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Mol Clin Oncol 2019 Mar 18;10(3):343-351. Epub 2018 Dec 18.

Department of Urology and Andrology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.

The aim of the present study was to assess the oncological and functional outcomes of testis-sparing surgery (TSS) for testicular tumors compared with radical orchiectomy (RO) in a single center. A retrospective comparative cohort study was conducted in Changzheng Hospital. Patients were identified using the hospital information system from January 1999 to December 2016, collecting all of the data regarding clinical, treatment and prognostic profiles. Read More

J Urol 2019 03;201(3):444-445

Arch Esp Urol 2019 Jan;72(1):85-88

Servicio de Urología. Hospital General Universitario de Valencia. Valencia. España.

Objective: Paratesticular mesothelioma isan infrequent tumor and only 250 cases have been published.It originates in the scrotal tunica vaginalis. It represents0. Read More

J Surg Case Rep 2019 Jan 24;2019(1):rjy361. Epub 2019 Jan 24.

Department of Histopathology, PathLinks, Lincoln County Hospital, Greetwell Road, Lincoln, Lincolnshire, UK.

Benign multicystic mesothelioma is an extremely rare neoplasm usually arising from the visceral mesothelium of the peritoneal cavity typically presenting in young to middle-aged women. It has been deemed an indolent tumour with a possible heritable nature, but also a possible reactive neoplasm secondary to trauma. Diagnosis relies on identifying characteristic histology of cysts separated by loose connective tissue stroma and lined by pale, flat or cuboidal mesothelial cells. Read More

Asian J Androl 2019 Mar-Apr;21(2):196-200

Department of Urology, Peking University First Hospital, Beijing 100034, China.

The clinical predictive factors for malignant testicular histology remain unclear because of the low prevalence. Therefore, the aim of this study was to investigate predictors of malignant histology for testicular masses and decide more testis-sparing surgeries before surgery. This retrospective study enrolled 325 consecutive testicular mass patients who underwent radical orchiectomy (310/325) or testicular preserving surgery (15/325) from January 2001 to June 2016. Read More

Urology 2019 Jan 2. Epub 2019 Jan 2.

Children's Hospital Wisconsin and Medical College of Wisconsin Milwaukee, WI.

Extrarenal Wilms tumor is rare. We describe the first reported case of primary paratesticular extrarenal Wilms tumor with regional metastasis in 8-month old male with left undescended testis. Patient underwent left radical orchiectomy with regional lymph node excision. Read More

Urology 2019 Mar 28;125:8-19. Epub 2018 Dec 28.

Division of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, Canada.

Germ cell testicular tumors are the most commonly diagnosed cancer in young men, with cure rates exceeding 95%. Clinical stage 1 disease is the most common manifestation, with radical orchiectomy curing the majority of Clinical stage 1 patients, making active surveillance the treatment of choice, with a cancer specific survival nearing 100% and low relapse rates. However, in metastatic disease, chemotherapy, radiotherapy, and surgery are curative options. Read More

J Med Case Rep 2018 Dec 19;12(1):373. Epub 2018 Dec 19.

Department of Oncology, McMaster University, Juravinski Cancer Centre, 699 Concession St, Hamilton, ON, L8V 5C2, Canada.

Background: Over the last 40 years, there has been a significant increase in the incidence of testicular cancer. The epidemiologic evidence to understand this phenomenon is unclear, however exogenous estrogen exposure is thought to be a driver in the development of testicular cancer. This is of particular importance in the transgender population because utilization of exogenous estrogen therapy is an essential aspect of the transition process. Read More

J Cancer Res Ther 2018 Dec;14(Supplement):S1241-S1243

Department of Urology, Faculty of Medicine, Kemerburgaz University, Medical Park Bursa Hospital, Bursa, Turkey.

Paratesticular rhabdomyosarcoma (RMS) is a rare nongerm cell intrascrotal malignant tumor in children and young adult/teens resulting from the mesenchymal tissues of the tunica vaginalis, epididymis, spermatic cord, and testis. RMS accounts for approximately 7% of all genitourinary tract RMSs and 12% of all pediatric scrotal neoplasms. Patients usually present with a painless unilateral scrotal mass. Read More

Case Rep Oncol Med 2018 8;2018:8065615. Epub 2018 Nov 8.

Centro Universitario Contra el Cáncer, University Hospital "Dr. José Eleuterio González" and Faculty of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.

Choriocarcinoma syndrome (CS) is a rare clinical entity within the spectrum of nonseminomatous germ-cell tumors (NSGCT). It is characterized by the abrupt establishment of rapidly progressive and hemorrhagic tumors associated with very high levels of the beta fraction of human chorionic gonadotropin (-hCG) and with a very poor prognosis, particularly in patients with -hCG values above 50,000 IU/L. We present the case of a 17-year-old man with a sudden onset nonmassive hemoptysis. Read More

J Pediatr Urol 2019 Feb 23;15(1):70.e1-70.e6. Epub 2018 Oct 23.

Division of Pediatric Urology, Children's Hospital Colorado and Division of Urology, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address:

Introduction: In children, most small testicular tumors are benign, and testicular-sparing surgery (TSS) is a viable treatment option.

Objective: The objective of this study is to assess for correlation between the tumor size and final pathologic diagnoses appropriate for TSS for pediatric and adolescent patients with an intratesticular mass and negative serum tumor markers (STMs).

Materials And Methods: A retrospective review of 24 patients (aged 0-18 years) who underwent radical or partial orchiectomy between 2003 and 2015. Read More

Arch Esp Urol 2018 Nov;71(9):805

Hospital Universitario de Fuenlabrada. Madrid. España.

Urol J 2018 Nov 3. Epub 2018 Nov 3.

Shahid Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, 9th Boostan, Pasdaran avenue, Tehran, Iran.

Purpose: to evaluate the feasibility of cytoreductive radical prostatectomy (RP), lymphadenectomy, and bilateral orchiectomy in patients with advanced prostate cancer (PCa) with oligo- and poly-metastases. Furthermore, the functional and oncological outcomes of these patients in comparison with the control group that underwent treatment only with systemic therapy (ST group) is investigated in a well-selected, prospective cohort study.   Material and methods: A total of 26 patients were enrolled in CRP (cytoreductive radical prostatectomy) group and 23 patients in ST group. Read More

BMJ Case Rep 2018 Nov 1;2018. Epub 2018 Nov 1.

Urology Department, Centro Hospitalar do Porto, Porto, Portugal.

Adult granulosa cell tumours are extremely rare and usually benign but sometimes can assume an aggressive behaviour. A 31-year-old man presented with a 45 mm testicular mass. Radical orchiectomy was performed. Read More

Urology 2019 Feb 28;124:276-281. Epub 2018 Oct 28.

James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD.

Objective: To better understand patient decision-making and genital satisfaction associated with postorchiectomy testicular prosthesis (TP) implantation in patients with germ cell tumors of the testicle.

Materials And Methods: An electronic survey to assess TP decision-making and genital satisfaction was distributed to patients via an institutional database (n = 70) and social media outlets (n = 167). Statistical analyses were performed using chi-square tests for categorical variables, Wilcoxon-Mann-Whitney tests for continuous variables, and multivariate regression analyses to identify independent predictors of receiving a prosthesis, genital satisfaction, and prosthesis satisfaction. Read More

Diagn Cytopathol 2019 Feb 30;47(2):130-133. Epub 2018 Oct 30.

Department of Pathology, School of Medicine, University of Yamanashi, Yamanashi, Japan.

IgG4-related disease (IgG4-RD) can affect various organs, and the pancreas and salivary gland are representative examples. We report a rare case of IgG4-RD of the paratestis. A 74-year-old man presented with left scrotal swelling. Read More

Support Care Cancer 2019 Feb 22;27(2):373-382. Epub 2018 Oct 22.

Eastern Health Cancer Services, Level 4, 8 Arnold St., Box Hill, VIC, 3128, Australia.

Purpose: Testicular seminomas occur in young men and are highly curable. Toxicities following treatment for men with extensive stage II-III seminomas may cause long-term morbidities. However, it is not clear whether the risk of late effects also increases following surgery for testis-confined seminoma. Read More

Isr Med Assoc J 2018 Oct;20(10):642-644

Department of Urology, Kaplan Medical Center, Rehovot, Israel.

Background: Almost 50% of patients with germ-cell tumors (GCT) are subfertile, and every step of the treatment may further impair fertility. As a result, sperm banking is often advised prior to radical orchiectomy. However, whether affected testes contribute to fertility is unclear. Read More

Pediatr Surg Int 2018 Dec 15;34(12):1339-1343. Epub 2018 Oct 15.

Department of Pediatric Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

Aim: Prepubertal testicular tumors are rare in children. We aim to present clinical and histological features of prepubertal testicular tumors through the analysis of the long-term experiences of a single medical center of China.

Materials And Methods: A total of 67 children (≤ 14 years) treated for testicular tumor at our institution from 2005 to 2015 were retrospectively reviewed. Read More

Medicine (Baltimore) 2018 Oct;97(40):e12728

Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Rationale: Testicular metastases from renal cell carcinoma (RCC) are extremely rare. To the best of our knowledge, only 35 cases have been described in the literatures.

Patient Concerns: A 64-year-old male presented to our urology clinic for a palpable painless mass on his right side of the scrotum by self-examination 1 week ago, with a general abdominal ultrasonographic report showing a mass in his right kidney. Read More

J Res Med Sci 2018 26;23:64. Epub 2018 Jul 26.

Department of Urology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey.

Background: The purpose of this study was to assess the diagnostic role of preoperative hematological parameters, especially neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in germ cell testicular malignancies and their prediagnostic role in staging of testicular cancer.

Materials And Methods: In this cross-sectional retrospective study, we analyzed 39 patients who underwent radical orchiectomy due to a testicular cancer (Group 1) and 82 patients on whom varicocelectomy procedure was performed as control group (Group 2) between January 2006 and January 2016 in our clinic. Evaluation of the preoperative hematological parameters in both groups and also the subgroups in malignancy group according to histopathological stages was conducted in this study. Read More

Can Urol Assoc J 2018 08 30. Epub 2018 Aug 30.

Koc University, School of Medicine, Department of Urology, Istanbul.

Introduction: We present oncological and functional outcomes of patients who underwent testis-sparing surgery (TSS).

Methods: Overall, 13 patients were included. Mean patient age was 29. Read More

J Pediatr Hematol Oncol 2018 Aug 14. Epub 2018 Aug 14.

Department of Pediatric Surgery, "G.d'Annunzio" University of Chieti.

Background: Paratesticular fibrous pseudotumor (PFP) is a rare benign tumor that can mimic malignant tumors; thus, radical orchiectomy was the standard treatment in the past.

Observation: A 15-year-old boy came to our attention for a hard right inguinal swelling. An ultrasound showed a highly vascularized mass. Read More

Int J Surg Case Rep 2018 27;49:247-250. Epub 2018 Jun 27.

Department of Pediatric and Adolescent Surgery, General Hospital, Klagenfurt, Austria. Electronic address:

Introduction: Testicular neoplasms that are derived from connective tissue, blood vessels and musculature are uncommon and intra-testicular tumors of vascular origin are extremely rare; both are benign in nature. Testicular hemangioma is exceedingly rare and typically occurs in patients younger than 20 years, the age in which a primary germ cell tumor of the testis may present, necessitating a radical approach to management with orchidectomy, although potential conservative focal partial surgical excision is desirable. Hemangiomas of the testis have a similar sonographic and magnetic resonance imaging appearance to that of malignant tumors of the testis, especially seminoma. Read More

Urologia 2018 May 26;85(2):44-45. Epub 2018 Mar 26.

Department of Urology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.

Primary testicular osteosarcoma is an extremely rare type of malignant tumor, and to our knowledge, only two other cases have previously been reported in the medical literature. A 63-year-old man, who presented with a large painless left inguinal and scrotal mass, underwent radical orchiectomy. Pathological examination was suggestive of testiscular osteosarcoma. Read More

Arch Esp Urol 2018 Jul;71(6):549-554

Servicio de Urología. Complejo Asistencial de Avila. Avila. España.

Objective: We report two cases of patients diagnosed of paratesticular liposarcoma and perform a literature review of this rare entity. Our aim is to clarify its clinical and therapeutic characteristics.

Methods: Retrospective review of the medical records of two patients diagnosed of liposarcoma of the spermatic cord. Read More

Am J Surg Pathol 2018 Oct;42(10):1286-1296

Department of Pathology, Johns Hopkins Medical Institute, Baltimore, MD.

Prostatic adenocarcinoma with focal pleomorphic giant cell features is rare with the only prior series consisting of 6 cases. From 2005 to 2018, we identified 29 cases from our consult service and 1 case from our own institution. Men ranged in age from 39 to 90 years (median=75. Read More

Medicine (Baltimore) 2018 06;97(25):e11164

Department of Urology, The First Hospital of Quanzhou Affiliated to Fujian Medical University.

Rationale: Most patients with paratesticular rhabdomyosarcoma may typically present as a unilateral, painless palpable scrotum mass. However, only a few cases of RMS presenting as painful edema of the scrotum mimicing epididymitis. We herein report an unusual case of alveolar paratesticular rhabdomyosarcoma misdiagnosed as epididymitis. Read More

Medicine (Baltimore) 2018 Jun;97(25):e11158

Department of Radiology, the Second Affiliated Hospital of Nanjing Medical University.

Rationale: Testicular Leydig cell tumor (LCT) is a rare neoplasm. It commonly presents as a painless testicular mass with or without endocrine changes. Histological and immunohistochemical examination play important roles in differentiating LCT from testicular germ cell tumors. Read More

Int J Health Sci (Qassim) 2018 May-Jun;12(3):94-95

Department of Physiology, Gonabad University of Medical Sciences, Gonabad, Iran.

It is commonly accepted to consider retroperitoneal germ cell tumors as the metastasis of a viable or burned-out testicular tumor. In such cases, orchiectomy should be performed since the burned-out site in the testis could continue to harbor malignancy despite systemic chemotherapy. A 45-year-old male presented as an outpatient with complaints of back pain. Read More

BMJ Case Rep 2018 Jun 4;2018. Epub 2018 Jun 4.

McGaw Medical Center of Northwestern University, Chicago, Illinois, USA.

Testicular toxoplasmosis is a very rare presentation of A 26-year-old immunocompetent man presented to us with right testicular pain and a right epididymal mass. Ultrasound was concerning for malignancy and a radical orchiectomy was performed. Surgical pathology revealed chronic granulomatous inflammation which stained positive for . Read More

BMJ Case Rep 2018 Jun 4;2018. Epub 2018 Jun 4.

Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Testicular plasmacytomas are rare, accounting for only 1.3% of all extramedullary plasmacytomas. The infrequency in which it is encountered, coupled with its non-specific clinical and sonographic presentation, makes its diagnosis a challenge. Read More

Medicine (Baltimore) 2018 Jun;97(22):e10736

Department of Urology, the First Affiliated Hospital of GuangXi Medical University.

Rationale: Cutaneous metastasis of testicular choriocarcinoma is exceptionally uncommon. To our knowledge, only 14 cases have been reported in the past 10 years in the pubmed. We have an uncommon case of testicular choriocarcinoma who has metastasized to the adjacent skin and organ systems. Read More

J Med Case Rep 2018 May 28;12(1):149. Epub 2018 May 28.

Department of Andrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.

Background: Intrascrotal embryonal rhabdomyosarcoma in adults is a rare tumor with high aggression and a poor prognosis. We report our patient's case and review the relevant literature to improve the understanding of this rare disease.

Case Presentation: A 21-year-old Han Chinese man presented to our hospital with a right intrascrotal mass of 1 year's duration. Read More

Am J Surg Pathol 2018 Aug;42(8):1113-1120

The Johns Hopkins Medical Institutions, Baltimore, MD.

The clinical significance of limited choriocarcinoma in a malignant mixed germ cell tumor (MGCT) is unknown. Men with a MGCT with ≤5% choriocarcinoma at radical orchiectomy (RO) between 2000 and 2016 from our consult service were studied. Of 50 men in our cohort, we had clinical information for 30 men. Read More

J BUON 2018 Mar-Apr;23(2):439-443

Department of Urology, Polytechnic University of Marche Region, University Hospital "Ospedali Riuniti", Ancona, Italy.

Purpose: To analyze the dimensional characteristics between non-palpable testicular masses detected during ultrasonographic (US) study and their postoperative dimensions reported in definitive histological diagnosis, and evaluate if the sonographic measurements may be a relevant parameter to improve the identification of testicular lesions amenable to treatment with testicular-sparing surgery (TSS).

Methods: A total of 77 patients who underwent radical orchiectomy or TSS for non-palpable testicular masses suspected for malignant neoplasms were included into this study. Preoperative US studies were also carried out in all patients to evaluate the diameter, volume and sonographic characteristics of the testicular lesions and the contralateral testes. Read More

Zhonghua Nan Ke Xue 2017 Dec;23(12):1103-1106

Department of Urology, Shanghai General Hospital / Shanghai Yiyuan School of Clinical Medicine, Nanjing Medical University, Shanghai 200080, China.

Objective: To report a rare case of epididymal liposarcoma with multiple metastases to the retroperitoneal space and peritoneal cavity for the purpose of improving the diagnosis and treatment of the disease.

Methods: We retrospectively analyzed the clinical data about a case of epididymal liposarcoma with multiple metastases to the retroperitoneal space and peritoneal cavity, reviewed relevant literature at home and abroad, and investigated the presentation, diagnosis and treatment of the disease.

Results: A 47-year-old male patient with epididymal liposarcoma underwent radical left orchiectomy with high ligation of the spermmatic cord. Read More

J Pediatr Urol 2018 Oct 3;14(5):443.e1-443.e7. Epub 2018 Apr 3.

Department of Pediatric Urology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Introduction: Prepubertal testicular tumors are fundamentally distinct from their postpubertal and adult counterparts. Racial and ethnic differences contribute to the incidence, characteristics, and histological distribution of prepubertal testicular germ cell tumors (PTGCTs).

Objective: To elucidate the characteristics and treatment outcomes of PTGCTs in a Chinese cohort. Read More

BJU Int 2018 08 17;122(2):236-242. Epub 2018 Apr 17.

Department of Urology, Guy's Hospital, London, UK.

Objectives: To determine the frequency of spermatogenesis in patients with testicular cancer and to assess for any predictors of spermatogenesis.

Patients And Methods: We retrospectively reviewed 103 testicular germ cell tumours (TGCTs) in men who underwent radical orchidectomy conducted at Guy's Hospital, London, between 2011 and 2015. Primary outcome measures included: the presence and characteristics of spermatogenesis (widespread/focal/proximity to tumour). Read More

Clin Exp Reprod Med 2018 Mar 30;45(1):44-47. Epub 2018 Mar 30.

Department of Urology, Reproduction Center, Yokohama City University Medical Center, Yokohama, Japan.

Onco-testicular sperm extraction is used to preserve fertility in patients with bilateral testicular tumors and azoospermia. We report the case of a testicular tumor in the solitary testis of a patient who had previously undergone successful contralateral orchiectomy and whose sperm was preserved by onco-testicular sperm extraction. A 35-year-old patient presented with swelling of his right scrotum that had lasted for 1 month. Read More

Cureus 2018 Feb 13;10(2):e2188. Epub 2018 Feb 13.

Department of Urology, Keck School Of Medicine at USC.

Paratesticular serous papillary carcinomas are very rare, with less than 40 cases reported in the literature. These neoplasms are Müllerian in origin, and more commonly seen as epithelial-type ovarian cancer. Given the rarity of this tumor in men, staging and recommended treatment options do not exist. Read More

Fertil Steril 2018 04;109(4):745

Department of Urology, University of Miami Miller School of Medicine, Miami, Florida; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.

Objective: To demonstrate a step-by-step approach to the use of the operating microscope for onco-testicular sperm extraction.

Design: Video presentation.

Setting: University hospital. Read More

Arch Ital Urol Androl 2018 Mar 31;90(1):68-69. Epub 2018 Mar 31.

Hospital de Santa Maria, Urology Department, Lisbon.

Objective: To present a case of a bilateral synchronous testicular seminoma in a young male clinical stage IIB.

Material And Method: A 37 years old man presented a bilateral testicular mass with elevated tumoral markers. Histology of frozen section revealed bilateral seminoma and bilateral radical orchiectomy was performed. Read More

Urology 2018 Jul 4;117:145-149. Epub 2018 Apr 4.

Department of Pathology, University of Michigan, Ann Arbor, MI. Electronic address:

An otherwise healthy 7-year-old boy was diagnosed with malignant large cell calcifying Sertoli cell tumor (LCCSCT) of the testis. He underwent attempted partial orchiectomy with conversion to radical orchiectomy due to suspected malignancy on intraoperative frozen section. There was no lymph node or visceral metastases. Read More

Asian J Androl 2018 Sep-Oct;20(5):520-522

Department of Urology, The First Hospital of Jilin University, Changchun 130021, China.

Urology 2018 Jul 30;117:142-144. Epub 2018 Mar 30.

Department of Ultrasound, Tianjin Children's Hospital, Tianjin, China.

Yolk sac tumor (YST) is a rare malignancy typically occurring in children. However, bilateral testicular YSTs are a quite rare situation, which can occur metachronously or synchronously with same histologic type, as well as different histology. We present a case of synchronous YST of the left testis and mature teratoma of the right in a 7-month-old infant treated with testis-sparing surgery at right testis and high radical orchiectomy at left. Read More

World J Urol 2018 Aug 23;36(8):1263-1266. Epub 2018 Mar 23.

Department of Urology, Medical Faculty, Ankara University, Ankara, Turkey.

Purpose: Colour Doppler ultrasound (CDUS) is the main radiologic tool to evaluate scrotal masses and intratesticular-vascularised solid lesions are mostly considered malign lesions. Objective of this trial is determine ratio of benign lesions in patients with hypervascularised solid intratesticular lesions.

Material And Method: Patients who underwent radical orchiectomy due to hypervascularised intratesticular solid lesions detected in CDUS are evaluated retrospectively. Read More

Mol Clin Oncol 2018 Apr 15;8(4):617-622. Epub 2018 Feb 15.

Department of Urology, Peking University Shenzhen Hospital, Shenzhen 518036, P.R. China.

Paratesticular liposarcoma is an infrequent tumor characterized by a growing, painless, inguinal or scrotal mass. Only about 200 cases have been reported as of yet in literature, however there are a few cases regarding giant paratesticular liposarcoma measuring over 10 cm. The disease may be commonly misdiagnosed prior to operation. Read More

J Pediatr Hematol Oncol 2019 Jan;41(1):74-76

Rare Tumors Program, Texas Children's Cancer Center, Baylor College of Medicine.

Leydig cell tumors (LCTs) are rare tumors arising from testosterone-producing Leydig cells. Although LCTs are usually benign, malignancy has been reported in 10% of cases in adults, and local recurrence or metachronous tumors of the contralateral testis have been described. Radical orchiectomy is the current standard of care. Read More

Ann Clin Lab Sci 2018 Jan;48(1):120-125

Department of Hematology, the Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, China

High-dose chemotherapy combined with autologous hematopoietic stem-cell transplantation (ASCT) is the first-line treatment for multiple myeloma. Yet, some patients will relapse. Testicular plasmacytoma which rarely happens can be isolated or associated with progressive multiple myeloma. Read More