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Front Immunol 2020 18;11:1065. Epub 2020 Jun 18.

Université de Strasbourg, INSERM UMR_S 1109 "Molecular ImmunoRheumatology", Strasbourg, France.

The field of primary immunodeficiencies (PIDs) is rapidly evolving. Indeed, the number of described diseases is constantly increasing thanks to the rapid identification of novel genetic defects by next-generation sequencing. PIDs are now rather referred to as "inborn errors of immunity" due to the association between a wide range of immune dysregulation-related clinical features and the "prototypic" increased infection susceptibility. Read More

Spec Care Dentist 2020 Jul 3. Epub 2020 Jul 3.

Department of Dental Materials and Prosthodontics, School of Dentistry of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.

Jeune syndrome (JS) is a rare disease, with systemic manifestations, such as renal and hepatic insufficiency, retinal pigmentation, and respiratory insufficiency. Etiological factors have not been completely elucidated, but the molecular biology has contributed to the diagnosis and understanding of JS with DNA sequencing, showing the association among polymorphisms in different genes DYNC2H1 (MIM 603297) and TCTEX1D2 (MIM617353), which are the main genes associated with JS. There are a few reports on buccal findings in these patients; here, we present dental anomalies and clinical oral findings in a patient with JS, focusing on a multidisciplinary approach for rehabilitation. Read More

Lupus Sci Med 2020 Jul;7(1)

Department of Clinical Immunology and Internal Medicine, National Reference Center for autoimmune diseases (RESO), Strasbourg University Hospital, Strasbourg, France.

Objective: Systemic lupus is a chronic autoimmune disease characterised by its phenotypic heterogeneity. Neutropaenia is a frequent event in SLE occurring in 20%-40% of patients depending on the threshold value of neutrophil count. On a daily basis, the management of neutropaenia in SLE is difficult with several possible causes. Read More

Br J Biomed Sci 2020 Jul 2:1-5. Epub 2020 Jul 2.

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University Fayoum, Egypt.

Background: Systemic Lupus Erythematous (SLE) is a chronic systemic autoimmune disorder whose diagnosis depends on combination of multiple factors. Circulating lncRNAs could serve as diagnostic non-invasive biomarkers for SLE. We hypothesised that serum FAS-AS1 and PVT1 are new biomarkers for SLE that relate to clinical features and laboratory markers. Read More

Oral Dis 2020 Jul 2. Epub 2020 Jul 2.

Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Milan, Italy.

The novel coronavirus disease 2019 (COVID-19) had caused major disruptions in medical and dental care across the world, affecting secondary care services that had to rapidly adapt to new circumstances. Postponed and delayed oral medicine (OM) care, deferring non-urgent follow-ups in case of patients because of COVID-19 crisis, and limited access to health care, may have lead serious consequences fororal and systemic health (Arduino et al, 2020; Jones et al, 2020). Deferred diagnosis of a malignant conditionwhen suspected or even dysplasia in oralleucoplakia cases vastly implies the clinical outcome, influencing treatment and prognosis, subsequently(Meng et al, 2020). Read More

Am J Ophthalmol Case Rep 2020 Sep 22;19:100793. Epub 2020 Jun 22.

Department of Ophthalmology, Brooke Army Medical Center, San Antonio, TX, USA.

Purpose: To report a rare case of Vogt-Koyanagi-Harada disease likely secondary to post-infectious autoimmune response in a 14-year-old Hispanic female.

Observations: On presentation, visual acuity was 20/400 in the right eye and 20/20 in the left eye. The patient also had bilateral hyperemia, subretinal fluid, and vitreous cell graded at 1+. Read More

Ter Arkh 2019 May 15;91(5):111-119. Epub 2019 May 15.

A.N. Ryzhikh State Scientific Centre of Coloproctology.

Behçet's disease (BD) is a systemic vasculitis of unknown origin, characterized by recurrences of the ulcerative process in the oral cavity and on the genitals, inflammatory damage of the eyes, joints, vessels and other organs. The severity and prognosis of BD determines organ pathology. Intestinal manifestations of BD (intestinal BD) are the least studied. Read More

Front Immunol 2020 3;11:1108. Epub 2020 Jun 3.

Department for Rheumatology, Immunology and Allergology, Inselspital-University Hospital of Bern, Bern, Switzerland.

Rheumatoid arthritis (RA) is a systemic immune mediated inflammatory disease of unknown origin, which is predominantly affecting the joints. Antibodies against citrullinated peptides are a rather specific immunological hallmark of this heterogeneous entity. Furthermore, certain sequences of the third hypervariable region of human leukocyte antigen (HLA)-DR class II major histocompatibility (MHC) molecules, the so called "shared epitope" sequences, appear to promote autoantibody positive types of RA. Read More

Clin Exp Immunol 2020 Jun 24. Epub 2020 Jun 24.

Queen Mary University of London, Centre for Oral Immunobiology and Regenerative Medicine, Barts and The London School of Medicine and Dentistry, Blizard Building, 4 Newark Street, Whitechapel London, E1 2AT, UK.

Behçet's disease (BD) is a vasculitis of unknown aetiology typified by chronic recurrent oral ulcers and systemic inflammatory manifestations. Neutrophils, and specifically their protease neutrophil elastase (NE), have been implicated in its pathology. Although NE is an effective antimicrobial, excessive NE can damage host tissue. Read More

Cancers (Basel) 2020 Jun 19;12(6). Epub 2020 Jun 19.

Unit of Dentistry, Bambino Gesù Children's Hospital, 00165 Rome, Italy.

Acute myeloid leukemia (AML) is a heterogeneous group of diseases, whose classification is based on lineage-commitment and genetics. Although rare in childhood, it is the most common type of acute leukemia in adults, accounting for 80% of all cases in this age group. The prognosis of this disease remains poor (especially in childhood, as compared to acute lymphoblastic leukemia); however, overall survival has significantly improved over the past 30 years. Read More

Oral Dis 2020 Jun 22. Epub 2020 Jun 22.

Division of Rheumatology and Clinical Immunology, Center of excellence for Systemic Sclerosis in Croatia, University Hospital Split, Split, Croatia.

We read with great interest recently published descriptive case-control study by Gomes da Silva et al. evaluating orofacial parameters in systemic sclerosis (SSc) patients (Gomes da Silva et al., 2019). Read More

Medicines (Basel) 2020 Jun 16;7(6). Epub 2020 Jun 16.

Unit of Gastroenterology, Molinette Hospital, 10126 Turin, Italy.

Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), can be associated with several extra-intestinal manifestations requiring a multidisciplinary management both in terms of work-up and therapy. Oral lesions are common in patients with IBD, with a prevalence ranging from 5% to 50%. These can represent an oral location of IBD as well as a side-effect of drugs used to treat the intestinal disease. Read More

SAGE Open Med Case Rep 2020 3;8:2050313X20927961. Epub 2020 Jun 3.

Department of Oral and Maxillofacial Surgery, Evangelismos General Hospital of Athens, Athens, Greece.

Lymphoblastic lymphoma, seen primarily in children or young adults, is a type of non-Hodgkin lymphoma that originates from B or T lymphocyte precursors and rarely occurs in the oral cavity. A case of systemic precursor T-cell lymphoblastic lymphoma mimicking periodontitis of a lower second molar in a 20-year-old adult is currently presented. The case was initially misdiagnosed as periodontal disease and treated with tooth extraction by a dentist. Read More

Semin Arthritis Rheum 2020 Jun 5;50(4):797-804. Epub 2020 Jun 5.

Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan.

Objective: Behcet's disease is a systemic disorder with ocular, mucocutaneous, and vascular involvement. The efficacy of tumor necrosis factor inhibition has been established; however, that of interluekin-6 inhibition is unclear. We investigated the effectiveness of tocilizumab, an anti-interleukin-6 receptor antibody, in patients with Behcet's disease. Read More

Int J Infect Dis 2020 Jun 9;97:326-328. Epub 2020 Jun 9.

Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasilia (UnB), Brasilia, Brazil. Electronic address:

Some oral manifestations have been observed in patients with coronavirus disease 2019 (COVID-19). However, there is still a question about whether these lesions are due to coronavirus infection or secondary manifestations resulting from the patient's systemic condition. Thus, this article aims to report an additional case of an oral condition in a patient diagnosed with COVID-19. Read More

Acta Stomatol Croat 2020 Mar;54(1):69-74

Department of Maxillofacial and Oral Surgery, University Hospital Dubrava, Zagreb.

Hyaline fibromatosis syndrome (HFS) is a rare autosomal recessive genetic disorder characterized by accumulation of hyalinized fibrous tissue with cutaneous, mucosal, osteoarticular, and systemic involvement. The condition is caused by a mutation of ANTXR2 gene that results in a faulty synthesis of a transmembrane protein which leads up to excessive deposition of hyaline material in extracellular space. The first signs may be present at birth or appear during infancy, and joint stiffness is the first, most common, symptom. Read More

Trials 2020 Jun 9;21(1):511. Epub 2020 Jun 9.

Department of Experimental and Clinical Medicine, School of Human Health Sciences, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.

Background: Behçet's syndrome (BS) is a systemic inflammatory disorder of unknown etiology, and it is characterized by a wide range of potential clinical manifestations. Recent evidence suggests that the gut microbiota (GM) in BS has low biodiversity with a significant depletion in butyrate producers. The aim of the present project is to investigate whether a dietary intervention could ameliorate the clinical manifestations and modulate the GM of individuals with BS. Read More

Pol Arch Intern Med 2020 Jun 3. Epub 2020 Jun 3.

The antiphospholipid syndrome (APS) is an autoimmune systemic disease characterized by a hypercoagulable state secondary to the presence of antiphospholipid antibodies (aPL) and associated to vascular thromboses and/or pregnancy complications. Although ≈60% of thrombotic manifestations is represented by venous thrombosis, also cardiovascular (CV) manifestations can occur in APS patients, comprising coronary and/or non-coronary complications. Moreover, several studies consistently showed a more significant atherosclerosis in APS patients than controls. Read More

Zhonghua Kou Qiang Yi Xue Za Zhi 2020 Jun;55(6):383-387

Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To investigate the clinical characteristics and imaging manifestations of primary bone lymphoma (PBL) located in the jaw. Clinical data of 14 PBL patients admitted to The First Affiliated Hospital of Zhengzhou University from January 2014 to April 2019 were retrospectively analyzed, which including age, gender, location, chief complaint, laboratory test, imaging manifestations and so on. Among the 14 PBL patients, 10 were male and 4 were female. Read More

Biomolecules 2020 May 19;10(5). Epub 2020 May 19.

College of Pharmacy, Keimyung University, Daegu 42601, Korea.

While liquiritigenin, isolated from , is known to possess anti-inflammatory activities, it still remains to be known whether liquiritigenin has a suppressive effect on T cell activation and T cell-mediated disease. Here, we used Jurkat T cells to explore an underlying mechanism of pre-treatment with liquiritigenin in activated T cell in vitro and used atopic dermatitis (AD) in vivo to confirm it. We found liquiritigenin blocks IL-2 and CD69 expression from activated T cells by PMA/A23187 or anti-CD3/CD28 antibodies. Read More

Curr Rheumatol Rep 2020 May 20;22(7):25. Epub 2020 May 20.

Inserm UMR_S 1116 and CHRU de Nancy, Vascular Medicine Division and Regional Competence Center For Rare Vascular And Systemic Autoimmune Diseases, Université de Lorraine, Nancy, France.

Purpose Of Review: The efficacy of direct oral anticoagulants (DOACs) in antiphospholipid syndrome (APS) is discussed. Results from randomized controlled trials are available. It has been stated that a history of arterial thrombosis and triple positivity was associated with a higher risk of thrombosis in APS patients treated with DOACs. Read More

Klin Monbl Augenheilkd 2020 May 20;237(5):591-598. Epub 2020 May 20.

Department für Augenheilkunde, Universitätsklinikum Tübingen.

Behçet's syndrome (BS) is an inflammatory systemic disease associated with multiple organ manifestations. Major symptoms include oral and genital ulcerations, skin lesions and uveitis. Diagnosis of Behçet's syndrome is based on clinical findings. Read More

Curr Pediatr Rev 2020 May 7. Epub 2020 May 7.

Pediatric Institute, Kuala Lumpur General Hospital, Kuala Lumpur. Malaysia.

Background: Henoch-Schönlein purpura (HSP) is an IgA-mediated systemic small-vessel vasculitis with a predilection for the skin, gastrointestinal tract, joints, and kidneys. It is the most common form of systemic vasculitis in children.

Objective: To familiarize physicians with the etiopathogenesis, etiology, clinical manifestations, evaluation, and management of children with Henoch-Schönlein purpura. Read More

Isr Med Assoc J 2020 May;22(5):289-293

Shine Rheumatology Institute, Rambam Health Care Campus, Haifa, Israel affiliated with Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background: Behçet's disease is a multi-systemic chronic relapsing inflammatory disease, classified among the vasculitides. The heterogeneity of clinical manifestations challenges the disease management.

Objectives: To assess efficacy and safety of adalimumab in patients with active persistent Behçet's arthritis who did not respond to disease-modifying anti-rheumatic drugs and to assess the impact of treatment on the cytokine milieu. Read More

Ann Med Surg (Lond) 2020 Jun 13;54:43-46. Epub 2020 Apr 13.

Baghdad Teaching Hospital, Rheumatology Unit, Baghdad, Iraq.

Background: Behçet's syndrome (BD) is a systemic inflammatory vasculitis of unknown aetiology, affecting vessels of different types, sizes and locations and characterized by recurrent episodes of acute inflammation, including mucocutaneous manifestations (oral aphthous ulcers, genital ulcers and skin lesions) and gastrointestinal, musculoskeletal, neurological, ophthalmic and vascular involvement which lead to a significant morbidity and impaired health related quality of life (HRQoL). Few studies reported impact of disease activity on HRQoL.

Objective: To assess the impact of BD activity on HRQoL. Read More

Lupus 2020 Jun 3;29(7):761-766. Epub 2020 May 3.

Institute of Biomedicine, Faculty of Medicine, Central University of Venezuela, Caracas, Venezuela.

Introduction: Lupus erythematosus (LE) is an autoimmune disease often treated with antimalarial drugs. The prolonged use of chloroquine and hydroxychloroquine can cause hyperpigmentation in the skin, oral mucosa and retinal pigment epithelium, which in turn can trigger toxicity in this epithelium, which in some cases causes vision loss. The objective of the present work was to establish the association between the presence of oral pigmented macules by antimalarial and secondary retinal toxicity. Read More

Lupus 2020 Jun 1;29(7):743-750. Epub 2020 May 1.

School of Nursing, Anhui Medical University, Anhui, PR China.

Introduction: The present study aimed to investigate the prevalence and influential factors of thrombocytopaenia in systemic lupus erythematosus (SLE) patients among the Chinese population in order to provide evidence for improving the treatment and nursing of SLE patients.

Methods: A retrospective analysis of 3140 SLE patients admitted to two large tertiary hospitals was conducted in Anhui, China, from 2011 to 2018. In addition, the influential factors related to SLE with thrombocytopaenia were analysed through univariate and multivariate analysis. Read More

Rheumatology (Oxford) 2020 May;59(Supplement_3):iii101-iii107

Department of Experimental and Clinical Medicine.

Behçet's syndrome (BS) is a systemic vasculitis characterized by a relapsing and remitting course. It can involve the skin, mucosa, joints, vessels (arteries and/or veins), eyes, and nervous and gastrointestinal systems, and so is referred to as a syndrome rather than as a unique and nosologically distinct condition. These involvements may present alone or co-exist in the same patient. Read More

J Clin Med 2020 Apr 19;9(4). Epub 2020 Apr 19.

Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany.

Objectives: The aim of this systematic review was to assess the oral-health-related quality of life (OHRQoL) of adult patients with rheumatic diseases.

Material And Methods: A systematic literature search was performed, including clinical studies on adults (aged at least 18 years) with a verified diagnosis of rheumatic disease.

Results: 26 out of 41 clinical studies including rheumatoid arthritis (RA, seven studies), systemic sclerosis (SSc, five), Sjögren syndrome (SS, eight), Behcet disease (BD, four), systemic lupus erythematosus (SLE, one) and ankylosing spondylitis (AS, one) were found. Read More

Rheumatol Int 2020 Jun 21;40(6):997-1000. Epub 2020 Apr 21.

Evangelismos General Hospital, 45-47 Ipsilantou Str, Athens, Greece.

IgA vasculitis, formerly known as Henoch-Schonlein purpura (HSP), is the most common form of systemic vasculitis in children and is characterized by inflammation of the small vessels with typical deposition of IgA immune complexes. It is a leukocytoclastic type of vasculitis and is characterized by a tetrad of clinical manifestations: non-thrombocytopenia or coagulopathy-induced palpable purpura, arthritis, or arthralgia, gastrointestinal, and renal involvement. The exact cause of IgA vasculitis is not known yet, although infections, vaccinations and insect bites have been implicated in the appearance of the disease. Read More

J Eur Acad Dermatol Venereol 2020 Apr 9. Epub 2020 Apr 9.

Pfizer Inc, Collegeville, PA, USA.

Background: Psoriatic arthritis (PsA) is a chronic, systemic immune-mediated inflammatory musculoskeletal disease. The onset of dermatologic symptoms often precedes rheumatic manifestations. Tofacitinib is an oral Janus kinase inhibitor for the treatment of PsA that has been shown to improve dermatologic symptoms in patients with PsA. Read More

Turk J Med Sci 2020 Mar 28. Epub 2020 Mar 28.

Behcet's disease (BD) is a systemic and inflammatory disorder mainly present along the ancient Silk Road, from Mediterranean Sea to East Asia. A wide range of prevalence figures (0.1-420/100. Read More

Ann Rheum Dis 2020 06 27;79(6):713-723. Epub 2020 Mar 27.

Rheumatology and Clinical Immunology Unit, "Attikon" University Hospital, Athens, Greece

Objective: To update the 2012 EULAR/ERA-EDTA recommendations for the management of lupus nephritis (LN).

Methods: Following the EULAR standardised operating procedures, a systematic literature review was performed. Members of a multidisciplinary Task Force voted independently on their level of agreeement with the formed statements. Read More

Arch Oral Biol 2020 May 14;113:104708. Epub 2020 Mar 14.

School of Stomatology, Anhui Medical University, Hefei, Anhui, China.

Objective: The important role of intestinal microbiota in systemic lupus erythematosus (SLE) has been recognized. Oral-gut microbiome axis is a crucial link in human health and disease, but few researches indicated the relationship between oral microorganisms and SLE. This study mainly explored the composition and changes of oral microorganisms in SLE patients with different stages, clinical manifestations and biomarkers. Read More

J Tradit Chin Med 2019 02;39(1):139-152

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.

Behcet's disease is a condition with a complicated and unclear etiology that comprises multi-systemic, chronic, inflammatory vasculitis. Behcet's disease can affect every tissue and organ in the body, and is characterized by recurrent oral and genital ulcers, ocular inflammation, skin lesions, and other manifestations. The incidence of Behcet's disease has a distinct regional specificity, and is most prevalent along the Silk Road, a route that stretched between the Mediterranean, Middle East and Far East. Read More

Eur J Paediatr Dent 2020 Mar;21(1):66-69

Department of Interdisciplinary Medicine, Aldo Moro University Bari, Italy.

Aim: Oro-facial granulomatosis is a descriptive term commonly encompassing a variety of conditions that exhibit similar clinical and microscopic features. It is generally used to describe persistent enlargement of the soft tissues of the oral and maxillofacial region.

Materials And Methods: We report on the salient clinical features of 8 cases of Crohn's disease in paediatric patients (age range from 9 to 13 years old), with oral lesions as first clinical manifestations. Read More

J Med Econ 2020 Jul 31;23(7):786-799. Epub 2020 Mar 31.

Health Economics Department, Janssen Pharmaceutical K.K, Tokyo, Japan.

To describe the characteristics and medication treatment patterns, healthcare resource utilization (HRU), and associated costs in Japanese patients with systemic lupus erythematosus (SLE). Claims data from the Japan Medical Data Center (JMDC) database were used to identify patients with SLE-related claims from 2010 to 2017. Algorithms were developed to retrospectively categorize patients by disease severity, treatment experience, and SLE-related manifestations such as lupus nephritis and central nervous system lupus. Read More

J Oral Pathol Med 2020 May 17;49(5):443-449. Epub 2020 Mar 17.

Department of Pathology, Dental School, University of São Paulo, São Paulo, Brazil.

Background: Reports of oral manifestations of granulomatosis with polyangiitis (GPA) usually refer to single-case reports; "strawberry gingivitis" has been increasingly reported.

Objective: To study the clinicopathological findings of four patients in which the diagnosis of GPA was suspected from the observation of their oral lesions and compare these to existent data.

Methods: Retrospective study of a case series. Read More

Eur J Case Rep Intern Med 2020 16;7(2):001354. Epub 2020 Jan 16.

Serviço de Medicina Interna, Hospital Beatriz Ângelo, Loures, Portugal.

Behçet's disease (BD) is a systemic vasculitis characterized by recurrent orogenital ulceration and several systemic manifestations (such as gastrointestinal involvement, vascular disease or arthritis). The pathogenesis is still unknown but the trigger role of certain pathogens such as is well documented. Furthermore, patients with BD are more susceptible to tuberculosis due to immunity defects. Read More

J Ophthalmic Vis Res 2020 Jan-Mar;15(1):99-103. Epub 2020 Feb 2.

Eye Research Center, Matini Eye Hospital, Kashan University of Medical Sciences, Kashan, Iran.

Purpose: To report a case of acute Vogt-Koyanagi-Harada (VKH) disease with unilateral clinical manifestations followed by late fellow eye involvement.

Case Report: This case report reviews the 12-month follow-up observation of a 44-year old woman who presented to the emergency department with unilateral progressive and painless visual blurring. Ophthalmoscopic findings, best-corrected visual acuity (BCVA), fluorescein angiography (FAG), enhanced-depth optical coherence tomography (EDI-OCT), indocyanine green angiography, and response to treatment were evaluated. Read More

Int Urol Nephrol 2020 Apr 2;52(4):731-738. Epub 2020 Mar 2.

Department of Nephrology, National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210016, China.

Objectives: We evaluated the clinical manifestations and outcomes of nocardiosis, a rare opportunistic infection that occurs in patients with nephrotic syndrome.

Methods: The records of NS patients with nocardiosis in a single hospital during 2000-2019 were retrieved and studied in detail.

Results: Eleven patients were included. Read More

Clin Exp Rheumatol 2020 Feb 18. Epub 2020 Feb 18.

Department of Internal Medicine and Autoimmune Diseases, Euroclinic of Athens, and Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.

Objectives: This study aims to characterise the clinical phenotype and autoantibody associations in an autoimmune population positive for anti-Ro52 and/or anti-Ro60 autoantibodies.

Methods: 508 sera of individuals tested for autoantibody presence were found positive for anti-Ro52 and/or anti-Ro60. Medical records were available for 272 of them. Read More

J Eur Acad Dermatol Venereol 2020 Feb 20. Epub 2020 Feb 20.

Department of Dermatology, Great Ormond Street Hospital for Children, London, UK.

Background: Paediatric localized scleroderma is a severe inflammatory disorder associated with tissue atrophy, often leading to disability. Assessing disease activity and response to treatment has always been challenging and remains an important difficulty in clinical practice.

Objectives: To investigate prospectively the efficacy of systemic treatment with corticosteroids and methotrexate in children with localized scleroderma and the validity of infrared thermography, laser Doppler flowmetry and high-frequency ultrasound in assessing disease activity. Read More

Liver Int 2020 Feb;40 Suppl 1:67-71

Département d'Hépatologie, Université Paris Centre, Hôpital Cochin, APHP, INSERM U1223, Institut Pasteur, Paris, France.

Background & Aims: HCV affects about 71 million people worldwide with 1.75 million new infections a year, mainly associated with healthcare, blood transfusion before screening of donors and drug use. Hepatitis C is a systemic disease with hepatic and extrahepatic manifestations resulting in increased morbidity and mortality in HCV-infected patients compared to cured or uninfected individuals. Read More

Oman Med J 2020 Jan 6;35(1):e84. Epub 2020 Jan 6.

Oral Basic Sciences, Oman Dental College, Muscat, Oman.

Objectives: We sought to determine the prevalence of immune-mediated skin disorders (IMDs), their oral manifestations, and the related comorbidity among Omani patients with IMDs attending the outpatient Department of Dermatology and Dental Clinic at Al Nahdha Hospital, Muscat.

Methods: We conducted a retrospective study of 236 newly-diagnosed patients with IMDs who attended the outpatient clinic between September 2014 and September 2017. Data, such as age, sex, investigations, diagnosis, comorbidity, and associated oral manifestations of the affected individuals, were collected from the hospital health information system. Read More

Int J Med Sci 2020 1;17(2):153-160. Epub 2020 Jan 1.

Department of Basic Medical Sciences, Neurosciences and Sensory Organs, "Aldo Moro" University of Bari, Italy.

: Systemic Lupus Erythematosus (SLE) is a connective tissue disease characterized by a wide range of pleomorphic pictures, including mucocutaneous, renal, musculoskeletal and neurological symptoms. It involves oral tissues, with hyposalivation, tooth decay, gingivitis, angular cheilitis, ulcers and glossitis. Temporomandibular disorders represent a heterogeneous group of inflammatory or degenerative diseases of the stomatognatic system, with algic and/or dysfunctional clinical features involving temporomandibular joint (TMJ) and related masticatory muscles. Read More

Orphanet J Rare Dis 2020 01 17;15(1):19. Epub 2020 Jan 17.

Clinical Neurosciences, Neurology, University of Helsinki and Helsinki University Hospital, HYKS, Tornisairaala, Neupkl, Haartmaninkatu 4, 00029 HUS, Helsinki, Finland.

Background: Hereditary gelsolin (AGel) amyloidosis is an autosomal dominantly inherited systemic amyloidosis that manifests with the characteristic triad of progressive ophthalmological, neurological and dermatological signs and symptoms. The National Finnish Gelsolin Amyloidosis Registry (FIN-GAR) was founded in 2013 to collect clinical data on patients with AGel amyloidosis, including altogether approximately one third of the Finnish patients. We aim to deepen knowledge on the disease burden and life span of the patients using data from the updated FIN-GAR registry. Read More

Open Access Maced J Med Sci 2019 Oct 10;7(19):3341-3347. Epub 2019 Oct 10.

Department of Prosthodontics and Dental Implantology, College of Dentistry, King Faisal University, Hofuf, Al-Ahsa Governorate, Saudi Arabia.

Background: Diagnosis of oral ulceration is always challenging and has been the source of difficulty because of the remarkable overlap in their clinical presentations.

Aim: The objective of this review article is to provide updated knowledge and systemic approach regarding oral ulcers diagnosis depending upon clinical picture while excluding the other causative causes.

Methods: For this, specialised databases and search engines involving Science Direct, Medline Plus, Scopus, PubMed and authentic textbooks were used to search topics related to the keywords such as oral ulcer, oral infections, vesiculobullous lesion, traumatic ulcer, systematic disease and stomatitis. Read More

Rom J Morphol Embryol 2019 ;60(3):955-961

Department of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania;

Behçet's disease is a multi-systemic vasculitis of small arteriolar and venular vessels, which shows a wide range of clinical manifestations, such as oral and genital aphthosis, erythema nodosum, panuveitis, complex gastrointestinal disorders, the early onset of neurological involvement being a negative prognostic factor in evolution. We present the case of a 36-year-old patient, who was admitted in the Clinic of Rheumatology for recurrent-neglected oral aphthosis, recurrent erythema nodosum, left hip pain, reduction of visual acuity of the right eye, weight loss, profuse sweating, marked fatigability. From the personal history was retained avascular necrosis of right femoral head, with arthroplasty at this level, human leukocyte antigen-B51 (HLA-B51) positive. Read More

An Bras Dermatol 2020 Jan - Feb;95(1):57-62. Epub 2019 Nov 30.

Dermatology Department, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Background: Sarcoidosis is a multisystem disease of unknown cause that is characterized by the presence of granulomas in various organs. Cutaneous involvement is common and the reported incidence has varied from 9% to 37%. Studies on cutaneous sarcoidosis in Brazil are lacking. Read More