2,663 results match your criteria Orbivirus


Bluetongue virus VP6 and genomic RNA interaction is essential for genome packaging.

J Virol 2018 Dec 12. Epub 2018 Dec 12.

Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom

The genomes of the , including the animal pathogen Bluetongue virus (BTV), are multi-segmented double-stranded (ds) RNA. During replication, single-stranded (ss) positive-sense RNA segments are packaged into the assembling virus capsid, triggering genomic dsRNA synthesis. However, exactly how this packaging event occurs is not clear. Read More

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December 2018

Isolation and Genome Phylogenetic Analysis of Arthropod-Borne Viruses, Including Akabane Virus, from Mosquitoes Collected in Hunan Province, China.

Vector Borne Zoonotic Dis 2018 Dec 11. Epub 2018 Dec 11.

1 State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention , Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China .

This study investigated the abundance of mosquitoes and circulation of mosquito-borne arboviruses from 16 villages in 8 cities of Hunan Province, China, in July-August of 2010 and in August of 2011. In total, 16,076 mosquitoes consisting of seven species from four genera were collected by ultraviolet-light trap. Culex quinquefasciatus was the most common species, accounting for 50. Read More

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December 2018
1 Read

Amino acid starvation accelerates replication of Ibaraki virus.

Virus Res 2018 Nov 29;260:94-101. Epub 2018 Nov 29.

Laboratory of Veterinary Hygiene, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1, Yoshida, Yamaguchi, 753-8515, Japan. Electronic address:

Ibaraki virus (IBAV) is a strain of epizootic hemorrhagic disease virus 2 that belongs to the genus Orbivirus of the family Reoviridae. IBAV replication is suppressed by the inhibition of autophagy, and since mechanistic target of rapamycin complex 1 (mTORC1) is a key regulator of autophagy, we examined if mTORC1 inhibition by amino acid starvation or mTOR inhibitors (Torin 1 and rapamycin) affects IBAV replication. We found that IBAV replication is significantly enhanced after amino acid starvation of host cells, but not after treatment with mTOR inhibitors, during early stages of viral infection (0-1 hpi). Read More

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November 2018
4 Reads

Chuzan Virus in Yaks, Qinghai-Tibetan Plateau, China.

Emerg Infect Dis 2018 Dec;24(12):2371-2373

We detected Chuzan virus (CHUV) in domestic yaks from the Qinghai-Tibetan Plateau, western China, indicating CHUV probably has been transmitted to yaks in recent years. Awareness for CHUV surveillance and transmission and livestock health management in these special regions should be raised to avoid outbreaks and animal loss. Read More

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December 2018
6 Reads
6.751 Impact Factor

The first report on serotyping of bluetongue virus in small ruminants of Khyber Pakhtunkhwa province, Pakistan.

Trop Anim Health Prod 2018 Nov 7. Epub 2018 Nov 7.

University College of Veterinary and Animal Sciences, Islamia University of Bahawalpur Pakistan, Bahawalpur, Pakistan.

Bluetongue virus (BTV), a member of Orbivirus genus (family Reoviridae), is a non-contagious infection of domestic and wild ruminants. The current study was designed to detect various serotypes of BTV in small ruminants of Khyber Pakhtunkhwa (KPK) province of Pakistan, along with their effects on hemato-biochemical parameters. A total of 408 serum samples in four districts (Mansehra, Abbottabad, Swabi, and Kohat) of KPK from small ruminants were screened based on competitive ELISA (cELISA). Read More

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November 2018

Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses.

Vet Res 2018 Oct 11;49(1):105. Epub 2018 Oct 11.

Biopharming Research Unit, Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, Cape Town, 7701, South Africa.

African horse sickness (AHS) is caused by multiple serotypes of the dsRNA AHSV and is a major scourge of domestic equids in Africa. While there are well established commercial live attenuated vaccines produced in South Africa, risks associated with these have encouraged attempts to develop new and safer recombinant vaccines. Previously, we reported on the immunogenicity of a plant-produced AHS serotype 5 virus-like particle (VLP) vaccine, which stimulated high titres of AHS serotype 5-specific neutralizing antibodies in guinea pigs. Read More

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October 2018
3 Reads

Longitudinal monitoring of Culicoides in Belgium between 2007 and 2011: local variation in population dynamics parameters warrant cautious use of monitoring data.

Parasit Vectors 2018 Sep 17;11(1):512. Epub 2018 Sep 17.

Enzootic, vector-borne and bee diseases, Sciensano, Brussels, Belgium.

Background: Several European countries suffered important economic losses during the past decade due to the emergence of bluetongue and Schmallenberg viruses. Both are viruses of veterinary importance and are spread by Culicoides spp. This triggered many European countries to start Culicoides population monitoring. Read More

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September 2018
11 Reads

Molecular and serological surveillance of African horse sickness virus in eastern and central Saudi Arabia.

Rev Sci Tech 2017 Dec;36(3):889-898

African horse sickness virus (AHSV) is one of the most devastating viral diseases of the family Equidae. Infection with AHSV threatens not only the Saudi equine industry but also the equine industry worldwide. This is due to the high morbidity and mortality rates among the infected population of up to 100%. Read More

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December 2017
1 Read

The role of climate change in a developing threat: the case of bluetongue in Europe.

Rev Sci Tech 2017 Aug;36(2):467-478

There is a solid theoretical basis for expecting climate change to have a considerable effect on the infectious diseases of humans, animals and plants. Vector-borne diseases are the most likely to be affected. It is, however, rare to observe such impacts, as diseases are also influenced by many other drivers, some of which may have stronger effects over shorter time scales than climate change. Read More

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The genome of the biting midge Culicoides sonorensis and gene expression analyses of vector competence for bluetongue virus.

BMC Genomics 2018 Aug 22;19(1):624. Epub 2018 Aug 22.

The Pirbright Institute, Ash Road, Woking, Surrey, GU24 0NF, UK.

Background: The new genomic technologies have provided novel insights into the genetics of interactions between vectors, viruses and hosts, which are leading to advances in the control of arboviruses of medical importance. However, the development of tools and resources available for vectors of non-zoonotic arboviruses remains neglected. Biting midges of the genus Culicoides transmit some of the most important arboviruses of wildlife and livestock worldwide, with a global impact on economic productivity, health and welfare. Read More

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August 2018
3 Reads

Vector competence of pre-alpine Culicoides (Diptera: Ceratopogonidae) for bluetongue virus serotypes 1, 4 and 8.

Parasit Vectors 2018 Aug 13;11(1):466. Epub 2018 Aug 13.

National Centre for Vector Entomology, Institute of Parasitology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.

Background: Bluetongue disease, caused by bluetongue virus serotype 8 (BTV-8), appeared for the first time in the northern part of Europe in 2006, and subsequently rapidly spread causing severe economic losses to the farming industry. The implicated vectors of BTV in Europe are Culicoides species within the subgenus Avaritia (C. chiopterus, C. Read More

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Full genome sequence of a Sathuvachari virus strain isolated in the southwestern-most archipelago of Japan.

Virus Genes 2018 Oct 1;54(5):729-732. Epub 2018 Aug 1.

Kyushu Research Station, National Institute of Animal Health, NARO, 2702, Chuzan, Kagoshima, Kagoshima, Japan.

Two virus strains, tentatively designated as ON-6/P/05 and ON-7/E/05, were isolated from blood samples of healthy cattle in the Yaeyama Islands, located in the southwestern-most region of Japan, in 2005. Ultrastructural observations of infected baby hamster (BHK-21) cells revealed that the viruses had features consistent with those of orbivirus. As with other orbiviruses, the viral genome consists of 10 double-stranded RNA segments. Read More

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October 2018
12 Reads

Sero-epidemioloical survey on African horse sickness virus among horses in Khartoum State, Central Sudan.

BMC Vet Res 2018 Aug 1;14(1):230. Epub 2018 Aug 1.

Molecular Biology Laboratory (MBL), Department of Clinical Medicine, Faculty of Veterinary Medicine, University of Khartoum, P.O. Box 32, Khartoum North, Sudan.

Background: African horse sickness virus (AHSV) is an infectious non contagious insect-transmitted double-stranded (ds) RNA orbivirus of the family Reoviridae. AHSV causes an often fatal hemorrhagic infection with high mortality among selected breeds of Arabian horses. This study was conducted to avail some information with regard to the prevalence and associated risk factors of AHSV among ecotype breeds of horses in central Sudan. Read More

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August 2018
5 Reads

Comparative Neuropathology of Major Indian Bluetongue Virus Serotypes in a Neonatal BALB/c Mouse Model.

J Comp Pathol 2018 Jul 3;162:18-28. Epub 2018 Jul 3.

School of Veterinary Medicine and Science, The University of Nottingham, UK.

Bluetongue virus (BTV) is neurotropic in nature, especially in ruminant fetuses and in-utero infection results in abortion and congenital brain malformations. The aim of the present study was to compare the neuropathogenicity of major Indian BTV serotypes 1, 2, 10, 16 and 23 by gross and histopathological lesions and virus distribution in experimentally infected neonatal BALB/c mice. Each BTV serotype (20 μl of inoculum containing 1 × 10 tissue culture infectious dose [TCID]/ml of virus) was inoculated intracerebrally into 3-day-old mice, while a control group was inoculated with mock-infected cell culture medium. Read More

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July 2018
11 Reads

Assessment of cross-protection induced by a bluetongue virus (BTV) serotype 8 vaccine towards other BTV serotypes in experimental conditions.

Vet Res 2018 07 16;49(1):63. Epub 2018 Jul 16.

Faculty of Veterinary Medicine, Research Unit in Epidemiology and Risk Analysis Applied to Veterinary Sciences (UREAR-ULg), Fundamental and Applied Research for Animal and Health (FARAH) Center, University of Liege, Liege, Belgium.

Bluetongue disease is caused by bluetongue virus (BTV) and BTV serotype 8 (BTV8) caused great economic damage in Europe during the last decade. From 1998 to 2007, in addition to BTV8, Europe had to face the emergence of BTV1, 2, 4, 9, and 16, spreading in countries where the virus has never been detected before. These unprecedented outbreaks trigger the need to evaluate and compare the clinical, virological and serological features of the European BTV serotypes in the local epidemiological context. Read More

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July 2018
7 Reads

Identification and characterization of novel mosquito-borne (Kammavanpettai virus) and tick-borne (Wad Medani) reoviruses isolated in India.

J Gen Virol 2018 Aug 25;99(8):991-1000. Epub 2018 Jun 25.

1​Maximum Containment Laboratory, National Institute of Virology, Pune, Maharashtra, India.

In 1954, a virus named Wad Medani virus (WMV) was isolated from Hyalomma marginatum ticks from Maharashtra State, India. In 1963, another virus was isolated from Sturnia pagodarum birds in Tamil Nadu, India, and named Kammavanpettai virus (KVPTV) based on the site of its isolation. Originally these virus isolates could not be identified with conventional methods. Read More

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August 2018
1 Read
3.183 Impact Factor

A possible role for domestic dogs in the spread of African horse sickness virus.

Authors:
Chris Oura

Vet Rec 2018 06;182(25):713-714

School of Veterinary Medicine, Faculty of Medical Sciences, University of the West Indies,Trinidad and Tobago.

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June 2018
1 Read

Physiological and immunological responses to Culicoides sonorensis blood-feeding: a murine model.

Parasit Vectors 2018 Jun 20;11(1):358. Epub 2018 Jun 20.

Arthropod-Borne Animal Diseases Research Unit, Agricultural Research Service, US Department of Agriculture, Manhattan, KS, 66502, USA.

Background: Hematophagous Culicoides spp. biting midges are of great agricultural importance as livestock, equine, and wildlife pests and as vectors of the orbiviruses bluetongue, epizootic hemorrhagic disease and African horse sickness. To obtain a blood meal, midges deposit saliva containing allergens, proteases, and anti-hemostatic factors, into the dermis to facilitate feeding. Read More

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June 2018
1 Read

Bluetongue transmission and control in Europe: A systematic review of compartmental mathematical models.

Prev Vet Med 2018 Aug 24;156:113-125. Epub 2018 May 24.

Epidemiology Unit, Laboratory for Animal Health, French Agency for Food, Environmental and Occupational Health and Safety (ANSES), University Paris-Est, 14 rue Pierre et Marie Curie, Maisons-Alfort, 94700, France. Electronic address:

The growing frequency of bluetongue virus (BTV) incursions in Europe in recent years led to the largest BTV outbreak ever recorded in 2006/09, with a dramatic impact on the cattle and sheep industries. The complex epidemiology of this vector-borne disease of ruminants and its recent emergence need to be better understood to identify and implement efficient control strategies. Mathematical models provide useful tools for that purpose; many of them have been developed in the light of the 2006/09 outbreak. Read More

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August 2018
2 Reads

Emergence of bluetongue virus serotype 4 in mainland France in November 2017.

Transbound Emerg Dis 2018 Oct 8;65(5):1158-1162. Epub 2018 Jun 8.

UMR 1161 ANSES/INRA/ENVA, Université Paris-Est ANSES Maisons-Alfort, Maisons-Alfort, France.

In November 2017, a 15-day-old calf located in France (Haute-Savoie department) was found positive for bluetongue virus (BTV) RNA by RT-PCR. Laboratory investigations allowed the isolation and identification of the serotype: BTV-4. The analysis of the full viral genome showed that all the 10 genome segments were closely related to BTV-4 strains involved in a large BT outbreak in the Balkan Peninsula, in Italy since 2014 and in Corsica since the end of October 2016. Read More

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October 2018
9 Reads

Spatial distribution modelling of Culicoides (Diptera: Ceratopogonidae) biting midges, potential vectors of African horse sickness and bluetongue viruses in Senegal.

Parasit Vectors 2018 Jun 8;11(1):341. Epub 2018 Jun 8.

CIRAD, ASTRE, Montpellier, France.

Background: In Senegal, the last epidemic of African horse sickness (AHS) occurred in 2007. The western part of the country (the Niayes area) concentrates modern farms with exotic horses of high value and was highly affected during the 2007 outbreak that has started in the area. Several studies were initiated in the Niayes area in order to better characterize Culicoides diversity, ecology and the impact of environmental and climatic data on dynamics of proven and suspected vectors. Read More

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June 2018
3 Reads

CD8 T Cell Responses to an Immunodominant Epitope within the Nonstructural Protein NS1 Provide Wide Immunoprotection against Bluetongue Virus in IFNAR Mice.

J Virol 2018 08 31;92(16). Epub 2018 Jul 31.

Center for Animal Health Research, INIA-CISA, Valdeolmos, Madrid, Spain

The development of vaccines against bluetongue, a prevalent livestock disease, has been focused on surface antigens that induce strong neutralizing antibody responses. Because of their antigenic variability, these vaccines are usually serotype restricted. We now show that a single highly conserved nonstructural protein, NS1, expressed in a modified vaccinia Ankara virus (MVA) vector can provide multiserotype protection in IFNAR 129 mice against bluetongue virus (BTV) that is largely dependent on CD8 T cell responses. Read More

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August 2018
8 Reads

Retrospective analysis of Bluetongue farm risk profile definition, based on biology, farm management practices and climatic data.

Prev Vet Med 2018 Jul 12;155:75-85. Epub 2018 Apr 12.

Istituto Zooprofilattico Sperimentale della Sardegna "G. Pegreffi" - Centro di Sorveglianza Epidemiologica, Via XX Settembre n°9, 09125, Cagliari, CA, Italy.

Bluetongue (BT) is a vector-borne disease transmitted by species of Culicoides midges (Diptera: Ceratopogonidae). Many studies have contributed to clarifying various aspects of its aetiology, epidemiology and vector dynamic; however, BT remains a disease of epidemiological and economic importance that affects ruminants worldwide. Since 2000, the Sardinia region has been the most affected area of the Mediterranean basin. Read More

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July 2018
1 Read

Evaluation of the immune response afforded by a subunit vaccine candidate against bluetongue virus in mice and sheep.

Vet Microbiol 2018 Jun 5;219:40-48. Epub 2018 Apr 5.

State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou, Gansu, 730046, PR China; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, PR China. Electronic address:

Bluetongue virus (BTV), a vector-borne pathogen, is the causative agent of bluetongue disease in ruminants. In view of the recent emergence of BTV in regions previously known to be free from the disease and/or specific serotypes or strains, optimization of the currently available vaccination strategies to control the spread of vector-borne bluetongue is crucial. The main objective of the current study was to develop a subunit vaccine candidate targeting BTV-16, a strain previously isolated in China from sheep with obvious clinical signs. Read More

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June 2018
3 Reads

Identification of antigenic epitopes of monoclonal antibodies against the VP2 protein of the 25 serotype of bluetongue virus.

Vet Microbiol 2018 Jun 11;219:136-143. Epub 2018 Apr 11.

College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China; Northeastern Science Inspection Station, China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, PR China. Electronic address:

Serious outbreaks of bluetongue, an arbovirus of domestic and wild ruminants caused by bluetongue virus serotypes (BTV), have occurred around the world. More than 27 distinct serotypes are recognized throughout the world. A new virus, BTV-25 (Toggenburg orbivirus [TOV]), was first detected in Switzerland, and has not yet been found in China. Read More

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June 2018
3 Reads

Diagnostic DIVA tests accompanying the Disabled Infectious Single Animal (DISA) vaccine platform for African horse sickness.

Vaccine 2018 06 11;36(25):3584-3592. Epub 2018 May 11.

Department of Virology, Wageningen Bioveterinary Research (WBVR), Lelystad, The Netherlands.

African Horse Sickness Virus (AHSV) (Orbivirus genus, Reoviridae family) causes high mortality in naïve domestic horses with enormous economic and socio-emotional impact. There are nine AHSV serotypes showing limited cross neutralization. AHSV is transmitted by competent species of Culicoides biting midges. Read More

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A correlation between capsid protein VP2 and the plaque morphology of African horse sickness virus in cell culture.

Virus Genes 2018 Aug 5;54(4):527-535. Epub 2018 May 5.

Agricultural Research Council - Onderstepoort Veterinary Institute, 100 Old Soutpan Rd, Pretoria, South Africa.

The attenuated live virus vaccine that is used in South Africa to protect against African horse sickness infection was developed more than 50 years ago. With the selection of the vaccine strains by cell culture passage, a correlation between the size of plaques formed in monolayer Vero cultures and attenuation of virus virulence in horses was found. The large plaque phenotype was used as an indication of cell culture adaptation and strongly correlated with attenuation of virulence in horses. Read More

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August 2018
9 Reads

Bluetongue Virus Antibodies in Domestic Goats: A Countrywide and Retrospective Study in the Republic of Korea.

Vector Borne Zoonotic Dis 2018 06 24;18(6):323-330. Epub 2018 Apr 24.

1 Department of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University , Incheon, Republic of Korea.

Bluetongue is a re-emergent arthropod-transmitted viral disease that affects all wild and domestic ruminant species, reducing herd productivity. The epidemiology of bluetongue virus (BTV) infection is poorly defined in much of the world, including extensive portions of Asia and the Middle East. In the Republic of Korea (ROK), scarce information is available on the status of BTV infection. Read More

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June 2018
15 Reads

Epizootic Hemorrhagic Disease Virus Serotype 6 Infection in Cattle, Japan, 2015.

Emerg Infect Dis 2018 05;24(5):902-905

During October-December 2015, an epizootic hemorrhagic disease outbreak occurred in cattle in Japan. Forty-six animals displayed fever, anorexia, cessation of rumination, salivation, and dysphagia. Virologic, serologic, and pathologic investigations revealed the causative agent was epizootic hemorrhagic disease virus serotype 6. Read More

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May 2018
2 Reads

Molecular differentiation and species composition of genus Culicoides biting midges (Diptera: Ceratopogonidae) in different habitats in southern China.

Vet Parasitol 2018 Apr 23;254:49-57. Epub 2018 Feb 23.

Nanchang Center for Disease Control and Prevention, Nanchang, 330038, PR China. Electronic address:

Culicoides biting midges (Diptera:Ceratopogonidae) cause a significant biting nuisance to humans, livestock, which are the biological vectors of a range of risky pathogens. Accurate illustration of vector play a key role in arthropod borne diseases surveillance. However, few studies have focused on the Culicoides, which caused bluetongue disease in 29 provinces of China since 1979. Read More

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April 2018
5 Reads

Evaluating the most appropriate pooling ratio for EDTA blood samples to detect Bluetongue virus using real-time RT-PCR.

Vet Microbiol 2018 Apr 3;217:58-63. Epub 2018 Mar 3.

The Pirbright Institute, Pirbright, Woking, Surrey, United Kingdom.

The control of Bluetongue virus (BTV) presents a significant challenge to European Union (EU) member states as trade restrictions are placed on animals imported from BTV-affected countries. BTV surveillance programs are costly to maintain, thus, pooling of EDTA blood samples is used to reduce costs and increase throughput. We investigated different pooling ratios (1:2, 1:5, 1:10 and 1:20) for EDTA blood samples to detect a single BTV positive animal. Read More

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April 2018
4 Reads

Seroprevalence of Bluetongue Virus in small ruminants in Balochistan province, Pakistan.

Transbound Emerg Dis 2018 Oct 31;65(5):1272-1281. Epub 2018 Mar 31.

University of Veterinary and Animal Sciences, Lahore, Pakistan.

Bluetongue (BT), caused by bluetongue virus (BTV), is a vector-borne disease of small ruminants that has the potential to spread across international borders. Despite large populations of susceptible animals and borders with BTV endemic countries, little is known of the disease burden and prevalent serotypes in the province of Balochistan in Pakistan. We conducted a cross-sectional study to determine seroconversion and prevalent serotypes in selected districts of the province using a competitive enzyme-linked immunosorbent assay (cELISA) and real-time polymerase chain reaction (RT-PCR). Read More

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October 2018

Prevalence and Risk Factors of Brucellosis, Chlamydiosis, and Bluetongue Among Sika Deer in Jilin Province in China.

Vector Borne Zoonotic Dis 2018 04 12;18(4):226-230. Epub 2018 Mar 12.

2 College of Chinese Medicinal Materials, Jilin Agricultural University , Changchun, People's Republic of China .

Brucellosis and chlamydiosis are important zoonotic diseases and bluetongue virus (BTV) is an arthropod-borne viral disease of ruminants. They are widely distributed around the world, cause large economic losses, and significant harmful effects on humans. However, epidemiological information relating to transmission from commercial sika deer in China is limited. Read More

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April 2018
2 Reads

An advection-deposition-survival model to assess the risk of introduction of vector-borne diseases through the wind: Application to bluetongue outbreaks in Spain.

PLoS One 2018 22;13(3):e0194573. Epub 2018 Mar 22.

VISAVET Center and Animal Health Department, Veterinary School, Universidad Complutense de Madrid, Madrid, Spain.

This work develops a methodology for estimating risk of wind-borne introduction of flying insects into a country, identifying areas and periods of high risk of vector-borne diseases incursion. This risk can be characterized by the role of suitable temperatures and wind currents in small insects' survival and movements, respectively. The model predicts the number density of introduced insects over space and time based on three processes: the advection due to wind currents, the deposition on the ground and the survival due to climatic conditions. Read More

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July 2018
4 Reads

Solubilisation and purification of recombinant bluetongue virus VP7 expressed in a bacterial system.

Protein Expr Purif 2018 Jul 15;147:85-93. Epub 2018 Mar 15.

Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Private Bag X6, Florida, Roodepoort, 1710, South Africa. Electronic address:

Bluetongue virus (BTV) is an Orbivirus that has a profound economic impact due to direct loss of livestock as well as movement bans in an attempt to prevent the spread of the disease to susceptible areas. BTV VP7, along with VP3, forms the inner capsid core of the virus where it acts as the barrier between the outer layer and the inner core housing the genetic material. Purification of BTV VP7 has proven to be problematic and expensive mainly due to its insolubility is several expression systems. Read More

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July 2018
3 Reads

Sero-epidemiology of bluetongue virus (BTV) infection in sheep and goats of Khyber Pakhtunkhwa province of Pakistan.

Acta Trop 2018 Jun 12;182:207-211. Epub 2018 Mar 12.

Department of Epidemiology and Public Health, University of Veterinary and Animal Sciences, Lahore, 54600, Pakistan.

Bluetongue virus (BTV) infection is an emerging hazard in small ruminants having socio-economic impacts on animals and associated people. The current study was aimed to estimate the sero-prevalence and associated risk factors in sheep and goat from Khyber Pakhtunkhwa (KP) province of Pakistan. Three distinct zones (northern, central and southern) with four districts (Mansehra, Abbottabad, Swabi, and Kohat) with a higher population of small ruminants were selected. Read More

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June 2018
16 Reads

Mosquito-Associated Viruses in China.

Virol Sin 2018 Feb 12;33(1):5-20. Epub 2018 Mar 12.

Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.

Mosquitoes are classified into approximately 3500 species and further grouped into 41 genera. Epidemiologically, they are considered to be among the most important disease vectors in the world and they can harbor a wide variety of viruses. Several mosquito viruses are considered to be of significant medical importance and can cause serious public health issues throughout the world. Read More

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February 2018
2 Reads

African horse sickness virus (AHSV) with a deletion of 77 amino acids in NS3/NS3a protein is not virulent and a safe promising AHS Disabled Infectious Single Animal (DISA) vaccine platform.

Vaccine 2018 04 7;36(15):1925-1933. Epub 2018 Mar 7.

Department of Virology, Wageningen Bioveterinary Research (WBVR), Lelystad, The Netherlands.

African horse sickness virus (AHSV) is a virus species in the genus Orbivirus of the family Reoviridae. Currently, nine serotypes have been defined showing limited cross neutralization. AHSV is transmitted by species of Culicoides biting midges and causes African Horse Sickness (AHS) in equids with a mortality up to 95% in naïve domestic horses. Read More

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Optimising cost-effectiveness of freedom from disease surveillance-Bluetongue Virus Serotype 8 as an example.

Prev Vet Med 2018 Nov 13;160:145-154. Epub 2018 Feb 13.

SAFOSO Inc., Safe Food Solutions, Bern-Liebefeld, Switzerland; Department of Veterinary Virology, Immunology and Parasitology, Salisburylaan 133, Ghent University, Merelbeke, Belgium.

The aim of this study was to propose a procedure for optimising the cost-effectiveness of vector borne disease surveillance using a scenario tree model and cost-effectiveness analysis. The surveillance systems for Bluetongue Virus serotype 8 (BTV-8) implemented in Switzerland and Belgium were used as examples. In twenty four different, simulated population structures, passive surveillance and five designs of active surveillance were investigated. Read More

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November 2018
5 Reads

Clinical presentation and pathology of suspected vector transmitted African horse sickness in South African domestic dogs from 2006 to 2017.

Vet Rec 2018 06 8;182(25):715. Epub 2018 Mar 8.

Department of Paraclinical Sciences, University of Pretoria, Pretoria, South Africa.

African horse sickness (AHS) is a fatal vector transmitted viral disease of horses caused by the African horse sickness virus (AHSV). This disease is characterised by circulatory and respiratory failure, resulting from vascular endothelial injury affecting many organs. The susceptibility of dogs to AHS has been demonstrated in the past following experimental infection through consumption of infected horse meat. Read More

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June 2018
2 Reads

Estimation of French cattle herd immunity against bluetongue serotype 8 at the time of its re-emergence in 2015.

BMC Vet Res 2018 Mar 2;14(1):65. Epub 2018 Mar 2.

ANSES, Laboratoire de Lyon, Unité Epidémiologie, Laboratoire de Lyon, Lyon, France.

Background: From 2006 to 2010, France experienced two bluetongue epidemics caused by serotype 1 (BTV-1) and 8 (BTV-8) which were controlled by mass vaccination campaigns. After five years without any detected cases, a sick ram was confirmed in August 2015 to be infected by a BTV-8 strain almost identical to that circulating during the previous outbreak. By then, part of the French cattle population was expected to be still protected, since bluetongue antibodies are known to last for many years after natural infection or vaccination. Read More

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March 2018
2 Reads

Analysis of Conserved, Computationally Predicted Epitope Regions for VP5 and VP7 Across three Orbiviruses.

Bioinform Biol Insights 2018 31;12:1177932218755348. Epub 2018 Jan 31.

Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Roodepoort, South Africa.

Orbiviruses are double-stranded RNA viruses that have profound economic and veterinary significance, 3 of the most important being African horse sickness virus (AHSV), bluetongue virus (BTV), and epizootic hemorrhagic disease virus (EHDV). Currently, vaccination and vector control are used as preventative measures; however, there are several problems with the current vaccines. Comparing viral amino acid sequences, we obtained an AHSV-BTV-EHDV consensus sequence for VP5 (viral protein 5) and for VP7 (viral protein 7) and generated homology models for these proteins. Read More

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January 2018
5 Reads

Bluetongue disease in small ruminants in south western Ethiopia: cross-sectional sero-epidemiological study.

BMC Res Notes 2018 Feb 8;11(1):112. Epub 2018 Feb 8.

Virus Laboratory, Center for Animal Disease Research and Diagnosis (CADRD), Indian Veterinary Research Institute (IVRI), Izatnagar, Uttar Pradesh, 243 122, India.

Objective: The status of bluetongue disease, vectors for transmission of the disease and the serotypes involved are not clearly known in Ethiopia. This sero-epidemiological study was conducted to determine the seroprevalence and associated risk factors of bluetongue in small ruminants of South Western Ethiopia.

Result: 422 serum samples were screened for the presence of bluetongue virus (BTV) specific antibodies using competitive enzyme-linked immunosorbent assay (c-ELISA) and 30. Read More

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February 2018
6 Reads

One after the other: A novel Bluetongue virus strain related to Toggenburg virus detected in the Piedmont region (North-western Italy), extends the panel of novel atypical BTV strains.

Transbound Emerg Dis 2018 Apr 2;65(2):370-374. Epub 2018 Feb 2.

OIE Reference Laboratory for Bluetongue, Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise (IZSAM), Teramo, Italy.

In this rapid communication, a novel atypical bluetongue virus (BTV) strain detected in goats in the Piedmont region (north-western Italy) is described. This strain, BTV-Z ITA2017, is most related in Seg-2/VP-2 (83.8% nt/82. Read More

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April 2018
3 Reads

Full genome sequence of the first bluetongue virus serotype 21 (BTV-21) isolated from China: evidence for genetic reassortment between BTV-21 and bluetongue virus serotype 16 (BTV-16).

Arch Virol 2018 May 1;163(5):1379-1382. Epub 2018 Feb 1.

Guangxi Key Laboratory of Veterinary Biotechnology, Guangxi Veterinary Research Institute, Nanning, 530001, Guangxi, China.

Bluetongue (BT) is one of the most important insect-borne, non-contagious viral diseases of ruminants and can cause severe disease and death in sheep. Its pathogen, bluetongue virus (BTV) has a double-stranded RNA genome consisting of 10 segments that provides an opportunity for field and vaccine strains of different serotypes to reassort whilst simultaneously infecting the same animal. For the first time, we report the full-length genome sequence of a BTV strain of serotype 21 (5149E) isolated from sentinel cattle in Guangxi Province in China in 2015. Read More

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May 2018
5 Reads

New species of the genus Culicoides (Diptera Ceratopogonidae) for Tunisia, with detection of Bluetongue viruses in vectors.

Vet Ital 2017 Dec;53(4):357-366

Université Tunis El Manar, Institut de la Recherche Vétérinaire de Tunisie, 20 Rue Djebel Lakdhar, 1006 La Rabta, Tunis, Tunisia.

Bluetongue virus (BTV) and Epizootic haemorrhagic disease virus (EHDV) are double-stranded RNA orbiviruses of the Reoviridae family. Bluetongue virus and EHDV infect domestic and wild ruminants and they are transmitted by biting midges of the genus Culicoides (Diptera: Ceratopogonidae). Since 1999, BTV outbreaks have occurred in Tunisia and 4 serotypes, BTV2, BTV1, BTV4 and BTV3, were involved in 2000, 2006, 2009, and 2016, respectively. Read More

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December 2017
1 Read

Bluetongue virus serotype 3 in Western Sicily, November 2017.

Vet Ital 2017 Dec;53(4):273-275

OIE Reference Laboratory for Bluetongue, Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Campo Boario, 64100 Teramo, Italy.

Bluetongue virus serotype 3 has been detected in a sheep in the Western part of the island of Sicily (Italy). This area is 150 km away from the peninsula of Cap Bon (Tunisia), where recent activities included in the Bluetongue National Surveillance plan demonstrated the widespread circulation of the same BTV strain. Read More

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December 2017
3 Reads

Investigating the effects of age-related spatial structuring on the transmission of a tick-borne virus in a colonially breeding host.

Ecol Evol 2017 12 12;7(24):10930-10940. Epub 2017 Nov 12.

Centre for Ecology & Hydrology Penicuik UK.

Higher pathogen and parasite transmission is considered a universal cost of colonial breeding due to the physical proximity of colony members. However, this has rarely been tested in natural colonies, which are structured entities, whose members interact with a subset of individuals and differ in their infection histories. We use a population of common guillemots, , infected by a tick-borne virus, , to explore how age-related spatial structuring can influence the infection costs borne by different members of a breeding colony. Read More

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December 2017
9 Reads

Environmental heterogeneity and variations in the velocity of bluetongue virus spread in six European epidemics.

Prev Vet Med 2018 Jan 4;149:1-9. Epub 2017 Nov 4.

Spatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Brussels, Belgium; Fonds National de la Recherche Scientifique (FNRS), Brussels, Belgium.

Several epidemics caused by different bluetongue virus (BTV) serotypes occurred in European ruminants since the early 2000. Studies on the spatial distribution of these vector-borne infections and the main vector species highlighted contrasted eco-climatic regions characterized by different dominant vector species. However, little work was done regarding the factors associated with the velocity of these epidemics. Read More

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January 2018
4 Reads

Bluetongue virus serotype 27: Experimental infection of goats, sheep and cattle with three BTV-27 variants reveal atypical characteristics and likely direct contact transmission BTV-27 between goats.

Transbound Emerg Dis 2018 Apr 15;65(2):e251-e263. Epub 2017 Dec 15.

Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.

Bluetongue virus (BTV) hitherto consisted of 26 recognized serotypes, of which all except BTV-26 are primarily transmitted by certain species of Culicoides biting midges. Three variants of an additional 27th bluetongue virus serotype (BTV-27v01-v03) were recently detected in asymptomatic goats in Corsica, France, 2014-2015. Molecular characterization revealed genetic differences between the three variants. Read More

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April 2018
2 Reads