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    1529 results match your criteria Oral Manifestations of Systemic Diseases

    1 OF 31

    Anti-interleukin 6 receptor tocilizumab in refractory uveitis associated with Behçet's disease: multicentre retrospective study.
    Rheumatology (Oxford) 2018 Feb 19. Epub 2018 Feb 19.
    Rheumatology Division and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain.
    Objective: To assess the efficacy of tocilizumab (TCZ) in refractory uveitis of Behçet's disease (BD).

    Methods: Multicentre study of patients with BD-associated uveitis. Patients were refractory to conventional and biologic immunosuppressive drugs. Read More

    The lupus patient with positive rheumatoid factor.
    Lupus 2018 Jan 1:961203318759607. Epub 2018 Jan 1.
    1 Rheumatology Service, Evangelical University Hospital of Curitiba, Curitiba, Brazil.
    Background Patients with systemic lupus erythematosus (SLE) may form clusters with clinical manifestations and autoantibodies. Objective The objective of this report is to study whether SLE patients with positive rheumatoid factor (RF) have a special clinical and/or serological profile. Methods A retrospective study of 467 SLE patients seen at a single rheumatology unit was conducted. Read More

    A child with tubulointerstitial nephritis and uveitis (TINU) syndrome.
    BMJ Case Rep 2018 Feb 17;2018. Epub 2018 Feb 17.
    Unidade de Nefrologia e Transplantação Renal Pediátrica, Departamento de Pediatria, Hospital de Santa Maria - Centro Hospitalar de Lisboa Norte, Lisboa, Portugal.
    Tubulointerstitial nephritis and uveitis syndrome is an uncommon disease, probably underdiagnosed in clinical practice. Its aetiology and pathogenesis remain unknown. This syndrome is defined by an association of uveitis and tubulointerstitial nephritis, with no evidence of systemic disease or infection that might cause both ocular and renal inflammation. Read More

    Tuberculous gingival enlargement: A rare clinical manifestation.
    J Indian Soc Periodontol 2017 Mar-Apr;21(2):156-159
    Department of Periodontics, Sri Ramakrishna Dental College and Hospital, Coimbatore, Tamil Nadu, India.
    Tuberculosis (TB) is an inflammatory granulomatous disease that rarely presents as primary lesion in gingiva. Gingival involvement has been reported in only a very limited number of cases. A 13-year-old boy presented with gingival enlargement in the maxillary and mandibular anterior region associated with enlargement of lower lip with no systemic manifestations. Read More

    [Dermatological features of auto-inflammatory recurrent fevers].
    Arch Pediatr 2018 Feb 1;25(2):150-162. Epub 2018 Feb 1.
    Université Paris-Saclay, university Paris-Sud, CHU de Bicêtre, 78, avenue du Général-Leclerc, Le-Kremlin-Bicêtre, France.
    Auto-inflammatory diseases are characterized by unexplained and recurrent attacks of systemic inflammation often involving the skin, joints, or serosal membranes. They are due to a dysfunction or dysregulation of the innate immunity, which is the first line of defense against pathogens. Early recognition of these diseases by the clinician, especially by pediatricians encountering such pathologies in pediatric patients, is primordial to avoid complications. Read More

    Optimal management of Cogan's syndrome: a multidisciplinary approach.
    J Multidiscip Healthc 2018 22;11:1-11. Epub 2017 Dec 22.
    Department of Sense Organs, Sapienza University of Rome, Rome, Italy.
    Cogan's syndrome (CS) is a rare disorder characterized by nonsyphilitic interstitial keratitis (IK) and audio-vestibular symptoms. CS affects mainly young Caucasian adults, mostly during their first three decades of age, and may develop into typical and atypical variants. Typical CS manifests primarily with IK and hearing loss, whereas atypical CS usually presents with inflammatory ocular manifestations in association with audio-vestibular symptoms but mostly different Ménière-like symptoms and, more frequently, with systemic inflammation (70%), of which vasculitis is the pathogenic mechanism. Read More

    A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease.
    Ann Rheum Dis 2018 Jan 9. Epub 2018 Jan 9.
    Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.
    Objectives: The association between mutations in, encoding the NF-kB regulatory protein A20, and a new autoinflammatory disease has recently been recognised. This study aims at describing the clinical phenotypes and disease course of patients with A20 haploinsufficiency (HA20).

    Methods: Data for all cases from the initial publication, and additional cases identified through collaborations since, were collected using standardised data collection forms. Read More

    Diseases of the lips.
    Clin Dermatol 2017 Sep - Oct;35(5):e1-e14. Epub 2017 Nov 16.
    Department of Oral Pathology, Medicine, Radiology, Indiana University School of Dentistry, Indianapolis, IN; Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN.
    Heath care providers should be comfortable with normal as well as pathologic findings in the lips, because the lips are highly visible and may display clinical manifestations of local, as well as systemic inflammatory, allergic, irritant, and neoplastic alterations. Fortunately, the lips are easily accessible. The evaluation should include a careful history and physical examination, including visual inspection, as well as palpation of the lips and an examination of associated cervical, submandibular, and submental nodes. Read More

    A national cohort study on pediatric Behçet's disease: cross-sectional data from an Italian registry.
    Pediatr Rheumatol Online J 2017 Dec 21;15(1):84. Epub 2017 Dec 21.
    Pediatric Rheumatology Unit, AOU Meyer, University of Florence, Florence, Italy.
    Background: Behçet's disease is a rare multi-systemic inflammatory disease with unknown etiology which involves principally oral and genital mucosa, skin and eyes. Average age at onset of the disease is about 25-30 years, but it may be diagnosed before the age of 16. It is not very rare in Italy, even though there are limited data concerning epidemiology. Read More

    Bullous Pemphigoid Masquerading as Erythema Annulare Centrifugum.
    Acta Dermatovenerol Croat 2017 Oct;25(3):255-256
    Sheng-Yiao Lin, No. 100, Tzyou 1st Road, Kaohsiung 807, Taiwan;
    Dear Editor, Bullous pemphigoid (BP), a relatively common autoimmune blistering disease in the elderly, is characterized by large, tense bullae on urticarial, erythematous, or normal skin. However, atypical BP with polymorphic clinical presentations is rarely encountered, leading to misdiagnosis and delayed treatments (1). BP with lesions resembling erythema gyratum repens or figurate erythema has been regarded as a paraneoplastic phenomenon (1). Read More

    Morphea in Childhood: An Update.
    Actas Dermosifiliogr 2017 Dec 13. Epub 2017 Dec 13.
    Servicio de Dermatología, Hospital Universitario Infanta Cristina , Parla, Madrid, España.
    Morphea is an inflammatory, fibrosing skin disorder. When it occurs in childhood, it is also known as localized juvenile scleroderma. It is more common in girls and typically appears around the age of 5 to 7 years. Read More

    Multiple aneurysms and gastrointestinal involvement in Behcet's disease: A case report.
    Medicine (Baltimore) 2017 Dec;96(49):e9131
    aDepartment of Nephrology and Rheumatology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinabSingapore Thong Chai Medical Institution, Singapore.
    Rationale: Behcet's disease (BD) is a rare systemic vasculitis disorder that can involve vessels of any size.

    Patient Concerns: A 60-year-old female had recurrent painful mouth ulcers about 30 years ago and recently presented with abdominal distension, conjunctival congestion, and chest pain in sequence.

    Diagnoses: The patient was diagnosed with BD according to the International Criteria for Behcet's Disease (ICBD). Read More

    Systemic lupus erythematosus and ocular involvement: an overview.
    Clin Exp Med 2017 Dec 14. Epub 2017 Dec 14.
    Department of Basic Medical Sciences, Neurosciences and Sensory Organ, University of Bari Medical School, Clinica Oculistica, Policlinico, Piazza Giulio Cesare, 70124, Bari, Italy.
    Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease of undefined etiology and with remarkably heterogeneous clinical features. Virtually any organ system can be affected, including the eye. SLE-related eye involvement can be diagnosed in approximately one-third of the patients and is usually indicative of disease activity. Read More

    The histopathology of Erdheim-Chester disease: a comprehensive review of a molecularly characterized cohort.
    Mod Pathol 2017 Dec 1. Epub 2017 Dec 1.
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    Erdheim-Chester disease is a rare, non-Langerhans cell histiocytosis histologically characterized by multi-systemic proliferation of mature histiocytes in a background of inflammatory stroma. The disease can involve virtually any organ system; most commonly the bones, skin, retroperitoneum, heart, orbit, lung, and brain are affected. Although a histiocytic proliferation is the histological hallmark of the disease, a wide range of morphological appearances have been described as part of case studies or small series. Read More

    Orofacial Bacterial Infectious Diseases: An Update.
    J Int Soc Prev Community Dent 2017 Oct 30;7(Suppl 2):S61-S67. Epub 2017 Oct 30.
    Department of Oral Pathology, Dental Research Center, Research Centre for Molecular Medicine, Dental Faculty, Hamadan University of Medical Sciences, Hamadan, Iran.
    Objectives: Most of the oral infections with odontogenic origin are very common and can be treated by tooth extraction, endodontic therapy, or surgical treatment. Other infectious lesions are the manifestations of systemic diseases such as tuberculosis and syphilis. Skin and underlying subcutaneous tissue, fascia, or muscle is also involved with infectious diseases which range from superficial epidermal infections to very serious necrotizing fasciitis. Read More

    Anticoagulant use in atrial fibrillation and risk of dementia: review of contemporary knowledge.
    Expert Rev Cardiovasc Ther 2017 Dec;15(12):897-903
    a Intermountain Medical Center , Intermountain Heart Institute , Murray , UT , USA.
    Introduction: Atrial fibrillation (AF) is strongly associated with dementia, including idiopathic dementias such as Alzheimer's disease. The relative risk of dementia is highest in AF patients 70 years and younger, and the burden of exposure to arrhythmia appears to underlie part of the risk. Areas covered: Anticoagulation choices and approach influence dementia risk. Read More

    Comparative evaluation of oral and dento-maxillofacial manifestation of patients with sickle cell diseases and beta thalassemia major.
    Hematology 2017 Nov 22:1-6. Epub 2017 Nov 22.
    c Research and Development Laboratory , Javid Biotechnology Company, Incubator of Pasteur institute of Iran , Tehran , Iran.
    Background: Regarding the importance of oral and dental health in patients with hemoglobinopathies and also due to the different results of different studies in this background, in patients with beta thalassemia (BTM) and sickle cell disease (SCD), this study aimed to evaluate and compare the oral and dental manifestations of patients with BTM and SCD.

    Material And Methods: In this cross-sectional study during the years 2014-2017, a total of 175 patients (with documented BTM or SCD attending to Tehran, Mashhad, Isfahan, and Tabriz cities central hospitals) were randomly recruited. Required information was gathered through a thorough physical examination of the oral cavity in a private office and a face-to-face interview by an orthodontist and two dentists. Read More

    Current and novel approaches for control of dental biofilm.
    Int J Pharm 2018 Jan 21;536(1):199-210. Epub 2017 Nov 21.
    Formulation Development Laboratory, Piramal Enterprises Limited, Light Hall, Chandivali, Powai, Mumbai 400072, India. Electronic address:
    Insights in oral demographics have revealed that a significant percentage of population faces chronic incidences of oral diseases. The innervation of these oral manifestations is required because untreated conditions may lead to bone loss in the oral cavity and systemic complications. Conventional treatments include surgery of the affected area followed by its management and/or treatment with antibiotics. Read More

    Oral paracoccidioidomycosis in a single-center retrospective analysis from a Brazilian southeastern population.
    J Infect Public Health 2017 Nov 16. Epub 2017 Nov 16.
    Department of Clinical Dentistry, Espírito Santo Federal University, Vitória, Brazil. Electronic address:
    Background: Paracoccidioidomycosis (PCM) is the most prevalent endemic systemic fungal infection in Latin America. In Brazil, it stands out as the eighth-highest cause of mortality among chronic or recurrent infections and has the highest mortality rate among systemic mycoses. Oral mucosal lesions may be the first visible physical manifestation of the disease. Read More

    Gastrointestinal and Hepatic Disease in Sjogren Syndrome.
    Rheum Dis Clin North Am 2018 Feb;44(1):143-151
    Rheumatology Division, University of Massachusetts Medical School, 119 Belmont Street, Worcester, MA 01605, USA.
    Sjogren syndrome (SS) is a lymphocyte-mediated, infiltrative autoimmune disorder characterized by destruction of exocrine glands leading to secretory dysfunction. The typical manifestations include xerostomia and xerophthalmia; however, extensive gastrointestinal involvement is increasingly being recognized, emphasizing the variable and systemic nature of SS. Read More

    Oral manifestations of systemic disease.
    Br Dent J 2017 Nov;223(9):683-691
    UCL Eastman Dental Institute, 256 Gray's Inn Road, London, WC1X 8LD.
    While the majority of disorders of the mouth are centred upon the direct action of plaque, the oral tissues can be subject to change or damage as a consequence of disease that predominantly affects other body systems. Such oral manifestations of systemic disease can be highly variable in both frequency and presentation. As lifespan increases and medical care becomes ever more complex and effective it is likely that the numbers of individuals with oral manifestations of systemic disease will continue to rise. Read More

    Oral manifestations of systemic disease.
    Gen Dent 2017 Nov-Dec;65(6):23-29
    On examination, the oral cavity may exhibit manifestations of underlying systemic disease and serve as an indicator of overall health. Systemic diseases with oral findings include autoimmune, hematologic, endocrine, and neoplastic processes. Autoimmune disease may manifest as oral ulcerations, changes in the salivary and parotid glands, and changes in the tongue. Read More

    Oil pulling and importance of traditional medicine in oral health maintenance.
    Int J Health Sci (Qassim) 2017 Sep-Oct;11(4):65-70
    Department of Oral and Maxillofacial Surgery, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
    Dental diseases have detrimental effects on the functionality and quality of life of individuals. In addition, a strong relationship has been established between various oral and systemic diseases. In fact, the prevention and treatment of dental caries and periodontal disease have been shown to reduce the risk of diabetes and heart disease significantly. Read More

    Correlation of mucocutaneous manifestations of HIV-infected patients in an ART center with CD4 counts.
    Indian J Dent Res 2017 Sep-Oct;28(5):549-554
    Department of Oral and Maxillofacial Pathology, Vokkaligara Sangha Dental College, Bengaluru, Karnataka, India.
    Background: As the search for reliable clinical indicators for management of human immunodeficiency virus/AIDS continues, mucocutaneous manifestations of HIV are considered among key clinical indicators for prediction of underlying degree of immunosuppression, systemic opportunistic infections, and disease progression.

    Objectives: (1) To study the prevalence of mucocutaneous manifestations in HIV-seropositive patients attending the ART center of our hospital (2) To correlate mucocutaneous manifestations with CD4 cell counts.

    Materials And Methods: A total of 200 HIV-seropositive patients of adult age group visiting our hospital were included in the study. Read More

    [The role of the human microbiom in the pathogenesis of rheumatoid arthritis - a literature review].
    Wiad Lek 2017;70(4):798-803
    Oddział Reumatologii Miejskiego Szpitala Zespolonego W Olsztynie, Olsztyn, Polska.
    Rheumatoid arthritis is a chronic, progressive, autoimmune disease with numerous articular, extra-articular and systemic manifestations. The cause of rheumatoid arthritis is multifactorial including genetic and environmental factors. Recent advantages in sequencing techniques have allowed the deep characterization of the human microbiota. Read More

    [Changes of serum Krebs von den Lungen-6 levels in interstitial lung disease associated with dermatomyositis and secondary Sjögren's syndrome: a case report].
    Beijing Da Xue Xue Bao Yi Xue Ban 2017 Oct;49(5):910-914
    Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.
    Interstitial lung diseases (ILDs) are a diverse group of pulmonary disorders characterized by various patterns of inflammation and fibrosis in the interstitium of the lung. The underlying pathogenesis of ILDs is complex and associated with multiple rheumatologic conditions, such as systemic sclerosis, rheumatoid arthritis, pollymyositis and dermatomyositis, Sjögren's syndrome, and systemic lupus erythematosus. As the disease progresses, excessive pulmonary fibrosis impairs alveolar gas exchange and damages pulmonary function. Read More

    Hydroxychloroquine desensitization, an effective method to overcome hypersensitivity-a multicenter experience.
    Lupus 2017 Jan 1:961203317735185. Epub 2017 Jan 1.
    2 Clinical Immunology, Angioedema and Allergy Unit, The Zabludowicz Center for Autoimmune Diseases, 26744 Sheba Medical Center, Tel Hashomer , Israel.
    Hydroxychloroquine (HCQ) is widely used to treat autoimmune/rheumatic diseases such as systemic lupus erythematosus (SLE). The immune modulation effects of HCQ have been highlighted as beneficial for maintaining remission of SLE as well as ameliorating skin, joint and other manifestations. Moreover, HCQ exposure for prolonged periods as well as during pregnancy is considered safe, therefore it is recommended for the vast majority of SLE patients. Read More

    Inflammatory bowel disease in chronic granulomatous disease: An emerging problem over a twenty years' experience.
    Pediatr Allergy Immunol 2017 Dec;28(8):801-809
    University Department of Pediatrics, Unit of Immune and Infectious Diseases, Bambino Gesù Children's Hospital IRCCS, University of Rome Tor Vergata, Rome, Italy.
    Background: Chronic granulomatous disease (CGD) is a primary immunodeficiency of phagocytes, characterized by life-threatening infections and hyperinflammation. Due to survival improvement, inflammatory bowel disease (IBD) is becoming increasingly relevant. Here, we report our 20 year experience. Read More

    Disseminated tuberculosis masquerading as a presentation of systemic lupus erythematosus.
    Int J Rheum Dis 2018 Jan 2;21(1):352-355. Epub 2017 Oct 2.
    Department of Rheumatology & Immunology, Singapore General Hospital, Singapore, Singapore.
    Tuberculosis (TB) infection is the endemic in Asia-Pacific region. Miliary TB is a disseminated form which may present similarly as autoimmune conditions. Here we describe a 17-year-old girl who had miliary TB with manifestations mimicking new-onset systemic lupus erythematosus (SLE) including oral ulcers, serositis, cytopenia, proteinuria and raised autoantibody titers. Read More

    Dental Manifestations of Pediatric Bone Disorders.
    Curr Osteoporos Rep 2017 Dec;15(6):588-592
    Department of Pediatric Dentistry, Attending Riley Hospital for Children, Indiana University School of Dentistry, Indianapolis, IN, USA.
    Purpose Of Review: Several bone disorders affecting the skeleton often are manifest in the maxillofacial region. This review presents the most common bone disorders in children and their dental-oral manifestations: fibrous dysplasia, Paget's disease, osteogenesis imperfecta, renal osteodystrophy, hypophosphatasia, and osteoporosis. The specific intraoral characteristics will reviewed in detail. Read More

    Behçet's disease: review with emphasis on dermatological aspects.
    An Bras Dermatol 2017 Jul-Aug;92(4):452-464
    Contact Dermatitis Outpatient Clinic - Dermatology Division at the Hospital das Clínicas - Universidade Federal de Minas Gerais (UFMG) - Belo Horizonte (MG), Brazil.
    Behçet's disease is a systemic vasculitis characterized by attacks of acute inflammation, which can affect almost every vascularized area of the body. There is a close correlation between the geographical distribution of HLA-B51 and its prevalence. In the etiopathogenesis there are indications of genetic susceptibility associated with environmental influence. Read More

    Myd88 is required for disease development in a primary Sjögren's syndrome mouse model.
    J Leukoc Biol 2017 Dec 26;102(6):1411-1420. Epub 2017 Sep 26.
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, New York, USA;
    Sjögren's syndrome (SS) is an autoimmune disease that often results in diminished exocrine gland function. SS patients also experience systemic disease manifestations, including hypergammaglobulinemia and pulmonary and renal pathoses. MyD88 is a ubiquitously expressed adaptor molecule used by all immune cells that is required for IL-1 receptor (IL-1R), IL-18R, and most TLR signaling. Read More

    Mucopolysaccharidosis type I, II and VI and response to enzyme replacement therapy: Results from a single-center case series study.
    Intractable Rare Dis Res 2017 Aug;6(3):183-190
    Genetics Unit of the Pediatrics Department, Children's Institute, University of São Paulo, SP, Brazil.
    Mucopolysaccharidoses (MPS) types I, II and VI are associated with deficiencies in alpha-L-iduronidase, iduronate-2-sulfatase and N-acetylgalactosamine-4-sulfatase, respectively, and generally involve progressive and multi-systemic clinical manifestations. Enzyme replacement therapy (ERT) appears to be reasonably well tolerated. The aim of this study was to examine clinical and diagnostic findings of a series of pediatric and adult MPS patients, and assess the safety and efficacy of ERT in children and adults with MPS type I, II and VI. Read More

    Oral health in diabetic and nondiabetic patients with chronic kidney disease.
    Saudi J Kidney Dis Transpl 2017 Sep-Oct;28(5):1099-1105
    King Saud Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
    The objective of our study is to assess the subjective and objective oral manifestations and salivary pH in diabetic and nondiabetic uremic patients at a nephrology clinic. A total of 194 diabetic and nondiabetic patients with chronic kidney disease (CKD), who were divided into four groups, Group A, B, C, D, and who were attending a nephrology clinic were included in the study. Predialytic unstimulated whole salivary pH was recorded using pH- measuring strips. Read More

    Clinical and pathological significance of cutaneous manifestations in ANCA-associated vasculitides.
    Autoimmun Rev 2017 Nov 14;16(11):1138-1146. Epub 2017 Sep 14.
    Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Electronic address:
    Objectives: Cutaneous manifestations (CM) in ANCA-associated vasculitides (AAV) are frequent, but data on clinical significance and clinical-pathological correlations are lacking.

    Methods: We conducted a multicenter, retrospective study including 1553 AAV patients. Clinical, biological and pathological features have been analyzed, and tissue samples from 46 biopsies were reviewed in a blind manner. Read More

    Etiology, evaluation, and management of xerostomia.
    Clin Dermatol 2017 Sep - Oct;35(5):468-476. Epub 2017 Jun 27.
    Department of Dermatology, University of California, Davis School of Medicine, Sacramento, CA. Electronic address:
    Xerostomia is defined as the complaint of oral dryness. It is a condition that primarily affects older adults and can have a significant negative effect on one's quality of life. Patients with xerostomia often do not have objective signs of hyposalivation. Read More

    Oral manifestations of nutritional disorders.
    Clin Dermatol 2017 Sep - Oct;35(5):441-452. Epub 2017 Jun 27.
    Department of Dermatology, Mayo Clinic, Rochester, MN. Electronic address:
    Nutritional deficiencies occur when body metabolic requirements are not matched by intake and absorption. Reasons for this discrepancy are numerous, but often social, economic, medical, and even psychiatric factors may play a role. Vitamins and minerals are required for appropriate rapid cell turnover of the oral mucosa. Read More

    The Use of Antibiotics in Odontogenic Infections: What Is the Best Choice? A Systematic Review.
    J Oral Maxillofac Surg 2017 Dec 17;75(12):2606.e1-2606.e11. Epub 2017 Aug 17.
    Titular Professor, Oral and Maxillofacial Surgery Residency Program, University Hospital, Federal University of Pelotas, Pelotas, Brazil. Electronic address:
    Purpose: Odontogenic infections are a common problem in dentistry, and their treatment often requires the use of antibiotics besides the removal of the source of infection, which frequently makes it more difficult for clinicians to make a decision regarding the choice of antibiotic. This study aimed to answer the following questions through the Patient, Intervention, Comparison, Outcome (PICO) format: When should antibiotics be used in dental infections (DIs)? Which are the most effective drugs? How long should antibiotics be administered?

    Materials And Methods: This was a systematic review using the PubMed, Scopus, and Cochrane databases without restriction as to the period researched. The variables analyzed in each article were the number of odontogenic infections in each study, type of study, surgical intervention performed, antibiotics administered, statistical differences between groups studied, and patients' evolution after treatment. Read More

    Clinical spectrum and management options in Vogt-Koyanagi-Harada disease.
    Clin Ophthalmol 2017 7;11:1399-1406. Epub 2017 Aug 7.
    Department of Ophthalmology, Osmania Medical College/Sarojini Devi Eye Hospital, Hyderabad, Telangana, India.
    Purpose: The aim of this study was to describe the clinical features, treatment options, and visual outcome of Vogt-Koyanagi-Harada (VKH) disease patients over a 9-year period.

    Method: A retrospective chart analysis of 32 patients with VKH, from January 2007 to December 2015, at a tertiary care government medical college eye hospital in South India.

    Results: A total of 32 patients were diagnosed with VKH. Read More

    Long-term follow-up in primary Sjögren's syndrome reveals differences in clinical presentation between female and male patients.
    Biol Sex Differ 2017 Aug 8;8(1):25. Epub 2017 Aug 8.
    Unit of Experimental Rheumatology, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, SE-171 76, Stockholm, Sweden.
    Background: Despite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune diseases. In the present study, we aimed to investigate differences in the clinical presentation of primary Sjögren's syndrome (pSS) between the sexes and establish whether male sex is associated with a more severe form of long-term pSS.

    Methods: Our study population included 967 patients with pSS (899 females and 68 males) from Scandinavian clinical centers. Read More

    Common Oral Manifestations of Select Systemic Diseases: Anemia, Diabetes Mellitus and HIV.
    J Calif Dent Assoc 2016 Sep;44(9):553-9
    In this article, we discuss several common abnormal signs and symptoms that may be present in the oral cavity initially with or without any systemic symptoms at a typical dental practice. The purpose of this discussion is to increase clinical awareness for establishing differential diagnoses so that patients may obtain appropriate referrals for appropriate medical treatment. Read More

    Numb chin with mandibular pain or masticatory weakness as indicator for systemic malignancy - A case series study.
    J Formos Med Assoc 2017 Nov 17;116(11):897-906. Epub 2017 Jul 17.
    Department of Hemato-Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Background/purpose: Numb chin syndrome (NCS) is a critical sign of systemic malignancy; however it remains largely unknown by clinicians and dentists. The aim of this study was to investigate NCS that is more often associated with metastatic cancers than with benign diseases.

    Methods: Sixteen patients with NCS were diagnosed and treated. Read More

    Generalized Discoid Lupus Erythematosus as the Presenting Sign of Small Cell Lung Carcinoma.
    Skinmed 2017 1;15(3):218-220. Epub 2017 Jun 1.
    Department of Dermatology, Mayo Clinic, Rochester, MN.
    A 46-year-old woman with a 30 pack-year smoking history presented with a worsening eruption on the left cheek that failed to improve with metronidazole gel. The cutaneous eruption spread to most of her face and did not respond to a brief tapering course of prednisone. During the initial evaluation at our institution, approximately 6 weeks after the onset of the cutaneous eruption, the patient had erythematous, crusted plaques on her face and scalp (Figure 1A); they were also present on the V-area of the anterior aspect of the neck and upper region of the chest, the shoulders, and the arms, with isolated lesions on the trunk and legs. Read More

    Oral manifestations of selective IgA-deficiency: review and case-report.
    J Biol Regul Homeost Agents 2017 Apr-Jun;31(2 Suppl 1):113-117
    Department of Surgical and Morphological Sciences, University of Insubria, Ospedale di Circolo Macchi Foundation, Unit of Oral Pathology, Varese, Italy.
    Immunoglobulin A deficiency is the most common primary immunodeficiency defined as decreased serum level of IgA (less than 7 mg/dl) in the presence of normal levels of other immunoglobulin isotypes. Most individuals with IgA deficiency are asymptomatic and identified coincidentally. However, some patients may present with recurrent infections, allergic disorders and autoimmune manifestations, such as diabetes mellitus, Graves disease and celiac disease. Read More

    Skin Manifestations of Inflammatory Bowel Disease.
    Clin Rev Allergy Immunol 2017 Dec;53(3):413-427
    Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
    Inflammatory bowel disease (IBD) with its two main subtypes Crohn's disease and ulcerative colitis is not restricted to the gastrointestinal tract. Indeed, so-called extraintestinal manifestations (EIMs) are frequent and considerably affect morbidity and mortality. The prevalence of EIMs ranges from 6 to 47%. Read More

    Clinical characteristics of acute hepatitis A outbreak in Taiwan, 2015-2016: observations from a tertiary medical center.
    BMC Infect Dis 2017 06 20;17(1):441. Epub 2017 Jun 20.
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5 Fuhsing Street, Kueishan, Taoyuan, 333, Taiwan.
    Background: Acute hepatitis A is a fecal-oral transmitted disease related to inadequate sanitary conditions. In addition to its traditional classification, several outbreaks in the men who have sex with men (MSM) population have resulted in acute hepatitis A being recognized as a sexually transmitted disease. However, few studies have clarified the clinical manifestations in these outbreaks involving the MSM population. Read More

    [Chronic stress and mental disorders in patients with systemic scleroderma: Results of an interdisciplinary study].
    Ter Arkh 2017;89(5):26-32
    Moscow Research Institute of Psychiatry, Branch, V.P. Serbsky Federal Medical Research Center of Psychiatry and Narcology, Ministry of Health of Russia, Moscow, Russia.
    Aim: To analyze of the prevalence of stressful factors and mental disorders (MDs), as well as their clinical psychopathological and clinical psychological characteristics to improve the comprehensive diagnosis and treatment of systemic scleroderma (SSD).

    Subjects And Methods: Examinations were performed in 110 patients (predominantly women (n=97 (88.2%); mean age, 49. Read More

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