1,111 results match your criteria Oral Nevi


[Medicaments and oral healthcare. Hyperpigmentation of oral soft tissues due to afamelanotide].

Ned Tijdschr Tandheelkd 2020 Apr;127(4):237-243

The medicament afamelanotide is an analogue of endogenous ?-melanocyte-stimulating hormone. It promotes cutaneous pigmentation, providing protection from sunlight. In dermatology, afamelanotide seems to establish therapeutic results for polymorphic light eruption, solar urticaria, erythropoietic protoporphyria, Hailey-Hailey disease, vitiligo and acne vulgaris. Read More

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http://dx.doi.org/10.5177/ntvt.2020.04.19115DOI Listing

Giant congenital melanocytic nevus of the scalp: from clinical-histological to molecular diagnosis.

Hereditas 2020 May 19;157(1):21. Epub 2020 May 19.

Department of Plastic and Reconstructive Surgery, Shanghai 9th Peoples Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

Congenital melanocytic nevus (CMN) is a benign proliferative skin disease in the epidermis and dermis. Large to giant CMNs are estimated to be associated with an increased lifetime risk of malignancy. It is necessary to estimate and monitor the risk of malignant transformation for giant CMNs. Read More

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http://dx.doi.org/10.1186/s41065-020-00133-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236929PMC

TRPS1 mutation associated with trichorhinophalangeal syndrome type 1 with 15 supernumerary teeth, hypoplastic mandibular condyles with slender condylar necks and unique hair morphology.

J Dermatol 2020 Jul 29;47(7):774-778. Epub 2020 Apr 29.

Division of Orthodontics, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.

Trichorhinophalangeal syndrome type 1 (TRPS1; Online Mendelian Inheritance in Man #190350) is an autosomal dominant disorder caused by mutations in TRPS1. We report a Thai male with TRPS1 who carried a c.1842C>T (p. Read More

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http://dx.doi.org/10.1111/1346-8138.15360DOI Listing

Potential association between oral mucosal nevus and melanoma: A preliminary clinicopathologic study.

Oral Dis 2020 Mar 28. Epub 2020 Mar 28.

Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objectives: To assess potential association between oral nevi (ON) and nevus-associated melanoma (NAM), in which melanoma cells coexist with nevus cells.

Methods: A total of 74 ON patients and 7 NAM patients were retrospectively reviewed. Comparative and regression analyses of clinical and histological data were performed between two groups. Read More

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http://dx.doi.org/10.1111/odi.13335DOI Listing

Linear verrucous epidermal nevus with oral manifestations: report of two cases.

Dermatol Online J 2020 Jan 15;26(1). Epub 2020 Jan 15.

Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba.

Linear verrucous epidermal nevi (LVEN) are characterized by verrucous papules often coalescing into well-demarcated skin-colored or brown plaques following the lines of Blaschko. We present two new cases of LVEN with oral mucosa involvement and briefly discuss this very rare finding. In both cases, oral biopsies showed hyperkeratosis, acanthosis, and papillomatosis. Read More

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January 2020

Morphea with Oral Mucosa Involvement and Unilateral Nevoid Telangiectasia as an Early Presentation of Morphea: A Case Report and Review of the Literature.

J Clin Aesthet Dermatol 2020 Jan 1;13(1):38-40. Epub 2020 Jan 1.

All authors are with the Department of Dermatology and Cutaneous Surgery at the University of Miami, Miller School of Medicine in Miami, Florida.

Oral mucosal involvement in patients with morphea is quite rare. Unilateral nevoid telangiectasia is a rare vascular dermatosis characterized by unilateral telangiectasia distributed in a dermatomal pattern, especially on the upper trunk and extremities. We describe a case of a 10-year-old female patient that presents with morphea on her left chin and upper lip extending to the inner oral mucosa as well as a unilateral nevoid telangiectasia on her left cheek as an early presentation of localized scleroderma. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028378PMC
January 2020

Clinical report: one year of treatment of Proteus syndrome with miransertib (ARQ 092).

Cold Spring Harb Mol Case Stud 2020 Feb 3;6(1). Epub 2020 Feb 3.

Arqule Inc, Burlington, Massachusetts 01803, USA.

A 20-yr-old man with Proteus syndrome (PS) and somatic mosaicism of the c.49G > A p.(E17K) variant had asymmetric overgrowth of the right frontal and facial bones, asymmetric spinal overgrowth with thoracolumbar scoliosis, dilatation of the inferior vena cava, testicular cystadenoma, bilateral knee deformities, macrodactyly, and apparent intellectual disability. Read More

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http://dx.doi.org/10.1101/mcs.a004549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996520PMC
February 2020

Oral and nail pigmentations: a useful parallelism for the clinician.

J Dtsch Dermatol Ges 2020 01 17;18(1):7-14. Epub 2020 Jan 17.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Oral (OP) and nail (NP) pigmentations may occur simultaneously in physiological or pathological conditions, and may be a sign of underlying syndromic conditions that necessitate further investigation and treatment. Interestingly, the nail unit and oral cavity show a clinical parallelism that may help the clinician to conduct a correct examination and reach a prompt diagnosis. Both OP and NP can manifest clinically with focal or diffuse involvement and are due to external factors (exogenous pigmentation, drug-induced pigmentation) or endogenous factors (racial pigmentation, post-inflammatory pigmentation, nevi, genetic conditions and other disorders). Read More

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http://dx.doi.org/10.1111/ddg.14023DOI Listing
January 2020

Intracranial variant of encephalotrigeminal angiomatosis - A case report.

Indian J Dent Res 2019 Nov-Dec;30(6):978-981

Department of Oral Medicine and Radiology, Vinayaka Missions Research Foundation, Vinayaka Missions Sankarachariyar Dental College (Deemed to be University), Salem, Tamil Nadu, India.

Encephalotrigeminal Angiomatosis is a rare developmental phakomatoses characterized by the occurrence of nevus flammeus (port-wine stain) along the distribution of branches of trigeminal nerve, vascular angiomas in the eye, and leptomeningeal angiomas affecting 1 in 1,00,000 South Asian population. Herewith, such a rare case of such encephalotrigeminal angiomatosis in a 24-year-old male is described. Read More

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http://dx.doi.org/10.4103/ijdr.IJDR_517_17DOI Listing
January 2020

A Rare Case of Gorlin-Goltz Syndrome in Children.

Case Rep Dent 2019 23;2019:1608783. Epub 2019 Dec 23.

Department of Clinics, Pathology and Surgery, Federal University of Minas Gerais, Brazil.

The Gorlin-Goltz syndrome, nevoid basal cell carcinoma syndrome, or basal cell nevus syndrome is an autosomal dominant condition disorder with high variability expression. It presents a series of relevant clinical manifestations that suggest its diagnosis in cutaneous, bone, dental, soft tissue, nervous, and ocular system disorders. This condition requires a great interaction of several specialists to improve the patient's life. Read More

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http://dx.doi.org/10.1155/2019/1608783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942748PMC
December 2019

[The complex dental and oral surgical management with 8-year follow up of a Gorlin‒Goltz syndrome patient].

Orv Hetil 2020 Jan;161(2):67-74

Fogorvostudományi Kar, Arc-, Állcsont- és Szájsebészeti Tanszék, Pécsi Tudományegyetem, Klinikai Központ Pécs.

Gorlin-Goltz syndrome is an autosomal dominant hereditary disease. Its leading symptoms include keratocysts of the jaws, multiple basal cell carcinomas, skeletal abnormalities, intracranial calcifications and dyskeratosis of the soles and palms. One of the most common and often firstly discovered symptoms is the single or multiplex keratocysts of the jaws. Read More

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http://dx.doi.org/10.1556/650.2020.31566DOI Listing
January 2020

The recurrence of odontogenic keratocysts in pediatric patients is associated with clinical findings of Gorlin-Goltz Syndrome.

Med Oral Patol Oral Cir Bucal 2020 Jan 1;25(1):e56-e60. Epub 2020 Jan 1.

Post-graduation Program in Oral Pathology Federal University of Rio Grande do Norte Av. Senador Salgado Filho, 1787, Lagoa Nova Zip code: 59056-000 Natal, RN, Brazil

Background: Odontogenic keratocyst (OKC) is an odontogenic developmental cyst that presents distinct clinical behavior. This lesion has been described as dental cysts with keratinization since the 1930s, however the term OKC was established in 1956. This study aims to determine the frequency and features of OKC in children aged 0 to 14 years in an oral pathology service in Brazil. Read More

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http://dx.doi.org/10.4317/medoral.23185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982988PMC
January 2020

An extensive nevus of Ota with oro-buccal involvement: a case review and proposal of a new classification system.

Authors:
Betul Tas

G Ital Dermatol Venereol 2019 Oct;154(5):581-585

Department of Dermatology, Istanbul Bagcilar Research and Training Hospital, University of Health Sciences, Istanbul, Turkey -

Nevus of Ota (NO) also known as nevus fuscoceruleus ophthalmomaxillaris or oculodermal melanocytosis is a rare hamartoma. It is usually characterized by unilateral, patchy and speckled, blue/gray or brown macules on the forehead and periocular area. Here, we report a rare case of NO with oro-buccal involvement, which is an unusual condition. Read More

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http://dx.doi.org/10.23736/S0392-0488.17.05150-1DOI Listing
October 2019
1 Read

White sponge nevus: A condition not always clinically suspected.

J Cutan Pathol 2020 Jan 7;47(1):22-26. Epub 2019 Oct 7.

Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.

White sponge nevus (WSN) is an uncommon benign inherited disorder characterized by white and diffuse painless lesions in oral, esophageal, or genital mucosa. The lesions may develop at birth or later in childhood or adolescence, with careful clinical examination being sufficient for diagnosis in most cases. However, microscopic analysis may be necessary particularly in adults in which other whitish oral lesions may be clinically suspected. Read More

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http://dx.doi.org/10.1111/cup.13581DOI Listing
January 2020
2 Reads

Drug consumption and melanocytic nevi: correlation between oral contraceptives or hormone replacement therapy and a high melanocytic nevi count.

Eur J Cancer Prev 2020 Jul;29(4):338-341

Section of Dermatology, Department of Health Sciences, University of Florence, Ospedale Piero PalagiDepartment of Dermatology and Venereal Diseases, St. Orsola-Malpighi Hospital, Bologna, Italy.

The prolonged use of drugs such as beta-blockers, acetylsalicylic acid, omeprazole, statins, oral contraceptives and hormone replacement therapy might have some role in melanocytic nevi development and be ultimately linked to melanoma risk. Aims of the study were to evaluate a possible association between the above-mentioned drugs and features such as number and atypia of melanocytic nevi in long-term users. We retrospectively looked at pharmacological, clinical and dermoscopic records of 1321 patients that attended our unit for routine mole check between January 2013 and January 2018. Read More

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http://dx.doi.org/10.1097/CEJ.0000000000000545DOI Listing
July 2020
2 Reads

Analysis of lip pigmentations by reflectance confocal microscopy: report of two cases.

J Biol Regul Homeost Agents 2019 May-Jun;33(3 Suppl. 1):19-25

Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy.

Oral mucosa pigmentations belong to a heterogeneous variety of lesions, which are usually divided into two groups: exogenous or endogenous pigmentations. The pigmented lesions most frequently found in the oral mucosa are the amalgam tattoo, the melanotic macula and the nevus. All these lesions may affect every part of the oral mucosa, and they may represent a hard diagnostic challenge for the clinician; the clinical objective examination is not sufficient to make a correct diagnosis. Read More

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October 2019
3 Reads

The molecular-based differentiation of Heck's disease from its mimics including oral condyloma and white sponge nevus.

Ann Diagn Pathol 2019 Dec 22;43:151402. Epub 2019 Aug 22.

The Ohio State University Comprehensive Cancer Center, Columbus, OH, United States of America; Discovery Life Sciences, Powell, OH, United States of America. Electronic address:

Heck's disease (focal or multifocal epithelial hyperplasia) is a benign, rare condition of the skin and mucous membranes induced by human papillomavirus (HPV) infection. Other entities that can induce large papillomatous lesions that involve the mucous membranes and skin include condyloma acuminatum, which is sexually transmitted, and white sponge nevus, often due to a mutation of cytokeratin 4 or 13. Six cases diagnosed as either Heck's disease (n = 2) or white sponge nevus (n = 4) and 6 oral condyloma were compared on histologic grounds and analyzed in situ for HPV DNA, including HPVs 6,11, and 13, as well as cytokeratins 4 and 13. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.151402DOI Listing
December 2019
2 Reads

Association between microRNA-125b expression in formalin-fixed paraffin-embedded tumor tissues and prognosis in patients with melanoma.

Oncol Lett 2019 Aug 20;18(2):1856-1862. Epub 2019 Jun 20.

Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Melanoma is an invasive and malignant type of tumor with unsatisfactory therapeutic outcomes. The present study aimed to detect the expression levels of microRNA (miR)-125b in formalin-fixed paraffin-embedded (FFPE) melanoma tissues and the association of its expression levels with the clinical features, diagnosis and prognosis of melanoma. Expression levels of miR-125b in 29 FFPE melanoma specimens (16 primary and 13 metastatic tumors), and 16 intradermal nevus (IDN) specimens as a control, were detected by reverse transcription-quantitative PCR. Read More

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http://www.spandidos-publications.com/10.3892/ol.2019.10506
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http://dx.doi.org/10.3892/ol.2019.10506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607191PMC
August 2019
5 Reads

Multiple adenomatoid odontogenic tumors in a patient with Schimmelpenning syndrome.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Jan 14;129(1):e12-e17. Epub 2019 Jun 14.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, (UFMG), Belo Horizonte, Brazil. Electronic address:

Schimmelpenning syndrome (SS) is a congenital neurocutaneous disorder characterized by the presence of linear nevus sebaceous, ophthalmic, neurologic, skeletal, urologic, and cardiovascular alterations. Oral manifestations related to SS mainly include dental defects, papillary lesions in the oral mucosa, giant cell lesions of the jaws, and odontogenic tumors. Here, we report the first case of multiple adenomatoid odontogenic tumor observed in a patient with SS. Read More

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http://dx.doi.org/10.1016/j.oooo.2019.06.006DOI Listing
January 2020
4 Reads

Correction to: Nevus of Ota - an intraoral presentation: a case report.

J Med Case Rep 2019 Aug 7;13(1):263. Epub 2019 Aug 7.

Oral Medicine Department, Liverpool University Dental Hospital, Liverpool, UK.

In the publication of this article [1], the figures were accidentally omitted due to an error. This has now been updated in the original article within the Case presentation section. Read More

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http://dx.doi.org/10.1186/s13256-019-2194-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685178PMC
August 2019
1 Read

An unusual clinical manifestation of oral melanocytic nevus.

Gen Dent 2019 Jul-Aug;67(4):35-37

Melanocytic nevi are acquired or congenital benign neoplasms, often found in skin but rarely in the oral mucosa. This article reports an atypical case of oral hypopigmented melanocytic nevus in a 39-year-old woman referred for evaluation of a well-circumscribed papule with discrete brownish spots in the buccal mucosa. An excisional biopsy was performed, the results of which led to a clinical diagnosis of inflammatory fibrous hyperplasia. Read More

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December 2019
9 Reads

Ameloblastoma associated with syndromes: A systematic review.

J Stomatol Oral Maxillofac Surg 2020 Apr 20;121(2):146-149. Epub 2019 Jul 20.

Education Development Office, School of dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Odontogenic lesions have been described in several syndromes. Despite multiple reports of ameloblastoma's association with various syndromes, it has not been added to the diagnostic criteria for any syndrome. Thus, the aim of this systematic review was gathering such cases' data. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.07.010DOI Listing
April 2020
4 Reads

A retrospective study of malignant melanoma from a tertiary care centre in Saudi Arabia from 2004 to 2016.

Clin Transl Oncol 2020 May 29;22(5):663-669. Epub 2019 Jun 29.

Department of Pathology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

Background: Malignant melanoma is a well-known and commonly lethal tumour yet there exists scarce published information available from Saudi Arabia.

Materials And Methods: This study examined the demographic, clinical, and histopathological profile of melanoma in a sample of Saudi patients over a period of 13 years. Medical records of 98 patients from 2004 to 2016 were retrieved from the Department of Pathology and Laboratory Medicine at King Faisal Specialist Hospital (KFSH), Riyadh, Saudi Arabia. Read More

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http://dx.doi.org/10.1007/s12094-019-02169-wDOI Listing
May 2020
8 Reads
2.440 Impact Factor

Odontogenic keratocysts located in the buccal mucosa: A description of two cases and review of the literature.

SAGE Open Med Case Rep 2019 19;7:2050313X19849828. Epub 2019 May 19.

Department of Pathology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Odontogenic keratocysts make up 4%-12% of all odontogenic cysts. Most cysts are sporadic but sometimes they arise in the context of basal cell nevus syndrome (Gorlin syndrome). Most odontogenic keratocysts arise in the posterior region of the mandible, but they can occur anywhere in the jaw. Read More

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http://dx.doi.org/10.1177/2050313X19849828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537049PMC
May 2019
8 Reads

Nevus of Ota - an intraoral presentation: a case report.

J Med Case Rep 2019 Jun 7;13(1):174. Epub 2019 Jun 7.

Oral Medicine Department, Liverpool University Dental Hospital, Liverpool, UK.

Background: Nevus of Ota or "oculodermal melanocytosis" is a rare congenital hamartoma of dermal melanocytes causing a blue-gray hyperpigmentation of the eye and surrounding structures. The condition, originally described by Ota and Tanino in 1939, mainly affects the ophthalmic and maxillary divisions of the trigeminal nerve. We describe the first reported case of unilateral oculodermal melanocytosis in a Caucasian woman with oral buccal mucosal involvement. Read More

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http://dx.doi.org/10.1186/s13256-019-2101-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554954PMC
June 2019
16 Reads

PTCH1 alterations are frequent but other genetic alterations are rare in sporadic odontogenic keratocysts.

Oral Dis 2019 Sep 4;25(6):1600-1607. Epub 2019 Jun 4.

Department of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing, China.

Objective: Odontogenic keratocysts (OKCs) are benign jaw lesions with high growth potential and propensity for recurrence. Our previous study revealed that PTCH1 mutations, which were frequently detected in sporadic OKCs, might be underestimated due to the masking effect of the stromal components within the tested tissues. We aimed to confirm these results in larger scale and further present the unbiased view of the genomic basis of sporadic OKCs except PTCH1. Read More

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http://dx.doi.org/10.1111/odi.13135DOI Listing
September 2019
14 Reads

Clinical and histopathological study of the oral multifocal melanoacanthoma: A case report.

J Clin Exp Dent 2019 Apr 1;11(4):e391-e394. Epub 2019 Apr 1.

MSc, PhD. Professor Department of Dentistry, State University of Paraíba, Campina Grande, Paraíba, Brazil.

Melanoacanthoma is a blackened mucocutaneous lesion, mainly affecting individuals with dark skin and exhibiting rapid development. Differential diagnosis includes nevus, amalgam tattoo and melanoma. This article reports a case of a 53-year-old white woman, who exhibited multiple blackened lesions on the gingiva and upper lip. Read More

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http://dx.doi.org/10.4317/jced.55344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522109PMC
April 2019
8 Reads

Genetic and developmental disorders of the oral mucosa: Epidemiology; molecular mechanisms; diagnostic criteria; management.

Periodontol 2000 2019 06;80(1):12-27

WHO Collaboration Centre for Epidemiology and Community Dentistry, University of Milan, Milan, Italy.

A large number of disorders may affect the oral cavity, including genetic diseases, infections, cancers, blood diseases, skin diseases, endocrine and metabolic disorders, autoimmune and rheumatologic diseases, local lesions, to name a few. Oral mucosa shows a considerable variation in its normal structure and a wide range of conditions may affect it. Such conditions are often harmless or minor and could be primary or secondary to systemic disease. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/prd.12261
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http://dx.doi.org/10.1111/prd.12261DOI Listing
June 2019
39 Reads

Meningioma associated with Gorlin-Goltz syndrome and a short review of literature.

Neurol India 2019 Mar-Apr;67(2):595-598

Department of Pathology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

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http://dx.doi.org/10.4103/0028-3886.257991DOI Listing
December 2019
4 Reads

Identification of NSDHL mutations associated with CHILD syndrome in oral verruciform xanthoma.

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Jul 23;128(1):60-69. Epub 2019 Feb 23.

Departments of Oral and Craniofacial Health Sciences and Dental Ecology, UNC School of Dentistry, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, UNC School of Medicine, Chapel Hill, NC, USA. Electronic address:

Objective: The aim of this study was to perform a systematic analysis of the nicotinamide adenine dinucleotide phosphate (NAD[P])-dependent steroid dehydrogenase-like (NSDHL) gene in cases of oral verruciform xanthoma (VX) and to test for the presence of mutations associated with congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD) syndrome.

Study Design: DNA was extracted from archived paraffin-embedded tissue of oral VX and control cases. Polymerase chain reaction (PCR) was then used to screen exons 4 and 6 of the NSDHL gene for the presence of 4 known germline mutations associated with CHILD syndrome and 1 somatic mutation previously identified in VX lesions with no known association with CHILD syndrome. Read More

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http://dx.doi.org/10.1016/j.oooo.2019.02.015DOI Listing
July 2019
10 Reads

Efficacy and safety of sirolimus in the treatment of blue rubber bleb naevus syndrome in paediatric patients.

Clin Exp Dermatol 2020 Jan 12;45(1):79-85. Epub 2019 Jun 12.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University (National Center for Children's Health, China), Beijing, China.

Blue rubber bleb naevus syndrome (BRBNS) is an extremely rare venous malformation that often manifests as multiple haemangioma-like lesions in the skin and gastrointestinal tract. The drug sirolimus plays a key role in the signalling pathway of angiogenesis and subsequent development of BRBNS and its use has been described in several case reports. We present a case series of four patients with BRBNS who exhibited good treatment response to sirolimus. Read More

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http://dx.doi.org/10.1111/ced.14003DOI Listing
January 2020
2 Reads

An enigma of Gorlin-Goltz syndrome: Two cases reported in mother and daughter.

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):115-121

Department of Oral and Maxillofacial Surgery, Haldia Institute of Dental Sciences and Research, West Bengal University of Health Sciences, Haldia, West Bengal, India.

Gorlin-Goltz syndrome (GGS) also known as the nevoid basal cell carcinoma syndrome or the nevus-Bifid rib syndrome is an inherited autosomal dominant syndrome. It is caused by genetic alteration produced by a mutation in the "patched" tumor suppressor gene. This rare syndrome is characterized by basal cell carcinoma of skin, multiple odontogenic keratocyst and bifid ribs along with other features such as hypertelorism, sex organ abnormalities, palmar and/or plantar pits and calcification of falx cerebri. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_160_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421933PMC
February 2019
8 Reads

A novel mutation in basal cell nevus syndrome with rare craniofacial features.

Hum Genome Var 2019 2;6:16. Epub 2019 Apr 2.

1Department of Orthodontics and Dentofacial Orthopedics, Osaka University Graduate School of Dentistry, Suita, Japan.

Basal cell nevus syndrome (BCNS) is a rare, multisystem, autosomal dominant disorder that is characterized by various phenotypes, including multiple basal cell carcinomas of the skin, odontogenic keratocysts of the jaws, and occasionally cleft lip and/or palate. In this report, we describe a 6-year-old Japanese girl with a novel heterozygous nonsense mutation in who exhibited rare craniofacial phenotypes, such as oligodontia and a short-tooth root. Read More

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http://dx.doi.org/10.1038/s41439-019-0047-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445144PMC
April 2019
13 Reads

Gorlin-Goltz Syndrome: A Case Report and Literature Review.

Cureus 2019 Jan 8;11(1):e3849. Epub 2019 Jan 8.

Oral and Maxillofacial Surgery, King Saud University, Riyadh, SAU.

Gorlin-Goltz syndrome (GGS) is an infrequent multisystemic disease with an autosomal dominant inherited disorder characterized by the presence of multiple keratocystic odontogenic tumors (KCOT) in the jaws, multiple basal cell nevi carcinomas, and skeletal abnormalities. Early diagnosis of Gorlin-Goltz syndrome is essential as it may progress to aggressive basal cell carcinomas and neoplasias. Gorlin-Goltz syndrome has rarely been reported in Saudi Arabia. Read More

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http://dx.doi.org/10.7759/cureus.3849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411325PMC
January 2019
9 Reads

Oral compound nevus: an unusual presentation.

Indian J Dermatol Venereol Leprol 2020 May-Jun;86(3):284-285

Department of Oral Medicine and Radiology, SVS Institute of Dental Sciences, Mahaboobnagar, Telangana, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_676_18DOI Listing
March 2019
5 Reads

Invasive melanoma in a 5-year-old Canadian patient: A case report.

SAGE Open Med Case Rep 2019 18;7:2050313X19829630. Epub 2019 Feb 18.

Division of Dermatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

Atypical Spitzoid lesions pose a distinct challenge in classification as they may comprise a mixture of both classic benign nevus and cutaneous melanoma characteristics. Immunostaining and molecular analysis, such as comparative genomic hybridization, can assist in narrowing the differential diagnosis. We present a case of a 5-year-old male with an atypical Spitzoid lesion on his back. Read More

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http://dx.doi.org/10.1177/2050313X19829630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381421PMC
February 2019
11 Reads

Multidisciplinary oral rehabilitation of an adolescent suffering from juvenile Gorlin-Goltz syndrome - a case report.

Head Face Med 2019 Feb 8;15(1). Epub 2019 Feb 8.

Department of Oral and Maxillofacial Surgery, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Fetscherstr. 74, D-01307, Dresden, Germany.

Background: The Gorlin-Goltz syndrome is an autosomal dominant disorder characterized by keratocystic odontogenic tumors in the jaws, multiple basal cell carcinomas and skeletal abnormities. Frequently, the manifestation of the syndrome occurs in the adolescent years.

Case Presentation: An 11-year-old boy was referred to our clinic due to the persistence of the lower deciduous molars. Read More

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http://dx.doi.org/10.1186/s13005-019-0189-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367745PMC
February 2019
17 Reads

Black and Brown Oro-facial Mucocutaneous Neoplasms.

Authors:
Easwar Natarajan

Head Neck Pathol 2019 Mar 29;13(1):56-70. Epub 2019 Jan 29.

Section of Oral and Maxillofacial Pathology, University of Connecticut Health Center, 263 Farmington Ave, MC-0925, Farmington, CT, 06030, USA.

Black and brown-colored mucocutaneous lesions present a differential diagnostic challenge, with malignant melanoma being the primary clinical concern. The vast majority of pigmented lesions in the head and neck region are the result of benign, reactive factors such as post-inflammatory melanosis. However, it is not uncommon to discover a range of muco-cutaneous black and brown neoplasms in the oro-facial area. Read More

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http://dx.doi.org/10.1007/s12105-019-01008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406009PMC
March 2019
14 Reads

Frictional Keratosis, Contact Keratosis and Smokeless Tobacco Keratosis: Features of Reactive White Lesions of the Oral Mucosa.

Authors:
Susan Müller

Head Neck Pathol 2019 Mar 22;13(1):16-24. Epub 2019 Jan 22.

Atlanta Oral Pathology, Emory Decatur Hospital, Emory University School of Medicine, 2701 N. Decatur Road, Decatur, GA, 30033, USA.

White lesions of the oral cavity are quite common and can have a variety of etiologies, both benign and malignant. Although the vast majority of publications focus on leukoplakia and other potentially malignant lesions, most oral lesions that appear white are benign. This review will focus exclusively on reactive white oral lesions. Read More

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http://dx.doi.org/10.1007/s12105-018-0986-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405791PMC
March 2019
10 Reads

Effect of the sonic hedgehog inhibitor GDC-0449 on an in vitro isogenic cellular model simulating odontogenic keratocysts.

Int J Oral Sci 2019 01 5;11(1). Epub 2019 Jan 5.

Department of Oral Pathology, Peking University School and Hospital of Stomatology, 22 South Zhongguancun Avenue, Haidian District, Beijing, China.

Odontogenic keratocysts (OKCs) are common cystic lesions of odontogenic epithelial origin that can occur sporadically or in association with naevoid basal cell carcinoma syndrome (NBCCS). OKCs are locally aggressive, cause marked destruction of the jaw bones and have a propensity to recur. PTCH1 mutations (at ∼80%) are frequently detected in the epithelia of both NBCCS-related and sporadic OKCs, suggesting that PTCH1 inactivation might constitutively activate sonic hedgehog (SHH) signalling and play a major role in disease pathogenesis. Read More

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http://dx.doi.org/10.1038/s41368-018-0034-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320367PMC
January 2019
13 Reads
2.029 Impact Factor

Corneal dysplastic melanosis associated with recurrent corneal erosions: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13367

Department of Ophthalmology, Seoul National University College of Medicine.

Rationale: Pigmented lesions of conjunctiva and cornea can be observed in various conditions, from the benign nevus to malignant melanoma. Pigmented acquired melanosis (PAM) is one of them, which is a neoplastic proliferation with malignant transformation potential of melanocytes. However, to our knowledge, there has been no report as to a disturbance of corneal barrier function caused by PAM. Read More

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http://dx.doi.org/10.1097/MD.0000000000013367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319972PMC
December 2018
35 Reads

Cover Image: Naevus sebaceus affected by overgrowth of Malassezia globosa.

Br J Dermatol 2018 12;179(6):1432-1433

Department of Dermatovenereology, West China Hospital, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.

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http://dx.doi.org/10.1111/bjd.17155DOI Listing
December 2018
7 Reads

An Update of Gorlin-Goltz Syndrome.

Prim Dent J 2018 Sep;7(3):38-41

Gorlin-Goltz syndrome encompasses a variety of clinical signs and symptoms including important oral manifestations which general dental practitioners should be aware of. In light of the risk of malignancy it is important to be aware of this syndrome and recognise the need for early referral for multidisciplinary management. This paper aims to discuss Gorlin-Goltz syndrome, the pathophysiology of the condition and address the wide range of clinical manifestations. Read More

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September 2018
24 Reads

A Comparative Evaluation of Surgical, Electrosurgery and Diode Laser in the Management of Maxillofacial Nevus.

J Maxillofac Oral Surg 2018 Dec 6;17(4):547-556. Epub 2018 Feb 6.

2Department of Oral and Maxillofacial Surgery, A.C.P.M. Dental College and Hospital, Dhule, India.

Purpose: To compare the post-operative wound healing of patients treated for excision of the nevus/mole from maxillofacial region with surgical, electrosurgery and diode laser.

Materials And Methods: Forty-five clinically confirmed cases of benign nevus were included in the study and randomly divided into three groups according to the technique used for excision, i.e. Read More

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http://link.springer.com/10.1007/s12663-018-1081-8
Publisher Site
http://dx.doi.org/10.1007/s12663-018-1081-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181846PMC
December 2018
7 Reads

Non syndromic synchronous multiple odontogenic keratocysts in a western Indian population: A series of four cases.

J Clin Exp Dent 2018 Aug 1;10(8):e831-e836. Epub 2018 Aug 1.

MDS, Assistant Professor, Department of Oral Pathology, RUHS College of Dental Sciences, Jaipur, Rajasthan, India.

Odontogenic keratocysts (OKCs) are developmental odontogenic cysts affecting the maxillofacial region and their association with a syndrome especially Naevoid basal cell carcinoma syndrome (NBCCS) is a common occurrence in comparison to non syndromic multiple OKCs. In a first, we present a series of four non syndromic cases with multiple OKCs in western Indian population. The presence of multiple OKC in our present case series may be because of the multifocal nature of the lesion rather than its association with any syndrome. Read More

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http://dx.doi.org/10.4317/jced.54616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174012PMC
August 2018
11 Reads

Dermatological manifestations in cardiofaciocutaneous syndrome: a prospective multicentric study of 45 mutation-positive patients.

Br J Dermatol 2019 01 30;180(1):172-180. Epub 2018 Sep 30.

Department of Clinical Genetics, Arnaud de Villeneuve Hospital, University of Montpellier, Montpellier, France.

Background: Data on dermatological manifestations of cardiofaciocutaneous syndrome (CFCS) remain heterogeneous and almost without expert dermatological classification.

Objectives: To describe the dermatological manifestations of CFCS; to compare them with the literature findings; to assess those discriminating CFCS from other RASopathies, including Noonan syndrome (NS) and Costello syndrome (CS); and to test for dermatological phenotype-genotype correlations.

Methods: We performed a 4-year, large, prospective, multicentric, collaborative dermatological and genetic study. Read More

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http://doi.wiley.com/10.1111/bjd.17077
Publisher Site
http://dx.doi.org/10.1111/bjd.17077DOI Listing
January 2019
9 Reads

Surgery for Blue Rubber Bleb Nevus Syndrome-a Case Report.

Indian J Surg 2018 Jun 19;80(3):272-274. Epub 2017 Dec 19.

Department of General Surgery ,TMCH, Thanjavur, India.

Blue rubber bleb nevus syndrome (BRBNS) is a rare disease characterised by multiple venous malformations and haemangioma in the skin and visceral organs. The lesion often involves the cutaneous and gastrointestinal tract. Most common visceral organ affected is the GIT. Read More

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http://dx.doi.org/10.1007/s12262-017-1715-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014949PMC
June 2018
61 Reads

Pigmented lesions of the oral mucosa: A cross-sectional study of 458 histopathological specimens.

Oral Dis 2018 Nov 10;24(8):1484-1491. Epub 2018 Jul 10.

Department of Oral Pathology and Surgery, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Objectives: To evaluate clinical, demographic, and histopathological characteristics of pigmented lesions of the oral mucosa.

Materials And Methods: A cross-sectional study was conducted over a 64-year period. Information was collected from medical charts, and all archived histopathological specimens with diagnoses of any pigmented lesion were retrieved. Read More

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http://dx.doi.org/10.1111/odi.12924DOI Listing
November 2018
11 Reads

A call to study orphan diseases.

Authors:
Faizan Alawi

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 08 22;126(2):95-97. Epub 2018 May 22.

Associate Professor of Pathology, University of Pennsylvania, School of Dental Medicine, 240 South 40th Street, Room 328B, Philadelphia, PA 19104, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S22124403183093
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http://dx.doi.org/10.1016/j.oooo.2018.05.003DOI Listing
August 2018
6 Reads