Hinokitiol ablates myofibroblast activation in precancerous oral submucous fibrosis by targeting Snail.
- Hui-Wen Yang,
- Ming-Yi Lu,
- Yu-Wei Chiu,
- Yi-Wen Liao,
- Yu-Feng Huang,
- Pin Ju Chueh,
- Pei-Ling Hsieh,
- Cheng-Chia Yu
Environ Toxicol 2018 Jan 12. Epub 2018 Jan 12.
School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
Oral submucous fibrosis (OSF) is a precancerous condition with symptoms of limited mouth opening and areca nut chewing habit has been implicated in its pathogenesis. Hinokitiol, a natural tropolone derived from Chamacyparis taiwanensis, has been reported to improve oral lichen planus and inhibit various cancer cells. Here, we showed that hinokitiol reduced the myofibroblast activities in fBMFs and prevented the arecoline-induced transdifferentiation. Read More