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    1099 results match your criteria Oral Submucous Fibrosis

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    Low-power laser irradiation inhibits arecoline-induced fibrosis: an in vitro study.
    Int J Oral Sci 2017 Feb 24. Epub 2017 Feb 24.
    School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Oral submucous fibrosis (OSF) is a potentially malignant disorder that is characterized by a progressive fibrosis in the oral submucosa. Arecoline, an alkaloid compound of the areca nut, is reported to be a major aetiological factor in the development of OSF. Low-power laser irradiation (LPLI) has been reported to be beneficial in fibrosis prevention in different damaged organs. Read More

    Betel nut chewing, oral premalignant lesions, and the oral microbiome.
    PLoS One 2017 22;12(2):e0172196. Epub 2017 Feb 22.
    University of Guam Cancer Research Center, Mangilao, Guam, United States of America.
    Oral cancers are attributed to a number of causal agents including tobacco, alcohol, human papillomavirus (HPV), and areca (betel) nut. Although betel nut chewing has been established as an independent cause of oral cancer, the mechanisms of carcinogenesis are poorly understood. An investigation was undertaken to evaluate the influence of betel nut chewing on the oral microbiome and oral premalignant lesions. Read More

    Serum Iron and Haemoglobin Estimation in Oral Submucous Fibrosis and Iron Deficiency Anaemia: A Diagnostic Approach.
    J Clin Diagn Res 2016 Dec 1;10(12):ZC54-ZC58. Epub 2016 Dec 1.
    Lecturer, Department of Oral Medicine and Radiology, Goa Dental College and Hospital , Bambolim, Goa, India .
    Introduction: Oral Submucous Fibrosis (OSMF) is a premalignant condition with potential malignant behaviour characterized by juxta-epithelial fibrosis of the oral cavity. In the process of collagen synthesis, iron gets utilized, by the hydroxylation of proline and lysine, leading to decreased serum iron levels. The trace element like iron is receiving much attention in the detection of oral cancer and precancerous condition like OSMF as it was found to be significantly altered in these conditions. Read More

    Recent Updates on Electronic Cigarette Aerosol and Inhaled Nicotine Effects on Periodontal and Pulmonary Tissues.
    Oral Dis 2017 Feb 6. Epub 2017 Feb 6.
    Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.
    E-cigarette derived inhaled nicotine may contribute to the pathogenesis of periodontal and pulmonary diseases in particular via lung inflammation, injurious and dysregulated repair responses. Nicotine is shown to have anti-proliferative properties and affects fibroblasts in vitro, which may interfere in tissue myofibroblast differentiation in e-cig users. This will affect the ability to heal wounds by decreasing wound contraction. Read More

    Oral squamous cell carcinoma in the background of oral submucous fibrosis is a distinct clinico-pathological entity with better prognosis.
    J Oral Pathol Med 2017 Jan 27. Epub 2017 Jan 27.
    Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (M), Wardha, Maharashtra, India, Postal code: - 442001.
    Background: The aim of this study was to compare the clinicopathological features of oral squamous cell carcinoma in the background of oral submucous fibrosis (OSCC-OSMF) and oral squamous cell carcinoma (OSCC).

    Methods: 217 cases of OSCC were retrieved from achieves for the analysis.OSCC-OSMF cases were segregated on the basis of history and clinico-pathological parameters. Read More

    [Clinical effectiveness of salvianolic acid B and triamcinolone acetonide in treatment of oral submucous fibrosis].
    Zhonghua Kou Qiang Yi Xue Za Zhi 2017 Jan;52(1):16-21
    Department of Oral Mucous Disease, Stomatology Center, Affiliate Haikou Hospital of Central South University Xiangya Medical School & Hainan Provincial Stomatology Center, Haikou 570208, China.
    Objective: To evaluate the clinical effectiveness of salvianolic acid B (SA-B) and triamcinolone acetonide (TA) by means of combined intralesional injection in the treatment of oral submucous fibrosis (OSF). Methods: According to clinical findings and symptoms, TA combined with SA-B were consecutively applied intralesionally 1 time weekly for 30 times. Mouth opening degree, color change of the buccal mucosae and numeral increase of the capillary vessels were determined by degree Ⅰ-Ⅳ visual analog scale were evaluated at 12, 24, and 36 months, respectively. Read More

    The Insight for Initiation and Maintenance of Areca nut chewing Habit and its Effects on Oral Health Status among School Age Population in Western Rajasthan, India.
    J Clin Diagn Res 2016 Nov 1;10(11):ZC15-ZC18. Epub 2016 Nov 1.
    Postgraduate Student, Department of Oral and Maxillofacial Pathology, Vyas Dental College and Hospital , Jodhpur, Rajasthan, India .
    Introduction: Areca nut is highly carcinogenic according to International Agency for Research on Cancer (IARC). Its usage is continuously increasing in children and adolescents in India.

    Aim: The aim of the study was to understand the reasons for the development of the areca nut chewing habit at early age. Read More

    Myofibroblasts could be recruited in a chemokine (C-C motif) ligand 2-dependent manner in pathogenesis of oral submucous fibrosis.
    J Oral Pathol Med 2016 Dec 28. Epub 2016 Dec 28.
    Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
    Background: Monocyte chemoattractant protein-1 (CCL2) is a major profibrotic mediator with a proven role in fibrosis of different organs of the body. Recently, increased fibrosis in oral submucous fibrosis (OSMF) is linked with betel quid-related chronic irritation and myofibroblast. Hence, this study is designed to investigate expression of CCL2 in OSMF and its correlation with myofibroblasts. Read More

    Omega 3: a novel treatment agent in oral submucous fibrosis: a pilot study.
    J Oral Pathol Med 2016 Dec 27. Epub 2016 Dec 27.
    Department of Public health dentistry, Dr. D.Y.Patil Dental College & Hospital, DPU, Pune, Maharashtra, India.
    Background: Oral submucous fibrosis (OSF) is a chronic debilitating disease and a premalignant condition of the oral cavity. It is well known for its impervious nature to medical therapy. Omega-3 polyunsaturated fatty acids have been reported to have anti-inflammatory properties. Read More

    Mandibular Canal Widening and Bell's Palsy: Sequelae of Perineural Invasion in Oral Cancer.
    Case Rep Dent 2016 29;2016:3010934. Epub 2016 Nov 29.
    Department of Oral and Maxillofacial Surgery, A.B. Shetty Memorial Institute of Dental Sciences, Mangalore, India.
    Perineural invasion is an underrecognized route of metastatic spread along the nerve bundles within the nerve sheath into the surrounding tissues. It hinders the ability to establish local control as tumour cells can traverse along nerve tracts well beyond the extent of any local invasion rendering them inoperable and unresectable. Perineural invasion is a marker of poor prognosis. Read More

    Breath Alkane as an index of severity for oral submucous fibrosis: A new perspective?
    Med Hypotheses 2017 Jan 16;98:18-20. Epub 2016 Nov 16.
    Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Cosham, Portsmouth PO6 3LY, United Kingdom.
    Oral submucous fibrosis (OSMF) is a devastating disease commonly seen in the Asian subcontinent that results in significant functional morbidity for patients and has a high potential for malignant transformation. Over the last three decades, different diagnostic methods have been described to quantify and grade OSMF severity. Some methods have been used with perceived favorable outcomes although recurrence and malignant transformation remains a problem in many cases, and OSMF presents a major therapeutic challenge. Read More

    Effect of curcumin on the expression of p53, transforming growth factor-β, and inducible nitric oxide synthase in oral submucous fibrosis: A pilot study.
    J Investig Clin Dent 2016 Dec 17. Epub 2016 Dec 17.
    Department of Pathology, Govind Ballabh Pant Hospital, New Delhi, India.
    Aim: The purpose of the present study was to find out the expression of p53, transforming growth factor-β TGF-β), and inducible nitric oxide synthase (iNOS) in oral submucous fibrosis (OSMF), proteins implicated in its pathophysiology, as well as malignant transformation. We also sought to determine the effect of curcumin on the expression of these markers through immunohistochemistry.

    Methods: The expression of p53, TGF-β, and iNOS was evaluated through immunohistochemistry in 28 patients with OSMF before and after treatment with curcumin. Read More

    Versatility of nasolabial flaps for the management of severe trismus in oral submucous fibrosis.
    Indian J Dent Res 2016 Sep-Oct;27(5):492-497
    Director and Consultant, Balaji Dental and Craniofacial Hospital, Chennai, Tamil Nadu, India.
    Background: Oral submucous fibrosis (OSMF) is a chronic insidious disease affecting any part of the oral cavity and sometimes the pharynx. It is a collagen-related disorder predominantly associated with tobacco/areca nut chewing habit and characterized by progressive hyalinization of the submucosa. Prevalence of OSMF is 2. Read More

    Rebamipide to Manage Stomatopyrosis in Oral Submucous Fibrosis.
    J Contemp Dent Pract 2016 Dec 1;17(12):1009-1012. Epub 2016 Dec 1.
    Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal University, Mangaluru, Karnataka India.
    Introduction: Oral submucous fibrosis (OSF) causes progressive debilitating symptoms, such as oral burning sensation (stomatopyrosis) and limited mouth opening. The standard of care (SOC) protocol includes habit cessation, intralesional steroid and hyaluronidase injections, and mouth opening exercises. The objective of the study was to evaluate efficacy of rebamipide in alleviating burning sensation of the oral mucosa in OSF in comparison with SOC intralesional steroid injections. Read More

    Expression pattern of DKK3, dickkopf WNT signaling pathway inhibitor 3, in the malignant progression of oral submucous fibrosis.
    Oncol Rep 2017 Feb 8;37(2):979-985. Epub 2016 Dec 8.
    Department of Oral and Maxillofacial - Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China.
    Oral squamous cell carcinoma (OSCC) is a common malignant neoplasm of the head and neck. Oral submucous fibrosis (OSF) is one of its pre-cancerous lesions; however, the key molecular events in the tumorigenesis of OSF remain elusive. Dickkopf WNT signaling pathway inhibitor 3 (DKK3) is one of the Wnt antagonists, and its downregulation and methylation have been reported in multiple malignancies, while no report of its expression in the carcinogenesis of OSF exists. Read More

    Evaluation of Internal Echogenic Pattern of Masseter in Subjects with Myofascial Pain/ Myositis, Oral Submucous Fibrosis, Chewers, Bruxers and Healthy Individuals- A Preliminary Ultrasonographic Study.
    J Dent (Shiraz) 2016 Dec;17(4):361-366
    Dept. of Oral Medicine and Radiology, D.A. Pandu Memorial R. V. Dental College, Bengaluru, Ragiv Gandhi University of Health Sciences, India.
    Statement Of The Problem: The masseter is generally involved in myofascial pain, myositis, oral submucous fibrosis (OSMF), bruxism, and in subjects with habitual tobacco/arecanut chewing. In all the above conditions, changes in the internal echogenic pattern on ultrasonography of the muscle may be observed.

    Purpose: The present study aimed at evaluating the internal echogenic pattern of masseter by ultrasonography in subjects with various conditions affecting masster muscle. Read More

    Molecular Pathology of Malignant Transformation of Oral Submucous Fibrosis.
    J Environ Pathol Toxicol Oncol 2016 ;35(3):193-205
    Department of Oral Pathology, Dr. R. Ahmed Dental College and Hospital, Karnataka, India.
    Oral submucous fibrosis (OSF) is prevalent mostly in Southeast Asia, particularly in the Indian subcontinent. Chewing betel nuts and betel leaves, with or without tobacco, has been associated with OSF. Betel quid contents including guvacine, arecoline, guvacoline, arecaidine, and chavibetol are considered to play an important part in the occurrence of OSF. Read More

    Comparison of Therapeutic Efficacy of Placental Extract with Dexamethasone and Hyaluronic Acid with Dexamethasone for Oral Submucous Fibrosis - A Retrospective Analysis.
    J Clin Diagn Res 2016 Oct 1;10(10):ZC63-ZC66. Epub 2016 Oct 1.
    Reader, Department of Oral Medicine and Radiology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth , Vadodara, Gujarat, India .
    Introduction: Oral Submucous Fibrosis (OSMF) is a potentially malignant disease of the oral cavity associated with betel nut chewing. The management of OSMF has been a subject of controversy and no definitive and widely accepted treatment is currently available for this condition.

    Aim: To retrospectively evaluate the therapeutic efficacy of two treatment regimens (placental extract with dexamethasone and hyaluronic acid with dexamethasone) for the treatment of OSMF. Read More

    Efficacy and Safety of Intralesional Xantinol Nicotinate in the Treatment of Various Stages of Oral Submucous Fibrosis.
    J Clin Diagn Res 2016 Oct 1;10(10):ZC34-ZC37. Epub 2016 Oct 1.
    Senior Lecturer, Department of Oral Medicine and Radiology, Kothiwal Dental College and Research Centre , Moradabad, Uttar Pradesh, India .
    Introduction: Oral Submucous Fibrosis (OSMF) is one of the most prevalent potentially malignant disorders seen in South east population since ages. Despite the extensive amount of research held in this field, its treatment still remains a challenge. In this study, we present our experience in successfully managing OSMF with intralesional injections of a peripheral vasodilator namely xantinol nicotinate. Read More

    Effectiveness of Long Term Supervised and Assisted Physiotherapy in Postsurgery Oral Submucous Fibrosis Patients.
    Case Rep Dent 2016 3;2016:6081905. Epub 2016 Nov 3.
    Department of Oral and Maxillofacial Surgery, Sri Rajiv Gandhi College of Dental Sciences and Hospital, Bangalore, India.
    Oral submucous fibrosis is one of the leading potentially malignant disorders prevailing in India. A number of conservative and surgical treatment options have been suggested for this potentially malignant disorder (Arakeri and Brennan, 2013). While the role of physiotherapy has been highlighted in the conservative management, its importance in postsurgical cases to avoid scar contracture and subsequent relapse has not been given due importance in the literature. Read More

    Characterization of a Novel Dermal Fibrosis Model Induced by Areca Nut Extract that Mimics Oral Submucous Fibrosis.
    PLoS One 2016 16;11(11):e0166454. Epub 2016 Nov 16.
    School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China.
    Oral submucous fibrosis (OSF) is an oral potentially malignant disorder and areca quid chewing is the main etiological factor. However, the molecular mechanism underlying OSF remains unclear, partly due to the lack of an appropriate animal model. The present study aimed to establish and characterize an animal model of areca nut extract (ANE)-induced skin fibrosis that mimics OSF. Read More

    Immunohistochemical study of p21 and Bcl-2 in leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma.
    J Exp Ther Oncol 2016 Nov;11(4):285-292
    University of Taif, Faculty of Dentistry, Basic Dental Sciences, Taif, Kingdom of Saudi Arabia.
    Background: Oral Squamous cell carcinoma (OSCC) results from genetic damage, leading to uncontrolled cell proliferation of damaged cells and the cell death. In the course of its progression, visible changes are taking place at the cellular level (atypical) and the resultant at the tissue level (epithelial dysplasia).

    Objectives: The Aim of the present study was to evaluate and compare the expressions of intensity of p21 and Bcl-2 in Leukoplakia, oralsubmucous fibrosis (OSMF) and oral squamous cell carcinoma. Read More

    Aberrant SSEA-4 upregulation mediates myofibroblast activity to promote pre-cancerous oral submucous fibrosis.
    Sci Rep 2016 Nov 15;6:37004. Epub 2016 Nov 15.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
    Oral submucous fibrosis (OSF), regarded as a precancerous condition, is characterized by juxta-epithelial inflammatory reaction followed by fibro-elastic change in the lamina properia and epithelial atrophy. The pathologic mechanisms of OSF still need to be further clarified. In the study, we investigated the functional expression of SSEA-4, which is a well-known stemness marker, in myofibroblast activity and the clinical significance in OSF tissues. Read More

    Comparative evaluation of serum and salivary immunoglobulin G and A levels with total serum protein in oral submucous fibrosis patients: A case control study.
    J Pharm Bioallied Sci 2016 Oct;8(Suppl 1):S126-S132
    Department of Oral Medicine and Radiology, Karpaga Vinayaga Institute of Dental Sciences, Kanchipuram, Tamil Nadu, India.
    Aim And Objective: The objective of this study is to estimate and compare the serum and salivary immunoglobulin G and A (IgG, IgA) levels in various stages of oral submucous fibrosis (OSMF) patients and relate it to total serum protein (TSP) and hemoglobin (Hb) levels.

    Materials And Methods: The sample for the present study comprised a total of 20 healthy controls, 20 OSMF patients. About 5 ml of blood and 2 ml of saliva were collected. Read More

    High risk of malignant transformation of oral submucous fibrosis in Pakistani females: A potential national disaster.
    J Pak Med Assoc 2016 Nov;66(11):1362-1366
    Maxillo-Facial Surgery & Dean, Ochsner Clinic Foundation, Jefferson, LA, USA.
    Objective: To determine the relationship of age, gender and other associated risk factors linked with malignant transformation of oral submucous fibrosis into oral squamous cell carcinoma.

    Methods: This cross-sectional, multi-centre study was conducted at both public and private tertiary care hospitals and clinics of Karachi, Pakistan, from 2004 to 2012, and comprised patients with oral submucous fibrosis and/or oral squamous cell carcinoma. Out of the total sample, malignant transformations of oral submucous fibrosis to oral squamous cell carcinoma were included. Read More

    Limited mouth opening in oral submucous fibrosis: reasons, ramifications, and remedies.
    J Oral Pathol Med 2016 Oct 15. Epub 2016 Oct 15.
    Department of Oral Pathology, Manipal College of Dental Sciences, Manipal University, Manipal, India.
    Limited mouth opening (LMO) in oral submucous fibrosis (OSF) has been attributed to both the submucosal and muscle fibrosis (MF). While reflectory trismus was proposed before as an auxiliary mechanism by another group, the stretch-mediated muscle damage (MSD), histopathological changes in blood vessels (such as endothelial dysfunction, endothelial hypertrophy, and endarteritis obliterans), and upregulated anaerobic isoforms of lactate dehydrogenase (LDH) have been proposed by us as complementary events leading to MF. Additionally, the amount of hypoxia-mediated upregulation of anaerobic isoforms of LDH determines the extent of MF. Read More

    Assessment of Function of Eustachian Tube in Oral Submucous Fibrosis - A Tympanometric Study.
    J Clin Diagn Res 2016 Sep 1;10(9):ZC13-ZC15. Epub 2016 Sep 1.
    Professor and Head, Department of Oral Medicine, Diagnosis and Radiology, Sree Balaji Dental College and Hospital , Chennai, India .
    Introduction: Oral Submucous fibrosis (OSMF) is a chronic insidious disease of oral mucosa that occurs due to areca-nut chewing, consumption of chillies, autoimmunity and genetic predisposition. The disease starts with burning sensation and inability to tolerate spicy foods with gradual reduction in mouth opening due to fibrosis of the oral mucosa. The extension of fibrosis into the naso pharynx leads to reduction in hearing efficiency. Read More

    Expression of fibrosis-related molecules in the oral mucosa of six animal species: A reference for selecting animal models.
    Eur J Pharm Sci 2017 Jan 18;96:472-478. Epub 2016 Oct 18.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, People's Republic of China; Department of Oral Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, People's Republic of China. Electronic address:
    Several animal models have been used in studies associated with oral submucous fibrosis (OSF); however, an appropriate model based on the histopathological characteristics of OSF is still needed. This study aimed to provide histological references for selecting a potential model. The expression intensities of collagen type I (Col I), type III (Col III), type IV (Col IV), fibronectin (FN), transforming growth factors β (TGF-β), and connective tissue growth factor (CCN2) in the oral mucosa of the human and six non-human animal species were measured by immunohistochemistry. Read More

    A Study to Analyze Different Patterns of Quid Usage among Subjects with Oral Submucous Fibrosis in Mangalore Population.
    Adv Med 2016 29;2016:6124059. Epub 2016 Sep 29.
    A J Institute of Dental Sciences, Mangalore, India.
    Aim and Objectives. Oral submucous fibrosis (OSF) is a potentially malignant disorder associated with the usage of areca nut. Usage of processed forms of areca nut is popular among the youth and its carcinogenic effects are not well known. Read More

    Nanomechanical signatures of oral submucous fibrosis in sub-epithelial connective tissue.
    J Mech Behav Biomed Mater 2017 Jan 20;65:705-715. Epub 2016 Sep 20.
    School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India.
    Oral sub-mucous fibrosis (OSF), a potentially malignant disorder, exhibits extensive remodeling of extra-cellular matrix in the form of sub-epithelial fibrosis which is a possible sequel of assaults from different oral habit related irritants. It has been assumed that micro/nanobio-mechanical imbalance experienced in the oral mucosa due to fibrosis may be deterministic for malignant potential (7-13%) of this pathosis. Present study explores changes in mechanobiological attributes of sub-epithelial connective tissue of OSF and the normal counterpart. Read More

    Assessment of serum copper, iron and immune complexes in potentially malignant disorders and oral cancer.
    Braz Oral Res 2016 Oct 10;30(1):e101. Epub 2016 Oct 10.
    DayanandaSagar College of Dental Sciences, Department of Oral Medicine and Radiology, Karnataka, India.
    Potentially malignant disorders (PMDs) of oral cavity and oral cancer remain a cause of serious concern despite intensive research and development. Diet and immunity have been identified to play a crucial role as modifying factors in these diseases. Our study intended to explore this relationship by estimating and comparing the serum levels of copper, iron and circulating immune complexes (CICs) in patients diagnosed with PMDs and oral cancer and normal healthy individuals. Read More

    Screening of Oral Potentially Malignant Disorders Using Exfoliative Cytology: A Diagnostic Modality.
    J Cancer Epidemiol 2016 18;2016:8134832. Epub 2016 Sep 18.
    Department of Dentistry, Jawaharlal Nehru Medical College & Hospital, Kalyani, West Bengal 74123, India.
    Objective. Oral exfoliative cytology (OEC) has been implemented in the diagnosis of pathologic lesions for ages. The present study was undertaken to evaluate the cytomorphological features of some of the commonest potentially malignant disorders (leukoplakia, lichen planus, and oral submucous fibrosis) through a simple procedure and illustrate its importance in mass screening. Read More

    Expression of matrix metalloproteinase-9 in oral potentially malignant disorders: A systematic review.
    J Oral Maxillofac Pathol 2016 Sep-Dec;20(3):474-479
    Department of Oral Medicine and Radiology, Saveetha Dental College, Saveetha University, Chennai, Tamil Nadu, India.
    Matrix metalloproteinase-9 (MMP-9) is an inducible enzyme. Oral potentially malignant disorders (OPMDs) are considered as the early tissue changes that happen due to various habits such as smoking tobacco, chewing tobacco or stress. This alteration in the tissues alters the expression of MMP-9. Read More

    Caspase-3 expression in normal oral epithelium, oral submucous fibrosis and oral squamous cell carcinoma.
    J Oral Maxillofac Pathol 2016 Sep-Dec;20(3):445-452
    Division of Oral Medicine and Radiology, Rajah Muthiah Dental College and Hospital, Annamalai University, Chidambaram, Tamil Nadu, India.
    Context: The epithelium atrophy, as the oral submucous fibrosis (OSMF) progresses, is believed to be an after effect of stromal fibrosis, hyalinization, decrease in vascularity and cellularity and is considered as "ischemic atrophy." Due to hypoxia, caspase-3 get activation and subsequent decrease in viable cell count can occur.

    Aims And Objectives: To determine caspase-3 expression in various grades of OSMF and oral squamous cell carcinoma (OSCC) to find out whether upregulation of apoptosis is responsible for the epithelial changes in OSMF. Read More

    A randomized control trial measuring the effectiveness of a mouth-exercising device for mucosal burning in oral submucous fibrosis.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Dec 6;122(6):713-718. Epub 2016 Aug 6.
    Lecturer, Department of Orthodontics, Faculty of Dentistry, MAHSA University, Kuala Lumpur, Malaysia.
    Objectives: To evaluate effect of ice-cream stick exercise regimen with or without a mouth-exercising device (MED) on mucosal burning sensation in oral submucous fibrosis.

    Study Design: In total, 282 patients with oral submucous fibrosis were treated with topical corticosteroid and oral antioxidant and the ice-cream stick exercise regimen. Patients in subgroups A1, A2, and A3 were additionally given a new MED. Read More

    "A randomized double-blind, multiple-arm trial comparing the efficacy of submucosal injections of hyaluronidase, dexamethasone, and combination of dexamethasone and hyaluronidase in the management of oral submucous fibrosis"-a commentary.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Dec 31;122(6):784. Epub 2016 Aug 31.
    Assistant Professor, Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, India.

    Clinicobiochemical evaluation of turmeric with black pepper and nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Dec 6;122(6):705-712. Epub 2016 Aug 6.
    Department of Oral Medicine and Radiology, Seema Dental College, Rishikesh, Uttrakhand, India.
    Objective: To investigate the effectiveness of turmeric with black pepper and nigella sativa in oral submucous fibrosis (OSMF).

    Study Design: Forty OSMF patients were randomly divided into two groups. The study was performed under a double-blind, randomized design. Read More

    [Expression of secreted frizzled-related protein-1 in patient with oral submucous fibrosis].
    Zhonghua Kou Qiang Yi Xue Za Zhi 2016 Oct;51(10):616-622
    Department of Oral Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
    Objective: To investigate the concentrations and clinical significance of secreted frizzled-related protein-1(SFRP1) insaliva and gingival crevicular fluid of patients with oral submucous fibrosis (OSF) as well as the expression of SFRP1 in patients' OSF buccal mucosa. Methods: Twenty OSF patients aged 20 to 40 years old were recruited and randomly divided into two experimental groups, of which were triamcinolone acetonide group and combined triamcinolone acetonide and salvia miltiorrhiza group, respectively. Ten healthy volunteers matchable in sex and age with the patients were recruited as control group. Read More

    Role of areca nut induced JNK/ATF2/Jun axis in the activation of TGF-β pathway in precancerous Oral Submucous Fibrosis.
    Sci Rep 2016 Oct 6;6:34314. Epub 2016 Oct 6.
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore- 560012, India.
    Oral submucous fibrosis (OSF) is potentially premalignant with progressive and irreversible extracellular matrix deposition accompanied by epithelial atrophy and like other fibrotic disorders, is primarily a TGF-β driven disease. OSF is caused by prolonged chewing of areca nut. Our previous studies reported a pivotal role for TGF-β activation and its effects contributing to OSF. Read More

    Immediate versus delayed aggressive physical therapy following buccal fat pad interposition in oral submucous fibrosis-a prospective study in Central India.
    Oral Maxillofac Surg 2016 Dec 28;20(4):397-403. Epub 2016 Sep 28.
    Swargiya Dadasaheb Kalmegh Smruti Dental College And Hospital, Nagpur, India.
    Purpose: Oral submucous fibrosis is a disease of an Indian subcontinent with obscure aetiology and poorly treated with varying signs and symptoms. OSMF occurs at any age but is most commonly seen in teenagers and adults in the age ranging between 16 and 35 years. A number of surgical treatments have been used for the treatment of oral submucous fibrosis with unpredictable results. Read More

    Surgical defect coverage in oral submucous fibrosis patients with single-stage extended nasolabial flap.
    Oral Maxillofac Surg 2016 Dec 24;20(4):411-415. Epub 2016 Sep 24.
    Department of Oral and Maxillofacial Surgery Government College of Dentistry, Indore, India.
    Purpose: Long standing oral submucous fibrosis (OSMF) is associated with involvement of the oral submucosa and the muscles of mastication leading to difficulty in mouth opening. Various surgical modalities are mentioned for release but each has its own limitations. The aim of the study was to evaluate the postoperative mouth opening in patients of OSMF after excision of fibrous bands followed by coronoidotomy and surgical defect coverage by extended nasolabial flap. Read More

    Clinical Effectiveness of Aloe Vera in the Management of Oral Mucosal Diseases- A Systematic Review.
    J Clin Diagn Res 2016 Aug 1;10(8):ZE01-7. Epub 2016 Aug 1.
    Senior Lecturer, Department of Preventive and community Dentistry, New Horizon Dental College and Research Institute , Sakri, Bilaspur, India .
    Introduction: Aloe vera is well known for its medicinal properties which lead to its application in treating various diseases. Its use in treating oral lesions has not been much documented in literature.

    Aim: Although, systematic reviews on aloe vera and its extracts have been done earlier, but in relation to oral diseases this is the first systematic review. Read More

    Penile Circular Fasciocutaneous (McAninch) Flap as an Option for Complex Anterior Urethral Stricture in Case of Non-Viable Buccal Mucosal Graft.
    J Clin Diagn Res 2016 Jul 1;10(7):PD09-11. Epub 2016 Jul 1.
    Assistant Professor, Department of Urology, Institute of Nephro Urology , Bangalore, Karnataka, India .
    The penile circular fasciocutaneous flap (FCF) is employed in the successful single stage reconstruction of long segment complex anterior urethral strictures especially when buccal mucosa is unavailable due to various reasons. A 65-year-old gentleman, chronic smoker and tobacco chewer, hypertensive on treatment, presented with obstructive lower urinary tract symptoms for 8 months. He had no prior urethral catheterization. Read More

    Bipaddled anterolateral thigh perforator flap for simultaneous reconstruction of bilateral buccal defects following oral cancer ablation or release of oral submucous fibrosis.
    J Surg Case Rep 2016 Sep 12;2016(9). Epub 2016 Sep 12.
    Department of Plastic and Reconstructive Surgery, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, Taiwan
    It is a challenge to simultaneously reconstruct bilateral buccal defects following oral cancer ablation or release of oral submucous fibrosis. In this study, we report two cases where bipaddled anterolateral thigh perforator flaps were used to resurface two separate buccal defects. Read More

    Estimation of major immunoglobulins in smokers and gutkha chewers.
    J Oral Maxillofac Pathol 2016 May-Aug;20(2):219-23
    Department of Oral and Maxillofacial Pathology, Government Dental College and Hospital, Ahmedabad, Gujarat, India.
    Aim: To estimate the level of IgG and IgA major immunoglobulins in patients having the habit of smoking, gutkha chewing and in patients without any tobacco habit as control.

    Materials And Methods: Estimation of major immunoglobulins IgG and IgA was carried out by automated Nephelometry method in ten patients (control group), forty patients who had habit of smoking either bidi or cigarette and forty patients who had the habit of gutkha chewing. Among forty patients who smoked, twenty patients were without any lesion while twenty patients had homogenous leukoplakia. Read More

    Expression of MUC1 mucin in potentially malignant disorders, oral squamous cell carcinoma and normal oral mucosa: An immunohistochemical study.
    J Oral Maxillofac Pathol 2016 May-Aug;20(2):214-8
    Department of Oral Pathology and Microbiology, Vydehi Institute of Dental Sciences and Research Centre, Bengaluru, Karnataka, India.
    Background: Mucins alteration in glycosylation is associated with the development and progression of malignant diseases. Therefore, mucins are used as valuable markers to distinguish normal and disease conditions. Many studies on MUC1 expression have been conducted on variety of neoplastic lesions other than head and neck region. Read More

    Dental Informatics tool "SOFPRO" for the study of oral submucous fibrosis.
    J Oral Maxillofac Pathol 2016 May-Aug;20(2):194-201
    Department of Oral Pathology, Government Dental College and Hospital, Medical College Campus, Medical Square, Nagpur, Maharashtra, India.
    Background: Dental informatics is an evolving branch widely used in dental education and practice. Numerous applications that support clinical care, education and research have been developed. However, very few such applications are developed and utilized in the epidemiological studies of oral submucous fibrosis (OSF) which is affecting a significant population of Asian countries. Read More

    Expression deregulation of mir31 and CXCL12 in two types of oral precancers and cancer: importance in progression of precancer and cancer.
    Sci Rep 2016 Sep 6;6:32735. Epub 2016 Sep 6.
    Human Genetics Unit, Indian Statistical Institute, Kolkata, India.
    Oral cancer generally progresses from precancerous lesions such as leukoplakia (LK), lichen planus (LP) and oral submucous fibrosis (OSMF). Since few of these precancers progress to cancers; it is worth to identify biological molecules that may play important roles in progression. Here, expression deregulation of 7 miRNAs (mir204, mir31, mir31*, mir133a, mir7, mir206 and mir1293) and their possible target genes in 23 cancers, 18 LK, 12 LP, 23 OSMF tissues compared to 20 healthy tissues was determined by qPCR method. Read More

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