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Minerva Stomatol 2018 Dec 14. Epub 2018 Dec 14.

Periodontics and Implantology School of Dentistry and Oral Health, Griffith University, Gold Coast, Queensland, Australia -

Methods Mol Biol 2019 ;1894:1-29

Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA.

As a consequence of their increase in annual production and widespread distribution in the environment, nanoparticles potentially pose a significant public health risk. The sought-after catalytic activity granted by their physiochemical properties doubles as a hazard to physiological processes following exposure through inhalation, oral, transdermal, subcutaneous, and intravenous uptake. Upon uptake into the body, their size, morphology, surface charge, coating, and chemical composition augment the response of biological systems to the materials and enhance their toxicity. Read More

Indian J Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Division of Neonatology, Department of Pediatrics, Newborn Health Knowledge Centre, All India Institute of Medical Sciences, New Delhi, 110029, India.

Objective: To evaluate the feeding performance of infants with bronchopulmonary dysplasia (BPD) on paladai.

Methods: This cross-sectional study was performed in a level III neonatal unit in North India from March through August 2012. Nineteen infants (27-32 wk of gestation) were enrolled; 9 in BPD group (oxygen requirement for at least 28 d) and 10 in 'No BPD' group. Read More

Can J Anaesth 2018 Dec 13. Epub 2018 Dec 13.

Emergency and Essential Surgical Care Programme, World Health Organization, Geneva, Switzerland.

Support Care Cancer 2018 Dec 13. Epub 2018 Dec 13.

Department of Pharmacy, Osaka City University Hospital, 1-5-7 Asahi-machi, Abeno-ku, Osaka, 545-8586, Japan.

Purpose: The purpose of this study was to compare the efficacy of the pre-prescription of garenoxacin mesylate hydrate (GRNX) with that of moxifloxacin hydrochloride (MFLX) in the management of breast cancer patients with low-risk febrile neutropenia.

Methods: Data from female patients who had been instructed to take previously prescribed oral GRNX or MFLX for 3 days during adjuvant and neoadjuvant chemotherapy if their body temperature exceeded 38 °C were analyzed. This study compared the effectiveness between these fluoroquinolones using a propensity score matching analysis. Read More

Open Forum Infect Dis 2018 Dec 17;5(12):ofy306. Epub 2018 Nov 17.

The National Centre for Infections in Cancer, Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

Antibiotic allergies are reported by up to 1 in 4 cancer patients, almost 50% of which are considered low risk and precede the cancer diagnosis. We demonstrate the successful and safe implementation of a pilot oral penicillin challenge program for cancer patients with low-risk penicillin allergies, increasing the use of penicillin and narrow-spectrum beta-lactams post-testing. Read More

Front Public Health 2018 27;6:342. Epub 2018 Nov 27.

Collaboration for Evidence, Research and Impact in Public Health, School of Public Health, Curtin University, Bentley, WA, Australia.

Since the emergence of the HIV pandemic in the 1980s, high rates of condom use for penetrative sex have been reported among sex workers in Australia. The sex industry in Australia and elsewhere has changed over the previous decade with increasing proportions of sex workers working privately and lower proportions of sex workers working in brothels. There has also been some evidence of reductions in condom use, particularly during penetrative oral sex. Read More

J Orthod Sci 2018 15;7:23. Epub 2018 Nov 15.

Department of Oral Rehabilitation Sciences, Faculty of Dentistry, Beirut Arab University, Lebanon.

Objective: To evaluate the effect of different surface treatments and bonding modalities on the shear bond strength (SBS) between metallic orthodontic brackets and zirconia crowns.

Materials And Methods: Sixty zirconia specimens were computer-aided design/computer-aided manufacturing milled, sintered, glazed, and embedded in acrylic resin. The specimens were divided into three groups according to the surface treatment applied: C: no surface treatment (control), S: sandblasted with 50 μm AlO, and D: Sof-Lex disc roughening. Read More

J Orthod Sci 2018 15;7:21. Epub 2018 Nov 15.

Department of Orthodontics, Oman Dental College, Muscat, Oman.

Objective: To determine the prevalence of malocclusion and orthodontic treatment need in a sample of Omani adolescents aged 11-16 years.

Materials And Methods: The total sample included 854 adolescents with 387 boys and 467 girls between the age of 11 and 16 years with no previous orthodontic treatment history. The study design was cross-sectional. Read More

J Orthod Sci 2018 15;7:20. Epub 2018 Nov 15.

Division of Orthodontics, School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Objectives: To evaluate the possible change in teeth lengths as an indicator of orthodontically induced tooth root resorption (OITRR) after high-frequency mechanical vibration (HFV) treatment concurrent with Invisalign Smart Track® aligners as evaluated by cone beam computed tomography (CBCT).

Materials And Methods: The sample, composed of 30 patients with an average age of 26 ± 11 years and Class I malocclusion with an initial anterior crowding ranging from 3 to 5 mm, was divided equally into two groups; Group I received adjunctive high-frequency mechanical vibration (HFV); Group II, the control, did not receive adjunctive mechanical treatment. The maxillary incisor's teeth lengths were measured using Mimics software before (T1) and after (T2) treatment. Read More

J Oral Biol Craniofac Res 2019 Jan-Mar;9(1):111-114. Epub 2018 Nov 30.

Dept. of Public Health Dentistry at Yogita Dental College and Hospital, Khed, Ratnagiri, Maharashtra, India.

Purpose: To evaluate and compare the soft tissue anaesthesia produced by tramadol hydrochloride on gingival tissues in maxilla.

Methods: A total of 50 ASA physical status I subjects between 18 and 35 years of age, both male and female were included in the study. Each individual received 0. Read More

Cureus 2018 Oct 8;10(10):e3428. Epub 2018 Oct 8.

Ophthalmology, School of Medical Sciences/Universiti Sains Malaysia, Kota Bharu, MYS.

In human, sporotrichosis infection commonly manifests as skin lesions through direct inoculation. It is rarely associated with ocular manifestation via a zoonotic transmission. We describe a young lady who presented with acute left eye granulomatous conjunctivitis who had a history of exposure to her sick cat diagnosed with sporotrichosis infection. Read More

Mol Clin Oncol 2018 Dec 5;9(6):702-704. Epub 2018 Oct 5.

Department of Sense Organs, Sapienza University of Rome, I-00186 Rome, Italy.

'Juvenile' nasopharyngeal angiofibroma, which accounts for <1% of all head and neck neoplasms, occurs predominantly in males between 10 and 18 years of age. The small number of patients older than 30 years confirms that presentation after this age is exceptional. Only rare cases of nasopharyngeal angiofibroma in female patients have been documented to date, and some authors believe that sex chromosome studies are indicated in such cases. Read More

Biomed Rep 2018 Dec 23;9(6):474-482. Epub 2018 Oct 23.

Clinical Pharmacy, Riau Islands General Hospital, Tanjung Pinang, Riau Islands 29125, Indonesia.

Red ginger ( var. Rubrum) is among the most widely consumed medicinal herbs in Indonesia. Ginger rhizome contains phenol compounds including gingerol and shogaol. Read More

J Glob Health 2019 Jun;9(1):010501

Clinton Health Access Initiative, New Delhi, India.

Background: The Clinton Health Access Initiative implemented a program from 2012-2016 to increase use of oral rehydration salts (ORS) and zinc to treat diarrhea in children under five in three states in India: Gujarat, Madhya Pradesh, and Uttar Pradesh. The program interventions included detailing and development of a rural supply chain to reach private rural health care providers, training of Accredited Social Health Activists (ASHAs), technical support to the state governments, and a mass media campaign targeted at caregivers. In Gujarat and Uttar Pradesh, some of the program activities, such as detailing and ASHA trainings, were targeted to high-burden focal districts, thus providing an opportunity to study their effect compared to statewide activities that covered all districts, such as the mass media campaign. Read More

Oncol Lett 2018 Dec 27;16(6):6930-6939. Epub 2018 Sep 27.

Biotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou, Guangdong 510632, P.R. China.

is widely used as a traditional Chinese medicine health supplement, and is also used in the development of anticancer agents. In our previous studies, it was revealed that fraction (CMF) possessed an antitumor effect against K562 cells , induced apoptosis and caused cell cycle arrest in the S phase. The published results also demonstrated that CMF-induced apoptosis was involved in mitochondrial dysfunction. Read More

Exp Ther Med 2018 Dec 19;16(6):4445-4456. Epub 2018 Sep 19.

Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.

Food allergy prevalence has steadily increased worldwide over the past decades and immunotherapeutic treatment strategies are gaining attention. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) exhibit similar immune regulatory properties to bone marrow-derived MSCs. hUC-MCSs can be prepared with fewer ethical constraints and are potential candidates for allergic disorder therapies. Read More

Front Neurol 2018 28;9:1028. Epub 2018 Nov 28.

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Pregnancy in patients with necrotizing autoimmune myopathy without identified antibodies is rarely reported. We report a case involving a 26-year-old woman with antibody-negative autoimmune necrotizing myopathy who experienced a relapse during pregnancy. Before pregnancy, the patient's myopathy symptoms and elevated serum creatine kinase levels had been successfully controlled with oral prednisone and tacrolimus for 1 year. Read More

Front Psychol 2018 28;9:2300. Epub 2018 Nov 28.

Laboratoire de Sciences Phonétiques, Département de Linguistique, Université de Montréal, Montreal, QC, Canada.

Why does symbolic communication in humans develop primarily in an oral medium, and how do theories of language origin explain this? Non-human primates, despite their ability to learn and use symbolic signs, do not develop symbols as in oral language. This partly owes to the lack of a direct cortico-motoneuron control of vocalizations in these species compared to humans. Yet such modality-related factors that can impinge on the rise of symbolic language are interpreted differently in two types of evolutionary storylines. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):229-231

Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Cysticercosis in human is caused by larva of cyclophyllid cestode named . Worm infestation is quite common in developing countries due to poor sanitation, habit of open defection. This condition primarily involves central nervous system. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):225-228

Department of Prosthodontics, Christian Dental College, Ludhiana, Punjab, India.

Squamous cell carcinoma (SCC) of the oral cavity is relatively common in the Indian subcontinent with surgical resection and adjuvant radiotherapy/chemotherapy being the treatment modality of choice. Prosthetic rehabilitation with an obturator following resection is more economical and yields satisfactory results. Better patient acceptance and comfort necessitates hollowing the prosthesis to a great extent. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):222-224

Department of Gynaecology and Obstetrics, Apollo Institute of Medical Sciences, Hyderabad, Telangana, India.

Large defect of the lip and buccal mucosa created due to wide resection of the cancer is difficult to reconstruct and always a challenge. Such defects are complex as there is loss of outer skin, muscle, soft tissue, and inner mucosal lining. We report the use of submental artery island flap (SAIF) in the reconstruction of a large defect of oral commissure and buccal mucosa in a 70-year-old female with the diagnosis of verrucous carcinoma. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):215-221

Department of Oral and Maxillofacial Surgery, Army College of Dental Sciences, Secunderabad, Telangana, India.

Aim: The aim of this study was to describe the characteristics of the mandibular third molar at highest risk for acute pericoronitis using clinical and radiographic analysis.

Materials And Methods: A total of 120 patients ranging in age from 18 to 55 years suffering from pericoronitis were examined. Subjective and objective observations were recorded that included the age, gender, angulation of partially impacted mandibular third molar, the frequency of pericoronitis in a year, the presence of impinging maxillary third molar, the extent of soft tissue coverage over the impacted mandibular third molar, the clinical signs evaluated in the patient, the class and position of the impacted mandibular third molar, and the presence of distal radiolucency with respect to the impacted mandibular third molar. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):209-214

Department of Prosthodontics, Crowns and Bridges, King George's Medical University, Lucknow, Uttar Pradesh, India.

Purpose: The aim is to evaluate the outcome and compare the stability with two-time use of platelet-rich growth factor (PRGF) versus one-time use of PRGF in immediate placement of dental implant in infected socket.

Materials And Methods: This study comprised placement of immediate implant in infected sockets in 100 patients with two-time use of PRGF (Group B) versus one-time use of PRGF (Group A). Proper administration of antibiotics, careful debridement of the socket, and meticulous suturing were done in every case. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):205-208

Department of Oral and Maxillofacial Surgery, Jaipur Dental College, Jaipur, Rajasthan, India.

Introduction: Temperomandibular joint (TMJ) is subjected to many disorders commonly called Temperomandibular disorders (TMDs); such as TMJ hypermobility, ankylosis, internal derangement, degenerative joint disease. Internal derangement is characterized by abnormal relationship of articular disc to the condyle and disc to fossa. In past many non-invasive conservative treatment modalities were tried out for its treatment which are joint unloading, use of anti-inflammatory agents, physiotherapy etc. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):191-195

Department of Surgical Oncology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Background: Oral cancers are some of the most common cancers in India. Most patients present with locally advanced disease requiring extensive resection resulting in large defects. Reconstruction of these defects plays a major role in restoring form and function to these patients, as well as enabling the delivery of adjuvant therapy on time. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):184-190

Department of Oral Medicine and Radiology, Pacific Dental College, Udaipur, Rajasthan, India.

Introduction: Oral leukoplakia, oral submucous fibrosis, and oral lichen planus are the precancerous or potentially malignant lesions and conditions whereas oral squamous cell carcinoma (OSCC) is a cancerous or malignant lesion of the oral cavity. They have characteristic clinical and histopathological features. These diseases not only originate from epithelium but also associated with chronic inflammation juxta-epithellialy. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):174-183

Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, IMS, BHU, Varanasi, Uttar Pradesh, India.

Aim And Objectives: The aim is to know the augmented new bone formation in postsurgical bony defects in the maxillofacial region when filled with plasma-enriched demineralized freeze-dried bone allograft (DFDBA).

Materials And Methods: The study group included 45 patients, selected randomly, and divided in three equated groups. In Group I (control) patients, the wound was closed primarily without incorporating any graft in the bony defect. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):167-173

Department of Oral and Maxillofacial Surgery, All India Institute of Medical Sciences, New Delhi, India.

Purpose: We describe the piezo-osteotomy feasibility in rehabilitation and harvesting of osteo-odonto lamina in modified osteo-odonto keratoprosthesis (MOOKP) surgery. Surgery was evaluated regarding operative technique and success of the keratoprosthesis (KPros) in terms of perception to light (+ve) to finger counting (+ve).

Materials And Methods: This retrospective cohort study included 12 patients undergone MOOKP surgery procedures. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):160-166

Department of Oral Pathology and Microbiology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Introduction: Cancer of oral cavity is the uncontrolled expansion of damaged cell within the mouth cavity. 5-fluorouracil (5-FU) chemotherapy was focused to kill the cancer cell, but it would affect the surrounding normal cells during oral cancer treatment. This study included the evaluation of chemoprotective effects of curcumin (CU), as an herbal remedy, on 5-FU-induced-cytotoxicity toward oral cancer treatment, loaded within a nanocarrier system. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):155-159

Department of Public Health Dentistry, ESIC Dental College and Hospital, Rohini, Delhi, India.

Aims And Objectives: Aims and objectives of the study were to study the effectiveness of Raj-yoga meditation and pranayama in patients with myofascial pain dysfunction syndrome (MPDS) and compared the effects with ongoing conventional noninvasive treatment modalities.

Materials And Methods: The study comprised 30 patients divided equally (10 each) into 3 group, i.e. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):147-154

Department of Oral Medicine and Radiology, D J College of Dental Sciences and Research, Ghaziabad, Uttar Pradesh, India.

Aim And Objectives: The aim and objectives of this study are to investigate the various types of stress-inducing factors, most prevalent etiological factor and to determine the correlation between stress and temporomandibular disorders (TMDs) in Dental students in Modinagar, Ghaziabad, Uttar Pradesh.

Materials And Methods: A sample of 450 students were selected for the study divided into two groups of undergraduate (UG) and postgraduate (PG) students further subdivided into UG (1, 2, 3, and 4, interns) and PG (1, 2, 3 year). Study includes clinical evaluation of temporomandibular joint (TMJ) system (TMJ sounds, muscles of mastications, mouth opening, and range of mandibular motion) and questionnaire which covers demographic data (i. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):140-146

Department of Oral and Maxillofacial Surgery, Sri Ramakrishna Dental College and Hospital, Coimbatore, Tamil Nadu, India.

Aim: This study was to evaluate and compare the bone regeneration potential of autologous platelet-rich fibrin (PRF) placed in one of the extracted sockets after the surgical removal of bilateral impacted mandibular third molars.

Patients And Methods: Twenty-five patients (10 females and 15 males; 18-35 years old) were taken for surgical removal of bilateral impacted mandibular third molar, performed in the same session. The autologous PRF was placed in one of the extracted sockets whereas the opposite side was taken as control side, and primary closure was done. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):134-139

Department of Oral and Maxillofacial Surgery, K.M. Shah Dental College, Vadodara, Gujarat, India.

Aim: This study aimed to evaluate the efficacy of intermaxillary fixation (IMF) screws and modified arch bar.

Materials And Methods: This study is a randomized clinical trial in which all participants were divided into two groups of ten in each group and designated as Group A and Group B. In Group A, IMF was achieved by the use of four to six 2×8mm stainless steel IMF screws. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):129-133

Department of Oral Medicine and Radiology, Career Post Graduate Institute of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India.

Introduction: The lingula is used for identifying the site for injection of local anesthetics and for excision of nerve in facial neuralgia. The relationship between lingula and lingual nerves may aid in risk associated with an impacted third molar. Due to its connection to nerve and vascular structures, the study of the lingula provides important information related to oral and maxillofacial surgical procedures, such as the sagittal split ramus osteotomy and the intraoral vertico-sagittal ramus osteotomy carried out to correct dento facial deformities. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):123-128

Department of Oral Medicine and Radiology, Faculty of Dental Sciences, King George's Medical University, Lucknow, Uttar Pradesh, India.

Background: Injuries of the maxillofacial complex represent one of the most important health problems worldwide. At present, in developing India, due to poor traffic sense, maxillofacial trauma and fractures are most epidemiologic diseases. Mandible is the largest and strongest facial bone and it is the second most commonly fractured bone. Read More

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):115-116

Department of Oral and Maxillofacial Surgery, SCB Dental College and Hospital, Cuttack, Odisha, India. E-mail:

J Conserv Dent 2018 Nov-Dec;21(6):627-631

Department of Restorative Dentistry, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.

Objectives: The specific objective of this study was to determine whether the current flowable resin composites can establish an effective seal in repairing noncarious amalgam margin defects.

Material And Methods: A total of 30 freshly extracted caries-free human third molars were used for this investigation. Class I preparations with a standardized 160-μ marginal defect were made by condensing amalgam against a Mylar strip. Read More

Nat Rev Microbiol 2018 Dec 13. Epub 2018 Dec 13.

Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Fusobacterium nucleatum has long been found to cause opportunistic infections and has recently been implicated in colorectal cancer; however, it is a common member of the oral microbiota and can have a symbiotic relationship with its hosts. To address this dissonance, we explore the diversity and niches of fusobacteria and reconsider historic fusobacterial taxonomy in the context of current technology. We also undertake a critical reappraisal of fusobacteria with a focus on F. Read More

Oncogene 2018 Dec 13. Epub 2018 Dec 13.

Department of Head and Neck Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

γδ T cells are a unique lymphocyte population that have been reported to have either anti- or pro-tumoral functions in several cancer types, but the mechanisms are underinvestigated. Exosomes, initially considered to be cellular "garbage dumpsters," are now implicated in mediating interactions with the cellular environment. Hypoxia is a common feature of solid tumors and is believed to alter tumor-derived exosomes (TEXs), which mediate the hypoxic evolution of the tumor microenvironment in return. Read More

J Natl Compr Canc Netw 2018 Dec;16(12):1491-1498

Scientific Center for Quality of Healthcare, and Department of Otolaryngology, Head and Neck Surgery, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen; Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, Rotterdam; Department of Medical Oncology, Antoni van Leeuwenhoek Nederlands Kanker Instituut, Amsterdam; Department of Oral and Maxillofacial Surgery, Rijnstate Hospital, Arnhem; Department of Oral and Maxillofacial Surgery, Noordwest Ziekenhuisgroep, Alkmaar; Department of Oral and Maxillofacial Surgery, Maastricht University Medical Center, Maastricht; Department of Research, Netherlands Comprehensive Cancer Organisation, Utrecht; Department of Epidemiology, University of Groningen, University Medical Centre Groningen, Groningen; Department of Head and Neck Surgical Oncology, UMC Utrecht Cancer Centre, Utrecht; Department of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht; Department of Oral and Maxillofacial Surgery, Medisch Spectrum Twente, Enschede; Department of Otolaryngology, Head and Neck Surgery, Elisabeth Tweesteden Ziekenhuis Tilburg, Tilburg; Department of Otorhinolaryngology, Head and Neck Surgery, Leiden University Medical Centre, Leiden; Department of Otolaryngology, Head and Neck Surgery, MC Haaglanden-Bronovo, The Hague; Department of Oral and Maxillofacial Surgery, Medical Centre Leeuwarden, Leeuwarden; Department of Otolaryngology, Head and Neck Surgery, VU University Medical Centre, Amsterdam; Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Centre Groningen, Groningen; Department of Head and Neck Surgery and Oncology, Antoni van Leeuwenhoek Nederlands Kanker Instituut, Amsterdam; Department of Oral and Maxillofacial Surgery, Academisch Medisch Centrum, Amsterdam Zuid-Oost; and Department of Oral and Maxillofacial Surgery, Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, the Netherlands.

Monitoring and effectively improving oncologic integrated care requires dashboard information based on quality registrations. The dashboard includes evidence-based quality indicators (QIs) that measure quality of care. This study aimed to assess the quality of current integrated head and neck cancer care with QIs, the variation between Dutch hospitals, and the influence of patient and hospital characteristics. Read More

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

Dept of Cardiology, Erasme University Hospital, Brussels, Belgium.

The function of the right ventricle determines the fate of patients with pulmonary hypertension. Since right heart failure is the consequence of increased afterload, a full physiological description of the cardiopulmonary unit consisting of both the right ventricle and pulmonary vascular system is required to interpret clinical data correctly. Here, we provide such a description of the unit and its components, including the functional interactions between the right ventricle and its load. Read More

J Lipid Res 2018 Dec 13. Epub 2018 Dec 13.

University of Pittsburgh, United States.

Electrophilic nitro-fatty acids (NO2-FA) showed beneficial signaling actions in preclinical studies, and safety in Phase 1 clinical trials. Detailed understanding of the pharmacokinetics (PK) of NO2-FA is complicated by the capability of electrophilic fatty acids to alkylate thiols reversibly, become esterified in various complex lipids, and the instability of the nitroalkene moiety during enzymatic and base hydrolysis. Herein, we report the mechanism and kinetics of absorption, metabolism, and distribution of the endogenously-detectable and prototypical NO2-FA 10-nitro-oleic acid (10-NO2-OA) in dogs after oral administration. Read More

Prim Care Diabetes 2018 Dec 10. Epub 2018 Dec 10.

Department of Community Medicine, Pt. B. D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.

Objective: To develop a simplified scoring system for detecting undiagnosed prediabetes among healthy adult population of Haryana, India.

Material & Methods: This cross-sectional study was a household survey which involved 892 healthy adults >18year of age who were subjected to an oral glucose tolerance test. Sensitivity, specificity, positive and negative predictive value and area under the receiver operating characteristic (ROC) curve and the optimal cut off points for identifying undiagnosed prediabetes were calculated. Read More

Lancet 2018 Dec 10. Epub 2018 Dec 10.

Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Background: Maintenance therapy following autologous stem cell transplantation (ASCT) can delay disease progression and prolong survival in patients with multiple myeloma. Ixazomib is ideally suited for maintenance therapy given its convenient once-weekly oral dosing and low toxicity profile. In this study, we aimed to determine the safety and efficacy of ixazomib as maintenance therapy following ASCT. Read More

Lancet 2018 Dec 10. Epub 2018 Dec 10.

Department of Haematology, University College London, London, UK.

Enferm Infecc Microbiol Clin 2018 Dec 10. Epub 2018 Dec 10.

Servicio de Microbiología Oral, Clínica Odontológica de la Corporación Universitaria Rafael Núñez, Cartagena, Colombia.

Objective: Tdescribe the bacterial profile of the supragingival biofilm of children with temporary dentition (CTD) and early mixed dentition (CEMD), with the next-generation sequencing (HOMINGS) technique.

Method: A comparative descriptive study was carried out with 30 systemically healthy children aged between 5 and 7 years old from public schools in Cartagena-Colombia. All participants were caries-free applying the criteria of the International Caries Detection and Assessment System (ICDAS II) and had no caries experience according to the Decayed, Missing and Filled Teeth (DMFT) index. Read More

Biochem Biophys Res Commun 2018 Dec 10. Epub 2018 Dec 10.

Department of Cellular Physiological Chemistry, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. Electronic address:

Epithelial-to-mesenchymal transition (EMT) is the process in which epithelial cells lose cell polarity and cell adhesion with surrounding cells to obtain migratory and invasive abilities. On the other hand, the expression of connexin is decreased or lacked in the many types of tumor cells. This study examined the effect of gap junctional intercellular communication (GJIC) on EMT induced by the transforming growth factor-β1 (TGF-β1). Read More

Biochem Biophys Res Commun 2018 Dec 10. Epub 2018 Dec 10.

Department of Oral & Maxillofacial Pathobiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan. Electronic address:

Osteosarcoma (OS) is one the most common primary malignancies of the bone in children and young adults with high metastasis. The use of non-toxic naturally derived compounds is one of present strategies in OS therapy to reduce secondary effects and chemo-resistance. Lactoferrin (LF), a transferrin protein derived from milk, currently appears to be an anticancer agent. Read More

Dent Mater 2018 Dec 10. Epub 2018 Dec 10.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, 237# Luoyu Road, Wuhan 430079, China. Electronic address:

Objective: The aim of this study was to evaluate the effect of conditioning solutions containing DL-aspartic amino (Asp) on dentine remineralization induced by bioactive glass 45S5 (BAG) in a simulated oral environment.

Methods: Sixty dentine discs from human third molars were used. Dentine specimens were treated with ethylene diamine tetraacetic acid (EDTA) to create a partially demineralization model and randomly divided to 4 groups: Artificial saliva (AS) group, Asp group (pretreated with Asp and remineralized with distilled water), BAG group (pretreated with distilled water and remineralized by BAG), Asp-BAG group (pretreated with Asp and remineralized by BAG). Read More