4,082 results match your criteria Oral Oncology[Journal]


Racial and socioeconomic disparities associated with 90-day mortality among patients with head and neck cancer in the United States.

Oral Oncol 2019 Feb 29;89:95-101. Epub 2018 Dec 29.

Saint Louis University School of Medicine, Department of Otolaryngology-Head and Neck Surgery, Saint Louis, United States; Saint Louis University Cancer Center, Saint Louis, United States. Electronic address:

Objectives: To quantify head and neck cancer (HNC) mortality rates and identify racial and socioeconomic factors associated with 90-day mortality.

Methods: The National Cancer Database (2004-2014) was queried for eligible HNC cases (n = 260,011) among adults treated with curative intent. Outcome of interest was any-cause 90-day mortality. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.023DOI Listing
February 2019

Long-term oncological and functional outcomes of induction chemotherapy followed by (chemo)radiotherapy vs definitive chemoradiotherapy vs surgery-based therapy in locally advanced stage III/IV hypopharyngeal cancer: Multicenter review of 266 cases.

Oral Oncol 2019 Feb 27;89:84-94. Epub 2018 Dec 27.

Department of Otorhinolaryngology-Head and Neck Surgery, Ilsong Memorial Institute of Head and Neck Cancer, Hallym University, College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: The aim of this study was to evaluate the treatment outcomes for stage III/IV locally advanced hypopharyngeal squamous cell carcinoma (SCC), comparing induction chemotherapy followed by (chemo)radiotherapy (ICT), definitive chemoradiotherapy (CRT) and surgery-based therapy (SRT).

Subjects And Methods: Two hundred sixty-six patients with stage III/IV locally advanced hypopharyngeal squamous cell carcinoma (SCC) who underwent ICT (n = 74), CRT (n = 53) or SRT (n = 139) from 1997 through 2014 at the Seoul National University Hospital (n = 127) and the Hallym University Medical Center (n = 139) were enrolled in the study. All surgical procedures in the SRT group were performed by a single surgeon to eliminate surgeon bias. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.015DOI Listing
February 2019
3.607 Impact Factor

Refining the tumor-node-metastasis staging system for individualized treatment of differentiated thyroid carcinoma.

Oral Oncol 2019 Feb 14;89:8-13. Epub 2018 Dec 14.

Division of Endocrinology & Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

Background: Patients with differentiated thyroid carcinoma (DTC) are staged according to the single age cut point in addition to anatomic extent. A novel staging system is needed to properly show the character and prognosis of DTC by considering age as a continuous variable. We aimed to refine stage and prognostic groups of the eighth edition tumor-node-metastasis (TNM-8) staging system for DTC and to suggest a possible revision. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.014DOI Listing
February 2019
3.607 Impact Factor

Selectively sparing the submandibular gland when level Ib lymph nodes are included in the radiation target volume: An initial safety analysis of a novel planning objective.

Oral Oncol 2019 Feb 26;89:79-83. Epub 2018 Dec 26.

Cleveland Clinic, Department of Radiation Oncology, Cleveland, OH, United States.

Background: Submandibular gland (SMG) metastases are extremely rare in head and neck cancer, even in the presence of level Ib lymph node (LN) involvement. In recent years, we have contoured the SMG and specifically attempted to limit its dose exposure even in patients in whom the level Ib LN station is targeted. This study reports our preliminary feasibility and safety experience with selective submandibular gland sparing. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.021DOI Listing
February 2019

Predictors of cisplatin-induced ototoxicity and survival in chemoradiation treated head and neck cancer patients.

Oral Oncol 2019 Feb 21;89:72-78. Epub 2018 Dec 21.

Department of Medicine, Western University, 1151 Richmond St., London, ON N6A3K7, Canada; Department of Physiology and Pharmacology, Medical Sciences Building, UWO, London, ON N6A 5C1, Canada; Department of Oncology, Division of Experimental Oncology, London Health Sciences Centre, Western University, 800 Commissioners Rd. E., London, ON N6A5W9, Canada. Electronic address:

Objectives: Cisplatin-induced ototoxicity is a common permanent consequence of curative chemoradiation for locally advanced head and neck squamous cell carcinoma (HNSCC). Predictors of ototoxicity in HNSCC were examined.

Materials And Methods: In this prospective, observational cohort study, 206 adult HNSCC patients underwent audiometric testing at baseline, during and after treatment with cisplatin-based chemoradiation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375183046
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http://dx.doi.org/10.1016/j.oraloncology.2018.12.010DOI Listing
February 2019
5 Reads
3.607 Impact Factor

Five-year outcomes of sparing level IB in node-positive, human papillomavirus-associated oropharyngeal carcinoma: A safety and efficacy analysis.

Oral Oncol 2019 Feb 21;89:66-71. Epub 2018 Dec 21.

Department of Radiation Oncology, Cleveland Clinic, Taussig Cancer Center, 10201 Carnegie Ave, CA Building, Cleveland, OH 44195, USA. Electronic address:

Introduction: The conformality of modern intensity modulated radiation therapy (IMRT) allows avoidance of the submandibular glands (SMG) in select patients, potentially improving late xerostomia. This study explores the safety and efficacy of this approach in select oropharyngeal carcinoma (OPC) patients.

Methods: Patients with T1-2N+ human papillomavirus (HPV)-associated OPC treated with definitive IMRT at one institution from 2009 to 2014 were identified. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.020DOI Listing
February 2019
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Cost-effectiveness analysis of the oral cancer screening program in Taiwan.

Oral Oncol 2019 Feb 19;89:59-65. Epub 2018 Dec 19.

Department of Public Health, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Departments of Internal Medicine and Environmental and Occupational Medicine, National Cheng Kung University Hospital, Tainan, Taiwan. Electronic address:

Objectives: We assess the incremental cost-effectiveness ratio (ICER) of the oral cancer (OC) screening program in Taiwan.

Materials And Methods: We interlinked the Cancer Registry, Mortality Registry, National Vital Statistics, reimbursement database of National Health Insurance, and the National Oral Cancer Screening database of Taiwan. A total of 40,092 pathologically verified OC patients were identified and followed during 2002-2014. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375183046
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http://dx.doi.org/10.1016/j.oraloncology.2018.12.011DOI Listing
February 2019
2 Reads

The relative distribution of oral cancer in the United States by subsite.

Oral Oncol 2019 Feb 18;89:56-58. Epub 2018 Dec 18.

Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.017DOI Listing
February 2019

Impact of gender on the association between marital status and head and neck cancer outcomes.

Oral Oncol 2019 Feb 18;89:48-55. Epub 2018 Dec 18.

Saint Louis University School of Medicine, Department of Otolaryngology-Head and Neck Surgery, St. Louis, USA; Saint Louis University Cancer Center, St. Louis, USA. Electronic address:

Objectives: To determine whether the impact of marital status on head and neck cancer (HNC) outcomes vary by gender.

Methods: The Surveillance, Epidemiology, and End Results 18 database from 2007 to 2014 was queried for eligible cases of HNC (n = 71,799). An interaction term (gender*marital status) was tested for each outcome of interest (cancer-specific survival, stage of presentation, adequate treatment), and when significant (p < 0. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.009DOI Listing
February 2019

Long-term survival and late toxicities of elderly nasopharyngeal carcinoma (NPC) patients treated by high-total- and fractionated-dose simultaneous modulated accelerated radiotherapy with or without chemotherapy.

Oral Oncol 2019 Feb 18;89:40-47. Epub 2018 Dec 18.

Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou 510060, China. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.008DOI Listing
February 2019

Expression of immune-regulatory molecules in circulating tumor cells derived from patients with head and neck squamous cell carcinoma.

Oral Oncol 2019 Feb 17;89:34-39. Epub 2018 Dec 17.

Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.

Objectives: Circulating tumor cells (CTCs) are cells that have shed from tumor tissue into the bloodstream, and the detection and characterization of CTCs in head and neck squamous cell carcinoma (HNSCC) still remain a challenge.

Materials And Methods: CTCs were isolated from 30 patients with HNSCC with recurrent and/or distant metastasis, via the depletion of CD45-positive cells with magnetic beads and the expression of multiple epithelial markers (CK19, EpCAM, EGFR, and c-Met) was analyzed by RT-qPCR with a low concentration of RNA from the CTC population. We next investigated the expression of the immune-regulatory molecules, PD-L1, PD-L2, and CD47, in CTC-positive patients and the PD-L1 expression in CTCs was compared with that in tumor tissues. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.002DOI Listing
February 2019
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The microbiome and oral cancer: More questions than answers.

Oral Oncol 2019 Feb 17;89:30-33. Epub 2018 Dec 17.

Division of Oral Biosciences, School of Dental Science, Trinity College Dublin, Dublin Dental University Hospital, Dublin, Ireland. Electronic address:

Recent advances in DNA sequencing technology have facilitated rapid advances in the analysis of the human microbiome and its role in human disease. Several studies have now shown that OSCC and some oral premalignant conditions are associated with alterations in the oral microbiome. These studies raise questions regarding the role of the oral microbiome in the progression of oral malignancies and whether microbiome change is a significant risk factor in the development of oral cancer. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.003DOI Listing
February 2019

The prognostic impact of pathologic lymph nodes in HPV-positive oropharyngeal cancers.

Oral Oncol 2019 Feb 15;89:23-29. Epub 2018 Dec 15.

The Bloomberg-Kimmel Institute for Cancer Immunotherapy, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Johns Hopkins Division of Biostatistics and Bioinformatics, Johns Hopkins University School of Medicine, 550 North Broadway, Baltimore, MD 21287, USA.

Purpose: Recent pathologic staging of HPV-positive oropharyngeal squamous cell carcinomas (OPSCC) is solely dependent on number of pathologic nodes. Using a large dataset, we aimed to understand how increase in pathologic lymph nodes (LN) associated with overall survival.

Materials And Methods: National Cancer Database was queried for HPV-positive OPSCC patients undergoing primary surgery with LN dissection between 2010 and 2013. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.005DOI Listing
February 2019
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Clinical outcomes and management of facial nerve in patients with parotid gland cancer and pretreatment facial weakness.

Oral Oncol 2019 Feb 12;89:144-149. Epub 2019 Jan 12.

Department of Otorhinolaryngology-Head and Neck Surgery, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Objectives: In parotid gland cancer (PGC), it is not clear whether facial weakness always reflects tumor invasion of the facial nerve (FN) requiring nerve resection. The aims of this study were to evaluate oncological and functional outcomes in patients with PGC and pre-treatment facial weakness, and to analyze local tumor invasion of the FN.

Materials And Methods: The clinical outcomes of patients (n = 45) with PGC and pretreatment facial weakness were retrospectively analyzed. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.003DOI Listing
February 2019

Obesity and genes related to lipid metabolism predict poor survival in oral squamous cell carcinoma.

Oral Oncol 2019 Feb 14;89:14-22. Epub 2018 Dec 14.

Department of Oral Medicine, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China. Electronic address:

Objectives: Obesity is an important risk factor for several malignancies, but its effect on oral squamous cell carcinoma (OSCC) prognosis is controversial. We aimed to disclose the association between obesity and the OSCC outcome, and explore the potential of some lipid metabolism-related genes as biomarkers for prognostic prediction.

Materials And Methods: A total of 576 patients diagnosed as T1/2N0M0 OSCC without prediagnosis weight loss was included in this retrospective study. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.006DOI Listing
February 2019

Lymph node ratio as prognostic variable in oral squamous cell carcinomas: Systematic review and meta-analysis.

Oral Oncol 2019 Feb 8;89:133-143. Epub 2019 Jan 8.

Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. Electronic address:

Lymph node ratio (LNR) has been shown to be an independent prognostic factor for oral squamous cell carcinoma (OSCC) in various centre-based studies recently. A range of cut-off values have been suggested. A meta-analysis was performed to evaluate the prognostic effects of LNR and to investigate the cut-off value. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.032DOI Listing
February 2019
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Long-term speech and swallowing function after primary resection and sentinel node biopsy for early oral squamous cell carcinoma.

Oral Oncol 2019 Feb 9;89:127-132. Epub 2019 Jan 9.

Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital St. Gallen, Switzerland.

Objectives: Analysis of long-term speech and swallowing function and subjective quality of life (QOL) after primary resection and sentinel node biopsy (SNB) in patients with early stage (cT1/T2) oral squamous cell carcinomas (OSCC).

Material And Methods: Eighty-one consecutive patients treated primarily by transoral resection without flap reconstruction and SNB for a cT1/T2 OSCC were included. Completion neck dissection (CND) was indicated in case of occult disease in the sentinel nodes. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.027DOI Listing
February 2019
2 Reads

Immunologic mediators of outcome for irradiated oropharyngeal carcinoma based on human papillomavirus status.

Oral Oncol 2019 Feb 4;89:121-126. Epub 2019 Jan 4.

Department of Radiation Oncology, Los Angeles, CA 90095, USA; Department of Radiation Oncology, University of California, Irvine, School of Medicine, 101 The City Drive, Building 23, Orange, CA 92868, USA. Electronic address:

Purpose: To investigate the prognostic value of pre-treatment immune parameters including white blood cell count (WBC) and circulating lymphocyte count (CLC) among patients with oropharyngeal carcinoma treated by radiation therapy.

Methods And Materials: A total of 136 consecutive patients were treated by radiation therapy for locally advanced (stage III/IV) squamous cell carcinoma of the oropharynx with known human papillomavirus (HPV) status. Medical records were reviewed to identify patients with documented pre-treatment laboratory bloodwork. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.030DOI Listing
February 2019
1 Read

Travel time to provider is associated with advanced stage at diagnosis among low income head and neck squamous cell carcinoma patients in North Carolina.

Oral Oncol 2019 Feb 2;89:115-120. Epub 2019 Jan 2.

Lineberger Cancer Center, Chapel Hill, NC, USA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.

Objective: There is considerable variation in the travel required for a patient with head and neck squamous cell carcinoma (HNSCC) to receive a diagnosis. The impact of this travel on the late diagnosis of cancer remains unexamined, even though presenting stage is the strongest predictor of mortality. Our aim is to determine whether travel time affects HNSCC stage at diagnosis independently of other risk factors, and whether this association is affected by socioeconomic status. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369700PMC
February 2019

Finding an oral potentially malignant disorder in screening program is related to early diagnosis of oral cavity cancer - Experience from real world evidence.

Oral Oncol 2019 Feb 31;89:107-114. Epub 2018 Dec 31.

Division of Medical Statistics and Bioinformatics, Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taiwan; School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

Objectives: Our study evaluates the effectiveness of the Taiwan Oral Mucosal Screening (TOMS) program in stage-shift among oral cavity cancer patients, and identifies the related factors with early cancer diagnosis.

Materials And Methods: This retrospective cohort study used the Taiwan Cancer Registry (TCR), TOMS and Taiwan Death Registry (TDR) databases. We identified oral cavity cancer patients (ICD-C-O: C00-C06) from the TCR during 2012-2015. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.007DOI Listing
February 2019

Optimizing the cumulative cisplatin dose during radiotherapy in nasopharyngeal carcinoma: Dose-effect analysis for a large cohort.

Oral Oncol 2019 Feb 31;89:102-106. Epub 2018 Dec 31.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China. Electronic address:

Objectives: Definitive concurrent chemoradiotherapy (CCRT) is the standard treatment for locoregionally advanced nasopharyngeal carcinoma (NPC). The cumulative cisplatin dose (CCD) during radiotherapy is an important prognostic factor; however, the optimal CCD is undetermined.

Materials And Methods: In this retrospective analysis, patients with locoregionally advanced NPC treated with single-agent cisplatin-based CCRT or RT alone from 2009 through 2015 were identified. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.028DOI Listing
February 2019
3.607 Impact Factor

A novel anatomy-based five-points eight-line-segments technique for precision subtotal tongue reconstruction: A pilot study.

Oral Oncol 2019 Feb 13;89:1-7. Epub 2018 Dec 13.

Oral & Maxillofacial-Head & Neck Digital Precision Reconstruction Technology Research Center of Guangdong Province, Guangzhou 510120, China; Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou 510120, China. Electronic address:

Objectives: A no-flap design based on actual tongue anatomy has been reported to achieve precise reconstruction, but large carcinologic tongue defects remain extremely challenging to treat. The aim of this pilot study was to explore an anatomy-based flap design for precision subtotal tongue reconstruction.

Material And Methods: Thirty-five patients were randomly divided into two groups, a "five-points eight-line-segments" (FIPELS) technique flap design group (18 patients) and a conventional surgery group (17 patients), to undergo subtotal tongue reconstruction. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.004DOI Listing
February 2019

Impressive oral lichen planus progression to invasive squamous cell carcinoma in a three months lapse.

Oral Oncol 2019 Jan 28. Epub 2019 Jan 28.

Dermatology Clinic - Department of Medical Sciences and Public Health, University of Cagliari, Via Ospedale 54, 09124 Cagliari, Italy.

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.029DOI Listing
January 2019

Assessing the role of cell fusion in cancer metastasis.

Oral Oncol 2019 Jan 21. Epub 2019 Jan 21.

Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, India.

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.006DOI Listing
January 2019
3.607 Impact Factor

RE: Impact of radical treatments on survival in locally advanced T4a and T4b buccal mucosa cancers: Selected surgically treated T4b cancers have similar control rates as T4a.

Oral Oncol 2019 Jan 21. Epub 2019 Jan 21.

Head and Neck Oncology, Health Care Global Enterprises Ltd, Bangalore, India.

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.008DOI Listing
January 2019
3.607 Impact Factor

How far can regulating TRIM16 help reduce malignant transformation of OPMD's to OSCC?

Authors:
Samapika Routray

Oral Oncol 2019 Jan 18. Epub 2019 Jan 18.

Department of Dentistry, All India Institute of Medical Sciences, Bhubaneswar, Odisha 751019, India. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.007DOI Listing
January 2019

Beta human papillomaviruses in middle ear squamous cell carcinoma.

Oral Oncol 2019 Jan 18. Epub 2019 Jan 18.

HPV Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy; UOSD Tumor Immunology and Immunotherapy, IRCCS Regina Elena National Cancer Institute, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.004DOI Listing
January 2019

Dramatic response under combination of immune-oncology in head & neck cancer included in the Condor study: A case report.

Oral Oncol 2019 Feb 11;89:150-152. Epub 2019 Jan 11.

Department of Medical Oncology, Hôpital Saint-André, Bordeaux University Hospital-CHU Bordeaux, France; University of Bordeaux, Bordeaux, France; ImmunoConcEpt, CNRS UMR 5164, Bordeaux University, Bordeaux 33076, France.

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.002DOI Listing
February 2019

Malignant extrapleural solitary fibrous tumor arising in the sublingual gland: A case report and review of literature.

Oral Oncol 2019 Jan 9. Epub 2019 Jan 9.

Pathology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.

Solitary fibrous tumor is an uncommon neoplasm with unpredictable clinical behavior. Malignant solitary fibrous tumor is a rare morphological variant with more aggressive behavior and higher rates of local recurrences and distant metastasis, exceeding rare in oral cavity; our case occurred in the floor of the mouth in the sublingual gland. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.013DOI Listing
January 2019

Immune microenvironment and evasion mechanisms in adenoid cystic carcinomas of salivary glands.

Oral Oncol 2019 Jan 23;88:95-101. Epub 2018 Nov 23.

Department of Stomatology (Oral Pathology), School of Dentistry, Universidade Federal de Goiás, Goiânia, GO, Brazil. Electronic address:

Objectives: The objective of the present study was to investigate the expression of immune checkpoints (PD-L1, PD-L2, PD-1 and CTLA-4), immune inhibitory molecule HLA-G, markers of tumor-infiltrating lymphocytes (TIL) and dendritic cells (DC), as well as its association with clinicopathological features of adenoid cystic carcinomas (ACC) of the salivary glands.

Materials And Methods: Thirty-six samples from patients with ACC were analyzed immunohistochemically for the expression of PD-L1, PD-L2, PD-1, CTLA-4, HLA-G, CD8, GrB, CD1a and CD83. Positivity of HLA-G, PD-L1 and PD-L2 expression was defined by cut-offs values. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375183044
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http://dx.doi.org/10.1016/j.oraloncology.2018.11.028DOI Listing
January 2019
6 Reads

Oral cancer prevention worldwide: Challenges and perspectives.

Oral Oncol 2019 Jan 22;88:91-94. Epub 2018 Nov 22.

Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de recherche en cancérologie de Lyon, Lyon 69008, France; Department of Medicine, Centre Léon Bérard, Lyon, France. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.008DOI Listing
January 2019

High-risk pathological features at the time of salvage surgery predict poor survival after definitive therapy in patients with head and neck squamous cell carcinoma.

Oral Oncol 2019 Jan 16;88:9-15. Epub 2018 Nov 16.

Department of Internal Medicine, Division of Hematology/Oncology, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address:

Objectives: Salvage surgical resection is the preferred treatment for head and neck squamous cell carcinoma (HNSCC) patients who develop locally recurrent disease after failing primary therapy. However, salvage surgical resection is not always feasible, and survival outcomes for those that do undergo salvage remain poor. It is well known that patients with adverse pathological features (extracapsular extension (ECE) of lymph nodes (LN), positive margins, perineural invasion (PNI), lymphovascular invasion (LVI), and multiple LN metastases) at the time of primary surgical resection are likely to have relatively poor outcomes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375183042
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http://dx.doi.org/10.1016/j.oraloncology.2018.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327963PMC
January 2019
2 Reads

Prognostic factors and selection criteria in the retreatment of head and neck cancers.

Oral Oncol 2019 Jan 22;88:85-90. Epub 2018 Nov 22.

Department of Radiation Oncology, University of Louisville School of Medicine, 529 S Jackson St, Ste 400, Louisville, KY 40202, USA; James Graham Brown Cancer Center, 529 S Jackson St, Louisville, KY 40202, USA. Electronic address:

Objectives: To determine predictors of treatment selection, outcome, and survival, we examined a cohort of previously irradiated head and neck squamous cell carcinoma (HNSCC) patients.

Materials And Methods: We retrospectively analyzed 100 patients at our institution who were treated for recurrent or second primary (RSP) HNSCC, focusing on subgroups receiving reirradiation (ReRT) alone and those undergoing surgical salvage (SS) with or without post-operative reirradiation therapy (POReRT). Logistic regression modeling was performed to identify factors predictive of retreatment modality. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.024DOI Listing
January 2019
1 Read

HPV related head and neck squamous cell carcinoma: New evidences for an emerging spontaneous animal model.

Oral Oncol 2019 Jan 22;88:84. Epub 2018 Nov 22.

Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via Delpino 1, 80137 Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.027DOI Listing
January 2019

Functional imaging early during (chemo)radiotherapy for response prediction in head and neck squamous cell carcinoma; a systematic review.

Oral Oncol 2019 Jan 22;88:75-83. Epub 2018 Nov 22.

Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands.

This systematic review gives an extensive overview of the current state of functional imaging during (chemo)radiotherapy to predict locoregional control (LRC) and overall survival (OS) for head and neck squamous cell carcinoma. MEDLINE and EMBASE were searched for literature until April 2018 assessing the predictive performance of functional imaging (computed tomography perfusion (CTp), MRI and positron-emission tomography (PET)) within 4 weeks after (chemo)radiotherapy initiation. Fifty-two studies (CTp: n = 4, MRI: n = 19, PET: n = 26, MRI/PET: n = 3) were included involving 1623 patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375183041
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http://dx.doi.org/10.1016/j.oraloncology.2018.11.005DOI Listing
January 2019
1 Read

Intensity modulated proton therapy (IMPT) - The future of IMRT for head and neck cancer.

Oral Oncol 2019 Jan 21;88:66-74. Epub 2018 Nov 21.

Department of Radiation Oncology, Gustave Roussy, Villejuif, France. Electronic address:

Radiation therapy plays an integral role in the management of head and neck cancers (HNCs). While most HNC patients have historically been treated with photon-based radiation techniques such as intensity modulated radiation therapy (IMRT), there is a growing awareness of the potential clinical benefits of proton therapy over IMRT in the definitive, postoperative and reirradiation settings given the unique physical properties of protons. Intensity modulated proton therapy (IMPT), also known as "pencil beam proton therapy," is a sophisticated mode of proton therapy that is analogous to IMRT and an active area of investigation in cancer care. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375183042
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http://dx.doi.org/10.1016/j.oraloncology.2018.11.015DOI Listing
January 2019
3 Reads
3.607 Impact Factor

Rapid, non-invasive fluorescence margin assessment: Optical specimen mapping in oral squamous cell carcinoma.

Oral Oncol 2019 Jan 21;88:58-65. Epub 2018 Nov 21.

Department of Otolaryngology, Stanford University School of Medicine, 900 Blake Wilbur Drive, Stanford, CA 94305, United States. Electronic address:

Objective: Surgical resection remains the primary treatment for the majority of solid tumors. Despite efforts to obtain wide margins, close or positive surgical margins (<5 mm) are found in 15-30% of head and neck cancer patients. Obtaining negative margins requires immediate, intraoperative feedback of margin status. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.012DOI Listing
January 2019

The efficacy of neutron radiation therapy in treating salivary gland malignancies.

Oral Oncol 2019 Jan 21;88:51-57. Epub 2018 Nov 21.

Department of Oral and Maxillofacial Surgery, Harborview Medical Center, University of Washington, USA. Electronic address:

Objectives: Radiation therapy is commonly used to treat head and neck malignancies. While there is abundant research regarding photon radiation therapy, literature on neutron radiotherapy (NRT) and oral complications is limited. This study aims to determine: (1) the 6-year and 10-year locoregional control and survival rates, (2) factors associated with locoregional control and survival and (3) the frequency of oral complications in patients undergoing NRT for salivary gland malignancies. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.006DOI Listing
January 2019

Special section on intensity-modulated radiation therapy for head and neck cancer (IMRT).

Oral Oncol 2019 Jan 20;88:49-50. Epub 2018 Nov 20.

Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China.

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.018DOI Listing
January 2019
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The impact of treatment package time on survival in surgically managed head and neck cancer in the United States.

Oral Oncol 2019 Jan 20;88:39-48. Epub 2018 Nov 20.

Department of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, UCLA Medical Center, Los Angeles, CA, USA; UCLA Head and Neck Cancer Program, UCLA Medical Center, Los Angeles, CA, USA.

Objectives: Delays in the initiation of postoperative radiation have been associated with worse outcomes; however, the effect of the overall treatment package time (interval from surgery through the completion of radiation) remains undefined. The purpose of this study was to determine the impact of package time on survival and to evaluate this effect among different subgroups of head and neck cancer patients.

Patients And Methods: In this observational cohort study, the National Cancer Database was used to identify 35,167 patients with resected nonmetastatic head and neck cancer who underwent adjuvant radiation from 2004 to 2014. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.021DOI Listing
January 2019

Macrophages in the microenvironment of head and neck cancer: potential targets for cancer therapy.

Oral Oncol 2019 Jan 20;88:29-38. Epub 2018 Nov 20.

Medical Oncology Department, Hôpitaux Universitaires Paris Nord Val de Seine (HUPVNS) & Université Paris 7, Paris, France. Electronic address:

The microenvironment of solid tumors has become a promising target for future therapies modulating immune cells. Patients with advanced head and neck cancer, which still portends a poor outcome, are particularly in need of innovative approaches. In oral squamous cell carcinoma, high density of tumor-associated macrophages (TAMs) appears consistently associated with poor prognosis, whereas data are currently limited for other head and neck sites. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.10.040DOI Listing
January 2019

8 "S" in oral cancer.

Oral Oncol 2019 Jan 16;88:27-28. Epub 2018 Nov 16.

Health Care and Global Enterprises Ltd, Bangalore 560027, India. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.016DOI Listing
January 2019
3.607 Impact Factor

Radiation therapy quality assurance in head and neck radiotherapy - Moving forward.

Oral Oncol 2019 Jan 10;88:180-185. Epub 2018 Dec 10.

GenesisCare Radiation Oncology, Division Radiation Oncology, St. Vincent's Hospital, Melbourne, Australia.

Head and Neck Cancer (HNC) radiation oncologists (ROs) enjoy the immense pleasure of curing patients, working within a large multidisciplinary team to effectively deliver curative intent treatment whilst also aiming to minimise late treatment toxicity. Secondary analyses of large-scale HNC clinical trials have shown the critical impact of the quality of radiotherapy plans, where protocol non-compliant plans have yielded inferior survival rates approximating 20%. The peer review process in routine day-to-day HNC practice shows that even in major academic centers a significant proportion of RT plans may require changes to the radiotherapy planning volume. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.014DOI Listing
January 2019

Comparative effectiveness of primary radiotherapy versus surgery in elderly patients with locally advanced oropharyngeal squamous cell carcinoma.

Oral Oncol 2019 Jan 16;88:18-26. Epub 2018 Nov 16.

Department of Clinical Sciences, UT Southwestern Medical Center, Dallas, TX, USA.

Objectives: To determine the comparative effectiveness of primary radiotherapy (RT) and primary surgery (PS) for locally advanced oropharyngeal squamous cell carcinoma (OPSCC).

Materials And Methods: Eligible individuals were patients in the SEER-Medicare registry diagnosed with locally advanced OPSCC between 2000 and 2011. Patients were categorized as receiving either primary RT ± chemotherapy, or PS ± adjuvant RT or chemoradiotherapy (CRT). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375183041
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http://dx.doi.org/10.1016/j.oraloncology.2018.11.004DOI Listing
January 2019
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From reactive to proactive tube feeding during chemoradiotherapy for head and neck cancer: A clinical prediction model-based approach.

Oral Oncol 2019 Jan 7;88:172-179. Epub 2018 Dec 7.

Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Oral and Maxillofacial Surgery, Academic Medical Center, Amsterdam, the Netherlands.

Objectives: Feeding tubes are placed unnecessarily in a proportion of head and neck cancer (HNC) patients treated with chemoradiotherapy (CRT) when prophylactic tube placement protocols are used. This may have a negative impact on the risk of long-term dysphagia. Reactive tube placement protocols, on the other hand, might result in weight loss and treatment interruption. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.031DOI Listing
January 2019

Going beyond extracapsular dissection in cystadenolymphomas of the parotid gland.

Oral Oncol 2019 Jan 7;88:168-171. Epub 2018 Dec 7.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Erlangen-Nuremberg, Erlangen, Germany.

Background: The aim of this study was to evaluate the potential for reducing surgical invasiveness in parotid cystadenolymphomas by means of capsular dissection based on the experience made in our department and on various aspects of these lesions gained from the relevant literature.

Methods: All patients treated for cystadenolymphomas with extracapsular or capsular dissection at a tertiary referral center between 2000 and 2017 were examined retrospectively. A literature review of various aspects and of different treatment strategies for this lesion was also performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375183045
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http://dx.doi.org/10.1016/j.oraloncology.2018.12.001DOI Listing
January 2019
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Down-regulation and nuclear localization of survivin by sodium butyrate induces caspase-dependent apoptosis in human oral mucoepidermoid carcinoma.

Oral Oncol 2019 Jan 5;88:160-167. Epub 2018 Dec 5.

Department of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 03080, Republic of Korea. Electronic address:

Objective: Sodium butyrate (NaBu) is a histone deacetylase inhibitor that possesses an apoptotic ability. However, the molecular mechanism by which NaBu induces apoptosis in human oral mucoepidermoid carcinoma (MEC), a type of salivary gland tumor, remains unclear.

Materials And Methods: The anticancer effects of NaBu and its related molecular mechanisms were determined by trypan blue exclusion assay, 4'-6-diamidino-2-phenylindole staining, live/dead assay, human apoptosis array, RT-PCR, western blotting, immunocytochemistry, preparation of nuclear fractions, and nude mice tumor xenograft. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.032DOI Listing
January 2019
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A myxoma in the temporomandibular joint: Case report and review of the literature.

Oral Oncol 2019 Jan 16;88:16-17. Epub 2018 Nov 16.

Pathology Department, Infanta Cristina Hospital, Badajoz, Spain.

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.017DOI Listing
January 2019

Utility of a repeat PET/CT scan in HPV-associated Oropharyngeal Cancer following incomplete nodal response from (chemo)radiotherapy.

Oral Oncol 2019 Jan 5;88:153-159. Epub 2018 Dec 5.

Department of Cancer Services, Princess Alexandra Hospital, 199 Ipswich Road, Woolloongabba, Queensland, Australia; Faculty of Medicine, University of Queensland, St. Lucia, Australia.

Objectives: To assess the utility of a repeat positron emission tomography/computed tomography (PET/CT) instead of immediate neck dissection (ND) for incomplete nodal response (IR) in Human Papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPC) following chemoradiotherapy/radiotherapy [(chemo)RT].

Materials And Methods: Patients with non-distant metastatic, node positive (N+) disease treated between Jan/2005 to Jan/2016, achieved complete response at the primary with no distant relapse on a 12-week re-staging PET/CT were evaluated. Patients underwent surveillance after complete nodal response (CR). Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.033DOI Listing
January 2019

Evidence for the approach to the diagnostic evaluation of squamous cell carcinoma occult primary tumors of the head and neck.

Oral Oncol 2019 Jan 30;88:145-152. Epub 2018 Nov 30.

Institute of Head and Neck Studies and Education (InHANSE), Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address:

Metastases to the cervical lymph nodes from a occult primary (CUP) of head and neck squamous carcinomas has been increasing in presentation (HNSCC). Modern diagnostic workup, including clinical evaluation, conventional imaging, FDG-PET/CT and panendoscopy/tonsillectomy enables detection of the primary site in over half of all cases, and is associated with significantly improved survival rates. Recent studies have demonstrated the utility of novel molecular pathology and transoral surgical techniques in improving diagnosis and treatment. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.020DOI Listing
January 2019
1 Read