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Eye (Lond) 2019 Feb 14. Epub 2019 Feb 14.

Department of Orbit, Oculoplasty & Ocular Oncology, Aravind Eye Hospital, Madurai, India.

Objective: Invasive sino-orbital fungal infections in immunocompetent patients are a rare clinical entity; the diagnosis and management of which is challenging. We present a large case series of invasive sino-orbital fungal granulomas in patients without pre-existing systemic immunocomprimising condition.

Design: Retrospective case series. Read More

Eur J Case Rep Intern Med 2018 27;5(12):000995. Epub 2018 Dec 27.

Department of Respiratory Medicine, Nicosia General Hospital, Cyprus.

Mucormycosis is a life-threatening fungal infection whose incidence has been rising recently, mainly due to the increasing use of immunosuppressive and corticosteroid treatment. In previous decades, mucormycosis was associated with a very poor prognosis as mortality was approximately 100%. Mortality rates reported in recent literature have only slightly improved despite the availability of targeted therapy with amphotericin B. Read More

Eur J Case Rep Intern Med 2018 31;5(1):000762. Epub 2018 Jan 31.

Infectious Diseases Department, Hospital de Santa Maria, Lisbon, Portugal.

Cysticercosis is triggered by infection with the larval form of the tapeworm . The usual sites for the development of cyscticerci are the central nervous system (neurocysticercosis - NCC), subcutaneous tissue, skeletal muscle, heart muscle, and the eye. Ocular cysticercosis is caused by the growth of the larvae within ocular tissues. Read More

J Maxillofac Oral Surg 2019 Mar 14;18(1):30-33. Epub 2017 Dec 14.

3Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Medical Sciences and Technology, Khartoum, Sudan.

Background: Orbital infection related to mandibular third molar infection is extremely rare. Most of cases reported in literature are related to maxillary molar teeth. Odontogenic infections are not common causes of orbital abscess but it should always be put in consideration when dealing with orbital cellulitis and abscess. Read More

Persoonia 2018 Dec 21;41:142-174. Epub 2018 Jun 21.

Laboratory of Fungal Genetics and Metabolism, Institute of Microbiology of the CAS, v.v.i, Vídeňská 1083, 142 20 Prague 4, Czech Republic.

Although is the major agent of invasive aspergillosis, an increasing number of infections are caused by its cryptic species, especially and the species complex (AVSC). Their identification is clinically relevant because of antifungal drug resistance and refractory infections. Species boundaries in the AVSC are unresolved since most species have uniform morphology and produce interspecific hybrids . Read More

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Cardiology, Komaki City Hospital, Japan.

A 69-year-old woman was admitted to our hospital with a fever, dizziness, and headache caused by Neisseria meningitidis. After ceftriaxone was administered, she suddenly developed bilateral oculomotor nerve palsy. Intra-orbital magnetic resonance imaging using appropriate sequences revealed that her bilateral third intracranial nerves were enlarged and enhanced. Read More

J Craniomaxillofac Surg 2019 Jan 17. Epub 2019 Jan 17.

Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea. Electronic address:

Importance: Conventional plating systems include titanium plates for the fixation of facial bone fractures. However, titanium plates result in artifacts on computed tomography images and appear unstable on magnetic resonance images. Therefore, absorbable plates have been widely used for the fixation of facial bone fractures of late in Asia. Read More

Infect Genet Evol 2019 Jan 30;69:203-210. Epub 2019 Jan 30.

Department of Ocular Microbiology, Aravind Eye Hospital, Madurai, India. Electronic address:

Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of vision threatening ocular infections. This study aimed to determine the prevalence and antimicrobial susceptibility pattern of MRSA and their genotypic characterization in ocular infections. The study period was from January 2007 to December 2017 in Aravind Eye Hospital, Madurai. Read More

Orbit 2019 Feb 1:1-7. Epub 2019 Feb 1.

f The Sussex Eye Hospital , Brighton and Sussex University Hospital , Brighton , UK.

Purpose: We present a series of primary orbital implant replacement for cases of implant exposure to describe our experience of this one-staged surgical approach.

Methods: This study reports on a one-stage technique which involved the removal of the exposed implant or dermis fat graft (DFG) and insertion of a secondary (replacement) in the same procedure, with a variety of materials, including autologous tissue. Re-exposure in a socket where a DFG was placed was defined as a new defect in the newly epithelialized conjunctiva or dehiscence of the dermis-conjunctiva junction. Read More

World J Clin Cases 2019 Jan;7(2):228-235

Department of Pathology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.

Background: Invasive fungal rhinosinusitis (IFR) caused by is very rare but has an extremely high fatality rate. There have been only seven cases of IFR caused by reported in English and, of these, only three patients survived. In this article, we present another case of IFR caused by , in which the patient was initially treated successfully but then deteriorated due to a relapse of leukemia 2 mo later. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;54(1):50-51

Department of Otorhinolaryngology Head and Neck Surgery, Second Hospital of Jilin University, Changchun 130041, China.

Ci Ji Yi Xue Za Zhi 2019 Jan-Mar;31(1):63-65

Department of Pediatrics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

Isolated sphenoid sinusitis is a rare disorder and may present with severe complications due to its proximity to the orbital and intracranial areas. We report a 13-year-old boy hospitalized for septic shock with fever of unknown origin. Facial palsy was later noted. Read More

J Plast Reconstr Aesthet Surg 2019 Jan 9. Epub 2019 Jan 9.

Division of Plastic, Reconstructive and Esthetic Surgery, Department of Surgery, Geneva University Hospitals and Faculty of Medicine, 4 Rue Gabrielle Perret-Gentil, 1211 Geneva 14, Switzerland.

Background: Median and paramedian craniofacial clefts are associated with hypertelorism, anterior encephalocele, positional abnormalities of the maxilla, and nasal deformity. Cleft lip and palate, eyelid coloboma, and widow's peak are frequently present.

Methods: The authors collected data from 30 patients (mean age, 5. Read More

BMC Ophthalmol 2019 Jan 24;19(1):29. Epub 2019 Jan 24.

Department of Ophthalmology, the 2nd Xiangya Hospital, Central South University, Changsha, 410011, Hunan Province, China.

Background: Bone wax is the most widely used hemostatic bone sealant because of its availability, ease of use, immediate action, and minimal adverse effects. Several complications have been reported to be associated with the use of bone wax, such as infection, osteohypertrophy, pain, granuloma formation, allergic reaction, and thrombosis. Here, we present a rare complication, namely, bone wax migration, which developed after a craniotomy on a patient who had a frontal sinus abnormality. Read More

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

Department of Biomedical, Metabolic, Neural Sciences, University Hospital of Modena.

itor Title: Varicella zoster virus reactivation antedating ipsilateral brainstem stroke Authors: Giuliana Galassi1, Maurilio Genovese2, Marisa Meacci3, Marcella Malagoli2 Affiliations: 1Department of Biomedical, Metabolic, Neural Sciences, University Hospital of Modena, Italy, 2Neuroradiology Service, University Hospital of Modena, Italy, 3Department of Laboratory Medicine and Patholgy, Microbiology and Virology Unit, University Hospital of Modena, Italy Corresponding Author: Giuliana Galassi, MD, Department of Biomedical, Metabolic, Neural Sciences, University Hospital of Modena, Via P. Giardini 1455, Modena, Italy, Tel: 39-3497325802, Email: giulianagalassi46@gmail.com Abstract: Varicella zoster virus (VZV) infection and reactivation are associated with a number of neurologic conditions. Read More

Drug Discov Ther 2018 ;12(6):374-378

Department of Medicine, All India Institute of Medical Sciences.

Mucormycosis is an uncommon aggressive fungal infection usually seen in immunocompromised hosts or patients with burns and trauma. The common presentations include rhino-orbital-cerebral and pulmonary involvement. Osteoarticular involvement is a rare presentation of this disease. Read More

J Craniofac Surg 2019 Jan 17. Epub 2019 Jan 17.

Department of Otolaryngology Head-Neck Surgery, Kosin University College of Medicine.

Background: The aim of the study was to compare the effectiveness of endoscopic endonasal reduction using a bioresorbable panel and silastic sheet packed with Merocel for blowout fractures of the medial orbital wall.

Design: Retrospective study.

Methods: The study group consisted of 147 patients who underwent endoscopic endonasal reduction of a blowout fracture of the medial orbital wall between January 2005 and December 2016. Read More

J Clin Med 2019 Jan 16;8(1). Epub 2019 Jan 16.

Otolaryngological Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.

Sinonasal-related orbital infections (SROIs) are typically pediatric diseases that occur in 3⁻4% of children with acute rhinosinusitis. They are characterised by various clinical manifestations, such as peri-orbital and orbital cellulitis or orbital and sub-periosteal abscesses that may develop anteriorly or posteriorly to the orbital septum. Posterior septal complications are particularly dangerous, as they may lead to visual loss and life-threatening events, such as an intracranial abscess and cavernous sinus thrombosis. Read More

Rev Soc Bras Med Trop 2019 Jan 14;52:e20180347. Epub 2019 Jan 14.

Universidade Federal de Minas Gerais, Faculdade de Medicina, Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Belo Horizonte, MG, Brasil.

Introduction: The recent circulation of arboviruses transmitted by vectors, such as dengue, chikungunya, and Zika, is concerning due to the high morbidity rates, clinical complications, and increased demand on health services. The objective of this study was to analyze the clinical and epidemiological aspects of an epidemic caused by arboviruses in the municipality of Santa Luzia, Minas Gerais, Brazil.

Methods: Longitudinal study of patients with acute febrile disease and suspected arbovirus infection reported to Brazilian Notifiable Disease Information System (Sistema de Informação de Agravos de Notificação) from the epidemiological week 44 of 2015 to epidemiological week 52 of 2016. Read More

Cesk Slov Oftalmol 2018 ;74(3):92-97

The etiology of papilloma formation is multifactorial. There is a strong association between human papillomavirus (HPV) and the development of these conjunctival lesions. HPV is tumorigenic and commonly produces benign tumors with low malignant potential. Read More

Br J Ophthalmol 2018 Dec 21. Epub 2018 Dec 21.

Oculoplastic and Orbital Service, The Rotterdam Eye Hospital, Rotterdam, The Netherlands.

Objective: To determine postoperative surgical site infection (SSI) rates in three separate patient groups who underwent orbital surgery without prophylactic systemic antibiotics.

Study Design: Single-centre retrospective descriptive case series.

Study Population: We studied the notes of 639 consecutive patients who had undergone orbital surgery in our hospital from 2009 through 2013. Read More

Eye (Lond) 2019 Feb 19;33(2):169-173. Epub 2018 Dec 19.

Professor Emerita, Institute of Infection & Immunity, School of Medicine, Cardiff, UK.

I was privileged to be one of the co-chairs, along with Professor Tim Sullivan (Brisbane, Australia), for the Cambridge Ophthalmological Society (COS) annual international symposium, which, this year, was dedicated to thyroid eye disease (TED). Together with the organisers, Miss Rachna Murthy and Professor Keith Martin from COS, we compiled an impressive programme covering all aspects of the condition from events happening in a single orbital cell to improved surgical approaches. Read More

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Neurology Department, North Bristol NHS Trust, Bristol, UK.

We report the case of a previously well 80-year-old man who presented with subacute bilateral painful optic neuropathy with initial response to corticosteroids but ultimately progressed to a fatal skull base syndrome. Initial presentation of steroid-responsive painful bilateral posterior optic neuropathy, preliminary normal enhanced MRI, normal cerebrospinal fluid and inflammatory markers indicated atypical optic neuritis. However, this progressed to a bilateral orbital apex syndrome with ophthalmoplegia and evidence of abnormal skull base enhancement on subsequent MRI. Read More

Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):e21-e22

Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, Tennessee, U.S.A.

This is the first reported case of necrotizing nasal and sinus herpes infection with orbital involvement. A 94-year-old male with a past medical history of hypertension, congestive heart failure, and chronic kidney disease presented with necrotic nasal cellulitis and a red left eye with blurry vision. Onset was 2 weeks prior with an upper lip fever blister. Read More

J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.

Plastic, Reconstructive, and Aesthetic Surgery Department of Mersin University Medical Faculty, Mersin, Turkey.

Ultra-thin porous polyethylene has been widely preferred in orbital blow out fracture repair for many years as a safe and stable material. Delayed complications related to the implant in orbital blow out fracture repair are very rare and usually begin as a periorbital inflammation. Infections and tissue reaction to the foreign body are regarded as main causes for implant-related inflammation of which symptoms may vary among the patients and may involve subacute and chronic eyelid swelling, skin redness, pain, conjunctival injection, proptosis, and acute orbital inflammation. Read More

Open Vet J 2018 22;8(4):445-451. Epub 2018 Nov 22.

Department of Clinical Sciences, Companion and Equine Animals, Ophthalmology, University of Liège, Quartier Vallée 2, Avenue de Cureghem 3, 4000 Liège, Belgium.

Orbital compartment syndrome (OCS) is described in humans as an acute rise in intraorbital pressure following a severe and rapidly evolving orbital affection. It includes orbital oedema, haemorrhage or infection causing a marked reduction in local blood perfusion, and severely affecting the orbital neurovascular structures. If not promptly recognised and treated, it results in irreversible blindness. Read More

Plast Reconstr Surg Glob Open 2018 Oct 15;6(10):e1908. Epub 2018 Oct 15.

Department of Plastic and Reconstructive Surgery, Kansai Medical University, Osaka, Japan.

For medial canthal tendon reattachment, many kinds of surgical technique have previously been reported. They are complicated and generally require technical skill and prolonged operating times. We, for the first time, describe a novel device, the Caraji Anchor Suture System, used for reattaching the medial canthal tendon to the medial orbital wall after removal of squamous cell carcinoma. Read More

J Craniofac Surg 2018 Dec 10. Epub 2018 Dec 10.

Department of Oral and Maxillofacial Surgery, the Second Hospital of Shandong University.

The reconstruction of orbital-maxillary-zygomatic complex (OMZC) on patients suffering from trauma and space-occupying lesions is challenging due to the irregularity of craniomaxillofacial bones. To overcome the challenge in precise OMZC reconstruction, individual three-dimensional (3D) disease models and mirror-imaged 3D reconstruction models were printed on the basis of the computer tomography. Preoperative planning by rehearsing surgical procedures was made on the 3D disease models and the scaffolds including titanium and absorbable meshes or plates were anatomically premolded using the mirror-imaged 3D models as guide. Read More

PLoS One 2018 6;13(12):e0208518. Epub 2018 Dec 6.

Infectious Diseases Institute, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America.

Staphylococcus aureus is an important human pathogen that causes serious antibiotic-resistant infections. Its population structure is marked by the appearance and dissemination of successful lineages across different settings. To begin understanding the population structure of S. Read More

Br J Ophthalmol 2018 Dec 4. Epub 2018 Dec 4.

Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Aim: To report the frequency and factors affecting patients', globe and vision survivals in rhino-orbito-cerebral mucormycosis (ROCM).

Methods: This is a retrospective study of 63 patients (79 eyes) with biopsy-proven ROCM at a university hospital 2008-2016. Systemic and ophthalmic manifestations, imaging, management and final outcomes were recorded. Read More

Otolaryngol Head Neck Surg 2018 Nov 27:194599818815109. Epub 2018 Nov 27.

3 Division of Otolaryngology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Objective: The microbiology of pediatric complicated acute rhinosinusitis (ARS) has evolved, and our current understanding of pathogenic organisms is limited. The objectives of this study are to describe the incidence of pathogens causing complicated ARS requiring surgical intervention at our institution over a 10-year period as well as their associated treatment outcomes.

Study Design: Retrospective cohort study. Read More

J Neurovirol 2018 Nov 26. Epub 2018 Nov 26.

Department of Radiology, Beijing Youan Hospital, Capital Medical University, No.8, Xi Tou Tiao, You An MenWai, Feng Tai District, Beijing, 100069, China.

Simian immunodeficiency virus (SIV)-infected macaque is a widely used model to study human immunodeficiency virus. The purpose of the study is to discover the amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) changes in SIV-infected macaques. Seven rhesus macaques were involved in the longitudinal MRI scans: (1) baseline (healthy state); (2) SIV infection stage (12 weeks after SIV inoculation). Read More

J Stomatol Oral Maxillofac Surg 2018 Nov 19. Epub 2018 Nov 19.

Recep Tayyip Erdogan University, Department of Pathology, Rize, Turkey.

An 81-year-old woman with diabetes mellitus presented with signs of orbital cellulitis and a gangrenous ulcer on the right palate. Biopsy analysis confirmed a diagnosis of necrotizing fasciitis. Surgical debridement of necrotic tissues and enucleation of the right eye were performed. Read More

J Craniofac Surg 2019 Jan;30(1):211-213

Department of Plastic and Reconstructive Surgery, Toho University Omori Medical Center, Tokyo, Japan.

Background: In primary reconstruction after maxillectomy for cancer, simple and less invasive surgical techniques considering functionality and aesthetics are necessary. The authors performed reconstruction for tissue defects after maxillectomy using an Ultra flex mesh plate and a free rectus abdominis myocutaneous flap including the aponeurosis of the external abdominal oblique muscle.

Method: A 72-year-old male with a maxillary squamous cell carcinoma underwent subtotal maxillectomy. Read More

J Craniofac Surg 2019 Jan;30(1):e58-e60

Department of Plastic and Reconstructive Surgery.

Purpose: To evaluate the utility and efficacy of bioabsorbable hydroxyapatite and collagen complex (HA/Col) for cranioplasty repair of cranial bone defects in children.

Methods: Two patients (a 6-year-old male and 11-year-old female) with Treacher Collins syndrome received zygoma and orbital floor reconstruction using a full thickness of parietal bone. The bone grafts were taken from each patient's parietal cranium. Read More

Ocul Immunol Inflamm 2018 Nov 16:1-3. Epub 2018 Nov 16.

b Ophthalmology , University of Rochester David and Ilene Flaum Eye Institute , Rochester , New York , USA.

Purpose: To describe an uncommon presentation of ocular infection caused by human herpes simplex virus 2 (HSV-2).

Methods: Case report.

Results: A 32-year-old female with no prior history of mucocutaneous herpesvirus infection presented with a minimally painful hypertensive granulomatous panophthalmitis and optic neuropathy that was initially suspected to be orbital cellulitis. Read More

Case Rep Ophthalmol Med 2018 21;2018:4746050. Epub 2018 Oct 21.

Department of Sense Organs, Sapienza University of Rome, Italy.

Plasmablastic lymphoma (PBL) is a malignant, rare, and aggressive form of non-Hodgkin's lymphoma with poor response to treatment that most commonly involves the oral mucosa of immunodeficient patients. The orbit might be primarily or secondarily involved; on the other hand other pathological conditions, i.e. Read More

Case Rep Oncol Med 2018 15;2018:6025274. Epub 2018 Oct 15.

Department of Internal Medicine, Einstein Medical Center Philadelphia, Philadelphia, USA.

Superior ophthalmic vein thrombosis is extremely rare and is often associated with orbital inflammation/infection, systemic/local tumors, hypercoagulable states, autoimmune conditions, and rarely carotid cavernous fistula. Clinical features include abrupt onset of painful proptosis, chemosis, ophthalmoplegia, and diminished visual acuity. Prompt diagnosis and treatment are essential to prevent permanent blindness. Read More

J Fungi (Basel) 2018 Oct 30;4(4). Epub 2018 Oct 30.

Department of Clinical Bacteriology and Mycology, The Kimron Veterinary Institute, P.O. Box 12, Bet Dagan 50250, Israel.

This review focuses on aspects of antimycotic therapy specific to veterinary medicine. In the first part, drug availability, limited mostly by economic consideration but also by clinical applicability and specific adverse effects, is described for polyenes, 5 fluorocytosine, azoles, echinocandins and terbinafine. In the second part, current knowledge and experience in the treatment of selected fungal infections are overviewed. Read More

Front Cell Infect Microbiol 2018 15;8:353. Epub 2018 Oct 15.

Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.

Fresh aqueous extracts (AGEs) and several thioallyl compounds (TACs) from garlic have an important antimicrobial activity that likely involves their interaction with exposed thiol groups at single aminoacids or target proteins. Since these groups are present in trophozoites, in this work we evaluated the anti-giardial activity of AGE and several garlic's TACs. susceptibility assays showed that AGE affected trophozoite viability initially by a mechanism impairing cell integrity and oxidoreductase activities while diesterase activities were abrogated at higher AGE concentrations. Read More

J Ophthalmol 2018 2;2018:4237573. Epub 2018 Oct 2.

Department of Ophthalmology, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, Taiwan.

Purpose: To report six cases of orbital cellulitis without preceding endophthalmitis.

Method: Retrospective chart review.

Results: We reported four females and two males admitted to our hospital for orbital cellulitis proven by computed tomographies and bacterial cultures from May 1995 to March 2017. Read More

Eur J Ophthalmol 2018 Oct 26:1120672118805299. Epub 2018 Oct 26.

3 Oculoplastic Unit, General Hospital of Granollers, Granollers, Spain.

Introduction:: Central graft ulceration is a rare complication of an orbital dermal fat graft caused by diminished blood supply to the implant. This study reports on the efficacy and safety of the use of a single subconjunctival injection of autologous platelet-rich plasma to rescue an ulcerated orbital dermal fat graft.

Methods:: Three patients, who had undergone autologous dermal fat graft to treat their anophthalmic socket, were given a 2-mL subconjunctival platelet-rich plasma injection in the exposed graft margins. Read More

Indian J Ophthalmol 2018 Nov;66(11):1647-1649

Department of Internal Medicine, Singapore General Hospital; Department of Ophthalmology, Duke-NUS Medical School, Singapore.

A 67-year-old male patient with poorly controlled type-2 diabetes mellitus developed an orbital apex syndrome and anterior cavernous syndrome secondary to herpetic zoster ophthalmicus (HZO), despite being on oral acyclovir. Urgent treatment with intravenous acyclovir led to improvement of the orbital and ocular inflammation but had no effect on the complete ophthalmoplegia and profound visual loss. At the 9-month follow-up visit, the patient had complete unilateral ophthalmoplegia and monocular blindness due to optic atrophy. Read More

SAGE Open Med Case Rep 2018 10;6:2050313X18803991. Epub 2018 Oct 10.

Department of Dermatology, College of Medicine, Korea University, Seoul, Republic of Korea.

Sarcoidosis is a multisystem inflammatory disease of unknown aetiology. Skin involvement has been reported in 12%-27% of patients with systemic disease, and scar sarcoidosis is a form of sarcoidosis developing in previous cutaneous scar areas. Scars due to all kinds of trauma, including surgery, vaccines, cosmetic tattoos, and herpes zoster infection, have been reported to be associated with sarcoidosis. Read More

Pan Afr Med J 2018 31;30:94. Epub 2018 May 31.

Radiology Departement, Mother and Child's Hospital, Mohammed VI Teaching Center, Medical School of Marrakesh, Cadi Ayad University, Marrakesh, Morocco.

Orbital cellulitis is rare but potentially severe in children. Diagnosis is primarily based on clinical examination and imaging (CT or MRI). This study aims to highlight the role of imaging, in particular CT scan, in the diagnosis and in the treatment of this pathology. Read More

Mycoses 2019 Feb 13;62(2):165-170. Epub 2018 Nov 13.

Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.

Background: Invasive mucormycosis is a rare but frequently fatal fungal disease. The acute and rapidly progressive evolution causes unfavourable outcome in 22%-59% of patients and its treatment represents a clinical challenge, especially in immunocompromised patients. Current data in paediatric oncological patients are limited. Read More

Tunis Med 2018 Mar;96(3):224-226

Purpose: To report a case of complete ophthalmoplegia and blindness in sino-orbital mucormycosis.

Case Report: A 68-year-old woman with history of diabetes and breast cancer presented with sudden onset of fever, orbital pain and blindness in the right eye. The patient was found to have no light perception, complete ophthalmoplegia, chemosis, corneal ulcer and optic nerve atrophy. Read More

J Cell Biochem 2018 Oct 15. Epub 2018 Oct 15.

Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Uveal melanoma (UM) is a severe human malignancy with a high mortality rate, as well as high metastasis and recurrence potential. The active mutation of G protein subunit alpha q (GNAQ) or G protein subunit alpha 11 (GNA11) is a major trigger for UM. Oncolytic adenovirus H101 (H101) is the first oncolytic virus approved for clinical applications in cancer therapy by the China Food and Drug Administration. Read More

Ophthalmic Plast Reconstr Surg 2018 Nov/Dec;34(6):e197-e201

Ruiz Department of Ophthalmology and Visual Science.

A 61-year-old man with well-controlled diabetes mellitus type 2, cirrhosis from hepatitis C, alcohol abuse, and portal hypertension presented with painful vision loss and left orbital swelling. Imaging showed diffuse orbital, perineural, and pachymeningeal inflammation. He was initially diagnosed with neurosarcoidosis. Read More

Ophthalmic Plast Reconstr Surg 2018 Oct 9. Epub 2018 Oct 9.

Department of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, U.S.A.

Purpose: To describe risk factors, clinical parameters, treatment, and prognosis for patients with septic cavernous sinus thrombosis presenting with orbital cellulitis.

Methods: Retrospective case series of 6 patients identified with septic cavernous sinus thrombosis and orbital cellulitis confirmed by magnetic resonance imaging at a tertiary care center from January 1980 to December 2016. Medical records were reviewed for demographics, risk factors, symptoms, etiology, radiographic diagnosis, complications, treatments, and outcomes. Read More