510 results match your criteria Orchiectomy Partial

Poorly Differentiated Neuroendocrine Carcinoma of Unknown Primary with Metastasis to the Testis: A Case Report.

Case Rep Oncol 2022 Jan-Apr;15(1):388-393. Epub 2022 Apr 8.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Neuroendocrine neoplasms are rare epithelial neoplasms with neuroendocrine differentiation. Few cases of primary testicular poorly differentiated neuroendocrine carcinomas (PD-NECs) have been reported, and secondary testicular neoplasms are rare. A 61-year-old man with a chief complaint of left testicular swelling was referred to our hospital. Read More

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Segmental testicular infarction: A case report of a rare condition.

Urol Case Rep 2022 Jul 13;43:102115. Epub 2022 May 13.

University of Tunis El Manar, Faculty of Medicine of Tunis, Charles Nicolle Hospital, Urology Department, Tunis, Tunisia.

Segmental testicular infarction(STI) is a rare unknown condition. Clinical presentation is non-specific and management is unconsensual. We report clinical and surgical management of a segmental testicular infarction. Read More

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Predicting malignancy in small testicular lesions.

Cent European J Urol 2022 22;75(1):47-51. Epub 2022 Feb 22.

Department of Urology, Pontificate Catholic University, Santiago, Chile.

Introduction: Small testicular lesions ≤20 mm (STL) detected by ultrasound (US), usually non-palpable, have been reported to be benign in up to 80% of cases. Thus, partial orchiectomy with or without frozen section examination and surveillance has been advocated for these kinds of lesions. We seek to report the proportion of benign lesions in testicular tumors ≤20 mm detected by US in our population and explore the predicting factors of malignancy. Read More

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February 2022

Splenogonadal fusion presenting as a testicular mass, a case report and literature review.

Radiol Case Rep 2022 Jun 19;17(6):2191-2194. Epub 2022 Apr 19.

Department of Radiology, SUNY Upstate Medical University, Rm. 3428, 750 East Adams Street, Syracuse, NY 13210, USA.

Splenogonadal fusion is a rare, frequently misdiagnosed, congenital anomaly in which the splenic tissue is abnormally attached to the gonadal or mesonephric remnants. It is commonly found as an incidental finding at autopsy, during orchiopexy or hernia repair. However, it can present as a testicular mass or as an acute scrotal pathology such as testicular torsion or epididymoorchitis. Read More

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Targeting the androgen receptor signaling pathway in advanced prostate cancer.

Am J Health Syst Pharm 2022 Apr 7. Epub 2022 Apr 7.

Houston Methodist Hospital, Houston, TX, USA.

Disclaimer: In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Read More

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Yolk Sac Tumor in an Infant with Androgen Insensitivity Syndrome: A Case Report and Review of the Literature.

Int J Surg Pathol 2022 Mar 7:10668969221085292. Epub 2022 Mar 7.

159442Hangzhou Children's Hospital, Hangzhou, China.

Androgen insensitivity syndrome (AIS) is a disorder of sexual differentiation caused by complete or partial resistance to the biological action of androgens. The common malignant tumors associated with this syndrome are seminomas. However, the risk of malignancy in childhood remains low. Read More

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Promising Immunotherapy in Metastatic Testicular Sex Cord Stromal Tumours After First-Line Chemotherapy.

Front Immunol 2021 10;12:720359. Epub 2022 Jan 10.

Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Testicular sex cord stromal tumours (TSCSTs) are rare, with few studies focusing on the metastatic TSCST prognosis. The value of treatments, including radical orchiectomy (RO) and retroperitoneal lymph node dissection (RPLND), in preventing metastasis is controversial. Additionally, metastatic TSCSTs are resistant to chemotherapy. Read More

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February 2022

Atypical Presentation of Testicular Adrenal Rest Tumor (TART) Leading to Bilateral Partial Orchiectomy in a 31-Year-Old Adult Revealing Primary Adrenal Insufficiency with Deficiency.

Case Rep Endocrinol 2021 23;2021:5889007. Epub 2021 Dec 23.

Hôpital d'Instruction des Armées BEGIN, Service d'endocrinologie, 69 avenue de Paris, Saint-Mande 94160, France.

Adrenogenital syndrome is commonly associated with a deficiency in 21-hydroxylase but can be present in other rare enzymatic blocks. We report here the case of a 31-year-old man who presented with bilateral painful testicle lesions leading to bilateral partial orchiectomy as they were suspected for malignancy. These lesions were finally identified as benign testicle adrenal rest tumors (TARTs), and the patient was actually belatedly diagnosed with primary adrenal insufficiency due to 2 mutations of the gene encoding the cholesterol side-chain cleavage enzyme (P450scc); the mutations were 940G > A (p. Read More

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December 2021

Metachronous Bilateral Testicular Plasmacytoma After an Initial Soft Tissue, Extramedullary Plasmacytoma.

Cureus 2021 Nov 12;13(11):e19517. Epub 2021 Nov 12.

Second Department of Urology, National and Kapodistrian University of Athens, Sismanogleio General Hospital, Athens, GRC.

Testicular plasmacytoma is a rare extramedullary manifestation of plasma cell dyscrasia. We report a case of a 53-year-old man who presented with a metachronous testicular lesion originating from a soft tissue plasmacytoma of the oral cavity. He underwent radical orchiectomy and a year later, presented with testicular plasmacytoma in the contralateral testis. Read More

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November 2021

Additive effects of orchiectomy and intermittent hypoxia on lung mechanics and inflammation in C57BL/6J male mice.

Exp Physiol 2022 01 23;107(1):68-81. Epub 2021 Nov 23.

Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie du Québec, Université Laval, Québec, QC, Canada.

New Findings: What is the central question of this study? Does endogenous testosterone modulate the consequences of intermittent hypoxia (IH) in the lungs of male mice? What is the main finding and its importance? Orchiectomized mice exposed to IH develop a pattern that is similar to emphysema or obstructive lung disease with elevated lung volumes, low pulmonary elastance during a methacholine challenge test and high counts of lymphocytes in bronchoalveolar lavages. Since low testosterone levels and other respiratory diseases are common in sleep apnoea, there is a clear clinical relevance to these results.

Abstract: We tested the hypothesis that low testosterone levels modulate the pulmonary responses to intermittent hypoxia (IH; used as a model of sleep apnoea (SA)) in male mice. Read More

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January 2022

First report of testis-sparing surgery for sertoliform cystadenoma: case presentation and review of literature.

IJU Case Rep 2021 Nov 7;4(6):425-428. Epub 2021 Sep 7.

Department of Urology La Croix du Sud Hospital Quint Fonsegrives France.

Introduction: Sertoliform cystadenoma is a very rare, benign lesion of the rete-testis difficult to distinguish from other malignancies of the testicle.

Case Presentation: We present the case of a 42-year-old male who presented with a right testicular mass, asymptomatic for 1 year. Clinical examination revealed a palpable, painless, and well-delimited right testicular superior pole nodule. Read More

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November 2021

'Burned-Out' primary testicular tumour: Is retroperitoneal lymph node biopsy mandatory prior to initiation of chemotherapy? Report of three cases and a review of the literature.

Andrologia 2022 Mar 21;54(2):e14283. Epub 2021 Oct 21.

Institute for Oncology, Clinical Centre of Montenegro, Podgorica, Montenegro.

The term 'burned-out' tumour of the testis describes a spontaneously and completely regressed testicular tumour that presents at the stage of metastasis. We report three cases of burned-out testicular tumour to illustrate their clinical, radiological and histopathological features and to discuss the hypothesis of the efficacy of early adjuvant chemotherapy without a previous retroperitoneal lymph node biopsy. Subsequent to radical orchiectomy, each pathohistology report revealed testicular hypotrophy or microcalcifications, with no clearly visible germ cell tumours within the specimen. Read More

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[Successful Management for Refractory Non-Seminomatous Testicular Cancer with Retroperitoneal Lymph Node, Liver, Lung and Brain Metastases : A Case Report].

Hinyokika Kiyo 2021 Sep;67(9):433-437

The Department of Urology, Kumamoto University, School of Medicine.

An 18-year-old male was aware of painless left testicular enlargement. Contrast-enhanced computed tomography showed a retroperitoneal tumor, multiple liver tumors, and multiple lung tumors. A left testicular tumor was suspected, and left inguinal orchiectomy was performed. Read More

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September 2021

COVID-19 pandemic impact on uro-oncological disease outcomes at an Italian tertiary referral center.

World J Urol 2022 Jan 25;40(1):263-269. Epub 2021 Sep 25.

Division of Urology, Department of Surgical Sciences - Urology, Città della Salute e della Scienza di Torino - Molinette Hospital, University of Turin, Turin, Italy.

Purpose: To assess differences in referral and pathologic outcomes for uro-oncology cases prior to and during the COVID pandemic, comparing clinical and pathological data of cancer surgeries performed at an academic referral center between 2019 and 2020.

Methods: We collected data of 880 prostate biopsies, 393 robot-assisted radical prostatectomies (RARP) for prostate cancer (PCa), 767 trans-urethral resections of bladder tumor (TURB) and 134 radical cystectomies (RC) for bladder cancer (BCa), 29 radical nephro-ureterectomies (RNU) for upper tract urothelial carcinoma, 130 partial nephrectomies (PN) and 12 radical nephrectomies (RN) for renal cancer, and 41 orchifunicolectomies for testicular cancer. Data of patients treated in 2019 (before COVID-19 pandemic) were compared to patients treated in 2020 (during pandemic). Read More

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January 2022

EAU-ESPU pediatric urology guidelines on testicular tumors in prepubertal boys.

J Pediatr Urol 2021 08 9;17(4):529-533. Epub 2021 Jun 9.

Department of Urology, University of Leuven, Leuven, Belgium.

Background: Testicular tumors in prepubertal boys account for 1-2% of all solid pediatric tumors. They have a lower incidence, a different histologic distribution and are more often benign compared to testicular tumors in the adolescent and adult group. This fundamental difference should also lead to a different approach and treatment. Read More

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Prolactin promotes a partial recovery from the atrophy of both male and female gerbil prostates caused by castration.

Reprod Biol Endocrinol 2021 Jun 22;19(1):94. Epub 2021 Jun 22.

Department of Structural and Functional Biology, Institute of Biology, State University of Campinas - UNICAMP, SP, Campinas, Brazil.

Background: The male and female prostates are controlled by steroid hormones, suffering important morphological and physiological changes after castration. Prolactin is involved in the regulation of the male prostate, having already been identified in the tissue, acting through its receptor PRLR. In the Mongolian gerbil, in addition to the male prostate, the female prostate is also well developed and active in its secretion processes. Read More

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Intraoperative pathology consultation during urological surgery: Impact on final margin status and pitfalls of frozen section diagnosis.

Hiroshi Miyamoto

Pathol Int 2021 Sep 21;71(9):567-580. Epub 2021 Jun 21.

Departments of Pathology & Laboratory Medicine and Urology, University of Rochester Medical Center, Rochester, New York, USA.

Despite recent improvements in diagnostic and surgical techniques in urological oncology, positive resection margin remains a significant concern for surgeons. Meanwhile, intraoperative pathology consultation with frozen section assessment (FSA), particularly for histological diagnosis of the lesions incidentally found or enlarged or sentinel lymph nodes, generally provides critical information which enables immediate decision making for optimal patient care. The intraoperative evaluation of surgical margins is also often requested, although there are some differences in its application between institutions and surgeons. Read More

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September 2021

Residual antler periosteum holds the potential to partially regenerate lost antler tissue.

Chunyi Li

J Exp Zool A Ecol Integr Physiol 2021 04 1;335(4):386-395. Epub 2021 Apr 1.

Institute of Antler Science and Product Technology, Changchun Sci-Tech University, Changchun City, Jilin Province, China.

Deer antlers are the only mammalian organs that can fully regenerate, which relies on pedicle periosteum (PP). Interestingly during the growing phase, antlers themselves can regenerate partially lost antler tissue. However, what tissue type in the growing antlers fulfills this role is not known. Read More

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Retroperitoneal extension of massive ulcerated testicular seminoma through the inguinal canal: A case report.

Arch Ital Urol Androl 2021 Mar 19;93(1):64-67. Epub 2021 Mar 19.

Department of Medical, Oral and Biotechnological Sciences, G. d'Annunzio University of Chieti, Urology Unit, SS. Annunziata Hospital, Chieti.

Introduction: Testicular cancers represent about 5% of all urological malignancies and 1-1.5% of all male neoplasms. Most of the testicular cancers are localized (68%) at diagnosis. Read More

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Radiotherapy after testis-sparing surgery for seminoma in monorchid patients: safety and efficacy.

Tumori 2022 Apr 15;108(2):165-171. Epub 2021 Feb 15.

Urology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Purpose: To evaluate local control and longitudinal endocrine data in monorchid patients treated with testicular-sparing surgery and adjuvant radiotherapy (RT) for seminomatous germ-cell tumors.

Methods: We searched our database established in 2009 for patients with seminoma who received testis irradiation following partial orchiectomy up to 2018. Eleven patients were identified. Read More

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Incidental ectopic adrenal cortical tissue: Retrospective analysis of 16 patients.

J Pediatr Urol 2021 04 16;17(2):258.e1-258.e6. Epub 2021 Jan 16.

Konya Training and Research Hospital, Urology, Pediatric Urology, Konya, Turkey. Electronic address:

Objective: To evaluate ectopic adrenal cortical tissue (EACT) and identify clinical, pathological and radiological aspects.

Study Design: Retrospective review of pathology reports in a single tertiary institution between 2010 and 2020 was conducted. Patients diagnosed with EACT were included for analysis. Read More

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Partial orchiectomy radical orchiectomy for pediatric testis tumors.

Transl Androl Urol 2020 Oct;9(5):2400-2407

Department of Urology, Rush University Medical Center, Chicago, IL, USA.

While radical orchiectomy remains the gold standard for testicular cancer, partial orchiectomy has become a well-accepted organ-sparing approach for benign testicular tumors in pre-pubertal patients. The aims of testicular-sparing surgery include prevention of over-treatment, preservation of future hormonal and reproductive function, and provision of a durable cure. For pre-pubertal patients, who have a high likelihood of benign lesions, partial orchiectomy provides effective treatment, owing to the high reliability of scrotal ultrasound (US) and intraoperative frozen section. Read More

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October 2020

Case Report: An extremely rare occurrence of recurrent inguinal low-grade fibromyxoid sarcoma involving the scrotum.

F1000Res 2020 29;9:789. Epub 2020 Jul 29.

Urology, Fluminense Federal University, Niterói, Rio de Janeiro, 24220900, Brazil.

Low-grade fibromyxoid sarcoma (LGFMS) is a rare sarcoma subtype. The most common tumor locations are the deep soft tissue of extremities or trunks. We report a rare case of recurrent LGFMS in the inguinal region involving the scrotum and both testicles. Read More

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SRY-Positive 46, XX Testicular Disorder of Sexual Development With Leydig Cell Tumor.

Am J Mens Health 2020 Sep-Oct;14(5):1557988320970071

Department of Urology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Saitama, Japan.

The risk of a gonadal tumor is high in testicular disorder of sexual development (DSD) with the Y chromosome, but cases of DSD without the Y chromosome are extremely rare. We reported a gonadal tumor in a phenotypically male individual with 46, XX testicular DSD. A testicular tumor was incidentally found in a 32-year-old phenotypic male who was presented to the hospital with male infertility. Read More

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October 2021

Real-World Application of Pre-Orchiectomy miR-371a-3p Test in Testicular Germ Cell Tumor Management.

J Urol 2021 Jan 28;205(1):137-144. Epub 2020 Aug 28.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas.

Purpose: Current serum tumor markers for testicular germ cell tumor are limited by low sensitivity. Growing evidence supports the use of circulating miR-371a-3p as a superior marker for malignant (viable) germ cell tumor management. We evaluated the real-world application of serum miR-371a-3p levels in detecting viable germ cell tumor among patients undergoing partial or radical orchiectomy. Read More

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January 2021

Transverse testicular ectopia: two rare adult cases and a review of literature.

BMJ Case Rep 2020 May 6;13(5). Epub 2020 May 6.

Urology, Kasturba Medical College, Manipal, Manipal University, Manipal, Karnataka, India.

The first case is a 45-year-old man who presented with complaints of right-sided indirect hernia. On examination the left hemiscrotum was empty. Open hernioplasty and mesh fixation with orchiopexy of both testes were done in the same hemiscrotum, followed by MRI for further evaluation. Read More

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Partial orchiectomy: The Princess Margaret cancer centre experience.

Urol Oncol 2020 06 10;38(6):605.e19-605.e24. Epub 2020 Apr 10.

Division of Urology, Department of Surgery, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, ON, Canada. Electronic address:

Introduction: Radical orchiectomy (RO) is the standard treatment for a testis cancer. Organ sparing surgery can be considered in the setting of a solitary functioning testis or bilateral tumors. It has also been suggested as an alternative to RO for small lesions. Read More

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Large Cell Calcifying Sertoli Cell Tumor with Macrocalcification in a Partially Resected Testis.

Case Rep Pathol 2020 18;2020:5279013. Epub 2020 Mar 18.

Department of Pathology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Large cell calcifying Sertoli cell tumors (LCCSCTs) are extremely rare, with less than 100 tumors being described to date. Most of the tumors are benign with a few malignant cases, and aggressive behavior is infrequent. These tumors are a type of Sertoli cell tumor, and these tumors comprise less than 0. Read More

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Metastatic Renal Cell Carcinoma to the Testis: A Clinicopathologic Analysis of Five Cases.

Case Rep Pathol 2020 2;2020:9394680. Epub 2020 Mar 2.

Department of Pathology, Vancouver General Hospital, Vancouver, BC, Canada.

The testicular spread of renal cell carcinoma is extremely rare. Five cases of renal cell carcinoma metastatic to the testis are described. The patients ranged from 45 to 81 years of age. Read More

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The role of partial orchidectomy in the management of small testicular tumours: Fertility and endocrine function.

Andrology 2020 09 22;8(5):988-995. Epub 2020 Jun 22.

MRC Centre for Transplantation, Guy's Hospital Campus, King's College London, London, UK.

Background: Radical orchidectomy in patients who are subsequently diagnosed with benign testicular tumours represents an overtreatment due to the deleterious effects on endogenous testosterone, fertility and body image. For these reasons, the option of partial orchidectomy (PO) should be considered in certain groups of patients. Patients with bilateral tumours (synchronous or metachronous) or a solitary testis where the lesion is no greater than 30% of the volume of the testis could be considered for a PO. Read More

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September 2020