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    1186 results match your criteria Oral Submucous Fibrosis

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    Hinokitiol ablates myofibroblast activation in precancerous oral submucous fibrosis by targeting Snail.
    Environ Toxicol 2018 Jan 12. Epub 2018 Jan 12.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
    Oral submucous fibrosis (OSF) is a precancerous condition with symptoms of limited mouth opening and areca nut chewing habit has been implicated in its pathogenesis. Hinokitiol, a natural tropolone derived from Chamacyparis taiwanensis, has been reported to improve oral lichen planus and inhibit various cancer cells. Here, we showed that hinokitiol reduced the myofibroblast activities in fBMFs and prevented the arecoline-induced transdifferentiation. Read More

    Immunohistochemical Expression Of Ezrin In Oral Potentially Malignant Disorders-A Descriptive Study.
    J Pharm Bioallied Sci 2017 Nov;9(Suppl 1):S205-S210
    Department of Oral Pathology and Microbiology, Saveetha Dental College, Saveetha University, Chennai, Tamil Nadu, India.
    Introduction: Ezrin, also known as cytovillin, is a member of the ERM family of protein. Ezrin cross-links actin filament with the plasma membrane. They are involved in the formation of microvilli, cell-cell adhesion, maintenance of cell shape, cell motility, and membrane trafficking. Read More

    Comparative Evaluation of Serum Lipid Profile in Patients with Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma with that of Control Subjects: A Case Control Study.
    J Pharm Bioallied Sci 2017 Nov;9(Suppl 1):S191-S196
    Department of Conservative Dentistry and Endodontics, Vinayaka Missions Sankarachariyar Dental College, Salem, Tamil Nadu, India.
    Aim: The aim of the study was to evaluate the serum lipid profile among untreated oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSMF) patients.

    Materials And Methods: This study was done in three groups of patients - OSMF, OSCC, and control. There are twenty participants in each group. Read More

    Prevalence of Oral Mucosal Lesions among Dental Patients with Mixed Habits in Salem District - A Study.
    J Pharm Bioallied Sci 2017 Nov;9(Suppl 1):S55-S67
    Department of Oral Medicine, Vinayaka Missions Sankarachariyar Dental College, Salem, Tamil Nadu, India.
    Background: The practice of betel nut chewing with or without tobacco is still practiced in south india, salem inspite of its harmful effects.

    Methodology: 200 Patients visiting the outpatient department, Oral medicine and radiology from Aug 2015 to Aug 2016.

    Result And Conclusion: In our study, 3 women were exclusively churut smokers. Read More

    Development of a mouse model of arecoline-induced oral mucosal fibrosis.
    Asian Pac J Trop Med 2017 Dec 29;10(12):1177-1184. Epub 2017 Oct 29.
    Department of Oral Medicine, Haikou City People's Hospital, Haikou 570100, China.
    Objective: To develop a BALB/c mouse model of oral submucous fibrosis (OSF) induced by arecoline and to exhibit an accumulation of collagen and angiogenesis changes.

    Methods: BALB/c mice were randomly assigned to either the control (distilled water) or experimental group (arecoline) (n = 40). Eight mice from each group were sacrificed every 4 weeks since 8 weeks post treatment. Read More

    Velar morphological variants in oral submucous fibrosis: A comparative digital cephalometric study.
    Indian J Dent Res 2017 Nov-Dec;28(6):623-628
    Department of Oral Medicine and Radiology, Al-Badar Rural Dental College and Hospital, Gulbarga, Karnataka, India.
    Context: Soft palate (velar) plays a significant role in various important functions in the head and neck region. Its diverse morphology is implicated in a variety of diseases. Knowledge about the varied morphological pattern of soft palate in oral submucous fibrosis (OSMF) patients can give us a clear understanding about disease progress in the oropharyngeal region for a proper diagnosis and also help the maxillofacial surgeon in successful structural and functional corrections associated with this disorder. Read More

    LncRNA GAS5-AS1 inhibits myofibroblasts activities in oral submucous fibrosis.
    J Formos Med Assoc 2017 Dec 14. Epub 2017 Dec 14.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address:
    Background/purpose: Emerging research findings suggest that long non-coding RNAs (lncRNAs) are key regulators to fibrosis formation. Nevertheless, the role of lncRNA GAS5-AS1 in the progression of precancerous oral submucous fibrosis (OSF) remains to be elucidated.

    Methods: Quantitative real-time PCR were used to examine the expression of GAS5-AS1 in OSF tissues. Read More

    Thioctic acid in oral submucous fibrosis (India's disease) - A better tomorrow.
    J Stomatol Oral Maxillofac Surg 2017 Dec 12. Epub 2017 Dec 12.
    Department of oral medicine and radiology, A. J. Institute of Dental Sciences, Mangalore, India. Electronic address:
    Oral submucous fibrosis (OSMF), because of its common occurrence in Indian population is known as India's disease. Regardless of diagnostic and therapeutic developments, oral potentially malignant disorders (PMD) and cancers are disseminating at a distressing rate. There is this prerequisite for unrelenting determination to find out apt treatment options so that malignant transformation may be prevented and more so the prevailing morbidity and mortality. Read More

    A Comparative Clinical Evaluation of the Buccal Fat Pad and Extended Nasolabial Flap in the Reconstruction of the Surgical Defect in Oral Submucous Fibrosis Patients.
    J Oral Maxillofac Surg 2017 Nov 21. Epub 2017 Nov 21.
    Self-employed, Department of Oral and Maxillofacial Surgery, Government College of Dentistry, Indore, India.
    Purpose: The aim of this study was to compare the efficacy of locally available nasolabial and buccal fat pad flaps for increasing postoperative mouth opening in the reconstruction of the defect created after fiberotomy in surgically treated cases of oral submucous fibrosis (OSMF).

    Materials And Methods: Of 32 patients selected for the study, 21 patients underwent closure of the surgical defect using the buccal fat pad (group 1) and 11 patients underwent closure of the surgical defect using a nasolabial flap (group 2). Histologically proven cases of OSMF with a mouth opening no larger than 25 mm were included in the study. Read More

    STRO-1 confers myofibroblast transdifferentiation in fibroblasts derived from oral submucous fibrosis.
    J Oral Pathol Med 2017 Dec 6. Epub 2017 Dec 6.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
    Background: STRO-1 is a mesenchymal cell marker present on all clonogenic stromal precursors. Current evidence has indicated that the pathogenesis of fibrotic changes may be mediated by stemness properties. The aim of this study was to investigate the role of STRO-1 in areca quid chewing-associated oral submucous fibrosis (OSF). Read More

    Micronucleus Assay: An Early Diagnostic Tool to Assess Genotoxic Changes in Patients with Tobacco Use, Oral Leukoplakia and Oral Submucous Fibrosis.
    J Clin Diagn Res 2017 Sep 1;11(9):ZC28-ZC32. Epub 2017 Sep 1.
    Medical Research Scientist, Jorhat Medical College and Hospital, Barbheta, Jorhat, Assam, India.
    Introduction: Micronuclei (MNi) are acentric chromatid or chromosome fragments produced via genetic damage through genotoxic agents contained in tobacco and betel nut. Evidently, the various Oral Potentially Malignant Disorders (OPMDs) like oral lichen Planus, oral leukoplakia and Oral Submucous Fibrosis (OSMF) demonstrate MNi, as a substantiation of genetic damage. As these changes can be easily appreciated in oral exfoliated cells, an exfoliated cell based MNi assay might be utilized as handy and non invasive biomonitoring tool for gauging the genetic damage and hence the propensity for malignant transformation in OPMDs. Read More

    Status of Serum and Salivary Ascorbic Acid in Oral Potentially Malignant Disorders and Oral Cancer.
    Indian J Med Paediatr Oncol 2017 Jul-Sep;38(3):306-310
    Department of Oral Medicine and Radiology, A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, Karnataka, India.
    Background And Aims: The aim of this study was to estimate the detoxification status of serum and saliva by assessing the serum and salivary Vitamin C in oral potentially malignant disorders and oral cancer.

    Subjects And Methods: A total of 90 subjects, 30 subjects with oral potentially malignant disorders, 30 subjects with oral cancer, and 30 healthy subjects (controls) were included in the study. Serum and saliva were collected and levels of Vitamin C were assessed. Read More

    Utility of superiorly based platysma myocutaneous flap for reconstruction of intraoral surgical defects: our experience.
    Oral Maxillofac Surg 2017 Nov 23. Epub 2017 Nov 23.
    Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Nagpur, 440024, India.
    Purpose: Various surgical modalities have been advocated for the soft tissue reconstruction of oral cavity with variable results. This prospective study evaluates the utility of platysma myocutaneous flap (PMF) in the reconstruction of surgical defects followed by treatment of oral submucous fibrosis (OSMF) and oral squamous cell carcinoma (OSCC) in terms of healing and functional outcomes.

    Methods: In this prospective study, 47 patients with OSMF and 15 of OSCC were evaluated and selected for PMF reconstruction. Read More

    Oral submucous fibrosis: an etiological dilemma.
    J Exp Ther Oncol 2017 Nov;12(2):163-166
    Private practitioner, Indore. Madhya Pradesh, India.
    Objective: Oral Submucous Fibrosis (OSF), is a well-recognized, oral potentially malignant disorder predominantly affecting the South- Asian countries. OSF causes unique generalized fibrosis of the submucosal oral soft tissues, resulting in marked rigidity of the oral mucosa leading to progressive inability to open the mouth, rigidity of lips and difficulty in protruding the tongue. In this review we have discussed the multifactorial etiology of this potentially malignant disorder, including Chillies, Nutritional Deficiencies, Inducible nitric oxide synthsis (iNOS), genetic and immunological predisposition; and most importantly the role of areca nut and the effect of copper content in it. Read More

    Raman exfoliative cytology for oral precancer diagnosis.
    J Biomed Opt 2017 Nov;22(11):1-12
    Tata Memorial Center, Advanced Center for Treatment, Research and Education in Cancer, Chilakapati L, India.
    Oral premalignant lesions (OPLs) such as leukoplakia, erythroplakia, and oral submucous fibrosis, often precede oral cancer. Screening and management of these premalignant conditions can improve prognosis. Raman spectroscopy has previously demonstrated potential in the diagnosis of oral premalignant conditions (in vivo), detected viral infection, and identified cancer in both oral and cervical exfoliated cells (ex vivo). Read More

    Glabridin inhibits the activation of myofibroblasts in human fibrotic buccal mucosal fibroblasts through TGF-β/smad signaling.
    Environ Toxicol 2018 Feb 9;33(2):248-255. Epub 2017 Nov 9.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
    Oral submucous fibrosis (OSF) has been recognized as one of the oral potentially malignant disorders. Areca nut chewing is implicated in this pathological fibrosis, and it causes chronic inflammation and persistent activation of myofibroblasts. As yet, existing treatments only provide temporary symptomatic relief and there is a lack of an effective intervention to cure OSF. Read More

    Expression of β1integrin in normal epithelium, oral submucous fibrosis and oral squamous cell carcinoma.
    Pathol Res Pract 2017 Oct 26. Epub 2017 Oct 26.
    Department of Oral and Maxillofacial Pathology, Rajah Muthaih Dental College and Hospital, Annamalai University, Annamalai Nagar, Chidhambaram, Tamil Nadu, India. Electronic address:
    Introduction And Aims: The possible reason suggested for epithelial atrophy in oral submucous fibrosis (OSMF) is ischemia. Dysregulation in the epithelial proliferation and maturation is also thought to be a cause. The β1 integrin identifies the oral epithelial stem cells. Read More

    Evaluation of myofibroblasts in oral submucous fibrosis and oral squamous cell carcinoma: The pathogenesis and correlation.
    Dent Res J (Isfahan) 2017 Sep-Oct;14(5):314-320
    Department of Oral Pathology, Kanti Devi Dental College, Mathura, Uttar Pradesh, India.
    Background: Oral submucous fibrosis (OSMF) is a chronic debilitating disease of the oral cavity having premalignant potential and unclear pathogenesis. Recently, myofibroblast has been postulated to play an important role in its pathogenesis and in the process of carcinogenesis. The purpose of this study was to evaluate and compare the presence of myofibroblasts in normal mucosa, different grades of OSMF, and oral squamous cell carcinoma (OSCC). Read More

    PTMA, a new identified autoantigen for oral submucous fibrosis, regulates oral submucous fibroblast proliferation and extracellular matrix.
    Oncotarget 2017 Sep 24;8(43):74806-74819. Epub 2017 Aug 24.
    Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha 410078, China.
    Oral submucous fibrosis (OSF) is a chronic, insidious disease. The presence of autoantibodies in sera of OSF patients is the most characteristic and direct evidence of OSF being an autoimmune disease. To identify the specific autoantigens which could contribute to antibody production, the Human Proteome Microarrays composed of 19000 full-length unique proteins were employed. Read More

    Correlation of ultrasonographic measurements, histopathological grading, and clinical staging in oral submucous fibrosis.
    Indian J Dent Res 2017 Sep-Oct;28(5):476-481
    Department of Oral Medicine and Radiology, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, Maharashtra, India.
    Aims And Objectives: To evaluate the presence and thickness of submucosal fibrosis in oral submucous fibrosis (OSMF) patients ultrasonographically and to correlate these findings with the clinical stage and histological grade of OSMF.

    Materials And Methods: Forty participants (twenty cases and twenty controls) were included in the study. The patients diagnosed clinically as having OSMF and consented for biopsy were included in the cases, and completely healthy individuals with no habit history or oral lesions were included in the control group after matching the body mass index. Read More

    The role of halofuginone in fibrosis: more to be explored?
    J Leukoc Biol 2017 Dec 6;102(6):1333-1345. Epub 2017 Oct 6.
    Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China; and
    Fibrosis, which can be defined as an abnormal or excessive accumulation of extracellular matrix (ECM), particularly fibrillar collagens, is a key driver of progressive organ dysfunction in many inflammatory and metabolic diseases, including idiopathic pulmonary fibrosis (IPF), cirrhosis, nephropathy, and oral submucous fibrosis (OSF). It has been estimated to contribute to ∼45% of deaths in the developed world. Therefore, agents that target specific fibrotic pathways, with the consequence of slowing, arresting, or even reversing the progression of tissue fibrogenesis, are urgently needed. Read More

    Inhibitory effect of GMI, an immunomodulatory protein from Ganoderma microsporum, on myofibroblast activity and proinflammatory cytokines in human fibrotic buccal mucosal fibroblasts.
    Environ Toxicol 2018 Jan 6;33(1):32-40. Epub 2017 Oct 6.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
    Oral submucous fibrosis (OSF) has been indicated as one of the oral potentially malignant disorders. Epidemiological studies have attributed this pathological fibrosis to the habit of areca nuts chewing, which causes chronic inflammation and persistent activation of myofibroblasts in the oral cavity. Hence, it is crucial to find an effective intervention to ameliorate inflammation in order to prevent the malignant progression of OSF. Read More

    Identification of over expressed proteins in Oral Submucous Fibrosis by proteomic analysis.
    J Cell Biochem 2017 Oct 5. Epub 2017 Oct 5.
    Molecular Genetics Division, CSIR- Indian Institute of Chemical Biology, Kolkata-700 032, India.
    Early detection and identification of oral pre-malignancy or malignancy help in management of the disease and improve survival rates. Oral submucous fibrosis (OSMF) is a major threat to public health worldwide and especially in Southeast Asian countries. Identification of biomarkers is a necessary step towards early diagnosis and treatment. Read More

    Bilateral Submental Flap: An Innovative Modification.
    J Craniofac Surg 2017 Nov;28(8):e786-e788
    Maharashtra, India.
    Early management of premalignant lesions like oral submucous fibrosis cannot be underestimated in context of prevention and control of oral malignancies. Soft tissue reconstruction of the oral cavity and face is a complex undertaking. Several flaps local and distant as well as microvascular are available, each with their pros and cons. Read More

    Assessment of anxiety, depression, and serum cortisol level in oral submucous fibrosis patients: A controlled clinical trial.
    Eur J Dent 2017 Jul-Sep;11(3):293-298
    Department of Oral Medicine and Radiology, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, India.
    Objective: The aim of this study was to assess the anxiety, depression, and serum cortisol level in OSMF patients.

    Materials And Methods: This cross-sectional study was conducted in the Outpatient Department of Oral Medicine and Radiology, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India. Age- and gender-matched 105 patients were divided into three equal groups as follows: Group 1 - those with areca nut chewing habits and OSMF, Group 2 - those with areca nut chewing habits but no OSMF, and Group 3- those without areca nut chewing habits and without OSMF. Read More

    Validation of immunoexpression of tenascin-C in oral precancerous and cancerous tissues using ImageJ analysis with novel immunohistochemistry profiler plugin: An immunohistochemical quantitative analysis.
    J Oral Maxillofac Pathol 2017 May-Aug;21(2):211-217
    Department of Oral Pathology and Microbiology, KLE University, KLE VK Institute of Dental Sciences, Belgaum, Karnataka, India.
    Background: Immunohistochemistry (IHC) is a molecular technique that has grown tremendously over the years. However, the assessment is only qualitative which is subjective and causes errors. Due to this limitation, several excellent markers have not gained importance and reached clinical trials. Read More

    Prosthetic rehabilitation of oral submucous fibrosis patients: A systematic review of published case reports and case series.
    PLoS One 2017 6;12(9):e0184041. Epub 2017 Sep 6.
    Department of Prosthodontics & Dental Materials and Dean, School of Dental Medicine, University of Siena, Italy.
    Background: Oral submucous fibrosis (OSF) is an insidious chronic condition characterized by restricted mouth opening. Prosthetic rehabilitation is challenging for OSF patients as obtaining a good impression requires adequate mouth opening. The aim of the present review is to systematically present the data from case reports published in the English-language literature. Read More

    An update on studies on etiological factors, disease progression, and malignant transformation in oral submucous fibrosis.
    J Cancer Res Ther 2017 Jul-Sep;13(3):399-405
    Department of Oral and Maxillofacial Pathology, Pacific Dental College and Hospital, Udaipur, Rajasthan, India.
    Worldwide estimates of oral submucous fibrosis (OSMF) show a confinement to Indians and Southeast Asians. In India, the prevalence of OSMF has increased over the past four decades from 0.03% to 6. Read More

    Effect of Frequency and Duration of Tobacco Use on Oral Mucosal Lesions – A Cross-Sectional Study among Tobacco Users in Hyderabad, India
    Asian Pac J Cancer Prev 2017 08 27;18(8):2233-2238. Epub 2017 Aug 27.
    Purpose: Tobacco use is one of the most important risk factors for the development of oral mucosal lesions including oral pre-cancer and cancer. The type and location of the lesion varies with the type of tobacco used, the way it is used, and the frequency and duration of use. Hence, the present study aimed to determine the effect of frequency and duration of tobacco use on oral mucosal lesions among tobacco users in Hyderabad city. Read More

    Total Serum Protein Estimation and Its Correlation with Clinical and Histopathological Grading using Masson's Trichrome Stain in Patients of Oral Submucous Fibrosis.
    Contemp Clin Dent 2017 Apr-Jun;8(2):286-292
    Department of Oral and Maxillofacial Pathology and Microbiology, D.Y. Patil University, School of Dentistry, Nerul, Navi Mumbai, Maharashtra, India.
    Objectives: Oral submucous fibrosis (OSMF) caused by dense deposition of collagen fibers which is a protein. There is a plethora of research to evaluate degree of collagen deposition using various simple histochemical techniques, but its correlation with total serum protein (TSP) level has not been explored so far.

    Materials And Methods: This case-control study comprised total forty samples with thirty cases of OSMF and ten cases were selected as control group, divided into four groups as per Lai et al. Read More

    Evaluation of Oral Pentoxifylline in the Management of Oral Submucous Fibrosis - An Ultrasonographic Study.
    Contemp Clin Dent 2017 Apr-Jun;8(2):200-204
    Department of Oral Medicine and Radiology, Tamil Nadu Government Dental College and Hospital, Chennai, Tamil Nadu, India.
    Aim And Objective: To evaluate the therapeutic efficacy of oral pentoxifylline in the treatment of oral submucous fibrosis (OSMF) patients by assessing the clinical symptoms such as burning sensation, mouth opening, and submucosal layer thickness and echogenicity using ultrasonography, both pre- and post-operatively.

    Materials And Methods: Thirty study subjects were included in the study and divided into two groups in single-blind randomized manner, oral pentoxifylline and dexamethasone group. Burning sensation, mouth opening, ultrasonographic submucosal thickness, and echogenicity were recorded both pre- and post-operatively. Read More

    Cyclophilin A was revealed as a candidate marker for human oral submucous fibrosis by proteomic analysis.
    Cancer Biomark 2017 Sep;20(3):345-356
    State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China.
    Oral submucous fibrosis (OSF) is a chronic insidious disease which predisposes to oral cancer. Understanding the molecular markers for OSF is critical for diagnosis and treatment of oral cancer. In this study, the proteins expression profile of OSF tissues was compared to normal mucous tissues by 2 dimensional electrophoresis (2-DE). Read More

    Serum-based diagnostic prediction of oral submucous fibrosis using FTIR spectrometry.
    Spectrochim Acta A Mol Biomol Spectrosc 2018 Jan 8;189:322-329. Epub 2017 Aug 8.
    School of Medical Science & Technology, Indian Institute of Technology, Kharagpur, India. Electronic address:
    Oral submucous fibrosis (OSF) is found to have the highest malignant potentiality among all other pre-cancerous lesions. However, its detection prior to tissue biopsy can be challenging in clinics. Moreover, biopsy examination is invasive and painful. Read More

    Identification of α-enolase as a prognostic and diagnostic precancer biomarker in oral submucous fibrosis.
    J Clin Pathol 2017 Aug 18. Epub 2017 Aug 18.
    School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, India.
    Aims: Diagnostic ambiguities regarding the malignant potentiality of oral submucous fibrosis (OSF), an oral precancerous condition having dysplastic and non-dysplastic isoforms are the major failure for early intervention of oral squamous cell carcinoma (OSCC) patients. Our goal is to identify proteomic signatures from biopsies that can be used as precancer diagnostic marker for patient suffering from OSF.

    Methods: The high throughput techniques adopting de novo peptide sequencing (1D SDS-PAGE coupled nanoLC MALDI tandem mass spectrometry (MS/MS)-based peptide mass fingerprint), immunohistochemistry (IHC), Western blot (WB) and real-time PCR (RT-PCR) analysis are considered for such biomarker identification and multilevel validations. Read More

    Tobacco Abuse and Associated Oral Lesions among Interstate Migrant Construction Workers.
    J Contemp Dent Pract 2017 Aug 1;18(8):695-699. Epub 2017 Aug 1.
    Department of Oral Pathology and Microbiology, Kannur Dental College, Kannur, Kerala, India.
    Aim: The present study was conducted to assess the prevalence of tobacco use and associated oral mucosal lesions among construction workers of Cochin, Kerala, India.

    Materials And Methods: A cross-sectional study was carried at various construction sites of Cochin and 2,163 workers were selected using multistage sampling method and were interviewed and examined. Information regarding demographic details, form, type, frequency of tobacco use, earlier attempt to quit, and willingness to quit tobacco use was obtained using predesigned questionnaire. Read More

    [Expression of PTPRZ1 in oral squamous cell carcinoma originated from oral submucous fibrosis and its clinical significance].
    Shanghai Kou Qiang Yi Xue 2017 Apr;26(2):198-203
    Department of Oral and Maxillofacial Surgery, Affiliated Haikou Hospital of Xiangya Medical College. Haikou 570208, Hainan Province, China.
    Purpose: This study was aimed to detect the expression of PTPRZ1 in oral squamous cell carcinoma (OSCC) originated from oral submucous fibrosis (OSF), and discuss its role in the development and progression of OSCC originating from OSF as well as its clinical significance.

    Methods: Immunohistochemisty (IHC) and Western blot (WB) for the expression and distribution of PTPRZ1 were carried out in 36 cases of OSF transforming into OSCC, 23 cases of OSCC and 21 cases of healthy controls. The data were analyzed by Chi-square test using SPSS 21. Read More

    [Methods and effects of injection of salvianolic acid B combined with triamcinolone acetonide in the treatment of oral submucous fibrosis].
    Shanghai Kou Qiang Yi Xue 2017 Apr;26(2):188-192
    Department of Oncology, the Third Xiangya Hospital, Central South University. Changsha 410013, Hunan Province, China.
    Purpose: To introduce the methods of triamcinolone acetonide (TA) and salvianolic acid B(SA-B) intralesional injection in the treatment of oral submucous fibrosis and evaluate the treatment effects.

    Methods: TA combined with SA-B were consecutively applied intralesionally 1 time weekly for 30 times. The technique of intralesional injection was that syringe needle be emptied into submucous tissues 1 cm posterior to the corner of oral cavity running from the front to retromolar area by pushing the injection, then the syringe needle retained to the original point and upward from the front to retromolar area by pushing the injection, finally the syringe needle returned to the starting point and downward from the front to retromolar area by pushing the injection. Read More

    Textural pattern classification for oral squamous cell carcinoma.
    J Microsc 2018 Jan 2;269(1):85-93. Epub 2017 Aug 2.
    Dr. B. Borooah Cancer Research Institute, Guwahati, Assam, India.
    Despite being an area of cancer with highest worldwide incidence, oral cancer yet remains to be widely researched. Studies on computer-aided analysis of pathological slides of oral cancer contribute a lot to the diagnosis and treatment of the disease. Some researches in this direction have been carried out on oral submucous fibrosis. Read More

    Impact of oral potentially malignant disorders on quality of life.
    J Oral Pathol Med 2017 Aug 2. Epub 2017 Aug 2.
    Menzies Health Institute Queensland and School of Dentistry and Oral Health, Griffith University, Qld, Australia.
    Background: Oral potentially malignant disorders (OPMDs) could have a significant psychological impact on patients, principally because of the unknown risk of malignant transformation, while the physical and functional impairments could differ. This study aimed to assess the impact of three different OPMDs and their disease stages on the quality of life (QoL) of affected patients.

    Methods: Oral leukoplakia (OL), oral lichen planus (OLP) and oral submucous fibrosis (OSF) patients who were undergoing treatment at an oral medicine clinic of a dental teaching hospital in India were the study population. Read More

    Efficacy of oral colchicine with intralesional hyaluronidase or triamcinolone acetonide in the Grade II oral submucous fibrosis.
    Natl J Maxillofac Surg 2017 Jan-Jun;8(1):50-54
    Department of Oral and Maxillofacial Surgery, King George's Medical University, Lucknow, Uttar Pradesh, India.
    Background And Objectives: Oral submucous fibrosis (OSMF) is a potentially malignant disorder of oral mucosa affecting mainly population in South and Southeast Asia. The aim of this study is to compare the effectiveness of oral colchicine with intralesional injection of hyaluronidase or injection triamcinolone acetonide in patients with Grade II OSMF.

    Materials And Methods: The study included thirty patients of clinically diagnosed Grade II OSMF. Read More

    Evaluating the efficacy of pentoxifylline in the treatment of oral submucous fibrosis: A meta-analysis.
    Oral Dis 2017 Jul 24. Epub 2017 Jul 24.
    State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
    Oral submucous fibrosis (OSMF), a potentially malignant oral cavity disorder that causes speech and mastication problems, lacks an established treatment regimen; moreover, no treatment can effectively reverse the course of OSMF. A meta-analysis was conducted to investigate the efficacy of the peripheral vasodilator, pentoxifylline, in the treatment of OSMF. We searched five different databases for studies meeting our eligibility criteria (up to June 30, 2017). Read More

    Oral submucous fibrosis in a school-going Indian adolescent boy.
    Int J Adolesc Med Health 2017 Jul 21. Epub 2017 Jul 21.
    .
    A 14-year-old boy presented to our hospital with a chief complaint of difficulty in opening his mouth and a burning sensation on eating spicy food. The oral mucosa showed generalized diffused blanching and he was unable to protrude his tongue. For 6 years he had habitually chewed gutkha - a mixture of betel nut and tobacco for several minutes a day. Read More

    Arecoline activates latent transforming growth factor β1 via mitochondrial reactive oxygen species in buccal fibroblasts: Suppression by epigallocatechin-3-gallate.
    J Formos Med Assoc 2017 Jul 15. Epub 2017 Jul 15.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan. Electronic address:
    Background/purpose: Oral submucous fibrosis (OSF) is a premalignant condition caused by the chewing of areca nut (AN). Transforming growth factor β (TGFβ) plays a central role in the pathogenesis of OSF. Connective tissue growth factor (CTGF or CCN2) and early growth response-1 (Egr-1) are important mediators in the fibrotic response to TGFβ in several fibrotic disorders including OSF. Read More

    Comparison of Extended Nasolabial Flap Versus Buccal Fat Pad Graft in the Surgical Management of Oral Submucous Fibrosis: A Prospective Pilot Study.
    J Maxillofac Oral Surg 2017 Sep 22;16(3):312-321. Epub 2016 Oct 22.
    Department of Oral and Maxillofacial Surgery, Saveetha Dental College and Hospital, Chennai, Tamil Nadu India.
    Aim: To evaluate the application of extended nasolabial flap versus buccal fat pad graft in the surgical management of oral submucous fibrosis.

    Settings And Design: This prospective study was carried out in the Department of Oral and Maxillofacial Surgery, Tamil Nadu Government Dental College and Hospital, Chennai.

    Material And Methods: A total of 8 patients (6 men and 2 women) with age range from 21 to 65 years were selected for study. Read More

    Ki67, CD105, and α-SMA expressions better relate the binary oral epithelial dysplasia grading system of World Health Organization.
    J Oral Pathol Med 2017 Nov 25;46(10):921-927. Epub 2017 Jul 25.
    Department of Oral Pathology and Microbiology, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (M), Wardha, Maharashtra, India.
    Background: The binary system of oral epithelial dysplasia (OED) has never been investigated with reference to the carcinogenesis-related biomarkers. Hence, Ki67, CD105, and α-SMA immune-expressions were studied in oral potentially malignant disorders (OPMDs) to assess their relationship with the binary OED grading system of World Health Organization.

    Methods: The study was carried out on paraffin-embedded tissues of 30 normal oral mucosa (NOM) and 140 OPMD cases. Read More

    Early Stage Oral Submucous Fibrosis is Characterized by Increased Vascularity as Opposed to Advanced Stages.
    J Clin Diagn Res 2017 May 1;11(5):ZC92-ZC96. Epub 2017 May 1.
    Associate Professor, Department of Oral and Maxillofacial Pathology and Microbiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.
    Introduction: The degree of vascularity of the diseased mucosa in Oral Submucous Fibrosis (OSMF) has always been a matter of debate with conflicting results. Knowledge of this aspect is important to understand pathogenesis of OSMF, which in future could be translated into therapeutic strategies.

    Aim: In the present study, attempt has been made to investigate parameters like Mean Vascular Density (MVD), Total Vascular Area (TVA) and Mean Vascular Area (MVA) using CD34 antibody. Read More

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