1,699 results match your criteria Oral Submucous Fibrosis


Oral Fibrosis and Oral Cancer: From Molecular Targets to Therapeutics.

Int J Mol Sci 2022 May 30;23(11). Epub 2022 May 30.

School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan.

Oral submucous fibrosis (OSF) belongs to a group of potentially malignant disorders that are characterized by the progressive fibrosis of the lining mucosa as well as an increasing loss of tissue mobility [... Read More

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Clinicopathological factors associated with progression of oral submucous fibrosis: A population-based retrospective study.

Oral Oncol 2022 Jul 2;130:105949. Epub 2022 Jun 2.

Hunan Key Laboratory of Oral Health Research & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, No. 72, Xiangya Street, Kaifu District, Changsha, Hunan 410008, PR China. Electronic address:

Oral submucosal fibrosis was one of the oral potentially malignant disorders, which has become a global epidemic disease. This study aimed to investigate the clinicopathological features associated with the disease progression of oral submucosal fibrosis. We recruited 700 cases of oral submucosal fibrosis in the Department of oral pathology, Xiangya Stomatological Hospital, Central South University from July 1996 to July 2019, and analyzed the association among staging of oral submucosal fibrosis and age, sex, sites, duration of areca nut chewing. Read More

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Are There Betel Quid Mixtures Less Harmful than Others? A Scoping Review of the Association between Different Betel Quid Ingredients and the Risk of Oral Submucous Fibrosis.

Biomolecules 2022 May 2;12(5). Epub 2022 May 2.

Centre for Immunology and Regenerative Medicine, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK.

Oral submucous fibrosis (OSF) is a potentially malignant condition of the oral cavity characterized by progressive fibrosis of the submucosal tissues. OSF is typically associated with the use of betel quid (BQ), a chewing package made of natural products (e.g. Read More

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A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis.

Antioxidants (Basel) 2022 Apr 28;11(5). Epub 2022 Apr 28.

Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, Melbourne, VIC 3053, Australia.

Oral submucous fibrosis (OSMF) is a chronic oral potentially malignant disorder (OPMD). It is described as a scarring disease of the oral mucosa associated with excess oxidants and insufficient antioxidants. While it is becoming increasingly accepted that oxidative stress results in excessive accumulation of collagen and progressive fibrosis of the submucosal tissues, there is limited data regarding the moderation of oxidative stress to initiate or prevent OSMF. Read More

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The Antifibrotic and the Anticarcinogenic Activity of Capsaicin in Hot Chili Pepper in Relation to Oral Submucous Fibrosis.

Front Pharmacol 2022 4;13:888280. Epub 2022 May 4.

Department of Oral Pathology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, India.

A burning sensation on eating spicy foods purportedly supports the role of capsaicin, an active component of chili peppers, in the etiology of oral submucous fibrosis (OSF). Although the mast cell mediators and activated P2X receptors induce a constant burning sensation through an ATP-dependent mechanism, it is the activation of the transient receptor potential vanilloid 1 (TRPV-1) receptor by capsaicin that aggravates it. The molecular basis for the burning pain in OSF is thus attributable to the activation of TRPV1. Read More

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Oral submucous fibrosis induced by graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.

Oral Oncol 2022 Jul 17;130:105919. Epub 2022 May 17.

Department of Periodontics and Oral Medicine, Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University & Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxillofacial and Regenerative Medicine, Changsha 410008, China. Electronic address:

Graft-versus-host disease (GVHD) is one of the most common and serious complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). About 45%∼83% of patients develop GVHD in the oral cavity. There has no medical records of oral submucous fibrosis (OSF) induced by GVHD after allo-HSCT, which should be brought to the attention of dentists. Read More

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Analytical Study Of Salivary Mmp-12 Expression In Oral Submucous Fibrosis.

J Ayub Med Coll Abbottabad 2022 Apr-Jun;34(2):247-250

Department of Oral and Maxillofacial Surgery, Dow university of Health Sciences, Karachi.

Background: Oral submucous fibrosis (OSF) is majorly a pathology pertaining to Asian population, reported most in Pakistan, India, Nepal, Bangladesh, and Taiwan. Equilibrium existing between Matrix metalloproteinases (MMP) & tissue inhibitors of matrix metalloproteinases is imperative for the normal integrity of connective tissues. However, this mechanism is disturbed in the presence of OSF, resulting in an increase in the extracellular matrix. Read More

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The diverse role of oral fibroblasts in normal and disease.

J Oral Maxillofac Pathol 2022 Jan-Mar;26(1):6-13. Epub 2022 Mar 31.

Department of Oral Pathology and Microbiology, Priyadharshini Dental College and Hospital, Tiruvallur, Tamil Nadu, India.

Fibroblasts are the major cellular component of the connective tissue. They differ both structurally and functionally based on their location. The oral fibroblasts vary from the dermal fibroblasts in their origin, properties and also functions. Read More

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Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer.

Front Pharmacol 2022 20;13:825266. Epub 2022 Apr 20.

Computational Biology and Bioinformatics Lab, Institute of Life Sciences, Bhubaneswar, India.

Among oral diseases, oral cancer is a critical health issue due to its life-threatening potential. Globocan, in its 2020 report, estimated ∼0.37 million new cases of oral cancer, with the majority of them coming from the Asian continent. Read More

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Prevalence of oral submucous fibrosis among areca nut chewers: A systematic review and meta-analysis.

Oral Dis 2022 May 3. Epub 2022 May 3.

Oral Oncology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

Background: Worldwide millions peoples consume AN who are at risk of OSMF. Prevalence of OSMF is reported between 0.03% and 30% irrespective of AN habit. Read More

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Depleting levels of endogenous anti-oxidant superoxide dismutase in oral sub-mucous fibrosis: A systematic review and meta-analysis.

J Oral Biol Craniofac Res 2022 May-Jun;12(3):343-351. Epub 2022 Apr 14.

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry Jazan University, Jazan, Saudi Arabia.

Objective: The systematic review is aimed to assess the antioxidant status by superoxide dismutase level in oral sub-mucous fibrosis using available literature.

Materials And Methods: A literature search was accomplished electronically in Pubmed (MeSH), Science Direct, Scopus, Web of Science core collection, Cochrane, and Cross-reference, using the keywords such as 'oral submucous fibrosis,' 'antioxidant status' and 'superoxide dismutase.'

Results: Of the 352 articles identified, only 16 satisfied the selection criteria and were included in the systematic review. Read More

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Clinical Assessment of Efficacy of Omega 3 in Oral Submucous Fibrosis Patients - A Randomized Controlled Trial.

Asian Pac J Cancer Prev 2022 Apr 1;23(4):1185-1192. Epub 2022 Apr 1.

DPU, Dr. D.Y. Patil Dental College & Hospital, Mahesh Nagar, Pimpri, Pune, Maharashtra, India.

Background: Oral submucous fibrosis (OSMF) is a chronic, potentially malignant condition affecting the oral cavity. Omega 3 has shown innumerable health benefits in yesteryears. So, the aim of the study was to evaluate the efficacy of Omega 3 in the medical management of this disease. Read More

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Analysis Of Serum Iron And Heamoglobin Level In Patients With Oral Submucous Fibrosis.

J Ayub Med Coll Abbottabad 2022 Jan-Mar;34(1):173-177

Dow University of Health Sciences Karachi, Pakistan.

Background: OSMF is chronic underlying disease. The disease is well recognized and had an importance due to high malignant transformation rate. Multiple etiological factors are found responsible in the pathogenesis of the disease course. Read More

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Comprehensive analysis of microRNAs and their target genes in oral submucous fibrosis.

Oral Dis 2022 Apr 25. Epub 2022 Apr 25.

Department of Oral Pathology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, India.

The objective of the study is to understand the role of experimentally validated microRNAs (miRNAs) contributing to the acquisition of oncogenic phenotype in oral submucous fibrosis (OSF) by computational analysis. A comprehensive review was carried out to corroborate and summarize altered miRNA expression in OSF by retrieving relevant publications querying MEDLINE, Web of Science, Embase, and Scopus. The association between the miRNA-mRNA was performed using miRTarBase 8. Read More

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Areca Nut and Oral Cancer: Evidence from Studies Conducted in Humans.

J Dent Res 2022 Apr 22:220345221092751. Epub 2022 Apr 22.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei.

Areca nut chewing is one of the major risk factors for oral cancer, with large-magnitude risks reported in studies comparing betel quid chewers and never users, and it has been evaluated as a group 1 carcinogen by the International Agency for Research on Cancer. Data from a high-quality meta-analysis examining risk estimates are presented in summary form with additional information from more recent studies (pooled adjusted relative risk, 7.9; 95% CI, 7. Read More

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Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis.

J Clin Med 2022 Mar 24;11(7). Epub 2022 Mar 24.

Department of Oral Medicine, Guy's & St Thomas' NHS Foundation Trust, London SE1 9RT, UK.

Oral submucous fibrosis (OSF) is a chronic progressive condition affecting the oral cavity, oropharynx and upper third of the oesophagus. It is a potentially malignant disorder. The authors collated and analysed the existing literature to establish the overall malignant transformation rate (MTR). Read More

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Quality of Life in Oral Submucous Fibrosis: A Systematic Review.

J Maxillofac Oral Surg 2022 Mar 7;21(1):14-24. Epub 2021 Feb 7.

Pulmonary Medicine, AIIMS Jodhpur, Jodhpur, India.

Backgrounds: Oral submucous fibrosis (OSMF) is a chronic, insidious disease and is said to have a multifactorial origin with varied clinical manifestation of repeated oral ulcers, intolerance to spicy food, mucosal blanching resulting in stiffness of the oral mucosa and formation of taut bands leading to reduced mouth opening. We designed this study to systematically review the literature on QOL in OSMF and hope to make recommendations for future course of QOL assessment in OSMF.

Methods: An electronic bibliographic search of studies was done from year 1900-2019 using specified keywords. Read More

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Evaluation of Digital Palmar Dermatoglyphics in Oral Submucous Fibrosis and Leukoplakia: A Prospective Comparative Clinical Study.

J Maxillofac Oral Surg 2022 Mar 1;21(1):219-226. Epub 2020 Jul 1.

Department of Conservative and Endodontics, Awadh Dental College and Hospital, Jamshedpur, India.

Aim: To analyze and compare digital dermatoglyphic patterns in patients with oral leukoplakia and oral submucous fibrosis and their role as noninvasive diagnostic tool.

Materials And Methods: Two hundred patients were segregated into four groups of 50 patients each with oral leukoplakia, oral submucous fibrosis, and patients with habits but no lesions were included. They were compared with 50 subjects without habits and without lesions. Read More

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Molecular profiling of oral squamous cell carcinoma associated with oral submucous fibrosis.

J Cancer Res Ther 2022 Jan-Mar;18(1):55-65

Department of Oral and Maxillofacial Pathology and Microbiology, YMT Dental College and Hospital, Navi Mumbai, Maharashtra, India.

Context: Areca nut, a causative factor for oral submucous fibrosis (OSMF), is identified as a Group 1 human carcinogen. Oral squamous cell carcinoma (OSCC) associated with OSMF is now one of the most common malignancies in South and Southeast Asian countries.

Aim: The present study was aimed to have clarity whether OSCC associated with OSMF is a pathologically different disease having different prognosis. Read More

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Significance of HIF-1α and CD105 in establishing oral squamous cell carcinoma associated with oral submucous fibrosis a distinct clinicopathological entity.

J Cancer Res Ther 2022 Jan-Mar;18(1):33-41

Department of Oral Pathology and Microbiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India.

Context: Oral squamous cell carcinoma associated with oral submucous fibrosis (OSCC with OSMF) is clinicopathologically a distinct entity. However, scientific proof in view of assessment of biomarkers of hypoxia and neoangiogenesis to differentiate them are lacking. The expression of hypoxia-inducible factor 1-α (HIF-1α) and CD105 in OSCC with and without OSMF possibly will be explicated along these lines. Read More

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N6-methyladenosine modification contributes to arecoline-mediated oral submucosal fibrosis.

J Oral Pathol Med 2022 May 4;51(5):474-482. Epub 2022 Apr 4.

Department of Oral Medicine, Foshan Stomatological Hospital, Medical College of Foshan University, Foshan, Guangdong, China.

Background: Oral submucosal fibrosis (OSF) is a precancerous condition that closely related to the habit of chewing betel nut. The OSF patients of 3%-19% may develop cancer, and this probability is increasing year by year. Epigenetics modifications have been reported as part of the pathogenesis of OSF. Read More

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CC group of chemokines and associated gene expression of transcription factors: Deciphering immuno-pathogenetic aspect of oral submucous fibrosis.

Dis Mon 2022 Mar 24:101351. Epub 2022 Mar 24.

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Kingdom of Saudi Arabia. Electronic address:

Background: Oral submucous fibrosis (OSMF) is a chronic disease with significantly increasing malignant transformation rate. To date the pathogenesis of OSMF has been considered to be associated with areca nut constituents and their action on fibroblasts. However, fibrosis is also associated with immunological factors such as chemokines. Read More

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Evaluation of Copper Levels in Dental Calculus of OSF Patients with Chewing Dried Areca-Nut Quids in Hunan Province of Mainland China.

Biol Trace Elem Res 2022 Mar 24. Epub 2022 Mar 24.

Department of Oral and Maxillofacial Surgery, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, People's Republic of China.

Dental calculus is a potential material that can be used for assessing chronic exposure to trace heavy metals in oral cavity as it is a long-term reservoir. The aim of this study was to investigate the correlation between dental calculus copper levels and risk of oral submucous fibrosis (OSF) due to chewing dried areca-nut quids in Mainland China. This study included 34 OSF (grade 1) sufferers with dried areca-nut quids chewing as the patient group and 23 healthy individuals without areca-nut chewing as the control group. Read More

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Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Tumours of the Oral Cavity and Mobile Tongue.

Head Neck Pathol 2022 Mar 21;16(1):54-62. Epub 2022 Mar 21.

Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka.

The fifth chapter of the upcoming fifth edition of the 2022 World Health Organization Classification of Tumours of the Head and Neck titled Tumours of the oral cavity and mobile tongue, has had some modifications from the 2017 fourth edition. A new section "Non-neoplastic Lesions", introduces two new entries: necrotizing sialometaplasia and melanoacanthoma. The combined Oral potentially malignant disorders and Oral epithelial dysplasia section in the 2015 WHO has now been separated and submucous fibrosis and HPV-associated dysplasia are also discussed in separate sections. Read More

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Potential role of fibroblast senescence in malignant transformation of oral submucous fibrosis.

Oral Oncol 2022 04 15;127:105810. Epub 2022 Mar 15.

Department of Oral Medicine and Radiology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science, Chennai, India.

Oral Submucous Fibrosis (OSMF) is a disorder that occurs primarily due to the usage of betel nut and paan masala. The rate of malignant transformation from OSMF is 26 %. There are several markers to predict this malignant transformation such as inflammatory mediators, hypoxia, Cell cycle alteration, alteration in oncosuppressor genes, angiogenesis-related molecules, genetic susceptibility, and senescence. Read More

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Pulmonary function test: A critical domain in oral submucous fibrosis patients.

J Educ Health Promot 2022 31;11:26. Epub 2022 Jan 31.

Department of Oral Medicine and Radiology, Rama Dental College, Kanpur, Uttar Pradesh, India.

Introduction: The study aims to measure and compare pulmonary function tests (PFTs) in oral submucous fibrosis (OSMF) patients (smokers/nonsmokers) and normal individuals.

Materials And Methods: The study population included 150 participants that comprised 50 nonsmoker OSMF patients, 50 OSMF patients who smoke as well, and 50 patients with no deleterious habits. Spirometer was used to assess PFT. Read More

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January 2022

Role of programmed cell death 4 in myofibroblast differentiation in oral submucous fibrosis.

J Oral Maxillofac Pathol 2021 Sep-Dec;25(3):430-436. Epub 2022 Jan 11.

Department of Oral Biology and Biomedical Engineering, School of Dental Medicine, Engineering and Applied Sciences, University at Buffalo, Buffalo, NY, USA.

Background: Fibrosis is an uncontrolled healing process, led by persistent differentiation of fibroblast to alpha-smooth muscle actin (αSMA) positive activated fibroblast or myofibroblast. Oral submucous fibrosis (OSMF) is one such condition that is associated with areca nut use. Recently, Programmed Cell Death 4 (PDCD4), a pro-apoptotic marker, has been shown to modulate fibroblast differentiation in various organ fibrosis. Read More

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January 2022

A study on oral mucosal changes among tobacco users.

J Oral Maxillofac Pathol 2021 Sep-Dec;25(3):470-477. Epub 2022 Jan 11.

Gnanam and Rajamurugan Dental Clinic, Venkatapuram, Ambattur, Chennai, Tamil Nadu, India.

Introduction: Oral malignancies account for about 4% in males and 2% in females among all malignant tumors. Tobacco use in the oral cavity can cause potentially malignant disorders such as oral submucous fibrosis (OSMF), leukoplakia and oral squamous cell carcinoma (OSCC). Factors such as lifestyle changes, habits and limited access to health care increase cancer development and morbidity. Read More

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January 2022

Effect of trans retinoic acid on patients with oral submucous fibrosis-randomized single-blind monocentric study.

J Oral Maxillofac Pathol 2021 Sep-Dec;25(3):411-416. Epub 2022 Jan 11.

Department of Prosthodontics, ITS-Cente for Dental Studies and Research, Greater Noida, Uttar Pradesh, India.

Various treatment modalities have been practiced for the suppression of premalignant conditions such as oral submucous fibrosis (OSMF) to prevent their differentiation into malignant lesions. Conventional treatment includes steroids, enzymes like hyaluronidase, trypsin, chymotrypsin and placental extracts which are advocated intralesionally and oral drugs like carotenoids, alpha lipoic acid, lycopene, vitamins, microelements and tea pigments have also been advocated.In this study, a total number of 30 patients with OSMF were taken and randomly divided into two groups with 15 patients each according to Khanna and Andrade group of classification 1995. Read More

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January 2022

Is micronucleus assay in oral exfoliated cells a suitable biomarker for predicting cancer risk in individuals with oral potentially malignant disorders? A systematic review with meta-analysis.

Pathol Res Pract 2022 Apr 25;232:153828. Epub 2022 Feb 25.

Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil. Electronic address:

This systematic review (SR) with meta-analysis aimed to evaluate the scientific data related to cytogenetic damage in oral exfoliated cells of patients diagnosed with oral potentially malignant disorders (OPMDs). The SR was conducted according to the PRISMA-P guidelines. The PICOS (Participants, Intervention, Comparison, Outcome, and Study Design) strategy was used to answer the question: "Is micronucleus assay in oral exfoliated cells a suitable biomarker for predicting cancer risk in individuals with OPMDs?" The search strategy was performed in the following electronic databases: PubMed, Medline, Scopus and Web of Science. Read More

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