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    1151 results match your criteria Oral Submucous Fibrosis

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    Serum-based diagnostic prediction of oral submucous fibrosis using FTIR spectrometry.
    Spectrochim Acta A Mol Biomol Spectrosc 2017 Aug 8;189:322-329. Epub 2017 Aug 8.
    School of Medical Science & Technology, Indian Institute of Technology, Kharagpur, India. Electronic address:
    Oral submucous fibrosis (OSF) is found to have the highest malignant potentiality among all other pre-cancerous lesions. However, its detection prior to tissue biopsy can be challenging in clinics. Moreover, biopsy examination is invasive and painful. Read More

    Identification of α-enolase as a prognostic and diagnostic precancer biomarker in oral submucous fibrosis.
    J Clin Pathol 2017 Aug 18. Epub 2017 Aug 18.
    School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, India.
    Aims: Diagnostic ambiguities regarding the malignant potentiality of oral submucous fibrosis (OSF), an oral precancerous condition having dysplastic and non-dysplastic isoforms are the major failure for early intervention of oral squamous cell carcinoma (OSCC) patients. Our goal is to identify proteomic signatures from biopsies that can be used as precancer diagnostic marker for patient suffering from OSF.

    Methods: The high throughput techniques adopting de novo peptide sequencing (1D SDS-PAGE coupled nanoLC MALDI tandem mass spectrometry (MS/MS)-based peptide mass fingerprint), immunohistochemistry (IHC), Western blot (WB) and real-time PCR (RT-PCR) analysis are considered for such biomarker identification and multilevel validations. Read More

    Tobacco Abuse and Associated Oral Lesions among Interstate Migrant Construction Workers.
    J Contemp Dent Pract 2017 Aug 1;18(8):695-699. Epub 2017 Aug 1.
    Department of Oral Pathology and Microbiology, Kannur Dental College, Kannur, Kerala, India.
    Aim: The present study was conducted to assess the prevalence of tobacco use and associated oral mucosal lesions among construction workers of Cochin, Kerala, India.

    Materials And Methods: A cross-sectional study was carried at various construction sites of Cochin and 2,163 workers were selected using multistage sampling method and were interviewed and examined. Information regarding demographic details, form, type, frequency of tobacco use, earlier attempt to quit, and willingness to quit tobacco use was obtained using predesigned questionnaire. Read More

    [Expression of PTPRZ1 in oral squamous cell carcinoma originated from oral submucous fibrosis and its clinical significance].
    Shanghai Kou Qiang Yi Xue 2017 Apr;26(2):198-203
    Department of Oral and Maxillofacial Surgery, Affiliated Haikou Hospital of Xiangya Medical College. Haikou 570208, Hainan Province, China.
    Purpose: This study was aimed to detect the expression of PTPRZ1 in oral squamous cell carcinoma (OSCC) originated from oral submucous fibrosis (OSF), and discuss its role in the development and progression of OSCC originating from OSF as well as its clinical significance.

    Methods: Immunohistochemisty (IHC) and Western blot (WB) for the expression and distribution of PTPRZ1 were carried out in 36 cases of OSF transforming into OSCC, 23 cases of OSCC and 21 cases of healthy controls. The data were analyzed by Chi-square test using SPSS 21. Read More

    [Methods and effects of injection of salvianolic acid B combined with triamcinolone acetonide in the treatment of oral submucous fibrosis].
    Shanghai Kou Qiang Yi Xue 2017 Apr;26(2):188-192
    Department of Oncology, the Third Xiangya Hospital, Central South University. Changsha 410013, Hunan Province, China.
    Purpose: To introduce the methods of triamcinolone acetonide (TA) and salvianolic acid B(SA-B) intralesional injection in the treatment of oral submucous fibrosis and evaluate the treatment effects.

    Methods: TA combined with SA-B were consecutively applied intralesionally 1 time weekly for 30 times. The technique of intralesional injection was that syringe needle be emptied into submucous tissues 1 cm posterior to the corner of oral cavity running from the front to retromolar area by pushing the injection, then the syringe needle retained to the original point and upward from the front to retromolar area by pushing the injection, finally the syringe needle returned to the starting point and downward from the front to retromolar area by pushing the injection. Read More

    Textural pattern classification for oral squamous cell carcinoma.
    J Microsc 2017 Aug 2. Epub 2017 Aug 2.
    Dr. B. Borooah Cancer Research Institute, Guwahati, Assam, India.
    Despite being an area of cancer with highest worldwide incidence, oral cancer yet remains to be widely researched. Studies on computer-aided analysis of pathological slides of oral cancer contribute a lot to the diagnosis and treatment of the disease. Some researches in this direction have been carried out on oral submucous fibrosis. Read More

    Impact of Oral Potentially Malignant Disorders on Quality of Life.
    J Oral Pathol Med 2017 Aug 2. Epub 2017 Aug 2.
    Menzies Health Institute Queensland and School of Dentistry and Oral Health, Griffith University, Queensland, Australia.
    Background: Oral Potentially Malignant Disorders (OPMDs) could have a significant psychological impact on patients, principally because of the unknown risk of malignant transformation, while the physical and functional impairments could differ. This study aimed to assess the impact of three different OPMDs and their disease stages on the Quality of Life (QoL) of affected patients.

    Methods: Oral Leukoplakia (OL), Oral Lichen Planus (OLP) and Oral Submucous Fibrosis (OSF) patients who were undergoing treatment at an oral medicine clinic of a dental teaching hospital in India were the study population. Read More

    Efficacy of oral colchicine with intralesional hyaluronidase or triamcinolone acetonide in the Grade II oral submucous fibrosis.
    Natl J Maxillofac Surg 2017 Jan-Jun;8(1):50-54
    Department of Oral and Maxillofacial Surgery, King George's Medical University, Lucknow, Uttar Pradesh, India.
    Background And Objectives: Oral submucous fibrosis (OSMF) is a potentially malignant disorder of oral mucosa affecting mainly population in South and Southeast Asia. The aim of this study is to compare the effectiveness of oral colchicine with intralesional injection of hyaluronidase or injection triamcinolone acetonide in patients with Grade II OSMF.

    Materials And Methods: The study included thirty patients of clinically diagnosed Grade II OSMF. Read More

    Evaluating the efficacy of pentoxifylline in the treatment of oral submucous fibrosis: a meta-analysis.
    Oral Dis 2017 Jul 24. Epub 2017 Jul 24.
    State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
    Objectives: Oral submucous fibrosis (OSMF), a potentially malignant oral cavity disorder that causes speech and mastication problems, lacks an established treatment regimen; moreover, no treatment can effectively reverse the course of OSMF. A meta-analysis was conducted to investigate the efficacy of the peripheral vasodilator, pentoxifylline, in the treatment of OSMF.

    Methods: We searched five different databases for studies meeting our eligibility criteria (up to June 30, 2017). Read More

    Oral submucous fibrosis in a school-going Indian adolescent boy.
    Int J Adolesc Med Health 2017 Jul 21. Epub 2017 Jul 21.
    .
    A 14-year-old boy presented to our hospital with a chief complaint of difficulty in opening his mouth and a burning sensation on eating spicy food. The oral mucosa showed generalized diffused blanching and he was unable to protrude his tongue. For 6 years he had habitually chewed gutkha - a mixture of betel nut and tobacco for several minutes a day. Read More

    Arecoline activates latent transforming growth factor β1 via mitochondrial reactive oxygen species in buccal fibroblasts: Suppression by epigallocatechin-3-gallate.
    J Formos Med Assoc 2017 Jul 15. Epub 2017 Jul 15.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan. Electronic address:
    Background/purpose: Oral submucous fibrosis (OSF) is a premalignant condition caused by the chewing of areca nut (AN). Transforming growth factor β (TGFβ) plays a central role in the pathogenesis of OSF. Connective tissue growth factor (CTGF or CCN2) and early growth response-1 (Egr-1) are important mediators in the fibrotic response to TGFβ in several fibrotic disorders including OSF. Read More

    Comparison of Extended Nasolabial Flap Versus Buccal Fat Pad Graft in the Surgical Management of Oral Submucous Fibrosis: A Prospective Pilot Study.
    J Maxillofac Oral Surg 2017 Sep 22;16(3):312-321. Epub 2016 Oct 22.
    Department of Oral and Maxillofacial Surgery, Saveetha Dental College and Hospital, Chennai, Tamil Nadu India.
    Aim: To evaluate the application of extended nasolabial flap versus buccal fat pad graft in the surgical management of oral submucous fibrosis.

    Settings And Design: This prospective study was carried out in the Department of Oral and Maxillofacial Surgery, Tamil Nadu Government Dental College and Hospital, Chennai.

    Material And Methods: A total of 8 patients (6 men and 2 women) with age range from 21 to 65 years were selected for study. Read More

    Ki67, CD105, and α-SMA expressions better relate the binary oral epithelial dysplasia grading system of World Health Organization.
    J Oral Pathol Med 2017 Jul 3. Epub 2017 Jul 3.
    Department of Oral Pathology and Microbiology, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (M), Wardha, Maharashtra, India.
    Background: The binary system of oral epithelial dysplasia (OED) has never been investigated with reference to the carcinogenesis-related biomarkers. Hence, Ki67, CD105, and α-SMA immune-expressions were studied in oral potentially malignant disorders (OPMDs) to assess their relationship with the binary OED grading system of World Health Organization.

    Methods: The study was carried out on paraffin-embedded tissues of 30 normal oral mucosa (NOM) and 140 OPMD cases. Read More

    Early Stage Oral Submucous Fibrosis is Characterized by Increased Vascularity as Opposed to Advanced Stages.
    J Clin Diagn Res 2017 May 1;11(5):ZC92-ZC96. Epub 2017 May 1.
    Associate Professor, Department of Oral and Maxillofacial Pathology and Microbiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.
    Introduction: The degree of vascularity of the diseased mucosa in Oral Submucous Fibrosis (OSMF) has always been a matter of debate with conflicting results. Knowledge of this aspect is important to understand pathogenesis of OSMF, which in future could be translated into therapeutic strategies.

    Aim: In the present study, attempt has been made to investigate parameters like Mean Vascular Density (MVD), Total Vascular Area (TVA) and Mean Vascular Area (MVA) using CD34 antibody. Read More

    Patterns of tobacco usage among subjects with potentially malignant oral lesions or conditions in Chennai city: A comparative study.
    J Cancer Res Ther 2017 Apr-Jun;13(2):230-234
    Department of Public Health Dentistry, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India.
    Objective: To determine the patterns of tobacco usage among subjects with potentially malignant oral lesions or conditions through a comparative study design.

    Methods: The study was carried out in a span of 2 months on a sample of 120 subjects; 60 in case group (30 subjects with leukoplakia and oral submucous fibrosis [OSMF], respectively) and 60 subjects in control group (30 current smokers and current chewers, respectively), attending the tobacco cessation clinic at a private dental college hospital in Chennai city. Demographic data, details of tobacco usage, and Fagerstrom nicotine dependence scores (FNTD) were recorded in a prevalidated tobacco cessation intake form. Read More

    Oral squamous cell carcinoma associated with oral submucous fibrosis have better oncologic outcome than those without.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Sep 4;124(3):225-230. Epub 2017 May 4.
    Consultant, MGM Dental College, Navi Mumbai, Maharashtra, India.
    Objective: Oral submucous fibrosis (OSMF) is a potentially malignant disorder associated with the use of areca nut, and is mainly seen in the parts of Southeast Asia and the Indian subcontinent. We hypothesized that oral cancers occurring in presence of OSMF are clinicopathologically a distinct entity.

    Study Design: We analyzed 289 treatment naïve patients of oral cancer. Read More

    Effect of health education on awareness about oral cancer and oral self-examination.
    J Educ Health Promot 2017 5;6:27. Epub 2017 May 5.
    Department of Community Medicine, School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    Context: Oral cancer is preceded by visible changes in the oral mucosa. These lesions can be detected by oral self-examination, but awareness about oral cancer is still low in developing countries.

    Aim: To evaluate the effect of health education on awareness about oral cancer and oral self-examination. Read More

    Effectiveness of Osteopathic Therapy in the Treatment of Oral Submucous Fibrosis.
    Contemp Clin Dent 2017 Jan-Mar;8(1):145-147
    Department of Oral Medicine and Radiology, Maharishi Markandeshwar College of Dental Sciences and Research, Maharishi Markandeshwar University, Ambala, Haryana, India.
    Oral submucous fibrosis (OSMF) is a chronic progressive debilitating disease of oral cavity leading to the stiffness of oral mucosa, burning and trismus resulting in marked rigidity, and an inability to open the mouth. As the medical treatment of OSMF is yet not standardized, the purpose of the present case study was to explore the effectiveness of osteopathic manipulative treatment (OMT) in patients with OSMF. A 30-year-old male presented with a complaint of reduced mouth opening with burning sensation while eating spicy food for 4 years. Read More

    Tanshinone Suppresses Arecoline-Induced Epithelial-Mesenchymal Transition in Oral Submucous Fibrosis By Epigenetically Reactivating the p53 Pathway.
    Oncol Res 2017 May 21. Epub 2017 May 21.
    Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
    Oral submucous fibrosis (OSF) induced by the chewing of areca nut has been considered as a precancerous lesion with a higher probability of developing oral squamous cell carcinoma. Tanshinone (TSN) is the main component extracted from Salvia miltiorrhiza, a traditional Chinese medicine, which was found to have diverse pharmacological effects such as anti-inflammatory and anti-tumor effects. In current study, we aim to identify inhibitory effects and the underlying mechanism of Tanshinone on OSF progress. Read More

    Determination of role of ceruloplasmin in oral potentially malignant disorders and oral malignancy-A cross-sectional study.
    Oral Dis 2017 May 17. Epub 2017 May 17.
    Department of Oral Medicine and Radiology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth University, Vadodara, India.
    Objectives: In the process of carcinogenesis, lipid peroxidation and increased oxidative stress lead to changes in certain antioxidants. This study was aimed to assess and co-relate serum levels of ceruloplasmin in oral premalignancies and oral cancer so as to gauge its possible association with the process of carcinogenesis and to determine its role as tumor marker.

    Material And Methods: The study population comprised of 300 participants, equally divided into six study groups, that is, oral submucous fibrosis (OSMF), oral leukoplakia (OL), nicotina stomatitis (NS), oral malignancy (OM), controls (C), and healthy controls (HC); 5 ml of blood was collected from ante cubital vein from each participant. Read More

    Paediatric oral submucous fibrosis - The neglected pre-malignancy of childhood.
    Int J Pediatr Otorhinolaryngol 2017 Jun 28;97:55-60. Epub 2017 Mar 28.
    Jaypee Hospital, Noida 201301, India.
    Oral submucous fibrosis in children is one of the devastating consequences of arecanut addiction in children. Arecanut is the fourth commonest psychoactive agents used worldwide. However, regrettably, unlike other addictions like tobacco and alcohol, its use in children has become socially acceptable atleast in a few countries. Read More

    Photodynamic treatment outcomes of potentially-malignant lesions and malignancies of the head and neck region: A systematic review.
    J Investig Clin Dent 2017 May 8. Epub 2017 May 8.
    Department of Conservative and Endodontics, HSRS Dental College and Hospital, Hingoli, Maharashtra, India.
    Aim: The aim of the present study was to systematically review the efficacy of photodynamic therapy (PDT) in the management of oral potentially-malignant disorders (PMDS) and head and neck squamous cell carcinoma (HNSCC).

    Methods: From 1985 to 2015, PubMed/Medline, Google Scholar, EMBASE, and ISI Web of Knowledge were searched using different combinations of the following key words: PDT, oral precancer, leukoplakia, erythroplakia, erythroleukoplakia, verrucous hyperplasia, oral submucous fibrosis, and HNSCC. Review articles, experimental studies, case reports, commentaries, letters to the editor, unpublished articles, and articles published in languages other than English were excluded. Read More

    Oral submucous fibrosis: A quantitative assessment of serum malondialdehyde, superoxide dismutase and correlation with clinical staging.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):41-45
    Department of Oral Pathology, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
    Background: Oral submucous fibrosis (OSMF) is a progressive disorder affecting the oral mucosa. OSMF predominantly seen in South-east Asian countries. There are some biochemicals parameters which are modify in oral submucous fibrosis; this alteration can be used as a tool for diseases progress and avert malignant transformation. Read More

    Redefining epithelial characterization in oral submucous fibrosis using morphometric analysis.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):36-40
    Department of Oral and Maxillofacial Pathology and Microbiology, ITS Centre for Dental Studies and Research, Ghaziabad, Uttar Pradesh, India.
    Background: Oral submucous fibrosis (OSMF) is a chronic oral mucosal disease characterized by progressive deposition of collagen in subepithelial connective tissue and epithelial atrophy. The present study was conducted to evaluate the changes in epithelial thickness and cellular and nuclear morphometric characteristics of parabasal and spinous compartments of the epithelium in various stages of OSMF in comparison to normal epithelium.

    Materials And Methods: Sample included 30 cases of OSMF of various stages and five cases of normal buccal mucosa. Read More

    Estimation of hemoglobin, serum iron, total iron-binding capacity and serum ferritin levels in oral submucous fibrosis: A clinicopathological study.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):30-35
    Department of Oral and Maxillofacial Pathology, Mamata Dental College and Hospital, Khammam, Telangana, India.
    Introduction: Oral submucous fibrosis (OSMF) is also considered as an Asian version of sideropenic dysphagia, wherein chronic iron deficiency leads to mucosal susceptibility to irritants, such as chillies and areca nut products. Hemoglobin (Hb) levels, in particular, serum iron levels, are considered as biochemical indicators for nutritional assessment. Serum iron content can thus be a predictor for the progression of the condition, and there appears to be an association between serum iron content and oral carcinogenesis. Read More

    "Clinicobiochemical evaluation of turmeric with black pepper and Nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study"-a commentary.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jun 16;123(6):737. Epub 2017 Mar 16.
    Assistant Professor, Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, India.

    Activation of transforming growth factor-β1 by thrombin via integrins αvβ1, αvβ3, and αvβ5 in buccal fibroblasts: Suppression by epigallocatechin-3-gallate.
    Head Neck 2017 Jul 2;39(7):1436-1445. Epub 2017 May 2.
    School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan.
    Background: Transforming growth factor-beta (TGF-β) plays a central role in the pathogenesis of oral submucous fibrosis (OSF). Thrombin is a key player in tissue repair, inflammation, and fibrosis after injury.

    Methods: Effects of thrombin on activated-TGF-β1 levels, Smad3 phosphorylation, and connective tissue growth factor (CTGF/CCN2) synthesis in primary human buccal mucosal fibroblasts (BMFs) were assessed by enzyme-linked immunosorbent assay or Western blot analysis. Read More

    Reply to: Details of the participants and medical intervention used in the study evaluating the effect of a mouth exercising device on burning sensation in oral submucous fibrosis.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jun 21;123(6):735-737. Epub 2017 Feb 21.
    Lecturer, Department of Orthodontics, Faculty of Dentistry, MAHSA University, Kuala Lumpur, Malaysia.

    Qualitative analysis of the impact of Oral Potentially Malignant Disorders on daily life activities.
    PLoS One 2017 14;12(4):e0175531. Epub 2017 Apr 14.
    Menzies Health Institute Queensland, Griffith University, Queensland, Australia.
    Objective: To evaluate the impact of Oral Potentially Malignant Disorders (OPMD) on daily life activities.

    Materials And Methods: Patients diagnosed with Oral Leukoplakia, Oral submucous fibrosis and Oral Lichen Planus attending the Oral Medicine clinic of Panineeya Institute of Dental Sciences & Research Centre, Hyderabad, India were invited to participate. Eighteen interviews and three focus groups were conducted in a non-clinical setting. Read More

    Genetic changes in oral premalignant lesion, condition, and oral squamous cell carcinoma - A study based on inhibition of G2M phase by colchicines.
    Indian J Dent Res 2017 Jan-Feb;28(1):55-58
    Department of Oral Medicine and Radiology, Farooquia Dental College and Hospital, Mysore, Karnataka, India.
    Aims: To assess the percentage of cell arrested in G2M phase by colchicine in the early detection and prognosis of oral cancer, by comparison of oral squamous cell with leukoplakia and oral submucous fibrosis (OSMF) using flow cytometry analysis.

    Materials And Methods: Biopsy samples 5 each of clinically diagnosed and histopathologically confirmed case of leukoplakia, OSMF, and squamous cell carcinoma (SCC) are included in the study.

    Results: Colchicines significantly inhibited the growth of oral SCC-9 cell line by arresting G2M phase of the cell cycle (94. Read More

    Response to "Commentary on 'Clinicobiochemical evaluation of turmeric with black pepper and nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study'".
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jun 18;123(6):737-738. Epub 2017 Mar 18.
    Department of Oral Medicine and Radiology, College of Dental Sciences, Davangere, Karnataka, India.

    Oral submucous fibrosis: An update on pathophysiology of malignant transformation.
    J Oral Pathol Med 2017 Jul 6;46(6):413-417. Epub 2017 May 6.
    Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Cosham, Portsmouth, UK.
    Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7. Read More

    Oral submucous fibrosis: An update on current theories of pathogenesis.
    J Oral Pathol Med 2017 Jul 4;46(6):406-412. Epub 2017 May 4.
    Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Cosham, Portsmouth, UK.
    Over the last 40 years, many theories linking oral submucous fibrosis (OSMF) to various risk factors have been proposed. Spicy, pungent foods and irritants such as supari (areca nut), paan (betel leaves), tobacco (through chewing or smoking)-the common Asian habits of chewing the aforementioned agents-have all been incriminated as causative agents. Systemic factors such as nutritional deficiency, genetic predisposition and autoimmunity have also been proposed in the pathogenesis of OSMF. Read More

    Current protocols in the management of oral submucous fibrosis: An update.
    J Oral Pathol Med 2017 Jul 4;46(6):418-423. Epub 2017 May 4.
    Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Cosham, Portsmouth, UK.
    Oral submucous fibrosis (OSMF) is a debilitating condition of oral cavity which has significant potential for malignant transformation. In spite of over 20 years of research, the pathogenesis of the condition is still obscure and no single management modality is effective. Many OSMF treatment protocols have been proposed to alleviate the signs and symptoms of the disorder and there is overwhelming evidence that as areca nut is primary cause, stopping its use may have a considerable effect on symptoms rather than reversing pre-existing fibrosis. Read More

    Changes in prevalence of precancerous oral submucous fibrosis from 1996 to 2013 in Taiwan: A nationwide population-based retrospective study.
    J Formos Med Assoc 2017 Apr 5. Epub 2017 Apr 5.
    Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan; School of Dentistry, Chung Shan Medical University, Taichung, Taiwan. Electronic address:
    Background/purpose: Oral submucous fibrosis (OSF) has been regarded as a precancerous condition. Research examining the prevalence of OSF could be the first step in preventing or reducing malignant transformation. In this study, we probed a nationwide registered database to assess the prevalence, gender distribution, age, income, and urbanization status of OSF patients in Taiwan. Read More

    Estimation of Serum Protein in Oral Potentially Malignant Disorders and Oral Malignancy - A Cross-Sectional Study.
    J Clin Diagn Res 2017 Feb 1;11(2):ZC17-ZC19. Epub 2017 Feb 1.
    Reader, Department of Oral Medicine and Radiology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth University , Piparia, Vadodara, Gujarat, India .
    Introduction: In carcinogenesis, increased oxidative stress and weakened antioxidant defense produces damage to the macromolecules like proteins. Thus, protein can act as potential biomarker in oral premalignant and malignant lesions.

    Aim: To determine and compare the levels of serum proteins in Oral Submucuous Fibrosis (OSMF), Oral Leukoplakia (OL), Nicotina Stomatitis (NS), Oral Malignancy (OM) and Healthy Controls (HC). Read More

    Regulation of hypoxia-inducible factor-1α in human buccal mucosal fibroblasts stimulated with arecoline.
    J Formos Med Assoc 2017 Jun 30;116(6):484-487. Epub 2017 Mar 30.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address:
    Hypoxia-inducible factor (HIF)-1α is consistently and dramatically upregulated in a variety of fibrotic diseases. The aim of this study was to compare HIF-1α expression from fibroblasts derived from human normal buccal mucosa and oral submucous fibrosis (OSF) specimens and further to explore the potential mechanisms that may lead to induce HIF-1α expression. OSF buccal mucosal fibroblasts (BMFs) demonstrated significantly higher HIF-1α mRNA expression than normal BMFs (p<0. Read More

    Verrucoid Variant of Invasive Squamous Cell Carcinoma in Oral Submucous Fibrosis: A Clinicopathological Challenge.
    Cureus 2016 Nov 4;8(11):e862. Epub 2016 Nov 4.
    Department of Oral Pathology, Thai Moogambigai Dental College and Hospital.
    Verrucous carcinoma (VC) is an exophytic, low-grade, well-differentiated variant of squamous cell carcinoma. It is described as a lesion appearing in the sixth or seventh decade of life that has minimal aggressive potential and, in long-standing cases, has been shown to transform into squamous cell carcinoma. Oral submucous fibrosis (OSMF) is a potentially malignant disorder, and about one-third of the affected population develop oral squamous cell carcinoma. Read More

    Micronutrients and Their Role in Oral Cancer: A Review.
    West Indian Med J 2016 Mar 15;65(2):383-388. Epub 2016 Mar 15.
    Department of Oral Medicine and Radiology, AB Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, India.
    Cancer is one of the leading causes of death across the world. Oral cancer is the sixth most common type of cancer in the world. The incidence of oral cancer increases with the increase in the consumption of carcinogens such as tobacco and alcohol as seen in south and southeast Asia. Read More

    Complications in the use of bilateral inferiorly based nasolabial flaps for advanced oral submucous fibrosis.
    Natl J Maxillofac Surg 2016 Jul-Dec;7(2):115-121
    Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Deemed University, Dental College and Hospital, Pune, Maharashtra, India.
    Surgical management of advanced oral submucous fibrosis (OSMF) using bilateral inferiorly based nasolabial flaps is becoming increasingly popular. However no comprehensive analysis of delayed complications using this technique is available in the literature. The authors have conducted a retrospective study to examine the delayed complications of bilateral inferiorly based nasolabial flaps used in advanced oral submucous fibrosis at their institute along with a detailed review of literature on the subject. Read More

    [Epidemiological investigation of chewing fresh or dried betel nut and oral mucosal disease].
    Hua Xi Kou Qiang Yi Xue Za Zhi 2016 Aug;34(4):391-394
    Dept. of Oral Mucosa Diseases, Hainan Provincial Stomatology Center, Affiliate Haikou Hospital of Xiangya Medical School, Central South University, Haikou 570208, China.
    Objective: This study was conducted to investigate the effect of chewing fresh or dried betel nut on the inci-dence and canceration of oral mucosa disease in Haikou City in Hainan Province.

    Methods: Through a survey questionnaire, clinical examination, and regular follow-up, we collected clinical data from 1 722 cases and divided them into two groups, among which 704 of the afflicted people chew dried betel nut, whereas the other 1 018 chew fresh betel nut. The data were 
statistically analyzed using different variables which included age, number, time of onset of the disease, and the cancerous condition associated with common oral mucosa disease, including oral submucous fibrosis (OSF), oral leukoplakia (OLK), and oral Lichen planus (OLP). Read More

    Pan masala habits and risk of oral precancer: A cross-sectional survey in 0.45 million people of North India.
    J Oral Biol Craniofac Res 2017 Jan-Apr;7(1):13-18. Epub 2016 Dec 29.
    Roseman University of Health Sciences, Henderson, NV, United States.
    Objectives: This cross-sectional community based study was conducted to estimate the prevalence of consumption habits for non tobacco pan masala (ASU) and the risk of developing oral precancer in North India.

    Methods: This study was conducted in the old town of Lucknow city in the state of Uttar Pradesh in India. Subjects residing for more than 6 months and aged 15 years or above, were enrolled in the study after their informed consent. Read More

    Analysis of silver binding nucleolar organizer regions in exfoliative cytology smears of potentially malignant and malignant oral lesions.
    Biotech Histochem 2017 1;92(2):115-121. Epub 2017 Mar 1.
    e Department of Oral Medicine and Radiology , Pacific Dental College and Hospital , Udaipur , Rajasthan , India.
    Nucleolar organizer regions are nucleolar components that contain proteins that are stained selectively by silver methods; they can be identified as black dots throughout the nucleolus and are known as silver binding nucleolar organizer regions (AgNOR). The number of AgNOR is related to the cell cycle and the proliferative activity of the cells. We investigated AgNOR using exfoliative cytology smears of potentially malignant oral lesions. Read More

    Malignant transformation of oral submucous fibrosis in Taiwan: A nationwide population-based retrospective cohort study.
    J Oral Pathol Med 2017 Mar 14. Epub 2017 Mar 14.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
    Background: Oral submucous fibrosis (OSF) is one of the well-recognized oral potentially malignant disorders. In this study, we investigated the malignant transformation of OSF in a Taiwanese population.

    Methods: A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. Read More

    Smokeless tobacco (paan and gutkha) consumption, prevalence, and contribution to oral cancer.
    Epidemiol Health 2017 9;39:e2017009. Epub 2017 Mar 9.
    International Campus, Tehran University of Medical Sciences (IC-TUMS), Tehran, Iran.
    Smokeless tobacco consumption, which is widespread throughout the world, leads to oral submucous fibrosis (OSMF), which is a long-lasting and devastating condition of the oral cavity with the potential for malignancy. In this review, we mainly focus on the consumption of smokeless tobacco, such as paan and gutkha, and the role of these substances in the induction of OSMF and ultimately oral cancer. The list of articles to be examined was established using citation discovery tools provided by PubMed, Scopus, and Google Scholar. Read More

    Evaluation of Efficacy of Intraligamentary Injection Technique for Extraction of Mandibular Teeth-A Prospective Study.
    J Clin Diagn Res 2017 Jan 1;11(1):ZC110-ZC113. Epub 2017 Jan 1.
    Associate Professor, Department of Oral and Maxillofacial Surgery, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth , Pune, Maharashtra, India .
    Introduction: Fear of dental pain is one of the most common reasons for delaying dental treatment. Local Anaesthesia (LA) is the most commonly employed technique of achieving pain control in dentistry. Pterygomandibular Nerve Block (PNB), for achieving mandibular anaesthesia has been the traditional technique used and is associated with a few set of complications which include pain, nerve injury, trismus, and rarely facial nerve palsy, and sustained soft tissue anaesthesia. Read More

    Environmental heavy metal as a potential risk factor for the progression of oral potentially malignant disorders in central Taiwan.
    Cancer Epidemiol 2017 Apr 2;47:118-124. Epub 2017 Mar 2.
    Graduate Institute of Statistics and Information Science, National Changhua University of Education, Changhua 500, Taiwan. Electronic address:
    Objective: Oral cancer (OC) is a leading cause of death from cancer in men between the ages of 25 and 44 years in Taiwan. The overall 5-year survival rates for the four OC stages (I-IV) in Taiwan are approximately 70%, 30%, 20%, and 10%, respectively, indicating the importance of the early diagnosis of oral potentially malignant disorders (OPMDs). Previous studies indicated an association between the OC incidence and certain environmental heavy metal concentrations. Read More

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