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    1487 results match your criteria Oral Manifestations of Systemic Diseases

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    Long-term follow-up in primary Sjögren's syndrome reveals differences in clinical presentation between female and male patients.
    Biol Sex Differ 2017 Aug 8;8(1):25. Epub 2017 Aug 8.
    Unit of Experimental Rheumatology, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, SE-171 76, Stockholm, Sweden.
    Background: Despite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune diseases. In the present study, we aimed to investigate differences in the clinical presentation of primary Sjögren's syndrome (pSS) between the sexes and establish whether male sex is associated with a more severe form of long-term pSS.

    Methods: Our study population included 967 patients with pSS (899 females and 68 males) from Scandinavian clinical centers. Read More

    Common Oral Manifestations of Select Systemic Diseases: Anemia, Diabetes Mellitus and HIV.
    J Calif Dent Assoc 2016 09;44(9):553-9
    In this article, we discuss several common abnormal signs and symptoms that may be present in the oral cavity initially with or without any systemic symptoms at a typical dental practice. The purpose of this discussion is to increase clinical awareness for establishing differential diagnoses so that patients may obtain appropriate referrals for appropriate medical treatment. Read More

    Numb chin with mandibular pain or masticatory weakness as indicator for systemic malignancy - A case series study.
    J Formos Med Assoc 2017 Jul 17. Epub 2017 Jul 17.
    Department of Hemato-Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Background/purpose: Numb chin syndrome (NCS) is a critical sign of systemic malignancy; however it remains largely unknown by clinicians and dentists. The aim of this study was to investigate NCS that is more often associated with metastatic cancers than with benign diseases.

    Methods: Sixteen patients with NCS were diagnosed and treated. Read More

    Generalized Discoid Lupus Erythematosus as the Presenting Sign of Small Cell Lung Carcinoma.
    Skinmed 2017 1;15(3):218-220. Epub 2017 Jun 1.
    Department of Dermatology, Mayo Clinic, Rochester, MN.
    A 46-year-old woman with a 30 pack-year smoking history presented with a worsening eruption on the left cheek that failed to improve with metronidazole gel. The cutaneous eruption spread to most of her face and did not respond to a brief tapering course of prednisone. During the initial evaluation at our institution, approximately 6 weeks after the onset of the cutaneous eruption, the patient had erythematous, crusted plaques on her face and scalp (Figure 1A); they were also present on the V-area of the anterior aspect of the neck and upper region of the chest, the shoulders, and the arms, with isolated lesions on the trunk and legs. Read More

    Rare X chromosome abnormalities in systemic lupus erythematosus and Sjögren's syndrome.
    Arthritis Rheumatol 2017 Jul 10. Epub 2017 Jul 10.
    Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
    Background: Sjögren's syndrome and systemic lupus erythematosus (SLE) are related by clinical and serological manifestations as well as genetic risks. Both diseases are more commonly found in women compared to men at a ratio of about 10 to 1. Common X chromosome aneuploidies, 47,XXY and 47,XXX, are enriched among men and women, respectively, in either disease suggesting a dose effect on the X chromosome. Read More

    Oral manifestations of selective IgA-deficiency: review and case-report.
    J Biol Regul Homeost Agents 2017 Apr-Jun;31(2 Suppl 1):113-117
    Department of Surgical and Morphological Sciences, University of Insubria, Ospedale di Circolo Macchi Foundation, Unit of Oral Pathology, Varese, Italy.
    Immunoglobulin A deficiency is the most common primary immunodeficiency defined as decreased serum level of IgA (less than 7 mg/dl) in the presence of normal levels of other immunoglobulin isotypes. Most individuals with IgA deficiency are asymptomatic and identified coincidentally. However, some patients may present with recurrent infections, allergic disorders and autoimmune manifestations, such as diabetes mellitus, Graves disease and celiac disease. Read More

    Skin Manifestations of Inflammatory Bowel Disease.
    Clin Rev Allergy Immunol 2017 Jun 23. Epub 2017 Jun 23.
    Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
    Inflammatory bowel disease (IBD) with its two main subtypes Crohn's disease and ulcerative colitis is not restricted to the gastrointestinal tract. Indeed, so-called extraintestinal manifestations (EIMs) are frequent and considerably affect morbidity and mortality. The prevalence of EIMs ranges from 6 to 47%. Read More

    Clinical characteristics of acute hepatitis A outbreak in Taiwan, 2015-2016: observations from a tertiary medical center.
    BMC Infect Dis 2017 Jun 20;17(1):441. Epub 2017 Jun 20.
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5 Fuhsing Street, Kueishan, Taoyuan, 333, Taiwan.
    Background: Acute hepatitis A is a fecal-oral transmitted disease related to inadequate sanitary conditions. In addition to its traditional classification, several outbreaks in the men who have sex with men (MSM) population have resulted in acute hepatitis A being recognized as a sexually transmitted disease. However, few studies have clarified the clinical manifestations in these outbreaks involving the MSM population. Read More

    [Chronic stress and mental disorders in patients with systemic scleroderma: Results of an interdisciplinary study].
    Ter Arkh 2017;89(5):26-32
    Moscow Research Institute of Psychiatry, Branch, V.P. Serbsky Federal Medical Research Center of Psychiatry and Narcology, Ministry of Health of Russia, Moscow, Russia.
    Aim: To analyze of the prevalence of stressful factors and mental disorders (MDs), as well as their clinical psychopathological and clinical psychological characteristics to improve the comprehensive diagnosis and treatment of systemic scleroderma (SSD).

    Subjects And Methods: Examinations were performed in 110 patients (predominantly women (n=97 (88.2%); mean age, 49. Read More

    Microbiota and Probiotics in Health and HIV Infection.
    Nutrients 2017 Jun 16;9(6). Epub 2017 Jun 16.
    Unit of Immunodiagnostic and Molecular Pathology, Department of Medical, Oral and Biotechnological Sciences, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy.
    Microbiota play a key role in various body functions, as well as in physiological, metabolic, and immunological processes, through different mechanisms such as the regulation of the development and/or functions of different types of immune cells in the intestines. Evidence indicates that alteration in the gut microbiota can influence infectious and non-infectious diseases. Bacteria that reside on the mucosal surface or within the mucus layer interact with the host immune system, thus, a healthy gut microbiota is essential for the development of mucosal immunity. Read More

    Genome-wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus.
    Arthritis Res Ther 2017 Jun 15;19(1):138. Epub 2017 Jun 15.
    Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, 08035, Spain.
    Background: Systemic lupus erythematosus (SLE) is a genetically complex rheumatic disease characterized by heterogeneous clinical manifestations of unknown etiology. Recent studies have suggested the existence of a genetic basis for SLE heterogeneity. The objective of the present study was to identify new genetic variation associated with the clinically relevant phenotypes in SLE. Read More

    The Diagnosis and Treatment of Sjögren's Syndrome.
    Dtsch Arztebl Int 2017 May;114(20):354-361
    Charité Center for Internal Medicine, Medical Department-Division of Rheumatology and Clinical Immunology, Berlin, Germany; University Clinic of Rheumatology, Immunology and Allergology, Inselspital Bern, Bern, Switzerland; BfA Wendelstein Rehabilitation Clinic, Rheumatology Center, AHB Clinic, Bad Aibling, Germany; Department of Ophthalmology, Charité Campus Virchow, Berlin, Germany; Oral Surgery, The School of Dentistry, University of Birmingham, United Kingdom.
    Background: Sjögren's syndrome is one of the more common inflammatory rheumatological diseases, with a prevalence of at least 0.4% in Germany.

    Methods: This review is based on pertinent articles retrieved by a selective search in PubMed. Read More

    A case report of the orbit, ocular association and the lung in granulomatosis with polyangiitis: A diagnostic challenge.
    Exp Ther Med 2017 Jun 28;13(6):3337-3340. Epub 2017 Apr 28.
    Department of Ophthalmology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
    Granulomatosis with polyangiitis (GPA) is a systemic form of vasculitis that involves small to medium sized vessels and is associated with high morbidity and mortality. GPA presents a continuous and difficult clinical diagnostic concern, due to the rarity of the disease and the diversity of the manifestations. This case report discusses the unusual symptoms presented by a particular patient, discusses these manifestations and explains how the final diagnosis was identified as GPA. Read More

    Leprosy in an Eight-Year-Old Child - An Exceptional Case with Unusual Oral Manifestation.
    J Clin Diagn Res 2017 Apr 1;11(4):ZD19-ZD20. Epub 2017 Apr 1.
    Senior Lecturer, Department of Oral Medicine and Radiology, Maharana Pratap College of Dentistry and Research Centre, Gwalior, Madhya Pradesh, India.
    Leprosy is a contagious and granulomatous disease which is caused by Mycobacterium leprae. The incubation period for leprosy is five to seven years and it can take as long as about 30 years before signs and symptoms of leprosy develop in some patients. It is a chronic systemic disease which mostly affects the skin and peripheral nerves. Read More

    The association of pathergy reaction and active clinical presentations of Behçet's disease.
    Reumatologia 2017 28;55(2):79-83. Epub 2017 Apr 28.
    Medical Biology Research Center, Kermanshah University of Medical Sciences, Iran.
    Objectives: The pathergy skin test is a hypersensitivity reaction to a prick skin trauma caused by a pin or a needle, which is considered as a specific presentation in Behçet's disease (BD) and the precise mechanism of this test is not well elucidated. This study was designed to evaluate the association of pathergy reaction (PR) with the active clinical manifestations of BD patients, to assess the clinical importance of PR.

    Materials And Methods: This was a cohort study on 1675 BD patients who fulfilled the entry criteria based on the International Criteria for Behçet's Disease (ICBD) from 1975 to 2011. Read More

    Can Inspection of the Mouth Help Clinicians Diagnose Crohn's Disease? A Review.
    Oral Health Prev Dent 2017 ;15(3):223-227
    Purpose: Crohn's disease (CD) is a chronic inflammatory bowel disease characterised by localised areas of nonspecific, noncaseating granulomas. Approximately 1/3 of CD patients develop extraintestinal manifestations in the course of their disease. This review focuses on oral manifestations of CD to understand if oral lesions could help clinicians in the diagnosis of systemic CD. Read More

    Cardiac tamponade as an initial presentation for systemic lupus erythematosus.
    Am J Emerg Med 2017 Aug 29;35(8):1213.e1-1213.e4. Epub 2017 Apr 29.
    Cardiology, Lincoln Medical and Mental Health Center, United States.
    Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease which follows a relapsing and remitting course that can manifest in any organ system. While classic manifestations consist of arthralgia, myalgia, frank arthritis, a malar rash and renal failure to name a few, cardiac tamponade, however, is a far less common and far more dangerous presentation. We highlight the case of a 61year-old male with complaints of acute onset shortness of breath and generalized body aches associated with a fever and chills in the ER. Read More

    Systemic manifestations of primary Sjögren's syndrome in the NOD.B10Sn-H2(b)/J mouse model.
    Clin Immunol 2017 May 17. Epub 2017 May 17.
    Department of Oral Biology, School of Dental Medicine, University of Buffalo, The State University of New York, Buffalo, NY 14214, USA; Autoimmune Division, Trinity Biotech, 60 Pineview Drive, Buffalo, NY 14228, USA; Department of Oral Diagnostics Sciences, School of Dental Medicine, University of Buffalo, The State University of New York, Buffalo, NY 14214, USA. Electronic address:
    Animal models that recapitulate human disease are crucial for the study of Sjögren's Syndrome (SS). While several SS mouse models exist, there are few primary SS (pSS) models that mimic systemic disease manifestations seen in humans. Similar to pSS patients, NOD. Read More

    Coexistence of ulcerative colitis and Sjögren's syndrome in a patient with Takayasu's arteritis and Hashimoto's thyroiditis.
    Intest Res 2017 Apr 27;15(2):255-259. Epub 2017 Apr 27.
    Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea.
    A 31-year-old woman with a 15-year history of Takayasu's arteritis (TA) and a 13-year history of Hashimoto's thyroiditis presented with hematochezia. She received a diagnosis of Sjögren's syndrome at 1 month before her visit to Kyungpook National University Medical Center. Her colonoscopic findings were compatible with a diagnosis of ulcerative colitis (UC). Read More

    Pemphigus.
    Nat Rev Dis Primers 2017 May 11;3:17026. Epub 2017 May 11.
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
    Pemphigus is a group of IgG-mediated autoimmune diseases of stratified squamous epithelia, such as the skin and oral mucosa, in which acantholysis (the loss of cell adhesion) causes blisters and erosions. Pemphigus has three major subtypes: pemphigus vulgaris, pemphigus foliaceus and paraneoplastic pemphigus. IgG autoantibodies are characteristically raised against desmoglein 1 and desmoglein 3, which are cell-cell adhesion molecules found in desmosomes. Read More

    Oral Ulcers in Juvenile-Onset Systemic Lupus Erythematosus: A Review of the Literature.
    Am J Clin Dermatol 2017 May 5. Epub 2017 May 5.
    Center of Excellence in Immunology and Immune-mediated Disease, Faculty of Medicine, Chulalongkorn University, Rama 4 Road, Pathumwan, Bangkok, 10330, Thailand.
    Oral ulcers are the most common mucosal sign in juvenile-onset systemic lupus erythematosus (JSLE). The ulcers are one of the key clinical features; however, the terminology of oral ulcers, especially in JSLE patients, is often vague and ill-defined. In fact, there are several clinical manifestations of oral ulcers in JSLE, and some lesions occur when the disease is active, indicating that early management of the disease should be started. Read More

    Systemic mastocytosis with KIT V560G mutation presenting as recurrent episodes of vascular collapse: response to disodium cromoglycate and disease outcome.
    Allergy Asthma Clin Immunol 2017 24;13:21. Epub 2017 Apr 24.
    Consulta Multidisciplinar de Linfomas Cutâneos e Mastocitoses (CMLC), Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal.
    Background: Mastocytosis are rare diseases characterized by an accumulation of clonal mast cells (MCs) in one or multiple organs or tissues. Patients with systemic mastocytosis (SM), whose MCs frequently arbor the activating D816V KIT mutation, may have indolent to aggressive diseases, and they may experience MC mediator related symptoms. Indolent SM with recurrent anaphylaxis or vascular collapse in the absence of skin lesions, ISMs(-), is a specific subtype indolent SM (ISM), and this clonal MC activation disorder represents a significant fraction of all MC activation syndromes. Read More

    Innate immunity in Sjögren's syndrome.
    Clin Immunol 2017 Apr 8. Epub 2017 Apr 8.
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY 14214, United States; Department of Oral Diagnostic Sciences, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY 14214, United States. Electronic address:
    Sjögren's syndrome (SS) is an autoimmune disease of exocrine tissue that primarily affects women. Although patients typically experience xerostomia and xerophthalmia, numerous systemic disease manifestations are seen. Innate immune hyperactivity is integral to many autoimmune diseases, including SS. Read More

    Reviewing primary Sjögren's syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment.
    Int J Med Sci 2017 23;14(3):191-200. Epub 2017 Feb 23.
    Department of Internal Medicine, Division of Clinical Immunology;; Department of Immunology, Erasmus MC, Rotterdam, The Netherlands.
    Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease, characterized by lymphocytic infiltration of the secretory glands. This process leads to sicca syndrome, which is the combination of dryness of the eyes, oral cavity, pharynx, larynx and/or vagina. Extraglandular manifestations may also be prevalent in patients with pSS, including cutaneous, musculoskeletal, pulmonary, renal, hematological and neurological involvement. Read More

    Photodynamic inactivation of Paracoccidioides brasiliensis helps the outcome of oral paracoccidiodomycosis.
    Lasers Med Sci 2017 May 27;32(4):921-930. Epub 2017 Mar 27.
    Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, Brazil.
    The antifungal drug therapy often employed to treat paracoccidiodomycosis (PCM), an important neglected fungal systemic infection, leads to offensive adverse effects, besides being very long-lasting. In addition, PCM compromises the oral health of patients by leading to oral lesions that are very painful and disabling. In that way, photodynamic therapy (PDT) arises as a new promising adjuvant treatment for inactivating Paracoccidioides brasiliensis (Pb), the responsible fungus for PCM, and also for helping the patients to deal with such debilitating oral lesions. Read More

    HIV Infection and Compromised Mucosal Immunity: Oral Manifestations and Systemic Inflammation.
    Front Immunol 2017 7;8:241. Epub 2017 Mar 7.
    Faculty of Medicine and Dentistry, Department of Dentistry, University of Alberta, Edmonton, AB, Canada; Faculty of Medicine and Dentistry, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
    Mucosal surfaces account for the vast majority of HIV transmission. In adults, HIV transmission occurs mainly by vaginal and rectal routes but rarely via oral route. By contrast, pediatric HIV infections could be as the result of oral route by breastfeeding. Read More

    Oral Viral Infections: Diagnosis and Management.
    Dent Clin North Am 2017 Apr;61(2):351-363
    Department of Oral and Maxillofacial Surgery, Woodhull Medical Center, 760 Broadway, Room 2C-320, Brooklyn, NY 11206, USA.
    This article focuses on common viral infections in the oral cavity with associated systemic manifestations. Discussed are the clinical features, histopathology, diagnosis, treatment, and prevention of viral infections in oral cavity. This will be a useful aid for general practitioners and other dental personnel wanting to expand their pathologic knowledge. Read More

    Treatment of Renal Angiomyolipoma and Other Hamartomas in Patients with Tuberous Sclerosis Complex.
    Clin J Am Soc Nephrol 2017 Jul 16;12(7):1196-1202. Epub 2017 Mar 16.
    Renal Disease and Hypertension, Pediatric Nephrology and Hypertension, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas
    Tuberous sclerosis complex is an autosomal dominant genetic disease characterized by growth of benign tumors (hamartomas) in multiple organs, especially the kidneys, brain, heart, lungs, and skin. Tuberous sclerosis complex is usually caused by a mutation in either the tuberous sclerosis complex 1 or tuberous sclerosis complex 2 gene, resulting in constitutive activation of mammalian target of rapamycin signaling. Currently, mammalian target of rapamycin inhibitors are recommended in adult patients with tuberous sclerosis complex for the treatment of asymptomatic, growing renal angiomyolipoma that are >3 cm in diameter and pediatric or adult patients with brain lesions (subependymal giant cell astrocytoma) that either are growing or are not amenable to surgical resection. Read More

    An oral lesion as the primary clinical manifestation of sarcoidosis.
    Ann R Coll Surg Engl 2017 May 16;99(5):e135-e136. Epub 2017 Mar 16.
    Mid Essex Hospital Services NHS Trust , UK.
    An oral lesion as the first clinical presentation of sarcoidosis is extremely rare. We present the case of a 39-year-old woman who was referred to the oral and maxillofacial surgery department with a persistent asymptomatic nodular lesion in the hard palate. This was located adjacent to a grossly carious upper first molar and a provisional diagnosis of chronic periapical granuloma was made. Read More

    Amyloidosis and Anesthesia.
    Anesth Essays Res 2017 Jan-Mar;11(1):233-237
    Department of Anaesthesiology and Critical Care, NIMS Medical College and Hospital, Jaipur, Rajasthan, India.
    Aim: The aim of this article is to provide a view of amyloidosis and discuss implications for the anesthetic management of patients with this condition.

    Material And Method: Urine samples from patients with plasma cell dyscrasias were obtained from a urine bank that gathers urine samples from patients who gave research use consent for specimens that would otherwise be considered waste.

    Results: Patients with amyloidosis may present to the anesthesiologist for procedures relating to diagnosis, surgery relating to the underlying condition (e. Read More

    Comparison of Disease Characteristics, Organ Damage, and Survival in Patients with Juvenile-onset and Adult-onset Systemic Lupus Erythematosus in a Combined Cohort from 2 Tertiary Centers in Turkey.
    J Rheumatol 2017 May 15;44(5):619-625. Epub 2017 Mar 15.
    From the Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University; Division of Rheumatology, Department of Pediatrics, Cerrahpaşa Faculty of Medicine, Istanbul University; Department of Statistics, Faculty of Arts and Sciences, Yıldız Technical University; Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
    Objective: Age at onset has been shown to affect the clinical course and outcome of systemic lupus erythematosus (SLE). Herein, we aimed to define the differences in clinical characteristics, organ damage, and survival between patients with juvenile-onset (jSLE) and adult-onset SLE (aSLE).

    Methods: For the study, 719 patients (76. Read More

    Severe Systemic Lead Toxicity Resulting From Extra-Articular Retained Shrapnel Presenting as Jaundice and Hepatitis: A Case Report and Review of the Literature.
    Mil Med 2017 Mar;182(3):e1843-e1848
    Department of Preventive Medicine and Public Health, Blanchfield Army Community Hospital, 2576 23rd Street, Fort Campbell, KY 42223.
    Introduction: Despite greater than 60,000 nonfatal firearm injuries per year in the United States, retained shrapnel is a relatively rare cause of systemic lead toxicity with less than 100 cases reported in the medical literature since 1867. While intra-articular retained shrapnel as a cause of lead toxicity is well-described, extra-articular fragments are less well known to cause symptomatic disease.

    Case Report: A 31-year-old man initially presented with abdominal pain, constipation, jaundice, and elevated liver transaminases approximately 3 weeks after suffering a left lower extremity injury during athletic activity. Read More

    Cytokine Signatures in Mucocutaneous and Ocular Behçet's Disease.
    Front Immunol 2017 27;8:200. Epub 2017 Feb 27.
    Department of Emergency and Organ Transplantation, Rheumatology Unit, University of Bari Aldo Moro , Bari , Italy.
    Behçet's disease (BD) is a multi-systemic inflammatory disorder consisting of recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis; however, many other organs may be affected. Several pro-inflammatory cytokines, mainly derived from Th1 and Th17 lymphocytes, seem to be involved in different pathogenic pathways leading to development of the clinical manifestations. On this basis, the primary aim of our study was to compare a core set of pro-inflammatory cytokines between patients with BD and healthy control (HC). Read More

    Oral Pyoderma Gangrenosum: Diagnosis, Treatment and Challenges: A Systematic Review.
    Head Neck Pathol 2017 Mar 8. Epub 2017 Mar 8.
    Oral and Maxillofacial Pathologist, Department of Stomatology, Faculty of Dentistry, Universite de Montreal, Montreal, QC, Canada.
    Pyoderma gangrenosum (PG) is a distinctive ulcerative skin disorder of unknown etiology, associated with an underlying systemic disease in up to 70% of cases. The condition is characterized by the appearance of one or more necrotic ulcers with a ragged undermined violaceous border and surrounding erythema. Lesions are often initiated by minor trauma. Read More

    A meta-analysis of avascular necrosis in systemic lupus erythematosus: prevalence and risk factors.
    Clin Exp Rheumatol 2017 Jul-Aug;35(4):700-710. Epub 2017 Feb 24.
    Division of Rheumatology, Department of Medicine, Joseph's Health Care, London, Canada.
    Objectives: To determine the prevalence of and risk factors for avascular necrosis (AVN) in systemic lupus erythematosus (SLE).

    Methods: MEDLINE, CINAHL, Web of Science, EMBASE and Cochrane Library were searched from inception to July, 2015 and a random effects model was used to combine frequencies; study quality was assessed using STROBE.

    Results: 2,041 citations identified 62 articles. Read More

    Contemporary Use of Corticosteroids in Rhinology.
    Curr Allergy Asthma Rep 2017 Feb;17(2):11
    Department of Otorhinolaryngology, School of Medicine, University of Crete, Heraklion, Crete, Greece.
    Purpose Of Review: Exogenously administered corticosteroids are widely used today in the field of rhinology. Allergic rhinitis (AR), non-allergic rhinitis (NAR), acute rhinosinusitis (ARS), chronic rhinosinusitis with (CRSwNP) and without (CRSsNP) nasal polyps, and autoimmune disorders with nasal manifestations are common diseases treated effectively with intranasal and oral glucocorticoids. We focus on physiological pathways, therapeutic benefits, indications, contra-indications, and side effects of glucocorticoid utilization in the treatment of rhinologic disorders such as AR, NAR, ARS, CRSsNP, and CRSwNP. Read More

    Tuberculosis 'The Great Imitator': A usual disease with unusual presentations.
    Indian J Tuberc 2017 Jan 4;64(1):54-59. Epub 2016 Jul 4.
    Lecturer, Dept. of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, India.
    Background: A number of infectious diseases have been referred to by the phrase 'The Great Imitator', of which the oldest is syphilis; others include Lyme disease, nocardiosis, etc. Tuberculosis has been described as the second great imitator as it can imitate various other disease processes. An awareness of the atypical clinical manifestations of tuberculosis is important, especially in regions where tuberculosis continues to be a major public health problem, such as India. Read More

    Three Cases of Erdheim-Chester Disease With Intraocular Manifestations: Imaging and Histopathology Findings of a Rare Entity.
    Am J Ophthalmol 2017 Apr 30;176:141-147. Epub 2017 Jan 30.
    The Rotterdam Eye Hospital, Rotterdam, Netherlands.
    Purpose: To report intraocular manifestations of Erdheim-Chester Disease (ECD) with multimodal imaging.

    Design: A retrospective observational case series.

    Methods: This was a multicenter case series of 3 patients with confirmed tissue diagnosis of ECD that showed intraocular manifestations and were imaged at baseline and follow-up visits. Read More

    Autoimmune Disease Manifestations in the Oral Cavity.
    Surg Pathol Clin 2017 Mar 28;10(1):57-88. Epub 2016 Dec 28.
    Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida, 1395 Center Drive, Gainesville, FL 32610, USA.
    Immune-related disorders of the oral cavity may occur as primary disease process, secondary to systemic disease or neoplasm, or as a reaction to medications and other agents. The entities represented within this group may vary significantly by severity, clinical presentation, microscopic presentation, and special testing results. The selected immune-related conditions of the oral cavity in this article are categorized and presented by their prototypical tissue reaction patterns: vesiculobullous, including acantholytic and subepithelial separation; psoriasiform; spongiotic; and lichenoid reaction patterns. Read More

    Evaluation of olfactory function in Behçet's disease.
    Eur J Rheumatol 2016 Dec 1;3(4):153-156. Epub 2016 Dec 1.
    Division of Rheumatology, Department of Internal Medicine, Ondokuz Mayıs University School of Medicine, Samsun, Turkey.
    Objective: Behçet's disease (BD) is a chronic, relapsing type of vasculitis of unknown etiology and is characterized by oral and urogenital ulcers and ocular inflammation with cutaneous, musculoskeletal, vascular, and nervous system manifestations. Few cases involving the nasal mucosa have been reported in the literature, and the true prevalence of BD remains unknown. Neurological involvement associated with BD might play a more important role in causing olfactory dysfunction than mucosal involvement, but sufficient clinical data are not available on the effect of BD on olfaction in adults. Read More

    [Fabry disease].
    Ann Dermatol Venereol 2017 Feb 16;144(2):137-146. Epub 2017 Jan 16.
    Département de dermatologie, Hôpital Hôtel-Dieu de France, Faculté de médecine, Université Saint-Joseph, Beyrouth, Liban.
    Fabry disease, also known as Anderson-Fabry disease or angiokeratoma corporis diffusum universale, is an X-linked recessive form of sphingolipidosis caused by total or partial deficiency of the lysosomal hydrolase, alpha-galactosidase A. From the youngest age, it results in a gradual ubiquitous build-up of glycosphingolipids that are not degraded by the missing enzyme. Cutaneous, neurological, nephrologic, cardiac, gastrointestinal, ophthalmological, respiratory, cochleovestibular and haematological involvement are responsible for increased mortality and significant impairment of quality of life in subjects affected by the disease. Read More

    Mechanisms and New Strategies for Primary Sjögren's Syndrome.
    Annu Rev Med 2017 Jan;68:331-343
    Department of Physiology, School of Medicine and Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Athens, Greece; email:
    Primary Sjögren's syndrome (SS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, mainly salivary and lacrimal, resulting in oral and ocular dryness, although virtually any organ system can be affected. SS-related systemic manifestations are classified as either related to the presence of periepithelial infiltrates in exocrine and parenchymal organs or resulting from immunocomplex deposition due to B cell hyperactivity with increased risk for B cell lymphoma development. Activation of both innate and adaptive immune pathways contributes to disease pathogenesis, with prominent interferon (IFN) signatures identified in both peripheral blood and affected salivary gland tissues. Read More

    Oral mucous membrane pemphigoid and pemphigus vulgaris-a retrospective two-center cohort study.
    Oral Dis 2017 May 22;23(4):498-504. Epub 2017 Feb 22.
    Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.
    Objectives: Few studies have compared oral mucous membrane pemphigoid (MMP) and pemphigus vulgaris (PV). Descriptive analysis of oral features, extent of extra-oral involvement, and management outcomes were performed.

    Subjects And Methods: Patients with PV and MMP, the latter with exclusive oral involvement at first presentation, were included. Read More

    ANA-Negative Presentation of SLE in Man with Severe Autoimmune Neutropenia.
    Case Rep Med 2016 19;2016:6853936. Epub 2016 Dec 19.
    University of California San Diego School of Medicine, La Jolla, CA, USA.
    Background. Systemic lupus erythematosus (SLE) is a chronic, inflammatory, connective tissue disease that commonly affects the joints and a variety of organs due to an overactivation of the body's immune system. There is wide heterogeneity in presentation of SLE patients, including lung, central nervous system, skin, kidney, and hematologic manifestations. Read More

    Systemic alterations and their oral manifestations in pregnant women.
    J Obstet Gynaecol Res 2017 Jan;43(1):16-22
    Clinica Odontologica, Federal University of Maranhao, São Luís, Brazil.
    The aims of this literature review are: to depict the main oral diseases that are related to pregnancy; to clarify some of the possible systemic mechanisms that are associated with these changes; and to address issues about oral care during pregnancy. A woman's organs undergo various physiological, neurological, and hormonal changes during pregnancy. Such changes occur gradually and are essential for the development of the fetus, providing what is needed for tissue formation and establishment of reserves for uterine and fetal life. Read More

    Oral manifestations of gastrointestinal diseases in children. Part 4: Coeliac disease.
    Eur J Paediatr Dent 2016 Dec;17(4):332-334
    Department of Surgical sciences and Integrated Diagnostics, University of Genova, Genoa, Italy.
    Alterations within the oral cavity can be the first sign of systemic diseases and may thus allow for an early diagnosis and treatment. In particular, being the oral cavity part of the gastrointestinal system, oral alterations can be an expression of a gastrointestinal disease. Dental enamel hypoplasia and aphthous ulcers have been found to be more common in children with coeliac disease compared with the general population and to regress after the patient is started on a gluten free-diet. Read More

    Orofacial granulomatosis as early manifestation of Crohn's disease: report of a case in a paediatric patient.
    Eur J Paediatr Dent 2016 Dec;17(4):318-321
    1st Department of Pediatrics, Medical School, University of Athens, Aghia Sophia Children's Hospital, Athens, Greece.
    Background: Orofacial granulomatosis (OFG) is a controversial entity mainly characterised by recurrent or permanent soft tissue swelling of sudden onset in the orofacial area with a histologic appearance of granulomatous inflammation. Differential diagnosis includes local diseases and systemic conditions, such as Crohn's disease (CD). A case of OFG in a paediatric patient is reported here, focusing on the clinical features, diagnostic procedures, treatment and long-term outcome. Read More

    Steinert syndrome and repercussions in dental medicine.
    Arch Oral Biol 2017 Mar 23;75:37-47. Epub 2016 Dec 23.
    Health Sciences Faculty, Fernando Pessoa University, Porto, Portugal. Electronic address:
    Steinert syndrome, also called myotonic dystrophy type 1, is a genetic disorder with autosomal dominant transmission characterized by myotonia and a multisystemic clinical picture that affects several tissues of the human body. The most common systemic phenotypes are: muscular, cardiac, respiratory, CNS, ocular, gynecological, digestive, orthopedical, as well as cognitive and psychological symptoms (cognitive decline). Muscles involved in voluntary movement are highly affected by myotonia especially distal muscles of upper limbs. Read More

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