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Medicine (Baltimore) 2021 Jun;100(24):e26381

Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute.

Rationale: The use of cisplatin in patients with chronic kidney disease (CKD) is risky and depends on a number of factors. The optimal procedure in stage I of a non seminomatous germ cell tumor without proven lymphangioinvasion after orchiectomy is controversial and is the subject of a number of discussions due to the lack of randomized studies assessing individual treatment options. The adjuvant method of choice is surveillance or application of cisplatin-based chemotherapy with the risk of treatment related nephrotoxicity. Read More

Urol Case Rep 2021 Sep 25;38:101653. Epub 2021 Mar 25.

Department of Surgery, Maimonides Medical Center, Brooklyn, NY, 11219, USA.

The left ventricular assist device (LVAD) is an implanted mechanical pump that supports circulatory function for patients with advanced heart failure. LVAD survival has continuously improved over the last decade with an increasing number of patients requiring non-cardiac surgeries. We discuss a 77-year-old, LVAD-dependent male with an enlarging, indurated right testicular mass. Read More

Urologia 2021 Jun 9:3915603211022942. Epub 2021 Jun 9.

Urology Department, University of Health Sciences Tepecik Education and Research Hospital, Izmir, Turkey.

Introduction: Malignant mesothelioma (MM) of tunica vaginalis is a very rare tumor and it has a poor prognosis. It is not easy to diagnose the disease preoperatively because there is a lack of comprehensive studies and information about the disease. We would like to present our two cases with severe scrotal edema and hydrocele, which were debrided perioperatively due to scrotal necrosis, followed by radical inguinal orchiectomy and subsequently diagnosed as MM of tunica vaginalis. Read More

Surg J (N Y) 2021 Apr 3;7(2):e83-e91. Epub 2021 Jun 3.

Department of Urology/General Surgery, Areteion Hospital, Athens, Greece.

The diagnosis and timely treatment of cancer patients should not be compromised during an infectious disease pandemic. The pandemic of coronavirus disease 2019 (COVID-19) has serious implications on urology practice and raises particular questions for urologists about the management of different conditions. It was recommended to cancel most of the elective urological surgeries. Read More

Mod Pathol 2021 Jun 8. Epub 2021 Jun 8.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Testicular Leydig cell tumor (LCT), the most common sex-cord stromal tumor in men, represents a small fraction of all testicular tumors (~1 to 3%). Although most testicular LCTs are indolent and cured by radical orchiectomy, 5-10% have aggressive biology and metastatic potential. In primary LCTs, large size, cytologic atypia, necrosis, increased mitotic activity, and vascular invasion have been associated with clinically aggressive tumors. Read More

Res Rep Urol 2021 24;13:283-288. Epub 2021 May 24.

Department of Urology, Odense University Hospital, Odense, Denmark.

Introduction: Chronic scrotal pain (CSP) can be a debilitating condition for patients and is often difficult to characterize.

Methods: A review of literature was performed using Embase, Cochrane and Medline databases in the period 1.January 2010 to 1. Read More

Int J Surg Case Rep 2021 May 21;83:105996. Epub 2021 May 21.

Faculty of medicine and Pharmacy Marseille, Department of Urology A, University Hospital Center Ibn Sina, Rabat, Morocco.

Introduction And Importance: Leiomyosarcoma is a malignant mesenchymal tumor derived from the smooth muscle, it represents approximately 7% of all soft tissue sarcomas. Male genitourinary leiomyosarcomas are rare (Abdullazade et al., 2013 [1]). Read More

J Int Med Res 2021 May;49(5):3000605211003773

Department of Urology, People's Hospital of Hebei Province, Shijiazhuang, Hebei Province, China.

We report the disease characteristics, diagnosis, and treatment of granulomatous orchitis. A 38-year-old man presented with a history of intermittent swelling, pain, and discomfort in the right testicle of 3 days' duration. Unenhanced magnetic resonance imaging (MRI) of the testis and scrotum revealed an oval mass in the right testis measuring approximately 17 mm in diameter, with clear borders and a target ring-like appearance from periphery to center. Read More

Urol Case Rep 2021 Sep 14;38:101718. Epub 2021 May 14.

Department of Urology and Andrology, University Hospital Yalgado Ouedraogo of Ouagadougou, Burkina Faso.

Adult Granulosa Cell Tumor of the Testis (AGCTT) is a rare sex-cord stromal tumor. About 73 cases have been previously reported in the literature. We report a case of AGCTT in a 64 years old male, located in the left testis. Read More

Minerva Urol Nephrol 2021 May 5. Epub 2021 May 5.

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Introduction: The prevalence of testicular tumor is constantly increasing, with an estimated incidence rate of about 3-10 new cases per 100,000 males/per year. Radical orchiectomy or testis sparing surgery (TSS) are recognized therapeutic approaches in these cases. However, the risk for hypogonadism and infertility is higher with the former compared with the latter. Read More

Iran J Pathol 2021 21;16(2):232-236. Epub 2020 Dec 21.

Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Iran.

Germ cell teratomas belong to non-seminomatous germ cell tumors and account for 95% of malignant testicular tumors. Regarding the current World Health Organization (WHO) criteria, testicular teratomas are divided into prepubertal and post-pubertal subtypes based on patients' age. The term "burned-out testicular tumor" is a very rare condition referring to a regressed testicular tumor which presents with its metastases without any clinical finding in the testicle. Read More

FP Essent 2021 Apr;503:23-27

University of Michigan Medical School Department of Family Medicine, 300 North Ingalls St NI4C06, Ann Arbor, Michigan 48109-5435.

Scrotal and testicular conditions include benign masses, infections, testicular torsion, and testicular cancer. Common palpable benign scrotal masses include spermatocele, varicocele, and hydrocele. Most patients with these masses require no treatment. Read More

Transl Androl Urol 2021 Mar;10(3):1342-1346

Department of Urology, University of Arizona College of Medicine, Tucson, AZ, USA.

Leiomyosarcoma (LMS) is one of the most common forms of soft tissue sarcoma with approximately 2,500 cases per year in the United States. The symptoms LMS vary depending upon the location, size, and spread of the tumor. In early stages, it may not be associated with any obvious symptoms so diagnosis and treatment may be delayed. Read More

Int J Surg Pathol 2021 Apr 13:10668969211008980. Epub 2021 Apr 13.

118084Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.

A 40-year-old, male, Japanese patient presented with the complaint of painless, right testicular swelling. Tumor markers for testicular cancer were normal. He underwent radical orchiectomy with the clinical diagnosis of stage I seminoma. Read More

Urologia 2021 Apr 8:3915603211009118. Epub 2021 Apr 8.

Department of Urology, San Raffaele Turro Hospital, San Raffaele University, Milan, Italy.

Introduction: We aim to present a rare case of a patient who developed a late testicular metastasis of PCa after radical prostatectomy.

Case Description: A 78 years old man presenting for left testicular swelling slowly increasing of size over the last 2 months. He underwent a retropubic radical prostatectomy and extended bilateral lymphadenectomy in 2007 for prostatic adenocarcinoma. Read More

Front Oncol 2021 17;11:629878. Epub 2021 Mar 17.

Department of Urology, Jinhua Hospital Affiliated to Zhejiang University School of Medicine, Jinhua, China.

Paratesticular rhabdomyosarcoma (RMS) accounts for only 7% of all the RMS cases. Due to the limited available data, there is no consensus on the diagnosis and management of the paratesticular tumors. Here, we interrogated two paratesticular RMS cases in 25 and 27-year-old men presenting with painless and rapidly growing mass in the scrotum. Read More

Arch Ital Urol Androl 2021 Mar 22;93(1):120-126. Epub 2021 Mar 22.

Division of Urology, University Hospital "Ospedali Riuniti", School of Medicine, Department of Clinical, Special and Dental Sciences, Marche Polytechnic University, Ancona.

This collection includes some unusual cases and how they were diagnosed and treated. Case 1: A case of a patient with primary hyperthyroidism presenting with a submucosal ureteral stone after endoscopic lithotripsy was described. After multiple endoscopic treatment, the stone was successfully removed by open ureterolithotomy recovering ureteral patency and normal renal function. Read More

Int J Surg Case Rep 2021 Apr 6;81:105725. Epub 2021 Mar 6.

Urology Department, Les Aghlabides Surgical Division, Ibn Jazzar Teaching Hospital, Rue Hassan Ibn Nouaman, 3100, Kairouan, Tunisia. Electronic address:

Liposarcoma of the spermatic cord is very rare, representing about 7% of para testicular sarcomas. It is considered to be one of the highest malignancy grades. We present a case of a liposarcoma of the spermatic cord in a 45-year-old male complaining of a progressive painless swelling in the right inguinoscrotal region. Read More

Ann Surg Oncol 2021 Jul 10;28(7):3648-3655. Epub 2021 Mar 10.

Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Purpose: Following radical orchiectomy, surveillance and primary retroperitoneal lymph node dissection (RPLND) are acceptable options for the management of early stage pure testicular teratoma in adult patients; however, there is no uniform consensus. The aim of this study was to investigate survival outcomes of adults with early stage pure testicular teratoma based on management strategy.

Methods: Data was extracted from the National Cancer Database (NCDB) from testicular cancer patients diagnosed with clinical stage (CS) I pure teratoma (pT1-4N0M0S0) between 2004 and 2014. Read More

Pan Afr Med J 2020 7;37:319. Epub 2020 Dec 7.

Department of Oncology, Kingston General Hospital, Ontario, Canada.

Bilateral testicular germ cell tumors (BTGCT) occur in 1 to 4% of patients with testicular cancer and of these, 10-15% are synchronous. Overall, BTGCT represents less than 0.5% of all new cases of testicular cancer. Read More

BMC Surg 2021 Mar 6;21(1):116. Epub 2021 Mar 6.

Department of Urology, Montefiore Medical Center, Bronx, NY, USA.

Background: The first wave of the COVID-19 pandemic in March 2020 forced our healthcare system in the Bronx, New York to cancel nearly all scheduled surgeries. We developed a framework for prioritizing postponed urologic surgeries that was utilized once cases were permitted to be rescheduled. As many parts of our country experience first and second waves of this pandemic, our framework may serve as a resource for other centers experiencing restrictions on the scheduling of elective urologic surgeries. Read More

Cancer Manag Res 2021 23;13:1897-1900. Epub 2021 Feb 23.

Department of Urology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, People's Republic of China.

The metastasis of gastric cancer to the testis or spermatic cord is very rare; however, simultaneous testicular and spermatic cord metastases are even rarer. Here, we report an unusual case of a 54-year-old male patient who had undergone radical gastrectomy for gastric adenocarcinoma more than two years before. He complained of palpable painful masses in the right scrotum and inguinal area occurring for more than half a year. Read More

BMJ Case Rep 2021 Mar 2;14(3). Epub 2021 Mar 2.

Urology Department, Altnagelvin Hospital, Western Health and Social Care Trust, Derry, UK.

A 74-year-old man with a history of prostate cancer was referred to the urology team with a new left sided testicular lump. He had a background of prostate cancer 4 years previous which had been treated with external beam radiotherapy and androgen deprivation therapy, both of which had been completed. Concurrently, he also had evidence of biochemical recurrence of prostate cancer with a rising prostate-specific antigen (PSA). Read More

J Urol 2021 Jun 22;205(6):1569-1576. Epub 2021 Feb 22.

Department of Urology, IRCCS San Raffaele Hospital and Scientific Institute, Milan, Italy.

Purpose: Men with nonseminomatous germ cell tumors of the testicle without evidence of residual disease after radical orchiectomy (clinical stage I) are increasingly managed with active surveillance. The guideline-recommended cornerstones of surveillance are conventional serum tumor markers and computerized tomography. The reliability of serum tumor markers as a tool to diagnose early recurrence of clinical stage I nonseminomatous germ cell tumors is unclear. Read More

Radiol Case Rep 2021 Apr 9;16(4):923-928. Epub 2021 Feb 9.

Healthpoint Medical Center, Amman, Jordan.

Pure testicular choriocarcinoma is an extremely rare subtype of nonseminomatous germ cell tumor, accounting for less than 1% of all germ cell tumors and only 0.19% of all testicular tumors. It is a highly aggressive malignant tumor with early multiorgan metastasis and poor prognosis. Read More

Recent Pat Anticancer Drug Discov 2021 ;16(1):44-53

Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, P.R. China

Background: Testicular Germ Cell Tumor (TGCT) is the most common malignant tumor in young men, but there is a lack of a prediction model to evaluate the prognosis of patients with TGCT.

Objective: To explore the prognostic factors for Progression-Free Survival (PFS) and construct a nomogram model for patients with early-stage TGCT after radical orchiectomy.

Methods: Patients with TGCT from The Cancer Genome Atlas (TCGA) database were used as the training cohort; univariate and multivariate cox analysis was performed. Read More

Urologia 2021 Feb 10:391560321993584. Epub 2021 Feb 10.

Okmeydani Training and Research Hospital, Istanbul, Turkey.

Purpose: Testicular cancer is mostly seen in young men. We planned this study that neutrophil-lymphocyte ratio (NLR) would help us predict the prognosis of the patients, except known markers such as AFP, hCG, and LDH.

Patients And Method: Between 2015 and 2020, we conducted our study on 152 patients undergoing radical orchiectomy in our clinic. Read More

BMC Urol 2021 Feb 3;21(1):16. Epub 2021 Feb 3.

Department of Urology, The Children's Hospital, Zhejiang University, School of Medicine, National Clinical Research Center for Child Health, 57 Zhugan Xiang, Hangzhou, 310053, China.

Background: Splenogondal fusion (SGF) is a rare congenital anomaly characterized by abnormal association between the splenic tissue and the gonads or mesonephric remnants. SGF that requires separate two-stage laparoscopic staged Fowler-Stephen orchiopexy on both the left and right sides is extremely rare. SGF could be misdiagnosed as testicular malignancy and leads to unnecessary orchiectomy. Read More

Urol Case Rep 2021 May 20;36:101572. Epub 2021 Jan 20.

Men's Health and Reproductive Health Research Center (IRHRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

A 34-year-old man presented with bloody urethral discharge, dysuria, cough and right testicular mass. He had a history of anterior urethral stricture and multiple urethral dilation procedures. Radical orchiectomy and urethral mass biopsy were performed. Read More

J Med Case Rep 2021 Jan 31;15(1):37. Epub 2021 Jan 31.

Department of pathology, Kilimanjaro Christian Medical Centre (KCMC), Moshi, Tanzania.

Background: The importance of this paper is to help to emphasize the importance of chemotherapy for children with pure intratesticular rhabdomyosarcoma after radical inguinal orchiectomy is done as first treatment of rhabdomyosarcoma. The information provided in this paper about the follow-up outcomes of the patient described in this paper, it highlights that, recurrence and even metastasis of intratesticular rhabdomyosarcoma in children are more likely to occur if surgery it not combined with chemotherapy.

Case Presentation: Herein, we present a 6-year old African male child with a 3 months history of a painless right intratesticular tumour. Read More