1,291 results match your criteria Oral Submucous Fibrosis


Efficacy of curcumin for management of oral submucous fibrosis: a systematic review of randomized clinical trials.

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Jan 16. Epub 2019 Jan 16.

Department of Oral Medicine and Diagnostic Science, Al Farabi Colleges, Riyadh, Kingdom of Saudi Arabia. Electronic address:

Objectives: Oral submucous fibrosis (OSF) is a chronic debilitating disease that has a high risk of malignant transformation. Management of OSF is quite challenging, with no definitive cure being available. This systematic review assessed the available evidence for using curcumin for pain alleviation and clinical improvement in patients with OSF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22124403193001
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http://dx.doi.org/10.1016/j.oooo.2019.01.010DOI Listing
January 2019
1 Read

Oral submucous fibrosis: A clinicopathological study of 674 cases in China.

J Oral Pathol Med 2019 Feb 4. Epub 2019 Feb 4.

Department of oral pathology, Xiangya Stomatological Hospital, Central South University, Changsha, Hunan, China.

Background: Oral submucous fibrosis (OSF) has been reported frequently in India and other countries in South Asia. There are few reports on the clinicopathological features of OSF in China, where OSF is an epidemic. This study analyses the clinicopathological features of OSF in Hunan Province, China. Read More

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http://dx.doi.org/10.1111/jop.12836DOI Listing
February 2019

Stress activated p38 MAPK regulates cell cycle via AP-1 factors in areca extract exposed human lung epithelial cells.

Cytotechnology 2019 Feb 2. Epub 2019 Feb 2.

Department of Microbiology and Biotechnology, Bangalore University, Jnana Bharathi, Bengaluru, Karnataka, 560 056, India.

Areca nut chewing habits are associated with several oral manifestations like leukoplakia, submucous fibrosis and oral squamous cell carcinoma. Although numerous evidence on areca toxicity is known but the mechanistic pathway of disease causation is to be studied. Aqueous areca nut extract treated A549 cells showed reduced cell viability by 48 h with IC value of 0. Read More

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http://dx.doi.org/10.1007/s10616-019-00297-3DOI Listing
February 2019
1 Read

Differential expression of salivary S100A7 in oral submucous fibrosis.

Saudi Dent J 2019 Jan 24;31(1):39-44. Epub 2018 Sep 24.

Department of Periodontology, Faculty of Dentistry, Ziauddin University, 75600 Karachi, Pakistan.

Aim: To investigate the expression of salivary S100A7 levels among patients with oral submucous fibrosis (OSF) and healthy controls.

Method: A total number of 60 participants were included in the study (30 OSF cases and 30 healthy controls). Demographic data was collected using a structured baseline questionnaire. Read More

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http://dx.doi.org/10.1016/j.sdentj.2018.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349954PMC
January 2019

Is Periodontitis Independently Associated with Potentially Malignant Disorders of the Oral Cavity?

Asian Pac J Cancer Prev 2019 Jan 25;20(10):283-287. Epub 2019 Jan 25.

Department of Public Health Dentistry, Sharavathi Dental College and Hospital, Shimoga, India. Email:

Objective: To examine if periodontitis is independently associated with oral potentially malignant disorders (OPMD) in a rural Indian adult population aged 35-54 years. Methods: A population-based cross-sectional study was conducted in rural India from 2011 to 2012. Multistage stratified cluster random sampling was followed to recruit 1401 participants aged 35-54 years. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.283DOI Listing
January 2019

Impact of socioeconomic inequalities on quality of life in oral submucous fibrosis patients.

Future Oncol 2019 Jan 23. Epub 2019 Jan 23.

Department of Oral Pathology & Microbiology, Dr DY Patil Dental College & Hospital, Dr DY Patil Vidyapeeth, Pune, Maharashtra, India.

Aim: The purpose of this study was to analyze the impact of socioeconomic characteristics on oral health-related quality of life (OHRQoL) in patients with oral submucous fibrosis (OSF).

Methods:  A total of 300 OSF patients' quality of life (QoL) data were obtained using OHRQoL-OSF and global self ratings of oral health and overall wellbeing. The socioeconomic status (SES) of participants was analyzed by using modified Kuppuswamy scale. Read More

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http://dx.doi.org/10.2217/fon-2018-0645DOI Listing
January 2019
2.477 Impact Factor

Insight on the relationship of ABO blood grouping associated with oral premalignant lesions, conditions and inherited oral cancer syndromes.

J Exp Ther Oncol 2019 Jan;13(1):59-63

Resident, MOH, Department of Oral and Maxillofacial Surgery, King Khalid Hospital, Najran, Kingdom of Saudi Arabia.

Background: Risk factors such as chronic use of tobacco, smoking and alcohol consumption of individual's lifestyle may possibly influence the significant role in the etiopathogenesis of precancerous lesions (PL) and Conditions (PC) and lead to oral cancer. Previous studies have revealed that genetic factors have contributed to a remarkable extent in the development of this chronic disease. Limited studies have confirmed that ABO blood groups remain reportedly possible genetic factor to the specific disease such as oral malignant. Read More

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January 2019

Variants in FAT1 and COL9A1 genes in male population with or without substance use to assess the risk factors for oral malignancy.

PLoS One 2019 18;14(1):e0210901. Epub 2019 Jan 18.

Environment-Omics-Disease Research Center, China Medical University Hospital, Taichung, Taiwan.

A number of genetic variants were suggested to be associated with oral malignancy, few variants can be replicated. The aim of this study was to identify significant variants that enhanced personal risk prediction for oral malignancy. A total of 360 patients diagnosed with oral squamous cell carcinoma, 486 controls and 17 newly diagnosed patients with OPMD including leukoplakia or oral submucous fibrosis were recruited. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210901PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338366PMC
January 2019
7 Reads

A novel clinical protocol for therapeutic intervention in oral submucous fibrosis: An evidence based approach.

J Oral Maxillofac Pathol 2018 Sep-Dec;22(3):382-391

Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.

Oral submucous fibrosis (OSMF) is a chronic, progressive, debilitating, scarring and crippling disorder of the oral cavity. It is a potentially malignant oral disease which predominantly affects people of South and Southeast Asia, especially Indian subcontinent, where chewing of areca nut and its commercial preparation is rampant. However, due to increase in immigration of people from the Indian subcontinent, the health professionals in many developed countries do come across this disease very often. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_223_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306594PMC
January 2019
8 Reads

Estimation of serum hepcidin in oral submucous fibrosis before and after supplementation with oral iron: A randomized control clinical trial.

J Oral Maxillofac Pathol 2018 Sep-Dec;22(3):303-306

Department of Oral Medicine and Radiology, Sri Rajiv Gandhi College of Dental Sciences and Hospital, Bengaluru, Karnataka, India.

Background: Iron-deficiency anemia is synonymous with oral submucous fibrosis (OSMF). The cause for the same has not been ascertained yet. OSMF by way of anemia of chronic disease could be a probable cause of iron deficiency. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_112_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306602PMC
January 2019
3 Reads

Ultrasonographic evaluation of submucosal thickness in oral submucous fibrosis patients: a cross-sectional study.

Pol J Radiol 2018 14;83:e280-e288. Epub 2018 Jun 14.

V.S.P.M. Dental College and Research Center, Nagpur, India.

Purpose: To evaluate the role of ultrasonography in oral submucous fibrosis (OSMF) patients.

Material And Methods: A total of 150 subjects were divided equally into six groups (Group I: 25 healthy subjects; Group II: 25 healthy subjects with habit; Group III: 25 OSMF stage I; Group IV: 25 OSMF stage II; Group V: 25 OSMF stage III; and Group VI: 25 stage OSMF IVA). The grading of OSMF were done according the clinical classification given by Khanna and Andrade (2005). Read More

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http://dx.doi.org/10.5114/pjr.2018.76795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323594PMC

A potential new oral mapping (OM) method in the clinical evaluation and documentation of oral submucous fibrosis-A prospective clinical crossover study.

J Oral Pathol Med 2019 Jan 3. Epub 2019 Jan 3.

Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK.

Background: Despite much research, there is a lack of a definite protocol or method for documenting oral submucous fibrosis (OSMF) site presentation. In this study, we propose a new potential oral mapping (OM) method and evaluated its use in recording OSMF-affected mucosal sites.

Methods: Fifty OSMF patients were evaluated by 15 primary care dental practitioners using both, a conventional subjective recording method and a new OM method, to document the degree of involvement of affected oral mucosa with a crossover study design. Read More

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http://doi.wiley.com/10.1111/jop.12821
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http://dx.doi.org/10.1111/jop.12821DOI Listing
January 2019
10 Reads

Prospective cross-sectional study assessing prevalence and factors affecting trismus after multimodal treatment for oral cancers.

Head Neck 2019 Feb 12;41(2):286-290. Epub 2018 Dec 12.

Department of Head and Neck Surgery, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Background: Trismus is a common complication following treatment for oral cancers. However, its incidence in site-specific cancers is not adequately studied. The purpose of this study was to assess the prevalence and risk factors associated with trismus in treated patients with oral cancer. Read More

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http://dx.doi.org/10.1002/hed.25464DOI Listing
February 2019
1 Read

Evaluation of mast cells in oral premalignant and malignant lesions: A histochemical study.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):184-190

Department of Oral Medicine and Radiology, Pacific Dental College, Udaipur, Rajasthan, India.

Introduction: Oral leukoplakia, oral submucous fibrosis, and oral lichen planus are the precancerous or potentially malignant lesions and conditions whereas oral squamous cell carcinoma (OSCC) is a cancerous or malignant lesion of the oral cavity. They have characteristic clinical and histopathological features. These diseases not only originate from epithelium but also associated with chronic inflammation juxta-epithellialy. Read More

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http://www.njms.in/text.asp?2018/9/2/184/245349
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http://dx.doi.org/10.4103/njms.NJMS_49_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251297PMC
December 2018
19 Reads

Oral health-related quality of life among male subjects with oral submucous fibrosis in a tertiary care hospital.

Indian J Public Health 2018 Oct-Dec;62(4):271-276

Senior Resident, Oral Health Sciences Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, Union Territory, India.

Background: Oral submucous fibrosis is very common in Asia. It has many deleterious effects on individual's oral functions. Thus, there is a need to assess the effect of oral submucous fibrosis on quality of life. Read More

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http://www.ijph.in/text.asp?2018/62/4/271/247220
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http://dx.doi.org/10.4103/ijph.IJPH_179_17DOI Listing
December 2018
1 Read

Oral submucous fibrosis - Is it time to modify the definition?

Oral Oncol 2018 Dec 24;87:203. Epub 2018 Oct 24.

Department of Oral Medicine and Radiology, The Oxford Dental College, Bangalore, India.

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http://dx.doi.org/10.1016/j.oraloncology.2018.10.025DOI Listing
December 2018

Malignant transformation to oral cancer by subtype of oral potentially malignant disorder: A prospective cohort study of Taiwanese nationwide oral cancer screening program.

Oral Oncol 2018 Dec 24;87:58-63. Epub 2018 Oct 24.

School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Objectives: To elucidate the risk of malignant transformation to invasive oral cancer by subtypes of oral potentially malignant disorders (OPMD) and to examine the independent effects of risk factors, particularly alcohol drinking, by subtype based on a nationwide oral cancer screening program targeting at general population with habits of smoking and/or betel quids chewing.

Materials And Methods: The total of 8501 subjects diagnosed as different subtypes of OPMDs from the Taiwanese screening program between 2004 and 2009 were followed up over time to ascertain the occurrence of invasive oral cancer. The hazard ratios of malignant transformation were estimated by using Cox proportional hazards regression model. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375183038
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http://dx.doi.org/10.1016/j.oraloncology.2018.10.021DOI Listing
December 2018
7 Reads

Immunolocalization of c-Jun in normal mucosa, oral submucous fibrosis, epithelial dysplasia, and oral squamous cell carcinoma: A comparative study.

J Cancer Res Ther 2018 Oct-Dec;14(6):1180-1183

Department of Oral and Maxillofacial Pathology, SDM College of Dental Sciences and Hospital, Dharwad, Karnataka, India.

Background And Objective: c-Jun an activator protein-1 transcription factor component is activated by a variety of extracellular stimuli. Overexpression of c-Jun has been implicated in the pathogenesis of several types of cancer including oral cancer. The aim of this study was to correlate the expression of c-Jun in the normal buccal mucosa (NM), oral submucous fibrosis (OSMF), severe epithelial dysplasia (ED), and well-differentiated squamous cell carcinoma (WDSCC). Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_324_16DOI Listing
November 2018

Pathogenesis investigation of miR-199-5p in oral submucous fibrosis based on bioinformatics analysis.

Oral Dis 2019 Mar 19;25(2):456-465. Epub 2018 Dec 19.

Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, China.

Objectives: Fibrosis diseases are one of the leading causes of suffering and death. However, no systematic investigation has been carried out on fibrosis-related genes.

Materials And Methods: By querying PubMed using keywords "fibrosis" and "gene" or "protein," we identified fibrosis-related genes in the last decade. Read More

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http://dx.doi.org/10.1111/odi.13008DOI Listing
March 2019
1 Read

Estimation of serum beta-carotene level in patients suffering from oral submucous fibrosis.

J Exp Ther Oncol 2018 Nov;12(4):267-271

Department of Oral Medicine & Radiology, Government Dental College and Hospital, Aurangabad, Maharashtra, India.

Introduction: Oral submucous fibrosis (OSMF), an insidious disease, has not been widely studied with respect to levels of serum beta-carotene (b-carotene). Hence present study aimed to estimate level of serum beta carotene in patients with OSMF.

Material And Methods: 40 subjects (study subjects) with different grades of OSMF and 40 apparently healthy subjects without OSMF (control subjects with age and sex matched as that of study subjects) were screened for serum b-carotene levels employing Sobel and Snow's method. Read More

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November 2018
9 Reads

LncRNA LINC00974 activates TGF-β/Smad signaling to promote oral fibrogenesis.

J Oral Pathol Med 2019 Feb 9;48(2):151-158. Epub 2018 Dec 9.

School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.

Background: Oral submucous fibrosis (OSF) is a progressive scarring disease and has been considered as a premalignant condition of the oral cavity. However, the detailed molecular mechanisms underlying the pathogenesis of OSF are still unclear.

Method: Here, we examined the expression of a novel long non-coding RNA LINC00974 in OSF and investigated its function role in myofibroblast transdifferentiation. Read More

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http://doi.wiley.com/10.1111/jop.12805
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http://dx.doi.org/10.1111/jop.12805DOI Listing
February 2019
26 Reads
1.870 Impact Factor

Evaluation of the Prevalence of Oral Mucosal Lesions in a Population of Eastern Coast of South India.

J Int Soc Prev Community Dent 2018 Sep-Oct;8(5):396-401. Epub 2018 Oct 8.

Department of Public Health Dentistry, Sibar Institute of Dental Sciences and Research, Guntur, Andhra Pradesh, India.

Objective/aim: The aim of this study is to measure the association between oral mucosal lesions (OMLs) and habit of tobacco and alcohol in the population of Guntur city, Andhra Pradesh, South India.

Material And Method: A cross-sectional study was conducted on 300 participants in Guntur city with the habit of tobacco and alcohol consumption in various forms who were selected by stratified cluster random sampling technique. Guntur city was divided into four zones, that is, North, East, South, and West; and two administrative wards were randomly selected from each zone as clusters. Read More

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http://www.jispcd.org/text.asp?2018/8/5/396/242866
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http://dx.doi.org/10.4103/jispcd.JISPCD_207_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187880PMC
October 2018
3 Reads

An Evaluation of Clinical and Histopathological Aspects of Patients with Oral Submucous Fibrosis in the Background of Oral Squamous Cell Carcinoma.

Biomed Res Int 2018 9;2018:4154165. Epub 2018 Oct 9.

Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.

Background: The behavior and prognosis of oral squamous cell carcinoma (OSCC) is presumably different in patients with oral submucous fibrosis (OSF). The objective of this study was to assess the effects of demographic features, habits, and histopathological features in the transformation of OSF to OSCC.

Methods: Data were extracted from the archives and histopathological evaluation and presence of nodal metastasis were recorded. Read More

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https://www.hindawi.com/journals/bmri/2018/4154165/
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http://dx.doi.org/10.1155/2018/4154165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198553PMC
February 2019
15 Reads

Extended nasolabial flap in oral submucous fibrosis - our modification.

Authors:
S Sidana

J Stomatol Oral Maxillofac Surg 2019 Feb 27;120(1):71-73. Epub 2018 Oct 27.

Department of Oral and Maxillofacial Surgery MGM Dental College and Hospital, Kamothe, Navi Mumbai, India. Electronic address:

Nasolabial Flaps are the most popular and commonly used flap in reconstructing mucosal defect left by fibrous band excision in developing countries like India where free flap expertise is not easily available and affordable by poor patients. Extended nasolabial flaps have been used in oral sub mucous fibrosis to cover mucosal defect. Normally these flaps are not wide enough to cover the mucosal defect left by fibrous band excision. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24687855183021
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http://dx.doi.org/10.1016/j.jormas.2018.10.003DOI Listing
February 2019
5 Reads

Delineating metabolic dysfunction in cellular metabolism of oral submucous fibrosis using H nuclear magnetic resonance spectroscopy.

Arch Oral Biol 2019 Jan 21;97:102-108. Epub 2018 Oct 21.

School of Medical Science and Technology, IIT Kharagpur, India.

Objective: To delineate the metabolism involved in oral submucous fibrosis progression towards carcinogenesis by H nuclear magnetic resonance spectroscopy.

Methods: The proposed study was designed using H-NMR by comparing the metabolites in the serum sample of oral submucous fibrosis (n = 20) compared to the normal group (n = 20) using H nuclear magnetic resonance spectroscopy. Various statistical analysis like multivariate statistical analysis, Principle component analysis, Partial least squares Discriminant Analysis, Hierarchical cluster analysis was applied to analyze potential serum metabolites. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2018.10.016DOI Listing
January 2019
2 Reads

Collagen Membrane Over Buccal Fat Pad Versus Buccal Fat Pad in Management of Oral Submucous Fibrosis: A Comparative Prospective Study.

J Maxillofac Oral Surg 2018 Dec 11;17(4):482-487. Epub 2017 Sep 11.

Department of Oral and Maxillofacial Surgery, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.

Objective: The objective of this study was to assess the effectiveness of collagen membrane as biological dressing over buccal fat pad (BFP) during crucial postoperative healing phase in the surgical management of oral submucous fibrosis (OSMF).

Study Design: The study comprised of 40 patients of OSMF of group IVa (Khanna and Andrade). Patients were randomly divided in two groups (20 patients in each group). Read More

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http://link.springer.com/10.1007/s12663-017-1041-8
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http://dx.doi.org/10.1007/s12663-017-1041-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181840PMC
December 2018
9 Reads

Aloe vera in treatment of oral submucous fibrosis: A systematic review and meta-analysis.

J Oral Pathol Med 2019 Feb 7;48(2):99-107. Epub 2018 Nov 7.

Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

The management of oral submucous fibrosis (OSF) is quite challenging, and as yet, no effective therapy is available for its management. The present systematic review and meta-analysis sought to assess the effectiveness of aloe vera in alleviating pain and clinical signs of OSF. A comprehensive search in PubMed/Medline, Scopus, and Web of Science databases was conducted to identify the relevant randomized clinical trials. Read More

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http://dx.doi.org/10.1111/jop.12789DOI Listing
February 2019
1.870 Impact Factor

A New Intraoral Appliance for Trismus in Oral Submucous Fibrosis.

Case Rep Dent 2018 9;2018:1039391. Epub 2018 Sep 9.

Department of Orthodontics and Dentofacial Orthopedics, Panineeya Institute of Dental Sciences, Hyderabad, India.

Trismus is the most common sequelae of various pathological processes leading to compromised nutritional state in addition to physical and psychological disabilities. Therapeutic interventions are available to relieve trismus, which range from oral usage of pharmacological agents to intralesional steroid therapy. Intraoral appliance therapy can be employed as an alternative or adjuvant treatment for radiotherapy-induced fibrosis and autoimmune disorders such as scleroderma, psychogenic trismus, and oral submucous fibrosis, decreasing the adverse effects associated with other pharmacological interventions. Read More

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http://dx.doi.org/10.1155/2018/1039391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151238PMC
September 2018
14 Reads

Oral health consequences of smokeless tobacco use.

Indian J Med Res 2018 Jul;148(1):35-40

WHO Collaborating Centre for Oral Cancer; King's College London, London, UK.

Smokeless tobacco (SLT) use has many oral effects including oral cancer, leukoplakia and erythroplakia, oral submucous fibrosis (if mixed with areca nut), loss of periodontal support (recession) and staining of teeth and composite restorations. This review was aimed to provide information to identify oral lesions that occur due to the use of smokeless tobacco so that effective interventions can be undertaken to reduce morbidity and mortality from the use of SLT. Read More

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http://www.ijmr.org.in/text.asp?2018/148/1/35/242218
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http://dx.doi.org/10.4103/ijmr.IJMR_1793_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172921PMC
July 2018
7 Reads

Angiotensin (1-7) inhibits arecoline-induced migration and collagen synthesis in human oral myofibroblasts via inhibiting NLRP3 inflammasome activation.

J Cell Physiol 2019 Apr 24;234(4):4668-4680. Epub 2018 Sep 24.

Department of Emergency, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Arecoline induces oral submucous fibrosis (OSF) via promoting the reactive oxygen species (ROS). Angiotensin (1-7) (Ang-(1-7)) protects against fibrosis by counteracting angiotensin II (Ang-II) via the Mas receptor. However, the effects of Ang-(1-7) on OSF remain unknown. Read More

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http://dx.doi.org/10.1002/jcp.27267DOI Listing
April 2019
4 Reads
3.840 Impact Factor

Surgical management of oral submucous fibrosis using buccal fat pad: a retrospective study of 30 cases.

Oral Maxillofac Surg 2018 Dec 21;22(4):403-408. Epub 2018 Sep 21.

303 Field Hospital, c/o 56 APO, New Delhi, India.

The aim of our study was to evaluate the effectiveness of buccal fat pad (BFP) in the management of oral submucous fibrosis (OSMF). Retrospective records of 30 patients of OSMF treated with BFP with atleast a year of follow-up were analyzed. Patients were divided into groups based on the stages of OSMF. Read More

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http://dx.doi.org/10.1007/s10006-018-0721-yDOI Listing
December 2018
17 Reads

Slug mediates myofibroblastic differentiation to promote fibrogenesis in buccal mucosa.

J Cell Physiol 2019 May 19;234(5):6721-6730. Epub 2018 Sep 19.

School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.

Epithelial-mesenchymal transition (EMT) has been implicated in fibrogenesis and carcinogenesis; however, the exact role of EMT-inducer Slug in the progression of precancerous oral submucous fibrosis (OSF) has not been investigated. In the current study, we showed that the expression of Slug was upregulated in OSF tissues and associated with various myofibroblast markers. After silence of Slug in fibrotic buccal mucosal fibroblasts (fBMFs), the elevated myofibroblast activities and fibrosis markers were all downregulated. Read More

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http://dx.doi.org/10.1002/jcp.27418DOI Listing
May 2019
3 Reads
3.840 Impact Factor

Comparison of microvessel density using CD34 and CD105 in oral submucous fibrosis and its correlation with clinicopathological features: An immunohistochemical study.

J Cancer Res Ther 2018 Jul-Sep;14(5):983-988

Department of Oral Pathology and Microbiology, Maratha Mandal's NG Halgekar Institute of Dental Sciences and Research Centre, Belgaum, Karnataka, India.

Objectives: To compare immunohistochemical expression of CD34 and CD105 in oral submucous fibrosis (OSF) and normal oral mucosa (NOM) and correlate with clinicopathological features of OSF.

Materials And Methods: Total of thirty clinically diagnosed and histologically confirmed cases of OSF and 15 NOM were included in the study. Tissues sections were immunostained using CD34 and CD105 antibodies. Read More

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http://www.cancerjournal.net/text.asp?2018/14/5/983/181186
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http://dx.doi.org/10.4103/0973-1482.181186DOI Listing
November 2018
3 Reads

Polarized microscope assisted study of collagen fibres in Oral Submucous Fibrosis and their clinicopathologic correlation: An in-vitro study.

J Oral Biol Craniofac Res 2018 Sep-Dec;8(3):206-211. Epub 2017 Jul 14.

Department of Oral and Maxillofacial Surgery, ITS-CDSR, Muradnagar, Ghaziabad, India.

Background: The present study was aimed to evaluate and analyze orientation and birefringence pattern of collagen fibers histopathologically in different grades of OSMF using the special stain (Picrosirius red) under polarizing microscope and relate these factors with the severity of OSMF.

Materials And Method: 45 confirmed cases of OSMF were taken from the archives. The selection of clinical cases was done according to classification by J. Read More

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http://dx.doi.org/10.1016/j.jobcr.2017.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107934PMC
July 2017
6 Reads

Nasolabial and extended nasolabial flaps for reconstruction in oral submucous fibrosis.

J Korean Assoc Oral Maxillofac Surg 2018 Aug 29;44(4):191-197. Epub 2018 Aug 29.

Specialist Oral and Maxillofacial Surgeon, Department of Dentistry, Cleft Hospital Gujrat Pakistan, Gujrat, Pakistan.

Objectives: The objective of the study was to evaluate the results of nasolabial/extended nasolabial flaps as a modality for treatment of oral submucous fibrosis.

Materials And Methods: Eleven patients of Stage III or IVa maximum interincisal opening were selected to be operated. Nasolabial/extended nasolabial flaps were done for both the sides. Read More

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http://dx.doi.org/10.5125/jkaoms.2018.44.4.191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117461PMC
August 2018
2 Reads

Role of cell proliferation and vascularity in malignant transformation of potentially malignant disorders.

J Oral Maxillofac Pathol 2018 May-Aug;22(2):281

Department of Oral Pathology, Mamata Dental College, Khammam, Telangana, India.

Background: Significant increase in cell proliferation and vascularity occurs during the transition from normal oral mucosa through differing degrees of dysplasia to oral squamous cell carcinoma (OSCC).

Aims: To evaluate the cell proliferation and vascularity in potentially malignant disorders and OSCC.

Settings And Design: Proliferating cell nuclear antigen (PCNA), vascular endothelial growth factor (VEGF) and CD34 were quantified immunohistochemically (IHC) using anti-PCNA, anti-VEGF and anti-CD34 antibody. Read More

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http://www.jomfp.in/text.asp?2018/22/2/281/238279
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http://dx.doi.org/10.4103/jomfp.JOMFP_182_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097360PMC
August 2018
14 Reads

New Directions for Oral Submucous Fibrosis Research: Whole Evaluation for Holistic Rehabilitation!

J Contemp Dent Pract 2018 Aug 1;19(8):901-903. Epub 2018 Aug 1.

Division of Oral Pathology, Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University Jazan, Kingdom of Saudi Arabia.

Oral submucous fibrosis (OSF) is an oral potentially malignant disorder (OPMD) associated with prolonged betel-quid (BQ) use. It affects both physiological and psychological dimensions, leading to a significant morbidity. Some challenges in OSF research include: Assessment and correction of: (i) Quality of life, (ii) burning sensation, and (iii) nutritional deficiency. Read More

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August 2018
3 Reads

Quality of life and oral potentially malignant disorders: Critical appraisal and prospects.

World J Clin Oncol 2018 Aug;9(4):56-59

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia.

Quality of life (QoL) is a vital and often required health outcome measure that is relevant to patient care. A healthy oral cavity enables person to perform daily activities without any limitations. However, any disturbance may result in impaired QoL. Read More

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http://dx.doi.org/10.5306/wjco.v9.i4.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107473PMC
August 2018
18 Reads

Association between kharra chewing and periodontal health status in oral submucous fibrosis patients of Central India, Nagpur.

J Indian Soc Periodontol 2018 Jul-Aug;22(4):345-347

Department of Ear, Nose and Throat, NKP Salve Institute of Medical Sciences, Nagpur, Maharashtra, India.

Purpose: Kharra is a mixture of areca nut and tobacco. Arecoline, an areca nut extract, disrupts the harmony of the periodontal cells and thus leads to destruction of the periodontium. Oral submucous fibrosis (OSMF) is a premalignant condition that arises due to the consumption of kharra. Read More

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http://dx.doi.org/10.4103/jisp.jisp_130_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077969PMC
August 2018
2 Reads

[Clinical analysis for oral mucosal disease in 21 972 cases].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jul;43(7):779-783

Department of Oral Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To analyze the incidence and distribution of oral mucosal diseases in Hunan Province and provide reference for prevention and treatment.
 Methods: The clinical data for all patients, who were treated in Xiangya Hospital of Central South University from April 2013 to March 2017, were collected. After screening, weighing and classifying, sex and age distribution for the disease was analyzed. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.07.013DOI Listing
July 2018
1 Read

Estimation of Salivary and Serum Lactate Dehydrogenase in Oral Submucous Fibrosis.

J Int Soc Prev Community Dent 2018 Jul-Aug;8(4):289-295. Epub 2018 Jul 18.

Department of Oral Medicine and Radiology, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha, India.

Aim And Objectives: The objective of the present study was to estimate the serum and salivary lactate dehydrogenase (LDH) levels in patients with oral submucous fibrosis (OSMF) and to study the association between serum and salivary LDH levels and mouth opening, frequency of habit, and duration of habit in patients with OSMF.

Materials And Methods: Participants were divided into two groups: Group I - case group diagnosed with OSMF and Group II - the control group. Unstimulated whole saliva was collected from all the participants. Read More

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http://dx.doi.org/10.4103/jispcd.JISPCD_214_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071348PMC
July 2018
11 Reads

Correlation of Betel Quid with Oral Cancer from 1998 to 2017: A Study Based on Bibliometric Analysis.

Chin Med J (Engl) 2018 Aug;131(16):1975-1982

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

Background: Betel quid chewing has been a major risk factor for oral cancer (OC) in southern China. This study aimed to analyze the scientific publications on the relationship between betel quid chewing and OC and construct a model to quantitatively and qualitatively evaluate pertinent publications from 1998 to 2017.

Methods: The publications from 1998 to 2017 were retrieved from the Web of Science Core Collection database. Read More

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http://dx.doi.org/10.4103/0366-6999.238140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085852PMC
August 2018
1 Read

Correlation of Clinical and Histopathological Grades in Oral Submucous Fibrosis Patients with Oxidative Stress Markers in Saliva.

Indian J Clin Biochem 2018 Jul 13;33(3):348-355. Epub 2017 Sep 13.

3Department of Oral Pathology, Faculty of Dental Sciences, Sri Ramachandra University, Porur, Chennai, 600 116 India.

This study aimed to correlate the oxidative stress marker levels in saliva with the clinical stage based on mouth opening, fibrotic bands and histopathological grades of oral submucous fibrosis (OSF) patients. The study included patients clinically diagnosed with OSF (n = 63) and equal number of age and gender matched controls. Patients with OSF were defined by mouth opening stage, fibrotic bands and histopathological grades. Read More

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http://dx.doi.org/10.1007/s12291-017-0689-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052729PMC
July 2018
1 Read

Comparison of therapeutic response of lycopene and curcumin in oral submucous fibrosis: A randomized controlled trial.

Oral Dis 2018 Jul 30. Epub 2018 Jul 30.

Department of Oral Medicine & Radiology, Maulana Azad Institute of Dental Sciences, New Delhi, India.

Objectives: To evaluate and compare the therapeutic response of lycopene and curcumin with placebo in patients suffering from oral submucous fibrosis (OSMF) and to correlate the habit variables of smoked and smokeless tobacco products in OSMF.

Methods: A randomized placebo-controlled parallel clinical study was conducted on ninety OSMF patients, who were divided into three treatment groups using computer-generated randomization. Group A patients (n = 30) were given curcumin tablet (300 mg) twice daily, Group B patients (n = 30) received lycopene capsules (8 mg) twice daily, and for Group C (n = 30), placebo capsules were given once daily for a period of six months. Read More

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http://dx.doi.org/10.1111/odi.12947DOI Listing
July 2018
3 Reads

Temporomandibular joint changes in oral submucous fibrosis- A magnetic resonance imaging study.

J Clin Exp Dent 2018 Jul 1;10(7):e673-e680. Epub 2018 Jul 1.

Associate Professor- Department of Radiology and Imaging Sciences, Sri Ramachandra Medical College and Research Institute, Chennai, India.

Background: The aim of this study was to assess the Temporomandibular joint changes as a consequence of varying degrees of restricted mouth opening in Oral Submucous Fibrosis patients.

Material And Methods: The study Population was divided into 2 groups namely Group C- 40 TMJ's of 20 age and gender matched healthy controls and Group P- 40 TMJ's of 20 OSMF patients who were further subdivided into Group II,III,IV based on their restriction in mouth opening. MRI of bilateral TMJ was obtained in closed mouth position. Read More

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http://dx.doi.org/10.4317/jced.54643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057076PMC
July 2018
2 Reads

Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis.

Int J Dent 2018 26;2018:3472087. Epub 2018 Jun 26.

Department of Nutritional Sciences, College of Natural Sciences, The University of Texas at Austin, 103 W. 24th St. A2703, Austin, TX 78712, USA.

Oral submucous fibrosis (OSF) is a potentially malignant disorder which causes fibrosis and inflammation of the oral mucosa. Studies have reported altered levels of trace elements in oral submucous fibrosis subjects, but findings have been inconsistent. The objective of this research is to perform a meta-analysis to summarize studies that report zinc (Zn), copper (Cu), and iron (Fe) in patients, with and without OSF. Read More

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http://dx.doi.org/10.1155/2018/3472087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038491PMC
June 2018
1 Read

Growth-regulated oncogene-α from oral submucous fibrosis fibroblasts promotes malignant transformation of oral precancerous cells.

J Oral Pathol Med 2018 Oct 6;47(9):880-886. Epub 2018 Aug 6.

Institutes of Oral Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Background: Oral squamous cell carcinoma (OSCC) is a common human malignancy and is usually preceded by the oral precancerous lesions. Oral submucous fibrosis (OSF) is one of the oral precancerous lesions with high incidence of malignant transformation. In addition to cancer cells, cancer-associated fibroblasts in the tumor microenvironment are correlated with cancer progression, but the role of fibroblasts from OSF in tumorigenesis and progression is still unknown. Read More

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http://dx.doi.org/10.1111/jop.12768DOI Listing
October 2018
3 Reads

Ki67, CD105, and α-SMA expression supports the transformation relevant dysplastic features in the atrophic epithelium of oral submucous fibrosis.

PLoS One 2018 12;13(7):e0200171. Epub 2018 Jul 12.

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

Background: The grading of oral epithelial dysplasia is not possible in the atrophic epithelium of oral submucous fibrosis (OSMF). Recently, we found that features such as increased basal cell layer hyperplasia, abnormal superficial mitosis, increased nuclear-cytoplasmic ratio, increased nuclear size, and hyperchromasia represent transformation-relevant dysplastic features in the atrophic epithelium of OSMF. The presence of these features can be considered a high-risk feature for patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200171PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042727PMC
January 2019
14 Reads
3.234 Impact Factor

miR-200c inhibits the arecoline-associated myofibroblastic transdifferentiation in buccal mucosal fibroblasts.

J Formos Med Assoc 2018 Sep 27;117(9):791-797. Epub 2018 Jun 27.

Department of General Surgery, Changhua Christian Hospital, Changhua, Taiwan. Electronic address:

Background/purpose: MicroRNA-200c (miR-200c) recently emerged as an important regulator of tumorigenesis and cancer metastasis, however, its role in regulating oral submucous fibrosis (OSF) remains unknown. In this study, we investigated the functional role of miR-200c in myofibroblastic differentiation activity and identified its potential target.

Methods: qRT-PCR was applied to assess the expression of miR-200c in OSF tissues and fibrotic buccal mucosal fibroblasts (fBMFs). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183028
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http://dx.doi.org/10.1016/j.jfma.2018.05.016DOI Listing
September 2018
9 Reads

Areca nut trade, globalisation and its health impact: perspectives from India and South-east Asia.

Perspect Public Health 2018 Jun 1:1757913918785398. Epub 2018 Jun 1.

Professor Emeritus, College of Dentistry and Global Health Studies, The University of Iowa, Iowa City, IA, USA.

Aim: Areca nut (AN) is consumed globally by 600 million people, and 10%-20% of the world population uses betel quid, a preparation containing areca nut. India and other South-east Asian countries are the largest consumers of AN in the world. The aim of this article is to review the economic impact and oral health effects of the consumption of AN. Read More

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http://journals.sagepub.com/doi/10.1177/1757913918785398
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http://dx.doi.org/10.1177/1757913918785398DOI Listing
June 2018
8 Reads