Search Our Scientific Publications & Authors

J Evid Based Dent Pract 2022 06 16;22(2):101717. Epub 2022 Mar 16.

Article Title And Bibliographic Information: González-Moles MÁ, Ramos-García P, Warnakulasuriya S. An appraisal of highest quality studies reporting malignant transformation of oral lichen planus based on a systematic review. Oral Dis. Read More

Case Rep Dent 2022 2;2022:7890338. Epub 2022 Jun 2.

Department of Oral and Maxillofacial Pathology, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar, Odisha, India.

Hamartomas are tumor-like deformities typified by cellular propagation indigenous to the original site, although they display growth arrest without the possibility for further growth. Various hamartomatous oral lesions include hemangiomas, lymphangiomas, nevi, odontomas, Cherubism, etc. Lymphangiomas are benign, developmental hamartomatous entities typified by abnormal proliferation of lymphatic vessels. Read More

J Oral Pathol Med 2022 Jun 4. Epub 2022 Jun 4.

Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.

Background: Odontogenic keratocyst (OKC) is characterized by local aggressive behavior and a high recurrence rate, as well as the potential to develop in association with the Basal Cell Nevus Syndrome (BCNS). The aim of this study was to decode the gene expression program accompanying OKC phenotype.

Methods: 150-bp paired-end RNA-sequencing was applied on 6 sporadic and 6 BSCN-associated whole-tissue OKC samples in comparison to 6 dental follicles, coupled to bioinformatics and complemented by immunohistochemistry. Read More

J Oral Maxillofac Res 2022 Jan-Mar;13(1):e5. Epub 2022 Mar 31.

Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of AthensGreece.

Background: Oral melanocytic nevi are relatively rare in comparison to their cutaneous counterparts. The aim of this manuscript is to present a case of acquired compound oral melanocytic nevi on the hard palatal mucosa of a child.

Methods: A 5-year-old female girl was referred for evaluation of a pigmented lesion on the hard palate. Read More

J Invest Dermatol 2022 May 12. Epub 2022 May 12.

Institut Genetics, Reproduction & Development (iGReD), CNRS, Inserm, University of Clermont-Auvergne, France. Electronic address:

Carney complex is a rare familial multineoplastic syndrome predisposing to endocrine and nonendocrine tumors due to inactivating mutations of PRKAR1A, leading to perturbations of the cAMP‒protein kinase A signaling pathway. Skin lesions are the most common manifestation of Carney complex, including lentigines, blue nevi, and cutaneous myxomas in unusual locations such as oral and genital mucosa. Unlike endocrine disorders, the pathogenesis of skin lesions remains unexplained. Read More

J Clin Med 2022 Apr 29;11(9). Epub 2022 Apr 29.

Department of Maxillofacial Surgery, Medical University of Lodz, 113 S. Zeromski Street, 90-549 Lodz, Poland.

The differential diagnosis of benign nevi (BN), dysplastic nevi (DN), and melanomas (MM) represents a considerable clinical problem. These lesions are similar in clinical examination but have different prognoses and therapeutic management techniques. A texture analysis (TA) is a mathematical and statistical analysis of pixel patterns of a digital image. Read More

Am J Dermatopathol 2022 May 3. Epub 2022 May 3.

Department of Stomatology, Dental School, University of Sao Paulo, Sao Paulo, Brazil; and.

Abstract: Oral pigmentations are a heterogeneous group and can be the result of physiological activity of oral mucosal melanocytes, secondary to exogenous causes, associated with systemic or local diseases, or due to proliferative activity of melanocytes. Their diagnosis is critical because these lesions can be markers of internal diseases or, in the case of melanocytic proliferative processes, they may represent a malignant neoplasm. In the past decade, the use of reflectance confocal microscopy, a noninvasive imaging tool, has aided the analysis of such lesions, but the establishment of firm criteria in their evaluation is still lacking. Read More

Int J Oral Maxillofac Surg 2022 Apr 15. Epub 2022 Apr 15.

Department of Biochemistry, Tokyo Dental College, Chiyoda-ku, Tokyo, Japan. Electronic address:

Gorlin syndrome is a rare autosomal dominant disease caused by mutations in the PTCH1, PTCH2, and SUFU genes. Each symptom of the disease has a different time point of onset, which makes early diagnosis based solely on symptoms challenging. In this study, a gene panel was developed to overcome the challenges in the diagnosis of Gorlin syndrome and allow diagnosis using a single test. Read More

Oral Maxillofac Surg Clin North Am 2022 May 12;34(2):251-262. Epub 2022 Apr 12.

Division of Surgical Oncology, University of Nebraska Medical Center, 986345 Nebraska Medical Center, Omaha, NE 68198-6345, USA.

Surgical management of head and neck melanoma starts from the primary biopsy of the cutaneous site by a narrow excision with a 1 to 3 mm margins. The margin should include the whole breadth and sufficient depth of the lesion. The key is not to transect the lesion. Read More

J Drugs Dermatol 2022 Apr;21(4):425-426

Becker nevus (BN) is a benign cutaneous smooth muscle hamartoma that presents with a hyperpigmented patch or plaque with or without hypertrichosis.1 BN may be associated with ipsilateral breast hypoplasia or other musculoskeletal abnormalities, an association which has been termed Becker nevus syndrome (BNS). Read More

J Pediatr Hematol Oncol 2022 05 1;44(4):e869-e871. Epub 2022 Mar 1.

Department of Pediatrics, Osaka Medical and Pharmaceutical University, Osaka.

We present a case of Gorlin-Goltz syndrome (GGS) in a patient who developed medulloblastoma, osteosarcoma, myelodysplastic syndrome, basal cell carcinoma, and odontogenic keratocyst by the age of 19 years. He had no known family history and no characteristic physical features of GGS. A frameshift mutation in the PTCH1 gene was found in the oral mucosa as a low-frequency mosaicism, basal cell carcinoma, and normal skin by whole exome sequencing of cancer susceptibility genes. Read More

Case Rep Dermatol Med 2022 15;2022:6329334. Epub 2022 Feb 15.

Stomatology Department, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.

Oral common blue nevus is an asymptomatic, benign, rare, pigmented lesion and sometimes clinically indistinguishable from other pigmented lesions such as the cellular blue nevus or early-stage malignant melanoma. Since it shows clinical similarities with a malignant lesion and with cellular blue nevus that can itself suffer malignant transformation, the decisive diagnosis is crucial for adequate treatment, follow-up, and prognosis. Diagnosis confirmation is given by histological analysis, the reason why most oral pigmented lesions are excised. Read More

J Dermatol 2022 06 16;49(6):e187-e188. Epub 2022 Feb 16.

Department of Dermatology, Nara Medical University School of Medicine, Nara, Japan.

Zhonghua Kou Qiang Yi Xue Za Zhi 2022 Feb;57(2):149-154

Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

To detect the SMO mutations in odontogenic keratocyst (OKC) and to explore the mechanism behind. Patients with OKC who received treatment in the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology,Peking University, from September 2012 to June 2017 were enrolled. OKC samples from 10 patients diagnosed as naevoid basal cell carcinoma syndrome (NBCCS)-related OKC (4 females and 6 males) and 20 patients diagnosed as sporadic OKC (7 females and 13 males) were collected. Read More

Clin Case Rep 2022 Jan 18;10(1):e05311. Epub 2022 Jan 18.

Dermatology Department Hedi Chaker University Hospital Sfax Tunisia.

Compound blue nevus had clinical and histological similarities with other heavily pigmented melanocytic tumor, like the pigmented epithelioid melanocytoma. Distinctive genomic aberrations have allowed differentiating it. The defining characteristic of blue nevi family is the presence of activating mutations in the G protein α-subunits, GNAQ and GNA11. Read More

Oral Oncol 2022 02 7;125:105707. Epub 2022 Jan 7.

Cancer and Translational Research Lab, Dr. D.Y. Patil Biotechnology & Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra 411033, India.

Transl Pediatr 2021 Nov;10(11):2960-2971

Department of Gastroenterology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Background: Blue rubber bleb nevus syndrome is a rare congenital disease characterized by multiple venous malformations in skin and gastrointestinal tract, not all patients have typical cutaneous lesions, refractory anemia may be the only clinical symptom, it is easy to miss diagnosis.

Methods: A retrospective single center study was conducted on 8 patients with blue rubber bleb nevus syndrome from 2009 to 2021. Data were analyzed including clinical feature, diagnostic workup and results, gene detection, treatment and follow-up. Read More

In Vivo 2022 Jan-Feb;36(1):274-293

Institute of Human Genetics, Otto-von-Guericke University, Magdeburg, Germany.

Background/aim: The aim of this study was to present the long-term course of a patient with nevus sebaceous syndrome (NSS). Recent genetic studies place the syndrome in the emerging group of so-called RASopathies. The focus of the report is on surgical treatment and morphological and genetic findings of the face and oral cavity. Read More

Melanoma Res 2022 02;32(1):59-62

Department of Dermatology, Ajou University School of Medicine.

Ponatinib, an oral third-generation tyrosine kinase inhibitor, is indicated for the treatment of imatinib-resistant leukemia. We experienced a case of ponatinib-induced eruptive nevi, and the biologic effects of ponatinib on melanocytes were investigated. Treatment with ponatinib significantly increased the proliferation of normal human melanocyte or melanoma cells through the upregulation of the extracellular signal-regulated kinase and protein kinase B signaling pathways. Read More

J UOEH 2021 ;43(4):421-426

Department of Dentistry and Oral Surgery, University Hospital of Occupational and Environmental Health, Japan.

White spongiform nevus is an autosomal dominant inherited disorder first reported by Cannon in 1935. It is a rare disease in which the oral mucosa thickens into an edematous and spongy state and is often accompanied by difficult to recognize subjective symptoms. We report a case of multiple non-hereditary white cavernous nevi in the oral mucosa. Read More

Int J Mol Sci 2021 Nov 12;22(22). Epub 2021 Nov 12.

Department of Dermatology and Venereology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.

Maintaining a balanced state in remodeling the extracellular matrix is crucial for tissue homeostasis, and this process is altered during skin cancer progression. In melanoma, several proteolytic enzymes are expressed in a time and compartmentalized manner to support tumor progression by generating a permissive environment. One of these proteases is the matrix metalloproteinase 14 (MMP14). Read More

J Cutan Med Surg 2022 Mar-Apr;26(2):149-155. Epub 2021 Nov 18.

3158 Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.

Background: Neonatal curettage of large to giant congenital melanocytic nevi (L-GCMN) is a simple, minimally invasive procedure typically performed within the first 2 weeks of life.

Objectives: To retrospectively review our experience with serial curettage of L-GCMN in the neonatal period performed under local anesthesia and their long-term outcomes.

Methods: Curettage was performed by a single pediatric dermatologist on nine neonates with L-GCMN under local anesthetic and with oral analgesia between 2002 and 2016 in Red Deer, Alberta, Canada. Read More

Gerodontology 2021 Dec;38(4):445-448

Laboratory of Morphology and Experimental Pathology, Institute of Technology and Research, Tiradentes University (UNIT), Aracaju, Brazil.

Objective: To report a rare case of intraoral extensive blue nevus in an elder patient.

Background: Oral blue nevi is a well-recognised skin melanocytic neoplasm that rarely occurs in the oral cavity and may mimic melanoma in the early stages.

Methods: An incisional biopsy was performed, and the diagnosis was blue nevus. Read More

Dermatol Ther 2022 01 18;35(1):e15201. Epub 2021 Nov 18.

Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Eur J Dent 2021 Nov 9. Epub 2021 Nov 9.

Department of Oral Diagnostic Sciences, College of Dental Medicine, Rangsit University, Pathumtani, Thailand.

Objectives:  The aim of this study was to determine the prevalence and clinical features of pigmented oral lesions from Thailand.

Materials And Methods:  Biopsy records of the Department of Oral Pathology, Chulalongkorn University, Department of Oral Diagnosis, KhonKaen University, Department of Oral Biology and Oral Diagnostic Sciences, Chiangmai University, Department of Stomatology, Prince of Songkla University, and Rangsit University were reviewed for oral pigmented lesions diagnosed during 1999 to 2019. Demographic data were culled from the biopsy records. Read More

Cancer Prev Res (Phila) 2022 02 8;15(2):129-138. Epub 2021 Nov 8.

From the Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.

DNA damage plays a role in ultraviolet (UV)-induced melanoma. We previously showed that aspirin (ASA) can suppress prostaglandin-E (PGE) and protect melanocytes from UV-induced DNA damage in mice, and suggested that taking ASA before acute sun exposure may reduce melanoma risk. We conducted a prospective randomized placebo-controlled trial to determine if orally administered ASA could suppress PGE in plasma and nevi and protect nevi from UV-induced DNA damage. Read More

J Oral Maxillofac Pathol 2021 May-Aug;25(2):374. Epub 2021 Aug 31.

Department of Pedodontics and Preventive Dentistry, SGT University, Gurugram, Haryana, India.

Plexiform neurofibroma (PNF) is a rare form of neurofibromatosis type 1 which is rarely seen isolated. This generally spreads along the peripheral nerve and may affect some nervous rami. This is a poorly circumscribed and locally invasive tumor. Read More

Orphanet J Rare Dis 2021 10 21;16(1):443. Epub 2021 Oct 21.

Department of Biochemistry, Tokyo Dental College, 2-9-18, Kanda Misakichou, Chiyoda, Tokyo, 101-0061, Japan.

Background: Basal cell carcinoma (BCC) is the most commonly occurring neoplasm in patients with Gorlin syndrome. It is widely accepted that multiple basal cell carcinomas simultaneously develop in middle-aged patients with this syndrome. However, the presence of driver genes other than the PTCH1 in Gorlin syndrome has not been explored. Read More

Bone Rep 2021 Dec 1;15:101138. Epub 2021 Oct 1.

Department of Pediatric Endocrinology, Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, Oxford Road, Manchester M13 9WL, UK.

Cutaneous skeletal hypophosphatemia syndrome (CSHS) is a rare disorder caused by somatic mosaicism for the gain of function mutations . Affected patients have segmental epidermal nevi, dysplastic cortical bony lesions, and fibroblast growth factor-23 (FGF23)-mediated hypophosphatemic rickets. Herein, we describe a case of an Emirati girl with CSHS, whose hypophosphatemic rickets and osteomalcic pseudofractures and dysplastic bony lesions failed to recover due to poor adherence to treatment with oral phosphate supplements and alfacalcidol (conventional treatment). Read More