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    1171 results match your criteria Oral Submucous Fibrosis

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    Raman exfoliative cytology for oral precancer diagnosis.
    J Biomed Opt 2017 Nov;22(11):1-12
    Tata Memorial Center, Advanced Center for Treatment, Research and Education in Cancer, Chilakapati L, India.
    Oral premalignant lesions (OPLs) such as leukoplakia, erythroplakia, and oral submucous fibrosis, often precede oral cancer. Screening and management of these premalignant conditions can improve prognosis. Raman spectroscopy has previously demonstrated potential in the diagnosis of oral premalignant conditions (in vivo), detected viral infection, and identified cancer in both oral and cervical exfoliated cells (ex vivo). Read More

    Glabridin inhibits the activation of myofibroblasts in human fibrotic buccal mucosal fibroblasts through TGF-β/smad signaling.
    Environ Toxicol 2017 Nov 9. Epub 2017 Nov 9.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
    Oral submucous fibrosis (OSF) has been recognized as one of the oral potentially malignant disorders. Areca nut chewing is implicated in this pathological fibrosis, and it causes chronic inflammation and persistent activation of myofibroblasts. As yet, existing treatments only provide temporary symptomatic relief and there is a lack of an effective intervention to cure OSF. Read More

    Expression of β1integrin in normal epithelium, oral submucous fibrosis and oral squamous cell carcinoma.
    Pathol Res Pract 2017 Oct 26. Epub 2017 Oct 26.
    Department of Oral and Maxillofacial Pathology, Rajah Muthaih Dental College and Hospital, Annamalai University, Annamalai Nagar, Chidhambaram, Tamil Nadu, India. Electronic address:
    Introduction And Aims: The possible reason suggested for epithelial atrophy in oral submucous fibrosis (OSMF) is ischemia. Dysregulation in the epithelial proliferation and maturation is also thought to be a cause. The β1 integrin identifies the oral epithelial stem cells. Read More

    Evaluation of myofibroblasts in oral submucous fibrosis and oral squamous cell carcinoma: The pathogenesis and correlation.
    Dent Res J (Isfahan) 2017 Sep-Oct;14(5):314-320
    Department of Oral Pathology, Kanti Devi Dental College, Mathura, Uttar Pradesh, India.
    Background: Oral submucous fibrosis (OSMF) is a chronic debilitating disease of the oral cavity having premalignant potential and unclear pathogenesis. Recently, myofibroblast has been postulated to play an important role in its pathogenesis and in the process of carcinogenesis. The purpose of this study was to evaluate and compare the presence of myofibroblasts in normal mucosa, different grades of OSMF, and oral squamous cell carcinoma (OSCC). Read More

    PTMA, a new identified autoantigen for oral submucous fibrosis, regulates oral submucous fibroblast proliferation and extracellular matrix.
    Oncotarget 2017 Sep 24;8(43):74806-74819. Epub 2017 Aug 24.
    Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha 410078, China.
    Oral submucous fibrosis (OSF) is a chronic, insidious disease. The presence of autoantibodies in sera of OSF patients is the most characteristic and direct evidence of OSF being an autoimmune disease. To identify the specific autoantigens which could contribute to antibody production, the Human Proteome Microarrays composed of 19000 full-length unique proteins were employed. Read More

    Correlation of ultrasonographic measurements, histopathological grading, and clinical staging in oral submucous fibrosis.
    Indian J Dent Res 2017 Sep-Oct;28(5):476-481
    Department of Oral Medicine and Radiology, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, Maharashtra, India.
    Aims And Objectives: To evaluate the presence and thickness of submucosal fibrosis in oral submucous fibrosis (OSMF) patients ultrasonographically and to correlate these findings with the clinical stage and histological grade of OSMF.

    Materials And Methods: Forty participants (twenty cases and twenty controls) were included in the study. The patients diagnosed clinically as having OSMF and consented for biopsy were included in the cases, and completely healthy individuals with no habit history or oral lesions were included in the control group after matching the body mass index. Read More

    The role of halofuginone in fibrosis: more to be explored?
    J Leukoc Biol 2017 Oct 6. Epub 2017 Oct 6.
    Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China; and
    Fibrosis, which can be defined as an abnormal or excessive accumulation of extracellular matrix (ECM), particularly fibrillar collagens, is a key driver of progressive organ dysfunction in many inflammatory and metabolic diseases, including idiopathic pulmonary fibrosis (IPF), cirrhosis, nephropathy, and oral submucous fibrosis (OSF). It has been estimated to contribute to ∼45% of deaths in the developed world. Therefore, agents that target specific fibrotic pathways, with the consequence of slowing, arresting, or even reversing the progression of tissue fibrogenesis, are urgently needed. Read More

    Inhibitory effect of GMI, an immunomodulatory protein from Ganoderma microsporum, on myofibroblast activity and proinflammatory cytokines in human fibrotic buccal mucosal fibroblasts.
    Environ Toxicol 2017 Oct 6. Epub 2017 Oct 6.
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
    Oral submucous fibrosis (OSF) has been indicated as one of the oral potentially malignant disorders. Epidemiological studies have attributed this pathological fibrosis to the habit of areca nuts chewing, which causes chronic inflammation and persistent activation of myofibroblasts in the oral cavity. Hence, it is crucial to find an effective intervention to ameliorate inflammation in order to prevent the malignant progression of OSF. Read More

    Identification of over expressed proteins in Oral Submucous Fibrosis by proteomic analysis.
    J Cell Biochem 2017 Oct 5. Epub 2017 Oct 5.
    Molecular Genetics Division, CSIR- Indian Institute of Chemical Biology, Kolkata-700 032, India.
    Early detection and identification of oral pre-malignancy or malignancy help in management of the disease and improve survival rates. Oral submucous fibrosis (OSMF) is a major threat to public health worldwide and especially in Southeast Asian countries. Identification of biomarkers is a necessary step towards early diagnosis and treatment. Read More

    Bilateral Submental Flap: An Innovative Modification.
    J Craniofac Surg 2017 Nov;28(8):e786-e788
    Maharashtra, India.
    Early management of premalignant lesions like oral submucous fibrosis cannot be underestimated in context of prevention and control of oral malignancies. Soft tissue reconstruction of the oral cavity and face is a complex undertaking. Several flaps local and distant as well as microvascular are available, each with their pros and cons. Read More

    Assessment of anxiety, depression, and serum cortisol level in oral submucous fibrosis patients: A controlled clinical trial.
    Eur J Dent 2017 Jul-Sep;11(3):293-298
    Department of Oral Medicine and Radiology, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, India.
    Objective: The aim of this study was to assess the anxiety, depression, and serum cortisol level in OSMF patients.

    Materials And Methods: This cross-sectional study was conducted in the Outpatient Department of Oral Medicine and Radiology, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India. Age- and gender-matched 105 patients were divided into three equal groups as follows: Group 1 - those with areca nut chewing habits and OSMF, Group 2 - those with areca nut chewing habits but no OSMF, and Group 3- those without areca nut chewing habits and without OSMF. Read More

    Validation of immunoexpression of tenascin-C in oral precancerous and cancerous tissues using ImageJ analysis with novel immunohistochemistry profiler plugin: An immunohistochemical quantitative analysis.
    J Oral Maxillofac Pathol 2017 May-Aug;21(2):211-217
    Department of Oral Pathology and Microbiology, KLE University, KLE VK Institute of Dental Sciences, Belgaum, Karnataka, India.
    Background: Immunohistochemistry (IHC) is a molecular technique that has grown tremendously over the years. However, the assessment is only qualitative which is subjective and causes errors. Due to this limitation, several excellent markers have not gained importance and reached clinical trials. Read More

    Prosthetic rehabilitation of oral submucous fibrosis patients: A systematic review of published case reports and case series.
    PLoS One 2017 6;12(9):e0184041. Epub 2017 Sep 6.
    Department of Prosthodontics & Dental Materials and Dean, School of Dental Medicine, University of Siena, Italy.
    Background: Oral submucous fibrosis (OSF) is an insidious chronic condition characterized by restricted mouth opening. Prosthetic rehabilitation is challenging for OSF patients as obtaining a good impression requires adequate mouth opening. The aim of the present review is to systematically present the data from case reports published in the English-language literature. Read More

    An update on studies on etiological factors, disease progression, and malignant transformation in oral submucous fibrosis.
    J Cancer Res Ther 2017 Jul-Sep;13(3):399-405
    Department of Oral and Maxillofacial Pathology, Pacific Dental College and Hospital, Udaipur, Rajasthan, India.
    Worldwide estimates of oral submucous fibrosis (OSMF) show a confinement to Indians and Southeast Asians. In India, the prevalence of OSMF has increased over the past four decades from 0.03% to 6. Read More

    Effect of Frequency and Duration of Tobacco Use on Oral Mucosal Lesions – A Cross-Sectional Study among Tobacco Users in Hyderabad, India
    Asian Pac J Cancer Prev 2017 08 27;18(8):2233-2238. Epub 2017 Aug 27.
    Purpose: Tobacco use is one of the most important risk factors for the development of oral mucosal lesions including oral pre-cancer and cancer. The type and location of the lesion varies with the type of tobacco used, the way it is used, and the frequency and duration of use. Hence, the present study aimed to determine the effect of frequency and duration of tobacco use on oral mucosal lesions among tobacco users in Hyderabad city. Read More

    Total Serum Protein Estimation and Its Correlation with Clinical and Histopathological Grading using Masson's Trichrome Stain in Patients of Oral Submucous Fibrosis.
    Contemp Clin Dent 2017 Apr-Jun;8(2):286-292
    Department of Oral and Maxillofacial Pathology and Microbiology, D.Y. Patil University, School of Dentistry, Nerul, Navi Mumbai, Maharashtra, India.
    Objectives: Oral submucous fibrosis (OSMF) caused by dense deposition of collagen fibers which is a protein. There is a plethora of research to evaluate degree of collagen deposition using various simple histochemical techniques, but its correlation with total serum protein (TSP) level has not been explored so far.

    Materials And Methods: This case-control study comprised total forty samples with thirty cases of OSMF and ten cases were selected as control group, divided into four groups as per Lai et al. Read More

    Evaluation of Oral Pentoxifylline in the Management of Oral Submucous Fibrosis - An Ultrasonographic Study.
    Contemp Clin Dent 2017 Apr-Jun;8(2):200-204
    Department of Oral Medicine and Radiology, Tamil Nadu Government Dental College and Hospital, Chennai, Tamil Nadu, India.
    Aim And Objective: To evaluate the therapeutic efficacy of oral pentoxifylline in the treatment of oral submucous fibrosis (OSMF) patients by assessing the clinical symptoms such as burning sensation, mouth opening, and submucosal layer thickness and echogenicity using ultrasonography, both pre- and post-operatively.

    Materials And Methods: Thirty study subjects were included in the study and divided into two groups in single-blind randomized manner, oral pentoxifylline and dexamethasone group. Burning sensation, mouth opening, ultrasonographic submucosal thickness, and echogenicity were recorded both pre- and post-operatively. Read More

    Cyclophilin A was revealed as a candidate marker for human oral submucous fibrosis by proteomic analysis.
    Cancer Biomark 2017 Sep;20(3):345-356
    State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China.
    Oral submucous fibrosis (OSF) is a chronic insidious disease which predisposes to oral cancer. Understanding the molecular markers for OSF is critical for diagnosis and treatment of oral cancer. In this study, the proteins expression profile of OSF tissues was compared to normal mucous tissues by 2 dimensional electrophoresis (2-DE). Read More

    Serum-based diagnostic prediction of oral submucous fibrosis using FTIR spectrometry.
    Spectrochim Acta A Mol Biomol Spectrosc 2018 Jan 8;189:322-329. Epub 2017 Aug 8.
    School of Medical Science & Technology, Indian Institute of Technology, Kharagpur, India. Electronic address:
    Oral submucous fibrosis (OSF) is found to have the highest malignant potentiality among all other pre-cancerous lesions. However, its detection prior to tissue biopsy can be challenging in clinics. Moreover, biopsy examination is invasive and painful. Read More

    Identification of α-enolase as a prognostic and diagnostic precancer biomarker in oral submucous fibrosis.
    J Clin Pathol 2017 Aug 18. Epub 2017 Aug 18.
    School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, India.
    Aims: Diagnostic ambiguities regarding the malignant potentiality of oral submucous fibrosis (OSF), an oral precancerous condition having dysplastic and non-dysplastic isoforms are the major failure for early intervention of oral squamous cell carcinoma (OSCC) patients. Our goal is to identify proteomic signatures from biopsies that can be used as precancer diagnostic marker for patient suffering from OSF.

    Methods: The high throughput techniques adopting de novo peptide sequencing (1D SDS-PAGE coupled nanoLC MALDI tandem mass spectrometry (MS/MS)-based peptide mass fingerprint), immunohistochemistry (IHC), Western blot (WB) and real-time PCR (RT-PCR) analysis are considered for such biomarker identification and multilevel validations. Read More

    Tobacco Abuse and Associated Oral Lesions among Interstate Migrant Construction Workers.
    J Contemp Dent Pract 2017 Aug 1;18(8):695-699. Epub 2017 Aug 1.
    Department of Oral Pathology and Microbiology, Kannur Dental College, Kannur, Kerala, India.
    Aim: The present study was conducted to assess the prevalence of tobacco use and associated oral mucosal lesions among construction workers of Cochin, Kerala, India.

    Materials And Methods: A cross-sectional study was carried at various construction sites of Cochin and 2,163 workers were selected using multistage sampling method and were interviewed and examined. Information regarding demographic details, form, type, frequency of tobacco use, earlier attempt to quit, and willingness to quit tobacco use was obtained using predesigned questionnaire. Read More

    [Expression of PTPRZ1 in oral squamous cell carcinoma originated from oral submucous fibrosis and its clinical significance].
    Shanghai Kou Qiang Yi Xue 2017 Apr;26(2):198-203
    Department of Oral and Maxillofacial Surgery, Affiliated Haikou Hospital of Xiangya Medical College. Haikou 570208, Hainan Province, China.
    Purpose: This study was aimed to detect the expression of PTPRZ1 in oral squamous cell carcinoma (OSCC) originated from oral submucous fibrosis (OSF), and discuss its role in the development and progression of OSCC originating from OSF as well as its clinical significance.

    Methods: Immunohistochemisty (IHC) and Western blot (WB) for the expression and distribution of PTPRZ1 were carried out in 36 cases of OSF transforming into OSCC, 23 cases of OSCC and 21 cases of healthy controls. The data were analyzed by Chi-square test using SPSS 21. Read More

    [Methods and effects of injection of salvianolic acid B combined with triamcinolone acetonide in the treatment of oral submucous fibrosis].
    Shanghai Kou Qiang Yi Xue 2017 Apr;26(2):188-192
    Department of Oncology, the Third Xiangya Hospital, Central South University. Changsha 410013, Hunan Province, China.
    Purpose: To introduce the methods of triamcinolone acetonide (TA) and salvianolic acid B(SA-B) intralesional injection in the treatment of oral submucous fibrosis and evaluate the treatment effects.

    Methods: TA combined with SA-B were consecutively applied intralesionally 1 time weekly for 30 times. The technique of intralesional injection was that syringe needle be emptied into submucous tissues 1 cm posterior to the corner of oral cavity running from the front to retromolar area by pushing the injection, then the syringe needle retained to the original point and upward from the front to retromolar area by pushing the injection, finally the syringe needle returned to the starting point and downward from the front to retromolar area by pushing the injection. Read More

    Textural pattern classification for oral squamous cell carcinoma.
    J Microsc 2017 Aug 2. Epub 2017 Aug 2.
    Dr. B. Borooah Cancer Research Institute, Guwahati, Assam, India.
    Despite being an area of cancer with highest worldwide incidence, oral cancer yet remains to be widely researched. Studies on computer-aided analysis of pathological slides of oral cancer contribute a lot to the diagnosis and treatment of the disease. Some researches in this direction have been carried out on oral submucous fibrosis. Read More

    Impact of oral potentially malignant disorders on quality of life.
    J Oral Pathol Med 2017 Aug 2. Epub 2017 Aug 2.
    Menzies Health Institute Queensland and School of Dentistry and Oral Health, Griffith University, Qld, Australia.
    Background: Oral potentially malignant disorders (OPMDs) could have a significant psychological impact on patients, principally because of the unknown risk of malignant transformation, while the physical and functional impairments could differ. This study aimed to assess the impact of three different OPMDs and their disease stages on the quality of life (QoL) of affected patients.

    Methods: Oral leukoplakia (OL), oral lichen planus (OLP) and oral submucous fibrosis (OSF) patients who were undergoing treatment at an oral medicine clinic of a dental teaching hospital in India were the study population. Read More

    Efficacy of oral colchicine with intralesional hyaluronidase or triamcinolone acetonide in the Grade II oral submucous fibrosis.
    Natl J Maxillofac Surg 2017 Jan-Jun;8(1):50-54
    Department of Oral and Maxillofacial Surgery, King George's Medical University, Lucknow, Uttar Pradesh, India.
    Background And Objectives: Oral submucous fibrosis (OSMF) is a potentially malignant disorder of oral mucosa affecting mainly population in South and Southeast Asia. The aim of this study is to compare the effectiveness of oral colchicine with intralesional injection of hyaluronidase or injection triamcinolone acetonide in patients with Grade II OSMF.

    Materials And Methods: The study included thirty patients of clinically diagnosed Grade II OSMF. Read More

    Evaluating the efficacy of pentoxifylline in the treatment of oral submucous fibrosis: A meta-analysis.
    Oral Dis 2017 Jul 24. Epub 2017 Jul 24.
    State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
    Oral submucous fibrosis (OSMF), a potentially malignant oral cavity disorder that causes speech and mastication problems, lacks an established treatment regimen; moreover, no treatment can effectively reverse the course of OSMF. A meta-analysis was conducted to investigate the efficacy of the peripheral vasodilator, pentoxifylline, in the treatment of OSMF. We searched five different databases for studies meeting our eligibility criteria (up to June 30, 2017). Read More

    Oral submucous fibrosis in a school-going Indian adolescent boy.
    Int J Adolesc Med Health 2017 Jul 21. Epub 2017 Jul 21.
    .
    A 14-year-old boy presented to our hospital with a chief complaint of difficulty in opening his mouth and a burning sensation on eating spicy food. The oral mucosa showed generalized diffused blanching and he was unable to protrude his tongue. For 6 years he had habitually chewed gutkha - a mixture of betel nut and tobacco for several minutes a day. Read More

    Arecoline activates latent transforming growth factor β1 via mitochondrial reactive oxygen species in buccal fibroblasts: Suppression by epigallocatechin-3-gallate.
    J Formos Med Assoc 2017 Jul 15. Epub 2017 Jul 15.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan. Electronic address:
    Background/purpose: Oral submucous fibrosis (OSF) is a premalignant condition caused by the chewing of areca nut (AN). Transforming growth factor β (TGFβ) plays a central role in the pathogenesis of OSF. Connective tissue growth factor (CTGF or CCN2) and early growth response-1 (Egr-1) are important mediators in the fibrotic response to TGFβ in several fibrotic disorders including OSF. Read More

    Comparison of Extended Nasolabial Flap Versus Buccal Fat Pad Graft in the Surgical Management of Oral Submucous Fibrosis: A Prospective Pilot Study.
    J Maxillofac Oral Surg 2017 Sep 22;16(3):312-321. Epub 2016 Oct 22.
    Department of Oral and Maxillofacial Surgery, Saveetha Dental College and Hospital, Chennai, Tamil Nadu India.
    Aim: To evaluate the application of extended nasolabial flap versus buccal fat pad graft in the surgical management of oral submucous fibrosis.

    Settings And Design: This prospective study was carried out in the Department of Oral and Maxillofacial Surgery, Tamil Nadu Government Dental College and Hospital, Chennai.

    Material And Methods: A total of 8 patients (6 men and 2 women) with age range from 21 to 65 years were selected for study. Read More

    Ki67, CD105, and α-SMA expressions better relate the binary oral epithelial dysplasia grading system of World Health Organization.
    J Oral Pathol Med 2017 Nov 25;46(10):921-927. Epub 2017 Jul 25.
    Department of Oral Pathology and Microbiology, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (M), Wardha, Maharashtra, India.
    Background: The binary system of oral epithelial dysplasia (OED) has never been investigated with reference to the carcinogenesis-related biomarkers. Hence, Ki67, CD105, and α-SMA immune-expressions were studied in oral potentially malignant disorders (OPMDs) to assess their relationship with the binary OED grading system of World Health Organization.

    Methods: The study was carried out on paraffin-embedded tissues of 30 normal oral mucosa (NOM) and 140 OPMD cases. Read More

    Early Stage Oral Submucous Fibrosis is Characterized by Increased Vascularity as Opposed to Advanced Stages.
    J Clin Diagn Res 2017 May 1;11(5):ZC92-ZC96. Epub 2017 May 1.
    Associate Professor, Department of Oral and Maxillofacial Pathology and Microbiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.
    Introduction: The degree of vascularity of the diseased mucosa in Oral Submucous Fibrosis (OSMF) has always been a matter of debate with conflicting results. Knowledge of this aspect is important to understand pathogenesis of OSMF, which in future could be translated into therapeutic strategies.

    Aim: In the present study, attempt has been made to investigate parameters like Mean Vascular Density (MVD), Total Vascular Area (TVA) and Mean Vascular Area (MVA) using CD34 antibody. Read More

    Patterns of tobacco usage among subjects with potentially malignant oral lesions or conditions in Chennai city: A comparative study.
    J Cancer Res Ther 2017 Apr-Jun;13(2):230-234
    Department of Public Health Dentistry, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India.
    Objective: To determine the patterns of tobacco usage among subjects with potentially malignant oral lesions or conditions through a comparative study design.

    Methods: The study was carried out in a span of 2 months on a sample of 120 subjects; 60 in case group (30 subjects with leukoplakia and oral submucous fibrosis [OSMF], respectively) and 60 subjects in control group (30 current smokers and current chewers, respectively), attending the tobacco cessation clinic at a private dental college hospital in Chennai city. Demographic data, details of tobacco usage, and Fagerstrom nicotine dependence scores (FNTD) were recorded in a prevalidated tobacco cessation intake form. Read More

    Oral squamous cell carcinoma associated with oral submucous fibrosis have better oncologic outcome than those without.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Sep 4;124(3):225-230. Epub 2017 May 4.
    Consultant, MGM Dental College, Navi Mumbai, Maharashtra, India.
    Objective: Oral submucous fibrosis (OSMF) is a potentially malignant disorder associated with the use of areca nut, and is mainly seen in the parts of Southeast Asia and the Indian subcontinent. We hypothesized that oral cancers occurring in presence of OSMF are clinicopathologically a distinct entity.

    Study Design: We analyzed 289 treatment naïve patients of oral cancer. Read More

    Effect of health education on awareness about oral cancer and oral self-examination.
    J Educ Health Promot 2017 5;6:27. Epub 2017 May 5.
    Department of Community Medicine, School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    Context: Oral cancer is preceded by visible changes in the oral mucosa. These lesions can be detected by oral self-examination, but awareness about oral cancer is still low in developing countries.

    Aim: To evaluate the effect of health education on awareness about oral cancer and oral self-examination. Read More

    Effectiveness of Osteopathic Therapy in the Treatment of Oral Submucous Fibrosis.
    Contemp Clin Dent 2017 Jan-Mar;8(1):145-147
    Department of Oral Medicine and Radiology, Maharishi Markandeshwar College of Dental Sciences and Research, Maharishi Markandeshwar University, Ambala, Haryana, India.
    Oral submucous fibrosis (OSMF) is a chronic progressive debilitating disease of oral cavity leading to the stiffness of oral mucosa, burning and trismus resulting in marked rigidity, and an inability to open the mouth. As the medical treatment of OSMF is yet not standardized, the purpose of the present case study was to explore the effectiveness of osteopathic manipulative treatment (OMT) in patients with OSMF. A 30-year-old male presented with a complaint of reduced mouth opening with burning sensation while eating spicy food for 4 years. Read More

    Tanshinone Suppresses Arecoline-Induced Epithelial-Mesenchymal Transition in Oral Submucous Fibrosis By Epigenetically Reactivating the p53 Pathway.
    Oncol Res 2017 May 21. Epub 2017 May 21.
    Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
    Oral submucous fibrosis (OSF) induced by the chewing of areca nut has been considered as a precancerous lesion with a higher probability of developing oral squamous cell carcinoma. Tanshinone (TSN) is the main component extracted from Salvia miltiorrhiza, a traditional Chinese medicine, which was found to have diverse pharmacological effects such as anti-inflammatory and anti-tumor effects. In current study, we aim to identify inhibitory effects and the underlying mechanism of Tanshinone on OSF progress. Read More

    Determination of role of ceruloplasmin in oral potentially malignant disorders and oral malignancy-A cross-sectional study.
    Oral Dis 2017 Nov 13;23(8):1066-1071. Epub 2017 Jun 13.
    Department of Oral Medicine and Radiology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth University, Vadodara, India.
    Objectives: In the process of carcinogenesis, lipid peroxidation and increased oxidative stress lead to changes in certain antioxidants. This study was aimed to assess and co-relate serum levels of ceruloplasmin in oral premalignancies and oral cancer so as to gauge its possible association with the process of carcinogenesis and to determine its role as tumor marker.

    Material And Methods: The study population comprised of 300 participants, equally divided into six study groups, that is, oral submucous fibrosis (OSMF), oral leukoplakia (OL), nicotina stomatitis (NS), oral malignancy (OM), controls (C), and healthy controls (HC); 5 ml of blood was collected from ante cubital vein from each participant. Read More

    Paediatric oral submucous fibrosis - The neglected pre-malignancy of childhood.
    Int J Pediatr Otorhinolaryngol 2017 Jun 28;97:55-60. Epub 2017 Mar 28.
    Jaypee Hospital, Noida 201301, India.
    Oral submucous fibrosis in children is one of the devastating consequences of arecanut addiction in children. Arecanut is the fourth commonest psychoactive agents used worldwide. However, regrettably, unlike other addictions like tobacco and alcohol, its use in children has become socially acceptable atleast in a few countries. Read More

    Photodynamic treatment outcomes of potentially-malignant lesions and malignancies of the head and neck region: A systematic review.
    J Investig Clin Dent 2017 May 8. Epub 2017 May 8.
    Department of Conservative and Endodontics, HSRS Dental College and Hospital, Hingoli, Maharashtra, India.
    Aim: The aim of the present study was to systematically review the efficacy of photodynamic therapy (PDT) in the management of oral potentially-malignant disorders (PMDS) and head and neck squamous cell carcinoma (HNSCC).

    Methods: From 1985 to 2015, PubMed/Medline, Google Scholar, EMBASE, and ISI Web of Knowledge were searched using different combinations of the following key words: PDT, oral precancer, leukoplakia, erythroplakia, erythroleukoplakia, verrucous hyperplasia, oral submucous fibrosis, and HNSCC. Review articles, experimental studies, case reports, commentaries, letters to the editor, unpublished articles, and articles published in languages other than English were excluded. Read More

    Oral submucous fibrosis: A quantitative assessment of serum malondialdehyde, superoxide dismutase and correlation with clinical staging.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):41-45
    Department of Oral Pathology, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
    Background: Oral submucous fibrosis (OSMF) is a progressive disorder affecting the oral mucosa. OSMF predominantly seen in South-east Asian countries. There are some biochemicals parameters which are modify in oral submucous fibrosis; this alteration can be used as a tool for diseases progress and avert malignant transformation. Read More

    Redefining epithelial characterization in oral submucous fibrosis using morphometric analysis.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):36-40
    Department of Oral and Maxillofacial Pathology and Microbiology, ITS Centre for Dental Studies and Research, Ghaziabad, Uttar Pradesh, India.
    Background: Oral submucous fibrosis (OSMF) is a chronic oral mucosal disease characterized by progressive deposition of collagen in subepithelial connective tissue and epithelial atrophy. The present study was conducted to evaluate the changes in epithelial thickness and cellular and nuclear morphometric characteristics of parabasal and spinous compartments of the epithelium in various stages of OSMF in comparison to normal epithelium.

    Materials And Methods: Sample included 30 cases of OSMF of various stages and five cases of normal buccal mucosa. Read More

    Estimation of hemoglobin, serum iron, total iron-binding capacity and serum ferritin levels in oral submucous fibrosis: A clinicopathological study.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):30-35
    Department of Oral and Maxillofacial Pathology, Mamata Dental College and Hospital, Khammam, Telangana, India.
    Introduction: Oral submucous fibrosis (OSMF) is also considered as an Asian version of sideropenic dysphagia, wherein chronic iron deficiency leads to mucosal susceptibility to irritants, such as chillies and areca nut products. Hemoglobin (Hb) levels, in particular, serum iron levels, are considered as biochemical indicators for nutritional assessment. Serum iron content can thus be a predictor for the progression of the condition, and there appears to be an association between serum iron content and oral carcinogenesis. Read More

    "Clinicobiochemical evaluation of turmeric with black pepper and Nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study"-a commentary.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 06 16;123(6):737. Epub 2017 Mar 16.
    Assistant Professor, Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, India.

    Activation of transforming growth factor-β1 by thrombin via integrins αvβ1, αvβ3, and αvβ5 in buccal fibroblasts: Suppression by epigallocatechin-3-gallate.
    Head Neck 2017 Jul 2;39(7):1436-1445. Epub 2017 May 2.
    School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan.
    Background: Transforming growth factor-beta (TGF-β) plays a central role in the pathogenesis of oral submucous fibrosis (OSF). Thrombin is a key player in tissue repair, inflammation, and fibrosis after injury.

    Methods: Effects of thrombin on activated-TGF-β1 levels, Smad3 phosphorylation, and connective tissue growth factor (CTGF/CCN2) synthesis in primary human buccal mucosal fibroblasts (BMFs) were assessed by enzyme-linked immunosorbent assay or Western blot analysis. Read More

    Reply to: Details of the participants and medical intervention used in the study evaluating the effect of a mouth exercising device on burning sensation in oral submucous fibrosis.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 06 21;123(6):735-737. Epub 2017 Feb 21.
    Lecturer, Department of Orthodontics, Faculty of Dentistry, MAHSA University, Kuala Lumpur, Malaysia.

    Qualitative analysis of the impact of Oral Potentially Malignant Disorders on daily life activities.
    PLoS One 2017 14;12(4):e0175531. Epub 2017 Apr 14.
    Menzies Health Institute Queensland, Griffith University, Queensland, Australia.
    Objective: To evaluate the impact of Oral Potentially Malignant Disorders (OPMD) on daily life activities.

    Materials And Methods: Patients diagnosed with Oral Leukoplakia, Oral submucous fibrosis and Oral Lichen Planus attending the Oral Medicine clinic of Panineeya Institute of Dental Sciences & Research Centre, Hyderabad, India were invited to participate. Eighteen interviews and three focus groups were conducted in a non-clinical setting. Read More

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