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Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting.

Alcohol 2018 Aug 24;77:11-18. Epub 2018 Aug 24.

Department of Surgery, Alcohol Research Program, Burn & Shock Trauma Research Institute, Loyola University Chicago Health Sciences Division, Maywood, IL, United States. Electronic address:

On January 26, 2018, the 23rd annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at the University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado. The meeting consisted of plenary sessions with oral presentations and a poster presentation session. There were four plenary sessions that covered a wide range of topics relating to alcohol use: Alcohol and Liver Disease; Alcohol, Inflammation and Immune Response; Alcohol and Organ Injury; Heath Consequences and Alcohol Drinking. Read More

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http://dx.doi.org/10.1016/j.alcohol.2018.08.010DOI Listing

Development and characterization of nanostructured lipid carrier-based gels for the transdermal delivery of donepezil.

Colloids Surf B Biointerfaces 2019 Feb 6;177:274-281. Epub 2019 Feb 6.

Pharmaceutical Sciences Faculty, Federal University of Alfenas, Gabriel Monteiro da Silva, 700. Zip code 37130-001, Alfenas, Minas Gerais, Brazil. Electronic address:

Donepezil is one of the main compounds used in the therapy of Alzheimer's disease. Oral administration of this drug presents many drawbacks, resulting in treatment non-adherence among patients. Thus, the development of transdermal formulations for donepezil delivery is important. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.007DOI Listing
February 2019

An evaluation of the gliding performance of solid oral dosage form film coatings using an artificial mucous layer.

Colloids Surf B Biointerfaces 2019 Feb 6;177:235-241. Epub 2019 Feb 6.

Graz University of Technology, Inffeldgasse 13, 8010 Graz, Austria; Lonza, Rijksweg 11, 2880 Bornem, Belgium. Electronic address:

Oral drug delivery technology is mainly provided in the form of solid oral dosage forms (SODF) that have to be swallowed intact and move throughout the oro-esophageal system to release the drug content in the stomach or intestine. As there is growing evidence for an increasing prevalence of impaired swallowing functions in certain diseases, multimorbidity and advanced age, predictive in vitro methods for the oro-esophageal gliding behavior of SODF would be very useful. The gliding performance of different SODF polymer films was investigated across an artificial mucous layer using a versatile in vitro gliding system. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.012DOI Listing
February 2019

Maxillary shape after primary cleft closure and before alveolar bone graft in two different management protocols: a comparative morphometric study.

J Stomatol Oral Maxillofac Surg 2019 Feb 11. Epub 2019 Feb 11.

Assistance Publique Hôpitaux de Paris, Hôpital Universitaire Necker Enfants Malades, Service de chirurgie maxillo-faciale et chirurgie plastique, Université Paris Descartes, Université Sorbonne Paris Cité, Paris, France. Electronic address:

Aim And Scope: Result assessment in cleft surgery is a technical challenge and requires the development of dedicated morphometric tools. Two cohorts of patients managed according to two different protocols were assessed at similar ages and their palatal shape was compared using geometric morphometrics. Material and Methods Ten patients (protocol №1) benefited from early lip closure (1-3 months) and secondary combined soft and hard palate closure (6-9 months); 11 patients (protocol №2) benefited from later combined lip and soft palate closure (6 months) followed by hard palate closure (18 months). Read More

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http://dx.doi.org/10.1016/j.jormas.2019.02.001DOI Listing
February 2019

Dental Implants in a Patient with Left Mandibular Fibrous Dysplasia: Two-Year Outcomes on the Normal and Affected Sides.

J Stomatol Oral Maxillofac Surg 2019 Feb 11. Epub 2019 Feb 11.

Oral and Maxillofacial surgery department, Rouen university hospital, 1 Rue de Germont, F-76031 Rouen, France; Laboratory of Anatomy, Rouen Faculty of Medicine, 22 Boulevard Léon-Gambetta, F-76031 Rouen, France; French National Institute for Health (INSERM), LIMICS UMR-1142, F-76031 Rouen, France.

Dental rehabilitation raises specific challenges in patients with mandibular fibrous dysplasia. We report the 2-year post-operative outcomes on the normal and affected sides in a 64-year-old female with focal left mandibular fibrous dysplasia and bilateral posterior edentulism. On the left, bone shaving of the lesion to restore sufficient vertical height was followed by the insertion of two dental implants. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.02.005DOI Listing
February 2019

Quality of Life Related to Oral Health and its Impact in Adults.

J Stomatol Oral Maxillofac Surg 2019 Feb 11. Epub 2019 Feb 11.

MD DDS, PhD. Doctor, Specialist in Stomatology. Professor of Oral Pathology, Faculty of Medicine and Health Sciences (School of Dentistry), Oral Health and Masticatory System Group (Bellvitge Biomedical Research Institute), IDIBELL, University of Barcelona, Departament of OdontoestomatologySecond Floor, Room 2.32, Faculty of Medicine and Health Sciences - School of Dentistry Campus Bellvitge, University of Barcelona, Spain.

Oral health is part of general health, and is recognized as an essential component of quality of life (QoL). For years, oral health was determined solely by the clinic, which did not allow an evaluation of the true impact of oral diseases on the patients' daily lives. The development of instruments for assessing QoL related to oral health has occurred due to the urgency of determining the effects of changes in the oral cavity of individuals. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.02.004DOI Listing
February 2019

CHIMERIC TEMPOROPAREITAL OSTEOFASCIAL AND TEMPORALIS MUSCLE FLAP; A NOVEL METHOD FOR THE RECONSTRUCTION OF COMPOSITE ORBITO-MAXILLARY DEFECTS.

J Stomatol Oral Maxillofac Surg 2019 Feb 11. Epub 2019 Feb 11.

Consultant, Division of Oral and Maxillofacial Surgery, Army Dental Centre (Research & Referral), New Delhi, India.

Reconstruction of midface defects are extremely challenging owing to the lack of suitable vascularized local flaps. The temporoparietal fascia and temporalis muscle flaps make excellent choices for midface and orbito-maxillary reconstruction. The muscle provides adequate thickness while the fascia yields pliable soft tissues for lining the midface. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.02.002DOI Listing
February 2019

Bilateral auricular reconstruction with osseointegrated implant-retained prostheses. Optimization of aesthetic outcomes using virtual planning.

J Stomatol Oral Maxillofac Surg 2019 Feb 11. Epub 2019 Feb 11.

Complejo Hospitalario Universitario Virgen de las Nieves, Granada, Spain. Electronic address:

Auricular reconstruction in microtia patients is challenging, particularly in bilateral cases. The use of osseointegrated implants is a safe and effective way to retain the auricular prostheses. With the help of virtual planning we can produce more predictable results with better aesthetic outcomes. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.02.003DOI Listing
February 2019

Vascularization of the maxilla by a branch of the submandibular artery.

J Stomatol Oral Maxillofac Surg 2019 Feb 11. Epub 2019 Feb 11.

Centre hospitalier Intercommunal, Chirurgie Maxillo-faciale, Villeneuve Saint Georges 94195, France; CHU Bouaké, Bouaké, Ivory Coast.

Vascular variations are common. A cervicofacial anatomical dissection carried out at the anatomy laboratory allowed us to document a rare vascular variation. The facial artery did not give rise to branches that led to the submandibular gland; an artery arising directly from the external carotid artery vascularized the submandibular gland and gave rise to the ascending palatine artery that led to the maxilla. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.01.015DOI Listing
February 2019

clinical evaluation of submental intubation as an alternative airway management technique in midface osteotomy.

J Stomatol Oral Maxillofac Surg 2019 Feb 11. Epub 2019 Feb 11.

Post Graduate Student Department Of Oral & Maxillofacial Surgery, K.V.G. Dental College & Hospital, Sullia, Karnataka, India.

Background: The conventional endonasal intubation would not allow precise intra-operative assessment of the changes to the nasolabial soft tissue complex. Submental intubation allows accurate measurement of nasolabial soft tissue complex with no interference with the occlusion.

Methodology: A clinical prospective study was carried on 20 patients visiting the Oral & Maxillofacial Surgery department diagnosed of dentofacial deformity requiring orthognathic surgery. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.01.014DOI Listing
February 2019

Colonic adenoma-associated Escherichia coli express specific phenotypes.

Microbes Infect 2019 Feb 11. Epub 2019 Feb 11.

Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy; Dani Di Giò Foundation-Onlus, Rome, Italy. Electronic address:

Specific Escherichia coli strains have been associated to colorectal cancer, while no data are available on genotypic and phenotypic features of E. coli colonizing premalignant adenomatous polyps and their pathogenic potential. This study was aimed at characterizing isolates collected from polyps and adjacent tissue in comparison with those from normal mucosa. Read More

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http://dx.doi.org/10.1016/j.micinf.2019.02.001DOI Listing
February 2019

Porphyromonas gingivalis promotes the motility of esophageal squamous cell carcinoma by activating NF-κB signaling pathway.

Microbes Infect 2019 Feb 11. Epub 2019 Feb 11.

Guangdong Provincial Institute of Geriatrics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China; Department of Gastroenterology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address:

Esophageal carcinoma, with a increasing incidence, is one of the most aggressive carcinomas in gastrointestinal tract. Epidemiologic studies demonstrate an association of oral pathogens with multiple diseases, including rheumatoid arthritis, cardiovascular diseases, diabetes, and gastrointestinal malignancies. Nevertheless, a causal relationship between oral pathogens and esophageal squamous cell carcinoma (ESCC) has not been elucidated. Read More

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http://dx.doi.org/10.1016/j.micinf.2019.01.005DOI Listing
February 2019

Retrosigmoid intradural suprajugular approach to jugular foramen tumors with intraforaminal extension: surgical series of 19 cases.

World Neurosurg 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurosurgery, Tokyo Metropolitan Police Hospital, #4-22-1, Nakano, Nakano-ku, Tokyo, 164-8541, Japan.

Objective: The intraforaminal component of jugular foramen tumors is difficult to access surgically, as it requires complex approaches for radical removal and leads to a high recurrence due to residual tumor. The retrosigmoid suprajugular approach, intradural drilling of the roof of the jugular foramen, has been recently proposed for removal of such intraforaminal component without sacrificing the sigmoid-jugular venous system or requiring additional approaches. This study presents our experience with this approach and introduces the utility of intraoperative continuous vagus nerve monitoring. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.223DOI Listing
February 2019

Modified oral enteric-coated budesonide regimens to treat pediatric eosinophilic gastroenteritis, a single center experience.

J Allergy Clin Immunol Pract 2019 Feb 11. Epub 2019 Feb 11.

Division of Allergy and Immunology, Children's Hospital of Philadelphia; Department of Pediatrics, Perelman School of Medicine at The University of Pennsylvania.

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http://dx.doi.org/10.1016/j.jaip.2019.01.053DOI Listing
February 2019

Osimertinib plus durvalumab versus osimertinib monotherapy in EGFR T790M-positive NSCLC following previous EGFR-TKI therapy: CAURAL brief report.

J Thorac Oncol 2019 Feb 11. Epub 2019 Feb 11.

Thoracic Oncology Program, Vanderbilt University Medical Center, Nashville, TN, USA.

Introduction: Osimertinib is a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). Durvalumab is an anti-PD-L1 monoclonal antibody. The Phase III open-label CAURAL trial (NCT02454933) investigated osimertinib plus durvalumab versus osimertinib monotherapy in patients with EGFR-TKI sensitizing and T790M mutation-positive advanced non-small cell lung cancer (NSCLC) and disease progression following EGFR-TKI therapy. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.02.001DOI Listing
February 2019

An enigmatic case of an uncommon syndrome: the Hughes-Stovin syndrome.

Ann Vasc Surg 2019 Feb 11. Epub 2019 Feb 11.

Department of Vascular and Endovascular Surgery, University Hospital Frankfurt am Main, Germany. Electronic address:

Hughes-Stovin syndrome is a disorder characterized by deep vein thrombosis and pulmonary artery aneurysms with potentially life-threatening complications. The case of a 22-year-old Moroccan male patient, presenting with signs of sepsis of unclear etiology, is presented here. CT scan revealed thrombosis of the inferior vena cava up to the hepatic veins, thrombosis of both common iliac veins and a thrombus in the right atrium. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.11.018DOI Listing
February 2019

Acid diterpenes from copaiba oleoresin (Copaifera langsdorffii): chemical and plasma stability and intestinal permeability using Caco-2 cells.

J Ethnopharmacol 2019 Feb 11. Epub 2019 Feb 11.

São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil, ZIP 14801-902. Electronic address:

Ethnopharmacological Relevance: Copaiba oleoresin has been used in folk medicine in the treatment of bronchitis, syphilis, skin diseases and ulcers due to its anti-inflammatory and antiseptic activities, but there is no information about major compounds oral absorption to support the traditional use.

Aim Of Study: Considering the potential of copalic (CA) and kaurenoic acid (KA) - major biological activity (in vitro) diterpenes found in the oleoresin, this study aimed to evaluate the intestinal permeability of CA and KA using Caco-2 cells model as predictive test for oral drug absorption.

Materials And Methods: Chemical stability at pH 1. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.017DOI Listing
February 2019

Can the gastric healing effect of Eugenia punicifolia be the same in male and female rats?

J Ethnopharmacol 2019 Feb 11. Epub 2019 Feb 11.

Department of Physiology, Biosciences Institute, UNESP-São Paulo State University CEP 18618-689, Botucatu, São Paulo, Brazil. Electronic address:

Ethnopharmacological Relevance: Eugenia punicifolia (Kunth) DC. (Myrtaceae), an Amazonian medicinal plant known as "pedra-ume-caá," is popularly used as a natural remedy for inflammation, wounds, infections, diabetes, fever, and flu. Its anti-inflammatory, antinociceptive, and gastroprotective effects have already been characterized. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.012DOI Listing
February 2019

In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.

J Ethnopharmacol 2019 Feb 11. Epub 2019 Feb 11.

Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610, Antwerp, Belgium.

Ethnopharmacological Relevance: An aqueous decoction of root bark of Alstonia congensis Engl. (Apocynaceae) is used in several African countries to treat various ailments including malaria.

Materials And Methods: Extracts of different polarity and isolated constituents were tested in vitro for their antiplasmodial activity against the chloroquine-resistant strain Plasmodium falciparum K1 and the chloroquine-sensitive strain P. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.019DOI Listing
February 2019

Crocus sativus by-products as sources of bioactive extracts: Pharmacological and toxicological focus on anthers.

Food Chem Toxicol 2019 Feb 11. Epub 2019 Feb 11.

Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti, Italy.

Multiple studies revealed the potential application of high quality saffron byproducts as cheap sources of bioactive compounds endowed with antioxidant activity. In the present study, we analyzed the total fatty acids of the anthers, and explored the pharmacological and toxicological potential of anthers, by evaluating genotoxic and protective effects in multiple cell lines, brine shrimps and isolated rat tissues. The phytochemical analyses showed that anthers are rich in long chain fatty acids most of which are unsaturated (80. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.040DOI Listing
February 2019

Orexin facilitates GABAergic IPSCs via postsynaptic OX receptors coupling to the intracellular PKC signalling cascade in the rat cerebral cortex.

Neuropharmacology 2019 Feb 11. Epub 2019 Feb 11.

Department of Pharmacology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan; Division of Oral and Craniomaxillofacial Research, Dental Research Centre, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan; Molecular Dynamics Imaging Unit, RIKEN Centre for Life Science Technologies, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, 650-0047, Japan. Electronic address:

Orexin has multiple physiological functions including wakefulness, appetite, nicotine intake, and nociception. The cerebral cortex receives abundant orexinergic projections and expresses both orexinergic receptor 1 (OXR) and 2 (OXR). However, little is known about orexinergic regulation of GABA-mediated inhibitory synaptic transmission. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.02.012DOI Listing
February 2019

F5-peptide enhances the efficacy of the non-hormonal male contraceptive adjudin.

Contraception 2019 Feb 11. Epub 2019 Feb 11.

The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Ave, New York, NY 10065. Electronic address:

Objective: The bioavailability of the non-hormonal male contraceptive adjudin is low in rats due to the blood-testis barrier (BTB). This study was designed to examine if F5-peptide, an endogenously produced reversible BTB modifier, could enhance the bioavailability of adjudin to affect spermatogenesis and provide a contraceptive effect in rats while reducing systemic toxicity.

Study Design: We overexpressed F5-peptide in adult male rats (n=10 rats; with 3 or 4 rats for each of the three different experiments noted in the three regimens) by intratesticular injection of a mammalian expression vector pCI-neo (pCI-neo/F5-peptide) vs. Read More

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http://dx.doi.org/10.1016/j.contraception.2019.01.007DOI Listing
February 2019

Claims for contraceptive services among young women filling chronic opioid prescriptions.

Contraception 2019 Feb 11. Epub 2019 Feb 11.

Division of Pharmaceutical Evaluation and Policy, Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address:

Objective: To describe claims for contraceptive services among reproductive aged women filling chronic opioid prescriptions.

Study Design: Using a large US commercial claims database, IMS Lifelink+, we identified women aged 15-44years who filled chronic opioid prescriptions (defined as a 90day supply of opioids without a 30day gap over a 180day time period) and had continuous pharmacy and medical enrollment for at least 90days prior to and 180days following their index opiod prescription. After excluding women with any claims for pregnancy-related services, we describe claims for contraceptive prescriptions and used multivariable logistic regression to identify variables associated with women filling chronic opioids without any contraceptive claims. Read More

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http://dx.doi.org/10.1016/j.contraception.2019.01.004DOI Listing
February 2019

Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors.

Cell Host Microbe 2019 Feb;25(2):324-335.e4

Children's Hospital Research Institute of Manitoba, Pediatrics and Child Health, Winnipeg, MB, Canada; Developmental Origins of Chronic Diseases in Children Network (DEVOTION), Winnipeg, MB, Canada. Electronic address:

Breastmilk contains a complex community of bacteria that may help seed the infant gut microbiota. The composition and determinants of milk microbiota are poorly understood. Among 393 mother-infant dyads from the CHILD cohort, we found that milk microbiota at 3-4 months postpartum was dominated by inversely correlated Proteobacteria and Firmicutes, and exhibited discrete compositional patterns. Read More

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http://dx.doi.org/10.1016/j.chom.2019.01.011DOI Listing
February 2019

Titanium Lag Screw Versus Miniplate Fixation in the Treatment of Anterior Mandibular Fractures.

J Oral Maxillofac Surg 2019 Jan 15. Epub 2019 Jan 15.

Resident and Postdoctoral Researcher, Departments of Periodontics and Endodontics and Oral Biology, School of Dental Medicine, SUNY Buffalo, Buffalo, NY.

Purpose: The use of plates for open reduction and internal fixation of mandibular fractures has become a widely accepted method in the past 3 decades. However, the anterior mandible is well suited to lag screw fixation owing to the thickness of its bony cortices. Hence, the purpose of the present study was to comparatively evaluate clinical outcomes of fixation using lag screws and miniplates in anterior mandibular fractures. Read More

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http://dx.doi.org/10.1016/j.joms.2019.01.001DOI Listing
January 2019

[Fatal Toxic Epidermal Necrolysis Induced by Diclofenac Re-Administration in the Teaching Hospital of Bouaké (Côte d'Ivoire)].

Bull Soc Pathol Exot 2018 ;111(1):9-11

Service d'anesthésie-réanimation, CHU de Bouaké, BP 1174 Bouaké, Côte d'Ivoire.

Lyell's syndrome or toxic epidermal necrolysis is an acute and severe cutaneous adverse drug reaction with a significant morbidity and mortality. It is a very rare condition but a vital emergency with a poor prognosis. The diagnosis is clinical and confirmed by a cutaneous biopsy showing a necrosis of the epidermis. Read More

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http://dx.doi.org/10.3166/bspe-2018-0009DOI Listing
January 2018

Gingipains impair attachment of epithelial cell to dental titanium abutment surfaces.

J Biomed Mater Res B Appl Biomater 2019 Feb 14. Epub 2019 Feb 14.

Department of Periodontology, Faculty of Odontology, Malmö University, Malmö, Sweden.

The study investigated in vitro the effect of Porphyromonas gingivalis and its cysteine proteases (gingipains) on epithelial cell adhesion to titanium-zirconium alloy surfaces. Titanium-zirconium discs with a standard machined (M) or chemically modified hydrophilic surface (modM) were coated with lamin-5 and incubated with telomerase-inactivated gingival keratinocytes (TIGK). Three P. Read More

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http://dx.doi.org/10.1002/jbm.b.34345DOI Listing
February 2019

Racial and ethnic disparities in medication adherence among privately insured patients in the United States.

PLoS One 2019 14;14(2):e0212117. Epub 2019 Feb 14.

Department of Pharmaceutical & Health Economics, USC School of Pharmacy, Los Angeles, California, United States of America.

Objective: To examine the association between socioeconomic status (SES) and racial and ethnic disparities in medication adherence for three widely prescribed therapeutic classes.

Methods: We linked longitudinal claims data from a large US-based insurance provider (2011-2013) to detailed SES information to identify patients treated with oral antidiabetic (N = 56,720), antihypertensive (N = 156,468) or antihyperlipidemic (N = 144,673) medications. We measured adherence and discontinuation by therapeutic class, and conducted regression analysis to quantify the contributions of different factors in the association between race/ethnicity and medication adherence. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212117PLOS
February 2019

A prescription support-tool for chronic management of oral antithrombotic combinations in adults based on a systematic review of international guidelines.

PLoS One 2019 14;14(2):e0211695. Epub 2019 Feb 14.

Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpital Pitié-Salpêtrière, Département Biostatistique Santé Publique et Information Médicale, Unité de Recherche Clinique PSL-CFX, Centre de Pharmacoépidémiologie (Cephepi), Paris, France.

Background: Oral antithrombotic (AT) drugs, which include antiplatelet and anticoagulant therapies, are widely implicated in serious preventable bleeding events. Avoiding inappropriate oral AT combinations is a major concern. Numerous practical guidelines have been released; a document to enhance prescriptions of oral AT combinations for adults would be of great help. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211695PLOS
February 2019

Recommendations of the Advisory Committee on Immunization Practices for Use of Hepatitis A Vaccine for Persons Experiencing Homelessness.

MMWR Morb Mortal Wkly Rep 2019 Feb 15;68(6):153-156. Epub 2019 Feb 15.

Hepatitis A (HepA) vaccination is recommended routinely for children at age 12-23 months, for persons who are at increased risk for hepatitis A virus (HAV) infection, and for any person wishing to obtain immunity. Persons at increased risk for HAV infection include international travelers to areas with high or intermediate hepatitis A endemicity, men who have sex with men, users of injection and noninjection drugs, persons with chronic liver disease, person with clotting factor disorders, persons who work with HAV-infected primates or with HAV in a research laboratory setting, and persons who anticipate close contact with an international adoptee from a country of high or interme-diate endemicity (1-3). Persons experiencing homelessness are also at higher risk for HAV infection and severe infection-associated outcomes. Read More

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http://www.cdc.gov/mmwr/volumes/68/wr/mm6806a6.htm?s_cid=mm6
Publisher Site
http://dx.doi.org/10.15585/mmwr.mm6806a6DOI Listing
February 2019
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The effect of DOAC-Stop on lupus anticoagulant testing in plasma samples of venous thromboembolism patients receiving direct oral anticoagulants.

Clin Chem Lab Med 2019 Feb 14. Epub 2019 Feb 14.

Institute of Cardiology, Jagiellonian University Medical College and John Paul II Hospital, Krakow, Poland.

Background Direct oral anticoagulants (DOACs) cause false positive lupus anticoagulant (LA) results. We assessed the impact of DOAC-Stop, reversing in vitro effects of DOACs, on LA testing in anticoagulated patients. Methods We assessed 75 venous thromboembolism patients aged 44. Read More

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http://dx.doi.org/10.1515/cclm-2018-1197DOI Listing
February 2019

Managing Drug Interactions With Oral Anticancer Agents: Signals, Noise, and Echoes.

Authors:
R Donald Harvey

J Oncol Pract 2019 Feb;15(2):91-92

1 Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, GA.

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http://dx.doi.org/10.1200/JOP.18.00721DOI Listing
February 2019

Oral Anticancer Therapy: Management of Drug Interactions.

J Oncol Pract 2019 Feb;15(2):81-90

5 Allegheny Health Network, Pittsburgh, PA.

Oral anticancer therapy is increasingly integrated into the care of patients with cancer. Recognition and management of drug-drug interactions (DDIs) is critical to providing efficacious and safe anticancer treatment. DDIs with QTc-prolonging agents, anticoagulants, enzyme inducers and inhibitors, antidepressants, and acid suppressants are commonly encountered with anticancer therapies. Read More

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http://dx.doi.org/10.1200/JOP.18.00483DOI Listing
February 2019

Oral Immunotherapy for Peanut Allergy.

Authors:

N Engl J Med 2019 Feb;380(7):690-692

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http://dx.doi.org/10.1056/NEJMc1817331DOI Listing
February 2019

Respiratory system reactance reflects communicating lung volume in chronic obstructive pulmonary disease.

J Appl Physiol (1985) 2019 Feb 14. Epub 2019 Feb 14.

Respiratory Medicine, Woolcock Institute, University of Sydney, Australia.

Respiratory system reactance (Xrs) measured by the forced oscillation technique (FOT) is theoretically and experimentally related to lung volume. In chronic obstructive pulmonary disease (COPD), the absolute volume measured by body plethysmography includes a proportion which is inaccessible to pressure oscillations applied via the mouth - that is, a 'non-communicating' lung volume. We hypothesized that, in COPD, the presence of non-communicating lung would disrupt the expected Xrs-volume relationship when compared to plethysmographic functional residual capacity (FRC). Read More

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http://dx.doi.org/10.1152/japplphysiol.00503.2018DOI Listing
February 2019

Manipulative Therapies: What Works.

Am Fam Physician 2019 Feb;99(4):248-252

University of Florida, Gainesville, FL, USA.

Manipulative therapies include osteopathic manipulative treatment and many other forms of manual therapies used to manage a variety of conditions in adults and children. Spinal manipulative therapy may provide short-term improvement in patients with acute or chronic low back pain, comparable with other standard treatments. When compared with oral analgesics, cervical manipulation and/or mobilization appears to provide better short-term pain relief and improved function in patients with neck pain. Read More

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February 2019

Acute Hand Infections.

Am Fam Physician 2019 Feb;99(4):228-236

U.S. Marine Corps School of Infantry-East, Camp Geiger, NC, USA.

Acute hand infections are often caused by puncture wounds and are generally classified into superficial or deep infections. Superficial infections occur in the skin and subcutaneous tissues, whereas deep infections can involve the tendon sheaths, adjacent anatomic compartments, deep fascial planes, bursae, joint spaces, and bones. Superficial hand infections are more common than deep infections and are typically managed with elevation, warm soaks, splinting in the position of function, analgesics, and empiric antibiotics when indicated. Read More

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February 2019

[Management of childhood food allergies].

Rev Med Suisse 2019 Feb;15(638):398-401

Unité d'allergologie pédiatrique, HUG, 1211 Genève 14.

Food allergy reduces the quality of allergic children life because of a lethal risk. Current recommendations are favouring introduction of potentially allergenic foods according to usual, non-delayed, practices. In allergic children, intramuscular epinephrine is the key treatment of anaphylaxis. Read More

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February 2019

[Iron deficiency with and without anemia in children: a brief update for caregivers].

Rev Med Suisse 2019 Feb;15(638):376-381

Service de pédiatrie, Département femme-mère-enfant, CHUV, 1011 Lausanne.

Non anemic iron deficiency (NAID) is the most common nutritional deficiency. Symptoms more frequently observed in children and adolescents include fatigue, delayed psychomotor development as well as decreased school and athletic performances. Iron treatment is effective in improving symptoms in older children and adolescents. Read More

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February 2019

S2k Guidelines for Cutaneous Basal Cell Carcinoma - Part 2: Treatment, Prevention and Follow-up.

J Dtsch Dermatol Ges 2019 Feb;17(2):214-230

Department of Dermatology, Mainz University Medical Center, Mainz, Germany.

Basal cell carcinoma (BCC) is the most common malignant tumor among fair-skinned individuals, and its incidence had been steadily rising in the past decades. In order to maintain the highest quality of patient care possible, the German S2k guidelines were updated following a systematic literature search and with the participation of all professional societies and associations involved in the management of the disease. Part 2 addresses issues such as proper risk stratification, the various therapeutic approaches, and prevention as well as follow-up of patients with basal cell carcinoma. Read More

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http://dx.doi.org/10.1111/ddg.13755DOI Listing
February 2019

Jamun (Eugenia jambolana Lam.) Fruit Extract Prevents Obesity by Modulating the Gut Microbiome in High-Fat Diet-Fed Mice.

Mol Nutr Food Res 2019 Feb 14:e1801307. Epub 2019 Feb 14.

J. Xu, T. Liu, Y. Li, W. Liu, Z. Ding, Y. Mu1, X. Huang, and L. Li, Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, 110169, P. R. China.

Scope: Published data support that gut microbiota play an important role in the pathological process of obesity and related metabolic disorders. In the current study, we investigated whether a standardized extract from Jamun (Eugenia jambolana), a widely consumed tropical fruit, could alleviate obesity and alter gut microbial community in high-fat diet (HFD)-fed mice.

Methods And Results: C57BL/6 mice were fed either a standard diet (SD) or HFD with or without Jamun fruit extract (JFE; 100 mg/kg/day) by oral gavage for 8 weeks. Read More

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http://dx.doi.org/10.1002/mnfr.201801307DOI Listing
February 2019

secreted Frizzled-Related Protein 5 Serum Levels in Human Periodontitis - a nested case-control study.

J Clin Periodontol 2019 Feb 14. Epub 2019 Feb 14.

Department of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Aim: Recombinant secreted frizzled-related protein 5 (sFRP5) improved periodontal status in mice. Thus, this study aimed to investigate this finding in human periodontitis using an epidemiological approach.

Materials And Methods: sFRP5 and wnt5a concentrations were determined in human serum from the Food Chain Plus cohort using ELISAs. Read More

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http://dx.doi.org/10.1111/jcpe.13087DOI Listing
February 2019

JAK inhibitors for alopecia areata: a systematic review and meta-analysis.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, Liverpool Hospital, Sydney, Australia.

Background: There have been a number of case reports and small clinical trials reporting promising outcomes of JAK inhibitors tofacitinib, ruxolitinib, and baracitinib for alopecia areata (AA). The majority of the literature to date is based on small volume data, with a lack of definitive evidence or guidelines.

Objective: To determine the expected response of AA to JAK inhibitor therapy, and factors which influence response and recurrence rates. Read More

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http://dx.doi.org/10.1111/jdv.15489DOI Listing
February 2019

Acute generalized exanthematous pustulosis induced by iomeprol with cross-reactivity to other iodinated contrast agents and mild reaction after rechallenge with iopromide and oral corticosteroid premedication.

Contact Dermatitis 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, University of Tours, France.

Immediate hypersensitivity reactions to iodinated contrast media (ICM) are rare and occur within 1 hour after infusion, but also up to 7 days later. This article is protected by copyright. All rights reserved. Read More

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http://dx.doi.org/10.1111/cod.13242DOI Listing
February 2019

Effects of therapeutic plasma exchange on anticoagulants in patients receiving therapeutic anticoagulation: a systematic review.

Transfusion 2019 Feb 14. Epub 2019 Feb 14.

Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.

Therapeutic plasma exchange (TPE) removes coagulation proteins, but its impact on therapeutic anticoagulation is unknown. We performed a systematic review of the literature to determine the coagulation effects of TPE in patients receiving systemic anticoagulation. We searched MEDLINE, CINAHL, EMBASE, and Web of Science until June 2018 for studies combining controlled vocabulary and keywords related to therapeutic plasma exchange, plasmapheresis, anticoagulants, and therapy. Read More

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http://dx.doi.org/10.1111/trf.15191DOI Listing
February 2019

Kawasaki disease complicating bilateral facial nerve palsy and giant coronary artery aneurysms: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14395

The First Hospital of Jilin University, Changchun.

Rationale: Kawasaki disease (KD), which is also known as mucocutaneous lymphnode syndrome, is a vasculitic disease and involves multi-system disorder with various clinical manifestations. KD is specific predilection for the coronary arteries and is the most common cause of childhood-acquired heart disease in developed countries. KD is rarely complicated by cranial nerve VII palsy. Read More

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http://dx.doi.org/10.1097/MD.0000000000014395DOI Listing
February 2019

Be aware of the effects of glucocorticoids on SIADH: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14295

Department of Endocrinology, Affiliated Hospital of Guangdong Medical University, Guangdong Province, China.

Rationale: Hyponatremia is one of the most common electrolyte disorders in clinic. Due to the complicated etiology and the nonspecific clinical manifestations, the diagnosis of hyponatremia is a complicated process. A variety of clinical disorders can cause inappropriately increased antidiuretic hormone (ADH) secretion, leading to inappropriate water retention and consequent hyponatremia. Read More

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http://dx.doi.org/10.1097/MD.0000000000014295DOI Listing
February 2019

What Pain Levels Do TSA Patients Experience When Given a Long-acting Nerve Block and Multimodal Analgesia?

Clin Orthop Relat Res 2019 Mar;477(3):622-632

J. T. YaDeau, S. S. Liu, M. A. Gordon, E. A. Goytizolo, Y. Lin, A. A. Schweitzer, Department of Anesthesiology, Critical Care and Pain Management Hospital for Special Surgery, New York, NY, USA D. M. Dines, L. V. Gulotta, Department of Orthopedic Surgery, Sports Medicine, Hospital for Special Surgery, New York, NY, USA K. G. Fields, Healthcare Research Institute, Hospital for Special Surgery, New York, NY, USA.

Background: The pain experience for total shoulder arthroplasty (TSA) patients in the first 2 weeks after surgery has not been well described. Many approaches to pain management have been used, with none emerging as clearly superior; it is important that any approach minimizes postoperative opioid use.

Questions/purposes: (1) With a long-acting nerve block and comprehensive multimodal analgesia, what are the pain levels after TSA from day of surgery until postoperative day (POD) 14? (2) How many opioids do TSA patients take from the day of surgery until POD 14? (3) What are the PainOUT responses at POD 1 and POD 14, focusing on side effects from opioids usage?

Methods: From January 27, 2017 to December 6, 2017, 154 TSA patients were identified as potentially eligible for this prospective, institutional review board-approved observational study. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000597DOI Listing

Use of direct oral anticoagulants in very elderly patients: a case report of apixaban in an ultracentenary patient.

J Cardiovasc Med (Hagerstown) 2019 Feb 11. Epub 2019 Feb 11.

Department of Emergency and Urgency, Biomedic Department of Internal Medicine and Specialities (DIBIMIS).

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http://dx.doi.org/10.2459/JCM.0000000000000752DOI Listing
February 2019

The Incidence of Pin Tract Infections and Septic Arthritis in Percutaneous Distal Femur Pinning.

J Pediatr Orthop 2019 Feb 11. Epub 2019 Feb 11.

Children's Orthopaedic Center, Children's Hospital Los Angeles, Los Angeles, CA.

Background: Retrograde percutaneous pinning often involves intra-articular pin placement. Classic teaching has cautioned about the risk of septic arthritis with intra-articular pins, although an incidence has not been reported for this complication. The purpose of this study was to determine the incidence of pin tract infections and septic arthritis following retrograde percutaneous pinning of the distal femur. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001346DOI Listing
February 2019
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