1,236 results match your criteria Oral Submucous Fibrosis


Impact of oral submucous fibrosis on oral health-related quality of life: a condition-specific OHRQoL-OSF instrument analysis.

Oral Dis 2018 Jun 21. Epub 2018 Jun 21.

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

Objective: Oral submucous fibrosis (OSF) could have a significant impact on daily life activities of affected individuals. The objective of this study was to investigate the impacts of OSF on oral health-related quality of life (OHRQoL).

Materials & Methods: A total of 206 clinically diagnosed OSF patients were recruited and subjected to the condition-specific OHRQoL-OSF instrument and global self-ratings of oral health and overall well-being. Read More

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June 2018
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Bibliometric analysis of 100 most cited articles on oral submucous fibrosis.

J Oral Pathol Med 2018 Jun 15. Epub 2018 Jun 15.

Department of Oral Pathology & Microbiology, Dr. D.Y. Patil Dental College & Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra State, India.

Background: Citation analysis reflects the scientific recognition and influential performance of an article in the scientific community. The objective of this study was to identify and characterize the 100 most cited articles on oral submucous fibrosis (OSF).

Methods: A list of 100 most cited articles related to OSF was retrieved from the Science Citation Index-Expanded tool of Scopus database in May 2018. Read More

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A comparative study to evaluate the efficacy of lycopene and curcumin in oral submucous fibrosis patients: A randomized clinical trial.

Indian J Dent Res 2018 May-Jun;29(3):303-312

Department of Oral Medicine and Radiology, Babu Banarasi Das College of Dental Sciences, BBD University, Lucknow, Uttar Pradesh, India.

Background: : Oral submucous fibrosis (OSMF) is a most prevalent potentially malignant disorder associated with betel quid chewing frequently observed in the Indian population. The present study conducted is much of a keen interest because there is much new information, both in the press and the medical literature, about the benefits of fresh fruits and vegetables and antioxidants (such as lycopene and curcumin) for both prevention and treatment of diseases. As clinicians, we often prescribe medications with significant adverse effects, and certainly, if armed with evidence to support using such antioxidants as safer therapeutic alternatives for treatment of OSMF. Read More

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Data regarding clinical evaluation of collagen membrane in oral mucosal defects due to oral submucous fibrosis and leukoplakia.

Data Brief 2018 Jun 22;18:607-612. Epub 2018 Mar 22.

Department of Dentistry, Government Taluk Head Quarters Hospital, Malappuram, India.

This data depicts the clinical evaluation of collagen membrane in oral mucosal defects due to oral submucous fibrosis and leukoplakia. This data comprised of 10 patients in the age group of 20-60 (3 male and 2 female patients with grade III and grade IV oral submucous fibrosis and 5 male patients with oral leukoplakia with a size of 3-5 cm in diameter). The parameters such as pain, swelling, allergy, biodegradability of collagen membrane, degree of re-epithelisation, degree of contracture, mouth opening and wound size were assessed after the placement of collagen membrane in oral mucosal defects. Read More

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June 2018
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miR-200b ameliorates myofibroblast transdifferentiation in precancerous oral submucous fibrosis through targeting ZEB2.

J Cell Mol Med 2018 Jun 12. Epub 2018 Jun 12.

School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.

Oral submucous fibrosis (OSF) is a progressive scarring disease. MicroRNA-200b (miR-200b) has been reported as a tumour suppressor, but its role in the precancerous OSF remains unknown. In this study, we investigated the impact of miR-200b on myofibroblastic differentiation activity. Read More

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Oral submucous fibrosis: A clinico-histopathological correlational study.

J Cancer Res Ther 2018 Apr-Jun;14(3):597-603

Department of Oral Medicine and Radiology, Shri Ramachandra Bhanj Dental College and Hospital, Cuttack, Odisha, India.

Aim Of The Study: The aim of this study was to correlate the clinical staging (clinical severity) with the histopathological staging (histopathological changes) of oral submucous fibrosis (OSF) patients, which would further assist the clinicians to formulate a definite treatment plan.

Materials And Methods: The study group consisted of 50 subjects who were clinically and histologically diagnosed as OSF. Detailed information was gathered in a pretested proforma with emphasis on the various addictions. Read More

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Conservative management of Oral Submucous Fibrosis in early and intermediate stage.

J Oral Biol Craniofac Res 2018 May-Aug;8(2):86-88. Epub 2017 Jun 19.

Unit of Oral & Maxillofacial Surgery, Oral Health Sciences Centre, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.

Aims & Objective: To evaluate the efficacy of combined intralesional injection of Hyaloronidase and Triamcinolone with third molar removal in early and intermediate stage (Stage II & III) of Oral Submucous Fibrosis (OSMF) for improvement in mouth opening and hypersensitivity to food.

Study Design: 48 patients in stage II & III OSMF were selected for the study. All the third molars were extracted in each patient followed by 6-8 doses of combined intralesional injection of Hyaloronidase and triamcinolone at 10 days interval targeting the fibrotic bands. Read More

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Significance of Serum Nitric Oxide and Superoxide Dismutase in Oral Submucous Fibrosis and Squamous Cell Carcinoma: A Comparative Study.

Contemp Clin Dent 2018 Apr-Jun;9(2):283-288

Department of Oral Medicine and Radiology, Tamil Nadu Government Dental College and Hospital, Affiliated to Tamil Nadu Dr. M.G.R. Medical University, Chennai, Tamil Nadu, India.

Introduction: This study aimed at comparative analysis of serum nitric oxide (NO) and superoxide dismutase (SOD) levels as therapeutic and prognostic biomarkers in patients with oral submucous fibrosis (OSMF) and squamous cell carcinoma (SCC).

Materials And Methods: Eighty-seven patients were grouped into Group I ( = 29, OSMF), Group II ( = 29, oral SCC), and Group III ( = 29, controls). Two ml of venous blood was collected from patients after overnight fast to avoid any dietary influence on the serum beta-carotene. Read More

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June 2018
2 Reads

Assessment of the quality of life and performance status in patients with oral submucous fibrosis in central India.

Clujul Med 2018 25;91(2):203-208. Epub 2018 Apr 25.

Oral Medicine and Radiology Department, KGMC Lucknow, India.

Background And Aims: Measuring quality of life in patients with oral submucous fibrosis is of utmost importance in assessing treatment outcomes. This study examined the impact of oral submucous fibrosis and its treatment on the quality of life and performance status of persons with oral submucous fibrosis.

Methods: Quality of life was measured in patients with oral submucous fibrosis using the European Organization for Research and Treatment of Cancer Quality of Life head and neck 35 Questionnaire (EORTC QLQ-C35); performance status was measured by Performance Status Scale for Head and Neck Cancer Patients (PSS-HN), at four points in time: baseline, one month, two months and three months after start of treatment. Read More

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Prevalence of oral potentially malignant disorders: A systematic review and meta-analysis.

J Oral Pathol Med 2018 May 8. Epub 2018 May 8.

Department of Pathology, Health Sciences Center, Federal University of Santa Catarina, Florianópolis, Brazil.

Oral potentially malignant disorders (OPMD) are chronic conditions, which have a higher risk of transformation to oral squamous cell carcinoma. The aim of this systematic review and meta-analysis was to answer the question: "What is the prevalence of oral potentially malignant disorders among adults?" Studies reporting the prevalence of these conditions (leukoplakia, erythroplakia, oral submucous fibrosis [OSMF], and actinic cheilitis) were selected, only studies in which a clinical assessment and histopathological confirmation were performed were included. Of the 5513 studies, 22 met the inclusion criteria for qualitative and quantitative analyses. Read More

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May 2018
2 Reads

Coalition of E-cadherin and vascular endothelial growth factor expression in predicting malignant transformation in common oral potentially malignant disorders.

J Oral Maxillofac Pathol 2018 Jan-Apr;22(1):40-47

Department of Oral and Maxillofacial Pathology, AECS Maaruti College of Dental Sciences and Research Centre, Bengaluru, Karnataka, India.

Background: Reduced E-cadherin expression and increased VEGF expression is known to be involved in tissue growth and transformation of Oral Potentially Malignant Disorders (OPMDs) and has been correlated with their differing histological grades in numerous studies.

Aim: To evaluate Immunohistochemical (IHC) expression of both E-cadherin and VEGF in predicting the malignant transformation potential of common OPMDs.

Materials And Methods: Ten cases each of Normal Oral mucosa (NOM), Mild Oral Epithelial Dysplasia (OED), Moderate OED, Severe OED, Oral Submucous Fibrosis, (OSMF) and Oral Squamous Cell Carcinoma (OSCC) were stained and evaluated for the expression of Ecadherin and VEGF. Read More

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May 2018
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Reply to: Comment on "TFM classification and staging of oral submucous fibrosis: A new proposal".

J Oral Pathol Med 2018 May 2. Epub 2018 May 2.

Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK.

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Evaluation of Collagen in Leukoplakia, Oral Submucous Fibrosis and Oral Squamous Cell Carcinomas Using Polarizing Microscopy and Immunohistochemistry

Asian Pac J Cancer Prev 2018 Apr 27;19(4):1075-1080. Epub 2018 Apr 27.

Department of Oral Pathology and Microbiology, Desh Bhagat Dental College and Hospital, Mandigobindgarh, Punjab, India.Email:

Objectives: Picrosirius red and MMP are capable of degrading extracellular matrix proteins, expressed in lesions such as squamous cell carcinomas. The present study was undertaken with an aim to analyze and compare changes in collagen using Picrosirius red staining under polarizing microscopy and immunohistochemical staining using anti MMP-13 in samples of oral leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma. Materials and Methods: A total of 70 slides were prepared and divided into 3 groups. Read More

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Mouth-opening device as a treatment modality in trismus patients with head and neck cancer and oral submucous fibrosis: a prospective study.

Clin Oral Investig 2018 Apr 26. Epub 2018 Apr 26.

Division of Oral and Maxillofacial Surgery, Tri-Service General Hospital, No.325, Cheng-Kung Rd., Sec.2, Neihu 114, Taipei, Taiwan, Republic of China.

Objectives: This study investigated the clinical effectiveness of intervention with an open-mouth exercise device designed to facilitate maximal interincisal opening (MIO) and improve quality of life in patients with head and neck (H&N) cancer and oral submucous fibrosis (OSF).

Materials And Methods: Sixty patients with H&N cancer, OSF, and trismus (MIO < 35 mm) participated in the functional rehabilitation program. An open-mouth exercise device intervention group and conventional group, each consisting of 20 patients, underwent a 12-week training and exercising program and follow-up. Read More

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April 2018
2 Reads

Endorsing cellular competitiveness in aberrant epithelium of oral submucous fibrosis progression: neighbourhood analysis of immunohistochemical attributes.

Histochem Cell Biol 2018 Apr 23. Epub 2018 Apr 23.

School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, 721 302, India.

Epithelial abnormality during the transformation of oral submucous fibrosis (OSF) into oral squamous cell carcinoma has been well studied and documented. However, the differential contribution of atrophy and hyperplasia for malignant potentiality of OSF is yet to be resolved. Existing diagnostic conjectures lack precise diagnostic attributes which may be effectively resolved by substantiation of specific molecular pathology signatures. Read More

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April 2018
2 Reads

Comment on "TFM classification and staging of oral submucous fibrosis: A new proposal".

J Oral Pathol Med 2018 Apr 23. Epub 2018 Apr 23.

Division of Oral Pathology, Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

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Clinical features and presentation of oral potentially malignant disorders.

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun 4;125(6):582-590. Epub 2018 Apr 4.

Emeritus Professor, King's College London, UK; WHO Collaborating Centre for Oral Cancer, London, UK. Electronic address:

Oral potentially malignant disorders (OPMDs) are conditions that precede the onset of invasive cancers of the oral cavity. The term embraces precancerous lesions and conditions referred to in earlier World Health Organization (WHO) definitions. Leukoplakia is the most common OPMD; erythroplakia, although rare, is more serious. Read More

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Butylidenephthalide abrogates the myofibroblasts activation and mesenchymal transdifferentiation in oral submucous fibrosis.

Environ Toxicol 2018 Jun 17;33(6):686-694. Epub 2018 Apr 17.

School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.

Oral submucous fibrosis (OSF) is a premalignant disorder in the oral cavity, and areca nut chewing habit has been implicated in the persistent activation of myofibroblasts and the subsequent fibrosis. Therefore, it is critical to ameliorate the excessive activities of myofibroblasts prior to the malignant transformation of OSF. In the current study, we evaluated the cytotoxicity of butylidenephthalide (BP), a major phthalide ingredient of Angelica sinensis, in fibrotic buccal mucosal fibroblasts (fBMFs) as well as various myofibroblast hallmarks, including the phenotypical characteristics and fibrosis-related markers. Read More

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June 2018
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Management update of potentially premalignant oral epithelial lesions.

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun 23;125(6):628-636. Epub 2018 Mar 23.

Department of Oral and Maxillofacial Surgery, North Memorial Medical Center, Minneapolis, MN, USA. Electronic address:

The term oral potentially malignant disorders, proposed at the World Health Organization workshop in 2005, has now been renamed potentially premalignant oral epithelial lesions (PPOELs). It is important to differentiate among PPOELs, which is a broad term to define a wide variety of clinical lesions, and oral epithelial dysplasia, which should be reserved specifically for lesions with biopsy-proven foci of dysplasia. PPOELs encompass lesions that include leukoplakia, erythroplakia, erythroleukoplakia, lichen planus, and oral submucous fibrosis. Read More

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June 2018
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Is matrix stiffness a cause for malignant transformation of oral submucous fibrosis?

J Oral Pathol Med 2018 Apr 14. Epub 2018 Apr 14.

Department of Oral Pathology & Microbiology, Yerala Dental College and Hospital, Kharghar, Mumbai, India.

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Immunohistochemical expression of polo-like kinase 1 in oral squamous cell carcinoma and oral submucous fibrosis.

Indian J Dent Res 2018 Mar-Apr;29(2):171-175

Department of Pathology, Tagore Medical College and Hospital, Chennai, Tamil Nadu, India.

Context: Polo-like kinase 1 (PLK1) is a critical molecule in the proliferation of several human cancers. Overexpression of PLK1 has been correlated with cancer cell proliferation and lower overall survival rates. Although PLK1 has been studied in various tumors, information regarding its expression in oral cancer and precancer is limited. Read More

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"Introducing Modified Dakkak and Bennett Grading System for Indian Food in Oral Submucous Fibrosis": A Dharwad Study.

J Diet Suppl 2018 Apr 6:1-8. Epub 2018 Apr 6.

a Department of Oral Medicine & Radiology , Century International Institute of Dental Science & Research Centre , Poinachi, Kasargod , Kerala , India.

Oral submucous fibrosis (OSMF) is one of the "diseases of civilization" because of the large differences in prevalence among races, geographic areas, and individuals at different socioeconomic levels. It is a premalignant condition strongly associated with the habit of chewing areca nuts. This study is to compare the scoring system in relation to the burning sensation of mouth and dysphagia using the visual analog scale (VAS) and Dakkak and Bennett grading system for Indian food, respectively, in OSMF patients. Read More

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April 2018
3 Reads

Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology.

Authors:
Susan Müller

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun 1;125(6):591-602. Epub 2018 Mar 1.

Emory University School of Medicine, Atlanta Oral Pathology, Decatur, GA, USA. Electronic address:

The term oral potentially malignant disorders (OPMDs) describes a recognizable group of mucosal diseases that have a risk of progressing to squamous cell carcinoma. Oral leukoplakia, the most common OPMD, has a 1% prevalence and reported malignant transformation rates of 2% to 5%. Other OPMDs include erythroplakia, erythroleukoplakia, submucous fibrosis, lesions of reverse smokers, and inherited genetic disorders, such as Fanconi anemia. Read More

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Quality of Life-related "Patient-reported Outcome Measures" in Oral Submucous Fibrosis Patients.

J Contemp Dent Pract 2018 Mar 1;19(3):331-338. Epub 2018 Mar 1.

Division of Oral Pathology, Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University Jazan, Kingdom of Saudi Arabia.

Aim: The aim of this study was to explore the patients' perspectives about the impact of oral submucous fibrosis (OSF) on life quality.

Materials And Methods: Thirty clinically diagnosed OSF patients with a wide degree of disease severity and diverse range of sociodemographic profile were included in this study. Fourteen participants were interviewed and four focus group discussions were conducted in nonclinical settings. Read More

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Development and validation of oral health-related quality of life measure in oral submucous fibrosis.

Oral Dis 2018 Mar 23. Epub 2018 Mar 23.

Department of Oral Pathology & Microbiology, Dr. D.Y. Patil Dental College & Hospital, Dr. D.Y. PatilVidyapeeth, Pune, Maharashtra, India.

Objective: The aim of this study was to develop and assess the validity and reliability of disease-specific oral health-related quality of life (OHRQoL) instrument for oral submucous fibrosis (OSF).

Materials And Methods: Items for the OHRQoL-OSF were generated from personal interviews and focus group discussions, the existing questionnaires, reviews of literature and inputs from expert's panel. Item reduction was performed by clinical impact method followed by pretesting of the developed questionnaire. Read More

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March 2018
3 Reads

Retrograde intubation through nasal route in patients with limited mouth opening undergoing oral and maxillofacial surgery.

J Oral Biol Craniofac Res 2018 Jan-Apr;8(1):30-34. Epub 2017 Aug 25.

Department of anesthesia, Sri Sai College of Dental Surgery, Vikarabad, Telangana, India.

Background: Patients with limited mouth opening (LMO) often associated with difficult intubation. Retrograde intubation is an alternative technique of establishing definitive airway in these patients when blind nasal intubation fails and fiberoptic bronchoscope is not available. We tested the retrograde intubation through nasal route in patients with LMO less than 2 cm. Read More

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August 2017
7 Reads

Differential expression of organic cation transporter 3 in oral submucous fibrosis-associated buccal squamous cell carcinoma.

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Mar 6. Epub 2018 Mar 6.

Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Objective: The aim of this study was to examine the expression of organic cation transporter 3 (OCT3) in patients with oral submucous fibrosis (OSF)-associated buccal squamous cell carcinoma (BSCC) and to explore its clinical significance.

Study Design: A total of 56 tissue specimens were collected from patients, among which there were 13 specimens with normal buccal mucosa (NBM), 13 with oral submucous fibrosis (OSF), 10 with OSF-associated BSCC (BSCC-OSF), 10 with well-differentiated BSCC (BSCC-I), and 10 with poorly to moderately differentiated BSCC (BSCC-II+III), based on pathologic examination. The expression of OCT3 was detected by using immunohistochemistry and real-time quantitative reverse transcription polymerase chain reaction. Read More

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March 2018
7 Reads

Sonographic imaging of fibrosis of oral mucosa and its correlation with clinical staging in oral submucous fibrosis.

J Cancer Res Ther 2018 Jan-Mar;14(2):394-397

Department of Oral Medicine and Radiology, Kamineni Institute of Dental Sciences, Nalgonda, Telangana, India.

Background And Objectives: To evaluate the efficacy of ultrasonography (USG) as a noninvasive tool in assessing the severity of oral submucous fibrosis (OSMF) by measuring the submucosal thickness and also to correlate the sonographic changes with clinical staging.

Materials And Methods: The submucosal thickness of the upper and lower labial mucosa, anterior and posterior portions of the right and left buccal mucosa were measured using ultrasound in 64 patients comprising of 32 OSMF patients and 32 controls. Among the controls, 16 were with a habit of chewing gutkha and 16 were without any habit history. Read More

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Analysis of images for detection of oral epithelial dysplasia: A review.

Oral Oncol 2018 Mar 10;78:8-15. Epub 2018 Jan 10.

Centre for Biomaterials, Cellular, and Molecular Theranostics, VIT University, Vellore 632014, India; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.

This paper provides a review of various image analysis approaches that have been previously used for recognition of dysplasia in images of the epithelium of the oral cavity. This domain has become especially admissible with the uncovering of the importance of image analysis which can probably be an aid to subjective diagnosis by histopathologists. Oral malignancy is a rampant form of cancer found among people of the Indian subcontinent due to various deleterious habits like consumption of tobacco, areca nut, betel leaf etc. Read More

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March 2018
12 Reads

Oral Submucous Fibrosis as an Overhealing Wound: Implications in Malignant Transformation.

Recent Pat Anticancer Drug Discov 2018 Feb 26. Epub 2018 Feb 26.

Department of Oral Pathology, Manipal College of Dental Sciences, Manipal University, Manipal - 576104. India.

Background: Oral submucous fibrosis is an oral potentially malignant disorder with high incidence of malignant transformation and rising global prevalence. However, the genesis of oral submucous fibrosis is still unclear despite superfluity of literature. In the background of ineffective treatment, it is necessary to decode its onset and progression before designing customized treatment regimens. Read More

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February 2018
4 Reads

Myofibroblasts in oral potentially malignant disorders: Is it related to malignant transformation?

Authors:
R D Coletta T Salo

Oral Dis 2018 Mar;24(1-2):84-88

Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.

In oral cancer, acquisition of α-smooth muscle actin (α-SMA)-positive fibroblasts, known as myofibroblasts or carcinoma-associated fibroblasts (CAF), is an important event for progression and metastasis. However, the contribution of myofibroblasts in oral potentially malignant disorders (OPMD) remains controversial. This systematic review provides evidence that immunodetection of myofibroblasts may identify oral submucous fibrosis (OSMF) with high risk of malignant transformation, but does not represent an auxiliary tool to predict the malignant potential of leukoplakia and erythroplakia, the most common OPMD. Read More

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Dysplastic features relevant to malignant transformation in atrophic epithelium of oral submucous fibrosis: A preliminary study.

J Oral Pathol Med 2018 Apr 12;47(4):410-416. Epub 2018 Mar 12.

Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, India.

Background: The grading of oral epithelial dysplasia (OED) is not applicable to oral submucous fibrosis (OSMF) cases due to the presence of atrophic epithelium. The mucosal margins associated with resected OSCC specimens are often closely related to transformed cells. In this study, we compared the histomorphological alterations (dysplastic features) in the atrophic epithelium of OSMF patients with the mucosal margins of OSCC associated with OSMF (OSCC-OSMF). Read More

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April 2018
2 Reads

TFM classification and staging of oral submucous fibrosis: A new proposal.

J Oral Pathol Med 2018 May 24;47(5):539. Epub 2018 Mar 24.

Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Cosham, UK.

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Comment on the article "TFM classification and staging of oral submucous fibrosis: A new proposal".

Authors:
Arpita Rai

J Oral Pathol Med 2018 May 25;47(5):538. Epub 2018 Mar 25.

Oral Medicine and Radiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India.

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Experimental study on TGF-β1-mediated CD147 expression in oral submucous fibrosis.

Oral Dis 2018 Feb 19. Epub 2018 Feb 19.

Centre of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Objective: Although previous evidence indicates that CD147 is closely involved in the progression of organ fibrosis and various signaling pathways have been proven to regulate its expression, the role of CD147 in oral submucous fibrosis (OSF) remains largely unknown.

Methods: In this study, we investigated the expression of CD147 and transforming growth factor β1 (TGF-β1) in human samples of an OSF tissue array by immunohistopathology. Pearson's correlation analysis was conducted to explore the correlation between CD147 and TGF-β1. Read More

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February 2018

New research directions for areca nut/betel quid and oral submucous fibrosis for holistic prevention and treatment.

Oral Oncol 2018 Mar 8;78:218-219. Epub 2018 Feb 8.

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

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March 2018
3 Reads

Malignant transformation of Taiwanese patients with oral leukoplakia: A nationwide population-based retrospective cohort study.

J Formos Med Assoc 2018 May 7;117(5):374-380. Epub 2018 Feb 7.

School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address:

Background/purpose: Oral leukoplakia (OL) is one of the clinically diagnosed oral potentially malignant disorders (OPMDs) with an increased risk of oral cancer development. In this study, we investigated the malignant transformation of OL in Taiwanese population.

Methods: A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. Read More

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May 2018
3 Reads

Angiogenesis and Fibrogenesis in Oral Submucous Fibrosis: A Viewpoint.

J Contemp Dent Pract 2018 Feb 1;19(2):242-245. Epub 2018 Feb 1.

Division of Oral Pathology, Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University Jazan, Kingdom of Saudi Arabia.

Oral submucous fibrosis (OSF) is characterized by excessive fibrosis of submucosa. The degree of vascularity in OSF has always been a matter of debate. Angiogenesis is the key mechanism involved in regeneration and repair. Read More

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February 2018
1 Read

Podoplanin expression in oral potentially malignant disorders and oral squamous cell carcinoma.

J Clin Exp Dent 2017 Dec 1;9(12):e1418-e1424. Epub 2017 Dec 1.

Associate Professor, Department of Oral and Maxillofacial Pathology PMS College of Dental Science and Research, Thiruvananthapuram, Kerala, India.

Background: Podoplanin is a type I transmembrane sialomucin-like glycoprotein that is specifically expressed in lymphatic endothelial cells. Studies have shown that assessment of podoplanin expression in the epithelial cells can be used to predict the malignant transformation of potentially malignant disorders and the metastatic tendency of primary head and neck squamous cell carcinoma. The aim of our study was to compare the expression of podoplanin in oral leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma with that in normal buccal mucosa by immunohistochemical methods. Read More

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December 2017
2 Reads

TFM classification and staging of oral submucous fibrosis: A new proposal.

J Oral Pathol Med 2018 Apr 2;47(4):403-409. Epub 2018 Mar 2.

Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK.

Background: We have evaluated the rationale of existing grading and staging schemes of oral submucous fibrosis (OSMF) based on how they are categorized. A novel classification and staging scheme is proposed.

Methods: A total of 300 OSMF patients were evaluated for agreement between functional, clinical, and histopathological staging. Read More

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April 2018
7 Reads

Oral potentially malignant disorders: risk of progression to malignancy.

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun 29;125(6):612-627. Epub 2017 Dec 29.

UWA Dental School, The University of Western Australia, Nedlands, Australia.

Oral potentially malignant disorders (OPMDs) have a statistically increased risk of progressing to cancer, but the risk varies according to a range of patient- or lesion-related factors. It is difficult to predict the risk of progression in any individual patient, and the clinician must make a judgment based on assessment of each case. The most commonly encountered OPMD is leukoplakia, but others, including lichen planus, oral submucous fibrosis, and erythroplakia, may also be seen. Read More

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Myofibroblasts: Master of disguise.

J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):462-463

Department of Oral and Maxillofacial Pathology, St. Joseph Dental College, Eluru, Andhra Pradesh, India.

Myofibroblasts are the unique population of smooth muscle-like fibroblasts. These cells have a role in growth factors secretion, matrix deposition and degradation. Thereby, myofibroblast contributes in both human physiology and pathology. Read More

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February 2018

Evaluation of role of trace elements in oral submucous fibrosis patients: A study on Gujarati population.

J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):455

Department of Oral Medicine and Radiology, Ahmedabad Dental College and Hospital, Ahmedabad, Gujarat, India.

Introduction: Oral submucous fibrosis (OSMF), a precancerous condition, is highly prevalent in the Indian subcontinent. Among many trace elements, copper and iron are required for the functioning of numerous enzymes. The biochemical alterations of these trace elements in the serum of patients with premalignant conditions can help in determining the staging of the disease, its appropriate treatment and as an indicator for prognosis. Read More

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February 2018

Quantitative and qualitative assessment of argyrophilic nucleolar organizer regions in normal, premalignant and malignant oral lesions.

J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):360-366

Department of Oral Pathology, College of Dental Sciences and Research Bopal Dental College, Ahmedabad, Gujarat, India.

Aim: The aim of the study was to assess the cell proliferation and biologic aggressiveness of the lesions by evaluating the significance of number and dispersal pattern of Argyrophillic Nucleolar organizing Regions (AgNORs) using silver colloid technique in normal mucosa, premalignant and malignant lesions.

Settings And Design: In-vitro study, lab setting.

Methods And Material: The study sample consisted of five groups each with a sample size of 10 and a control group. Read More

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February 2018

Oral submucous fibrosis: An update.

J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):330-331

Department of Oral and Maxillofacial Pathology, V.S. Dental College and Hospital, Bengaluru, Karnataka, India.

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February 2018

Oral submucous fibrosis: Newer proposed classification with critical updates in pathogenesis and management strategies.

Natl J Maxillofac Surg 2017 Jul-Dec;8(2):89-94

Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, India.

Oral submucous fibrosis (OSMF) is an oral precancerous condition characterized by inflammation and progressive fibrosis of the submucosal tissues resulting in marked rigidity and trismus. OSMF still remains a dilemma to the clinicians due to elusive pathogenesis and less well-defined classification systems. Over the years, many classification systems have been documented in medical literature based on clinical, histopathological, or functional aspects. Read More

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February 2018
3 Reads

Risk analysis of malignant potential of oral verrucous hyperplasia: A follow-up study of 269 patients and copy number variation analysis.

Head Neck 2018 May 29;40(5):1046-1056. Epub 2018 Jan 29.

Graduate Institute of Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.

Background: Oral verrucous hyperplasia is commonly observed in the oral cavity of betel quid chewers and is a potential malignant disorder. However, the prognostic factors and genetic alterations of oral verrucous hyperplasia are unclear.

Methods: We calculate the survival rate and prognostic factors using a Kaplan-Meier analysis and Cox proportional hazards regression model. Read More

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May 2018
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Versatility of Modified Nasolabial Flap in Oral and Maxillofacial Surgery.

Arch Craniofac Surg 2017 Dec 23;18(4):243-248. Epub 2017 Dec 23.

Department of Oral & Maxillofacial Surgery, Sri Aurobindo College of Dentistry, Indore, India.

Background: To evaluate the versatility and reach of modified nasolabial flap used in reconstruction of defects created in and around the oral cavity.

Methods: A total number of 20 cases were selected. Out of which 13 were males and 7 females. Read More

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December 2017
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Hinokitiol ablates myofibroblast activation in precancerous oral submucous fibrosis by targeting Snail.

Environ Toxicol 2018 Apr 12;33(4):454-462. Epub 2018 Jan 12.

School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.

Oral submucous fibrosis (OSF) is a precancerous condition with symptoms of limited mouth opening and areca nut chewing habit has been implicated in its pathogenesis. Hinokitiol, a natural tropolone derived from Chamacyparis taiwanensis, has been reported to improve oral lichen planus and inhibit various cancer cells. Here, we showed that hinokitiol reduced the myofibroblast activities in fBMFs and prevented the arecoline-induced transdifferentiation. Read More

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April 2018
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