1,033,856 results match your criteria Oral Manifestations of Systemic Diseases
J Public Health Dent 2018 Dec 14. Epub 2018 Dec 14.
Section of Population Oral Health, Columbia University College of Dental Medicine, New York, NY, USA.
Objectives: To identify and characterize US early childhood caries (ECC) programs.
Methods: A 39 question online survey was fielded to 245 ECC programs identified from the literature and peer programs. The 101 respondents (41 percent response rate) reported their program's geographic reach, type, areas of focus, target populations, approaches, affiliations, providers, goals, costs, and funding. Read More
J Public Health Dent 2018 Dec 14. Epub 2018 Dec 14.
Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia.
Objectives: This study explored the association of children's salivary characteristics, past caries experience, birth weight, and reported maternal prenatal vitamin and mineral supplementation with the dental untreated decay of the child.
Methods: This cross-sectional study, a sub-study of Griffith University Environments for Healthy Living birth cohort study, was conducted on 174 mother-child dyads. Mother's prenatal usage of vitamin and mineral supplements; child's birthweight; salivary pH, buffering capacity, and levels of salivary MS and LB were explored as risk indicators. Read More
J Crit Care 2018 Dec 6;50:155-161. Epub 2018 Dec 6.
Medical and Surgical Intensive Care Unit, Groupe Hospitalier Paris Saint Joseph, Paris, France; Endotoxins, Structures and Host Response, Department of Microbiology, Institute for Integrative Biology of the Cell, UMR 9891 CNRS-CEA-Paris Saclay University, 98190 Gif-sur-Yvette, France. Electronic address:
Ventilator-associated pneumonia remain frequent and serious diseases since they are associated with considerable crude mortality. Pathophysiology is centered on modifications of regional bacterial flora, especially tracheobronchial tree and oropharyngeal sphere. Bacterial migration from an anatomical area to another seems to be the main explanation of these alterations which are called "transcolonization". Read More
Thromb Res 2018 Dec 6;174:16-23. Epub 2018 Dec 6.
Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
Background: Patients with warfarin have a potential risk of warfarin-related nephropathy, which could result in the discontinuation of anticoagulation therapy. The question of whether non-vitamin K antagonist oral anticoagulants (NOACs) use is associated with increased risk of renal impairment in atrial fibrillation (AF) patients remains unanswered.
Methods: Studies were systematically searched through Medline, Embase, Cochrane Library databases, and ClinicalTrials. Read More
Pharmacol Rep 2018 Oct 11;71(1):156-166. Epub 2018 Oct 11.
Department of Pharmaceutical Technology, Medical University of Bialystok, Białystok, Poland. Electronic address:
Skin application of pharmaceutical products is one of the methods used for drug administration. The problem of limited drug penetration via topical application makes searching for safe drug carriers that will provide an expected therapeutic effect of utmost importance. Research into safe drug carriers began with liposome structures, paving the way for work with nanocarriers, which currently play a large role as drug vehicles. Read More
Pharmacol Rep 2018 Oct 11;71(1):149-155. Epub 2018 Oct 11.
School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD, Australia; Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD, Australia. Electronic address:
Background: Inflammatory bowel disease (IBD) is an important cause of chronic disability in humans.
Methods: We characterized a model of chronic IBD in young male Wistar rats by administering dextran sodium sulfate (DSS: 0%, 0.25%, 0. Read More
Behav Brain Res 2018 Dec 11. Epub 2018 Dec 11.
The Brain and Muscle Energy Group, Electron Microscopy Laboratory, Department of Oral Biology, University of Oslo, NO-0316 Oslo, Norway; Synaptic Neurochemistry and Amino Acid Transporters Labs, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences (IMB) and Healthy Brain Ageing Centre (SERTA), University of Oslo, NO-0317 Oslo, Norway; Center for Healthy Aging, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
The energy deficit hypothesis of attention-deficit/hyperactivity disorder (ADHD) suggests that low lactate production by brain astrocytes causes the symptoms of the disorder. Astrocytes are the main producers of lactate in the brain; however, skeletal muscles can produce the most lactate in the body. The lactate production by skeletal muscles increases with physical activity, as does the expression of the lactate transporter monocarboxylate transporter 1 (MCT1) at the blood-brain barrier (BBB). Read More
Int J Infect Dis 2018 Dec 11. Epub 2018 Dec 11.
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Background: Hand, foot and mouth disease (HFMD) has been associated with large outbreaks among young children, including severe illness and fatality, in the Asia-Pacific Region since 1997. Severe illness is often associated with enterovirus A71 (EV-A71). Vietnam experienced a large sustained outbreak of 200. Read More
J Control Release 2018 Dec 11. Epub 2018 Dec 11.
Department of Micro- and Nanotechnology, Technical University of Denmark, Oersteds Plads 345C, 2800 Kgs., Lyngby, Denmark.
Oral vaccines are highly desirable due to simple logistics, mass vaccination potential and for mucosal immunity. Subunit vaccines are preferred due to high safety, but are inherently difficult to deliver orally, thus providing motivation for the use of advanced oral delivery systems. Polymeric devices in micrometer size (microcontainers) were tested here for this purpose. Read More
Sci Total Environ 2018 Dec 5;657:509-516. Epub 2018 Dec 5.
China National Center for Food Safety Risk Assessment, Beijing 100022, China. Electronic address:
Hand, foot and mouth disease (HFMD) remains an increasing public health concern. The spatiotemporal variation of HFMD can be represented from multiple-perspectives, and it may be driven by different dominant factors. In this study, the HFMD cases in children under the age of five years in each county in Henan province, China, from 2009 to 2013 were assessed to explore the integrative spatiotemporal patterns of HFMD and investigate their driving factors. Read More
Heart Rhythm 2018 Dec 11. Epub 2018 Dec 11.
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Background: Stroke risk stratification scores (e.g., CHADS-VASc) are used to tailor therapeutic recommendations for patients with atrial fibrillation (AF) in different risk groups. Read More
Mol Cell Endocrinol 2018 Dec 11. Epub 2018 Dec 11.
Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquímica y Ciencias Biológicas, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional del Litoral, Santa Fe, Argentina. Electronic address:
The aim of the present study was to compare the effect of oral and subcutaneous exposure to a glyphosate-based herbicide (GBH) on the female reproductive system, specifically in the ovaries and uterus of prepubertal lambs. To this end, ewe lambs were exposed to a s.c. Read More
Ann Allergy Asthma Immunol 2018 Dec 11. Epub 2018 Dec 11.
Kaiser Permanente Southern California Region, Department of Allergy and Research and Evaluation, San Diego and Pasadena, CA.
Cell 2018 Dec;175(7):1756-1768.e17
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard University Medical School, Boston, MA 02115, USA. Electronic address:
Irisin is secreted by muscle, increases with exercise, and mediates certain favorable effects of physical activity. In particular, irisin has been shown to have beneficial effects in adipose tissues, brain, and bone. However, the skeletal response to exercise is less clear, and the receptor for irisin has not been identified. Read More
J Oral Maxillofac Surg 2018 Nov 20. Epub 2018 Nov 20.
Department Head, Department of Oral and Maxillofacial Surgery, Sheba Medical Center, Tel-Hashomer, Affiliated to Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Purpose: To evaluate 3-dimensional orofacial changes that occurred after proportional condylectomy that was not followed by orthognathic surgery in patients with condylar hyperplasia type 1B (unilateral hemimandibular elongation).
Materials And Methods: This retrospective analysis used the medical records of 14 skeletally mature patients. Transverse, vertical, and horizontal cephalometric analyses of photographs and radiographs were undertaken. Read More
Int J Pharm 2018 Dec 11. Epub 2018 Dec 11.
Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
Screw feeders are integrated as dispensing units in most continuous manufacturing platforms. Hence, characterizing and modelling the residence time distribution (RTD) of materials in feeders is indispensable to understand the traceability of raw materials from the drum till tablet, enabling the separation of non-confirming material. The proposed methodology addressed this leap in knowledge by characterizing materials, performing RTD trials according to an experimental design, applying RTD models and establishing a partial least square (PLS) regression model that links the material properties and process variables with the RTD responses as outputs. Read More
PLoS One 2018 14;13(12):e0208886. Epub 2018 Dec 14.
Dental Research Centers, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
Objective: Gingivitis and poor oral hygiene status are the most prevalent oral diseases among primary school students. Poor oral hygiene status, gingivitis and socio-demographic determinants have been shown to be associated with periodontal diseases. There is limited information on the gingivitis and oral hygiene status among Iranian children. Read More
PLoS One 2018 14;13(12):e0208383. Epub 2018 Dec 14.
Karolinska Institutet, Dept NVS, Division for Neurogeriatrics, Bioclinicum, Akademiska stråket, Solna, Sweden.
Background: The GGGGCC repeat expansion in the C9orf72 gene was recently identified as a major cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in several European populations. The objective of this study was to determine the frequency of C9orf72 repeat expansions in a Bulgarian dementia cohort and to delineate the associated clinical features.
Methods And Findings: PCR-based assessments of the C9orf72 hexanucleotide repeat expansion in all study samples (including 82 FTD, 37 Alzheimer's disease (AD), and 16 other neurodegenerative/dementia disorder cases) were performed. Read More
J Nurs Care Qual 2018 Dec 12. Epub 2018 Dec 12.
Clinical Nutrition, Sodexo Healthcare, Gaithersburg, Maryland (Ms Siegel and Mr Higgins); Department of Agricultural Economics, Mississippi State University, Starkville, Mississippi (Dr Fan); Catholic Heath Initiatives, Denver, Colorado (Ms Goldman); and Health Economics and Outcomes Research, Abbott Nutrition Research and Development, Columbus, Ohio (Drs Goates and Partridge).
Background: Despite its high prevalence, malnutrition in hospitalized patients often goes unrecognized and undertreated.
Local Problem: A hospital system sought to improve nutrition care by implementing a quality improvement initiative. Nurses screened patients upon admission using the Malnutrition Screening Tool and initiated oral nutrition supplements for patients at risk. Read More
J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.
Department of Plastic Surgery, University of Virginia Health System.
Appropriate management of lower 3rd molars is crucial to successful treatment of mandibular angle fractures. A unique case of a patient who presented for initial management of a left mandibular angle fracture with an unerupted lower 3rd molar was discussed in this study. After treatment with open reduction and internal fixation of the fracture, the lower 3rd molar erupted and the patient subsequently developed fungal osteomyelitis and hardware failure. Read More
J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.
Department of Oral and Maxillofacial Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Stomatology, Shanghai, China.
Objective: The aim of the study was to explore an optimal surgery way for head and neck rhabdomyosarcoma (HNRMS) children who have failed primary chemotherapy.
Methods: A total of 51 HNRMS children who have failed primary chemotherapy were retrospectively analyzed from April 2005 to May 2017. Surgery was performed in 2 ways, widely radical resection (22 patients) and conservative resection (29 patients). Read More
Curr Med Res Opin 2018 Dec 14:1-21. Epub 2018 Dec 14.
d National Research Institute , Los Angeles , CA , USA .
Objective: The LixiLan clinical trials of insulin glargine (iGlar)/lixisenatide fixed-ratio combination (iGlarLixi) investigated the safety and efficacy of iGlarLixi versus iGlar: LixiLan-O (NCT02058147) in patients with type 2 diabetes (T2D) inadequately controlled on oral antidiabetes drugs (OADs), and LixiLan-L (NCT02058160) in patients with T2D inadequately controlled on basal insulin ± OADs. In these two trials, both iGlar and iGlarLixi were titrated to a maximum (capped) dose of 60 units. We evaluated whether this may have affected the reported glycemic efficacy of iGlar, and the glycemic differences observed between treatment with iGlarLixi and iGlar. Read More
Curr Med Res Opin 2018 Dec 14:1-16. Epub 2018 Dec 14.
a Department of Endocrinology , The First Affiliated Hospital of Dalian Medical University , Dalian , PR China.
Objective: To compare the efficacy and safety of a twice-daily injection of insulin aspart (BIAsp) 30 and BIAsp50 in patients with type 2 diabetes mellitus (T2DM) poorly controlled with oral hypoglycaemic agents (OHAs).
Methods: In this 12-week prospective, randomized, parallel trial, a total of 80 T2DM patients, 59 ± 10 years old with a disease duration of 9.3 ± 6. Read More
J Exp Psychol Learn Mem Cogn 2018 Dec 13. Epub 2018 Dec 13.
Department of Psychology.
People prefer words with consonant articulation locations moving inward, from the front to the back of the mouth (e.g., ), over words with consonant articulation locations moving outward, from the back to the front of the mouth (e. Read More
Pol J Microbiol 2018 ;67(4):525-528
Department of Biophysics, Faculty of Medicine, Near East University , Nicosia , Cyprus.
Hepatitis E virus (HEV) is transmitted by a fecal oral route from animals to humans following exposure to the body fluids of infected animals. We investigated the seroprevalence of anti-hepatitis E (anti-HEV) antibodies by monitoring IgG and IgM virus antibodies amongst employees in the animal industry in North Cyprus through a cross-sectional study. Samples were taken from individuals without occupational exposure to animals and from those who worked with animals (doing animal husbandry, veterinary work or butchery). Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1483-1486
Department of Otorhinolaryngology Head and Neck Surgery, Shaanxi Provincial People's Hospital.
To investigate the clinical value of the seven-item Eustachian Tube Dysfunction Questionnaire(ETDQ-7) in evaluating Eustachian tube dysfunction before and after treatment. A retrospective analysis of 50 patients with Eustachian tube dysfunction diagnosed. All the patients were given chymotrypsin 4 000 IU and dexamethasone injection 5 mg by blowing through the Eustachian tube under nasal endoscopic guidance once daily for 3-6 consecutive days. Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1434-1435
A 33-year-old man presented with recurrent oral ulcers for more than 10 years,accompanying dyspnea and dysphagia for 1 year and aggravate for 1 month.Physical examination:pharyngeal cavity stenosis,mucous retention, epiglottis was extruded into the infant type. Electronic laryngoscope:Epiglottis curl,bilateral pyriform sinus disappeared. Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1422-1425
Department of Respiration of North China University of Science and Technology Affiliated Hospital, 063000, China.
To explore the effect of butylphthalide on oxidative stress and cognitive function in old obstructive sleep apnea hypopnea syndrome (OSAHS)patients.A total of 90 old OSAHS patients with cognitive impairment were choosed with Polysomnography（PSG）. By random number table method OSAHS patients were randomly divided into non-invasive ventilator group (=30), butylphthalide with non-invasive ventilator group(=30) and treatment group of butylphthalide(=30). Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1065-1070
Department of Otolaryngology Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
The purpose of this study was to summarize preliminary clinical experience of transoral robotic surgery (TORS) in laryngeal and hypopharyngeal tumors with da Vinci surgical system.Twelve patients were reviewed who were diagnosed with laryngeal (=7) and hypopharyngeal tumors (=5) and treated with TORS in Beijing Anzhen Hospital from July 1, 2016 to January 31, 2018.Ten cases were male and two cases were female. Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1048-1050;1055
Department of Otolaryngology, Sun Yat-sen Memorial Hospital,Sun Yat-sen University, Guangzhou, 510120, China.
Surgery is one of the salvage treatments for recurrent nasopharyngeal carcinoma. The safety and efficacy of Da Vinci's robotic surgery was preliminarily investigated to resect recurrent nasopharyngeal cancer after one-course radiotherapy.Since Oct 2017, Da Vinci surgery system was used to complete the operation of locally recurrent nasopharyngeal carcinoma including two approaches, such as trans oral with soft palate incision and trans oral and nose with soft palate suspended. Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1917-1922
Total laryngectomy is a common method for the treatment of malignant tumors of the pharynx and larynx in China, but pharyngocutaneous fistula often happens after surgery, which burdens patients and affects postoperative recovery. At present, there are many measures to prevent pharyngocutaneous fistula, including strengthening nutrition pre-operative and post-operative, testing related indicators, controlling comorbidities, rational use of drugs, regular oral care, optimal selection of incision closure, and using of flaps and special materials during operation, etc. However, the choice of specific program needs to take care of the patient's condition, surgeon's skills and hospital conditions, and often requires multiple programs to be used together throughout the perioperative period. Read More
G Ital Nefrol 2018 Dec;35(6)
Department of Oral Surgery, Faculty of Dental medicine, Medical University, Plovdiv, Bulgaria.
Introduction: End-stage chronic kidney disease (CKD) is characterized by kidney failure with the organ's functions reduced or lost completely, where the kidneys are incapable of filtering excess fluids. Renal replacement therapy may be provided by peritoneal dialysis, hemodialysis or renal transplantation. Among the key indicators for tracking patients' current status are urea and creatinine levels. Read More
J Clin Psychiatry 2018 Nov 27;80(1). Epub 2018 Nov 27.
Department of Psychiatry and Health Behaviors, Augusta University Health, Augusta, Georgia, USA.
Objective: To investigate subgroup responses to long-acting injectable (LAI) medications haloperidol decanoate (HD) and paliperidone palmitate (PP) in a randomized controlled trial that found no difference between the treatments on the primary outcome of efficacy failure.
Methods: A Comparison of Long-Acting Injectable Medications for Schizophrenia (ACLAIMS) enrolled 311 participants from March 2011 to July 2013 meeting DSM-IV-TR criteria for diagnoses of schizophrenia or schizoaffective disorder at risk of relapse due to medication nonadherence or substance abuse. Participants were randomly assigned to double-blinded treatment with HD or PP and followed for up to 2 years. Read More
Mol Inform 2018 Dec 14. Epub 2018 Dec 14.
Department of Earth and Environmental Sciences, University of Milano-Bicocca, P.za della Scienza 1, 20126, Milano, Italy.
The ICCVAM Acute Toxicity Workgroup (U.S. Department of Health and Human Services), in collaboration with the U. Read More
Head Neck 2018 Dec 14. Epub 2018 Dec 14.
Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
Background: The study aimed to define indocyanine green (ICG) kinetics to determine the optimal ICG dose and surgical time for near-infrared fluorescence-guided oral cancer surgery.
Methods: Spectrometer and grayscale digital imaging were used to quantify the ICG kinetics in 12 patients with oral cancer. The fluorescence intensity and signal-to-background ratio (SBR) of tumor and normal tissue were tested at 1, 6, and 24 hours after ICG injection. Read More
Macromol Biosci 2018 Dec 14:e1800376. Epub 2018 Dec 14.
School of Chemical Engineering, Sichuan University, Chengdu, 610065, China.
Defective osteogenesis and latent infections continue to be two major issues in the therapy of bone tissue regeneration. In this study, a unique hierarchically micro/nanoscale-architecture is first proposed and produced on polyetheretherketone (PEEK). Besides, a "simvastatin-PLLA film-tobramycin microspheres" delivery system is subsequently fabricated to endow the PEEK implant with osteogenic and antibacterial capabilities. Read More
Head Neck 2018 Dec 14. Epub 2018 Dec 14.
Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine, Houston, Texas.
Background: Following salvage total laryngectomy (STL) with microvascular-free tissue transfer (MFTT), patients are at high risk for swallowing dysfunction, but risk factors for persistent gastrostomy tube (G-tube) dependence are unknown.
Methods: Retrospective review of 33 patients who underwent STL with MFTT.
Results: A total oral diet was achieved by 81% of patients with ≥6 months of postoperative follow-up. Read More
Head Neck 2018 Dec 14. Epub 2018 Dec 14.
Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Background: Biomarkers that could predict malignant transformation of recurrent respiratory papillomatosis (RRP) would be useful in patient follow-up. We investigated whether serum matrix metalloproteinase 8 (MMP-8) and tissue inhibitor of metalloproteinase 1 (TIMP-1) could predict malignant transformation of RRP and whether they associate with survival in laryngeal squamous cell carcinoma (LSCC) without preexisting RRP.
Methods: We analyzed serum MMP-8 (S-MMP-8) and serum TIMP-1 (s-TIMP-1) in 114 patients: 55 were treated for RRP and 59 for LSCC without preexisting RRP. Read More
Head Neck 2018 Dec 14. Epub 2018 Dec 14.
Centre for Life Sciences, School of Natural Sciences, Central University of Jharkhand, Ranchi, Jharkhand, India.
Background: Bax, a proapoptotic protein but its regulation during oral cancer progression and resistance remains elusive.
Methods: A total of 127 samples including adjacent normal, primary tumor, and resistance to chemoradiation therapy (RCRT) samples from oral squamous cell carcinoma (OSCC) patients were used. The status of Bax was analyzed at DNA/mRNA/protein levels and the results were correlated with p53 and Akt expression in tissue samples/cisplatin-resistant oral tongue SCC (SCC9/SCC4-CisR) cell line. Read More
Laryngoscope 2018 Dec 14. Epub 2018 Dec 14.
Department of Oral Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
Objective: To analyze the metastasis rate in intraglandular lymph nodes (IGLNs) with a focus on discussing the significance of IGLN metastasis in local control (LC) of parotid gland cancer (PGC).
Methods: A total of 337 patients were enrolled. Information including age; sex; and pathologic variables such as tumor (T) stage, IGLN metastasis, and follow-up findings was extracted and analyzed. Read More
Int Endod J 2018 Dec 14. Epub 2018 Dec 14.
School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.
Aim: To investigate the prevalence, location, and pattern of preexisting microcracks in non-endodontically treated teeth from fresh cadavers. Micro-computed tomography (micro-CT) technology was used as the analytical tool enabling full screening of the root dentine with the teeth retained in their original alveolar socket.
Methodology: As a pilot study and to validate the present method, a series of 4 high-resolution scans were performed on one bone-block specimen with teeth collected postmortem: (i) entire bone-block including the teeth, (ii) second molar tooth extracted atraumatically from the bone-block (iii) extracted tooth dehydrated to induce dentinal defects and (iv) entire bone-block following reinsertion of the extracted tooth into its matching alveolar socket. Read More
J Periodontol 2018 Dec 14. Epub 2018 Dec 14.
Department of Conservative Dentistry and Periodontology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.
Background: A major mediator of angiogenesis is angiogenin which is expressed in the early phase of healing in oral tissue engineering strategies. It is unclear how angiogenin is regulated in the periodontal tissue. The objective of this study was to reveal the regulation of angiogenin in response to hypoxia and the hypoxia mimetic agent L-mimosine in periodontal fibroblasts METHODS: Human fibroblasts of the periodontal ligament (PDLF) and the gingiva (GF) in monolayer and spheroid cultures were exposed to hypoxia or L-mimosine. Read More
J Periodontol 2018 Dec 14. Epub 2018 Dec 14.
Division of Oral Diseases, Department of Dental Medicine, Karolinska Institute, Stockholm, Sweden.
Aim: To evaluate the cytokine, chemokine and growth factor levels in peri-implant sulcular fluid (PISF) during healing and osseointegration at osteotomy sites prepared either with piezosurgery (PS) or drills.
Materials And Methods: Fourteen patients having contralateral partial edentulism in the posterior maxilla were enrolled and 38 osteotomies were prepared. Implants were placed with one-stage surgery. Read More
Clin Pharmacol Ther 2018 Dec 14. Epub 2018 Dec 14.
Division of Clinical Pharmacology, Medical Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, MO.
This study investigated the impact of SLCO1B1 genotype on pravastatin systemic exposure in hypercholesterolemic children and adolescents. Participants (8-20 years) with at least one allelic variant of SLCO1B1 c.521T>C (521TC, n=15; 521CC, n=2) and wild type controls (521TT, n=15) completed a single oral dose pharmacokinetic study. Read More
Asia Pac J Clin Oncol 2018 Dec 13. Epub 2018 Dec 13.
Department of Internal Medicine II, Osaka Medical College, Takatsuki, Osaka, Japan.
Aim: Gastric cancer patients are normally treated with oral fluoropyrimidine and cisplatin or oxaliplatin; however, treating patients who also have a gastrointestinal obstruction is often difficult because of their poor oral intake. Instead, a modified (m)FOLFOX-6 regimen is administered, even to patients with gastrointestinal obstructions. The aim of this study was to assess the efficacy of mFOLFOX-6 for gastric cancer patients with a gastrointestinal obstruction. Read More
J Int AIDS Soc 2018 Dec;21(12):e25214
AIDS and TB Unit, The Ministry of Health and Child Care, Harare, Zimbabwe.
Introduction: Heat-stable lopinavir/ritonavir (LPV/r) oral pellets were developed to overcome challenges with administration and storage experienced with previously available tablet and syrup forms of LPV/r prescribed to paediatric HIV patients. We report on the adoption of LPV/r pellets for infants living with HIV in the public sector antiretroviral therapy (ART) programme in Zimbabwe.
Methods: Infants aged three months to three years who had been prescribed a LPV/r-based regimen (including ART-naïve patients) in fourteen facilities across the country were eligible to receive the pellets. Read More
J Biomed Mater Res A 2018 Dec 13. Epub 2018 Dec 13.
Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, FORM (Frankfurt Orofacial Regenerative Medicine) Lab, University Hospital Frankfurt Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
The biomaterials physicochemical characteristics influence their cellular reaction, degradation and regenerative capacities. Macrophages and multinucleated giant cells (MNGCs) are observed in the augmentation area of biomaterials. This study, for the first time, evaluated the polarization pattern of macrophages and MNGCs in response to two different bone substitute materials (synthetic bone substitute material (SBSM) = NanoBone® vs. Read More
Head Neck 2018 Dec 14. Epub 2018 Dec 14.
Department of Pathology, University of Turku and Turku University Hospital, Turku, Finland.
Background: Nasopharyngeal carcinoma (NPC) is related to Epstein-Barr virus (EBV) in endemic areas; however, the role of viruses in nonendemic countries is unclear. Our nationwide study investigated the prevalence and prognostic significance of EBV and human papillomaviruses (HPVs) in Finnish NPC tumors.
Methods: We analyzed samples from 150 patients diagnosed between 1990 and 2009. Read More
Cancer Sci 2018 Dec 14. Epub 2018 Dec 14.
Department of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute, Tokyo, Japan.
Recently, there has been an increased attention to circulating tumor cells (CTCs) analysis, also known as liquid biopsy, owing to its potential benefits in cancer diagnosis and treatment. CTCs are released from primary tumor lesions into the blood stream and eventually metastasize to distant body organs. However, a major hurdle with CTC analysis is their natural scarcity. Read More
Head Neck 2018 Dec 14. Epub 2018 Dec 14.
Swallowing Systems Core, Departments of Speech, Language and Hearing Sciences and Neurology, University of Florida, Gainesville, Florida.
Background: We aimed to: (1) examine relationships between the Functional Oral Intake Scale (FOIS), Eating Assessment Tool-10 (EAT-10), and objective measures of swallowing (Modified Barium Swallow Impairment Profile [MBSImP©] and penetration-aspiration scale [PAS]) in patients with head and neck cancer, (2) compare outcomes between oral intake vs tube-dependent patients, and (3) compare outcomes across time points.
Methods: A total of 58 patients with head and neck cancer completed the FOIS, EAT-10, and underwent a standardized videofluoroscopy (VFSS). VFSS were analyzed using the PAS and MBSImP©. Read More