8.

Department of Veterinary Bioscience and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand.

The objective of this study was to identify risk factors related to reproductive disorders caused by bacterial infections in goats in northeastern Thailand. Two hundred twenty farms were investigated, and 49 herds were found to have clinical reproductive disorders. Moreover, 96% (47/49) of herds showing clinical reproductive failure preferred to circulate bucks between herds. Read More

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February 2022

[Orchiectomy due to early syphilis].

Urologe A 2022 Feb 15. Epub 2022 Feb 15.

Abteilung für Dermatologie und Venerologie, Medizinische Universität Graz, Auenbruggerplatz 8, 8010, Graz, Österreich.

Granulomatous and abscessing testicular inflammations are important differential diagnoses of testicular tumors. Infectious orchitis should always be considered in unclear testicular masses with negative tumor markers. We report the case of a 45-year-old man with abscessing orchitis due to early syphilis diagnosed after orchiectomy with the suspicion of a seminoma. Read More

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February 2022

NLRP3 inflammasome is involved in testicular inflammation induced by lipopolysaccharide in mice.

Am J Reprod Immunol 2022 04 16;87(4):e13527. Epub 2022 Feb 16.

Laboratory of Animal Reproduction, Department of Agriculture, Tokyo University of Agriculture, Atsugi, Kanagawa, Japan.

Problem: Systemic inflammation induced by infection, which is associated with testicular inflammation, predisposes males to subfertility. Recently, the nucleotide-binding oligomerization domain, leucine-rich repeat-, and pyrin domain-containing 3 (NLRP3) inflammasome was identified as a key mediator of inflammation, and excessive activation of the NLRP3 inflammasome was shown to contribute to the pathogenesis of a wide variety of diseases. However, the mechanisms underlying infectious inflammation in the testis remain unclear. Read More

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How useful is a complete urinary tract ultrasound in orchiepididymitis?

PLoS One 2022 10;17(2):e0263934. Epub 2022 Feb 10.

Pediatric Emergency Division, Department of Pediatrics, Gynecology, and Obstetrics, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.

Orchiepididymitis (OE) is a frequent cause of pediatric emergency department attendance in boys presenting with acute scrotum. The etiology of most episodes of OE remains unclear and there is no consensus regarding the correlation between OE and underlying genitourinary malformations. Whether imaging evaluation should comprise complete urinary tract ultrasonography (US) or voiding cystography is a subject of debate. Read More

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February 2022