1,562 results match your criteria Oral Submucous Fibrosis


Predictors of the severity of oral submucous fibrosis among gutka consumers: a regression analysis.

Br J Oral Maxillofac Surg 2020 Sep 11. Epub 2020 Sep 11.

Oral and Maxillofacial Surgery Unit, Baqai Dental College, Karachi, Pakistan.

Oral submucous fibrosis (OSMF) is an insidious chronic disease of the oral mucosa that is characterised by severely limited mouth opening, blanching of the oral mucosa, and a burning sensation in the oral cavity. Consumption of betel nut and/or gutka are the known risk factors. We undertook this study to correlate the frequency and duration of gutka intake with the severity of OSMF and to determine the predictors of severe OSMF (mouth opening <20mm). Read More

View Article and Full-Text PDF
September 2020

Limited Evidence Suggests About One in Five Potentially Premalignant Oral Lesions Is Related to Human Papillomavirus.

Authors:
Linda L Cheng

J Evid Based Dent Pract 2021 Mar 2;21(1):101531. Epub 2021 Feb 2.

Article Title And Bibliographic Information: Human papillomavirus prevalence in oral potentially malignant disorders: Systematic review and meta-analysis. de la Cour CD, Sperling CD, Belmonte F, Syrjänen S, Kjaer SK. Oral Dis. Read More

View Article and Full-Text PDF

Role of Yes-associated protein and transcriptional coactivator with PDZ-binding motif in the malignant transformation of oral submucous fibrosis.

Arch Oral Biol 2021 May 23;128:105164. Epub 2021 May 23.

Department of Oral Pathology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, 576104, India. Electronic address:

Objective(s): The objective of the present manuscript is to elucidate the role of matrix stiffness in the malignant transformation of oral submucous fibrosis.

Design: The role of matrix stiffness in several cancers including oral cancer was reviewed with a tailored search strategy using relevant keywords as per the Medline format. The role of molecular mediators, Yes-associated protein 1 (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) was weighed in the context of OSF along two distinct pathways. Read More

View Article and Full-Text PDF

Conspicuous and frank dilated vascular spaces: A marker of malignant transformation in oral submucous fibrosis.

J Oral Biol Craniofac Res 2021 Jul-Sep;11(3):365-367. Epub 2021 Mar 24.

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

Histo-morphological alterations observed at mucosal surgical margins can be envisaged as potential markers of malignant transformation. In this paper, we have presented a very striking observation at the mucosal surgical margins of oral squamous cell carcinoma arising in the background of oral submucous fibrosis (OSCC-OSMF). Out of 38 cases of OSCC-OSMF, 22 (57. Read More

View Article and Full-Text PDF

Role of coronoidectomy and temporalis myotomy in surgical management of oral submucous fibrosis.

Oral Maxillofac Surg 2021 May 15. Epub 2021 May 15.

Department of Oral pathology, SDM College of Dental Sciences and Hospital, A Constituent unit of Shri Dharmasthala Manjunatheshwara University, Dharwad, Karnataka, India.

Purpose: The involvement of temporalis muscle fibers by oral submucous fibrosis (OSMF) and the procedure of coronoidectomy and temporalis myotomy in the surgical treatment protocol for the disease is a controversy. The primary objective of this study is to evaluate the histopathological changes in temporalis muscle fibers in patients undergoing surgical treatment for OSMF and to authenticate the importance of temporalis myotomy and coronoidectomy in surgical treatment protocol.

Method: A 3-year prospective study was conducted to assess the histopathological changes in temporalis muscle in surgically treated OSMF cases. Read More

View Article and Full-Text PDF

Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor-β/Smad2/3 signaling inhibition.

J Formos Med Assoc 2021 May 9. Epub 2021 May 9.

School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan. Electronic address:

Background/purpose: The habit of areca nut chewing has been regarded as an etiological factor of precancerous oral submucous fibrosis (OSF). In the present study, we aimed to evaluate the anti-fibrosis effect of honokiol, a polyphenolic component derived from Magnolia officinalis.

Methods: The cytotoxicity of honokiol was tested using normal and fibrotic buccal mucosal fibroblasts (fBMFs) derived from OSF tissues. Read More

View Article and Full-Text PDF

Oral submucous fibrosis: An overview of a challenging entity.

Indian J Dermatol Venereol Leprol 2021 Apr 23:1-10. Epub 2021 Apr 23.

Department of Oral Pathology and Microbiology & Forensic Odontology, Luxmibai Institute of Dental Sciences and Hospital, Patiala, Punjab, India.

The oral cavity is considered to be a mirror of the body's health, as it reflects the manifestations of various systemic disorders. Most of the oral mucosa is derived embryologically from an invagination of ectoderm and thus, like other similar orifices, it may become involved in the disorders that are primarily associated with the skin. Oral submucous fibrosis is one of the commonest precancerous conditions of the oral mucosa involving any part of the oral cavity resulting in tissue scarring, dysphagia and trismus. Read More

View Article and Full-Text PDF

Morphometric analysis of basal cells of oral epithelium in predicting malignant transformation of oral potentially malignant disorders in patients with tobacco chewing habit.

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):579. Epub 2021 Jan 9.

Department of Oral and Maxillofacial Pathology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.

Background: Oral potentially malignant disorders (OPMDs) are a heterogenous group of disorders which precede the development of oral cancer. These are characterized by increased risk of malignant transformation to Oral cancer.

Aims & Objectives: In this study, an attempt has been made to assess the morphological alterations of the nuclei of the basal cells in OPMDs and oral squamous cell carcinoma (OSCC). Read More

View Article and Full-Text PDF
January 2021

Evaluation of Hematological profile in Oral Submucous Fibrosis: A Cross-sectional Study.

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):575. Epub 2021 Jan 9.

Department of Oral Medicine and Radiology, Manubhai Patel Dental College, Hospital and Oral Research Institute, Vadodara, Gujarat, India.

Aims: The purpose of this study was to estimate hemoglobin (Hb) level, red cell indices (RCIs), serum iron level and Vitamin B12 level in patients with oral submucous fibrosis (OSMF) and to analyze the association of these parameters in different stages of OSMF.

Setting And Design: This case-control study comprised of 65 individuals, with 40 OSMF patients and 25 controls. The OSMF patients were graded clinically according to the classification by Arakeri . Read More

View Article and Full-Text PDF
January 2021

Immunohistochemical detection of 8-hydroxydeoxyguanosine: A biomarker of oxidative DNA damage in oral submucous fibrosis.

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):536-541. Epub 2021 Jan 9.

Department of Oral and Maxillofacial Surgery, Karpaga Vinayaga Institute of Dental Sciences, Chengalpattu, Tamil Nadu, India.

Background: Oral submucous fibrosis (OSMF) is one of the common potentially malignant disorders prevailing in India. The primary etiological factors include tobacco and arecanut, which contain numerous reactive oxygen species (ROS). ROS attack guanine bases in DNA and form 8-hydroxydeoxyguanosine (8-OHdG), which can be detected in patients who have diseases associated with oxidative stress. Read More

View Article and Full-Text PDF
January 2021

Silencing periostin inhibits myofibroblast transdifferentiation of fibrotic buccal mucosal fibroblasts.

J Formos Med Assoc 2021 May 5. Epub 2021 May 5.

School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address:

Background/purpose: Oral submucous fibrosis (OSF) a well-recognized oral premalignant disorder. Several studies have demonstrated that periostin, a matricellular protein, is involved in the development and pathogenesis of fibrosis diseases. Nevertheless, the contribution of periostin in OSF remains to be uncovered. Read More

View Article and Full-Text PDF

PTEN and α-SMA Expression and Diagnostic Role in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma with Concomitant Oral Submucous Fibrosis.

J Oral Maxillofac Res 2021 Jan-Mar;12(1):e3. Epub 2021 Mar 31.

Department of Oral and Maxillofacial Pathology and Oral Microbiology, SDM College of Dental Sciences and Hospital, DharwadIndia.

Objectives: The diagnostic role and correlation between phosphatase and tensin homologue and alpha-smooth muscle actin in oral submucous fibrosis and oral squamous cell carcinoma with concomitant oral submucous fibrosis was analysed by this case control study. The mechanism by which phosphatase and tensin homologue controls myofibroblast expression was also evaluated.

Material And Methods: Overall, 10 normal mucosa, 30 oral submucous fibrosis (OSF) and 30 oral squamous cell carcinoma (OSCC) with OSF were stained immunohistochemically with phosphatase and tensin homologue (PTEN) and alpha-smooth muscle actin (α-SMA). Read More

View Article and Full-Text PDF

A Novel Buccal Shield to Prevent Cheek Biting in Post-surgical OSMF Patients.

J Maxillofac Oral Surg 2021 Jun 20;20(2):325-327. Epub 2020 Jun 20.

Department of Dentistry, AIIMS, Jodhpur, India.

View Article and Full-Text PDF

The diagnostic and prognostic utility of insulin growth factor of squamous cell carcinoma in oral cavity.

Tzu Chi Med J 2021 Apr-Jun;33(2):160-164. Epub 2020 Aug 25.

Department of Biochemistry, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India.

Objective: The present study was conducted to find the utility of insulin growth factors (IGFs) as diagnostic and prognostic biochemical parameters in patients suffering from squamous cell carcinoma of oral cavity.

Materials And Methods: A total of 360 male and female patients diagnosed with precancerous conditions (PCC) and oral squamous cell carcinoma (OSCC) of Stage I to IV were selected for the present study. Patients were interviewed using a structured questionnaire to ascertain their demographic and medical history. Read More

View Article and Full-Text PDF

Triphala extract negates arecoline-induced senescence in oral mucosal epithelial cells in vitro.

Saudi J Biol Sci 2021 Apr 21;28(4):2223-2228. Epub 2021 Jan 21.

Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, India.

Background: Arecoline found in areca nut causes oral submucous fibrosis. Triphala is an Ayurvedic medicinal preparation used to improve overall physical wellness that has also been shown to improve oral health.

Objectives: To assess the activity of Triphala extract on arecoline-induced senescence in oral mucosal epithelial cells in vitro. Read More

View Article and Full-Text PDF

To ponder beyond hype!!!

Natl J Maxillofac Surg 2020 Jul-Dec;11(2):307-308. Epub 2020 Dec 16.

Department of Oral Medicine and Radiology, Dr. G D Pol Foundation's, YMT Dental College and Hospital, Navi Mumbai, Maharashtra, India.

To date, no treatment strategies for oral submucous fibrosis (OSMF) have been proved to be completely effective, and one of the most accepted medical lines of therapy advised in every stage of OSMF is antioxidants. One of the antioxidant drugs has increasingly earned popularity, which is due to its less expensive market price than other available antioxidants formulations. The presence of copper in its composition questions its ability to be effective in the management of OSMF. Read More

View Article and Full-Text PDF
December 2020

Multi-target pharmacological mechanisms of Salvia miltiorrhiza against oral submucous fibrosis: A network pharmacology approach.

Arch Oral Biol 2021 Jun 19;126:105131. Epub 2021 Apr 19.

Department of Oral Pathology, Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, NMPA Key Laboratory for Dental Materials, Beijing, 100081, People's Republic of China; Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions, Chinese Academy of Medical Sciences (2019RU034), Beijing, 100081, People's Republic of China. Electronic address:

Objectives: The herb Salvia miltiorrhiza is used to treat oral submucous fibrosis (OSF); however, the mechanism underlying its efficacy has not been elucidated. As such, a network pharmacology-based approach was applied to investigate the potential mechanisms of Salvia miltiorrhiza against OSF.

Materials And Methods: Potential targets of Salvia miltiorrhiza were collected by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine, and Swiss Target Prediction. Read More

View Article and Full-Text PDF

Estimation of salivary matrix metalloproteinases- 12 (MMP- 12) levels among patients presenting with oral submucous fibrosis and oral squamous cell carcinoma.

BMC Oral Health 2021 04 23;21(1):205. Epub 2021 Apr 23.

School of Public Health, Dow University of Health Sciences, Karachi, Pakistan.

Background: Oral squamous cell carcinoma is a global threat and accounts for approximately 90% of malignant oral lesions. The emergence of oral carcinoma is linked to precancerous lesions, which act as precursors of the disease. Matrix metalloproteinases appear to play a significant role in the pathogenesis of both precancerous conditions and oral malignancies due to their participation in remodeling of the extracellular matrix. Read More

View Article and Full-Text PDF

Esophageal Cancer, Central Airway Obstruction, and Lots More: A Collaborative Approach to a Challenging Scenario.

Turk Thorac J 2021 Mar 1;22(2):175-178. Epub 2021 Mar 1.

Department of Pulmonary Medicine, All India Institute of Medical Sciences, Jodhpur, India.

Esophageal cancer is the most common cause of extrapulmonary malignant central airway obstruction (MCAO). MCAO is usually managed by a multidisciplinary approach involving tumor debulking, stent placement, and palliative radiotherapy. MCAO is a challenge in itself; here, it becomes even more challenging as it was accompanied by grade 3 oral submucous fibrosis, nasal synechiae, and multiple enlarged cervical nodes causing excessive compression of the trachea along with acute hypercapnic respiratory failure. Read More

View Article and Full-Text PDF

Small Molecule "Silmitasertib" Repurposed as Inhibitor of Transforming Growth Factor Beta 1 for the Development of Therapeutics for Oral Submucous Fibrosis.

Authors:
Nezar Boreak

Biomed Res Int 2021 1;2021:6631848. Epub 2021 Apr 1.

Department of Restorative Dental Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

Oral submucous fibrosis (OSMF) is considered a premalignant condition characterized by aggressive fibrosis of the submucosal tissues of the oral cavity reflecting its malignant transformation potential. Activation of transforming growth factor beta (TGF-) signaling has been reported to lead increased collagen production and fibrosis. Recently, significant upregulation of TGF-1 has been reported in OSMF as compared to normal tissues. Read More

View Article and Full-Text PDF

Efficacy of collagen-silicone bilayer membrane in the management of oral submucous fibrosis: a prospective case series.

Oral Maxillofac Surg 2021 Apr 17. Epub 2021 Apr 17.

Department of Oral and Maxillofacial Surgery, Bapuji Dental College and Hospital, Davangere, Karnataka, India.

Background And Objective: Oral submucous fibrosis is a scourge of Southeastern Asia since a long time resulting in significant health and social problems. Mainstay of the treatment is concentrated on attempts to improve mouth opening and relieve the symptoms by medicinal or surgical means. In moderate to severe cases, release of fibrous bands is advocated followed by placement of graft. Read More

View Article and Full-Text PDF

From Simple Mouth Cavities to Complex Oral Mucosal Disorders-Curcuminoids as a Promising Therapeutic Approach.

ACS Pharmacol Transl Sci 2021 Apr 17;4(2):647-665. Epub 2021 Mar 17.

Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, Assam 781039, India.

Oral diseases are among the most common encountered health issues worldwide, which are usually associated with anomalies of the oral cavity, jaws, and salivary glands. Despite the availability of numerous treatment modalities for oral disorders, a limited clinical response has been observed because of the inefficacy of the drugs and countless adverse side effects. Therefore, the development of safe, efficacious, and wide-spectrum therapeutics is imperative in the battle against oral diseases. Read More

View Article and Full-Text PDF

Oral submucous fibrosis and heterogeneity in outcome measures: a critical viewpoint.

Future Oncol 2021 Jun 16;17(17):2123-2126. Epub 2021 Apr 16.

Department of Oral Pathology & Microbiology, Saveetha Dental College & Hospitals, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai, 600077, India.

View Article and Full-Text PDF

[Efficacy of curcumin in the treatment of oral submucous fibrosis: a Meta-analysis].

Hua Xi Kou Qiang Yi Xue Za Zhi 2021 Apr;39(2):195-202

Dept. of Mathematics, Hong Kong Baptist University, Hongkong 999077, China.

Objectives: This study was performed to review the efficacy of curcumin in the treatment of oral submucous fibrosis systematically.

Methods: We searched seven databases, including Web of Science, PubMed, EBSCO, The Cochrane Library, CNKI, WanFang Data, and VIP, to obtain randomized controlled trials related to the treatment of oral submucous fibrosis by curcumin. Each database was searched from inception to 30 June 2019. Read More

View Article and Full-Text PDF

Fibrotic expression profile analysis reveals repurposed drugs with potential anti-fibrotic mode of action.

PLoS One 2021 7;16(4):e0249687. Epub 2021 Apr 7.

Department of Bioinformatics, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.

Fibrotic diseases cover a spectrum of systemic and organ-specific maladies that affect a large portion of the population, currently without cure. The shared characteristic these diseases feature is their uncontrollable fibrogenesis deemed responsible for the accumulated damage in the susceptible tissues. Idiopathic Pulmonary Fibrosis, an interstitial lung disease, is one of the most common and studied fibrotic diseases and still remains an active research target. Read More

View Article and Full-Text PDF

Research Achievements of Oral Submucous Fibrosis: Progress and Prospect.

Biomed Res Int 2021 18;2021:6631856. Epub 2021 Mar 18.

Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Oral submucous fibrosis (OSMF) is a kind of chronic, insidious disease, and it is categorized into potentially malignant disorders (PMD), which poses a global and regional problem to public health. It is considered to be a multifactorial disease, such as due to areca nut chewing, trace element disorders, and genetic susceptibility. However, there is still no unanimous conclusion on its pathogenesis, diagnosis, and treatment strategies. Read More

View Article and Full-Text PDF

Oral submucous fibrosis in children: an alarming condition and challenges in management.

BMJ Case Rep 2021 Mar 23;14(3). Epub 2021 Mar 23.

OMFS, Sri Aurobindo College of Dentistry, Indore, Madhya Pradesh, India.

Oral submucous fibrosis (OSF) is a well-documented potentially malignant condition. It affects most commonly the adult patients of India and Indian subcontinent, only few cases affecting children have been reported in the literature. This paper presents three cases of OSF below the age of 12 years and reviews the aetiology, clinical presentation, treatment modalities in children with improved follow-up results. Read More

View Article and Full-Text PDF

Effect of botulinum toxin-A on pain and mouth opening following surgical intervention in oral submucous fibrosis - A controlled clinical trial.

J Craniomaxillofac Surg 2021 Feb 5. Epub 2021 Feb 5.

Department of Oral and Maxillofacial Surgery, All India Institute of Medical Sciences, New Delhi, 110023, India. Electronic address:

The purpose of this trial was to study the effect on pain and mouth opening of intramuscular injection of botulinum toxin-A into masticatory muscles following surgical intervention in oral submucous fibrosis (OSMF) cases. Injections of either botulinum toxin A (BTX-A) (study group) or normal saline (control group) were given 2 weeks prior to surgical intervention in OSMF patients, into the bilateral masseter and temporalis muscles. All patients were evaluated for pain and ease of active physiotherapy at 1 week and 1, 3, and 6 months after surgery using a numerical rating scale and appropriate questionnaires, with comparisons made between the study and control group patients. Read More

View Article and Full-Text PDF
February 2021

Skewed Th17/Treg balance during progression and malignant transformation of oral submucous fibrosis.

Oral Dis 2021 Mar 22. Epub 2021 Mar 22.

Hunan Key Laboratory of Oral Health Research & Hunan 3D, Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, 410008, Hunan, China.

Objectives: The aim of our study was to determine the impact of Th17/Treg imbalance on the progression and malignant transformation of oral submucosal fibrosis (OSF).

Materials And Methods: To assess Th17 and Treg expression, overall 52 peripheral blood samples from OSF, oral squamous cell carcinoma (OSCC) patients and healthy donors were analyzed by flow cytometry. 30 normal oral mucosa 72 OSF and 90 OSCC samples were analyzed by immunohistochemistry. Read More

View Article and Full-Text PDF

Targeting lncRNA H19/miR-29b/COL1A1 Axis Impedes Myofibroblast Activities of Precancerous Oral Submucous Fibrosis.

Int J Mol Sci 2021 Feb 23;22(4). Epub 2021 Feb 23.

Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.

Oral submucous fibrosis (OSF) is known as a potentially malignant disorder, which may result from chemical irritation due to areca nuts (such as arecoline). Emerging evidence suggests that fibrogenesis and carcinogenesis are regulated by the interaction of long noncoding RNAs (lncRNAs) and microRNAs. Among these regulators, profibrotic lncRNA has been found to be overexpressed in several fibrosis diseases. Read More

View Article and Full-Text PDF
February 2021