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    1129 results match your criteria Oral Submucous Fibrosis

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    Determination of role of ceruloplasmin in oral potentially malignant disorders and oral malignancy - A cross sectional study.
    Oral Dis 2017 May 17. Epub 2017 May 17.
    Department of Oral Medicine and Radiology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth University, Piparia, Vadodara, Gujarat, India.
    Objectives: In the process of carcinogenesis, lipid peroxidation and increased oxidative stress leads to changes in certain antioxidants. The present study was aimed to assess and co-relate serum levels of ceruloplasmin in oral premalignancies and oral cancer so as to gauge its possible association with the process of carcinogenesis and to determine its role as tumor marker.

    Material And Methods: The total of 300 participants, were equally divided in six study groups i. Read More

    Paediatric oral submucous fibrosis - The neglected pre-malignancy of childhood.
    Int J Pediatr Otorhinolaryngol 2017 Jun 28;97:55-60. Epub 2017 Mar 28.
    Jaypee Hospital, Noida 201301, India.
    Oral submucous fibrosis in children is one of the devastating consequences of arecanut addiction in children. Arecanut is the fourth commonest psychoactive agents used worldwide. However, regrettably, unlike other addictions like tobacco and alcohol, its use in children has become socially acceptable atleast in a few countries. Read More

    Photodynamic treatment outcomes of potentially-malignant lesions and malignancies of the head and neck region: A systematic review.
    J Investig Clin Dent 2017 May 8. Epub 2017 May 8.
    Department of Conservative and Endodontics, HSRS Dental College and Hospital, Hingoli, Maharashtra, India.
    Aim: The aim of the present study was to systematically review the efficacy of photodynamic therapy (PDT) in the management of oral potentially-malignant disorders (PMDS) and head and neck squamous cell carcinoma (HNSCC).

    Methods: From 1985 to 2015, PubMed/Medline, Google Scholar, EMBASE, and ISI Web of Knowledge were searched using different combinations of the following key words: PDT, oral precancer, leukoplakia, erythroplakia, erythroleukoplakia, verrucous hyperplasia, oral submucous fibrosis, and HNSCC. Review articles, experimental studies, case reports, commentaries, letters to the editor, unpublished articles, and articles published in languages other than English were excluded. Read More

    Oral submucous fibrosis: A quantitative assessment of serum malondialdehyde, superoxide dismutase and correlation with clinical staging.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):41-45
    Department of Oral Pathology, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
    Background: Oral submucous fibrosis (OSMF) is a progressive disorder affecting the oral mucosa. OSMF predominantly seen in South-east Asian countries. There are some biochemicals parameters which are modify in oral submucous fibrosis; this alteration can be used as a tool for diseases progress and avert malignant transformation. Read More

    Redefining epithelial characterization in oral submucous fibrosis using morphometric analysis.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):36-40
    Department of Oral and Maxillofacial Pathology and Microbiology, ITS Centre for Dental Studies and Research, Ghaziabad, Uttar Pradesh, India.
    Background: Oral submucous fibrosis (OSMF) is a chronic oral mucosal disease characterized by progressive deposition of collagen in subepithelial connective tissue and epithelial atrophy. The present study was conducted to evaluate the changes in epithelial thickness and cellular and nuclear morphometric characteristics of parabasal and spinous compartments of the epithelium in various stages of OSMF in comparison to normal epithelium.

    Materials And Methods: Sample included 30 cases of OSMF of various stages and five cases of normal buccal mucosa. Read More

    Estimation of hemoglobin, serum iron, total iron-binding capacity and serum ferritin levels in oral submucous fibrosis: A clinicopathological study.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):30-35
    Department of Oral and Maxillofacial Pathology, Mamata Dental College and Hospital, Khammam, Telangana, India.
    Introduction: Oral submucous fibrosis (OSMF) is also considered as an Asian version of sideropenic dysphagia, wherein chronic iron deficiency leads to mucosal susceptibility to irritants, such as chillies and areca nut products. Hemoglobin (Hb) levels, in particular, serum iron levels, are considered as biochemical indicators for nutritional assessment. Serum iron content can thus be a predictor for the progression of the condition, and there appears to be an association between serum iron content and oral carcinogenesis. Read More

    "Clinicobiochemical evaluation of turmeric with black pepper and Nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study"-a commentary.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jun 16;123(6):737. Epub 2017 Mar 16.
    Assistant Professor, Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, India.

    Activation of transforming growth factor-β1 by thrombin via integrins αvβ1, αvβ3, and αvβ5 in buccal fibroblasts: Suppression by epigallocatechin-3-gallate.
    Head Neck 2017 May 2. Epub 2017 May 2.
    School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan.
    Background: Transforming growth factor-beta (TGF-β) plays a central role in the pathogenesis of oral submucous fibrosis (OSF). Thrombin is a key player in tissue repair, inflammation, and fibrosis after injury.

    Methods: Effects of thrombin on activated-TGF-β1 levels, Smad3 phosphorylation, and connective tissue growth factor (CTGF/CCN2) synthesis in primary human buccal mucosal fibroblasts (BMFs) were assessed by enzyme-linked immunosorbent assay or Western blot analysis. Read More

    Reply to: Details of the participants and medical intervention used in the study evaluating the effect of a mouth exercising device on burning sensation in oral submucous fibrosis.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jun 21;123(6):735-737. Epub 2017 Feb 21.
    Lecturer, Department of Orthodontics, Faculty of Dentistry, MAHSA University, Kuala Lumpur, Malaysia.

    Qualitative analysis of the impact of Oral Potentially Malignant Disorders on daily life activities.
    PLoS One 2017 14;12(4):e0175531. Epub 2017 Apr 14.
    Menzies Health Institute Queensland, Griffith University, Queensland, Australia.
    Objective: To evaluate the impact of Oral Potentially Malignant Disorders (OPMD) on daily life activities.

    Materials And Methods: Patients diagnosed with Oral Leukoplakia, Oral submucous fibrosis and Oral Lichen Planus attending the Oral Medicine clinic of Panineeya Institute of Dental Sciences & Research Centre, Hyderabad, India were invited to participate. Eighteen interviews and three focus groups were conducted in a non-clinical setting. Read More

    Genetic changes in oral premalignant lesion, condition, and oral squamous cell carcinoma - A study based on inhibition of G2M phase by colchicines.
    Indian J Dent Res 2017 Jan-Feb;28(1):55-58
    Department of Oral Medicine and Radiology, Farooquia Dental College and Hospital, Mysore, Karnataka, India.
    Aims: To assess the percentage of cell arrested in G2M phase by colchicine in the early detection and prognosis of oral cancer, by comparison of oral squamous cell with leukoplakia and oral submucous fibrosis (OSMF) using flow cytometry analysis.

    Materials And Methods: Biopsy samples 5 each of clinically diagnosed and histopathologically confirmed case of leukoplakia, OSMF, and squamous cell carcinoma (SCC) are included in the study.

    Results: Colchicines significantly inhibited the growth of oral SCC-9 cell line by arresting G2M phase of the cell cycle (94. Read More

    Response to "Commentary on 'Clinicobiochemical evaluation of turmeric with black pepper and nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study'".
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jun 18;123(6):737-738. Epub 2017 Mar 18.
    Department of Oral Medicine and Radiology, College of Dental Sciences, Davangere, Karnataka, India.

    Oral submucous fibrosis: An update on pathophysiology of malignant transformation.
    J Oral Pathol Med 2017 Apr 9. Epub 2017 Apr 9.
    Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Cosham, Portsmouth, UK.
    Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7. Read More

    Oral submucous fibrosis: An update on current theories of pathogenesis.
    J Oral Pathol Med 2017 Apr 9. Epub 2017 Apr 9.
    Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Cosham, Portsmouth, UK.
    Over the last 40 years, many theories linking oral submucous fibrosis (OSMF) to various risk factors have been proposed. Spicy, pungent foods and irritants such as supari (areca nut), paan (betel leaves), tobacco (through chewing or smoking)-the common Asian habits of chewing the aforementioned agents-have all been incriminated as causative agents. Systemic factors such as nutritional deficiency, genetic predisposition and autoimmunity have also been proposed in the pathogenesis of OSMF. Read More

    Current protocols in the management of oral submucous fibrosis: An update.
    J Oral Pathol Med 2017 Apr 9. Epub 2017 Apr 9.
    Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Cosham, Portsmouth, UK.
    Oral submucous fibrosis (OSMF) is a debilitating condition of oral cavity which has significant potential for malignant transformation. In spite of over 20 years of research, the pathogenesis of the condition is still obscure and no single management modality is effective. Many OSMF treatment protocols have been proposed to alleviate the signs and symptoms of the disorder and there is overwhelming evidence that as areca nut is primary cause, stopping its use may have a considerable effect on symptoms rather than reversing pre-existing fibrosis. Read More

    Changes in prevalence of precancerous oral submucous fibrosis from 1996 to 2013 in Taiwan: A nationwide population-based retrospective study.
    J Formos Med Assoc 2017 Apr 5. Epub 2017 Apr 5.
    Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan; School of Dentistry, Chung Shan Medical University, Taichung, Taiwan. Electronic address:
    Background/purpose: Oral submucous fibrosis (OSF) has been regarded as a precancerous condition. Research examining the prevalence of OSF could be the first step in preventing or reducing malignant transformation. In this study, we probed a nationwide registered database to assess the prevalence, gender distribution, age, income, and urbanization status of OSF patients in Taiwan. Read More

    Estimation of Serum Protein in Oral Potentially Malignant Disorders and Oral Malignancy - A Cross-Sectional Study.
    J Clin Diagn Res 2017 Feb 1;11(2):ZC17-ZC19. Epub 2017 Feb 1.
    Reader, Department of Oral Medicine and Radiology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth University , Piparia, Vadodara, Gujarat, India .
    Introduction: In carcinogenesis, increased oxidative stress and weakened antioxidant defense produces damage to the macromolecules like proteins. Thus, protein can act as potential biomarker in oral premalignant and malignant lesions.

    Aim: To determine and compare the levels of serum proteins in Oral Submucuous Fibrosis (OSMF), Oral Leukoplakia (OL), Nicotina Stomatitis (NS), Oral Malignancy (OM) and Healthy Controls (HC). Read More

    Regulation of hypoxia-inducible factor-1α in human buccal mucosal fibroblasts stimulated with arecoline.
    J Formos Med Assoc 2017 Jun 30;116(6):484-487. Epub 2017 Mar 30.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address:
    Hypoxia-inducible factor (HIF)-1α is consistently and dramatically upregulated in a variety of fibrotic diseases. The aim of this study was to compare HIF-1α expression from fibroblasts derived from human normal buccal mucosa and oral submucous fibrosis (OSF) specimens and further to explore the potential mechanisms that may lead to induce HIF-1α expression. OSF buccal mucosal fibroblasts (BMFs) demonstrated significantly higher HIF-1α mRNA expression than normal BMFs (p<0. Read More

    Verrucoid Variant of Invasive Squamous Cell Carcinoma in Oral Submucous Fibrosis: A Clinicopathological Challenge.
    Cureus 2016 Nov 4;8(11):e862. Epub 2016 Nov 4.
    Department of Oral Pathology, Thai Moogambigai Dental College and Hospital.
    Verrucous carcinoma (VC) is an exophytic, low-grade, well-differentiated variant of squamous cell carcinoma. It is described as a lesion appearing in the sixth or seventh decade of life that has minimal aggressive potential and, in long-standing cases, has been shown to transform into squamous cell carcinoma. Oral submucous fibrosis (OSMF) is a potentially malignant disorder, and about one-third of the affected population develop oral squamous cell carcinoma. Read More

    Micronutrients and Their Role in Oral Cancer: A Review.
    West Indian Med J 2016 Mar 15;65(2):383-388. Epub 2016 Mar 15.
    Department of Oral Medicine and Radiology, AB Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, India.
    Cancer is one of the leading causes of death across the world. Oral cancer is the sixth most common type of cancer in the world. The incidence of oral cancer increases with the increase in the consumption of carcinogens such as tobacco and alcohol as seen in south and southeast Asia. Read More

    Complications in the use of bilateral inferiorly based nasolabial flaps for advanced oral submucous fibrosis.
    Natl J Maxillofac Surg 2016 Jul-Dec;7(2):115-121
    Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Deemed University, Dental College and Hospital, Pune, Maharashtra, India.
    Surgical management of advanced oral submucous fibrosis (OSMF) using bilateral inferiorly based nasolabial flaps is becoming increasingly popular. However no comprehensive analysis of delayed complications using this technique is available in the literature. The authors have conducted a retrospective study to examine the delayed complications of bilateral inferiorly based nasolabial flaps used in advanced oral submucous fibrosis at their institute along with a detailed review of literature on the subject. Read More

    [Epidemiological investigation of chewing fresh or dried betel nut and oral mucosal disease].
    Hua Xi Kou Qiang Yi Xue Za Zhi 2016 Aug;34(4):391-394
    Dept. of Oral Mucosa Diseases, Hainan Provincial Stomatology Center, Affiliate Haikou Hospital of Xiangya Medical School, Central South University, Haikou 570208, China.
    Objective: This study was conducted to investigate the effect of chewing fresh or dried betel nut on the inci-dence and canceration of oral mucosa disease in Haikou City in Hainan Province.

    Methods: Through a survey questionnaire, clinical examination, and regular follow-up, we collected clinical data from 1 722 cases and divided them into two groups, among which 704 of the afflicted people chew dried betel nut, whereas the other 1 018 chew fresh betel nut. The data were 
statistically analyzed using different variables which included age, number, time of onset of the disease, and the cancerous condition associated with common oral mucosa disease, including oral submucous fibrosis (OSF), oral leukoplakia (OLK), and oral Lichen planus (OLP). Read More

    Pan masala habits and risk of oral precancer: A cross-sectional survey in 0.45 million people of North India.
    J Oral Biol Craniofac Res 2017 Jan-Apr;7(1):13-18. Epub 2016 Dec 29.
    Roseman University of Health Sciences, Henderson, NV, United States.
    Objectives: This cross-sectional community based study was conducted to estimate the prevalence of consumption habits for non tobacco pan masala (ASU) and the risk of developing oral precancer in North India.

    Methods: This study was conducted in the old town of Lucknow city in the state of Uttar Pradesh in India. Subjects residing for more than 6 months and aged 15 years or above, were enrolled in the study after their informed consent. Read More

    Analysis of silver binding nucleolar organizer regions in exfoliative cytology smears of potentially malignant and malignant oral lesions.
    Biotech Histochem 2017 1;92(2):115-121. Epub 2017 Mar 1.
    e Department of Oral Medicine and Radiology , Pacific Dental College and Hospital , Udaipur , Rajasthan , India.
    Nucleolar organizer regions are nucleolar components that contain proteins that are stained selectively by silver methods; they can be identified as black dots throughout the nucleolus and are known as silver binding nucleolar organizer regions (AgNOR). The number of AgNOR is related to the cell cycle and the proliferative activity of the cells. We investigated AgNOR using exfoliative cytology smears of potentially malignant oral lesions. Read More

    Malignant transformation of oral submucous fibrosis in Taiwan: A nationwide population-based retrospective cohort study.
    J Oral Pathol Med 2017 Mar 14. Epub 2017 Mar 14.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
    Background: Oral submucous fibrosis (OSF) is one of the well-recognized oral potentially malignant disorders. In this study, we investigated the malignant transformation of OSF in a Taiwanese population.

    Methods: A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. Read More

    Smokeless tobacco (paan and gutkha) consumption, prevalence, and contribution to oral cancer.
    Epidemiol Health 2017 9;39:e2017009. Epub 2017 Mar 9.
    International Campus, Tehran University of Medical Sciences (IC-TUMS), Tehran, Iran.
    Smokeless tobacco consumption, which is widespread throughout the world, leads to oral submucous fibrosis (OSMF), which is a long-lasting and devastating condition of the oral cavity with the potential for malignancy. In this review, we mainly focus on the consumption of smokeless tobacco, such as paan and gutkha, and the role of these substances in the induction of OSMF and ultimately oral cancer. The list of articles to be examined was established using citation discovery tools provided by PubMed, Scopus, and Google Scholar. Read More

    Evaluation of Efficacy of Intraligamentary Injection Technique for Extraction of Mandibular Teeth-A Prospective Study.
    J Clin Diagn Res 2017 Jan 1;11(1):ZC110-ZC113. Epub 2017 Jan 1.
    Associate Professor, Department of Oral and Maxillofacial Surgery, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth , Pune, Maharashtra, India .
    Introduction: Fear of dental pain is one of the most common reasons for delaying dental treatment. Local Anaesthesia (LA) is the most commonly employed technique of achieving pain control in dentistry. Pterygomandibular Nerve Block (PNB), for achieving mandibular anaesthesia has been the traditional technique used and is associated with a few set of complications which include pain, nerve injury, trismus, and rarely facial nerve palsy, and sustained soft tissue anaesthesia. Read More

    Environmental heavy metal as a potential risk factor for the progression of oral potentially malignant disorders in central Taiwan.
    Cancer Epidemiol 2017 Apr 2;47:118-124. Epub 2017 Mar 2.
    Graduate Institute of Statistics and Information Science, National Changhua University of Education, Changhua 500, Taiwan. Electronic address:
    Objective: Oral cancer (OC) is a leading cause of death from cancer in men between the ages of 25 and 44 years in Taiwan. The overall 5-year survival rates for the four OC stages (I-IV) in Taiwan are approximately 70%, 30%, 20%, and 10%, respectively, indicating the importance of the early diagnosis of oral potentially malignant disorders (OPMDs). Previous studies indicated an association between the OC incidence and certain environmental heavy metal concentrations. Read More

    Knowledge, Attitude, and Practice of Women in Slums of Pimpri, Chinchwad, Pune, Maharashtra, India, regarding Usage of Mishri.
    J Contemp Dent Pract 2017 Mar 1;18(3):218-221. Epub 2017 Mar 1.
    Department of Public Health Dentistry, Shri. Yashwantrao Chavan Memorial Medical & Rural Development Foundation's Dental College & Hospital, Ahmednagar, Maharashtra, India.
    Introduction: Mishri is one of the form of smokeless tobacco, which is a roasted, powdered preparation made by baking tobacco on a hot metal plate until it is uniformly black, after which it is powdered. It is noted that mishri use is more commonly used by the women of low socioeconomic status, hence the need was felt to conduct this study among women mishri users of slums. Also, the consequences of mishri use are little known, hence an effort is made to find out its ill-effect on oral health. Read More

    Low-power laser irradiation inhibits arecoline-induced fibrosis: an in vitro study.
    Int J Oral Sci 2017 Mar 24;9(1):38-42. Epub 2017 Feb 24.
    School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Oral submucous fibrosis (OSF) is a potentially malignant disorder that is characterized by a progressive fibrosis in the oral submucosa. Arecoline, an alkaloid compound of the areca nut, is reported to be a major aetiological factor in the development of OSF. Low-power laser irradiation (LPLI) has been reported to be beneficial in fibrosis prevention in different damaged organs. Read More

    Betel nut chewing, oral premalignant lesions, and the oral microbiome.
    PLoS One 2017 22;12(2):e0172196. Epub 2017 Feb 22.
    University of Guam Cancer Research Center, Mangilao, Guam, United States of America.
    Oral cancers are attributed to a number of causal agents including tobacco, alcohol, human papillomavirus (HPV), and areca (betel) nut. Although betel nut chewing has been established as an independent cause of oral cancer, the mechanisms of carcinogenesis are poorly understood. An investigation was undertaken to evaluate the influence of betel nut chewing on the oral microbiome and oral premalignant lesions. Read More

    Serum Iron and Haemoglobin Estimation in Oral Submucous Fibrosis and Iron Deficiency Anaemia: A Diagnostic Approach.
    J Clin Diagn Res 2016 Dec 1;10(12):ZC54-ZC58. Epub 2016 Dec 1.
    Lecturer, Department of Oral Medicine and Radiology, Goa Dental College and Hospital , Bambolim, Goa, India .
    Introduction: Oral Submucous Fibrosis (OSMF) is a premalignant condition with potential malignant behaviour characterized by juxta-epithelial fibrosis of the oral cavity. In the process of collagen synthesis, iron gets utilized, by the hydroxylation of proline and lysine, leading to decreased serum iron levels. The trace element like iron is receiving much attention in the detection of oral cancer and precancerous condition like OSMF as it was found to be significantly altered in these conditions. Read More

    Recent updates on electronic cigarette aerosol and inhaled nicotine effects on periodontal and pulmonary tissues.
    Oral Dis 2017 Feb 6. Epub 2017 Feb 6.
    Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.
    E-cigarette-derived inhaled nicotine may contribute to the pathogenesis of periodontal and pulmonary diseases in particular via lung inflammation, injurious, and dysregulated repair responses. Nicotine is shown to have antiproliferative properties and affects fibroblasts in vitro, which may interfere in tissue myofibroblast differentiation in e-cig users. This will affect the ability to heal wounds by decreasing wound contraction. Read More

    Oral squamous cell carcinoma in the background of oral submucous fibrosis is a distinct clinicopathological entity with better prognosis.
    J Oral Pathol Med 2017 Jan 27. Epub 2017 Jan 27.
    Department of Oral and Maxillofacial Pathology & Microbiology, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.
    Background: The aim of this study was to compare the clinicopathological features of oral squamous cell carcinoma in the background of oral submucous fibrosis (OSCC-OSMF) and oral squamous cell carcinoma (OSCC).

    Methods: A total of 217 cases of OSCC were retrieved from achieves for the analysis. OSCC-OSMF cases were segregated on the basis of history and clinicopathological parameters. Read More

    [Clinical effectiveness of salvianolic acid B and triamcinolone acetonide in treatment of oral submucous fibrosis].
    Zhonghua Kou Qiang Yi Xue Za Zhi 2017 Jan;52(1):16-21
    Department of Oral Mucous Disease, Stomatology Center, Affiliate Haikou Hospital of Central South University Xiangya Medical School & Hainan Provincial Stomatology Center, Haikou 570208, China.
    Objective: To evaluate the clinical effectiveness of salvianolic acid B (SA-B) and triamcinolone acetonide (TA) by means of combined intralesional injection in the treatment of oral submucous fibrosis (OSF). Methods: According to clinical findings and symptoms, TA combined with SA-B were consecutively applied intralesionally 1 time weekly for 30 times. Mouth opening degree, color change of the buccal mucosae and numeral increase of the capillary vessels were determined by degree Ⅰ-Ⅳ visual analog scale were evaluated at 12, 24, and 36 months, respectively. Read More

    The Insight for Initiation and Maintenance of Areca nut chewing Habit and its Effects on Oral Health Status among School Age Population in Western Rajasthan, India.
    J Clin Diagn Res 2016 Nov 1;10(11):ZC15-ZC18. Epub 2016 Nov 1.
    Postgraduate Student, Department of Oral and Maxillofacial Pathology, Vyas Dental College and Hospital , Jodhpur, Rajasthan, India .
    Introduction: Areca nut is highly carcinogenic according to International Agency for Research on Cancer (IARC). Its usage is continuously increasing in children and adolescents in India.

    Aim: The aim of the study was to understand the reasons for the development of the areca nut chewing habit at early age. Read More

    Myofibroblasts could be recruited in a chemokine (C-C motif) ligand 2-dependent manner in pathogenesis of oral submucous fibrosis.
    J Oral Pathol Med 2016 Dec 28. Epub 2016 Dec 28.
    Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
    Background: Monocyte chemoattractant protein-1 (CCL2) is a major profibrotic mediator with a proven role in fibrosis of different organs of the body. Recently, increased fibrosis in oral submucous fibrosis (OSMF) is linked with betel quid-related chronic irritation and myofibroblast. Hence, this study is designed to investigate expression of CCL2 in OSMF and its correlation with myofibroblasts. Read More

    Omega 3: a novel treatment agent in oral submucous fibrosis: a pilot study.
    J Oral Pathol Med 2016 Dec 27. Epub 2016 Dec 27.
    Department of Public health dentistry, Dr. D.Y.Patil Dental College & Hospital, DPU, Pune, Maharashtra, India.
    Background: Oral submucous fibrosis (OSF) is a chronic debilitating disease and a premalignant condition of the oral cavity. It is well known for its impervious nature to medical therapy. Omega-3 polyunsaturated fatty acids have been reported to have anti-inflammatory properties. Read More

    Mandibular Canal Widening and Bell's Palsy: Sequelae of Perineural Invasion in Oral Cancer.
    Case Rep Dent 2016 29;2016:3010934. Epub 2016 Nov 29.
    Department of Oral and Maxillofacial Surgery, A.B. Shetty Memorial Institute of Dental Sciences, Mangalore, India.
    Perineural invasion is an underrecognized route of metastatic spread along the nerve bundles within the nerve sheath into the surrounding tissues. It hinders the ability to establish local control as tumour cells can traverse along nerve tracts well beyond the extent of any local invasion rendering them inoperable and unresectable. Perineural invasion is a marker of poor prognosis. Read More

    Breath Alkane as an index of severity for oral submucous fibrosis: A new perspective?
    Med Hypotheses 2017 Jan 16;98:18-20. Epub 2016 Nov 16.
    Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Cosham, Portsmouth PO6 3LY, United Kingdom.
    Oral submucous fibrosis (OSMF) is a devastating disease commonly seen in the Asian subcontinent that results in significant functional morbidity for patients and has a high potential for malignant transformation. Over the last three decades, different diagnostic methods have been described to quantify and grade OSMF severity. Some methods have been used with perceived favorable outcomes although recurrence and malignant transformation remains a problem in many cases, and OSMF presents a major therapeutic challenge. Read More

    Effect of curcumin on the expression of p53, transforming growth factor-β, and inducible nitric oxide synthase in oral submucous fibrosis: A pilot study.
    J Investig Clin Dent 2016 Dec 17. Epub 2016 Dec 17.
    Department of Pathology, Govind Ballabh Pant Hospital, New Delhi, India.
    Aim: The purpose of the present study was to find out the expression of p53, transforming growth factor-β TGF-β), and inducible nitric oxide synthase (iNOS) in oral submucous fibrosis (OSMF), proteins implicated in its pathophysiology, as well as malignant transformation. We also sought to determine the effect of curcumin on the expression of these markers through immunohistochemistry.

    Methods: The expression of p53, TGF-β, and iNOS was evaluated through immunohistochemistry in 28 patients with OSMF before and after treatment with curcumin. Read More

    Versatility of nasolabial flaps for the management of severe trismus in oral submucous fibrosis.
    Indian J Dent Res 2016 Sep-Oct;27(5):492-497
    Director and Consultant, Balaji Dental and Craniofacial Hospital, Chennai, Tamil Nadu, India.
    Background: Oral submucous fibrosis (OSMF) is a chronic insidious disease affecting any part of the oral cavity and sometimes the pharynx. It is a collagen-related disorder predominantly associated with tobacco/areca nut chewing habit and characterized by progressive hyalinization of the submucosa. Prevalence of OSMF is 2. Read More

    Rebamipide to Manage Stomatopyrosis in Oral Submucous Fibrosis.
    J Contemp Dent Pract 2016 Dec 1;17(12):1009-1012. Epub 2016 Dec 1.
    Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal University, Mangaluru, Karnataka India.
    Introduction: Oral submucous fibrosis (OSF) causes progressive debilitating symptoms, such as oral burning sensation (stomatopyrosis) and limited mouth opening. The standard of care (SOC) protocol includes habit cessation, intralesional steroid and hyaluronidase injections, and mouth opening exercises. The objective of the study was to evaluate efficacy of rebamipide in alleviating burning sensation of the oral mucosa in OSF in comparison with SOC intralesional steroid injections. Read More

    Expression pattern of DKK3, dickkopf WNT signaling pathway inhibitor 3, in the malignant progression of oral submucous fibrosis.
    Oncol Rep 2017 Feb 8;37(2):979-985. Epub 2016 Dec 8.
    Department of Oral and Maxillofacial - Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China.
    Oral squamous cell carcinoma (OSCC) is a common malignant neoplasm of the head and neck. Oral submucous fibrosis (OSF) is one of its pre-cancerous lesions; however, the key molecular events in the tumorigenesis of OSF remain elusive. Dickkopf WNT signaling pathway inhibitor 3 (DKK3) is one of the Wnt antagonists, and its downregulation and methylation have been reported in multiple malignancies, while no report of its expression in the carcinogenesis of OSF exists. Read More

    Evaluation of Internal Echogenic Pattern of Masseter in Subjects with Myofascial Pain/ Myositis, Oral Submucous Fibrosis, Chewers, Bruxers and Healthy Individuals- A Preliminary Ultrasonographic Study.
    J Dent (Shiraz) 2016 Dec;17(4):361-366
    Dept. of Oral Medicine and Radiology, D.A. Pandu Memorial R. V. Dental College, Bengaluru, Ragiv Gandhi University of Health Sciences, India.
    Statement Of The Problem: The masseter is generally involved in myofascial pain, myositis, oral submucous fibrosis (OSMF), bruxism, and in subjects with habitual tobacco/arecanut chewing. In all the above conditions, changes in the internal echogenic pattern on ultrasonography of the muscle may be observed.

    Purpose: The present study aimed at evaluating the internal echogenic pattern of masseter by ultrasonography in subjects with various conditions affecting masster muscle. Read More

    Molecular Pathology of Malignant Transformation of Oral Submucous Fibrosis.
    J Environ Pathol Toxicol Oncol 2016 ;35(3):193-205
    Department of Oral Pathology, Dr. R. Ahmed Dental College and Hospital, Karnataka, India.
    Oral submucous fibrosis (OSF) is prevalent mostly in Southeast Asia, particularly in the Indian subcontinent. Chewing betel nuts and betel leaves, with or without tobacco, has been associated with OSF. Betel quid contents including guvacine, arecoline, guvacoline, arecaidine, and chavibetol are considered to play an important part in the occurrence of OSF. Read More

    Comparison of Therapeutic Efficacy of Placental Extract with Dexamethasone and Hyaluronic Acid with Dexamethasone for Oral Submucous Fibrosis - A Retrospective Analysis.
    J Clin Diagn Res 2016 Oct 1;10(10):ZC63-ZC66. Epub 2016 Oct 1.
    Reader, Department of Oral Medicine and Radiology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth , Vadodara, Gujarat, India .
    Introduction: Oral Submucous Fibrosis (OSMF) is a potentially malignant disease of the oral cavity associated with betel nut chewing. The management of OSMF has been a subject of controversy and no definitive and widely accepted treatment is currently available for this condition.

    Aim: To retrospectively evaluate the therapeutic efficacy of two treatment regimens (placental extract with dexamethasone and hyaluronic acid with dexamethasone) for the treatment of OSMF. Read More

    Efficacy and Safety of Intralesional Xantinol Nicotinate in the Treatment of Various Stages of Oral Submucous Fibrosis.
    J Clin Diagn Res 2016 Oct 1;10(10):ZC34-ZC37. Epub 2016 Oct 1.
    Senior Lecturer, Department of Oral Medicine and Radiology, Kothiwal Dental College and Research Centre , Moradabad, Uttar Pradesh, India .
    Introduction: Oral Submucous Fibrosis (OSMF) is one of the most prevalent potentially malignant disorders seen in South east population since ages. Despite the extensive amount of research held in this field, its treatment still remains a challenge. In this study, we present our experience in successfully managing OSMF with intralesional injections of a peripheral vasodilator namely xantinol nicotinate. Read More

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