4,133 results match your criteria Oral Oncology[Journal]


Human papillomavirus (HPV) vaccine and HPV-related head and neck cancer: What's next?

Oral Oncol 2019 Apr 4. Epub 2019 Apr 4.

Department of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.

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http://dx.doi.org/10.1016/j.oraloncology.2019.04.001DOI Listing

Transoral tongue base mucosectomy for the identification of the primary site in the work-up of cancers of unknown origin: Systematic review and meta-analysis.

Oral Oncol 2019 Apr 6;91:97-106. Epub 2019 Mar 6.

Department of Otolaryngology, Head and Neck Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; Institute of Head and Neck Studies and Education, University of Birmingham, UK; Institute of Cancer and Genomic Sciences, University of Birmingham, UK. Electronic address:

Background: The use of transoral robotic surgery (TORS) and laser microsurgery (TLM) in the diagnosis and identification of the site of the unknown primary has become increasingly common. This systematic review and meta-analysis aims to assess the use and efficacy of TORS and TLM for this indication.

Method: Systematic review and meta-analysis of studies employing TORS or TLM in diagnosis of the unknown primary tumor site in patients with cervical nodal metastases of squamous cell origin. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.018DOI Listing
April 2019
4 Reads

Human papillomavirus DNA detection, p16, and oral cavity cancer in a U.S. population.

Oral Oncol 2019 Apr 5;91:92-96. Epub 2019 Mar 5.

Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Objectives: The role of HPV in oral cavity cancers was investigated using two markers of viral exposure.

Materials And Methods: HPV DNA and p16 expression were evaluated in tumor tissue from a U.S. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375193007
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http://dx.doi.org/10.1016/j.oraloncology.2019.03.001DOI Listing
April 2019
9 Reads

Surgical salvage of recurrent T3 nasopharyngeal carcinoma: Prognostic significance of clivus, maxillary, temporal and sphenoid bone invasion.

Oral Oncol 2019 Apr 4;91:85-91. Epub 2019 Mar 4.

Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Li Ka Shing Faculty of Medicine, Queen Mary Hospital, China.

Background: To study the efficacy of surgery for recurrent T3 nasopharyngeal carcinoma (NPC) and to determine the prognostic significance of various skull base bone invasion.

Method: Retrospective view of the surgical outcome for recurrent T3 NPC. Kaplan Meier and log rank tests were used to determine the 5-year overall and disease specific survival. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.023DOI Listing

Accuracy of magnetic resonance imaging in evaluating the depth of invasion of tongue cancer. A prospective cohort study.

Oral Oncol 2019 Apr 4;91:79-84. Epub 2019 Mar 4.

Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, PR China. Electronic address:

Objectives: This study compared the consistency of depth of invasion (DOI) measurements by magnetic resonance imaging (MRI) and intraoperative and postoperative pathological sections due to a lack of large sample studies.

Materials And Methods: From April 2015 to December 2017, patients with squamous cell carcinoma of the tongue were included in the study. Different invasion depths were measured by MRI and on intraoperative and postoperative pathological sections. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.021DOI Listing
April 2019
1 Read

Patterns of EBV-positive cervical lymph node involvement in head and neck cancer and implications for the management of nasopharyngeal carcinoma T0 classification.

Oral Oncol 2019 Apr 16;91:7-12. Epub 2019 Feb 16.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People's Republic of China. Electronic address:

Objectives: Epstein-Barr virus (EBV)-positive cervical lymph node (CLN) metastasis of unknown primary origin is classified as nasopharyngeal carcinoma (NPC) T0 by the American Joint Committee on Cancer staging manual (8th edition). We aimed to investigate the possible primary sites and patterns of EBV-positive CLN metastases and to provide implications for the management of NPC T0 classification.

Materials And Methods: We retrospectively reviewed 269 patients with newly diagnosed EBV-positive CLN metastatic disease who underwent EBV detection via EBV-encoded RNA in situ hybridization. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.012DOI Listing
April 2019
2 Reads

PTEN loss is associated with resistance to cetuximab in patients with head and neck squamous cell carcinoma.

Oral Oncol 2019 Apr 4;91:69-78. Epub 2019 Mar 4.

Department of Medicine, Yale University School of Medicine and Yale Cancer Center, United States. Electronic address:

Introduction: Cetuximab, a monoclonal antibody to the epidermal growth factor receptor (EGFR), extends survival in combination with standard therapy in head and neck squamous cell carcinoma (HNSCC). However, as effects are modest, and patients experience side effects, a biomarker to predict resistance and personalize therapy is needed. Activation of signaling pathways downstream from receptor tyrosine kinases predicts resistance to such therapies in other cancers. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.026DOI Listing
April 2019
3 Reads

Diverging incidence trends for larynx and tonsil cancer in low socioeconomic regions of the US.

Oral Oncol 2019 Apr 4;91:65-68. Epub 2019 Mar 4.

Department of Surgical Oncology, Division of Head and Neck Surgery, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA, United States. Electronic address:

Objective: Oropharynx cancer incidence trends in low socioeconomic (SES) regions of the United States (US) have not been well described. Our objective was to describe tonsil cancer incidence trends in low SES regions, and compare observed trends with those for larynx cancer.

Materials And Methods: Age-adjusted incidence rates and trends for tonsil and larynx squamous cell carcinomas (2000-14) from Surveillance, Epidemiology, and End Results (SEER 18) were evaluated using SEER*Stat and Joinpoint 4. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.024DOI Listing

Patient access to voice prostheses and heat and moisture exchangers: Factors influencing physician's prescription and reimbursement in eight European countries.

Oral Oncol 2019 Apr 1;91:56-64. Epub 2019 Mar 1.

Division of Psychosocial Research and Epidemiology, the Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Health Technology and Services Research, University of Twente, Drienerlolaan 5, 7522 NB Enschede, the Netherlands. Electronic address:

Objectives: Patient access to the voice prosthesis and heat and moisture exchanger (HME) is not always guaranteed in Europe. Therefore, the aim of this qualitative study is to evaluate factors influencing physician's prescription and reimbursement of these devices in eight European countries, and to identify barriers of and facilitators to effective patient access.

Materials And Methods: In this mixed methods study, we conducted a survey among stakeholders evaluating prescription (Part 1 of the survey), reimbursement (Part 2), and barriers of and facilitators to effective patient access (Part 3). Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.017DOI Listing

The prognosis of head and neck squamous cell carcinoma related to immunosuppressive tumor microenvironment regulated by IL-6 signaling.

Oral Oncol 2019 Apr 28;91:47-55. Epub 2019 Feb 28.

Chang Gung University College of Medicine, Taiwan; Department of Radiation Oncology, Chang Gung Memorial Hospital at Chiayi, Taiwan. Electronic address:

Evasion of immune surveillance is a significant factor in head and neck squamous cell carcinoma (HNSCC) carcinogenesis. IL-6 signaling is a critical mechanism for the induction of dysfunctional immune responses. In the present study, we examined the role of IL-6 in the prognosis of HNSCC regarding the immunosuppressive tumor microenvironment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375193007
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http://dx.doi.org/10.1016/j.oraloncology.2019.02.027DOI Listing
April 2019
1 Read

Results of a combination treatment with intensity modulated radiotherapy and active raster-scanning carbon ion boost for adenoid cystic carcinoma of the minor salivary glands of the nasopharynx.

Oral Oncol 2019 Apr 27;91:39-46. Epub 2019 Feb 27.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120 Heidelberg, Germany. Electronic address:

Objectives: We aimed to present the first clinical results for adenoid cystic carcinoma (ACC) of the nasopharynx after primary radiotherapy (RT) with the focus on local control (LC) and patterns of recurrence.

Materials And Methods: We retrospectively analyzed 59 patients with ACC of the nasopharynx, who were treated with bimodal radiotherapy (RT) consisting of intensity modulated radiotherapy and carbon ion boost at the Heidelberg Ion-Beam Therapy Center between 2009 and 2018. The patients had predominantly inoperable (n = 42, 72%) or incompletely resected (n = 17, 29%) tumors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375193006
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http://dx.doi.org/10.1016/j.oraloncology.2019.02.019DOI Listing
April 2019
7 Reads

Quality insurance in head and neck cancer multidisciplinary team meetings: A watchful eye on real-life experience.

Oral Oncol 2019 Apr 26;91:35-38. Epub 2019 Feb 26.

Department of Radiotherapy, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France. Electronic address:

Introduction: Although Multidisciplinary Team Management (MDT) is integrated in most international head and neck cancer treatment guidelines, its applications and proceedings were rarely described. The present study explores a 6-year real-life experience in a French Comprehensive Cancer Care Center.

Methods: Patients, tumor and meeting characteristics of all consecutive cases discussed in head and neck MDT meetings between 2010 and 2015 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.020DOI Listing

Time trends of thyroglobulin antibody in ablated papillary thyroid carcinoma patients: Can we predict the rate of negative conversion?

Oral Oncol 2019 Apr 26;91:29-34. Epub 2019 Feb 26.

Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea. Electronic address:

Objectives: Persistence of thyroglobulin antibody (TgAb) in patients with papillary thyroid carcinoma (PTC) years after total thyroidectomy (TT) followed by ablation occurs even without any evidence of structural disease. Few studies have studied the natural course of TgAb positivity and factors that may influence this course. The present study evaluated the time trends of TgAb in ablated PTC patients and aimed to identify the predictive factors for the rate of negative conversion of TgAb. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.022DOI Listing
April 2019
3 Reads

Differences of tumor-recruiting myeloid cells in murine squamous cell carcinoma influence the efficacy of immunotherapy combined with a TLR7 agonist and PD-L1 blockade.

Oral Oncol 2019 Apr 20;91:21-28. Epub 2019 Feb 20.

Department of Molecular Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan. Electronic address:

Objectives: The immune status of the tumor microenvironment has a marked impact on clinical outcomes. Here we examined the immune environments of tumor-infiltrating leukocytes (TILes) in two murine models of squamous cell carcinoma and compared the effects of immunotherapeutic agents, including a TLR7 agonist and an immune checkpoint inhibitor, and a chemotherapeutic agent, gemcitabine, in these models.

Materials And Methods: TILes from NR-S1- and SCCVII-grafted mice were analyzed by flow cytometry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375193005
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http://dx.doi.org/10.1016/j.oraloncology.2019.02.014DOI Listing
April 2019
5 Reads

Patient-reported outcomes of symptom burden in patients receiving surgical or nonsurgical treatment for low-intermediate risk oropharyngeal squamous cell carcinoma: A comparative analysis of a prospective registry.

Oral Oncol 2019 Apr 16;91:13-20. Epub 2019 Feb 16.

Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Purpose: To explore treatment-related changes in symptom burden and quality of life (QOL) in oropharyngeal squamous cell cancer (OPSCC) patients treated surgically and non-surgically.

Patients And Methods: Eighty-six patients with human papillomavirus-associated OPSCC treated at the Head and Neck Center at The University of Texas MD Anderson Cancer Center were recruited to a prospective registry study between 2014 and 2016 and completed the core, head and neck-specific, and symptom interference sections of the MD Anderson symptom inventory (MDASI) multi-symptom questionnaire and the EQ-5D health status assessment as a measure of QOL at four time points.

Results: Longitudinal improvements from post-treatment nadir were observed across all groups. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.020DOI Listing
April 2019
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Depicting distant metastatic risk by refined subgroups derived from the 8th edition nasopharyngeal carcinoma TNM.

Oral Oncol 2019 Apr 12;91:113-120. Epub 2019 Mar 12.

Department of Radiation Oncology, Fujian Medical University Cancer Hospital & Fujian Cancer Hospital, Fuzhou, China. Electronic address:

Background: Tumor-nodal-metastasis (TNM) is the most important survival predictor in nasopharyngeal carcinoma (NPC). Distant metastasis (DM) is the predominant failure pattern of NPC in the intensity-modulated radiotherapy (IMRT) era. The DM risk appears to be different for T-N subsets within the same clinical stage. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.021DOI Listing
April 2019
3.607 Impact Factor

Dilation after laryngectomy: Incidence, risk factors and complications.

Oral Oncol 2019 Apr 6;91:107-112. Epub 2019 Mar 6.

Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.

Background: Neopharyngeal stenosis is a recognized sequela of total laryngectomy (TL). We aim to investigate the incidence of stenosis requiring dilation, risk factors for stenosis and complications of dilation.

Methods: Retrospective cohort study of patients undergoing TL in two dedicated head and neck centers in the Netherlands. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.025DOI Listing
April 2019
1 Read
3.607 Impact Factor

Human papillomavirus detection in matched oral rinses, oropharyngeal and oral brushings of cancer-free high-risk individuals.

Oral Oncol 2019 Apr 13;91:1-6. Epub 2019 Feb 13.

STI/HIV Unit, San Gallicano Dermatologic Institute IRCCS, Via Elio Chianesi 53, 00144 Rome, Italy.

Objectives: The detection of oral Human Papillomavirus (HPV) may be of clinical utility because of the major role HPV plays in the etiology of oropharyngeal cancer. However, oral HPV testing is not standardized and the best sampling method has yet to be identified. We aimed to compare HPV findings in matched oral rinse-and-gargles (rinses), oropharyngeal brushings and oral brushings. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.002DOI Listing
April 2019
2 Reads

Oral tongue cancer in a patient with hereditary nonpolyposis colorectal cancer: A case report and review of the literature.

Oral Oncol 2019 Mar 15. Epub 2019 Mar 15.

Department of Otolaryngology, Loyola University Medical Center, Maywood, IL, United States.

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder characterized by mutations of mismatch repair genes leading to the early development of multiple malignancies. The most common malignancy is colorectal cancer but there is a strong association with malignancies of the ovary, endometrium, small intestine, stomach, skin, brain, and pancreas. We report a case of a 35-year-old female with a history of known HNPCC who presented with adenocarcinoma of the small intestine as well as a synchronous oral tongue squamous cell carcinoma. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.03.008DOI Listing
March 2019
1 Read

Ossified Carcinoma Ex Pleomorphic Adenoma in accessory lobe of parotid gland: Complexity in clinical, imaging and histologic diagnosis and minimally invasive surgery.

Oral Oncol 2019 Mar 7. Epub 2019 Mar 7.

Maxillofacial Surgery Unit, Department of Maxillo-Facial Surgery, University of Naples "Federico II", Naples, Italy. Electronic address:

Carcinoma ex pleomorphic adenoma is not common among malignant salivary tumors and an accessory lobe of parotid gland tumor with a carcinoma ex pleomorphic adenoma histology is even rarer. Management of these tumors include a high index of suspicion, good understanding of the anatomy and a meticulous surgical access. The exceptional localization of an ossified Carcinoma ex Pleomorphic Adenoma in the accessory lobe of the parotid gland, never reported to date in the literature, has prompted us to report this case to stress the challenging difficulties related to clinical and histologic diagnosis and to analyze a minimally invasive intraoral approach. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.03.003DOI Listing
March 2019
1 Read

Revisiting and revising the definition of oral submucous fibrosis.

Oral Oncol 2019 Mar 7. Epub 2019 Mar 7.

Department of Oral Pathology, Manipal College of Dental Sciences, Manipal Academy of Higher Education (MAHE), Manipal 576104, India. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2019.03.004DOI Listing

Corrigendum to "Long-term survival and late toxicities of elderly nasopharyngeal carcinoma (NPC) patients treated by high-total- and fractionated-dose simultaneous modulated accelerated radiotherapy with or without chemotherapy" [Oral Oncol. 89 (2019) 40-47].

Oral Oncol 2019 Mar 26;90:136. Epub 2019 Jan 26.

Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou 510060, China. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.030DOI Listing

Reprint of Long-term survival and late toxicities of elderly nasopharyngeal carcinoma (NPC) patients treated by high-total- and fractionated-dose simultaneous modulated accelerated radiotherapy with or without chemotherapy.

Oral Oncol 2019 Mar 25;90:126-133. Epub 2019 Jan 25.

Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou 510060, China. Electronic address:

Background: To analyse the survival and late toxicities of elderly nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiotherapy (IMRT) with the high-total- and fractionated-dose simultaneous modulated accelerated radiation therapy (SMART) boost technique and to identify the effect of concurrent chemotherapy for these patients.

Methods: Two hundred and fifty-four elderly patients (age ≥ 60.0) with newly diagnosed non-metastatic NPC were retrospectively analysed. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.005DOI Listing

A functional gene expression analysis in epithelial sinonasal cancer: Biology and clinical relevance behind three histological subtypes.

Oral Oncol 2019 Mar 11;90:94-101. Epub 2019 Feb 11.

Head and Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. Electronic address:

Epithelial sinonasal cancers (SNCs) are rare diseases with overlapping morphological features and a dismal prognosis. We aimed to investigate the expression differences among the histological subtypes for discerning their molecular characteristics. We selected 47 SNCs: (i) 21 nonkeratinizing squamous cell carcinomas (NKSCCs), (ii) 13 sinonasal neuroendocrine cancers (SNECs), and (iii) 13 sinonasal undifferentiated cancers (SNUCs). Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.003DOI Listing
March 2019
2 Reads

Elective neck dissection in oral squamous cell carcinoma: Past, present and future.

Oral Oncol 2019 Mar 10;90:87-93. Epub 2019 Feb 10.

Coordinator of the International Head and Neck Scientific Group, Italy.

In 1994 a decision analysis, based on the literature and utility ratings for outcome by a panel of experienced head and neck physicians, was presented which showed a threshold probability of occult metastases of 20% to recommend elective treatment of the neck. It was stated that recommendations for the management of the cN0 neck are not immutable and should be reconfigured to determine the optimal management based on different sets of underlying assumptions. Although much has changed and is published in the almost 25 years after its publication, up to date this figure is still mentioned in the context of decisions on treatment of the clinically negative (cN0) neck. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.016DOI Listing

A competing risk nomogram to predict severe late toxicity after modern re-irradiation for squamous carcinoma of the head and neck.

Oral Oncol 2019 Mar 8;90:80-86. Epub 2019 Feb 8.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, United States.

Purpose: Severe late toxicity is common after re-irradiation for recurrent or second primary (RSP) squamous carcinoma of the head and neck. However, many patients experience complications from tumor progression before manifesting late effects. We constructed a nomogram to examine this relationship between late toxicity and competing risks. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.022DOI Listing

Incidence, predictors and impact of positive bony margins in surgically treated T4 stage cancers of the oral cavity.

Oral Oncol 2019 Mar 28;90:8-12. Epub 2019 Jan 28.

Head and Neck Oncology Department, Tata Memorial Hospital, Mumbai, India. Electronic address:

Objectives: A sea of literature addressing the adequacy of mucosal/soft tissue surgical margins in oral cavity cancers is available, but no mention exists regarding bony margins. We aim to study the predictors and impact on survival of positive bony margins and propose a safe margin distance.

Methods: This is a retrospective study of 400 consecutive surgically treated pT4 oral cavity squamous cell carcinoma patients between January 2012 and December 2015. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.011DOI Listing
March 2019
3.607 Impact Factor

Real-time PCR HPV genotyping in fine needle aspirations of metastatic head and neck squamous cell carcinoma: Exposing the limitations of conventional p16 immunostaining.

Oral Oncol 2019 Mar 7;90:74-79. Epub 2019 Feb 7.

Department of Pathology, The Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States. Electronic address:

Background: Given the propensity for HPV-positive head and neck squamous cell carcinoma (HPV-HNSCC) to metastasize to cervical lymph nodes, fine needle aspiration (FNA) plays an important diagnostic role in their initial detection. Indeed, there is now an unwavering commitment to HPV testing of FNAs even in the absence of clear methodologic guidelines and threshold criteria. A particular difficulty pertains to the interpretation of p16 staining. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.006DOI Listing
March 2019
1 Read

The effects of checkpoint inhibition on head and neck squamous cell carcinoma: A systematic review.

Oral Oncol 2019 Mar 5;90:67-73. Epub 2019 Feb 5.

Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Denmark. Electronic address:

Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent malignancy worldwide. Immunotherapy with checkpoint inhibitors such as anti-CTLA-4 anti-PD-l and anti-PD-L1 has shown promising results in treating patients with recurrent/metastatic HNSCC. We aimed to systematically review the literature on immunotherapy with checkpoint inhibitors as treatment for advanced HNSCC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375193002
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http://dx.doi.org/10.1016/j.oraloncology.2019.01.018DOI Listing
March 2019
2 Reads

Organ preservation in laryngeal and hypopharyngeal cancer.

Authors:
Stephen Kang

Oral Oncol 2019 Mar 28;90:6-7. Epub 2019 Jan 28.

Division of Head and Neck Oncology, Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.014DOI Listing

Statin use associated with improved overall and cancer specific survival in patients with head and neck cancer.

Oral Oncol 2019 Mar 4;90:54-66. Epub 2019 Feb 4.

Department of Radiation Oncology, University of Colorado, Denver, United States. Electronic address:

Objectives: Studies have shown the utility of lipid-lowering agents in improving outcomes in various cancers. We aim to explore how statins affect overall survival and cancer specific survival in head and neck cancer patients using population-based datasets.

Patients And Methods: Using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked dataset, we separated HNC patients into three groups: those with no hyperlipidemia (nH), those with hyperlipidemia and not taking a statin (HnS), and those with hyperlipidemia and taking a statin (H + S). Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.019DOI Listing

The prevalence and impact of cervical spine pathologies in patients with nasopharyngeal carcinoma.

Oral Oncol 2019 Mar 1;90:48-53. Epub 2019 Feb 1.

Department of Orthopaedics and Traumatology, The University of Hong Kong, Pok Fu Lam, Hong Kong. Electronic address:

Objectives: Nasopharyngeal carcinoma (NPC) and its treatment can lead to cervical spine pathologies such as metastases, osteoradionecrosis (ORN) and infection. However, the occurrence rate and relationship between timing of diagnosis and outcomes of the ever-advancing technology of radiation therapy is largely unknown. Hence, the aim of this study is to determine the prevalence and impact of cervical spine pathologies in patients with NPC. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.013DOI Listing
March 2019
2 Reads

Cervical nodal metastasis after malignant conversion of sinonasal inverted papilloma: Report of a rare case and literature review.

Oral Oncol 2019 Mar 1;90:45-47. Epub 2019 Feb 1.

Augusta University, Department of Otolaryngology-Head and Neck Surgery, Augusta, GA 30912, United States.

Malignant conversion of sinonasal inverted papilloma (SNIP) occurs in approximately ten percent of cases. These tumors are classically described as locally destructive, but without metastatic potential. Only four cases of malignant conversion with cervical nodal metastases have been described in the English literature. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.024DOI Listing
March 2019
1 Read

Direct and antibody-dependent cell-mediated cytotoxicity of head and neck squamous cell carcinoma cells by high-affinity natural killer cells.

Oral Oncol 2019 Mar 1;90:38-44. Epub 2019 Feb 1.

Translational Tumor Immunology Program, National Institutes on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, United States; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States. Electronic address:

High affinity natural killer cells (haNKs) are a cell therapy product capable of mediating both direct and antibody-dependent cell-mediated cytotoxicity (ADCC). These cells may be particularly useful in tumors that escape T-cell anti-tumor immunity by harboring antigen processing and presentation defects. Here, we demonstrated that haNKs directly kill both HPV-positive and negative head and neck squamous cell carcinoma cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375193002
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http://dx.doi.org/10.1016/j.oraloncology.2019.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410731PMC
March 2019
8 Reads
3.607 Impact Factor

Prognostic value of programed death ligand-1 and ligand-2 co-expression in salivary gland carcinomas.

Oral Oncol 2019 Mar 1;90:30-37. Epub 2019 Feb 1.

Department of Head and Neck Surgery, National Kyushu Cancer Center, Notame 3-1-1, Minami-ku, Fukuoka 811-1395, Japan. Electronic address:

Objectives: The aim of the present study was to investigate the molecular basis for the use of immune checkpoint inhibitors to treat salivary gland carcinomas (SGC).

Materials And Methods: We examined the clinical and prognostic significance of programed death ligands 1 and 2 (PD-L1 and -L2) expression using immunohistochemistry and in situ hybridization, as well as microsatellite instability (MSI) status using polymerase chain reaction, along with tumor-infiltrating lymphocytes (TILs) in 30 cases of SGC.

Results: The SGC cases studied included adenoid cystic carcinoma (AdCC, 36. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.015DOI Listing
March 2019
2 Reads

Effect of prior cancer on trial eligibility and treatment outcomes in nasopharyngeal carcinoma: Implications for clinical trial accrual.

Oral Oncol 2019 Mar 1;90:23-29. Epub 2019 Feb 1.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510060, People's Republic of China. Electronic address:

Objective: In cancer trials, prior cancer is a common exclusion criterion. We evaluated the characteristics of prior cancer exclusion criteria in nasopharyngeal carcinoma (NPC) trials and determined its prognostic effect on patients with NPC.

Methods: We reviewed NPC trials for prior cancer exclusion criteria. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.023DOI Listing
March 2019
2 Reads

Total thyroidectomy versus lobectomy for intermediate-risk papillary thyroid carcinoma: A single-institution matched-pair analysis.

Oral Oncol 2019 Mar 31;90:17-22. Epub 2019 Jan 31.

Department of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center For Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing, China. Electronic address:

Background: Total thyroidectomy (TT) is recommended by guidelines for intermediate-risk papillary thyroid carcinoma (PTC) but its survival advantage over lobectomy has not been proven. The aim of this study was to examine the association between the extent of surgery and the clinical outcome of patients with intermediate-risk PTC.

Methods: Adult patients with PTC in the institutional database from 1996 to 2008 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.010DOI Listing
March 2019
1 Read

Computed tomography evaluation after induction chemotherapy for T3 laryngeal cancer: Does response correlate with vocal cord mobility?

Oral Oncol 2019 Mar 28;90:13-16. Epub 2019 Jan 28.

Department of Diagnostic Radiology, Gustave Roussy, Villejuif F-94800, France; IR4M (UMR8081), Université Paris-Sud, Centre National de la Recherche Scientifique, Orsay 91471, France. Electronic address:

Objectives: After induction chemotherapy (IC) for laryngeal cancer, Computed Tomography (CT) is used to assess tumor response but lacks rationalized methods for measurement of this response. In T3 laryngeal cancer, remobilization of an initially fixed vocal cord (VC) is a major sign of tumor response. We compared the performances of RECIST1. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.009DOI Listing

Survival outcomes after treatment of cancer of the oral cavity (1985-2015).

Oral Oncol 2019 Mar 15;90:115-121. Epub 2019 Feb 15.

Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA. Electronic address:

Objectives: To present treatment results of oral squamous cell carcinoma (OSCC) at a tertiary cancer care center from 1985 to 2015.

Materials And Methods: A total of 2082 patients were eligible for this study. Main outcomes measured were overall survival (OS) and disease specific survival (DSS). Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417804PMC
March 2019
1 Read

Atorvastatin increases oxidative stress and inhibits cell migration of oral squamous cell carcinoma in vitro.

Oral Oncol 2019 Mar 12;90:109-114. Epub 2019 Feb 12.

Genetics and Molecular Biology Research Unit (UPGEM), São José do Rio Preto Medical School (FAMERP), Av Brigadeiro Faria Lima, 5416, 15090-000, São José do Rio Preto, SP, Brazil.

Objective: This study aimed to evaluate the effect of atorvastatin treatment on reactive oxygen species (ROS) production and tumor angiogenesis in oral squamous cell carcinomas.

Material And Methods: An HN13 cell line was treated with 1 µM, 5 µM, and 10 µM of atorvastatin. VEGF-A gene expression was evaluated by quantitative real time PCR. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.025DOI Listing
March 2019
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Associations between pre-, post-, and peri-operative variables and health resource use following surgery for head and neck cancer.

Oral Oncol 2019 Mar 11;90:102-108. Epub 2019 Feb 11.

Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Objective: We examined associations between pre-, post-, and peri-operative variables and health resource use in head and neck cancer patients.

Methods: Patients (N = 183) who were seen for a pre-surgical consult between January 2012 and December 2014 completed surveys that assessed medical history, a patient-reported outcome measure (PROM) of dysphagia, and quality of life (QOL). After surgery, peri-operative (e. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410733PMC
March 2019
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Number of positive nodes - Current relevance in determining prognosis of oral cavity cancer after the recent AJCC staging update.

Oral Oncol 2019 Mar 23;90:1-5. Epub 2019 Jan 23.

Department of Surgical Oncology - Rajiv Gandhi Cancer Institute & Research Centre, Delhi, India.

Introduction: Lymph node involvement and the number of positive nodes is a significant prognosticator in oral cavity cancers and current staging system does not incorporate it as an integral part.

Material And Methods: This was a retrospective study of oral cavity cancer patients who were operated during the time period of 2009-2017. The data was collected and analysed to assess the impact of increase in the number of positive nodes on survival and its comparison of survival statistics to current AJCC staging. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.001DOI Listing
March 2019
3.607 Impact Factor

Trastuzumab-based therapy is effective for salivary duct carcinoma: Case report and review of the literature.

Oral Oncol 2019 Apr 1;91:121-122. Epub 2019 Mar 1.

Department of Otorhinolaryngology, Second Clinical Medicine College of Jinan University, Shenzhen People's Hospital, China.

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.015DOI Listing

Corrigendum to 'Primary thyroid angiosarcoma: A systematic review' [Oral Oncol. 82 (2018) 48-52].

Oral Oncol 2019 Apr 26;91:137. Epub 2019 Feb 26.

Department of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.016DOI Listing

Squamous cell carcinoma around a dental implant: A case report and literature review.

Oral Oncol 2019 Apr 22;91:134-136. Epub 2019 Feb 22.

LBN, Faculty of Dentistry, University of Montpellier, 545 av du Pr JL Viala, 34193 Montpellier Cedex 5, France. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.005DOI Listing

Prognostic significance of Lymph Node Ratio (LNR): Clinical insights and strategies for routine clinical practice.

Oral Oncol 2019 Apr 18;91:125-127. Epub 2019 Feb 18.

Head of Department, Department of Biochemistry, Bharathiar University, Coimbatore, Tamil Nadu, India.

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.012DOI Listing
April 2019
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3.607 Impact Factor

The need for combination immunotherapy in oncology.

Oral Oncol 2019 Apr 18;91:123-124. Epub 2019 Feb 18.

Regenerative Medicine Laboratory, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, India.

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.013DOI Listing
April 2019
3.607 Impact Factor

Can topical 5-fluorouracil be used as a viable treatment option for oral premalignant lesions and tumors?

Oral Oncol 2019 Apr 15;91:128. Epub 2019 Feb 15.

Department of Oral and Maxillofacial Surgery, Kothiwal Dental College and Research Centre, Moradabad, India.

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.009DOI Listing

Successful treatment with trastuzumab in HER2-positive squamous cell carcinoma of the head and neck.

Oral Oncol 2019 Apr 14;91:129-131. Epub 2019 Feb 14.

Department of Head and Neck Cancer, Gustave Roussy Cancer Campus, Villejuif, France.

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.008DOI Listing