1,454 results match your criteria Oral Submucous Fibrosis


[Modern perspectives of oral squamous cell carcinoma].

Authors:
A A Ivina

Arkh Patol 2020 ;82(3):55-60

Peoples' Friendship University of Russia, Moscow, Russia.

The article is devoted to the modern perspectives of the etiology, pathogenesis, diagnosis and prognostic factors in theoral squamous cell carcinoma. In the new edition of the WHO Classification of Head and Neck Tumors of 2017, the concept of potentially malignant diseases is introduced, which include erythroplakia, leukoplakia, oral submucous fibrosis, dyskeratosiscongenita, smokeless tobacco keratosis, palatallesions associated with reverse smoking, chronic candidiasis, lichen planus, discoid lupus erythematosus, syphilitic glossitis and actinic keratosis (liponly). A binary system for assessing oral epithelial dysplasia assessing is proposed. Read More

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http://dx.doi.org/10.17116/patol20208203155DOI Listing
January 2020

Positive Feedback Loop of SNAIL-IL-6 Mediates Myofibroblastic Differentiation Activity in Precancerous Oral Submucous Fibrosis.

Cancers (Basel) 2020 Jun 18;12(6). Epub 2020 Jun 18.

School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan.

Oral submucosal fibrosis (OSF) is a premalignant disorder of the oral cavity, and areca nut chewing is known to be a major etiological factor that could induce epithelial to mesenchymal transition (EMT) and activate buccal mucosal fibroblasts (BMFs). However, this detailed mechanism is not fully understood. In this study, we showed that the upregulation of Snail in OSF samples and fibrotic BMFs (fBMFs) may result from constant irritation by arecoline, a major alkaloid of the areca nut. Read More

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http://dx.doi.org/10.3390/cancers12061611DOI Listing

Reasons for Initiation of Areca Nut and Related Products in Patients with Oral Submucous Fibrosis within an Endemic Area in Gujarat, India.

Subst Use Misuse 2020 ;55(9):1413-1421

Menzies Health Institute Queensland, Griffith University, Queensland, Australia.

: While the patterns of consumption of areca nut and its by-products (ANBP) vary across South Asia and the rest of the world, all users share the probable severe outcome of oral submucous fibrosis (OSMF), and this is well reported. The role of psychosocial drivers of habit initiation and addiction is reported less. : To reveal the burden of ANBP abuse, exploring the psychosocial relationship between sex, age at first exposure (AFE), the reason for initiation (RFI) with the type of habit (TOH). Read More

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http://dx.doi.org/10.1080/10826084.2019.1660678DOI Listing
January 2020

Turmeric in the management of oral submucous fibrosis - A systematic review and meta-analysis.

Authors:
Ekta Ingle

Int J Health Sci (Qassim) 2020 May-Jun;14(3):41-46

Department of Oral and Maxillofacial Radiology and Diagnostic Sciences, Riyadh Elm University, Riyadh, Kingdom of Saudi Arabia.

Objectives: Oral submucous fibrosis (OSMF), a premalignant condition, is frequently occur in the buccal mucosa and is associated with betel nut chewing. Various treatment modalities are tested to treat this condition. An effective intervention is needed, which is cost effective, safe, and efficient, considering the disease burden in high incident countries. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269620PMC

Genetic Implications of HLA-DR and HLA-DQ Genotype on Tobacco Smoking and Oral Submucous Fibrosis.

Oral Health Prev Dent 2020 ;18(3):455-460

Purpose: Integration of genetic information into our understanding of oral diseases has fostered the hope to intervene the disease process among genetically susceptible individuals. Oral submucous fibrosis (OSF) (mainly in the Southeast Asia region) and tobacco smoking are two of the major public health problems the world is facing today. With more and more diseases being associated with alleles of the human leukocyte antigen (HLA), the objective of the study was to explore any genetic association of OSF and smoking behaviour with specific HLA Class II DQB1*0503 and HLA DRB1*0301 alleles. Read More

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http://dx.doi.org/10.3290/j.ohpd.a44683DOI Listing

Treatment outcomes of laser therapy in oral submucous fibrosis-a systematic review.

J Oral Biol Craniofac Res 2020 Jul-Sep;10(3):253-258. Epub 2020 May 18.

Department of Oral Pathology & Microbiology, People's College of Dental Science & Research, Bhopal, Madhya Pradesh, India.

Background: The mainstay of oral submucous fibrosis (OSF) management is to increase the mouth opening; thereby improving oral functionalities. In modernized dentistry, laser therapy (LT) could play a major role for trismus relief in OSF patients. The present review was performed to systematically analyze the published literature on LT for OSF management. Read More

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http://dx.doi.org/10.1016/j.jobcr.2020.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264056PMC

Malignant potentiality assessment of oral submucous fibrosis through semi-quantitative approach.

J Oral Maxillofac Pathol 2020 Jan-Apr;24(1):188. Epub 2020 May 8.

Department of Mathematics, Indian Institute of Technology, Kharagpur, West Bengal, India.

Background: In the context of early diagnosis and prevention of oral cancer, precise assessment of malignant potentiality of the oral potentially malignant disorders, particularly oral submucous fibrosis (OSF) is crucial. Till date, the assessment of malignant potentiality suffers from predictive ambiguity due to the lack of precision in the gold standard techniques. This can be addressed by integrating heuristic domain knowledge with quantitative analysis. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_297_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269314PMC

Assessment of lactate dehydrogenase enzyme levels in saliva and serum of oral submucous fibrosis and leukoplakia patients.

J Oral Maxillofac Pathol 2020 Jan-Apr;24(1):183. Epub 2020 May 8.

Department of Oral Pathology and Microbiology, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology Deemed to be University, Bhubaneswar, Odisha, India.

Background: Pathology involving the oral epithelium may alter the level of salivary concentration of LDH. Thus its estimation can be used as a non invasive screening tool for the early detection of OPMDs and also to predict its malignant transformation especially in high risk population.

Aims And Objectives: To evaluate the salivary and serum levels of lactate dehydrogenase (LDH) in patients having of oral submucous fibrosis (OSMF) and leukoplakia and compare it with healthy individuals. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_214_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269293PMC

Qualitative expression of hypoxia-inducible factor-1α in malignant transformation of oral submucous fibrosis: An immunohistochemical study.

J Oral Maxillofac Pathol 2020 Jan-Apr;24(1):106-112. Epub 2020 May 8.

Department of Oral and Maxillofacial Pathology and Microbiology, D. Y. Patil Deemed to be University School of Dentistry, Navi Mumbai, Maharashtra, India.

Background: Oral submucous fibrosis (OSF) is a precancerous condition predominantly seen in people of Asian descent. About 7%-12% of OSF patients develop oral squamous cell carcinoma. Morphological features of OSF, especially fibrosis, suggest a possibility of hypoxic environment in diseased tissues. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_234_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269283PMC

Serum C-reactive protein in oral submucous fibrosis and oral squamous cell carcinoma: A cross-sectional study.

J Oral Maxillofac Pathol 2020 Jan-Apr;24(1):46-51. Epub 2020 May 8.

Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Nagpur, Maharashtra, India.

Context: Early detection of oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSMF) transforming into malignancy can drastically improve the treatment outcomes and prognosis. Carcinoma development is an intricate complex mechanism and the multifactorial causation makes it more difficult to find specific prognostic and therapeutic biomarkers. Thus, the development of newer diagnostic and predictive approaches that are less invasive, economical and amenable to repeated sampling is imperative. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_317_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269289PMC

Study of Hypoxia-inducible factor-2α expression in the malignant transformation of Oral submucous fibrosis.

J Oral Maxillofac Pathol 2020 Jan-Apr;24(1):33-39. Epub 2020 May 8.

Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India.

Context: Hypoxia-inducible factor (HIF)-2α is overexpressed in primary and metastatic human cancers, whose expression is correlated with tumor angiogenesis and patient mortality. HIF plays a role in the progression of fibrosis in oral submucous fibrosis (OSF).

Aim And Objective: The aim is to study and compare the expression of HIF-2α in OSF (a), oral squamous cell carcinoma (OSCC) with areca nut usage (b), OSCC without areca nut usage (c) and normal mucosa (d) by immunohistochemistry. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_42_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269270PMC

Oral submucous fibrosis and COVID-19: Perspective on comorbidity.

Oral Oncol 2020 May 21:104811. Epub 2020 May 21.

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

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http://dx.doi.org/10.1016/j.oraloncology.2020.104811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241316PMC

Expression of transforming growth factor beta in oral submucous fibrosis.

J Oral Biol Craniofac Res 2020 Apr-Jun;10(2):166-170. Epub 2020 Apr 13.

Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.

Background: Oral submucous fibrosis (OSMF) is a premalignant condition mainly caused by areca nut chewing and is characterized by progressive fibrosis of submucosal tissues and epithelial atrophy. Activation of transforming growth factor beta (TGF-β) signaling is considered main causative event for increased collagen production and fibrosis. In this study, molecular pathogenesis of OSMF was investigated based on the expression of the TGF-β genes in OSMF tissues compared to normal controls. Read More

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http://dx.doi.org/10.1016/j.jobcr.2020.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254463PMC

Patterns of Tobacco Use and its Relation to Oral Precancers and Cancers among Individuals Visiting a Tertiary Hospital in South India.

J Contemp Dent Pract 2020 Mar 1;21(3):304-309. Epub 2020 Mar 1.

Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Mangaluru, Karnataka, India.

Aim: The aim of this study was to evaluate the use of tobacco and its association with oral precancers and cancers.

Materials And Methods: Medical records of 1,007 individuals were assessed for the patterns of tobacco abuse and the presence of tobacco-related oral mucosal alterations.

Results: This study comprised 1,007 individuals (M:F: 95. Read More

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DNA content abnormality in oral submucous fibrosis concomitant leukoplakia: A preliminary evaluation of the diagnostic and clinical implications.

Diagn Cytopathol 2020 May 20. Epub 2020 May 20.

Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.

Oral submucous fibrosis (OSF) is an insidious chronic oral and oropharyngeal potentially malignant disorder. Our previously studies reported that DNA image cytometry (ICM) using brushing added in the diagnosis of high-grade dysplasia and staging of oral leukoplakia (OLK). This preliminary study aimed to investigate the abnormal rate of DNA content in 30 cases of OSF including three cases of OSF concomitant OLK and evaluate their the diagnostic and clinical implications with special emphasis on the OSF concomitant OLK. Read More

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http://dx.doi.org/10.1002/dc.24469DOI Listing

Photobiomodulation therapy inhibits oral submucous fibrosis in mice.

Oral Dis 2020 May 11. Epub 2020 May 11.

School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Objectives: Oral submucous fibrosis (OSMF) is a chronic inflammatory disease and a potentially malignant oral disorder. However, the best therapeutic treatment for OSMF remains uncertain. Our previous study showed that photobiomodulation (PBM) therapy and forskolin could reduce arecoline-induced fibrosis reactions via the cAMP pathway. Read More

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http://dx.doi.org/10.1111/odi.13409DOI Listing

Evaluation and Expression of Survivin in Potentially Malignant Lesions and Squamous Cell Carcinoma: A Comparative Study.

Cureus 2020 Apr 5;12(4):e7551. Epub 2020 Apr 5.

Oral and Maxillofacial Surgery, Thai Moogambigai Dental College and Hospital, Chennai, IND.

Introduction Overexpression of survivin, an anti-apoptotic protein, has been associated with the progression of cancer, resistance to drugs, and a poor prognosis. The expression level of survivin indicates the progression of the disease, early recurrence, and a failure to respond to therapy. Our study was a retrospective analysis performed on archival specimens. Read More

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http://dx.doi.org/10.7759/cureus.7551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202583PMC

Comparison of Efficacy of Topical Curcumin Gel with Triamcinolone-hyaluronidase Gel Individually and in Combination in the Treatment of Oral Submucous Fibrosis.

J Contemp Dent Pract 2020 Jan 1;21(1):83-90. Epub 2020 Jan 1.

Department of Prosthodontics, Dr Hedgewar Smruti Rugna Seva Mandal Dental College and Hospital, Hingoli, Maharashtra, India.

Aim: To study the efficacy of topical curcumin mucoadhesive semisolid gel, triamcinolone acetonide/hyaluronidase mucoadhesive semisolid gel, and a combination of both in the treatment of oral submucous fibrosis (OSMF).

Materials And Methods: One hundred and twenty patients diagnosed with OSMF were randomly divided into groups I, II, and III. Each patients in groups I, II, and III was given professionally prepared mucoadhesive semisolid gel of curcumin, a combination of triamcinolone acetonide and hyaluronidase mucoadhesive semisolid gel, and a combination of all three, respectively. Read More

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January 2020

Comparative Evaluation of Mitochondrial Antioxidants in Oral Potentially Malignant Disorders.

Kurume Med J 2020 May 1. Epub 2020 May 1.

AL-FALAH School of Medical Sciences and Research Center, AL- Falah University.

Various endogenous mitochondria-associated antioxidants protect mitochondria from oxidative stresses such as Superoxide Dismutase 2 (SOD2), Catalase, Glutaredoxin 2 (GLRX2), educed Glutathione (GSH), Glutathione Peroxidase (GPx), and Thioredoxin 2 (TXN2). They protect mitochondria from Reactive Oxygen Species (ROS). Excess ROS causes mitochondrial DNA damage and respiratory chain dysfunction leading to carcinogenesis. Read More

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http://dx.doi.org/10.2739/kurumemedj.MS661009DOI Listing

No age predilection for a disease like OSMF. A case report of 5-year-old child.

J Oral Biol Craniofac Res 2020 Apr-Jun;10(2):153-157. Epub 2020 Apr 10.

Dept of Public Health Dentistry, K M Shah Dental College and Hospital, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.

Background: Oral Sub Mucous Fibrosis (OSMF) is a clinical entity, well known since the time of Sushruta as 'Vidari'. OSMF is a chronic subtle disease that is associated with significant functional morbidity and an increased risk for malignancy. Generally, OSMF is considered as an adult disease, but recently Indian suburb area has reported incidence of 0. Read More

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http://dx.doi.org/10.1016/j.jobcr.2020.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183204PMC

Impact of Oral Submucous Fibrosis on Quality of Life: A Multifactorial Assessment.

J Maxillofac Oral Surg 2020 Jun 25;19(2):251-256. Epub 2019 Jan 25.

5Trauma and Emergency, AIIMS Jodhpur, Jodhpur, Rajasthan India.

Background: Oral submucous fibrosis (OSMF) has been extensively researched for its etiopathogenesis, malignant potential, and various available treatment modalities, but its effect on different domains of patient's life has not been thoroughly investigated. The present study aimed to clearly construe the effects of OSMF like severity and demographic variables on different domains of quality of life in OSMF patients.

Methods: A cross-sectional study was conducted in the Department of Dentistry, AIIMS Jodhpur, India. Read More

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http://dx.doi.org/10.1007/s12663-019-01190-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176758PMC

LINC00312/YBX1 Axis Regulates Myofibroblast Activities in Oral Submucous Fibrosis.

Int J Mol Sci 2020 Apr 23;21(8). Epub 2020 Apr 23.

Department of Anatomy, School of Medicine, China Medical University, Taichung 404, Taiwan.

Oral submucous fibrosis (OSF) has been recognized as a precancerous disorder in the oral cavity. Great effort has been made to inhibit the malignant progression of OSF over the past decades, but the cure of this fibrosis disease has not been discovered. In the present study, we found that a long noncoding RNA, LINC00312, was upregulated in OSF tissues, and positively associated with several fibrosis factors, such as α-SMA, type I collagen, and fibronectin. Read More

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http://dx.doi.org/10.3390/ijms21082979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215884PMC

In vitro Quantification of Collagen and Snail1 Gene Expression in Experimentally Induced Fibrosis by Arecoline and Commercial Smokeless Tobacco Products.

Asian Pac J Cancer Prev 2020 Apr 1;21(4):1143-1148. Epub 2020 Apr 1.

Index Institute of Dental Sciences Indore, India.

Introduction: Extracellular matrix component derangement is the major event in pathogenesis of Oral submucous fibrosis. Many studies have elaborated the alteration of the matrix components at a cellular and genetic level. However elaborate quantification of the components with varying concentrations of Areca nut extract  and commercial tobacco products have not been done so far. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.4.1143DOI Listing

Expression of Salivary S100A7 Levels in Stage I Oral Submucous Fibrosis: A Clinical and Laboratory Study.

Asian Pac J Cancer Prev 2020 Apr 1;21(4):1115-1119. Epub 2020 Apr 1.

Research Chair for Biological Research in Dental Health, Riyadh, Saudi Arabia.

Background: Oral submucous fibrosis (OSF) is a chronic debilitating condition characterized by juxta-epithelial fibrosis. The main etiological agent associated with the high-risk precancerous condition is areca nut use. S100A7 is a member of the largest calcium-binding proteins exclusively found in vertebrates and are associated with the regulation of numerous intracellular and extracellular functions. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.4.1115DOI Listing

Prevalence of oral premalignant lesions and conditions among the population of Kanpur City, India: A cross-sectional study.

J Family Med Prim Care 2020 Feb 28;9(2):1080-1085. Epub 2020 Feb 28.

Department of Public Health Dentistry, King George Medical University, Lucknow, Uttar Pradesh, India.

Background: The habit of smoking and chewing tobacco is associated with various types of oral mucosal lesions and conditions, many of which pose a potential threat to cancer growth. The present study aims to evaluate the prevalence of potentially malignant lesions (PML) and oral cancer in North India and to identify the associated risk factors.

Materials And Methods: A cross-sectional study was carried out in the Department of Oral Medicine and Radiology Rama Dental College Hospital and research center Kanpur over a period of 5 years with1,10,625 patients. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_912_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114062PMC
February 2020

Evaluation of Efficacy of Curcumin along with Lycopene and Piperine in the Management of Oral Submucous Fibrosis.

Contemp Clin Dent 2019 Jul-Sep;10(3):531-541

Oral Health Division, Multidisciplinary Organizations for Technical and Health Education and Research, Kolkata, West Bengal, India.

Context: Oral submucous fibrosis (OSMF) is a high-risk premalignant condition of the oral cavity and oropharynx. Complete regression of the disease is still not possible with available treatment modalities.

Aims: The aim of the study was to evaluate the efficacy of curcumin, lycopene, and piperine as a combination in the management of OSMF. Read More

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http://dx.doi.org/10.4103/ccd.ccd_937_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150573PMC

Appearance of a primary in a case of 'carcinoma unkown primary' with advanced oral submucous fibrosis.

Oral Oncol 2020 Apr 15:104716. Epub 2020 Apr 15.

Head Neck Surgical Oncology & Robotic Surgery, HealthCare Global (HCG) Cancer Centre, India. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2020.104716DOI Listing
April 2020
3.607 Impact Factor

Proliferative ability and accumulation of cancer stem cells in oral submucous fibrosis epithelium.

Oral Dis 2020 Apr 8. Epub 2020 Apr 8.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Objectives: The driving force of the malignant transformation of epithelial cells during oral submucous fibrosis (OSF) is an unsettled debate. We hypothesized that the expression and accumulation of cancer stem cells (CSCs) are accompanied by epithelial atrophy in OSF.

Materials And Methods: The expression levels of Ki67 (proliferation marker), SOX2, and Bmi1 (CSC marker) in the epithelium during the early, middle, and late stages of OSF were measured by immunohistochemistry. Read More

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http://dx.doi.org/10.1111/odi.13347DOI Listing
April 2020
2.427 Impact Factor

miR-10b regulated by Twist maintains myofibroblasts activities in oral submucous fibrosis.

J Formos Med Assoc 2020 Jul 4;119(7):1167-1173. Epub 2020 Apr 4.

School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan; Division of Oral and Maxillofacial Surgery, Department of Dentistry, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address:

Background/purpose: Oral submucous fibrosis (OSF) is an oral precancerous disorder associated with the habit of areca nut chewing. MiR-10b has been shown to be upregulated in the oral cancer cells and induced by Twist. Our previous work has revealed that Twist participated in the pathogenesis of OSF and therefore we aimed to investigate whether Twist/miR-10b axis was involved in the activation of myofibroblast in the oral cavity. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.03.005DOI Listing

[Potentially malignant disorders of the oral mucosa].

Authors:
Lotfi Ben Slama

Rev Prat 2019 Oct;69(8):856-860

Service de stomatologie et chirurgie maxillofaciale, groupe hospitalier Pitie-Salpêtrière- Charles Foix, département hospitalouniversitaire Fight Ageing and STress (DHU FAST) Paris, France ; Sorbonne Universités, UPMC Université de Paris 06, UMR 8256 B2A, Paris, France.

Potentially malignant disorders of the oral mucosa. The term "precancerous" is now abandoned in favor to « potentially malignant disorder » which provide a better view of the evolution a far from systematic. Of these disorders, leukoplakia is the most common while erythroplakia is rare. Read More

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October 2019

The use of Velscope to assess cellular changes occuring in oral premalignancy.

J Oral Biol Craniofac Res 2020 Apr-Jun;10(2):99-103. Epub 2020 Mar 14.

Dept. of Oral and Maxillofacial Surgery, Dr. D.Y. Patil Vidyapeeth, Pune, India.

Objectives: To improve visualization of suspicious lesions of the oral mucosa and to assess the accuracy of Velscope in assessing cellular changes occurring in oral premalignancy for early diagnosis.

Materials And Methods: In this prospective, randomized in-vivo clinical study a total of 250 patients who gave history of chewing tobacco were screened. The selection of the site of biopsy was taken based on the area of loss of fluorescence identified by the Velscope within the lesion. Read More

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http://dx.doi.org/10.1016/j.jobcr.2020.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082544PMC

Network-based identification of signature genes KLF6 and SPOCK1 associated with oral submucous fibrosis.

Mol Clin Oncol 2020 Apr 30;12(4):299-310. Epub 2020 Jan 30.

Translational Research Lab, Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi 110025, India.

The molecular mechanism of oral submucous fibrosis (OSF) is yet to be fully elucidated. The identification of reliable signature genes to screen patients with a high risk of OSF and to provide oral cancer surveillance is therefore required. The present study produced a filtering criterion based on network characteristics and principal component analysis, and identified the genes that were involved in OSF prognosis. Read More

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http://dx.doi.org/10.3892/mco.2020.1991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058035PMC

Histopathology of Oral Submucous Fibrosis in Third Dimension with an Additional note on Hypothesis of Epithelial Atrophy.

J Microsc Ultrastruct 2020 Jan-Mar;8(1):31-34. Epub 2019 Nov 29.

Department of Oral and Maxillofacial Pathology and Microbiology, D. Y. Patil Deemed to be University, School of Dentistry, Nerul, Navi Mumbai, Maharashtra, India.

Oral submucous fibrosis (OSMF) is a potentially malignant disorder, characterized by progressive fibrosis of the lamina propria and underlying connective tissue. It has high chances of malignant transformation. It is caused by betel nut which is very common habit among Indians. Read More

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http://dx.doi.org/10.4103/JMAU.JMAU_23_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045625PMC
November 2019

Evaluation of Ki-67 Expression in Oral Submucous Fibrosis and Its Correlation with Clinical and Histopathological Features.

J Microsc Ultrastruct 2020 Jan-Mar;8(1):20-24. Epub 2019 Nov 8.

Department of Oral and Maxillofacial Pathology and Microbiology, D. Y. Patil Deemed to be University School of Dentistry, Navi Mumbai, Maharashtra, India.

Objectives: Oral submucous fibrosis (OSMF) is a potentially malignant disorder. Although it shows atrophic epithelium, it has a high proliferative capacity. Therefore, this study correlates the Ki-67. Read More

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http://dx.doi.org/10.4103/JMAU.JMAU_28_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045623PMC
November 2019

Efficacy of hyaluronidase combined with corticosteroids in treatment of oral submucous fibrosis: A meta-analysis of randomized controlled clinical trials.

J Oral Pathol Med 2020 Apr 5;49(4):311-319. Epub 2020 Apr 5.

Changsha Stomatological Hospital, Changsha, China.

Objective: This meta-analysis was performed to systematically evaluate the efficacy of hyaluronidase combined with corticosteroids compared with other drugs in improving maximum mouth opening and alleviating the burning sensation in patients with oral submucous fibrosis (OSF).

Methods: PubMed, Embase, Web of Science and the Cochrane Library were searched. RevMan 5. Read More

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http://dx.doi.org/10.1111/jop.13009DOI Listing

Human papillomavirus prevalence in oral potentially malignant disorders: Systematic review and meta-analysis.

Oral Dis 2020 Mar 6. Epub 2020 Mar 6.

Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

Objectives: We aimed to provide pooled estimates of human papillomavirus (HPV) prevalence in oral potentially malignant disorders (OPMD) and evaluate the impact of presence of epithelial dysplasia.

Methods: We searched PubMed, Embase, and Cochrane Library databases for studies that examined the prevalence of HPV DNA in OPMD tested by polymerase chain reaction (PCR).

Results: Across 52 eligible studies (2,677 cases), we found an overall pooled HPV prevalence of 22. Read More

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http://dx.doi.org/10.1111/odi.13322DOI Listing

Role of autophagy and apoptosis in atrophic epithelium in oral submucous fibrosis.

J Oral Sci 2020 Mar 4;62(2):184-188. Epub 2020 Mar 4.

Centre of Stomatology, Xiangya Hospital, Central South University.

Oral submucous fibrosis (OSF) is a serious, potentially malignant oral disorder. It is histopathologically characterized by chronic inflammation and atrophic epithelium accompanied by the accumulation of collagen fibers in the lamina propria. The molecular mechanisms leading to atrophic epithelium remain poorly understood. Read More

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http://dx.doi.org/10.2334/josnusd.19-0170DOI Listing

Study on the expression and function of smad family member 7 in oral submucous fibrosis and oral squamous cell carcinoma.

Arch Oral Biol 2020 Apr 24;112:104687. Epub 2020 Feb 24.

Oral Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410000, China. Electronic address:

Objective: To investigate the expression and function of smad family member 7 (SMAD7) in the progress of oral submucous fibrosis (OSF) and oral squamous cell carcinoma (OSCC).

Methods: Mucosa tissue microarray containing 12 normal oral mucosa samples, 69 OSF samples, 28 OSCC sample and paired adjacent tissues was used to explore the expression levels in OSF and OSCC by immunochemistry. Several online bioinformatics analysis tools were used to explore "transcriptome level" and mostly probable "functions and pathways" of SMAD7 in head and neck squamous cell carcinoma. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104687DOI Listing
April 2020
1.880 Impact Factor

Comparative Evaluation of SMAD-2 Expression in Oral Submucous Fibrosis and Reactive Oral Lesions.

Asian Pac J Cancer Prev 2020 Feb 1;21(2):399-403. Epub 2020 Feb 1.

Department of Oral Pathology and Microbiology, SRM Dental College, SRM University, Chennai, India.

Background: The event of fibrosis encompasses involvement of definite immunological and molecular mechanisms. As quite a lot of pro-fibrotic pathways are concerned, a multipronged approach is obligatory to cognize the fibrotic events. SMAD signaling pathway hasn't been studied oral fibrotic events. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.2.399DOI Listing
February 2020

Expression profile of salivary micro RNA-21 and 31 in oral potentially malignant disorders.

Braz Oral Res 2020 10;34:e002. Epub 2020 Feb 10.

Saveetha University, Saveetha Dental College, Department of Oral and Maxillofacial Pathology, Chennai, Tamil Nadu, India.

Oral potentially malignant disorders (OPMD) possess significant chances of malignancy conversion. In order to develop an early diagnostic tool, the present study evaluated the expression of miRNA-21 and 31 as salivary markers. The case-control study was carried out in 36 healthy participants as controls and in 36 patients who were newly diagnosed as OPMD having four different lesions including leucoplakia, oral sub mucous fibrosis (OSMF)궱, oral lichen planus, and (OSMF)궱 with leucoplakia. Read More

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http://dx.doi.org/10.1590/1807-3107bor-2020.vol34.0002DOI Listing
February 2020

A systematic review on the mechanisms of malignant transformation of oral submucous fibrosis.

Eur J Cancer Prev 2020 Feb 7. Epub 2020 Feb 7.

Department of Oral and Maxillofacial Pathology and Microbiology, Manubhai Patel Dental College and Hospital, Vadodara, Gujarat, India.

Oral submucous fibrosis (OSMF), the most commonly encountered potentially premalignant oral epithelial lesion, is a chronic disorder associated with areca nut chewing. It has a relatively high potential for malignant transformation resulting into oral squamous cell carcinoma (OSCC), the most common oral malignancy with high mortality rate. Paymaster first described the malignant potential of OSMF in 1956, the rate of which had been estimated to be 7-13%. Read More

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http://dx.doi.org/10.1097/CEJ.0000000000000575DOI Listing
February 2020

[Relationship among areca nut, intracellular reactive oxygen species, and autophagy].

Hua Xi Kou Qiang Yi Xue Za Zhi 2020 Feb;38(1):80-85

The State Key Laboratory Breeding Base of Basic Science of Stomatology Hubei-MOST & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.

The relationship between areca nut as a primary carcinogen and oral cancer has been widely concerned. Areca can change the levels of reactive oxygen species (ROS) and autophagy in cells, and the levels of ROS and autophagy are closely related to the occurrence and development of tumors. This paper reviewed the relationships among areca nut, intracellular ROS, and autophagy. Read More

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http://dx.doi.org/10.7518/hxkq.2020.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184295PMC
February 2020

Diabetes mellitus and oral cancer/oral potentially malignant disorders: A systematic review and meta-analysis.

Oral Dis 2020 Jan 29. Epub 2020 Jan 29.

School of Dentistry, Biohealth Research Institute (IBS), University of Granada, Granada, Spain.

The objective was to evaluate current evidence on the prevalence and risk of oral cancer and potentially malignant oral disorders among patients with diabetes mellitus. We searched PubMed, Embase, Web of Science, and Scopus for observational studies published before November 2019. We evaluated the study quality using GRADE, QUIPS, and a specific method for systematic reviews addressing prevalence questions. Read More

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http://dx.doi.org/10.1111/odi.13289DOI Listing
January 2020

Expression of salivary miRNA 21 in Oral Submucous Fibrosis (OSMF): An observational study.

Microrna 2020 Jan 27. Epub 2020 Jan 27.

Sri krishna Sevashrama Hospital, Dental. India.

Objective: To observe the expression patterns of salivary mRNA 21 in different stages and grades of OSMF and also in habitual arecanut chewers without OSMF.

Subjects And Methods: The study consisted of a total of 185 samples, where 61 patients had chewing habits (chewing gutkha and other forms of arecanut) and had OSMF (Group 1). Sixty-one patients had chewing habits but did not have OSMF (Group 2), and 63 were normal healthy patients (control group) without any chewing habits (Group 3). Read More

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http://dx.doi.org/10.2174/2211536609666200127143749DOI Listing
January 2020

Oral potentially malignant disorders: A comprehensive review on clinical aspects and management.

Oral Oncol 2020 Jan 22;102:104550. Epub 2020 Jan 22.

King's College London, UK; WHO Collaborating Centre on Oral Cancer, UK. Electronic address:

Oral potentially malignant disorders (OPMDs) include a group of conditions that affect the oral mucosa with an increased risk of malignancy. During their evolution visible changes may be found in the colour or in the thickness of the oral mucosa and these changes can be detected during an oral examination. Their clinical presentations are diverse and their natural history is not well described. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.104550DOI Listing
January 2020

Inhibition of HIF1A-AS1 impedes the arecoline-induced migration activity of human oral mucosal fibroblasts.

J Formos Med Assoc 2020 Apr 18;119(4):879-883. Epub 2020 Jan 18.

Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan; School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan. Electronic address:

Long non-coding RNA hypoxia-inducible factor 1α-antisense RNA 1 (HIF1A-AS1) has been known to participate in various types of malignancies, but its role in the development of precancerous oral submucous fibrosis (OSF) has not been investigated. In the current study, we first observed the aberrant upregulation of HIF1A-AS1 in OSF tissues and fibrotic buccal mucosal fibroblasts (fBMFs) isolated from OSF specimens. Next, we demonstrated that administration of arecoline, a natural alkaloid that is found in areca nut, induced the elevation of HIF1A-AS1 in BMFs. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.12.014DOI Listing

Exophytic verrucous hyperplasia in oral submucous fibrosis: A single-center study.

J Oral Maxillofac Pathol 2019 Sep-Dec;23(3):393-399

Department of Oral Pathology, Nair Hospital Dental College, Mumbai, Maharashtra, India.

Introduction: The present study analyzed the occurrence of exophytic verrucous hyperplasia (EVH) in the background of oral submucous fibrosis (OSF), which presents clinically as a solitary verrucopapillary lesion (VPL) mimicking malignancy. We also aimed to obtain additional information on VELscope appearance and histopathological features of EVH.

Materials And Methods: The prevalence of EVH in OSF background was assessed from January 2014 to December 2018 using VELscope and histopathological examination. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_276_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948049PMC
January 2020

Evaluation of relationship between serum homocysteine and Vitamin B12 levels in oral submucous fibrosis patients using chemiluminescence immunoassay.

J Oral Maxillofac Pathol 2019 Sep-Dec;23(3):363-368

Department of Oral and Maxillofacial Pathology and Microbiology, Manubhai Patel Dental College and Hospital, Vadodara, Gujarat, India.

Background: Serum homocysteine (Hcy), a nonessential amino acid, is considered as a helpful indicator of vitamin status for its strong correlation with Vitamin B12. Although Hcy levels in oral submucous fibrosis (OSMF) have been studied, the relationship between Hcy and Vitamin B12 has not been studied yet. This study is the first one to compare and correlate the levels of serum Hcy and Vitamin B12 in OSMF patients. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_7_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948053PMC
January 2020

Oral submucous fibrosis: a contemporary narrative review with a proposed inter-professional approach for an early diagnosis and clinical management.

J Otolaryngol Head Neck Surg 2020 Jan 8;49(1). Epub 2020 Jan 8.

Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia.

Oral Submucous fibrosis (OSMF) has traditionally been described as "a chronic, insidious, scarring disease of the oral cavity, often with involvement of the pharynx and the upper esophagus". Millions of individuals are affected, especially in South and South East Asian countries. The main risk factor is areca nut chewing. Read More

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http://dx.doi.org/10.1186/s40463-020-0399-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951010PMC
January 2020