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Gen Dent 2020 Jul-Aug;68(4):61-63

Down syndrome (DS), a genetic disorder caused by chromosome 21 trisomy, is characterized by intellectual disability, congenital malformations, craniofacial alterations, and dentofacial anomalies. Although some oral lesions have been reported in patients with DS, this is the first reported case of a pyogenic granuloma affecting the tongue of a patient with DS. A 20-year-old man presented with a well-demarcated nodular lesion on the right lateral border of the tongue. Read More

Gen Dent 2020 Jul-Aug;68(4):28-31

The conventional method of managing intraoral soft tissue overgrowth involves surgical excision using a scalpel under local anesthesia. These procedures are often associated with excessive bleeding that leads to complications. Now, minimally invasive methods such as laser excision are available for the management of intraoral soft tissue lesions. Read More

J Oral Maxillofac Pathol 2020 Jan-Apr;24(1):148-151. Epub 2020 May 8.

Department of Oral Pathology, MM College of Dental Sciences and Research, Mullana (Deemed to be University), Ambala, Haryana, India.

The presence of eosinophilic Toto bodies in oral lesions could be found in a variety of situations and sometime may present a challenge to the pathologist. We present three case reports where the oral biopsy was taken from the gingival region of a 30-year-old female, a 32-year-old male patient and another from the buccal mucosa of a 67-year-old male patient. Histopathologically, the three cases were finally diagnosed as pyogenic granuloma and moderately differentiated squamous cell carcinoma with the presence of clusters of Toto bodies in the upper spinous layer of stratified squamous epithelium. Read More

J Oral Maxillofac Pathol 2020 Jan-Apr;24(1):76-80. Epub 2020 May 8.

Department of Oral Pathology and Microbiology, Bareilly International University, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.

Context: Focal fibrous hyperplasia, peripheral ossifying fibroma, pyogenic granuloma, peripheral giant cell granuloma, giant cell fibroma and focal reactive overgrowth (FROGs) are one of the foremost numerous benign soft-tissue growths in the oral cavity. Chronic irritation or trauma is with identified as the causative aspect. It may develop up to few centimeters in diameter, pedunculated or sessile and may arise on the gingiva or buccal mucosa. Read More

Spec Care Dentist 2020 May 22;40(3):285-290. Epub 2020 May 22.

Department of Oral and Maxillofacial Surgery, Tokai University School of Medicine, Tokyo, Japan.

Aim: Tongue bites frequently occur during seizures in epilepsy patients. We report two cases of cognitively impaired Lennox-Gastaut syndrome patients with reactive lesions on the tongues.

Case Presentations: Case 1 was a 30-year-old man whose chief complaint was mouth pain. Read More

Clin Implant Dent Relat Res 2020 Jun 7;22(3):366-372. Epub 2020 May 7.

Oral Pathology Master Programme, Oral and Maxillofacial Pathology Unit, Dental Clinic Service, Department of Stomatology II, University of the Basque Country (UPV/EHU), Leioa, Spain.

Background: Peri-implantitis is the inflammatory process, which most commonly affects the therapy with dental implants. However, there are other reactive and neoplastic entities, mainly benign but also malignant, which also take place in the peri-implant mucosa. There is little information about the histopathological analysis of these peri-implant inflammatory diseases. Read More

Eplasty 2020 22;20:ic2. Epub 2020 Feb 22.

Department of Oral and Maxillofacial Surgery and Plastic Surgery.

J Dent Sci 2020 Mar 17;15(1):92-95. Epub 2019 Oct 17.

Division of Oral Pathology & Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Background/purpose: Oral metastatic carcinomas are rarely found in oral soft tissues. This study reported the clinicopathological features of 13 intraoral soft tissue metastatic carcinomas.

Materials And Methods: A total of 13 intraoral soft tissue metastatic carcinomas were included in this study. Read More

J Histotechnol 2020 Mar 10:1-7. Epub 2020 Mar 10.

Department of Oral Pathology and Microbiology, I.T.S Centre for Dental Studies and Research, Ghaziabad, India.

Head and neck connective tissue lesions may have diverse calcifications within the fibrous connective tissue stroma. The perplexity involved in the identification and determination of the nature or degree of calcification through routine hematoxylin and eosin (H&E) stains necessitates the usage of a specific, simple, and cost- and time-effective differential staining techniques. The aim of the present study was to develop criteria to distinguish bone formation from bone resorption using methylene blue-acid fuchsin (MB/AF) stain and the role of collagen fibers in the identification of stromal calcifications using polarizing microscopy with picrosirius red stain. Read More

Autops Case Rep 2020 Jan-Mar;10(1):e2019127. Epub 2019 Dec 13.

Sri Balaji Vidyapeeth University, Indira Gandhi Institute of Dental Sciences, Department of Oral Pathology and oral Microbiology. Puducherry, Puducherry, India.

Peripheral Ameloblastoma (PA) is a benign odontogenic tumor, arising from the cell rest of Serres, reduced enamel epithelium and basal cells of the surface epithelium. Peripheral ameloblastoma is a rare odontogenic neoplasm occurring commonly in the mandibular gingiva. PA clinically resembles other peripherally occurring lesions like pyogenic granuloma, peripheral ossifying fibroma, peripheral giant cell granuloma, and squamous papilloma. Read More

Acta Dermatovenerol Croat 2019 Dec;27(4):280-281

Luis Santiago, MD, Dermatology Department Centro Hospitalar e Universitário de Coimbra, Praceta Prof. Mota Pinto, 3000-075 Coimbra, Portugal;

Dear Editor, Orf, also called contagious ecthyma, contagious pustular dermatitis, sore mouth, or scabby mouth, is a highly contagious zoonotic disease which is caused by a double-stranded DNA virus, ORFV (Parapoxvirus genus of the family Poxviridae) (1). The infection is endemic to sheep and goats, and humans are infected either through direct transmission from active lesions on infected animals or through contact with fomites (2). Orf is an occupational hazard and the population at risk includes shepherds, butchers, farmers, wool shearers, and veterinarians (2,3). Read More

Rom J Morphol Embryol 2019 ;60(3):811-822

Department of Implantology, Removable Prosthesis, Dental Prosthesis Technology, Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, Iaşi, Romania;

Background: Gingival overgrowth refers to an increase in the size of the gingival tissue. The etiology varies, and is often a multi-factor issue; what may contribute to gingival enlargement are aspects, such as disease, local and systemic conditions and idiopathic factors. The aim of the present study is to analyze and to correlate the clinical, epidemiological, imaging and histopathological (HP) features of gingival overgrowth in northeastern Romanian population. Read More

Head Neck Pathol 2020 Jan 2. Epub 2020 Jan 2.

Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, 1395 Center Drive, Gainesville, FL, 32610, USA.

Verruciform xanthoma (VX) of the oral cavity is an uncommon, reactive lesion of unknown etiology. In this study, we present a large series of VX with analysis of demographics, clinical appearance, histologic presentation and extensive review of literature. To the best of our knowledge, this is the largest series of oral VX reported to date. Read More

Dent Traumatol 2019 Dec 23. Epub 2019 Dec 23.

Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia.

This paper reports a case of a labial pyogenic granuloma in the lower lip of a 15-year-old boy due to chronic trauma from the maxillary left central incisor. The case report is based on the CARE (CAse REport) Checklist developed by the Joanna Briggs Institute. A further aim is to present a mini-review about the link between labial pyogenic granuloma and trauma, through searching in three databases (MEDLINE, EMBASE, and Global Health) using a predefined search strategy and keywords. Read More

Iran J Otorhinolaryngol 2019 Nov;31(107):399-402

Department of Otorhinolaryngology, Krishna Institute of Medical Sciences Deemed To Be University, Karad, 415110; Maharashtra, India.

Introduction: Lobular capillary hemangioma (LCH) is caused by exuberant neovascular response to infection, local irritation (e.g., trauma), or hormonal influence (e. Read More

Case Rep Gastrointest Med 2019 29;2019:9869274. Epub 2019 Sep 29.

Division of Gastroenterology, St. Joseph's University Medical Center, New York Medical College, USA.

Pyogenic Granuloma (PG), also known as lobular capillary hemangioma, is usually seen as a polypoid red lesion found on the skin or the mucosal surface of the oral cavity. PG of the gastrointestinal tract is rare, in particular involving the esophagus, only 14 cases have been reported in the English literature. We present an 80-year-old male who underwent endoscopy for evaluation of dysphagia and was found to have a single, red, bilobed 10 mm polyp with adherent white exudate approximately 19 cm from the incisors. Read More

Intern Med 2020 Feb 15;59(4):501-505. Epub 2019 Oct 15.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan.

Pyogenic granuloma (PG) generally appears in the skin or oral cavity, but rarely occurs in the small intestine, where it can cause bleeding. To date, only 35 cases of small intestinal PG have been reported in the English literature. We retrospectively collected information from the clinical records of seven cases of small intestinal PG that were managed in our hospital and summarized the characteristics. Read More

J Drugs Dermatol 2019 Oct;18(10):1061-1062

To the Editor: An otherwise-healthy 27-year-old male patient presented with a 3-month history of an asymptomatic, non-bleeding, rapidly growing nodule, on his left upper vermilion lip. Read More

J Drugs Dermatol 2019 10;18(10):1006-1010

Pyogenic granuloma (PG) is an acquired vascular growth on the skin and mucous membranes. Even though PG is a benign tumor, treatment is required due to associated risk of ulceration and bleeding, cosmetic concerns, and the low likelihood of spontaneous regression. Treatment entails excisional surgery, cryotherapy, or electrocautery; recurrence however is a major problem. Read More

Clin Pract 2019 Aug 27;9(3):1179. Epub 2019 Aug 27.

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

Pyogenic granuloma is a non-neoplastic, exuberant, reactive lesion seen in response to local irritation or trauma caused by dental calculus, bacterial plaque, caries and restorations, with a strong predilection for the gingiva. It is among the frequently encountered oral lesions, occurring at a challenging oral site, the gingiva. Herein, we report a 71-year-old medically compromised Caucasian female who presented with a relatively large lobulated pyogenic granuloma on the buccal gingiva of the maxillary molar-premolar region. Read More

J Taibah Univ Med Sci 2019 Feb 4;14(1):95-98. Epub 2018 Dec 4.

Department of Oral Pathology, Kathmandu University School of Medical Sciences, Dhulikhel, Nepal.

Pyogenic granuloma is a non-neoplastic reactive lesion that commonly occurs in gingiva. It is rarely found in other locations such as the lips, tongue, palate and buccal mucosa. Lesions affecting the upper lip are even rarer and very few cases have been reported in the literature. Read More

Malays J Pathol 2019 Aug;41(2):229-232

Manipal Academy of Higher Education, Manipal College of Dental Sciences, Departments of Oral and Maxillofacial Pathology, Manipal - 576 104, India.

Introduction: Palisaded encapsulated neuroma (PEN) is a benign lesion of Schwann cells and its occurrence in the oral mucosa especially the tongue is very rare.

Case Report: This article describes a case of a 41-year-old male, a chronic smoker with an actively bleeding, ulcerated, solitary, firm lesion on the lateral border of the tongue which had bled thrice before. A differential diagnosis of pyogenic granuloma, haemangioma, fibroma, nerve sheath tumour, salivary gland tumour and malignancy was made and surgically excised. Read More

J Oral Pathol Med 2019 Nov 4;48(10):906-910. Epub 2019 Aug 4.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Background: Pyogenic granuloma (PG) is a benign nodular lesion with a prominent vascular component which may affect different sites. Recently, BRAF, KRAS, HRAS, NRAS, GNA11, and GNA14 mutations were reported on PGs of the skin. The present study assessed the role of the MAPK/ERK pathway in oral PG pathogenesis. Read More

J Coll Physicians Surg Pak 2019 Jul;29(7):680-682

Department of General Medicine, Suyash Multispeciality Hospital, Nashik, Maharashtra 422403, India.

Hemangioendothelioma is a rare, locally aggressive vascular tumor, originating from soft tissue, bone, skin, and organs such as liver or lung and exceptionally the oral cavity. It is usually benign but can show variable grades of malignancy. Most of the cases of oral epithelioid hemangioendotheliomas are asymptomatic, and diagnosis is hampered by the fact that the histological features somewhat overlap with hemangioma and angiosarcoma, with epithelioid cells, intracytoplasmic vacuoles, low mitotic activity, and rarely necrosis. Read More

Natl J Maxillofac Surg 2019 Jan-Jun;10(1):3-7

Department of Pharmacy School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.

Oral pyogenic granuloma or granuloma pyogenicum is a conspicuous lesion. The word pyogenic granuloma is a misterm since the situation is not related with pus and histologically does not exemplify a granuloma. An oral pyogenic granuloma is obvious to involve the gingiva generally. Read More

J Pharm Bioallied Sci 2019 May;11(Suppl 2):S491-S494

Department of pedodontics, Karpaga Vinayaga Institute of Dental Sciences, Kanchipuram, Tamil Nadu, India.

Pyogenic granuloma is a type of inflammatory hyperplasia. The term "inflammatory hyperplasia" is used to describe nodular growths of oral mucosa that histologically contain inflamed fibrous and granulation tissues. It is nonneoplastic. Read More

J Stomatol Oral Maxillofac Surg 2020 Jun 1;121(3):305-307. Epub 2019 Jun 1.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, China; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, China; Department of Periodontics, West China Hospital of Stomatology, Sichuan University, China. Electronic address:

Pyogenic granuloma is a benign growth characterized by active vascular proliferation and is prone to occurring during pregnancy. Given the complicated conditions of this special group of patients, it is controversial to perform removal therapy before delivery. Here, two giant pregnancy pyogenic granulomas of a patient at 34 weeks gestation were safely, completely and minimally invasively removed by water-cooled Nd: YAG laser without anesthetic agents, suturing or antibiotics. Read More

Afr Health Sci 2019 Mar;19(1):1687-1694

Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, University of the Western Cape and Tygerberg Hospital, Cape Town South Africa.

Background: Reactive localized hyperplastic lesions of the oral cavity (RHLs) are relatively common peripheral lesions which present as a range of clinically similar lesions at dental centers. Diagnosis can be challenging if dentists are unfamiliar with their clinicopathological across various populations.

Objective: This study reviews the pattern of distribution of RHLs of the oral mucosa in a hospital- the Obafemi Awolowo University Teaching Hospital Complex (OAUTHC), Ile-Ife. Read More

BMJ Case Rep 2019 May 28;12(5). Epub 2019 May 28.

Ear, Nose and Throat Department, Northwick Park Hospital, Harrow, UK.

Pyogenic granuloma gravidarum is a benign fibrovascular proliferative lesion usually involving the oral gingivae in pregnant patients. While it also occurs, although less frequently, on other oral sites such as lips, tongue and palate, it is relatively unusual to find it in the nasal cavity. Furthermore, lesions normally involute spontaneously after childbirth. Read More

J Clin Aesthet Dermatol 2019 Apr 1;12(4):32-36. Epub 2019 Apr 1.

Drs. Benedetto, Ettefagh, and Nami are with the Western University of Health Sciences in Pomona, California.

The development of periungual pyogenic granulomas while taking the oral acne drug isotretinoin is a known yet uncommon and potentially severe side effect of the oral vitamin A derivative. Previous reports have detailed the development of pyogenic granulomas most commonly arising at sites of previous acne lesions as well as both subungual and periungual locations, with associated paronychia, bleeding, and discomfort. This is thought to arise as a result of the nail bed's fragility and propensity toward spicule formation brought on by the proliferative action of isotretinoin. Read More

Oral Dis 2019 Jun;25 Suppl 1:193-203

Oral Medicine, Eastman Dental Hospital, London, UK.

Objective: To detail a scoping review on the global and regional relative frequencies of oral mucosal disorders in the children based on both clinical studies and those reported from biopsy records.

Materials And Methods: A literature search was completed from 1 January 1990 to 31 December 2018 using PubMed and EMBASE.

Results: Twenty clinical studies (sample size: 85,976) and 34 studies from biopsy services (40,522 biopsies) were included. Read More

Acta Dermatovenerol Croat 2019 Mar;27(1):40-41

Francisco Gil, MD, Departamento de Dermatologia, Hospital de Santarém EPE, Santarém , Portugal;

Dear Editor, Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, locally proliferating disorder that affects predominantly the head and neck region (1,2). There seems to be a higher incidence in middle-aged Caucasian women (2,3). A 28-year-old female patient with no relevant personal or family medical history and only taking an oral contraceptive, presented to our department with multiple, well delimited, infracentimetric erythematous papules with a smooth surface on the left frontal, temporal, and preauricular regions (Figure 1). Read More

J Prosthet Dent 2019 Sep 23;122(3):181-188. Epub 2019 Apr 23.

Associate Professor, Section of Oral Pathology, University of Connecticut Health Center, Farmington, Conn.

Abnormal peri-implant tissue response in the form of benign reactive lesions, such as peripheral giant cell granuloma and pyogenic granuloma, is a less frequent biologic complication associated with dental implant therapy. However, these lesions can cause gingival pain, swelling, and discomfort, as well as peri-implant bone loss and possible implant failure. Few reports in the dental literature have described these lesions around complete-arch fixed implant-supported prostheses. Read More

Rev Esp Enferm Dig 2019 05;111(5):410-411

Aparato Digestivo, Hospital Universitario La Paz.

Pyogenic granulomas are lobular capillary hemangiomas, usually found on skin and oral mucosa. To date, few cases of pyogenic granuloma of the gastrointestinal tract have been reported, being duodenal involvement extremely rare. We report the case of a patient with a history of long-standing iron deficiency anemia where the endoscopy revealed an oozing redish semipedunculated polypoid lesion in the duodenum with a biopsy specimen consistent with a pyogenic granuloma. Read More

J Stomatol Oral Maxillofac Surg 2020 Jun 11;121(3):312-316. Epub 2019 Apr 11.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, PR China. Electronic address:

Epulis is a benign tumor, rarely involves aggressive alveolar bone resorption. This study reported a rare case of rapid growth of pregnancy epulis with extensive alveolar bone destruction and the management of this case. A 24-year old pregnant woman at 35 weeks and 1 day of gestation presented a large asymptomatic nodular mass with severe teeth loosening at the anterior mandibular region for 4 weeks. Read More

J Paediatr Child Health 2019 Apr;55(4):486-487

Division of Oral and Maxillofacial Surgery, Dublin Dental Univeristy Hospital Trinity College Dublin, Dublin, Republic of Ireland.

Saudi J Ophthalmol 2019 Jan-Mar;33(1):109-111. Epub 2018 Jul 25.

Pediatric Ophthalmology and Strabismus, Ophthalmology Department, King Abdul-Aziz University Hospital, King Saud University, Saudi Arabia.

We present a rare case of infected pyogenic conjunctival granuloma mimicking a conjunctival abscess as complication of strabismus surgery in a Saudi girl with exotropia. Despite administration of local antibiotics following strabismus surgery, a patient presented with localised redness and discharge after three weeks. The patient was afebrile with no signs of pre-septal or orbital cellulitis. Read More

J Dent Sci 2018 Sep 2;13(3):285-288. Epub 2013 May 2.

Department of Oral Pathology, Nihon University School of Dentistry at Matsudo, Chiba, Japan.

Peculiar findings of orofacial actinomycosis mimicking the clinical appearance of a tumor of the upper gingiva are reported. An 83-year-old man with bleeding of the gingiva visited our hospital. The clinical diagnosis was a benign gingival tumor, and the lesion was surgically removed. Read More

Head Neck Pathol 2019 Mar 29;13(1):4-15. Epub 2019 Jan 29.

The Ohio State University, 305 W. 12 Ave, Columbus, OH, 43210, USA.

Erythematous lesions of the oral mucosa are common and can reflect a variety of conditions, ranging from benign reactive or immunologically-mediated disorders to malignant disease. Together with vascular abnormalities, which can vary from reddish to bluish-purple in color, the differential diagnosis for erythematous oral mucosal change is quite diverse. This review focuses on salient clinical features and histopathologic findings of selected conditions which clinically present as red or vascular-like oral mucosal alterations, including oral vascular malformations and neoplasms, pyogenic granuloma, localized juvenile spongiotic gingival hyperplasia, denture stomatitis, benign migratory glossitis (geographic tongue), orofacial granulomatosis, granulomatosis with polyangiitis (Wegener granulomatosis), megaloblastic anemia, and erythroplakia. Read More

Head Neck Pathol 2019 Mar 29;13(1):103-113. Epub 2019 Jan 29.

Academic Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield, S10 2TA, UK.

Lesions of the gingivae are amongst the commonest lesions seen in patients and the vast majority are reactive hyperplasias, related to a number of chronic irritant stimuli. However, there are a number of entities that have a predilection for the gingivae, which are much less common in other parts of the oral cavity. The purpose of this paper is to discuss the clinical and histological differential diagnoses when presented with a lump on the gingivae, including the approach to diagnosis and diagnostic pitfalls. Read More

J Oral Pathol Med 2019 Apr 12;48(4):270-277. Epub 2019 Feb 12.

Brazilian Centre for Evidence-Based Research, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil.

Objective: To assess the prevalence of oral mucosal disorders during pregnancy.

Methods: Observational studies were selected by two reviewers in a two-phase process. Search strategies were applied at CINAHL, LILACS, LIVIVO, PubMed, Scopus, Web of Science, Google Scholar, OpenGrey, and ProQuest. Read More

J Dermatol 2019 Jun 10;46(6):e202-e203. Epub 2019 Jan 10.

National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

In Vivo 2019 Jan-Feb;33(1):251-254

Department of Pathology, Immunology and Laboratory of Medicine, University of Florida College of Medicine, Gainesville, FL, U.S.A.

Pyogenic granuloma (PG) represents a lobular capillary proliferation commonly seen in the skin or oral mucosa. They are rarely reported in the gastrointestinal tract. The mechanism underlying PG pathogenesis is not well understood. Read More

J Am Dent Assoc 2019 02 7;150(2):147-153.e2. Epub 2018 Dec 7.

Background: Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a gingival lesion of unknown cause. The purpose of this study is to present a series of LJSGH cases and compare the findings with the literature.

Methods: After obtaining institutional review board approval, cases of biopsy-proven LJSGH from 2008 through 2018 were retrieved from the University of Pittsburgh Oral Pathology Biopsy Service archives and reviewed. Read More

J Exp Ther Oncol 2018 Nov;12(4):291-294

MBBS student, Hind Institute of Medical Sciences, Lucknow, U.P, India.

Objective: A telangiectatic granuloma is a localized reactive lesion associated with prolonged irritation to the soft tissues. It may be misdiagnosed as a vascular malformation, hemangiomas, angiosarcomas, etc; as clinical presentation of the lesions resembles each other. Here, we present a case of asymptomatic swelling in the maxilla of a 17-year old female patient. Read More

J Am Acad Dermatol 2019 Jul 14;81(1):43-56. Epub 2018 Nov 14.

Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts; US Department of Veteran Affairs, Boston Health Care System, Boston, Massachusetts. Electronic address:

A diverse spectrum of benign oral mucosal lesions exists, presenting as either isolated oral findings or in association with dermatologic conditions. Oral lesions can closely resemble one another; therefore, it is important for clinicians to be able to recognize their distinctive features, to be able to recognize benign versus malignant disease, and to recognize when obtaining a biopsy specimen is warranted. The first article in this continuing medical education series reviews oral anatomy, the clinical attributes of several benign lesions of the oral cavity, and appropriate management and therapeutic modalities. Read More

Indian J Dent Res 2018 Sep-Oct;29(5):678-682

Department of Periodontology, Government Dental College and Hospital, Mumbai, Maharashtra, India.

The peripheral giant cell granuloma (PGCG) is a benign oral lesion occurring on the gingiva and alveolar ridge. It is the most common oral lesion and occurs at an average age of 30 years. The upsurge in the levels of estrogen and progesterone in pregnancy leads to a plethora of changes in various parts of human body, including the oral cavity. Read More

Case Rep Dent 2018 14;2018:5180385. Epub 2018 Oct 14.

School of Dentistry, University Center of Patos de Minas (UNIPAM), Patos de Minas, MG, Brazil.

Oral surgery to remove pyogenic granuloma in a high-risk patient is reported. A 47-year-old man with gastroesophageal reflux disease, diabetes mellitus II, dyslipidemia, and chronic coronary insufficiency (myocardial infarction within 2 years) with episodes of unstable angina was submitted to an excisional biopsy of hemorrhagic lesion in the lingual right mandibular gingiva. During dental treatment, the arterial blood pressure, oxygen saturation, heart rate, and electrocardiogram were monitored. Read More

Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39

Institut Universitaire du Cancer Toulouse - Oncopole, 1 avenue Irène Joliot-Curie, 31059, TOULOUSE Cedex 9, France.

Targeted therapies and immunotherapies are associated with a wide range of dermatologic adverse events (dAEs) resulting from common signaling pathways involved in malignant behavior and normal homeostatic functions of the epidermis and dermis. Dermatologic toxicities include damage to the skin, oral mucosa, hair, and nails. Acneiform rash is the most common dAE, observed in 25-85% of patients treated by epidermal growth factor receptor and mitogen-activated protein kinase kinase inhibitors. Read More