1,315 results match your criteria Oral Submucous Fibrosis


Impact of Oral Submucous Fibrosis on Quality of Life: A Cross-Sectional Study.

J Maxillofac Oral Surg 2019 Jun 4;18(2):260-265. Epub 2018 May 4.

4Department of Public Health Dentistry, AIIMS, Jodhpur, Rajasthan India.

Background: Oral submucous fibrosis (OSMF) is a chronic disease of the oral cavity which presents clinically with burning sensation, leathery consistency of oral mucosa with palpable fibrous bands leading to reduced mouth opening. Though the evaluation of quality of life (QOL) in health care is gaining importance, researches regarding the evaluation of QOL in OSMF individuals are very sparse.

Aim: The aim of the present study is to evaluate the QOL assessment in OSMF patients through WHOQOL-BREF questionnaire. Read More

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http://link.springer.com/10.1007/s12663-018-1114-3
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http://dx.doi.org/10.1007/s12663-018-1114-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441450PMC
June 2019
1 Read

Comparison of histochemical staining techniques for detecting mast cells in oral lesions.

Biotech Histochem 2019 Apr 15:1-10. Epub 2019 Apr 15.

a Department of Oral Pathology and Microbiology , Maratha Mandal's NGH Institute of Dental Sciences and Research Centre , Belgaum , India.

Mast cells are large cells with granular cytoplasm that participate in wound healing, angiogenesis and defense against pathogens. They also contribute to inflammation by initiating innate and acquired immunity. The granules of these cells exhibit characteristic staining properties. Read More

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http://dx.doi.org/10.1080/10520295.2019.1597986DOI Listing

Insight into verruciform xanthoma with oral submucous fibrosis: Case report and review of literature.

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):43-48

Department of Oral Medicine and Radiology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Dilsukhnagar, Hyderabad, Telangana, India.

Verruciform xanthoma (VX) is a rare benign mucocutaneous verrucopapillary lesion, which mainly involves masticatory mucosa and gingiva. Clinically, it presents as a solitary, sessile or pedunculated, white- or yellow-white-colored growth with a pebbled surface, hence often misdiagnosed as papilloma. The hallmark of histological diagnosis is the presence of foam cells or xanthoma cells confined to the connective tissue papillae. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_210_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421923PMC
February 2019
5 Reads

Study of oral potentially malignant disorders related to various risk factors amongst the patients attending hospitals in Bhopal, India.

Med Pharm Rep 2019 Jan 15;92(1):66-71. Epub 2019 Jan 15.

Department of Oral Medicine and Radiology, College of Dental Sciences and Hospital, Amargadh, District - BhavnagarGujarat, India.

Background And Aims: Oral potentially malignant disorders constitute one of the major oral health problems in India. Few studies have been undertaken on potentially malignant disorders in central India, specifically in Bhopal. Hence the present study was conducted to assess the oral potentially malignant disorders in the patients attending hospitals of Bhopal, India. Read More

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http://dx.doi.org/10.15386/cjmed-906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448500PMC
January 2019

Role of autophagy induced by arecoline in angiogenesis of oral submucous fibrosis.

Arch Oral Biol 2019 Mar 28;102:7-15. Epub 2019 Mar 28.

Centre of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Objectives: To detect the expression of protein light chain 3 (LC3) and p62-SQSTM1 (p62) in the lamina propria of oral submucous fibrosis (OSF) and to determine the association of autophagy with OSF. To investigate the role of autophagy in angiogenesis of human umbilical vein endothelial cells (HUVECs) and to assess whether this effect was induced by arecoline.

Methods: LC3 and p62 expression was detected in OSF tissue through immunohistochemistry (IHC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039969193006
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http://dx.doi.org/10.1016/j.archoralbio.2019.03.021DOI Listing
March 2019
9 Reads

Comparison of generic and condition-specific oral health-related quality of life instruments in patients with oral submucous fibrosis.

Qual Life Res 2019 Apr 1. Epub 2019 Apr 1.

Department of Oral Pathology & Microbiology, Dr. D.Y. Patil Dental College & Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India.

Purpose: With the growing interest in health economics, there is a demand for best valid instrument to assess quality of life (QoL) in patients with oral submucous fibrosis (OSF). The objective of this study was to compare the convergent and discriminative properties of the condition-specific OHRQoL-OSF and generic OHIP-14 in OSF patients.

Methods: The OHRQoL-OSF and OHIP-14 instruments were administered concurrently to 300 clinically diagnosed OSF patients. Read More

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http://dx.doi.org/10.1007/s11136-019-02176-yDOI Listing

Risk factors associated with oral manifestations and oral health impact of gastro-oesophageal reflux disease: a multicentre, cross-sectional study in Pakistan.

BMJ Open 2019 Mar 30;9(3):e021458. Epub 2019 Mar 30.

Department of Prosthodontics and Implantology, King Faisal University, Al-Hasa, Saudi Arabia.

Objective: Gastro-oesophageal reflux disease (GORD) is a relatively common disorder and manifests with extraoesophageal symptoms, such as dental erosions (DE), cough, laryngitis, asthma, and oral soft- and hard-tissue pathologies. This study aimed (1) to identify oral soft and hard-tissue changes in patients with GORD and (2) to evaluate these oral changes as indices for assessing GORD and its severity.

Setting: This cross-sectional study was conducted at four major tertiary care government hospitals, in two metropolitan cities of Pakistan. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2017-02145
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http://dx.doi.org/10.1136/bmjopen-2017-021458DOI Listing
March 2019
5 Reads
2.063 Impact Factor

miR-1246 as a therapeutic target in oral submucosa fibrosis pathogenesis.

J Formos Med Assoc 2019 Mar 28. Epub 2019 Mar 28.

School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan. Electronic address:

Background/purpose: Oral submucous fibrosis (OSF) is a precancerous condition of oral cancer with a complex etiology. Our previous work has demonstrated that non-coding RNA miR-1246 contributes to the cancer stemness of oral cancer. In the current study, we sought to investigate the effect of the inhibition of miR-1246 on the oral fibrogenesis. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.02.014DOI Listing
March 2019
2 Reads

Oral potentially malignant disorders: clinical diagnosis and current screening aids: a narrative review.

Eur J Cancer Prev 2019 Mar 27. Epub 2019 Mar 27.

Department of Internal Medicine, University of Tennessee Health Science Centre, Memphis, Tennessee, USA.

Around 300 000 patients are estimated to have oral cancer worldwide annually, and the incidence is higher in South Asian countries. In 2005, at the Congress of WHO, the term potentially malignant disorder (PMD)/lesion was suggested as a replacement for premalignant oral lesions and conditions. PMDs are those lesions of the oral mucosa that are at an increased risk of malignant transformation compared with the healthy mucosa. Read More

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http://dx.doi.org/10.1097/CEJ.0000000000000510DOI Listing

Arecoline suppresses epithelial cell viability through the Akt/mTOR signaling pathway via upregulation of PHLPP2.

Toxicology 2019 May 22;419:32-39. Epub 2019 Mar 22.

Xiangya School of Stomatology, Central South University, Changsha 410008, Hunan, China; Department of Oral and Maxillofacial Surgery, Xiangya Stomatological Hospital, Central South University, Changsha 410008, Hunan, China. Electronic address:

Arecoline, the major active ingredient of the betel nut, is involved in the pathogenesis of oral submucous fibrosis. However, the underlying mechanism of this pathogenesis remains unclear. In this study, we found that arecoline suppresses the cell proliferation of the HaCaT epithelial cell and induces cell cycle arrest at the G1/S phase with an IC50 of 50 μg/mL. Read More

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http://dx.doi.org/10.1016/j.tox.2019.03.006DOI Listing

EZBite open-mouth device: A new treatment option for oral submucous fibrosis-related trismus.

J Dent Sci 2018 Mar 7;13(1):80-81. Epub 2017 Aug 7.

Division of Oral and Maxillofacial Surgery, Tri-Service General Hospital, Taipei, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.jds.2017.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388846PMC

Hematinic deficiencies and anemia in gastric parietal cell antibody-positive and -negative oral submucous fibrosis patients.

J Dent Sci 2018 Mar 21;13(1):68-74. Epub 2018 Mar 21.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.

Background/purpose: Previous studies showed that approximately 13-15% of male oral submucous fibrosis (OSF) patients are serum gastric parietal cell antibody (GPCA)-positive. This study assessed whether serum GPCA or OSF itself was a significant factor that caused hematinic deficiencies and anemia statuses in GPCA-positive or GPCA-negative OSF patients (GPCA/OSF and GPCA/OSF patients).

Materials And Methods: The frequencies of macrocytosis (mean corpuscular volume or MCV ≧ 100 fL) and blood hemoglobin (Hb), iron, vitamin B12 and folic acid deficiencies were determined and compared between any two of the four groups of 149 male OSF, 23 male GPCA/OSF, and 126 male GPCA/OSF patients and 149 age-matched male healthy control subjects. Read More

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http://dx.doi.org/10.1016/j.jds.2018.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388861PMC
March 2018
1 Read

Nano Drug Delivery in Treatment of Oral Cancer, A Review of the Literature.

Curr Drug Targets 2019 Mar 19. Epub 2019 Mar 19.

Department of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh. India.

Oral cancer (OC) is a serious and a growing problem which constitutes a huge burden on people in more and less economically developed countries alike. The scenario is clearly depicted from the increase in expected number of new cases in US diagnosed with OC from 49,670 people in 2016, to 49,750 cases in 2017. The situation is even more alarming in India, with 75,000 to 80,000 new cases being reported every year, thus making it the OC capital of the world. Read More

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http://www.eurekaselect.com/170833/article
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http://dx.doi.org/10.2174/1389450120666190319125734DOI Listing
March 2019
6 Reads

Oral Epithelial Dysplasia and Premalignancy.

Authors:
Sook-Bin Woo

Head Neck Pathol 2019 Mar 18. Epub 2019 Mar 18.

Harvard School of Dental Medicine, Boston, MA, USA.

Leukoplakia and erythroplakia are two entities under the moniker of "oral potentially malignant disorders" that are highly associated with the presence of oral epithelial dysplasia (OED) at first biopsy, while lesions of submucous fibrosis develop OED after being present for years. Importantly, traumatic/frictional keratoses are often mistaken clinically for leukoplakia and it is important for the pathologist to recognize and report them as such. The features of OED have been well-described and other architectural features will be discussed here, in particular verrucous and papillary architecture, bulky epithelial proliferation and epithelial atrophy. Read More

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http://dx.doi.org/10.1007/s12105-019-01020-6DOI Listing
March 2019
2 Reads

Arctigenin Reduces Myofibroblast Activities in Oral Submucous Fibrosis by LINC00974 Inhibition.

Int J Mol Sci 2019 Mar 16;20(6). Epub 2019 Mar 16.

School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan.

Oral submucous fibrosis (OSF) is an oral precancerous condition associated with the habit of areca nut chewing and the TGF-β pathway. Currently, there is no curative treatment to completely heal OSF, and it is imperative to alleviate patients' symptoms and prevent it from undergoing malignant transformation. Arctigenin, a lignan extracted from , has been reported to have a variety of pharmacological activities, including anti-fibrosis. Read More

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http://dx.doi.org/10.3390/ijms20061328DOI Listing

Socio-Economic Implications Of A Younger Aged Female Predilection In Malignant Transformation Of Oral Sub Mucous Fibrosis.

J Ayub Med Coll Abbottabad 2019 Jan-Mar;31(1):16-20

Ziauddin College of Dentistry, Ziauddin University, Karachi, Pakistan.

Background: This study was conducted to determine the age, gender and pattern of associated chewing habits among cases of oral squamous cell carcinoma (OSCC) presenting with, (OSMFCa) and without, (Ca-OSMF) pre-existing clinical oral submucous fibrosis in Karachi, Pakistan.

Methods: A cross sectional, multi centric study of (n=1009) cases with histologically confirmed oral squamous cell carcinoma seen at both public, private tertiary care hospitals and clinics over a period of eight years. A non-probability convenience sampling was used for selection of cases. Read More

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March 2019
2 Reads

Tooth and Advanced Oral Submucous Fibrosis Obscuring Buccal Squamous Cell Carcinoma: A Case Report and Literature Review.

Cureus 2018 Dec 31;10(12):e3802. Epub 2018 Dec 31.

Oral Medicine and Radiology, Sathyabama Dental College and Hospital, Chennai, IND.

Oral squamous cell carcinoma is a leading cause of mortality due to late diagnosis in India and most other developing countries. Buccal squamous cell carcinoma is almost always preceded by premalignant conditions that include leukoplakia, erythroplakia, oral lichen planus, and submucous fibrosis of the oral cavity. Hence, these patients warrant regular screening by oral health care professionals and proper monitoring for any dysplastic changes. Read More

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http://dx.doi.org/10.7759/cureus.3802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402749PMC
December 2018
1 Read

Assessment of salivary endothelin-1 in patients with leukoplakia, submucous fibrosis, oral cancer and healthy individuals - a comparative study.

J Stomatol Oral Maxillofac Surg 2019 Mar 9. Epub 2019 Mar 9.

Faculty of Dental Sciences, Ramaiah University of Applied Sciences, India.

Background: Oral cancer is one of the highly prevalent cancers worldwide being. According to data of GLOBOCAN 2018, the estimated incidence, mortality and 5-year survival rates due to lip, oral cavity and salivary gland cancer in world is (2.0%), (0. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.02.024DOI Listing
March 2019
2 Reads

Revisiting and revising the definition of oral submucous fibrosis.

Oral Oncol 2019 Mar 7. Epub 2019 Mar 7.

Department of Oral Pathology, Manipal College of Dental Sciences, Manipal Academy of Higher Education (MAHE), Manipal 576104, India. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2019.03.004DOI Listing

Evaluation of Serum C-Reactive Protein Levels in Oral Premalignancies and Malignancies: A Comparative Study.

J Dent (Tehran) 2018 Nov;15(6):358-364

Senior Lecturer, Department of Oral Medicine & Radiology, G Pullareddy Dental College & Hospital, Kurnool, Andhra Pradesh, India.

Objectives: The aim was to evaluate and compare pretreatment serum C-reactive protein (CRP) levels in patients with oral premalignancies and malignancies with that in healthy controls.

Materials And Methods: The study sample consisted of 90 patients of both genders. The subjects were divided into three groups. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399459PMC
November 2018
5 Reads

Prevalence of oral mucosal lesions among smokeless tobacco usage: A cross-sectional study.

Indian J Cancer 2018 Oct-Dec;55(4):404-409

Department of Oral Pathology and Microbiology, SDM College of Dental Sciences and Hospital, Sattur, Dharwad, Karnataka, India.

Background: Tobacco use is one of the most prevalent forms of habit and associated with development of potential malignant disorders. The aim of the present study was to investigate the prevalence and distribution of oral mucosal lesions (OMLs) among smokeless tobacco users.

Materials And Methods: This is a hospital-based cross-sectional study. Read More

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http://dx.doi.org/10.4103/ijc.IJC_178_18DOI Listing
March 2019
7 Reads

Evaluation of Gustatory Function in Oral Submucous Fibrosis Patients and Gutka Chewers

Asian Pac J Cancer Prev 2019 Feb 26;20(2):569-573. Epub 2019 Feb 26.

Department of Oral Medicine and Radiology, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India. Email:

Aim: The aim of the study is to assess and compare taste perception among Oral submucous fibrosis (OSMF) patients, Gutka chewers without OSMF and healthy subjects. Materials and methods: Ninety subjects (30 OSMF, 30 Gutka chewers without OSMF and 30 controls) were enrolled in the study for assessing taste perception by filter paper strips impregnated with different taste qualities. Taste perception assessment was also done in stage I, II and III OSMF subjects. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.2.569DOI Listing
February 2019
2 Reads

Habit History in Oral Submucous Fibrosis: Have We Over Emphasized?

Asian Pac J Cancer Prev 2019 Feb 26;20(2):451-455. Epub 2019 Feb 26.

Department of Oral Medicine and Radiolog , The Oxford dental College, Bengaluru, India. Email:

Aim: Correlation of habit duration and frequency with clinical grading and histopathologic grouping of oral submucous fibrosis (OSMF). Materials and methods: 48 patients with OSMF were included in the study. Detailed history of each patient, clinical profile and habit history were recorded. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.2.451DOI Listing
February 2019
1 Read

Efficacy of curcumin for management of oral submucous fibrosis: a systematic review of randomized clinical trials.

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Apr 16;127(4):300-308. Epub 2019 Jan 16.

Department of Oral Medicine and Diagnostic Science, Al Farabi Colleges, Riyadh, Kingdom of Saudi Arabia. Electronic address:

Objectives: Oral submucous fibrosis (OSF) is a chronic debilitating disease that has a high risk of malignant transformation. Management of OSF is quite challenging, with no definitive cure being available. This systematic review assessed the available evidence for using curcumin for pain alleviation and clinical improvement in patients with OSF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22124403193001
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http://dx.doi.org/10.1016/j.oooo.2019.01.010DOI Listing
April 2019
1 Read

Oral submucous fibrosis: A clinicopathological study of 674 cases in China.

J Oral Pathol Med 2019 Feb 4. Epub 2019 Feb 4.

Department of oral pathology, Xiangya Stomatological Hospital, Central South University, Changsha, Hunan, China.

Background: Oral submucous fibrosis (OSF) has been reported frequently in India and other countries in South Asia. There are few reports on the clinicopathological features of OSF in China, where OSF is an epidemic. This study analyses the clinicopathological features of OSF in Hunan Province, China. Read More

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http://dx.doi.org/10.1111/jop.12836DOI Listing
February 2019
1 Read

Stress activated p38 MAPK regulates cell cycle via AP-1 factors in areca extract exposed human lung epithelial cells.

Cytotechnology 2019 Apr 2;71(2):507-520. Epub 2019 Feb 2.

Department of Microbiology and Biotechnology, Bangalore University, Jnana Bharathi, Bengaluru, Karnataka, 560 056, India.

Areca nut chewing habits are associated with several oral manifestations like leukoplakia, submucous fibrosis and oral squamous cell carcinoma. Although numerous evidence on areca toxicity is known but the mechanistic pathway of disease causation is to be studied. Aqueous areca nut extract treated A549 cells showed reduced cell viability by 48 h with IC value of 0. Read More

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http://dx.doi.org/10.1007/s10616-019-00297-3DOI Listing
April 2019
3 Reads
1.752 Impact Factor

Differential expression of salivary S100A7 in oral submucous fibrosis.

Saudi Dent J 2019 Jan 24;31(1):39-44. Epub 2018 Sep 24.

Department of Periodontology, Faculty of Dentistry, Ziauddin University, 75600 Karachi, Pakistan.

Aim: To investigate the expression of salivary S100A7 levels among patients with oral submucous fibrosis (OSF) and healthy controls.

Method: A total number of 60 participants were included in the study (30 OSF cases and 30 healthy controls). Demographic data was collected using a structured baseline questionnaire. Read More

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http://dx.doi.org/10.1016/j.sdentj.2018.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349954PMC
January 2019

Is Periodontitis Independently Associated with Potentially Malignant Disorders of the Oral Cavity?

Asian Pac J Cancer Prev 2019 Jan 25;20(10):283-287. Epub 2019 Jan 25.

Department of Public Health Dentistry, Sharavathi Dental College and Hospital, Shimoga, India. Email:

Objective: To examine if periodontitis is independently associated with oral potentially malignant disorders (OPMD) in a rural Indian adult population aged 35-54 years. Methods: A population-based cross-sectional study was conducted in rural India from 2011 to 2012. Multistage stratified cluster random sampling was followed to recruit 1401 participants aged 35-54 years. Read More

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http://journal.waocp.org/article_80973.html
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http://dx.doi.org/10.31557/APJCP.2019.20.1.283DOI Listing
January 2019
6 Reads

Impact of socioeconomic inequalities on quality of life in oral submucous fibrosis patients.

Future Oncol 2019 Mar 23;15(8):875-883. Epub 2019 Jan 23.

Department of Oral Pathology & Microbiology, Dr DY Patil Dental College & Hospital, Dr DY Patil Vidyapeeth, Pune, Maharashtra, India.

Aim: The purpose of this study was to analyze the impact of socioeconomic characteristics on oral health-related quality of life (OHRQoL) in patients with oral submucous fibrosis (OSF).

Methods:  A total of 300 OSF patients' quality of life (QoL) data were obtained using OHRQoL-OSF and global self ratings of oral health and overall wellbeing. The socioeconomic status (SES) of participants was analyzed by using modified Kuppuswamy scale. Read More

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http://dx.doi.org/10.2217/fon-2018-0645DOI Listing
March 2019
2.477 Impact Factor

Insight on the relationship of ABO blood grouping associated with oral premalignant lesions, conditions and inherited oral cancer syndromes.

J Exp Ther Oncol 2019 Jan;13(1):59-63

Resident, MOH, Department of Oral and Maxillofacial Surgery, King Khalid Hospital, Najran, Kingdom of Saudi Arabia.

Background: Risk factors such as chronic use of tobacco, smoking and alcohol consumption of individual's lifestyle may possibly influence the significant role in the etiopathogenesis of precancerous lesions (PL) and Conditions (PC) and lead to oral cancer. Previous studies have revealed that genetic factors have contributed to a remarkable extent in the development of this chronic disease. Limited studies have confirmed that ABO blood groups remain reportedly possible genetic factor to the specific disease such as oral malignant. Read More

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January 2019

Variants in FAT1 and COL9A1 genes in male population with or without substance use to assess the risk factors for oral malignancy.

PLoS One 2019 18;14(1):e0210901. Epub 2019 Jan 18.

Environment-Omics-Disease Research Center, China Medical University Hospital, Taichung, Taiwan.

A number of genetic variants were suggested to be associated with oral malignancy, few variants can be replicated. The aim of this study was to identify significant variants that enhanced personal risk prediction for oral malignancy. A total of 360 patients diagnosed with oral squamous cell carcinoma, 486 controls and 17 newly diagnosed patients with OPMD including leukoplakia or oral submucous fibrosis were recruited. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210901PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338366PMC
January 2019
11 Reads

A novel clinical protocol for therapeutic intervention in oral submucous fibrosis: An evidence based approach.

J Oral Maxillofac Pathol 2018 Sep-Dec;22(3):382-391

Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.

Oral submucous fibrosis (OSMF) is a chronic, progressive, debilitating, scarring and crippling disorder of the oral cavity. It is a potentially malignant oral disease which predominantly affects people of South and Southeast Asia, especially Indian subcontinent, where chewing of areca nut and its commercial preparation is rampant. However, due to increase in immigration of people from the Indian subcontinent, the health professionals in many developed countries do come across this disease very often. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_223_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306594PMC
January 2019
9 Reads

Estimation of serum hepcidin in oral submucous fibrosis before and after supplementation with oral iron: A randomized control clinical trial.

J Oral Maxillofac Pathol 2018 Sep-Dec;22(3):303-306

Department of Oral Medicine and Radiology, Sri Rajiv Gandhi College of Dental Sciences and Hospital, Bengaluru, Karnataka, India.

Background: Iron-deficiency anemia is synonymous with oral submucous fibrosis (OSMF). The cause for the same has not been ascertained yet. OSMF by way of anemia of chronic disease could be a probable cause of iron deficiency. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_112_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306602PMC
January 2019
3 Reads

Ultrasonographic evaluation of submucosal thickness in oral submucous fibrosis patients: a cross-sectional study.

Pol J Radiol 2018 14;83:e280-e288. Epub 2018 Jun 14.

V.S.P.M. Dental College and Research Center, Nagpur, India.

Purpose: To evaluate the role of ultrasonography in oral submucous fibrosis (OSMF) patients.

Material And Methods: A total of 150 subjects were divided equally into six groups (Group I: 25 healthy subjects; Group II: 25 healthy subjects with habit; Group III: 25 OSMF stage I; Group IV: 25 OSMF stage II; Group V: 25 OSMF stage III; and Group VI: 25 stage OSMF IVA). The grading of OSMF were done according the clinical classification given by Khanna and Andrade (2005). Read More

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http://dx.doi.org/10.5114/pjr.2018.76795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323594PMC

A potential new oral mapping (OM) method in the clinical evaluation and documentation of oral submucous fibrosis-A prospective clinical crossover study.

J Oral Pathol Med 2019 Jan 3. Epub 2019 Jan 3.

Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK.

Background: Despite much research, there is a lack of a definite protocol or method for documenting oral submucous fibrosis (OSMF) site presentation. In this study, we propose a new potential oral mapping (OM) method and evaluated its use in recording OSMF-affected mucosal sites.

Methods: Fifty OSMF patients were evaluated by 15 primary care dental practitioners using both, a conventional subjective recording method and a new OM method, to document the degree of involvement of affected oral mucosa with a crossover study design. Read More

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http://doi.wiley.com/10.1111/jop.12821
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http://dx.doi.org/10.1111/jop.12821DOI Listing
January 2019
10 Reads

Prospective cross-sectional study assessing prevalence and factors affecting trismus after multimodal treatment for oral cancers.

Head Neck 2019 Feb 12;41(2):286-290. Epub 2018 Dec 12.

Department of Head and Neck Surgery, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Background: Trismus is a common complication following treatment for oral cancers. However, its incidence in site-specific cancers is not adequately studied. The purpose of this study was to assess the prevalence and risk factors associated with trismus in treated patients with oral cancer. Read More

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http://dx.doi.org/10.1002/hed.25464DOI Listing
February 2019
5 Reads

Evaluation of mast cells in oral premalignant and malignant lesions: A histochemical study.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):184-190

Department of Oral Medicine and Radiology, Pacific Dental College, Udaipur, Rajasthan, India.

Introduction: Oral leukoplakia, oral submucous fibrosis, and oral lichen planus are the precancerous or potentially malignant lesions and conditions whereas oral squamous cell carcinoma (OSCC) is a cancerous or malignant lesion of the oral cavity. They have characteristic clinical and histopathological features. These diseases not only originate from epithelium but also associated with chronic inflammation juxta-epithellialy. Read More

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http://www.njms.in/text.asp?2018/9/2/184/245349
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http://dx.doi.org/10.4103/njms.NJMS_49_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251297PMC
December 2018
28 Reads

Oral health-related quality of life among male subjects with oral submucous fibrosis in a tertiary care hospital.

Indian J Public Health 2018 Oct-Dec;62(4):271-276

Senior Resident, Oral Health Sciences Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, Union Territory, India.

Background: Oral submucous fibrosis is very common in Asia. It has many deleterious effects on individual's oral functions. Thus, there is a need to assess the effect of oral submucous fibrosis on quality of life. Read More

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http://www.ijph.in/text.asp?2018/62/4/271/247220
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http://dx.doi.org/10.4103/ijph.IJPH_179_17DOI Listing
December 2018
1 Read

Oral submucous fibrosis - Is it time to modify the definition?

Oral Oncol 2018 Dec 24;87:203. Epub 2018 Oct 24.

Department of Oral Medicine and Radiology, The Oxford Dental College, Bangalore, India.

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http://dx.doi.org/10.1016/j.oraloncology.2018.10.025DOI Listing
December 2018

Malignant transformation to oral cancer by subtype of oral potentially malignant disorder: A prospective cohort study of Taiwanese nationwide oral cancer screening program.

Oral Oncol 2018 Dec 24;87:58-63. Epub 2018 Oct 24.

School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Objectives: To elucidate the risk of malignant transformation to invasive oral cancer by subtypes of oral potentially malignant disorders (OPMD) and to examine the independent effects of risk factors, particularly alcohol drinking, by subtype based on a nationwide oral cancer screening program targeting at general population with habits of smoking and/or betel quids chewing.

Materials And Methods: The total of 8501 subjects diagnosed as different subtypes of OPMDs from the Taiwanese screening program between 2004 and 2009 were followed up over time to ascertain the occurrence of invasive oral cancer. The hazard ratios of malignant transformation were estimated by using Cox proportional hazards regression model. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375183038
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http://dx.doi.org/10.1016/j.oraloncology.2018.10.021DOI Listing
December 2018
13 Reads

Immunolocalization of c-Jun in normal mucosa, oral submucous fibrosis, epithelial dysplasia, and oral squamous cell carcinoma: A comparative study.

J Cancer Res Ther 2018 Oct-Dec;14(6):1180-1183

Department of Oral and Maxillofacial Pathology, SDM College of Dental Sciences and Hospital, Dharwad, Karnataka, India.

Background And Objective: c-Jun an activator protein-1 transcription factor component is activated by a variety of extracellular stimuli. Overexpression of c-Jun has been implicated in the pathogenesis of several types of cancer including oral cancer. The aim of this study was to correlate the expression of c-Jun in the normal buccal mucosa (NM), oral submucous fibrosis (OSMF), severe epithelial dysplasia (ED), and well-differentiated squamous cell carcinoma (WDSCC). Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_324_16DOI Listing
February 2019
1 Read

Pathogenesis investigation of miR-199-5p in oral submucous fibrosis based on bioinformatics analysis.

Oral Dis 2019 Mar 19;25(2):456-465. Epub 2018 Dec 19.

Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, China.

Objectives: Fibrosis diseases are one of the leading causes of suffering and death. However, no systematic investigation has been carried out on fibrosis-related genes.

Materials And Methods: By querying PubMed using keywords "fibrosis" and "gene" or "protein," we identified fibrosis-related genes in the last decade. Read More

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http://dx.doi.org/10.1111/odi.13008DOI Listing
March 2019
1 Read

Estimation of serum beta-carotene level in patients suffering from oral submucous fibrosis.

J Exp Ther Oncol 2018 Nov;12(4):267-271

Department of Oral Medicine & Radiology, Government Dental College and Hospital, Aurangabad, Maharashtra, India.

Introduction: Oral submucous fibrosis (OSMF), an insidious disease, has not been widely studied with respect to levels of serum beta-carotene (b-carotene). Hence present study aimed to estimate level of serum beta carotene in patients with OSMF.

Material And Methods: 40 subjects (study subjects) with different grades of OSMF and 40 apparently healthy subjects without OSMF (control subjects with age and sex matched as that of study subjects) were screened for serum b-carotene levels employing Sobel and Snow's method. Read More

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November 2018
14 Reads

LncRNA LINC00974 activates TGF-β/Smad signaling to promote oral fibrogenesis.

J Oral Pathol Med 2019 Feb 9;48(2):151-158. Epub 2018 Dec 9.

School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.

Background: Oral submucous fibrosis (OSF) is a progressive scarring disease and has been considered as a premalignant condition of the oral cavity. However, the detailed molecular mechanisms underlying the pathogenesis of OSF are still unclear.

Method: Here, we examined the expression of a novel long non-coding RNA LINC00974 in OSF and investigated its function role in myofibroblast transdifferentiation. Read More

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http://doi.wiley.com/10.1111/jop.12805
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http://dx.doi.org/10.1111/jop.12805DOI Listing
February 2019
43 Reads
1.870 Impact Factor

Evaluation of the Prevalence of Oral Mucosal Lesions in a Population of Eastern Coast of South India.

J Int Soc Prev Community Dent 2018 Sep-Oct;8(5):396-401. Epub 2018 Oct 8.

Department of Public Health Dentistry, Sibar Institute of Dental Sciences and Research, Guntur, Andhra Pradesh, India.

Objective/aim: The aim of this study is to measure the association between oral mucosal lesions (OMLs) and habit of tobacco and alcohol in the population of Guntur city, Andhra Pradesh, South India.

Material And Method: A cross-sectional study was conducted on 300 participants in Guntur city with the habit of tobacco and alcohol consumption in various forms who were selected by stratified cluster random sampling technique. Guntur city was divided into four zones, that is, North, East, South, and West; and two administrative wards were randomly selected from each zone as clusters. Read More

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http://www.jispcd.org/text.asp?2018/8/5/396/242866
Publisher Site
http://dx.doi.org/10.4103/jispcd.JISPCD_207_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187880PMC
October 2018
4 Reads

An Evaluation of Clinical and Histopathological Aspects of Patients with Oral Submucous Fibrosis in the Background of Oral Squamous Cell Carcinoma.

Biomed Res Int 2018 9;2018:4154165. Epub 2018 Oct 9.

Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.

Background: The behavior and prognosis of oral squamous cell carcinoma (OSCC) is presumably different in patients with oral submucous fibrosis (OSF). The objective of this study was to assess the effects of demographic features, habits, and histopathological features in the transformation of OSF to OSCC.

Methods: Data were extracted from the archives and histopathological evaluation and presence of nodal metastasis were recorded. Read More

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https://www.hindawi.com/journals/bmri/2018/4154165/
Publisher Site
http://dx.doi.org/10.1155/2018/4154165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198553PMC
February 2019
21 Reads

Extended nasolabial flap in oral submucous fibrosis - our modification.

Authors:
S Sidana

J Stomatol Oral Maxillofac Surg 2019 Feb 27;120(1):71-73. Epub 2018 Oct 27.

Department of Oral and Maxillofacial Surgery MGM Dental College and Hospital, Kamothe, Navi Mumbai, India. Electronic address:

Nasolabial Flaps are the most popular and commonly used flap in reconstructing mucosal defect left by fibrous band excision in developing countries like India where free flap expertise is not easily available and affordable by poor patients. Extended nasolabial flaps have been used in oral sub mucous fibrosis to cover mucosal defect. Normally these flaps are not wide enough to cover the mucosal defect left by fibrous band excision. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24687855183021
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http://dx.doi.org/10.1016/j.jormas.2018.10.003DOI Listing
February 2019
5 Reads

Delineating metabolic dysfunction in cellular metabolism of oral submucous fibrosis using H nuclear magnetic resonance spectroscopy.

Arch Oral Biol 2019 Jan 21;97:102-108. Epub 2018 Oct 21.

School of Medical Science and Technology, IIT Kharagpur, India.

Objective: To delineate the metabolism involved in oral submucous fibrosis progression towards carcinogenesis by H nuclear magnetic resonance spectroscopy.

Methods: The proposed study was designed using H-NMR by comparing the metabolites in the serum sample of oral submucous fibrosis (n = 20) compared to the normal group (n = 20) using H nuclear magnetic resonance spectroscopy. Various statistical analysis like multivariate statistical analysis, Principle component analysis, Partial least squares Discriminant Analysis, Hierarchical cluster analysis was applied to analyze potential serum metabolites. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2018.10.016DOI Listing
January 2019
2 Reads

Collagen Membrane Over Buccal Fat Pad Versus Buccal Fat Pad in Management of Oral Submucous Fibrosis: A Comparative Prospective Study.

J Maxillofac Oral Surg 2018 Dec 11;17(4):482-487. Epub 2017 Sep 11.

Department of Oral and Maxillofacial Surgery, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.

Objective: The objective of this study was to assess the effectiveness of collagen membrane as biological dressing over buccal fat pad (BFP) during crucial postoperative healing phase in the surgical management of oral submucous fibrosis (OSMF).

Study Design: The study comprised of 40 patients of OSMF of group IVa (Khanna and Andrade). Patients were randomly divided in two groups (20 patients in each group). Read More

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http://link.springer.com/10.1007/s12663-017-1041-8
Publisher Site
http://dx.doi.org/10.1007/s12663-017-1041-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181840PMC
December 2018
9 Reads

Aloe vera in treatment of oral submucous fibrosis: A systematic review and meta-analysis.

J Oral Pathol Med 2019 Feb 7;48(2):99-107. Epub 2018 Nov 7.

Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

The management of oral submucous fibrosis (OSF) is quite challenging, and as yet, no effective therapy is available for its management. The present systematic review and meta-analysis sought to assess the effectiveness of aloe vera in alleviating pain and clinical signs of OSF. A comprehensive search in PubMed/Medline, Scopus, and Web of Science databases was conducted to identify the relevant randomized clinical trials. Read More

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http://dx.doi.org/10.1111/jop.12789DOI Listing
February 2019
1.870 Impact Factor