1,051,838 results match your criteria Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology[Journal]


Early Premature Infant Oral Motor Intervention Improved Oral Feeding and Prognosis by Promoting Neurodevelopment.

Am J Perinatol 2019 Apr 23. Epub 2019 Apr 23.

Department of Pediatrics, Liaocheng People's Hospital, Liaocheng, Shandong, China.

Objective:  To explore the clinical significance of early premature infant oral motor intervention (PIOMI) in the prognosis of premature infants.

Study Design:  Infants were randomly divided into an intervention group ( = 78) and a control group ( = 73). PIOMI was given to the intervention group 15 to 30 minutes before feeding once a day for 14 days. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685448
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http://dx.doi.org/10.1055/s-0039-1685448DOI Listing
April 2019
1 Read

Does the 5-Aminosalicylate Concentration Correlate with the Efficacy of Oral 5-Aminosalicylate and Predict Response in Patients with Inflammatory Bowel Disease? A Systematic Review.

Digestion 2019 Apr 23:1-17. Epub 2019 Apr 23.

Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: Oral 5-aminosalicylic acid (5-ASA, mesalazine) is the first choice therapeutic agent for treating mild-to-moderate ulcerative colitis (UC). Unfortunately a significant group of patients fail to respond. Therapeutic drug monitoring might help to maintain or induce remission by providing a tool for optimization of 5-ASA therapy. Read More

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https://www.karger.com/Article/FullText/499331
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http://dx.doi.org/10.1159/000499331DOI Listing
April 2019
1 Read

Consumption of Sugar-Sweetened Beverages in Paediatric Age: A Position Paper of the European Academy of Paediatrics and the European Childhood Obesity Group.

Ann Nutr Metab 2019 Apr 23;74(4):296-302. Epub 2019 Apr 23.

Medical Faculty, University of Rzeszów, Rzeszów, Poland.

Background: Health risks associated with the high consumption of sugar-sweetened beverages (SSBs) include overweight or obesity and their complications such as diabetes, as well as oral and dental decay, among others.

Aim: The aim of the present statement is to inform health care professionals, parents, care-givers, teachers and school head teachers, stakeholders and governing bodies about the risks associated with drinking SSBs in infants, children and adolescents.

Methods: We searched PubMed and the Cochrane databases for English language studies published from 2010 through October 1, 2018, for randomized clinical trials, meta-analyses, systematic reviews and observational studies (search terms are reported in eAppendix in the Supplement). Read More

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http://dx.doi.org/10.1159/000499828DOI Listing

Anticholinergic Burden and Dry Mouth in Middle-Aged People.

JDR Clin Trans Res 2019 Apr 23:2380084419844511. Epub 2019 Apr 23.

1 Periodontology and Geriatric Dentistry, Unit of Oral Health Sciences Research, University of Oulu, Oulu, Finland.

Introduction: Anticholinergic burden refers to the cumulative effect of taking 1 or more drugs with anticholinergic properties. At the moment, little is known about the association between the anticholinergic burden and dry mouth.

Objectives: The objective of this article was to study, whether an anticholinergic burden is associated with dry mouth among middle-aged people. Read More

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http://dx.doi.org/10.1177/2380084419844511DOI Listing

Regulation of PGLYRP1 and TREM-1 during Progression and Resolution of Gingival Inflammation.

JDR Clin Trans Res 2019 Apr 23:2380084419844937. Epub 2019 Apr 23.

1 Section of Periodontology and Dental Prevention, Division of Oral Diseases of Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.

Introduction: The triggering receptor expressed on myeloid cells 1 (TREM-1) signaling pathway is stimulated by bacteria and, together with its putative ligand peptidoglycan recognition protein 1 (PGLYRP1), propagates proinflammatory responses.

Objectives: We aimed to evaluate the TREM-1/PGLYRP1/interleukin (IL)-1β regulation in response to biofilm accumulation and removal in an experimental human gingivitis model.

Methods: The study (n = 42 participants, mean age: 23. Read More

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http://dx.doi.org/10.1177/2380084419844937DOI Listing

Letters From Our Readers.

Authors:
Wentian Sun Jun Liu

Angle Orthod 2019 May;89(3):522

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. (e-mail: ).

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http://dx.doi.org/10.2319/0003-3219-89.3.522DOI Listing

Discovery and Lead-optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.

J Med Chem 2019 Apr 23. Epub 2019 Apr 23.

RIP1 kinase regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including inflammatory and neurological diseases. Currently RIP1 kinase inhibitors have advanced into early clinical trials for evaluation in inflammatory diseases such as psoriasis, rheumatoid arthritis and ulcerative colitis, and neuro-logical diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. In this paper we report on the design of potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitors starting from a high-throughput screen and the lead-optimization of this series from a lead with minimal rat oral exposure to the identification of dihydropyrazole 77 with good pharmacokinetic profiles in multiple species. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.9b00318DOI Listing

[Allergy to food in adults with allergic respiratory diseases: prevalence and clinical manifestations].

Rev Alerg Mex 2019 Jan-Mar;66(1):1-8

Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Servicio de Alergia e Inmunología Clínica, Guadalajara, México.

Background: Food allergy is considered a typical problem in the pediatric population, however, cases occur in adults more frequently.

Objective: To determine the prevalence of food allergy in patients with allergic rhinitis and asthma; as well as the foods and symptoms most related to said problem.

Methods: Through a cross-sectional study, the information of 257 adults with asthma or allergic rhinitis was analyzed. Read More

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http://dx.doi.org/10.29262/ram.v66i1.400DOI Listing

Inhibition of adhesion-specific genes by Solidago virgaurea extract causes loss of Candida albicans biofilm integrity.

J Appl Microbiol 2019 Apr 23. Epub 2019 Apr 23.

Université Aix-Marseille, AP-HM, IRD, VITROME, IHU Méditerranée Infection, Marseille, France.

Aims: Candida albicans biofilms are commonly associated to severe oral infections. We previously discovered that a crude extract from the Solidago virgaurea plant (SV-extract) was a potent inhibitor of C. albicans biofilm formation. Read More

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http://dx.doi.org/10.1111/jam.14289DOI Listing

Construct Cyan Fluorescence by De Novo Tripeptides: An In Vitro Mutation Study on the Role of Single Amino Acid Residues and Their Sequence.

Chembiochem 2019 Apr 23. Epub 2019 Apr 23.

Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, P. R. China., Yuexiu Road, CHINA.

Amino acids are a natural choice as building blocks for developing bio-functional entities owing to their superior diversity and versatile physicochemical properties compared to nucleotide bases. A simple permutation of amino acids creates a broad palette of proteins that are successfully engineered as useful bio-functional agents. For example, the intrinsic ultraviolet fluorescence of phenylalanine (F) and tryptophan (W) have been engineered to emit in the visible spectrum [1, 2], that has broad applications as imaging/sensing probes, photothermal therapy agents, optogenetic switches, etc. Read More

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http://dx.doi.org/10.1002/cbic.201900166DOI Listing

Drug levels and bleeding complications in atrial fibrillation patients treated with direct oral anticoagulants.

J Thromb Haemost 2019 Apr 23. Epub 2019 Apr 23.

Arianna Anticoagulazione Foundation, Bologna, Italy.

Background: Direct oral anticoagulants (DOACs) are administered at fixed dose. Aim of the study was to evaluate the relationship between DOAC C-trough or C-peak plasma levels, and bleeding complications in patients with non-valvular atrial fibrillation (NVAF).

Methods: 565 consecutive naive NVAF patients were enrolled. Read More

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http://dx.doi.org/10.1111/jth.14457DOI Listing

Surgical nurses' perceptions and experiences of a medications and oral restrictions policy change: a focus group study.

J Clin Nurs 2019 Apr 23. Epub 2019 Apr 23.

Surgical Clinical Service Unit, Austin Health, Melbourne, Australia.

Aims And Objectives: To explore the perceptions and experiences of surgical nurses before and after introducing the Medications and Oral Restrictions Policy (the Policy).

Background: The Policy was developed following extensive consultation, and evidence-based strategies were considered for its implementation. However, it is possible uptake did not meet expectations. Read More

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http://dx.doi.org/10.1111/jocn.14898DOI Listing

Parent and child perception of quality of life in a randomized controlled peanut oral immunotherapy trial.

Pediatr Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.

Background: Improved quality of life (QoL) after oral immunotherapy (OIT) in peanut allergic children is often reported by their parents, while the child's perspective is less clear.

Objective: We aimed to explore if two years of OIT improved QoL in children with peanut allergy and to identify factors influencing change in QoL.

Methods: In the open labelled TAKE-AWAY peanut OIT trial including children with anaphylaxis to peanuts, 57 were randomized to OIT and 20 to observation. Read More

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http://dx.doi.org/10.1111/pai.13066DOI Listing

Novel MRI assessment of treatment response in HIV-associated NAFLD: a randomized trial of an SCD1 inhibitor (ARRIVE Trial).

Hepatology 2019 Apr 23. Epub 2019 Apr 23.

NAFLD Research Center, Department of Medicine, La Jolla, California.

Aramchol, an oral stearoyl-coenzyme-A-desaturase-1 (SCD1) inhibitor, has been shown to reduce hepatic-fat content in patients with primary nonalcoholic-fatty-liver-disease (NAFLD), however, its effect in patients with HIV-associated NAFLD is unknown. The ARRIVE trial was a double-blind, randomized, investigator-initiated, placebo-controlled trial to test the efficacy of 12 weeks of treatment with aramchol versus placebo in HIV-associated NAFLD. Fifty patients with HIV-associated NAFLD, defined by MRI-proton-density-fat-fraction (PDFF) ≥5%, were randomized to receive either aramchol 600 mg daily (n=25) or placebo (n=25) for 12 weeks. Read More

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http://dx.doi.org/10.1002/hep.30674DOI Listing

Tranexamic acid through intravenous, intramuscular and oral routes: an individual participant data meta-analysis of pharmacokinetic studies in healthy volunteers.

Fundam Clin Pharmacol 2019 Apr 23. Epub 2019 Apr 23.

Unité de Recherche Clinique, INSERM, Hôpital Cochin-Necker, Université Paris Descartes, Sorbonne-Paris Cité, Paris, France.

Background: Tranexamic acid (TXA) is an antifibrinolytic drug that reduces surgical blood loss and death due to bleeding after trauma and post-partum haemorrhage. One key issue for treatment success is early administration. While usually given intravenously, oral and intramuscular use would be useful in specific circumstances. Read More

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http://dx.doi.org/10.1111/fcp.12474DOI Listing

Oral health related quality of life, oral esthetics and oral function in head and neck cancer patients after oral rehabilitation.

J Oral Rehabil 2019 Apr 23. Epub 2019 Apr 23.

Section of Oral Rehabilitation, Department of Odontology, University of Copenhagen.

Background: Head and neck cancer (HNC) is diagnosed in more than 500.000 patients every year worldwide with increasing prevalence. Oral rehabilitation is often needed after HNC-treatment to regain oral function, esthetics and oral health related quality of life (OHRQoL). Read More

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http://dx.doi.org/10.1111/joor.12806DOI Listing

Strategies to improve adherence and continuation of shorter-term hormonal methods of contraception.

Cochrane Database Syst Rev 2019 Apr 23;4:CD004317. Epub 2019 Apr 23.

Research Utilization, FHI 360, 359 Blackwell St, Suite 200, Durham, North Carolina, USA, 27701.

Background: Worldwide, hormonal contraceptives are among the most popular reversible contraceptives. Despite high perfect-use effectiveness rates, typical-use effectiveness rates for shorter-term methods such as oral and injectable contraceptives are much lower. In large part, this disparity reflects difficulties in ongoing adherence to the contraceptive regimen and low continuation rates. Read More

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http://dx.doi.org/10.1002/14651858.CD004317.pub5DOI Listing

WITHDRAWN: Flossing for the management of periodontal diseases and dental caries in adults.

Cochrane Database Syst Rev 2019 Apr 23;4:CD008829. Epub 2019 Apr 23.

Center for Evidence-Based Medicine and Health Care, Catholic University of Croatia, Ilica 242, Zagreb, Croatia, 10000.

Background: Good oral hygiene is thought to be important for oral health. This review is to determine the effectiveness of flossing in addition to toothbrushing for preventing gum disease and dental caries in adults.

Objectives: To assess the effects of flossing in addition to toothbrushing, as compared with toothbrushing alone, in the management of periodontal diseases and dental caries in adults. Read More

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http://dx.doi.org/10.1002/14651858.CD008829.pub3DOI Listing

Correlation Between Sleep-Time Masseter Muscle Activity and Tooth Wear: An Electromyographic Study.

J Oral Facial Pain Headache 2019 Spring;33(2):199-204

Aims: To assess the correlation between tooth wear and sleep-time masseter muscle activity (sMMA) in a group of healthy young adults who underwent home electromyographic/electrocardiographic (EMG/ECG) recordings with a portable device.

Methods: A total of 41 healthy volunteers (23 women, 18 men; mean age 28.8 years, range 25 to 40) with good natural dentition underwent a 2-night in-home evaluation with a portable device that allowed a simultaneous sleep-time recording of EMG signals from both masseter muscles and heart rate. Read More

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http://quintpub.com/journals/ofph/abstract.php?iss2_id=1605&
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http://dx.doi.org/10.11607/ofph.2081DOI Listing
April 2019
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Can nano-hydroxyapatite permeate the oral mucosa? A histological study using three-dimensional tissue models.

PLoS One 2019 23;14(4):e0215681. Epub 2019 Apr 23.

Sangi Co., Ltd, Central Research Laboratory, Kasukabe, Saitama, Japan.

Nano-hydroxyapatite is used in oral care products worldwide. But there is little evidence yet whether nano-hydroxyapatite can enter systemic tissues via the oral epithelium. We investigated histologically the ability of two types of nano-hydroxyapatite, SKM-1 and Mi-HAP, to permeate oral epithelium both with and without a stratum corneum, using two types of three-dimensional reconstituted human oral epithelium, SkinEthic HGE and SkinEthic HOE respectively with and without a stratum corneum. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215681PLOS

Pacemaker Dysfunction due to a Large Thrombus on Ventricular Lead.

Heart Surg Forum 2019 Mar 11;22(2):E131-E133. Epub 2019 Mar 11.

Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Background: Pacemaker lead-related thrombosis is a rare but severe complication in patients with pacing lead implantation in the right ventricle. We present a case with recurrent syncope after single-chamber implantable cardioverter defibrillator (ICD) implantation. Pacing lead-related thrombosis was observed during open-heart surgery. Read More

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http://dx.doi.org/10.1532/hsf.2291DOI Listing

Extended-spectrum β-lactamase in the rectal flora of patients undergoing transrectal prostate biopsy: a study of the prevalence in a major metropolitan hospital.

BJU Int 2019 Apr 23. Epub 2019 Apr 23.

Department of Urology, Royal Melbourne Hospital, Parkville, Vic., Australia.

Objectives: To determine the prevalence of extended-spectrum β-lactamase (ESBL) in patients undergoing transrectal prostate biopsy, to assess the incidence of postoperative sepsis, to correlate the development of sepsis with the presence of preoperative ESBL on rectal swabs, and to assess the adequacy of prophylactic antibiotic guidelines in the context of local ESBL prevalence.

Methods: Patients undergoing transrectal ultrasonography (TRUS)-guided biopsy at the Royal Melbourne Hospital between January 2012 and July 2016 had rectal swabs taken immediately prior to TRUS with specific cultures to identify the presence of ESBL. Patients were given a prophylactic antibiotic, 500 mg oral ciprofloxacin, 1 h before the TRUS procedure. Read More

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http://dx.doi.org/10.1111/bju.14745DOI Listing

Safety, Pharmacokinetics, and Pharmacodynamics of the Autotaxin Inhibitor GLPG1690 in Healthy Subjects: Phase 1 Randomized Trials.

J Clin Pharmacol 2019 Apr 23. Epub 2019 Apr 23.

Galapagos Biotech Limited, Cambridge, United Kingdom.

GLPG1690 is a novel autotaxin inhibitor in development for the treatment of idiopathic pulmonary fibrosis (IPF). We report phase 1 studies investigating the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of GLPG1690 in healthy subjects. We performed a first-in-human randomized, double-blind, placebo-controlled trial of single (20, 60, 150, 300, 600, 1000, 1500 mg) and multiple (14 days: 150 mg twice daily; 600 and 1000 mg once daily) ascending oral doses of GLPG1690 (NCT02179502), and a randomized, open-label, crossover relative bioavailability study to compare the PK of tablet and capsule formulations of GLPG1690 600 mg and to assess the effect of food on PK of the tablet formulation (NCT03143712). Read More

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http://dx.doi.org/10.1002/jcph.1424DOI Listing

Mangosteen Vinegar Rind from Garcinia mangostana Prevents High-Fat Diet and Streptozotocin-Induced Type II Diabetes Nephropathy and Apoptosis.

J Food Sci 2019 Apr 23. Epub 2019 Apr 23.

Biomedical Sciences, School of Allied Health Sciences, Walailak Univ., Nakhon Si Thammarat, 80161, Thailand.

Type II diabetes (T2D) nephropathy, a major cause of end-stage kidney disease, progresses and develops from oxidative stress. Natural polyphenols can protect the kidney from diabetic nephropathy exerting antioxidant activities. The present approach enumerates the reno-protective and anti-apoptotic effects of mangosteen vinegar rind (MVR, a phenolic aqueous extract) against high-fat diet (5 g/day up to five weeks)-/streptozotocin (single ip, dose 30 mg/kgBW)-induced T2D nephropathy of albino mice. Read More

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http://dx.doi.org/10.1111/1750-3841.14511DOI Listing

A phase 1 trial of the oral DNA methyltransferase inhibitor CC-486 and the histone deacetylase inhibitor romidepsin in advanced solid tumors.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland.

Background: Epigenetic abnormalities are manifold in all solid tumors and include changes in chromatin configuration and DNA methylation. The authors designed a phase 1 study to evaluate the oral DNA methyltransferase inhibitor CC-486 combined with the histone deacetylase inhibitor romidepsin in advanced solid tumors with dose expansion to further evaluate pharmacodynamics and possible clinical benefit of the recommended phase 2 dose (RP2D).

Methods: This was a phase 1 study with a 3 + 3 dose-escalation design and an expansion phase for patients with virally mediated cancers. Read More

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http://dx.doi.org/10.1002/cncr.32138DOI Listing

Survival outcomes by high-risk human papillomavirus status in nonoropharyngeal head and neck squamous cell carcinomas: A propensity-scored analysis of the National Cancer Data Base.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.

Background: The prognostic relevance of human papillomavirus (HPV) status in patients with nonoropharyngeal (OPX) squamous cell cancer (SCC) of the head and neck is controversial. In the current study, the authors evaluated the impact of high-risk HPV status on overall survival (OS) in patients with non-OPX SCC using a large database approach.

Methods: The National Cancer Data Base was queried to identify patients diagnosed from 2004 through 2014 with SCC of the OPX, hypopharynx (HPX), larynx, and oral cavity (OC) with known HPV status. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32115
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http://dx.doi.org/10.1002/cncr.32115DOI Listing

Impact of oral administration of four strains on Nugent score - systematic review and meta-analysis.

Benef Microbes 2019 Apr 23:1-14. Epub 2019 Apr 23.

2 Clinical Research Center, Schauenburgerstraβe 116, 24118 Kiel, Germany.

We aimed at assessing the evidence for an effect on vaginal dysbiosis by oral administration of a mixture of strains isolated from vaginal microbiota. For this purpose, we systematically reviewed the literature for randomised clinical trials (RCTs) in which the effect of oral administration of a mixture of four strains ( LbV 88 (DSM 22566), LbV 150N (DSM 22583), LbV 116 (DSM 22567) and LbV96 (DSM 22560)) on vaginal dysbiosis was examined based on Nugent score. Four RCTs were identified: a double-blind (DB)-RCT in 60 male-to-female transsexual women with neovagina; an open label RCT in 60 pregnant women with herpes virus infection; a DB-RCT in 36 women with bacterial vaginosis; a DB-RCT in 22 postmenopausal breast cancer patients receiving chemotherapy. Read More

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http://dx.doi.org/10.3920/BM2018.0129DOI Listing

Natural resolution of non-anaphylactic shrimp allergy in patients diagnosed 10 years earlier by oral food challenge.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Division of Allergy and Clinical Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Shrimp allergy is considered a lifelong condition. The natural resolution of shrimp allergy is not well studied.

Objective: To investigate the natural resolution of shrimp allergy among a cohort of patients diagnosed with shrimp allergy 10 years earlier by oral shrimp challenge. Read More

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http://dx.doi.org/10.12932/AP-080119-0470DOI Listing

[Oral cavity microbiocenosis assessment on the basis of bacterial endotoxin and plasmalogens in a saliva by method GAS-liquid chromatography-mass spectrometry.]

Klin Lab Diagn 2019 ;64(3):186-192

G.N. Gabrichevsky research institute for epidemiology and microbiology, Rospotrebnadzor, Moscow, Russia.

The concentration of plasmalogen bacterial and endotoxin levels in the saliva of patients with different severity of periodontal disease, injury prosthetic bed and with various degrees of the oral cavity microbiocenosis violations was studied. Determination of the presence of the pathological process was carried out clinically, according to the condition of periodontal tissues. The degree of microbiological disorders was assessed by the quantitative ratio of the types of microorganisms isolated from the smear taken from the gingival groove. Read More

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http://dx.doi.org/10.18821/0869-2084-2019-64-3-186-192DOI Listing
January 2019

Assessment of swallowing function with oro-pharyngeal-esophageal scintigraphy in patients with idiopathic inflammatory myopathies.

Neurogastroenterol Motil 2019 Apr 23:e13599. Epub 2019 Apr 23.

Rheumatology Unit, University of Pisa, Pisa, Italy.

Background: Swallowing impairment is frequently present in patients with idiopathic inflammatory myopathies (IIMs), and it represents an important cause of morbidity, dramatically reducing the quality of life of patients. Moreover, dysphagia is associated to a worst prognosis. Unfortunately, no standardized instrumental techniques for the assessment of the upper gastrointestinal tract in IIM patients are available. Read More

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http://dx.doi.org/10.1111/nmo.13599DOI Listing

The significance of tumor budding in oral cancer survival and its relevance to the eighth edition of the American Joint Committee on Cancer staging system.

Head Neck 2019 Apr 23. Epub 2019 Apr 23.

Department of Stomatology, Oral & Maxillofacial Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: To explore the clinicopathological significance of tumor budding (TB) on oral squamous cell carcinoma (OSCC) prognosis.

Methods: Data of 200 patients with OSCC were retrieved from the cancer registration database in Taipei Veterans General Hospital. Clinicopathological characteristics and survival relevant to TB were analyzed. Read More

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http://dx.doi.org/10.1002/hed.25780DOI Listing

Impact of Parkinson's disease on the efficiency of masticatory cycles: Electromyographic analysis.

Med Oral Patol Oral Cir Bucal 2019 Apr 23. Epub 2019 Apr 23.

School of Dentistry of Ribeirão Preto University of São Paulo. Avenida do Café s/n, Bairro Monte Alegre CEP 14040-904 Ribeirão Preto, SP, Brazil

Background: This study evaluated the efficiency of masticatory cycles by means of the linear envelope of the electromyographic signal of the masseter and temporalis muscles in individuals with Parkinson's disease.

Material And Methods: Twenty-four individuals were assigned into two groups: with Parkinson's disease, average ± SD 66.1 ± 3. Read More

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http://dx.doi.org/10.4317/medoral.22841DOI Listing

Diagnosing and treating antiphospholipid syndrome: a consensus paper.

Neth J Med 2019 Apr;77(3):98-108

Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, the Netherlands.

Introduction: The antiphospholipid syndrome (APS) is defined by the occurrence of venous and/or arterial thrombosis and/or pregnancy-related morbidity, combined with the presence of antiphospholipid antibodies (aPL) and/or a lupus anticoagulant (LAC). Large, controlled, intervention trials in APS are limited. This paper aims to provide clinicians with an expert consensus on the management of APS. Read More

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P300 values in patients diagnosed with primary Sjogren syndrome.

Somatosens Mot Res 2019 Apr 23:1-5. Epub 2019 Apr 23.

a Department of Neurology , Diskapi Yildirim Beyazit Egitim ve Arastirma Hastanesi , Ankara , Turkey.

Purpose: Primary Sjogren syndrome (PSS) is an autoimmune disease characterized by symptoms of a dry mouth and eyes, in which other organs and systems are widely involved. Central nervous system (CNS) involvement in PSS is reported in a wide range between 2.5-60%. Read More

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http://dx.doi.org/10.1080/08990220.2019.1604333DOI Listing

Short-Course Pentoxifylline Is Not Effective in Post-Traumatic Smell Loss: A Pilot Study.

Ear Nose Throat J 2019 Apr 23:145561319840888. Epub 2019 Apr 23.

1 Department of Otorhinolaryngology, Smell and Taste Clinic, Technische Universität Dresden, Dresden, Germany.

It has been suggested that systemic pentoxifylline may be beneficial in the treatment of olfactory dysfunction. The postulated mechanism of action involves nonselective competitive phosphodiesterase inhibition, leading to increased intracellular cyclic adenosine monophosphate and consequent increased olfactory neuron activity. This should in theory lead to improved olfactory function. Read More

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http://dx.doi.org/10.1177/0145561319840888DOI Listing

3D Bioprinting in Skeletal Muscle Tissue Engineering.

Small 2019 Apr 23:e1805530. Epub 2019 Apr 23.

Center for Minimally Invasive Therapeutics (C-MIT), Department of Radiological Sciences, University of California, Los Angeles, CA, 90095, USA.

Skeletal muscle tissue engineering (SMTE) aims at repairing defective skeletal muscles. Until now, numerous developments are made in SMTE; however, it is still challenging to recapitulate the complexity of muscles with current methods of fabrication. Here, after a brief description of the anatomy of skeletal muscle and a short state-of-the-art on developments made in SMTE with "conventional methods," the use of 3D bioprinting as a new tool for SMTE is in focus. Read More

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http://dx.doi.org/10.1002/smll.201805530DOI Listing

Impact of novel oral anticoagulants vs warfarin on effusions after coronary artery bypass grafting.

J Card Surg 2019 Apr 23. Epub 2019 Apr 23.

Division of Cardiovascular and Thoracic Surgery, Zucker School of Medicine at Hofstra/Northwell, Manhasset, New York.

Background: Novel oral anticoagulants (NOAC) have been shown to have comparable risk profiles compared with warfarin. However, data on the use of NOACs in cardiac surgery patients is limited. The aim of this study is to compare postoperative effusion rates in patients who were anticoagulated with NOACs vs warfarin after coronary artery bypass grafting (CABG). Read More

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http://dx.doi.org/10.1111/jocs.14054DOI Listing

Epigallocatechin-3-gallate inhibits migration of human nasopharyngeal carcinoma cells by repressing MMP-2 expression.

J Cell Physiol 2019 Apr 22. Epub 2019 Apr 22.

Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan.

Metastasis of the cancer cells to the regional lymph nodes parts of the body remains an important cause of treatment failure in nasopharyngeal carcinoma (NPC) patients. Epigallocatechin-3-gallate (EGCG), the most important ingredient in the green tea, has been reported to possess antioxidant and anticancer activities. However, the effects of EGCG on NPC cell metastasis are still unclear. Read More

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http://dx.doi.org/10.1002/jcp.28696DOI Listing

A storytelling intervention reduces childhood caries risk behaviors among American Indian and Alaska Native mothers in Northern California.

J Public Health Dent 2019 Apr 23. Epub 2019 Apr 23.

Department of Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA.

Objectives: To evaluate a storytelling intervention targeting the oral health beliefs, knowledge, and behaviors of AIAN pregnant women and mothers.

Methods: Fifty-three adult AIAN women from three tribal communities in Northern California participated. The intervention story delivered oral health messaging using a traditional storytelling format. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jphd.12318
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http://dx.doi.org/10.1111/jphd.12318DOI Listing
April 2019
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Old treatments for new genetic conditions: Sirolimus therapy in a child affected by mosaic overgrowth with fibroadipose hyperplasia.

Clin Genet 2019 Apr 22. Epub 2019 Apr 22.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Center for Rare Diseases and Birth Defects, Department of Woman and Child Health, Rome, Italy.

PIK3CA-related overgrowth spectrum (PROS) are overgrowth diseases involving mesenchymal tissues caused by postzygotic variants in the PIK3CA gene. Fibro-Adipose hyperplasia or Overgrowth (FAO) belongs to PROS. We reported the beneficial effect of oral low-dose sirolimus therapy in a child affected by progressive FAO in term of stabilization of the disease, good tolerability, and easy management. Read More

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http://dx.doi.org/10.1111/cge.13550DOI Listing

A Randomized, Placebo-Controlled, Double-Blind Study that Evaluates Efficacy of Intravenous Ibuprofen and Acetaminophen for Postoperative Pain Treatment Following Laparoscopic Cholecystectomy Surgery.

J Gastrointest Surg 2019 Apr 22. Epub 2019 Apr 22.

Department of General Surgery, Istanbul Medipol University, Bagcilar, 34000, Istanbul, Turkey.

Background: Ibuprofen is a NSAID that has anti-inflammatory, antipyretic, and analgesic effects. The oral form of the drug has been used safely for a long time and is one of the most preferred NSAIDs. It has been shown that ibuprofen is effective in the treatment of postoperative pain; however, there have not been sufficient studies on ibuprofen. Read More

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http://dx.doi.org/10.1007/s11605-019-04220-1DOI Listing

Oral or intravenous vinorelbine plus capecitabine in heavily pretreated HER2 negative metastatic breast cancer; similar effect or quality of life?

Authors:
Kadri Altundag

Breast Cancer Res Treat 2019 Apr 23. Epub 2019 Apr 23.

MKA Breast Cancer Clinic, Tepe Prime, 06800, Cankaya, Ankara, Turkey.

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http://dx.doi.org/10.1007/s10549-019-05220-0DOI Listing

Independent relationships of daily life activity and leisure-time exercise with metabolic syndrome and its traits in the general Japanese population.

Endocrine 2019 Apr 22. Epub 2019 Apr 22.

Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Purpose: This study aimed to investigate independent relationships of daily non-exercise life activity and leisure-time exercise volume and intensity with the prevalence of metabolic syndrome and its traits in Japanese adults.

Methods: Data of 24,625 eligible subjects (12,709 men, 11,916 women) who participated in the baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study were analyzed. Information about lifestyle characteristics was obtained from a questionnaire. Read More

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http://dx.doi.org/10.1007/s12020-019-01926-9DOI Listing

Infected Cemento-Osseous Dysplasia: Analysis of 66 Cases and Literature Review.

Head Neck Pathol 2019 Apr 22. Epub 2019 Apr 22.

Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Room 3202 D. Pampulha, Belo Horizonte, MG, CEP: 31.270-901, Brazil.

The aim of this study was to describe a series with 66 cases of infected cemento-osseous dysplasia (COD) and to discuss the demographic distribution, clinicoradiographic features and treatment of this condition. A study looking back on the diagnoses made at a single Brazilian centre within a 28-year timeframe was performed. A literature review with searches across five databases was also conducted to identify reports on osteomyelitis/infected COD. Read More

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http://link.springer.com/10.1007/s12105-019-01037-x
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http://dx.doi.org/10.1007/s12105-019-01037-xDOI Listing

Secular Trends in Long-Term Oral Bisphosphonate Use.

J Gen Intern Med 2019 Apr 22. Epub 2019 Apr 22.

Department of Medicine, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA.

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http://dx.doi.org/10.1007/s11606-019-04934-7DOI Listing

Quantitative assessment of exposure of heavy metals in groundwater and soil on human health in Reasi district, Jammu and Kashmir.

Environ Geochem Health 2019 Apr 22. Epub 2019 Apr 22.

Department of Chemistry, Centre for Advanced Studies, Guru Nanak Dev University, Amritsar, Punjab, 143001, India.

The assessment of heavy metal contents in environmental sectors is important to estimate the carcinogenic and non-carcinogenic doses and risks for the mankind associated with it. The present work deals with the assessment of the risk exposure related to heavy metal contents in groundwater and soil samples to two different age groups via three different transits, i.e. Read More

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http://link.springer.com/10.1007/s10653-019-00294-7
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http://dx.doi.org/10.1007/s10653-019-00294-7DOI Listing

Probucol Ameliorates Complete Freund's Adjuvant-Induced Hyperalgesia by Targeting Peripheral and Spinal Cord Inflammation.

Inflammation 2019 Apr 22. Epub 2019 Apr 22.

Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Brazil.

The effect of the lipid-lowering agent probucol in inflammatory hyperalgesia and leukocyte recruitment was evaluated in a model of subacute inflammation by Complete Freund's adjuvant (CFA). As CFA induces long-lasting nociception characterized by peripheral and spinal cord inflammation, the anti-inflammatory activity of probucol was assessed at both foci. Probucol at 0. Read More

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http://dx.doi.org/10.1007/s10753-019-01011-3DOI Listing

Pharmacokinetics of S-1 monotherapy in plasma and in tears for gastric cancer patients.

Int J Clin Oncol 2019 Apr 22. Epub 2019 Apr 22.

Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan.

Background: S-1 is an oral anticancer drug composed of tegafur (FT), which is a prodrug of 5-FU, 5-chloro-2,4-dihydroxypyridine (CDHP), and potassium oxonate. Recently, some studies have been reported on watering eyes caused by S-1. However, the mechanism of watering eyes caused by S-1 is still unclear. Read More

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http://link.springer.com/10.1007/s10147-018-01387-6
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http://dx.doi.org/10.1007/s10147-018-01387-6DOI Listing

Direct Oral Anticoagulants Versus Vitamin K Antagonists in Patients Undergoing Cardioversion for Atrial Fibrillation: a Systematic Review and Meta-analysis.

Cardiovasc Drugs Ther 2019 Apr 22. Epub 2019 Apr 22.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.

Background: Clinical guidelines recommend peri-cardioversion anticoagulation in patients with atrial fibrillation (AF). We performed a systematic review and meta-analysis to compare the safety and efficacy of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) in patients with AF undergoing cardioversion.

Methods: We searched CENTRAL, MEDLINE, and EMBASE for randomized controlled trials (RCTs) and observational studies comparing DOACs to VKAs in patients undergoing cardioversion for AF. Read More

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http://dx.doi.org/10.1007/s10557-019-06869-xDOI Listing
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