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    Comment on "TFM classification and staging of oral submucous fibrosis: A new proposal".
    J Oral Pathol Med 2018 Apr 23. Epub 2018 Apr 23.
    Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
    We read with great interest an article titled 'TFM classification and staging of oral submucous fibrosis: a new proposal' published by Arakeri et al. One could sense the virtuous intention for finding much needed comprehensive grading system for one of the most dreadful pathologies in Asian countries, oral submuous fibrosis (OSF). Trismus, fibrosis and malignant transformation are the three most aptly chosen parameters, as they not only reflect patient's disease severity but also are predictors of malignant potential. Read More

    Clinical features and presentation of oral potentially malignant disorders.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Apr 4. Epub 2018 Apr 4.
    Emeritus Professor, King's College London, UK; WHO Collaborating Centre for Oral Cancer, London, UK. Electronic address:
    Oral potentially malignant disorders (OPMDs) are conditions that precede the onset of invasive cancers of the oral cavity. The term embraces precancerous lesions and conditions referred to in earlier World Health Organization (WHO) definitions. Leukoplakia is the most common OPMD; erythroplakia, although rare, is more serious. Read More

    Butylidenephthalide abrogates the myofibroblasts activation and mesenchymal transdifferentiation in oral submucous fibrosis.
    Environ Toxicol 2018 Apr 17. Epub 2018 Apr 17.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
    Oral submucous fibrosis (OSF) is a premalignant disorder in the oral cavity, and areca nut chewing habit has been implicated in the persistent activation of myofibroblasts and the subsequent fibrosis. Therefore, it is critical to ameliorate the excessive activities of myofibroblasts prior to the malignant transformation of OSF. In the current study, we evaluated the cytotoxicity of butylidenephthalide (BP), a major phthalide ingredient of Angelica sinensis, in fibrotic buccal mucosal fibroblasts (fBMFs) as well as various myofibroblast hallmarks, including the phenotypical characteristics and fibrosis-related markers. Read More

    Management update of potentially premalignant oral epithelial lesions.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Mar 23. Epub 2018 Mar 23.
    Department of Oral and Maxillofacial Surgery, North Memorial Medical Center, Minneapolis, MN, USA. Electronic address:
    The term oral potentially malignant disorders, proposed at the World Health Organization workshop in 2005, has now been renamed potentially premalignant oral epithelial lesions (PPOELs). It is important to differentiate among PPOELs, which is a broad term to define a wide variety of clinical lesions, and oral epithelial dysplasia, which should be reserved specifically for lesions with biopsy-proven foci of dysplasia. PPOELs encompass lesions that include leukoplakia, erythroplakia, erythroleukoplakia, lichen planus, and oral submucous fibrosis. Read More

    Is matrix stiffness a cause for malignant transformation of OSF?
    J Oral Pathol Med 2018 Apr 14. Epub 2018 Apr 14.
    Department of Oral Pathology & Microbiology, Yerala Dental College and Hospital, Kharghar, Mumbai, 410210.
    Fibrosis is a pathological process characterized by mesenchymal cell infiltration and proliferation in the interstitial space, which occurs in order to repair epithelial injuries leading to the formation of granulation tissue. [1] The relationship between fibrosis and the development of carcinoma was described for the first time by Friedrich in 1939. [2] Since then, multiple studies have been attempted to determine the relationship between fibrosis and development of malignancy. Read More

    Immunohistochemical expression of polo-like kinase 1 in oral squamous cell carcinoma and oral submucous fibrosis.
    Indian J Dent Res 2018 Mar-Apr;29(2):171-175
    Department of Pathology, Tagore Medical College and Hospital, Chennai, Tamil Nadu, India.
    Context: Polo-like kinase 1 (PLK1) is a critical molecule in the proliferation of several human cancers. Overexpression of PLK1 has been correlated with cancer cell proliferation and lower overall survival rates. Although PLK1 has been studied in various tumors, information regarding its expression in oral cancer and precancer is limited. Read More

    "Introducing Modified Dakkak and Bennett Grading System for Indian Food in Oral Submucous Fibrosis": A Dharwad Study.
    J Diet Suppl 2018 Apr 6:1-8. Epub 2018 Apr 6.
    a Department of Oral Medicine & Radiology , Century International Institute of Dental Science & Research Centre , Poinachi, Kasargod , Kerala , India.
    Oral submucous fibrosis (OSMF) is one of the "diseases of civilization" because of the large differences in prevalence among races, geographic areas, and individuals at different socioeconomic levels. It is a premalignant condition strongly associated with the habit of chewing areca nuts. This study is to compare the scoring system in relation to the burning sensation of mouth and dysphagia using the visual analog scale (VAS) and Dakkak and Bennett grading system for Indian food, respectively, in OSMF patients. Read More

    Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Mar 1. Epub 2018 Mar 1.
    Emory University School of Medicine, Atlanta Oral Pathology, Decatur, GA, USA. Electronic address:
    The term oral potentially malignant disorders (OPMDs) describes a recognizable group of mucosal diseases that have a risk of progressing to squamous cell carcinoma. Oral leukoplakia, the most common OPMD, has a 1% prevalence and reported malignant transformation rates of 2% to 5%. Other OPMDs include erythroplakia, erythroleukoplakia, submucous fibrosis, lesions of reverse smokers, and inherited genetic disorders, such as Fanconi anemia. Read More

    Quality of Life-related "Patient-reported Outcome Measures" in Oral Submucous Fibrosis Patients.
    J Contemp Dent Pract 2018 Mar 1;19(3):331-338. Epub 2018 Mar 1.
    Division of Oral Pathology, Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University Jazan, Kingdom of Saudi Arabia.
    Aim: The aim of this study was to explore the patients' perspectives about the impact of oral submucous fibrosis (OSF) on life quality.

    Materials And Methods: Thirty clinically diagnosed OSF patients with a wide degree of disease severity and diverse range of sociodemographic profile were included in this study. Fourteen participants were interviewed and four focus group discussions were conducted in nonclinical settings. Read More

    Development & validation of oral health related quality of life measure in oral submucous fibrosis.
    Oral Dis 2018 Mar 23. Epub 2018 Mar 23.
    Department of Oral Pathology & Microbiology, Dr. D.Y. Patil Dental College & Hospital, Dr. D.Y. PatilVidyapeeth, Pune, Maharashtra State, India.
    Objective: The aim of this study was to develop and assess the validity and reliability of disease-specific oral health related quality of life (OHRQoL) instrument for oral submucous fibrosis (OSF).

    Materials And Methods: Items for the OHRQoL-OSF were generated from personal interviews and focus group discussions, the existing questionnaires, reviews of literature and inputs from expert's panel. Item reduction was performed by clinical impact method followed by pretesting of the developed questionnaire. Read More

    Retrograde intubation through nasal route in patients with limited mouth opening undergoing oral and maxillofacial surgery.
    J Oral Biol Craniofac Res 2018 Jan-Apr;8(1):30-34. Epub 2017 Aug 25.
    Department of anesthesia, Sri Sai College of Dental Surgery, Vikarabad, Telangana, India.
    Background: Patients with limited mouth opening (LMO) often associated with difficult intubation. Retrograde intubation is an alternative technique of establishing definitive airway in these patients when blind nasal intubation fails and fiberoptic bronchoscope is not available. We tested the retrograde intubation through nasal route in patients with LMO less than 2 cm. Read More

    Differential expression of organic cation transporter 3 in oral submucous fibrosis-associated buccal squamous cell carcinoma.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Mar 6. Epub 2018 Mar 6.
    Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:
    Objective: The aim of this study was to examine the expression of organic cation transporter 3 (OCT3) in patients with oral submucous fibrosis (OSF)-associated buccal squamous cell carcinoma (BSCC) and to explore its clinical significance.

    Study Design: A total of 56 tissue specimens were collected from patients, among which there were 13 specimens with normal buccal mucosa (NBM), 13 with oral submucous fibrosis (OSF), 10 with OSF-associated BSCC (BSCC-OSF), 10 with well-differentiated BSCC (BSCC-I), and 10 with poorly to moderately differentiated BSCC (BSCC-II+III), based on pathologic examination. The expression of OCT3 was detected by using immunohistochemistry and real-time quantitative reverse transcription polymerase chain reaction. Read More

    Sonographic imaging of fibrosis of oral mucosa and its correlation with clinical staging in oral submucous fibrosis.
    J Cancer Res Ther 2018 Jan-Mar;14(2):394-397
    Department of Oral Medicine and Radiology, Kamineni Institute of Dental Sciences, Nalgonda, Telangana, India.
    Background And Objectives: To evaluate the efficacy of ultrasonography (USG) as a noninvasive tool in assessing the severity of oral submucous fibrosis (OSMF) by measuring the submucosal thickness and also to correlate the sonographic changes with clinical staging.

    Materials And Methods: The submucosal thickness of the upper and lower labial mucosa, anterior and posterior portions of the right and left buccal mucosa were measured using ultrasound in 64 patients comprising of 32 OSMF patients and 32 controls. Among the controls, 16 were with a habit of chewing gutkha and 16 were without any habit history. Read More

    Analysis of images for detection of oral epithelial dysplasia: A review.
    Oral Oncol 2018 Mar 10;78:8-15. Epub 2018 Jan 10.
    Centre for Biomaterials, Cellular, and Molecular Theranostics, VIT University, Vellore 632014, India; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.
    This paper provides a review of various image analysis approaches that have been previously used for recognition of dysplasia in images of the epithelium of the oral cavity. This domain has become especially admissible with the uncovering of the importance of image analysis which can probably be an aid to subjective diagnosis by histopathologists. Oral malignancy is a rampant form of cancer found among people of the Indian subcontinent due to various deleterious habits like consumption of tobacco, areca nut, betel leaf etc. Read More

    Oral Submucous Fibrosis as an Overhealing Wound: Implications in Malignant Transformation.
    Recent Pat Anticancer Drug Discov 2018 Feb 26. Epub 2018 Feb 26.
    Department of Oral Pathology, Manipal College of Dental Sciences, Manipal University, Manipal - 576104. India.
    Background: Oral submucous fibrosis is an oral potentially malignant disorder with high incidence of malignant transformation and rising global prevalence. However, the genesis of oral submucous fibrosis is still unclear despite superfluity of literature. In the background of ineffective treatment, it is necessary to decode its onset and progression before designing customized treatment regimens. Read More

    Myofibroblasts in oral potentially malignant disorders: Is it related to malignant transformation?
    Oral Dis 2018 Mar;24(1-2):84-88
    Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
    In oral cancer, acquisition of α-smooth muscle actin (α-SMA)-positive fibroblasts, known as myofibroblasts or carcinoma-associated fibroblasts (CAF), is an important event for progression and metastasis. However, the contribution of myofibroblasts in oral potentially malignant disorders (OPMD) remains controversial. This systematic review provides evidence that immunodetection of myofibroblasts may identify oral submucous fibrosis (OSMF) with high risk of malignant transformation, but does not represent an auxiliary tool to predict the malignant potential of leukoplakia and erythroplakia, the most common OPMD. Read More

    Dysplastic features relevant to malignant transformation in atrophic epithelium of oral submucous fibrosis: A preliminary study.
    J Oral Pathol Med 2018 Apr 12;47(4):410-416. Epub 2018 Mar 12.
    Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, India.
    Background: The grading of oral epithelial dysplasia (OED) is not applicable to oral submucous fibrosis (OSMF) cases due to the presence of atrophic epithelium. The mucosal margins associated with resected OSCC specimens are often closely related to transformed cells. In this study, we compared the histomorphological alterations (dysplastic features) in the atrophic epithelium of OSMF patients with the mucosal margins of OSCC associated with OSMF (OSCC-OSMF). Read More

    Experimental study on TGF-β1-mediated CD147 expression in oral submucous fibrosis.
    Oral Dis 2018 Feb 19. Epub 2018 Feb 19.
    Centre of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
    Objective: Although previous evidence indicates that CD147 is closely involved in the progression of organ fibrosis and various signaling pathways have been proven to regulate its expression, the role of CD147 in oral submucous fibrosis (OSF) remain largely unknown.

    Methods: In the present study, we investigated the expression of CD147 and transforming growth factor β1 (TGF-β1) in human samples of an OSF tissue array by immunohistopathology. Pearson's correlation analysis was conducted to explore the correlation between CD147 and TGF-β1. Read More

    Malignant transformation of Taiwanese patients with oral leukoplakia: A nationwide population-based retrospective cohort study.
    J Formos Med Assoc 2018 May 7;117(5):374-380. Epub 2018 Feb 7.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address:
    Background/purpose: Oral leukoplakia (OL) is one of the clinically diagnosed oral potentially malignant disorders (OPMDs) with an increased risk of oral cancer development. In this study, we investigated the malignant transformation of OL in Taiwanese population.

    Methods: A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. Read More

    Angiogenesis and Fibrogenesis in Oral Submucous Fibrosis: A Viewpoint.
    J Contemp Dent Pract 2018 Feb 1;19(2):242-245. Epub 2018 Feb 1.
    Division of Oral Pathology, Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University Jazan, Kingdom of Saudi Arabia.
    Oral submucous fibrosis (OSF) is characterized by excessive fibrosis of submucosa. The degree of vascularity in OSF has always been a matter of debate. Angiogenesis is the key mechanism involved in regeneration and repair. Read More

    Podoplanin expression in oral potentially malignant disorders and oral squamous cell carcinoma.
    J Clin Exp Dent 2017 Dec 1;9(12):e1418-e1424. Epub 2017 Dec 1.
    Associate Professor, Department of Oral and Maxillofacial Pathology PMS College of Dental Science and Research, Thiruvananthapuram, Kerala, India.
    Background: Podoplanin is a type I transmembrane sialomucin-like glycoprotein that is specifically expressed in lymphatic endothelial cells. Studies have shown that assessment of podoplanin expression in the epithelial cells can be used to predict the malignant transformation of potentially malignant disorders and the metastatic tendency of primary head and neck squamous cell carcinoma. The aim of our study was to compare the expression of podoplanin in oral leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma with that in normal buccal mucosa by immunohistochemical methods. Read More

    TFM classification and staging of oral submucous fibrosis: A new proposal.
    J Oral Pathol Med 2018 Apr 2;47(4):403-409. Epub 2018 Mar 2.
    Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK.
    Background: We have evaluated the rationale of existing grading and staging schemes of oral submucous fibrosis (OSMF) based on how they are categorized. A novel classification and staging scheme is proposed.

    Methods: A total of 300 OSMF patients were evaluated for agreement between functional, clinical, and histopathological staging. Read More

    Oral potentially malignant disorders: risk of progression to malignancy.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Dec 29. Epub 2017 Dec 29.
    UWA Dental School, The University of Western Australia, Nedlands, Australia.
    Oral potentially malignant disorders (OPMDs) have a statistically increased risk of progressing to cancer, but the risk varies according to a range of patient- or lesion-related factors. It is difficult to predict the risk of progression in any individual patient, and the clinician must make a judgment based on assessment of each case. The most commonly encountered OPMD is leukoplakia, but others, including lichen planus, oral submucous fibrosis, and erythroplakia, may also be seen. Read More

    Myofibroblasts: Master of disguise.
    J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):462-463
    Department of Oral and Maxillofacial Pathology, St. Joseph Dental College, Eluru, Andhra Pradesh, India.
    Myofibroblasts are the unique population of smooth muscle-like fibroblasts. These cells have a role in growth factors secretion, matrix deposition and degradation. Thereby, myofibroblast contributes in both human physiology and pathology. Read More

    Evaluation of role of trace elements in oral submucous fibrosis patients: A study on Gujarati population.
    J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):455
    Department of Oral Medicine and Radiology, Ahmedabad Dental College and Hospital, Ahmedabad, Gujarat, India.
    Introduction: Oral submucous fibrosis (OSMF), a precancerous condition, is highly prevalent in the Indian subcontinent. Among many trace elements, copper and iron are required for the functioning of numerous enzymes. The biochemical alterations of these trace elements in the serum of patients with premalignant conditions can help in determining the staging of the disease, its appropriate treatment and as an indicator for prognosis. Read More

    Quantitative and qualitative assessment of argyrophilic nucleolar organizer regions in normal, premalignant and malignant oral lesions.
    J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):360-366
    Department of Oral Pathology, College of Dental Sciences and Research Bopal Dental College, Ahmedabad, Gujarat, India.
    Aim: The aim of the study was to assess the cell proliferation and biologic aggressiveness of the lesions by evaluating the significance of number and dispersal pattern of Argyrophillic Nucleolar organizing Regions (AgNORs) using silver colloid technique in normal mucosa, premalignant and malignant lesions.

    Settings And Design: In-vitro study, lab setting.

    Methods And Material: The study sample consisted of five groups each with a sample size of 10 and a control group. Read More

    Oral submucous fibrosis: Newer proposed classification with critical updates in pathogenesis and management strategies.
    Natl J Maxillofac Surg 2017 Jul-Dec;8(2):89-94
    Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, India.
    Oral submucous fibrosis (OSMF) is an oral precancerous condition characterized by inflammation and progressive fibrosis of the submucosal tissues resulting in marked rigidity and trismus. OSMF still remains a dilemma to the clinicians due to elusive pathogenesis and less well-defined classification systems. Over the years, many classification systems have been documented in medical literature based on clinical, histopathological, or functional aspects. Read More

    Risk analysis of malignant potential of oral verrucous hyperplasia: A follow-up study of 269 patients and copy number variation analysis.
    Head Neck 2018 May 29;40(5):1046-1056. Epub 2018 Jan 29.
    Graduate Institute of Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
    Background: Oral verrucous hyperplasia is commonly observed in the oral cavity of betel quid chewers and is a potential malignant disorder. However, the prognostic factors and genetic alterations of oral verrucous hyperplasia are unclear.

    Methods: We calculate the survival rate and prognostic factors using a Kaplan-Meier analysis and Cox proportional hazards regression model. Read More

    Versatility of Modified Nasolabial Flap in Oral and Maxillofacial Surgery.
    Arch Craniofac Surg 2017 Dec 23;18(4):243-248. Epub 2017 Dec 23.
    Department of Oral & Maxillofacial Surgery, Sri Aurobindo College of Dentistry, Indore, India.
    Background: To evaluate the versatility and reach of modified nasolabial flap used in reconstruction of defects created in and around the oral cavity.

    Methods: A total number of 20 cases were selected. Out of which 13 were males and 7 females. Read More

    Hinokitiol ablates myofibroblast activation in precancerous oral submucous fibrosis by targeting Snail.
    Environ Toxicol 2018 Apr 12;33(4):454-462. Epub 2018 Jan 12.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
    Oral submucous fibrosis (OSF) is a precancerous condition with symptoms of limited mouth opening and areca nut chewing habit has been implicated in its pathogenesis. Hinokitiol, a natural tropolone derived from Chamacyparis taiwanensis, has been reported to improve oral lichen planus and inhibit various cancer cells. Here, we showed that hinokitiol reduced the myofibroblast activities in fBMFs and prevented the arecoline-induced transdifferentiation. Read More

    Immunohistochemical Expression Of Ezrin In Oral Potentially Malignant Disorders-A Descriptive Study.
    J Pharm Bioallied Sci 2017 Nov;9(Suppl 1):S205-S210
    Department of Oral Pathology and Microbiology, Saveetha Dental College, Saveetha University, Chennai, Tamil Nadu, India.
    Introduction: Ezrin, also known as cytovillin, is a member of the ERM family of protein. Ezrin cross-links actin filament with the plasma membrane. They are involved in the formation of microvilli, cell-cell adhesion, maintenance of cell shape, cell motility, and membrane trafficking. Read More

    Comparative Evaluation of Serum Lipid Profile in Patients with Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma with that of Control Subjects: A Case Control Study.
    J Pharm Bioallied Sci 2017 Nov;9(Suppl 1):S191-S196
    Department of Conservative Dentistry and Endodontics, Vinayaka Missions Sankarachariyar Dental College, Salem, Tamil Nadu, India.
    Aim: The aim of the study was to evaluate the serum lipid profile among untreated oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSMF) patients.

    Materials And Methods: This study was done in three groups of patients - OSMF, OSCC, and control. There are twenty participants in each group. Read More

    Prevalence of Oral Mucosal Lesions among Dental Patients with Mixed Habits in Salem District - A Study.
    J Pharm Bioallied Sci 2017 Nov;9(Suppl 1):S55-S67
    Department of Oral Medicine, Vinayaka Missions Sankarachariyar Dental College, Salem, Tamil Nadu, India.
    Background: The practice of betel nut chewing with or without tobacco is still practiced in south india, salem inspite of its harmful effects.

    Methodology: 200 Patients visiting the outpatient department, Oral medicine and radiology from Aug 2015 to Aug 2016.

    Result And Conclusion: In our study, 3 women were exclusively churut smokers. Read More

    Development of a mouse model of arecoline-induced oral mucosal fibrosis.
    Asian Pac J Trop Med 2017 Dec 29;10(12):1177-1184. Epub 2017 Oct 29.
    Department of Oral Medicine, Haikou City People's Hospital, Haikou 570100, China.
    Objective: To develop a BALB/c mouse model of oral submucous fibrosis (OSF) induced by arecoline and to exhibit an accumulation of collagen and angiogenesis changes.

    Methods: BALB/c mice were randomly assigned to either the control (distilled water) or experimental group (arecoline) (n = 40). Eight mice from each group were sacrificed every 4 weeks since 8 weeks post treatment. Read More

    Velar morphological variants in oral submucous fibrosis: A comparative digital cephalometric study.
    Indian J Dent Res 2017 Nov-Dec;28(6):623-628
    Department of Oral Medicine and Radiology, Al-Badar Rural Dental College and Hospital, Gulbarga, Karnataka, India.
    Context: Soft palate (velar) plays a significant role in various important functions in the head and neck region. Its diverse morphology is implicated in a variety of diseases. Knowledge about the varied morphological pattern of soft palate in oral submucous fibrosis (OSMF) patients can give us a clear understanding about disease progress in the oropharyngeal region for a proper diagnosis and also help the maxillofacial surgeon in successful structural and functional corrections associated with this disorder. Read More

    LncRNA GAS5-AS1 inhibits myofibroblasts activities in oral submucous fibrosis.
    J Formos Med Assoc 2017 Dec 14. Epub 2017 Dec 14.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address:
    Background/purpose: Emerging research findings suggest that long non-coding RNAs (lncRNAs) are key regulators to fibrosis formation. Nevertheless, the role of lncRNA GAS5-AS1 in the progression of precancerous oral submucous fibrosis (OSF) remains to be elucidated.

    Methods: Quantitative real-time PCR were used to examine the expression of GAS5-AS1 in OSF tissues. Read More

    Thioctic acid in oral submucous fibrosis (India's disease) - A better tomorrow.
    J Stomatol Oral Maxillofac Surg 2018 Apr 12;119(2):129-134. Epub 2017 Dec 12.
    Department of oral medicine and radiology, A. J. Institute of Dental Sciences, Mangalore, India. Electronic address:
    Oral submucous fibrosis (OSMF), because of its common occurrence in Indian population is known as India's disease. Regardless of diagnostic and therapeutic developments, oral potentially malignant disorders (PMD) and cancers are disseminating at a distressing rate. There is this prerequisite for unrelenting determination to find out apt treatment options so that malignant transformation may be prevented and more so the prevailing morbidity and mortality. Read More

    A Comparative Clinical Evaluation of the Buccal Fat Pad and Extended Nasolabial Flap in the Reconstruction of the Surgical Defect in Oral Submucous Fibrosis Patients.
    J Oral Maxillofac Surg 2018 Mar 21;76(3):676.e1-676.e5. Epub 2017 Nov 21.
    Self-employed, Department of Oral and Maxillofacial Surgery, Government College of Dentistry, Indore, India.
    Purpose: The aim of this study was to compare the efficacy of locally available nasolabial and buccal fat pad flaps for increasing postoperative mouth opening in the reconstruction of the defect created after fiberotomy in surgically treated cases of oral submucous fibrosis (OSMF).

    Materials And Methods: Of 32 patients selected for the study, 21 patients underwent closure of the surgical defect using the buccal fat pad (group 1) and 11 patients underwent closure of the surgical defect using a nasolabial flap (group 2). Histologically proven cases of OSMF with a mouth opening no larger than 25 mm were included in the study. Read More

    STRO-1 confers myofibroblast transdifferentiation in fibroblasts derived from oral submucous fibrosis.
    J Oral Pathol Med 2018 Mar 18;47(3):299-305. Epub 2017 Dec 18.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
    Background: STRO-1 is a mesenchymal cell marker present on all clonogenic stromal precursors. Current evidence has indicated that the pathogenesis of fibrotic changes may be mediated by stemness properties. The aim of this study was to investigate the role of STRO-1 in areca quid chewing-associated oral submucous fibrosis (OSF). Read More

    Micronucleus Assay: An Early Diagnostic Tool to Assess Genotoxic Changes in Patients with Tobacco Use, Oral Leukoplakia and Oral Submucous Fibrosis.
    J Clin Diagn Res 2017 Sep 1;11(9):ZC28-ZC32. Epub 2017 Sep 1.
    Medical Research Scientist, Jorhat Medical College and Hospital, Barbheta, Jorhat, Assam, India.
    Introduction: Micronuclei (MNi) are acentric chromatid or chromosome fragments produced via genetic damage through genotoxic agents contained in tobacco and betel nut. Evidently, the various Oral Potentially Malignant Disorders (OPMDs) like oral lichen Planus, oral leukoplakia and Oral Submucous Fibrosis (OSMF) demonstrate MNi, as a substantiation of genetic damage. As these changes can be easily appreciated in oral exfoliated cells, an exfoliated cell based MNi assay might be utilized as handy and non invasive biomonitoring tool for gauging the genetic damage and hence the propensity for malignant transformation in OPMDs. Read More

    Status of Serum and Salivary Ascorbic Acid in Oral Potentially Malignant Disorders and Oral Cancer.
    Indian J Med Paediatr Oncol 2017 Jul-Sep;38(3):306-310
    Department of Oral Medicine and Radiology, A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, Karnataka, India.
    Background And Aims: The aim of this study was to estimate the detoxification status of serum and saliva by assessing the serum and salivary Vitamin C in oral potentially malignant disorders and oral cancer.

    Subjects And Methods: A total of 90 subjects, 30 subjects with oral potentially malignant disorders, 30 subjects with oral cancer, and 30 healthy subjects (controls) were included in the study. Serum and saliva were collected and levels of Vitamin C were assessed. Read More

    Utility of superiorly based platysma myocutaneous flap for reconstruction of intraoral surgical defects: our experience.
    Oral Maxillofac Surg 2018 Mar 23;22(1):45-51. Epub 2017 Nov 23.
    Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Nagpur, 440024, India.
    Purpose: Various surgical modalities have been advocated for the soft tissue reconstruction of oral cavity with variable results. This prospective study evaluates the utility of platysma myocutaneous flap (PMF) in the reconstruction of surgical defects followed by treatment of oral submucous fibrosis (OSMF) and oral squamous cell carcinoma (OSCC) in terms of healing and functional outcomes.

    Methods: In this prospective study, 47 patients with OSMF and 15 of OSCC were evaluated and selected for PMF reconstruction. Read More

    Oral submucous fibrosis: an etiological dilemma.
    J Exp Ther Oncol 2017 Nov;12(2):163-166
    Private practitioner, Indore. Madhya Pradesh, India.
    Objective: Oral Submucous Fibrosis (OSF), is a well-recognized, oral potentially malignant disorder predominantly affecting the South- Asian countries. OSF causes unique generalized fibrosis of the submucosal oral soft tissues, resulting in marked rigidity of the oral mucosa leading to progressive inability to open the mouth, rigidity of lips and difficulty in protruding the tongue. In this review we have discussed the multifactorial etiology of this potentially malignant disorder, including Chillies, Nutritional Deficiencies, Inducible nitric oxide synthsis (iNOS), genetic and immunological predisposition; and most importantly the role of areca nut and the effect of copper content in it. Read More

    Raman exfoliative cytology for oral precancer diagnosis.
    J Biomed Opt 2017 Nov;22(11):1-12
    Tata Memorial Center, Advanced Center for Treatment, Research and Education in Cancer, Chilakapati L, India.
    Oral premalignant lesions (OPLs) such as leukoplakia, erythroplakia, and oral submucous fibrosis, often precede oral cancer. Screening and management of these premalignant conditions can improve prognosis. Raman spectroscopy has previously demonstrated potential in the diagnosis of oral premalignant conditions (in vivo), detected viral infection, and identified cancer in both oral and cervical exfoliated cells (ex vivo). Read More

    Glabridin inhibits the activation of myofibroblasts in human fibrotic buccal mucosal fibroblasts through TGF-β/smad signaling.
    Environ Toxicol 2018 Feb 9;33(2):248-255. Epub 2017 Nov 9.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
    Oral submucous fibrosis (OSF) has been recognized as one of the oral potentially malignant disorders. Areca nut chewing is implicated in this pathological fibrosis, and it causes chronic inflammation and persistent activation of myofibroblasts. As yet, existing treatments only provide temporary symptomatic relief and there is a lack of an effective intervention to cure OSF. Read More

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