2,542 results match your criteria Oral diseases[Journal]


Activation of Mitophagy in Inflamed Odontoblasts.

Oral Dis 2019 Apr 22. Epub 2019 Apr 22.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedicine of Ministry of Education [KLOBM]), School and Hospital of Stomatology, Wuhan University, Wuhan, China.

Objectives: Mitophagy is an important mitochondrial quality control mechanism. In this study we investigated the mitochondrial damage and mitophagy occurred in inflammatory human dental pulp and lipopolysaccharide-stimulated preodontoblasts.

Materials And Methods: In dental pulp tissues and lipopolysaccharide-stimulated preodontoblasts, immunofluorescences and western blot were performed to detected the expression of mitochondrial and mitophagy-related proteins, autophagy markers were also examined. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.13110
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http://dx.doi.org/10.1111/odi.13110DOI Listing
April 2019
2 Reads

Novel Oral Lichen Planus Symptom Severity Measure for assessing patients' daily symptom experience.

Oral Dis 2019 Apr 21. Epub 2019 Apr 21.

AFYX Therapeutics, formerly known as Dermtreat, 2300, Copenhagen S, Denmark.

Objective: A novel Oral Lichen Planus Symptom Severity Measure was developed as a clinical outcome assessment of the daily symptom experience of patients with oral lichen planus.

Methods: A literature review and expert input were followed by open-ended concept elicitation interviews with 17 adults with oral lichen planus in the US and Ireland. Item content was generated and the interviews continued until input saturation was reached. Read More

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http://dx.doi.org/10.1111/odi.13109DOI Listing

Developing a new intelligent system for the diagnosis of oral medicine with case-based reasoning approach.

Oral Dis 2019 Apr 19. Epub 2019 Apr 19.

Department of Oral and Maxillofacial Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Since the clinical manifestations of many oral diseases can be quite similar despite the wide variety in etiology and pathology, the differential diagnosis of oral diseases is a complex and challenging process. Intelligent system for differential diagnosis of oral medicine using the artificial intelligence (AI) capabilities, helps specialists in achieving differential diagnosis in a wide range of oral diseases.

Materials And Methods: First, the essential data elements to design and develop an intelligent system were identified in a cross-sectional descriptive study. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.13108
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http://dx.doi.org/10.1111/odi.13108DOI Listing
April 2019
1 Read

Psychological disorders and quality of life in oral lichen planus patients and a control group.

Oral Dis 2019 Apr 16. Epub 2019 Apr 16.

Oral Medicine, Oral Surgery and Implantology Unit. Faculty of Medicine and Dentistry., Santiago de Compostela, Spain.

Objectives: oral lichen planus (OLP) is a common disease whose aetiopathogenesis is linked to psychological disorders. This study aims to determine the influence of anxiety and depression in OLP patients, define the perception of quality of life in these patients and check for potential differences between atrophic/ ulcerative and reticular lesions.

Material And Methods: a group of 48 OLP patients and a control group of 40 patients were selected. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.13106
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http://dx.doi.org/10.1111/odi.13106DOI Listing
April 2019
1 Read

Efficacy of a newly-developed mouth gel for xerostomia relief- a randomized double-blind trial.

Oral Dis 2019 Apr 10. Epub 2019 Apr 10.

University of Cologne, Centre of Dental Medicine, Department of Operative Dentistry and Periodontology, Kerpener Str. 32, 50931, Köln, Germany.

Objectives: To determine the efficacy of a new symptom-relieving mouth gel versus a widely-used control gel on xerostomic burden.

Materials And Methods: This randomized, double-blind, crossover trial investigated the efficacy of the test gel (Dr. Wolff Gel) versus control (Biotene) in participants with xerostomia (n=32; mean age 60 years). Read More

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http://dx.doi.org/10.1111/odi.13105DOI Listing

Association of Long Non-Coding RNA MEG3 Polymorphisms with Oral Squamous Cell Carcinoma Risk.

Oral Dis 2019 Apr 4. Epub 2019 Apr 4.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.

Objective: Long non-coding RNA (lncRNA) MEG3 was associated with multiple types of cancers such as Oral squamous cell carcinoma (OSCC). Single nucleotide polymorphisms (SNPs) might affect cancer risk by modified the function of lncRNAs. But fewer study researched the relationship between SNPs and MEG3 in cancers. Read More

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http://dx.doi.org/10.1111/odi.13103DOI Listing
April 2019
1 Read

Effects of oral healthcare motivation in patients with gingival oral lichen planus: a randomized controlled trial.

Oral Dis 2019 Apr 4. Epub 2019 Apr 4.

Centro Universitario di Odontoiatria, Dipartimento di Medicina e Chirurgia, Università di Parma, Parma, Italy.

Objectives: The role of dental plaque in gingival lesions caused by oral lichen planus has not been fully defined. The aim of this clinical trial was to evaluate the effects of oral healthcare motivation on clinical variables in patients with gingival oral lichen planus.

Materials And Methods: Oral lichen planus patients with symptomatic gingival lesions were randomized in control and intervention groups. Read More

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http://dx.doi.org/10.1111/odi.13104DOI Listing
April 2019
1 Read

Individual and contextual determinants of dental pain in adolescents: Evidence from a national survey.

Oral Dis 2019 Apr 2. Epub 2019 Apr 2.

School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Objective: To investigate the prevalence of dental pain among adolescent students and its association with individual, school and city variables, using a multilevel approach.

Subjects And Methods: Individual and school data were obtained from the National Adolescent School-Based Health Survey (PeNSE) conducted in Brazil in 2015 in a sample of 34,776 students from 1,339 schools in the 27 Brazilian capital cities. Secondary data on socioeconomic, structural and health indicators of the cities were obtained from public databases. Read More

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http://dx.doi.org/10.1111/odi.13100DOI Listing

Changing epidemiology of HCV infection in patients with oral lichen planus in north-west Italy.

Oral Dis 2019 Apr 2. Epub 2019 Apr 2.

Department of Surgical Sciences, Oral Medicine Section, CIR-Dental School, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1111/odi.13099DOI Listing

Frozen sections and complete resection in oral cancer surgery.

Oral Dis 2019 Apr 1. Epub 2019 Apr 1.

ENT Clinic, Head and Neck Department, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy.

Objectives: Although the reliability of frozen sections for the intraoperative assessment of complete tumour excision has been established, the best location for collection and the impact of the type of sampling are still debated. We retrospectively investigated the reliability of frozen sections when collected from the surgical bed as tissue strips representative of the whole superficial margin and as a bowl of tissue underlying the resection site for deep margin, and the possibility of relying on frozen section negativity to consider resections complete.

Materials And Methods: Frozen section reliability was calculated by comparing histology before and after formalin embedding and then categorised by sampling type, in 182 patients undergoing transoral resection of oral cancer. Read More

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http://dx.doi.org/10.1111/odi.13101DOI Listing
April 2019
1 Read

Oral epithelial membrane-associated mucins and transcriptional changes with Sjögren's syndrome.

Oral Dis 2019 Mar 28. Epub 2019 Mar 28.

Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida.

Objectives: To determine expression and localization of membrane-associated mucins within human keratinized and non-keratinized oral epithelia, and to explore transcriptional changes associated with primary Sjögren's syndrome.

Subjects And Methods: Mucin transcripts and glycoproteins were determined by RT-PCR and immunohistochemistry, respectively, in oral keratinized (hard palate) and non-keratinized (buccal) epithelia obtained from three cadavers. Mucin transcripts assessed by quantitative PCR were compared between cells harvested by brushing buccal and palatal epithelia of 25 female primary Sjögren's syndrome patients vs 25 healthy age-matched female control subjects. Read More

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http://dx.doi.org/10.1111/odi.13098DOI Listing
March 2019
2 Reads

The influence of vitamin D supplementation on local and systemic inflammatory markers in periodontitis patients: A pilot study.

Oral Dis 2019 Mar 26. Epub 2019 Mar 26.

Department of Periodontics, The Dental College of Georgia at Augusta University, Augusta, Georgia.

Objectives: Vitamin D deficiency/insufficiency is a worldwide public health issue that has been linked to numerous inflammatory disorders, including periodontitis. There is increasing support for a role for adequate vitamin D levels in overall health. Populations with darker skin color have a higher prevalence of vitamin D deficiency/insufficiency and periodontitis. Read More

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http://dx.doi.org/10.1111/odi.13097DOI Listing
March 2019
1 Read

Transplantation of dental pulp-derived cell sheets cultured on human amniotic membrane induced to differentiate into bone.

Oral Dis 2019 Mar 26. Epub 2019 Mar 26.

Department of Dental Medicine, Kyoto Prefectural University of Medicine, Graduate School of Medical Science.

Objective: The usefulness of the amniotic membrane as a cell culture substrate has led to its use in the development of dental pulp-derived cell sheets. We induced osteoblastic differentiation of dental pulp-derived cell sheets and conducted histological and immunological examinations in addition to imaging assessments for regeneration of bone defects.

Methods: Dental pulp cells were obtained by primary culture of the dental pulp tissue harvested from extracted wisdom teeth. Read More

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http://dx.doi.org/10.1111/odi.13096DOI Listing

Decreased expression of hsa_circ_0072387 as a valuable predictor for oral squamous cell carcinoma.

Oral Dis 2019 Mar 25. Epub 2019 Mar 25.

Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Qingdao University, Qingdao, China.

Objective: Increasing evidence points toward the key function of circular RNAs (circRNAs) in various carcinomas. This study aimed to identify aberrant expression of hsa_circ_0072387 in oral squamous cell carcinoma and probe its clinical significance.

Materials And Methods: Real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to assess hsa_circ_0072387 expression levels in 63 paired OSCC tissues and three OSCC cell lines. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.13094
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http://dx.doi.org/10.1111/odi.13094DOI Listing
March 2019
2 Reads

CTSC compound heterozygous mutations in 2 Chinese patients with Papillon-Lefèvre Syndrome.

Oral Dis 2019 Mar 25. Epub 2019 Mar 25.

National Clinical Research Centre for Oral Diseases, West China, College of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Objectives: To identify the molecular basis of Papillon-Lefèvre syndrome in 2 Chinese families.

Methods: Peripheral blood and mouth swab samples were obtained, from which genomic DNA and RNA were isolated. Sanger sequencing was employed to identify the mutations. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.13095
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http://dx.doi.org/10.1111/odi.13095DOI Listing
March 2019
4 Reads

The miR-3940-5p inhibits cell proliferation of gingival mesenchymal stem cells.

Oral Dis 2019 Mar 25. Epub 2019 Mar 25.

Department of Pediatric Dentistry, Tianjin Stomatology Hospital, Tianjin Medical University, Tianjin, China.

Objectives: Drug-induced gingival overgrowth (DIGO) is a well-recognized side effect of nifedipine (NIF). However, the molecular mechanisms of DIGO are still unknown. Here, we explored the possible role of miR-3940-5p in DIGO using NIF-treated gingival mesenchymal stem cells (GMSCs). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.13092
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http://dx.doi.org/10.1111/odi.13092DOI Listing
March 2019
12 Reads
2.427 Impact Factor

Exomic and transcriptomic alterations of hereditary gingival fibromatosis.

Oral Dis 2019 Mar 25. Epub 2019 Mar 25.

Department of Prosthodontics, College of Dentistry, Yonsei University, Seoul, Korea.

Objective: Hereditary gingival fibromatosis (HGF) is a rare oral disease characterized by either localized or generalized gradual, benign, non-hemorrhagic enlargement of gingivae. Although several genetic causes of HGF are known, the genetic etiology of HGF as a non-syndromic and idiopathic entity remains uncertain.

Subjects And Methods: We performed exome and RNA-seq of idiopathic HGF patients and controls, and then devised a computational framework that specifies exomic/transcriptomic alterations interconnected by a regulatory network to unravel genetic etiology of HGF. Read More

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http://dx.doi.org/10.1111/odi.13093DOI Listing

An update of knowledge on PD-L1 in head and neck cancers: Physiologic, prognostic and therapeutic perspectives.

Oral Dis 2019 Mar 13. Epub 2019 Mar 13.

School of Dentistry, University of Granada, Granada, Spain.

Programmed cell death-ligand 1 (PD-L1) is a transmembrane protein that acts as a co-inhibitory factor in the immune response. Its receptor, programmed cell death protein 1 (PD-1), is found on immune cells, where binding to PD-L1 can reduce the proliferation of PD-1-positive cells, inhibit their cytokine secretion and induce apoptosis. PD-L1 in immune-privileged tissue plays a crucial role in peripheral tolerance. Read More

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http://doi.wiley.com/10.1111/odi.13088
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http://dx.doi.org/10.1111/odi.13088DOI Listing
March 2019
5 Reads

Spindly and Bub3 expression in oral cancer: Prognostic and therapeutic implications.

Oral Dis 2019 Mar 13. Epub 2019 Mar 13.

Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Instituto Universitário de Ciências da Saúde, CESPU, Gandra, Portugal.

Objectives: Bub3 and Spindly are essential proteins required for the activation and inactivation of the spindle assembly checkpoint, respectively. Here, we explored the clinicopathological significance and the therapeutic potential of the opposing roles of the two proteins in oral squamous cell carcinoma (OSCC).

Materials And Methods: Bub3 and Spindly expression was evaluated by immunohistochemistry in 62 tissue microarrays from OSCC and by real-time PCR in OSCC cell lines and in normal human oral keratinocytes. Read More

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http://dx.doi.org/10.1111/odi.13089DOI Listing

Low prevalence of HPV-induced oral squamous cell carcinoma in Geneva, Switzerland.

Oral Dis 2019 Mar 6. Epub 2019 Mar 6.

Department of Surgery, Faculty of Medicine, Division of Oral Maxillofacial Surgery, Oral Maxillofacial Pathology Unit, Geneva University Hospitals, Geneva, Switzerland.

Objective: The main objective of this study was to analyze the presence of human papillomavirus (HPV) by polymerase chain reaction (PCR) in invasive squamous cell carcinomas of the oral cavity.

Materials And Methods: A selection was made of 155 cases of squamous cell carcinoma of the oral cavity treated at the University Hospital of Geneva. HPV detection was performed at the Laboratory of Molecular Pathology using a PCR technique followed by in situ hybridization of the viral DNA. Read More

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http://dx.doi.org/10.1111/odi.13084DOI Listing
March 2019
2 Reads

Response to Letter to the Editor "A window to consolidate the 'functional hypothesis of bruxism' through cardiovascular autonomic link".

Oral Dis 2019 May 19;25(4):1239-1240. Epub 2019 Mar 19.

Department of Biomedical, Odontostomatological Sciences and of Morphological and Functional Images, University of Messina, Messina, Italy.

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http://dx.doi.org/10.1111/odi.13078DOI Listing

A window to consolidate the "functional hypothesis of bruxism" through cardiovascular autonomic link.

Oral Dis 2019 May 19;25(4):1237-1238. Epub 2019 Mar 19.

Laboratório Experimental de Dor, Faculdade São Leopoldo Mandic, Campinas, Brasil.

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http://dx.doi.org/10.1111/odi.13077DOI Listing

Influence of bisphosphonates on clinical features of osteoradionecrosis of the maxilla and mandible.

Oral Dis 2019 Mar 1. Epub 2019 Mar 1.

Stomatology Department, School of Dentistry, São Paulo University, São Paulo, Brazil.

Background And Purpose: Osteoradionecrosis (ORN) is one of the most severe adverse effects of radiotherapy (RT) to the head and neck region. Medication-induced osteonecrosis of the jaw has been reported among patients using bisphosphonates. However, the impact of RT on osteonecrosis in patients using bisphosphonates has not yet been described. Read More

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http://dx.doi.org/10.1111/odi.13081DOI Listing
March 2019
1 Read

Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer.

Oral Dis 2019 May 27;25(4):1067-1075. Epub 2019 Mar 27.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

Objective: To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC-HE) among individuals with an initial oral/oropharyngeal cancer.

Materials And Methods: Mass screening data from Taiwan (2004-2009) included individuals who were ≥18 years old and smoked cigarettes and/or chewed betel quid. Occurrence of SPC-HE was monitored until December 31, 2014. Read More

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http://dx.doi.org/10.1111/odi.13080DOI Listing

Non-opioid pain management of head and neck chemo/radiation-induced mucositis: A systematic review.

Oral Dis 2019 Feb 27. Epub 2019 Feb 27.

University of North Carolina at Chapel Hill Chapel Hill, NC, USA.

Objective: To evaluate the current evidence regarding the effectiveness of non-opioid interventions for the therapeutic management of pain in head and neck cancer patients with oral mucositis resulting from radiotherapy only or chemoradiotherapy.

Materials And Methods: A literature search was conducted which included randomized controlled trials that assessed patient-related outcome of pain in patients with oral mucositis associated with radiation therapy only or chemoradiotherapy. Literature searches were conducted in MEDLINE via Pubmed, Embase, Scopus and CINAHL. Read More

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http://dx.doi.org/10.1111/odi.13074DOI Listing
February 2019
1 Read

Epigallocatechin-3-gallate inhibits proliferation and induces apoptosis in odontogenic keratocyst keratinocytes.

Oral Dis 2019 May 24;25(4):1175-1184. Epub 2019 Mar 24.

School of Stomatology, Qingdao University, Qingdao, China.

Objective: The aim of this study was to investigate the effects of epigallocatechin-3-gallate on the proliferation and apoptosis of odontogenic keratocyst (OKC) keratinocytes in vitro.

Materials And Methods: Keratinocytes isolated from the epithelial lining of the OKC were cultured in keratinocyte serum-free medium and identified by CK10, CK14, pan-cytokeratin and vimentin immunofluorescence staining. The cells were exposed to EGCG at different concentrations, and proliferation inhibition was measured by cell counting kit 8 assay. Read More

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http://dx.doi.org/10.1111/odi.13073DOI Listing
May 2019
2 Reads

BRAF V600E expression in ameloblastomas-A 36-patient cohort from Helsinki University Hospital.

Oral Dis 2019 May 19;25(4):1169-1174. Epub 2019 Mar 19.

Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objectives: We aimed to investigate BRAF V600E percentage immunohistochemically in ameloblastomas of a single institute cohort. We were interested if age, location, histological properties, or tumor recurrence depend on the BRAF status.

Subjects, Materials And Methods: We had 36 formalin-fixed, paraffin-embedded ameloblastoma tissue samples of patients treated at the Helsinki University Hospital between the years 1983-2016. Read More

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http://dx.doi.org/10.1111/odi.13072DOI Listing

Optical fluorescence imaging in oral cancer and potentially malignant disorders: A systematic review.

Oral Dis 2019 Feb 27. Epub 2019 Feb 27.

Australian Centre for Oral Oncology Research & Education, Nedlands, Western Australia, Australia.

Objectives: This study aimed to systematically review the efficacy of direct optical fluorescence imaging as an adjunct to comprehensive oral examination in the clinical evaluation, risk assessment and surgical management of oral cancer and potentially malignant disorders.

Methods: Studies adopting autofluorescence devices, evaluating the efficacy of comprehensive oral examination and optical fluorescence imaging in detection, visualisation or management of oral squamous cell carcinoma or oral potentially malignant disorders, as well as discriminating oral epithelial dysplasia from other mucosal lesions, were included in the literature search across bibliographic databases until October 2018.

Results: Twenty-seven studies were found to be eligible for inclusion in qualitative analysis. Read More

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http://dx.doi.org/10.1111/odi.13071DOI Listing
February 2019

Bcl-2 is a prognostic marker and its silencing inhibits recurrence in ameloblastomas.

Oral Dis 2019 May 15;25(4):1158-1168. Epub 2019 Mar 15.

Department of Oral Pathology, Oral Cancer Research Institute, Seoul, Republic of Korea.

Objectives: Ameloblastomas are the most common odontogenic epithelial tumors with high recurrence rate. The aim of this study was to identify apoptosis-related genes with recurrence of ameloblastomas and to evaluate its feasibility as a prognostic marker and as a target molecule preventing from recurrence.

Materials And Methods: Public microarray data were analyzed. Read More

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http://dx.doi.org/10.1111/odi.13070DOI Listing
May 2019
3 Reads

Subset of CD8+ and FOXP3 + T cells in lichen planus associated with chronic hepatitis C infection.

Oral Dis 2019 May 15;25(4):1100-1106. Epub 2019 Mar 15.

Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil.

Objective: To verify whether there are differences between populations of CD8 + and FoxP3 + T cells in lesions of oral lichen planus associated with hepatitis C virus chronic infection (OLP-HCV) and lesions of idiopathic oral lichen planus (OLP-I).

Materials And Methods: A case-control study was performed using a convenience sample of 11 paraffin-embedded tissue blocks of OLP-HCV and 19 of OLP-I. Histological sections stained with haematoxylin and eosin were used to classify the intensity of inflammatory infiltrate. Read More

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http://dx.doi.org/10.1111/odi.13069DOI Listing
May 2019
2 Reads

Effects of miRNA-342-3p in modulating Hedgehog signaling pathway of human umbilical cord mesenchymal stem cells by down-regulating Sufu.

Oral Dis 2019 May 11;25(4):1147-1157. Epub 2019 Mar 11.

Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: Previously, we have shown that miRNA-342-3p was increased during osteogenic differentiation of human umbilical mesenchymal stem cells (hUCMSCs) via regulating the sonic hedgehog (Shh) pathway. In this study, our objective is to further investigate the role of miRNA-342-3p in activation of Shh pathway by targeting suppressor of fused protein (Sufu), a suppressor of transcriptional factor Gli, as well as the potential interaction with transforming growth factor beta (TGF-β) signaling pathway during osteogenic induction of hUCMSCs.

Materials And Methods: HUCMSCs that stable overexpression or knockdown of miRNA-342-3p were established by infection with lentiviral vectors. Read More

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http://dx.doi.org/10.1111/odi.13068DOI Listing

World Workshop on Oral Medicine VII: Burning Mouth Syndrome: A Systematic Review of Disease Definitions and Diagnostic Criteria Utilized in Randomized Clinical Trials.

Oral Dis 2019 Feb 20. Epub 2019 Feb 20.

Department of Oral Health Practice, University of Kentucky, College of Dentistry, 800 Rose Street, Lexington, KY, 40536-0297.

Objective: To conduct a systematic review analyzing disease definitions and diagnostic criteria used in randomized controlled trials (RCTs) involving burning mouth syndrome (BMS).

Methods: A systematic search conducted in PubMed, Web of Science, PsycINFO, Cochrane Database/Cochrane Central, and Google Scholar that included RCTs on BMS published between 1994 and 2017 was performed.

Results: Considerable variability in BMS disease definitions and diagnostic criteria used created substantial heterogeneity in the selection of participants and weakened the rigor of the 36 RCTs identified. Read More

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http://dx.doi.org/10.1111/odi.13067DOI Listing
February 2019
1 Read

Necrotizing sialometaplasia can hide the presence of salivary gland tumors: A case series.

Oral Dis 2019 May 5;25(4):1084-1090. Epub 2019 Mar 5.

Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Objective: Necrotizing sialometaplasia (NS) is an uncommon benign process which affects minor and, more rarely, major salivary glands. While self-limiting, the condition might be clinically and histologically mistaken for malignancy. Furthermore, NS may accompany neoplasms. Read More

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http://doi.wiley.com/10.1111/odi.13066
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http://dx.doi.org/10.1111/odi.13066DOI Listing
May 2019
17 Reads

Gene expression profiling of Jagged1-treated human periodontal ligament cells.

Oral Dis 2019 May 5;25(4):1203-1213. Epub 2019 Mar 5.

Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.

Objective: Jagged1 regulates several biological functions in human periodontal ligament cells (hPDLs). The present study aimed to evaluate mRNA expression profiling of Jagged1-treated hPDLs using microarray technique.

Methods: Notch ligands, Jagged1, were indirectly immobilized on tissue culture surface. Read More

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http://dx.doi.org/10.1111/odi.13065DOI Listing

The fibroblast of radicular cyst facilitate osteoclastogenesis via the autocrine of Fibronectin containing extra domain A.

Oral Dis 2019 May 18;25(4):1136-1146. Epub 2019 Mar 18.

Department of Pathology, School & Hospital of Stomatology, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Tongji University, Shanghai, China.

Objective: To investigate the alternative spliced isoforms of Fibronectin (FN) in the stroma of radicular cysts and analyze the associations between these isoforms and the osteoclastogenic effects of fibroblasts.

Methods And Materials: The specimens of radicular cysts were stained with immunohistochemistry, and the associations between each FN isoform and clinical parameters were assessed. The fibroblasts isolated from cysts or jaw bone were cultured to induce the Trap + MNCs. Read More

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http://dx.doi.org/10.1111/odi.13064DOI Listing
May 2019
1 Read

Autophagy-related gene expression regulated by HIF-1α in salivary adenoid cystic carcinoma.

Oral Dis 2019 May 3;25(4):1076-1083. Epub 2019 Mar 3.

Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Objectives: Salivary adenoid cystic carcinoma (SACC) is one of the most common malignant salivary gland tumors. Our study aims to investigate whether hypoxia-induced autophagy was up-regulated in the progression of SACC.

Materials And Methods: We performed differentially expressed gene analysis and pathway enrichment analysis and then calculated the correlation analysis on GSE59701 and GSE28996 datasets. Read More

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http://dx.doi.org/10.1111/odi.13058DOI Listing
May 2019
5 Reads

Sex hormone replacement therapy in periodontology-A systematic review.

Oral Dis 2019 Feb 10. Epub 2019 Feb 10.

Department of Stomatology, Federal University of Paraná (UFPR), Curitiba, Brazil.

Objective: To analyse whether sex hormone replacement therapy (HRT) improves periodontal parameters and dental implants osseointegration in humans.

Materials And Methods: Electronic databases and hand searches were performed from June to August 2018 in SciELO, LILACS and PubMed/MEDLINE. Human observational and interventional studies that evaluated the following parameters were included: clinical attachment loss (CAL), probing pocket depth (PPD), bleeding on probing (BOP), radiographic bone loss (RBL) or osseointegration. Read More

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http://dx.doi.org/10.1111/odi.13059DOI Listing
February 2019
2 Reads

The effects of ozone therapy on periodontal therapy: A randomized placebo-controlled clinical trial.

Oral Dis 2019 May 3;25(4):1195-1202. Epub 2019 Mar 3.

Faculty of Dentistry, Department of Periodontology, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.

Objectives: The aim of this randomized split-mouth clinical trial was to evaluate the effects of ozone therapy on clinical and biochemical parameters of moderate to severe generalized periodontitis patients after non-surgical periodontal therapy.

Methods: A total of 36 moderate to severe generalized periodontitis patients were included in the study. The patients were systemically healthy and 18 to 64 years of age. Read More

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http://dx.doi.org/10.1111/odi.13060DOI Listing
May 2019
1 Read

Role of mammary serine protease inhibitor on the inflammatory response in oral lichen planus.

Oral Dis 2019 May 27;25(4):1091-1099. Epub 2019 Mar 27.

Department of Oral Medicine, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, China.

Objectives: Oral lichen planus (OLP) is a chronic inflammatory condition with an unclear pathological mechanism. IκB kinase α (IKKα)-regulated mammary serine protease inhibitor (MASPIN) has been shown to mediate inflammation, particularly in cancers. Here, we explored the expression of MASPIN in OLP and its role in the inflammatory response. Read More

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http://doi.wiley.com/10.1111/odi.13054
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http://dx.doi.org/10.1111/odi.13054DOI Listing
May 2019
11 Reads

Oral health and associated factors among preschool children with special healthcare needs.

Oral Dis 2019 May 21;25(4):1221-1228. Epub 2019 Feb 21.

Periodontology and Public Health, Faculty of Dentistry, 2/F Prince Philip Dental Hospital, The University of Hong Kong, Hong Kong SAR, China.

Objective: To investigate the oral health status and associated factors among preschool children with special healthcare needs.

Subjects And Methods: This was designed as a cross-sectional study. Dental examination was provided to 383 children at Special Child Care Centres. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.13057
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http://dx.doi.org/10.1111/odi.13057DOI Listing
May 2019
10 Reads

Patient-derived xenografts of a case of ameloblastic fibrodentinoma.

Oral Dis 2019 May 27;25(4):1229-1233. Epub 2019 Feb 27.

Departament of Pathology, Biological Science Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

Objectives: The establishment of animal models of xenotransplantation can contribute to the elucidation of the molecular pathogenesis of ameloblastic fibrodentinomas (AFD) and it also provides an opportunity for drug tests. We aimed to evaluate the possibility of AFD tumour growth in a patient-derived xenograft (PDX) model. In addition, we characterized the human tumour and the PDXs. Read More

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http://dx.doi.org/10.1111/odi.13056DOI Listing
May 2019
5 Reads

Zoledronate treatment duration is linked to bisphosphonate-related osteonecrosis of the jaw prevalence in rice rats with generalized periodontitis.

Oral Dis 2019 May 19;25(4):1116-1135. Epub 2019 Feb 19.

Department of Physiological Sciences, University of Florida, Gainesville, Florida.

Objectives: To determine the extent that zoledronate (ZOL) dose and duration is associated with bisphosphonate-related osteonecrosis of the jaw (BRONJ) prevalence in rice rats with generalized periodontitis (PD), characterize structural and tissue-level features of BRONJ-like lesions in this model, and examine the specific anti-resorptive role of ZOL in BRONJ.

Materials And Methods: Rice rats (n = 228) consumed high sucrose-casein diet to enhance generalized PD. Groups of rats received 0, 8, 20, 50 or 125 µg/kg IV ZOL/4 weeks encompassing osteoporosis and oncology ZOL doses. Read More

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http://dx.doi.org/10.1111/odi.13052DOI Listing
May 2019
7 Reads

The reciprocal association between diabetes mellitus and erosive oral lichen planus.

Oral Dis 2019 May 27;25(4):1235-1236. Epub 2019 Feb 27.

State Key Laboratory of Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

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http://dx.doi.org/10.1111/odi.13050DOI Listing
May 2019
4 Reads

Perioperative changes in knowledge and attitude toward oral health by oral health education.

Oral Dis 2019 May 21;25(4):1214-1220. Epub 2019 Mar 21.

Division of Oral Science for Health Promotion, Niigata University, Niigata, Japan.

Objectives: Perioperative oral health care can prevent postoperative complications, but it is also important to maintain oral health afterward to avoid later adverse events. This study examined (a) the relationship between knowledge and attitude toward oral health (KAOH) and oral/periodontal status (OPS) in patients receiving surgery, and (b) the changes in KAOH by perioperative oral health care and education.

Methods: Patients receiving surgery who visited our hospital's dental clinic beforehand were prospectively recruited. Read More

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http://doi.wiley.com/10.1111/odi.13048
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http://dx.doi.org/10.1111/odi.13048DOI Listing
May 2019
5 Reads

Preoperative circulating platelet, neutrophil, and lymphocyte counts predict survival in oral cancer.

Oral Dis 2019 May 11;25(4):1057-1066. Epub 2019 Feb 11.

Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Jiangsu, China.

Objective: Circulating immune-inflammatory cells have been increasingly recognized as robust prognostic biomarkers in cancer. Here, we sought to evaluate the prognostic values of preoperative peripheral platelet, neutrophil, lymphocyte quantitation in patients with primary oral squamous cell carcinoma (OSCC).

Materials And Methods: A total number of 309 patients with primary OSCC surgically treated at our institutions were retrospectively included. Read More

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http://dx.doi.org/10.1111/odi.13049DOI Listing
May 2019
1 Read
2.427 Impact Factor

Bacteremia after professional mechanical plaque removal in patients with chronic periodontitis.

Oral Dis 2019 May 11;25(4):1185-1194. Epub 2019 Mar 11.

Institute of Medical Microbiology and Epidemiology on Infectious Diseases, Leipzig, Germany.

Objective: The aim of this study was to investigate the characteristics of bacteremia caused by professional mechanical plaque removal (PMPR) in two groups of patients with generalized moderate chronic periodontitis.

Materials And Methods: Venous blood samples were taken at multiple time points for one hour following PMPR in fifty patients with generalized moderate chronic periodontitis. Subjects consisted of two groups, one group was receiving supportive periodontal therapy (SPT, n = 25) and the other group was receiving initial periodontal therapy (IPT, n = 25). Read More

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http://dx.doi.org/10.1111/odi.13047DOI Listing
May 2019
2 Reads

The role of autophagy in the pathogenesis of periodontal disease.

Oral Dis 2019 Jan 23. Epub 2019 Jan 23.

Department of Stomatology, Tongji Hospital of Tongji Medical College of Huazhong, University of Science and Technology, Wuhan, China.

Periodontal disease is a chronic inflammatory disease leading to destruction of periodontal tissues. As a local inflammation, periodontopathic bacterium, pro-inflammatory mediators, and local immune response play pivotal role in the progress of periodontal disease. Besides, cigarette smoke has long been associated with periodontal disease and tooth loss. Read More

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http://doi.wiley.com/10.1111/odi.13045
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http://dx.doi.org/10.1111/odi.13045DOI Listing
January 2019
12 Reads

Systemic comorbidities are associated with medication-related osteonecrosis of the jaws: Case-control study.

Oral Dis 2019 May 19;25(4):1107-1115. Epub 2019 Feb 19.

Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia.

Objectives: Medication-related osteonecrosis of the jaws (MRONJ) is a serious condition developed in up to 15% of patients who take antiresorptive medications. Its underlying pathogenesis remains unclear. The association between systemic comorbidities and MRONJ was investigated. Read More

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http://dx.doi.org/10.1111/odi.13046DOI Listing
May 2019
6 Reads

Azithromycin and erythromycin susceptibility and macrolide resistance genes in Prevotella from patients with periodontal disease.

Oral Dis 2019 Apr 7;25(3):860-867. Epub 2019 Feb 7.

Department of Microbiology, Dentaid Research Center, Cerdanyola del Vallès, Spain.

Objectives: To study oral Prevotella spp. isolated from patients with chronic periodontitis, to determine their susceptibility to azithromycin and erythromycin and to screen the presence of macrolide resistance genes therein.

Material And Methods: Isolates with a Prevotella-like morphology were obtained from subgingival samples of 52 patients with chronic periodontitis. Read More

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http://dx.doi.org/10.1111/odi.13043DOI Listing
April 2019
1 Read

Influence of Porphyromonas gingivalis in gut microbiota of streptozotocin-induced diabetic mice.

Oral Dis 2019 Apr 10;25(3):868-880. Epub 2019 Feb 10.

Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Objectives: Increasing evidence suggests that periodontitis can exacerbate diabetes, and gut bacterial dysbiosis appears to be linked with the diabetic condition. The present study examined the effects of oral administration of the periodontopathic bacterium, Porphyromonas gingivalis, on the gut microbiota and systemic conditions in streptozotocin-induced diabetic mice.

Materials And Methods: Diabetes was induced by streptozotocin injection in C57BL/6J male mice (STZ). Read More

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http://dx.doi.org/10.1111/odi.13044DOI Listing
April 2019
2.427 Impact Factor