1,282 results match your criteria Orchiectomy Radical


Global change of surgical and oncological clinical practice in urology during early COVID-19 pandemic.

World J Urol 2020 Jul 4. Epub 2020 Jul 4.

Department of Urology, University Medical Center, Johannes Gutenberg University, Langenbeckstr. 1, 55131, Mainz, Germany.

Objectives: While the coronavirus disease 2019 (COVID-19) pandemic captures healthcare resources worldwide, data on the impact of prioritization strategies in urology during pandemic are absent. We aimed to quantitatively assess the global change in surgical and oncological clinical practice in the early COVID-19 pandemic.

Methods: In this cross-sectional observational study, we designed a 12-item online survey on the global effects of the COVID-19 pandemic on clinical practice in urology. Read More

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http://dx.doi.org/10.1007/s00345-020-03333-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335229PMC

Giant paratesticular liposarcoma with lung metastases: a case report and review of the literature.

J Med Case Rep 2020 Jul 2;14(1):86. Epub 2020 Jul 2.

Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.

Background: Due to its rarity, little is known about the clinical presentations and responses to systemic chemotherapies in advanced and/or metastatic cases of paratesticular liposarcoma.

Case Presentation: Here, we report the case of a 75-year-old Japanese man with giant paratesticular liposarcoma. Imaging studies revealed a 26 cm tumor in his right scrotum and lung metastases at presentation. Read More

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http://dx.doi.org/10.1186/s13256-020-02420-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330966PMC

Pleomorphic rhabdomyosarcoma of the spermatic cord and a secondary hydrocele testis: A case report.

World J Clin Cases 2020 Jun;8(12):2641-2646

Department of Urology, The Second Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China.

Background: Pleomorphic rhabdomyosarcoma (RMS) of the spermatic cord is a group of rare neoplasms, and a secondary hydrocele testis occasionally occurs. The misdiagnosis of paratesticular mass may lead to a therapeutic delay.

Case Summary: A 79-year-old man presented to our clinic complaining of a 1-mo history of painless scrotal swelling. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i12.2641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322420PMC

The role of preoperative albumin to globulin ratio in predicting prognosis in testicular cancer patients.

Authors:
E Guner K G Seker

Actas Urol Esp 2020 Jun 26. Epub 2020 Jun 26.

Department of Urology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Estambul, Turquía.

Introduction And Objectives: In recent years, the incidence of testicular cancer has increased, but mortality rates have decreased thanks to the improvements in treatment. Although primary tumor characteristics and serum tumor markers are associated with metastasis and relapse, their predictive value is not reliable. Therefore, there is a need for new biomarkers that predict prognosis. Read More

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http://dx.doi.org/10.1016/j.acuro.2020.03.011DOI Listing

Discrepancy in pathology reports upon second review of radical orchiectomy specimens for testicular germ cell tumors.

Can Urol Assoc J 2020 Jun 16. Epub 2020 Jun 16.

Division of Urology, Department of Surgery, Princess Margaret Cancer Centre, Toronto, ON, Canada.

Introduction: We sought to evaluate the discrepancies between primary pathology report and second pathology review of radical orchiectomy (RO) specimens.

Methods: A retrospective review was performed of RO specimens from the Ontario Cancer Registry. All cases required both a primary pathology report and a second pathology review from another institution. Read More

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http://dx.doi.org/10.5489/cuaj.6481DOI Listing

Diagnostic performance of multi-parametric MRI to differentiate benign sex cord stromal tumors from malignant (non-stromal and stromal) testicular neoplasms.

Abdom Radiol (NY) 2020 Jun 22. Epub 2020 Jun 22.

Department of Radiology, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.

Purpose: Testicular stromal tumors are uncommon, although mostly benign. The purpose of this study is to assess the role of multi-parametric MRI in differentiating benign testicular stromal tumors from malignant testicular neoplasms (non-stromal and stromal).

Methods: A single-center retrospective study comparing benign stromal tumors (STs) to malignant testicular neoplasms (MTNs) was conducted. Read More

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http://dx.doi.org/10.1007/s00261-020-02621-4DOI Listing

A testosterone-producing Leydig cell tumor metastasis during hormonal treatment of prostate cancer.

Urol Ann 2020 Apr-Jun;12(2):180-183. Epub 2020 Apr 14.

Department of Urology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

We describe a patient with a testosterone-producing metastasis discovered during the follow-up of prostate cancer. The patient had a history of a Leydig cell tumor (LCT) in the right testicle for which he underwent radical orchiectomy at the age of 60 years. Within a year after orchiectomy, he was diagnosed with prostate cancer. Read More

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http://dx.doi.org/10.4103/UA.UA_38_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292439PMC

Dedifferentiated liposarcoma of the spermatic cord: Case report and review of literature.

Int J Surg Case Rep 2020 Jun 12;72:418-422. Epub 2020 Jun 12.

Department of Urology, Kendall Regional Medical Center, Miami, FL, USA.

Introduction: Malignant spermatic cord tumors have an annual incidence of 0.3 cases/million. The vast majority of tumors in this region are benign. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306526PMC

Current insights into interethnic variability in testicular cancers: Population pharmacogenetics, clinical trials, genetic basis of chemotherapy-induced toxicities and molecular signal transduction.

Curr Top Med Chem 2020 Jun 18. Epub 2020 Jun 18.

SVKM's Dr. Bhanuben Nanavati College of Pharmacy, University of Mumbai, V. L. Mehta Road, Vile Parle (West), Mumbai - 400 056. India.

Testicular cancer is an aggressive malignancy with a rising incidence rate across the globe. Testicular germ cell tumors are the most common diagnoses, and surgical removal of the testes is often a radical necessity along with chemotherapy and radiotherapy. While seminomas are receptive to radiotherapy as well as chemotherapy, non-seminomatous germ cell tumors respond to chemotherapy only. Read More

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http://dx.doi.org/10.2174/1568026620666200618112205DOI Listing

Intratesticular leiomyoma: A case report and a literature review.

Int J Surg Case Rep 2020 23;71:217-221. Epub 2020 May 23.

Urology Department, Sahloul Hospital, Sousse, Tunisia.

Introduction: Leiomyomas are benign tumors that originate from smooth muscles cells. Intratesticular leiomyoma is a very rare type of benign testicular masses. Through the literature, only 11 cases were reported. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262370PMC

Testicular tumours in children: an approach to diagnosis and management with pathologic correlation.

Insights Imaging 2020 May 27;11(1):74. Epub 2020 May 27.

Pediatric Urology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Testicular tumours are rare in children. Painless scrotal mass is the most frequent clinical presentation. Tumoural markers (alpha-fetoprotein, beta-human gonadotropin chorionic) and hormone levels (testosterone) contribute to the diagnosis and management of a testicular mass in boys. Read More

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http://dx.doi.org/10.1186/s13244-020-00867-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253550PMC

Denial and oncological pathology: Case report of a massive testicular cancer.

Urologia 2020 May 27:391560320921714. Epub 2020 May 27.

Department of Urology, University of Turin, Torino, Italy.

Literature: The cancer of testicles represents 1% of male neoplasms and 5% of urological malignant neoplasm. Its incidence has been growing in Western societies. Cancer of testicles usually presents as an increase of consistence in one testicles and absence of pain, as a casual ultrasound scan finding, or it could be highlighted by a scrotal injury. Read More

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http://dx.doi.org/10.1177/0391560320921714DOI Listing

Benign testicular cavernous hemangioma presenting with acute onset: A case report.

Mol Clin Oncol 2020 Jul 23;13(1):19-22. Epub 2020 Apr 23.

Department of Andrology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

Cavernous hemangioma is a congenital, benign vascular tumor that occurs in the deep dermis and subcutaneous tissue. Testicular cavernous hemangioma is extremely rare, mostly occurring during childhood or adolescence. Testicular cavernous hemangioma is a benign tumor that appears as a slowly growing painless mass. Read More

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http://dx.doi.org/10.3892/mco.2020.2033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241247PMC

[Recurrence-Free Survival after Repeated Resections for Metastatic Inguinal Tumor in Colorectal Mucinous Adenocarcinoma-A Case Report].

Gan To Kagaku Ryoho 2020 Jan;47(1):123-125

Dept. of Surgery, Funabashi Municipal Medical Center.

A 79-year-old male presented with right inguinal mass and right leg pain. Laparoscopic right hemicolectomy was performed for transverse colon cancer(type 1, muc, pSS, pN1a, pStage Ⅲa)3 years and 6 months ago. We resected the mass located in the spermatic cord and reconstructed it using the Direct Kugel Patch. Read More

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January 2020

Insertion of a testicular prosthesis at the time of radical orchiectomy for testicular cancer is safe in patients who will subsequently undergo chemotherapy or radiotherapy.

Andrologia 2020 Jul 30;52(6):e13613. Epub 2020 Apr 30.

Division of Urology, European Institute of Oncology, IRCCS, Milan, Italy.

We aimed to assess the incidence of prosthesis-related complications in patients who received a testicular prosthesis at the time of radical orchiectomy for testicular cancer and were then treated with chemotherapy (ChT) or radiotherapy (RT). We reviewed the records of the patients who underwent radical orchiectomy at our Institute since 1999; we also retrieved data from patients who underwent surgery elsewhere and then received ChT or RT at our Institution since 1999. We used the chi-square test to evaluate differences in the incidence of prosthesis-related complications between the groups. Read More

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http://dx.doi.org/10.1111/and.13613DOI Listing

Imaging appearance of cystic and solid mesothelioma of the tunica vaginalis.

Radiol Case Rep 2020 Jul 22;15(7):809-811. Epub 2020 Apr 22.

University of Nebraska Medical Center, Omaha, NE, USA.

We present the case of a 32-year-old male who presented with a growing scrotal mass initially diagnosed as benign adenomatoid tumor on ultrasound 6 years prior. Repeat ultrasound showed an abnormal extra-testicular mass with nodular and cystic components and internal vascularity. A computed tomography scan of the abdomen and pelvis confirmed a right extra-testicular scrotal mass with cystic and solid enhancing components. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182692PMC

Diffuse Large B-cell Lymphoma of Testis: a Case Report and Current Literature Review.

Folia Med (Plovdiv) 2020 03;62(1):200-203

Haseki Training and Research Hospital, Istanbul, Turkey.

Introduction: Testicular cancers detected in older males are mostly testicular lymphomas. Primary testicular lymphoma (PTL) is a rare, clinically aggressive form of extranodal lymphoma. In population-based studies, the incidence of PTL is 0. Read More

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http://dx.doi.org/10.3897/folmed.62.e47874DOI Listing

Partial orchiectomy: The Princess Margaret cancer centre experience.

Urol Oncol 2020 Jun 10;38(6):605.e19-605.e24. Epub 2020 Apr 10.

Division of Urology, Department of Surgery, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, ON, Canada. Electronic address:

Introduction: Radical orchiectomy (RO) is the standard treatment for a testis cancer. Organ sparing surgery can be considered in the setting of a solitary functioning testis or bilateral tumors. It has also been suggested as an alternative to RO for small lesions. Read More

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http://dx.doi.org/10.1016/j.urolonc.2020.03.012DOI Listing

[Clinical characterization of testicular yolk sac tumor in children and adults].

Zhonghua Nan Ke Xue 2019 Feb;25(2):144-149

Department of Urology / Urology Institute of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

Objective: To compare the clinical characteristics of simple testicular yolk sac tumor (YST) in children with those in adults so as to improve the diagnosis and treatment of the malignance.

Methods: This study included 75 cases of simple testicular YST pathologically confirmed between May 2008 and July 2018, which were divided into groups A (aged <18 years, n = 64) and B (aged ≥18 years, n = 11). We analyzed the clinical data on all the cases and compared the clinical manifestations, laboratory results, pathological findings, clinical stages, treatment methods and prognostic outcomes between the two groups of patients. Read More

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February 2019

Testis-sparing surgery and scrotal violation for testicular masses suspicious for malignancy: A systematic review and meta-analysis.

Urol Oncol 2020 May 17;38(5):344-353. Epub 2020 Mar 17.

Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD.

Radical inguinal orchiectomy is the standard of care for men diagnosed with a testicular mass suspicious for germ cell tumor (TGCT). Nontraditional approaches to management, including testis-sparing surgery (TSS) and scrotal orchiectomy, occur in clinical practice. We systematically reviewed studies evaluating outcomes after TSS and scrotal violation for the management of a suspected TGCT. Read More

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http://dx.doi.org/10.1016/j.urolonc.2020.02.023DOI Listing

Metastatic Renal Cell Carcinoma to the Testis: A Clinicopathologic Analysis of Five Cases.

Case Rep Pathol 2020 2;2020:9394680. Epub 2020 Mar 2.

Department of Pathology, Vancouver General Hospital, Vancouver, BC, Canada.

The testicular spread of renal cell carcinoma is extremely rare. Five cases of renal cell carcinoma metastatic to the testis are described. The patients ranged from 45 to 81 years of age. Read More

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http://dx.doi.org/10.1155/2020/9394680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073490PMC

The utility of De Ritis Ratio in predicting prognosis in testicular cancer.

Aktuelle Urol 2020 06 5;51(3):285-289. Epub 2020 Mar 5.

Yuksek Ihtisas Training and Research Hospital, Urology, Ankara.

Objective: We aimed to investigate the possible association between testicular cancer prognosis and De Ritis ratio (AST/ALT).

Methods: The medical records of all patients who underwent radical inguinal orchiectomy at a single tertiary in Istanbul, Turkey between 2006 and 2017 were retrospectively analyzed. Investigated parameters included patients' demographics, complete blood count and blood biochemistry results, pathology results, treatment schemes, imaging results, and survival. Read More

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http://dx.doi.org/10.1055/a-1117-2776DOI Listing

Grossing and reporting of testicular tumor specimens : An evidence-based approach.

Indian J Cancer 2020 Jan-Mar;57(1):7-12

Department of Pathology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

The majority of testicular tumors are germ cell tumors (GCTs), but there are numerous other types, making testicular tumors one of the most diverse areas of human pathology, despite their relative rarity. Testicular tumors are usually diagnosed only after radical surgery, as biopsies are not performed. Further management of the patient is dependent on the diagnosis at microscopy, which itself is based on the sections taken at the time of grossing the specimen. Read More

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http://dx.doi.org/10.4103/ijc.IJC_1072_19DOI Listing

The clinical features and treatment options of intratesticular epidermoid cysts.

Arch Esp Urol 2020 Mar;73(2):126-131

Department of Urology. Gulhane Training and Research Hospital. Ankara. Turkey.

Objectives: In this study, we aimed to define the clinico-radiological data and treatment options for intratesticular epidermoid cysts (IEC). MATERIALS AND METHODS: We retrospectively reviewed the medical records of the patients that under went surgery for testicular mass between 1995 and 2017. Data of the patients whose histopathological evaluation revealed IEC were recorded. Read More

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Contemporary management of early stage testicular seminoma.

Transl Androl Urol 2020 Jan;9(Suppl 1):S36-S44

Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Therapy for early stage testicular seminoma has changed radically over the past several decades. Given high cure rates and clinical trials supporting less active therapy in most cases, close observation after radical orchiectomy is now considered standard of care for clinical stage (CS) IA/IB seminoma, with either radiation therapy (RT) or chemotherapy salvage options possible. For CS IIA/IIB seminoma characterized by non-bulky retroperitoneal lymph node involvement (≤5 cm in greatest dimension), RT or combination chemotherapy are the standard of care. Read More

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http://dx.doi.org/10.21037/tau.2019.09.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995845PMC
January 2020

Testis-preserving strategies in testicular germ cell tumors and germ cell neoplasia .

Transl Androl Urol 2020 Jan;9(Suppl 1):S24-S30

Department of Urology, Uro-Oncology, Robot Assisted and Reconstructive Urologic Surgery, University Hospital of Cologne, Cologne, Germany.

Testicular germ cell tumors (TGCT) are rare malignancies which affect young adults and adolescents between the ages of 15 and 40 years. In suspected malignant TGCT, the treatment of choice is radical orchiectomy. However, in specific cases this routine surgical approach has been challenged in favor of an organ-preserving approach with comparable oncological outcome. Read More

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http://dx.doi.org/10.21037/tau.2019.07.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995842PMC
January 2020

Paratesticular colon cancer metastasis in an area of remote trauma.

Authors:
Moshe Wald

BMJ Case Rep 2020 Feb 5;13(2). Epub 2020 Feb 5.

Urology, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA

A 53-year-old man with a history of colon adenocarcinoma and remote scrotal trauma resulting in a palpable nodule. Gradual increase in the size of this lesion over the year prior to his presentation to our clinic prompted scrotal ultrasound that demonstrated a 1.1 cm solid lesion, which appeared to arise from the right epididymal tail. Read More

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http://dx.doi.org/10.1136/bcr-2019-233106DOI Listing
February 2020

Inflammatory myofibroblastic tumor of the spermatic cord: two cases and review of the literature.

Ann Saudi Med 2020 Jan-Feb;40(1):66-71. Epub 2020 Feb 6.

From the Urology TC Saglik Bakanligi Haydarpasa Numune Egiim ve Arastirma Hastanesi, Istanbul, Turkey.

Inflammatory myofibroblastic tumor (IMT) is a neoplasm of intermediate biological potential. Few cases of spermatic cord IMT have been reported in the literature. Inflammatory myofibroblastic tumor is a consequence of the proliferation of fibroblasts and inflammatory cells. Read More

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http://dx.doi.org/10.5144/0256-4947.2020.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012034PMC
February 2020

Predictive and prognostic impact of preoperative complete blood count based systemic inflammatory markers in testicular cancer.

Int Braz J Urol 2020 Mar-Apr;46(2):216-223

Department of Urology, Trakya University School of Medicine, Edirne, Turkey.

Purpose: To determine the utility of preoperative complete blood count (CBC) based systemic inflammatory markers in the prediction of testicular cancer and its prognosis.

Material And Methods: Between 2008-2017 the data of all testicular tumor patients undergoing radical orchiectomy were retrospectively analyzed. Patient baseseline characteristics (age, tumor stage, tumor markers, etc. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0820DOI Listing

A Rare Case of Serous Papillary Ovarian Epithelial Type Carcinoma in Testis: A Rare Testicular Neoplasm.

J Family Reprod Health 2019 Jun;13(2):116-119

Department of Pathology, Shariati Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Ovarian epithelial type carcinomas of testis are an extremely rare group of tumors, a few cases of which having been reported. We present the case of a 67-year-old man, presented with testicular mass and inflation, who underwent radical orchiectomy and pathological and immunohistochemical assessments revealed serous papillary carcinoma of ovarian epithelial type tumor of testis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969893PMC

An Incidental Finding of Paratesticular Malignant Mesothelioma During Operation for Hydrocelectomy.

S D Med 2019 Nov;72(11):532-534

Sanford Health Pathology Clinic, Sioux Falls, South Dakota.

Paratesticular malignant mesothelioma is a rare and potentially aggressive malignancy, accounting for approxi- mately 0.3-1.4 percent of all malignant mesotheliomas. Read More

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November 2019

Primary rhabdomyosarcoma of tunica vaginalis misdiagnosing as hydrocele: A case report and literature review.

Andrologia 2020 Apr 21;52(3):e13517. Epub 2020 Jan 21.

Department of Urology, Shanghai Minhang Hospital, Fudan University, Shanghai, China.

Primary rhabdomyosarcoma of tunica vaginalis is very rare. We report a case of a 15-year-old man presenting as hydrocele. Pre-operatively, no masses were detected by ultrasonography. Read More

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http://dx.doi.org/10.1111/and.13517DOI Listing

Intratesticular Angiolipoma: A Rare Case of Adipose Tissue Presence in the Testis.

Case Rep Urol 2019 23;2019:7606530. Epub 2019 Dec 23.

2nd Department of Urology, Aristotle University of Thessaloniki, Greece.

Introduction: Solid, fat-containing tumors of the testes are extremely rare with only a few cases having been reported so far, contrary to the more frequent occurrence of paratesticular lipomatosis. Testicular angiomyolipomas and gonadal involvement in Cowden's disease, although infrequently occurring, are known examples of fat-bearing testicular lesions. Hereby, we present an extremely rare case of intratesticular angiolipoma. Read More

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http://dx.doi.org/10.1155/2019/7606530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942722PMC
December 2019

Isolated Testicular Metastasis Diagnosed More than a Decade and a Half Post Primary Treatment for Prostate Cancer.

Case Rep Oncol Med 2019 26;2019:4956954. Epub 2019 Nov 26.

Division of Urology, Department of Surgery, American University of Beirut-Medical Center, Riad El-Solh, 1107 2020 Beirut, Lebanon.

Prostate cancer is the most common visceral malignancy among men. It rarely metastasizes to the testicles. We herein present the case of a male patient who underwent a radical prostatectomy for a grade group 3 Gleason score 7 (4 + 3) prostate adenocarcinoma followed by adjuvant radiation therapy and continuous androgen deprivation therapy after his first biochemical recurrence. Read More

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http://dx.doi.org/10.1155/2019/4956954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899263PMC
November 2019

Classic Testicular Seminoma in Men Aged 50 Years or Over: A Case Report and Review of the Literature.

Case Rep Urol 2019 24;2019:4391015. Epub 2019 Nov 24.

Department of Urology, University of Balamand, Saint George Hospital University Medical Center, Beirut 1100 2807, Lebanon.

Testicular cancer is the most frequent solid tumor detected in young adult men. Germ cell tumors (GCTs), particularly seminomas, are the most common type of testicular neoplasms seen in that age population. Most publications have reported decreasing incidence of GCTs in patients above forty years of age. Read More

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http://dx.doi.org/10.1155/2019/4391015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906820PMC
November 2019

T2-Weighted Image-Based Radiomics Signature for Discriminating Between Seminomas and Nonseminoma.

Front Oncol 2019 28;9:1330. Epub 2019 Nov 28.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

To evaluate the performance of a T2-weighted image (T2WI)-based radiomics signature for differentiating between seminomas and nonseminomas. In this retrospective study, 39 patients with testicular germ-cell tumors (TGCTs) confirmed by radical orchiectomy were enrolled, including 19 cases of seminomas and 20 cases of nonseminomas. All patients underwent 3T magnetic resonance imaging (MRI) before radical orchiectomy. Read More

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http://dx.doi.org/10.3389/fonc.2019.01330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901122PMC
November 2019

Infantile synchronous primary bilateral testicular germ cell tumor: a case report and review of the literature.

Transl Androl Urol 2019 Oct;8(5):540-547

Department of Urology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Testicular tumors are uncommon in adults, accounting for <1% of all cancers, with testicular germ cell tumors (TGCTs) representing the majority (>95%) of reported cases. Adult and prepubertal TGCTs are fundamentally distinct and the latter is extremely rare, representing 1% of all pediatric solid tumors and having an annual incidence rate of 0.5-2/100,000 boys. Read More

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http://dx.doi.org/10.21037/tau.2019.09.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842785PMC
October 2019

Testicular Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2019 12;17(12):1529-1554

National Comprehensive Cancer Network.

Testicular cancer is relatively uncommon and accounts for <1% of all male tumors. However, it is the most common solid tumor in men between the ages of 20 and 34 years, and the global incidence has been steadily rising over the past several decades. Several risk factors for testicular cancer have been identified, including personal or family history of testicular cancer and cryptorchidism. Read More

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http://dx.doi.org/10.6004/jnccn.2019.0058DOI Listing
December 2019

The impact of age at orchiopexy on testicular cancer outcomes.

World J Urol 2019 Nov 28. Epub 2019 Nov 28.

Department of Urology, University of Kentucky, 800 Rose Street, MS 237, Lexington, KY, 40536, USA.

Purpose: To estimate how many boys with UDT must undergo orchiopexy to prevent one case of TC, one death from TC and one exposure to TC treatment beyond radical orchiectomy as compared to being treated at an older age.

Methods: This retrospective study utilized data from a 2007 Swedish study of males who underwent orchiopexy for UDT (Pettersson et al.). Read More

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http://dx.doi.org/10.1007/s00345-019-03034-9DOI Listing
November 2019

Rapid testicular metastasis from bladder transitional urothelial carcinoma after radical cystoprostatectomy: A case report.

Medicine (Baltimore) 2019 Nov;98(48):e18000

Department of Urology.

Rationale: Bladder cancer (BC) is commonly diagnosed in the urinary system and the most common subtype is transitional urothelial carcinoma (TCC). Even with the best treatment, tumor recurrence and metastases always occur. While clinicians commonly observe the metastases to pelvic lymph nodes, liver, lung, and bone, it may infrequently spread to some uncommon locations. Read More

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http://dx.doi.org/10.1097/MD.0000000000018000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890337PMC
November 2019

Management of Leydig cell tumors of the testis-a case report.

Urol Case Rep 2020 Jan 31;28:101064. Epub 2019 Oct 31.

Medical University Pleven, Bulgaria, "Georgi Kochev"8A str, 5800, Bulgaria.

We report 1 case of Benign Leydig cell tumor. A 45-year-old male was admitted to the Urology department with a large painless mass in the right testis of 1 year duration. The patient underwent radical high right orchiectomy, with a preliminary diagnosis of right testicular tumor. Read More

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http://dx.doi.org/10.1016/j.eucr.2019.101064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854074PMC
January 2020

Isolated testicular recurrence of B cell acute lymphoblastic leukaemia in an adult: rare case.

BMJ Case Rep 2019 10 31;12(10). Epub 2019 Oct 31.

Internal Medicine, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.

An 80-year-old man who was previously diagnosed with Philadelphia+ B cell-acute lymphoblastic leukaemia (B-ALL) in remission post-allogeneic matched unrelated donor peripheral blood stem cell transplant. Five years later, he was found to have unilateral testicular relapse of Philadelphia+ B-ALL proven by pathology after radical orchiectomy. Bone marrow aspirate and biopsy did not show evidence of leukaemia. Read More

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http://dx.doi.org/10.1136/bcr-2019-232286DOI Listing
October 2019
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A systematic review of treatment outcomes in localised and metastatic spermatocytic tumors of the testis.

J Cancer Res Clin Oncol 2019 Dec 23;145(12):3037-3045. Epub 2019 Oct 23.

Department of Urology, University Hospital, University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland.

Introduction: Because spermatocytic tumors of the testis are rare, only limited evidence exists regarding the malignant potential and the optimal management of localized and metastatic disease.

Materials And Methods: We performed a systematic review through MEDLINE, EMBASE, Scopus, Cochrane Database of Systematic Reviews and Web of Science to identify reports including patients with testicular spermatocytic tumors.

Results: From originally 7863 studies, we extracted data of 146 patients of which 99% were treated with radical orchiectomy. Read More

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http://link.springer.com/10.1007/s00432-019-03056-1
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http://dx.doi.org/10.1007/s00432-019-03056-1DOI Listing
December 2019
3 Reads

Testis Sparing Surgery of Small Testicular Masses: Retrospective Analysis of a Multicenter Cohort.

J Urol 2020 04 3;203(4):760-766. Epub 2019 Oct 3.

Sapienza University of Rome, Rome, Italy.

Purpose: We evaluated possible factors predicting testicular cancer in patients undergoing testis sparing surgery.

Materials And Methods: We retrospectively analyzed the records of all patients who underwent testis sparing surgery for a small testicular mass at a total of 5 centers. All patients with 1 solitary lesion 2 cm or less on preoperative ultrasound were enrolled in the study. Read More

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http://dx.doi.org/10.1097/JU.0000000000000579DOI Listing
April 2020
7 Reads

[Partial orchiectomy in testicular tumor: Surgical technique and role of intraoperatory ecography.]

Arch Esp Urol 2019 Oct;72(8):772-785

Servicio de Urología. Hospital Universitario Puerta de Hierro de Majadahonda. Madrid. España.

Objectives: Systematic review of the treatment of small testicular masses (STM) by testicular sparing surgery (TSS), including indications, surgical techniques and complications, as well as the correlation of the analysis of frozen sections (FSE) with the final tumor histology. As a secondary objective we report the initial experience of our center in TSS.

Material And Methods: A systematic literature search of the Medline/PubMed database for studies published until June 30, 2019 with the following keywords: "testis sparing surgery", "conservative surgery", "partial orquiectomy" "testicular neoplasms", "testis tumour", "Sex cord tumor", "intraoperative ultrasonography", "enucleation", "excision" or "resection" without time limits, in English and Spanish, identifying 20 articles with a total of 204 TSS, being the series with the largest sample size of 28. Read More

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October 2019
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Testis-sparing Surgery for Pediatric Leydig Cell Tumors: Evidence of Favorable Outcomes Irrespective of Surgical Margins.

Urology 2019 Dec 24;134:203-208. Epub 2019 Sep 24.

Division of Urology, Department of Surgery, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada. Electronic address:

Objective: To review our single institution experience, exploring the role of testis-sparing surgical resection in a cohort of children with Testicular Leydig cell tumors (LCTs).

Materials And Methods: We reviewed all consecutive children presenting with testicular tumors between 2003 and 2017 (n = 66), excluding patients with alternative pathologies (n = 57). Subsequently data were collected on age at surgery, laterality, type of surgery, operative time, presenting symptoms, serum markers, imaging findings, frozen section, final pathology, and follow-up. Read More

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http://dx.doi.org/10.1016/j.urology.2019.09.016DOI Listing
December 2019
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Playing the long surveillance ball game: Metachronous testicular tumor developing after treatment and remission of extragonadal germ cell tumor.

Rare Tumors 2019 9;11:2036361319873196. Epub 2019 Sep 9.

Rush University Medical Center, Chicago, IL, USA.

A 32-year-old man with vague abdominal pain was found to have enlarged para-aortic and mediastinal lymph nodes on computed tomography. He was diagnosed with retroperitoneal mixed germ cell tumor as confirmed on percutaneous biopsy. At the time of diagnosis, lactic dehydrogenase, human beta-chorionic gonadotropin, and alpha-fetoprotein were elevated. Read More

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http://dx.doi.org/10.1177/2036361319873196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734599PMC
September 2019
3 Reads

Surgical treatment of testicular tumor and its difficult management with indigenous patient.

AME Case Rep 2019 19;3:23. Epub 2019 Jul 19.

Urology Department, Federal University of Amazonas (UFAM), Manaus, Amazonas, Brazil.

Case description of a male patient, 27 years old, native Brazilian, indigenous, deaf, with a significant growth of left testicle, painless, with infiltrations, insidious beginning and two years of evolution because of the difficulty of monitoring this type of population. Presented high serum level of lactate dehydrogenase (LDH), up to 20 times higher than the maximum reference value. Ultrasound of the testis showed a complex mass on the left testicle, not being able to give an estimate of the volume. Read More

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http://dx.doi.org/10.21037/acr.2019.07.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691055PMC
July 2019
3 Reads

Robot-assisted laparoscopic retroperitoneal lymph node dissection with concomitant inferior vena cava thrombectomy for metastatic mixed testicular germ cell cancer: a case report.

J Med Case Rep 2019 Aug 27;13(1):272. Epub 2019 Aug 27.

Department of Urology, Beijing United Family Hospital and Clinics, Beijing, 100015, China.

Background: The robot-assisted laparoscopic management of post-chemotherapy retroperitoneal metastasis and inferior vena cava tumor thrombus secondary to testicular cancer is a challenging task for urologists.

Case Presentation: A pathological examination of a 36-year-old Caucasian man who had undergone a right radical orchiectomy showed mixed testicular germ cell cancer (70% embryonal cancer and 30% seminoma); he had undergone four prior courses of cisplatin, etoposide, and bleomycin chemotherapy and was found to have residual retroperitoneal enlarged lymph nodes close to the right renal hilum and a 9.8 cm inferior vena cava tumor thrombus (pT1, N2, M1, S2). Read More

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http://dx.doi.org/10.1186/s13256-019-2200-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710881PMC
August 2019
6 Reads

Isolated biopsy-proven recurrence of prostate carcinoma in the spermatic cord after radical prostatectomy detected with 11C-Choline PET/CT.

Urol Case Rep 2019 Sep 31;26:100985. Epub 2019 Jul 31.

Department of Radiation Oncology, Mayo Clinic, Rochester, MN, 200 First Street SW, Rochester, MN, 55905, USA.

We report an unusual case of a solitary prostatic metastasis in the spermatic cord, following robotic-assisted laparoscopic radical prostatectomy with pelvic lymph node dissection and salvage radiotherapy, detected with the use of C-Choline PET/CT, heralded by a progressive rise in PSA. This lesion was biopsy-proven and surgically resected through radical left-sided orchiectomy. Postoperatively his PSA was undetectable and remained undetectable with no evidence of recurrent disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22144420193028
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http://dx.doi.org/10.1016/j.eucr.2019.100985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685691PMC
September 2019
3 Reads