1,033,856 results match your criteria Oral Manifestations of Systemic Diseases


A survey of US early childhood caries programs: findings and recommendations.

J Public Health Dent 2018 Dec 14. Epub 2018 Dec 14.

Section of Population Oral Health, Columbia University College of Dental Medicine, New York, NY, USA.

Objectives: To identify and characterize US early childhood caries (ECC) programs.

Methods: A 39 question online survey was fielded to 245 ECC programs identified from the literature and peer programs. The 101 respondents (41 percent response rate) reported their program's geographic reach, type, areas of focus, target populations, approaches, affiliations, providers, goals, costs, and funding. Read More

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December 2018
3 Reads

Children's untreated decay is positively associated with past caries experience and with current salivary loads of mutans Streptococci; negatively with self-reported maternal iron supplements during pregnancy: a multifactorial analysis.

J Public Health Dent 2018 Dec 14. Epub 2018 Dec 14.

Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia.

Objectives: This study explored the association of children's salivary characteristics, past caries experience, birth weight, and reported maternal prenatal vitamin and mineral supplementation with the dental untreated decay of the child.

Methods: This cross-sectional study, a sub-study of Griffith University Environments for Healthy Living birth cohort study, was conducted on 174 mother-child dyads. Mother's prenatal usage of vitamin and mineral supplements; child's birthweight; salivary pH, buffering capacity, and levels of salivary MS and LB were explored as risk indicators. Read More

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December 2018

Ventilator-associated pneumonia: The central role of transcolonization.

J Crit Care 2018 Dec 6;50:155-161. Epub 2018 Dec 6.

Medical and Surgical Intensive Care Unit, Groupe Hospitalier Paris Saint Joseph, Paris, France; Endotoxins, Structures and Host Response, Department of Microbiology, Institute for Integrative Biology of the Cell, UMR 9891 CNRS-CEA-Paris Saclay University, 98190 Gif-sur-Yvette, France. Electronic address:

Ventilator-associated pneumonia remain frequent and serious diseases since they are associated with considerable crude mortality. Pathophysiology is centered on modifications of regional bacterial flora, especially tracheobronchial tree and oropharyngeal sphere. Bacterial migration from an anatomical area to another seems to be the main explanation of these alterations which are called "transcolonization". Read More

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December 2018

Decreased risk of renal impairment in atrial fibrillation patients receiving non-vitamin K antagonist oral anticoagulants: A pooled analysis of randomized controlled trials and real-world studies.

Thromb Res 2018 Dec 6;174:16-23. Epub 2018 Dec 6.

Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.

Background: Patients with warfarin have a potential risk of warfarin-related nephropathy, which could result in the discontinuation of anticoagulation therapy. The question of whether non-vitamin K antagonist oral anticoagulants (NOACs) use is associated with increased risk of renal impairment in atrial fibrillation (AF) patients remains unanswered.

Methods: Studies were systematically searched through Medline, Embase, Cochrane Library databases, and ClinicalTrials. Read More

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December 2018
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Nanostructured lipid carriers: A potential use for skin drug delivery systems.

Pharmacol Rep 2018 Oct 11;71(1):156-166. Epub 2018 Oct 11.

Department of Pharmaceutical Technology, Medical University of Bialystok, Białystok, Poland. Electronic address:

Skin application of pharmaceutical products is one of the methods used for drug administration. The problem of limited drug penetration via topical application makes searching for safe drug carriers that will provide an expected therapeutic effect of utmost importance. Research into safe drug carriers began with liposome structures, paving the way for work with nanocarriers, which currently play a large role as drug vehicles. Read More

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October 2018
2 Reads

An improved rat model for chronic inflammatory bowel disease.

Pharmacol Rep 2018 Oct 11;71(1):149-155. Epub 2018 Oct 11.

School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD, Australia; Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD, Australia. Electronic address:

Background: Inflammatory bowel disease (IBD) is an important cause of chronic disability in humans.

Methods: We characterized a model of chronic IBD in young male Wistar rats by administering dextran sodium sulfate (DSS: 0%, 0.25%, 0. Read More

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October 2018
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Upregulation of the lactate transporter monocarboxylate transporter 1 at the blood-brain barrier in a rat model of attention-deficit/hyperactivity disorder suggests hyperactivity could be a form of self-treatment.

Behav Brain Res 2018 Dec 11. Epub 2018 Dec 11.

The Brain and Muscle Energy Group, Electron Microscopy Laboratory, Department of Oral Biology, University of Oslo, NO-0316 Oslo, Norway; Synaptic Neurochemistry and Amino Acid Transporters Labs, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences (IMB) and Healthy Brain Ageing Centre (SERTA), University of Oslo, NO-0317 Oslo, Norway; Center for Healthy Aging, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

The energy deficit hypothesis of attention-deficit/hyperactivity disorder (ADHD) suggests that low lactate production by brain astrocytes causes the symptoms of the disorder. Astrocytes are the main producers of lactate in the brain; however, skeletal muscles can produce the most lactate in the body. The lactate production by skeletal muscles increases with physical activity, as does the expression of the lactate transporter monocarboxylate transporter 1 (MCT1) at the blood-brain barrier (BBB). Read More

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December 2018

Clinical and aetiological study of hand, foot and mouth disease in southern Vietnam, 2013-2015: inpatients and outpatients.

Int J Infect Dis 2018 Dec 11. Epub 2018 Dec 11.

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Background: Hand, foot and mouth disease (HFMD) has been associated with large outbreaks among young children, including severe illness and fatality, in the Asia-Pacific Region since 1997. Severe illness is often associated with enterovirus A71 (EV-A71). Vietnam experienced a large sustained outbreak of 200. Read More

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December 2018
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Microcontainers for protection of oral vaccines, in vitro and in vivo evaluation.

J Control Release 2018 Dec 11. Epub 2018 Dec 11.

Department of Micro- and Nanotechnology, Technical University of Denmark, Oersteds Plads 345C, 2800 Kgs., Lyngby, Denmark.

Oral vaccines are highly desirable due to simple logistics, mass vaccination potential and for mucosal immunity. Subunit vaccines are preferred due to high safety, but are inherently difficult to deliver orally, thus providing motivation for the use of advanced oral delivery systems. Polymeric devices in micrometer size (microcontainers) were tested here for this purpose. Read More

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December 2018
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Spatiotemporal decomposition and risk determinants of hand, foot and mouth disease in Henan, China.

Sci Total Environ 2018 Dec 5;657:509-516. Epub 2018 Dec 5.

China National Center for Food Safety Risk Assessment, Beijing 100022, China. Electronic address:

Hand, foot and mouth disease (HFMD) remains an increasing public health concern. The spatiotemporal variation of HFMD can be represented from multiple-perspectives, and it may be driven by different dominant factors. In this study, the HFMD cases in children under the age of five years in each county in Henan province, China, from 2009 to 2013 were assessed to explore the integrative spatiotemporal patterns of HFMD and investigate their driving factors. Read More

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December 2018
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A New Model to Predict Ischemic Stroke in Patients with Atrial Fibrillation Using Warfarin or Direct Oral Anticoagulants.

Heart Rhythm 2018 Dec 11. Epub 2018 Dec 11.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.

Background: Stroke risk stratification scores (e.g., CHADS-VASc) are used to tailor therapeutic recommendations for patients with atrial fibrillation (AF) in different risk groups. Read More

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December 2018
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Neonatal exposure to a glyphosate-based herbicide alters the histofunctional differentiation of the ovaries and uterus in lambs.

Mol Cell Endocrinol 2018 Dec 11. Epub 2018 Dec 11.

Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquímica y Ciencias Biológicas, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional del Litoral, Santa Fe, Argentina. Electronic address:

The aim of the present study was to compare the effect of oral and subcutaneous exposure to a glyphosate-based herbicide (GBH) on the female reproductive system, specifically in the ovaries and uterus of prepubertal lambs. To this end, ewe lambs were exposed to a s.c. Read More

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December 2018

The Asthma Controller Step-down Yardstick.

Ann Allergy Asthma Immunol 2018 Dec 11. Epub 2018 Dec 11.

Kaiser Permanente Southern California Region, Department of Allergy and Research and Evaluation, San Diego and Pasadena, CA.

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December 2018
2 Reads

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

Cell 2018 Dec;175(7):1756-1768.e17

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard University Medical School, Boston, MA 02115, USA. Electronic address:

Irisin is secreted by muscle, increases with exercise, and mediates certain favorable effects of physical activity. In particular, irisin has been shown to have beneficial effects in adipose tissues, brain, and bone. However, the skeletal response to exercise is less clear, and the receptor for irisin has not been identified. Read More

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December 2018
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Three-Dimensional Orofacial Changes Occurring After Proportional Condylectomy in Patients With Condylar Hyperplasia Type 1B (Unilateral Hemimandibular Elongation).

J Oral Maxillofac Surg 2018 Nov 20. Epub 2018 Nov 20.

Department Head, Department of Oral and Maxillofacial Surgery, Sheba Medical Center, Tel-Hashomer, Affiliated to Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Purpose: To evaluate 3-dimensional orofacial changes that occurred after proportional condylectomy that was not followed by orthognathic surgery in patients with condylar hyperplasia type 1B (unilateral hemimandibular elongation).

Materials And Methods: This retrospective analysis used the medical records of 14 skeletally mature patients. Transverse, vertical, and horizontal cephalometric analyses of photographs and radiographs were undertaken. Read More

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November 2018
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Impact of material properties and process variables on the residence time distribution in twin screw feeding equipment.

Int J Pharm 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.

Screw feeders are integrated as dispensing units in most continuous manufacturing platforms. Hence, characterizing and modelling the residence time distribution (RTD) of materials in feeders is indispensable to understand the traceability of raw materials from the drum till tablet, enabling the separation of non-confirming material. The proposed methodology addressed this leap in knowledge by characterizing materials, performing RTD trials according to an experimental design, applying RTD models and establishing a partial least square (PLS) regression model that links the material properties and process variables with the RTD responses as outputs. Read More

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December 2018

Socio-demographic determinants as predictors of oral hygiene status and gingivitis in schoolchildren aged 7-12 years old: A cross-sectional study.

PLoS One 2018 14;13(12):e0208886. Epub 2018 Dec 14.

Dental Research Centers, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.

Objective: Gingivitis and poor oral hygiene status are the most prevalent oral diseases among primary school students. Poor oral hygiene status, gingivitis and socio-demographic determinants have been shown to be associated with periodontal diseases. There is limited information on the gingivitis and oral hygiene status among Iranian children. Read More

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December 2018

Phenotypic variability and neuropsychological findings associated with C9orf72 repeat expansions in a Bulgarian dementia cohort.

PLoS One 2018 14;13(12):e0208383. Epub 2018 Dec 14.

Karolinska Institutet, Dept NVS, Division for Neurogeriatrics, Bioclinicum, Akademiska stråket, Solna, Sweden.

Background: The GGGGCC repeat expansion in the C9orf72 gene was recently identified as a major cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in several European populations. The objective of this study was to determine the frequency of C9orf72 repeat expansions in a Bulgarian dementia cohort and to delineate the associated clinical features.

Methods And Findings: PCR-based assessments of the C9orf72 hexanucleotide repeat expansion in all study samples (including 82 FTD, 37 Alzheimer's disease (AD), and 16 other neurodegenerative/dementia disorder cases) were performed. Read More

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December 2018

Impact of a Nutrition-Focused Quality Improvement Intervention on Hospital Length of Stay.

J Nurs Care Qual 2018 Dec 12. Epub 2018 Dec 12.

Clinical Nutrition, Sodexo Healthcare, Gaithersburg, Maryland (Ms Siegel and Mr Higgins); Department of Agricultural Economics, Mississippi State University, Starkville, Mississippi (Dr Fan); Catholic Heath Initiatives, Denver, Colorado (Ms Goldman); and Health Economics and Outcomes Research, Abbott Nutrition Research and Development, Columbus, Ohio (Drs Goates and Partridge).

Background: Despite its high prevalence, malnutrition in hospitalized patients often goes unrecognized and undertreated.

Local Problem: A hospital system sought to improve nutrition care by implementing a quality improvement initiative. Nurses screened patients upon admission using the Malnutrition Screening Tool and initiated oral nutrition supplements for patients at risk. Read More

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December 2018

Third Molar Eruption and Hardware Fungal Infection Following Treatment of Mandibular Angle Fracture.

J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Plastic Surgery, University of Virginia Health System.

Appropriate management of lower 3rd molars is crucial to successful treatment of mandibular angle fractures. A unique case of a patient who presented for initial management of a left mandibular angle fracture with an unerupted lower 3rd molar was discussed in this study. After treatment with open reduction and internal fixation of the fracture, the lower 3rd molar erupted and the patient subsequently developed fungal osteomyelitis and hardware failure. Read More

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December 2018

Radical Surgery for Head and Neck Rhabdomyosarcoma Failed Primary Chemotherapy.

J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Oral and Maxillofacial Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Stomatology, Shanghai, China.

Objective: The aim of the study was to explore an optimal surgery way for head and neck rhabdomyosarcoma (HNRMS) children who have failed primary chemotherapy.

Methods: A total of 51 HNRMS children who have failed primary chemotherapy were retrospectively analyzed from April 2005 to May 2017. Surgery was performed in 2 ways, widely radical resection (22 patients) and conservative resection (29 patients). Read More

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December 2018

Impact of dose capping in insulin glargine/lixisenatide fixed-ratio combination trials in patients with type 2 diabetes.

Curr Med Res Opin 2018 Dec 14:1-21. Epub 2018 Dec 14.

d National Research Institute , Los Angeles , CA , USA .

Objective: The LixiLan clinical trials of insulin glargine (iGlar)/lixisenatide fixed-ratio combination (iGlarLixi) investigated the safety and efficacy of iGlarLixi versus iGlar: LixiLan-O (NCT02058147) in patients with type 2 diabetes (T2D) inadequately controlled on oral antidiabetes drugs (OADs), and LixiLan-L (NCT02058160) in patients with T2D inadequately controlled on basal insulin ± OADs. In these two trials, both iGlar and iGlarLixi were titrated to a maximum (capped) dose of 60 units. We evaluated whether this may have affected the reported glycemic efficacy of iGlar, and the glycemic differences observed between treatment with iGlarLixi and iGlar. Read More

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December 2018

Comparison of a twice-daily injection of insulin aspart 50 with insulin aspart 30 in patients with poorly controlled type 2 diabetes.

Curr Med Res Opin 2018 Dec 14:1-16. Epub 2018 Dec 14.

a Department of Endocrinology , The First Affiliated Hospital of Dalian Medical University , Dalian , PR China.

Objective: To compare the efficacy and safety of a twice-daily injection of insulin aspart (BIAsp) 30 and BIAsp50 in patients with type 2 diabetes mellitus (T2DM) poorly controlled with oral hypoglycaemic agents (OHAs).

Methods: In this 12-week prospective, randomized, parallel trial, a total of 80 T2DM patients, 59 ± 10 years old with a disease duration of 9.3 ± 6. Read More

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December 2018
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Training articulation sequences: A first systematic modulation of the articulatory in-out effect.

J Exp Psychol Learn Mem Cogn 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology.

People prefer words with consonant articulation locations moving inward, from the front to the back of the mouth (e.g., ), over words with consonant articulation locations moving outward, from the back to the front of the mouth (e. Read More

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December 2018
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A Special Risk Group for Hepatitis E Infection: The First Record of North Cyprus.

Pol J Microbiol 2018 ;67(4):525-528

Department of Biophysics, Faculty of Medicine, Near East University , Nicosia , Cyprus.

Hepatitis E virus (HEV) is transmitted by a fecal oral route from animals to humans following exposure to the body fluids of infected animals. We investigated the seroprevalence of anti-hepatitis E (anti-HEV) antibodies by monitoring IgG and IgM virus antibodies amongst employees in the animal industry in North Cyprus through a cross-sectional study. Samples were taken from individuals without occupational exposure to animals and from those who worked with animals (doing animal husbandry, veterinary work or butchery). Read More

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January 2018

[Clinical application of seven-item Eustachian Tube Dysfunction Questionnaire].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1483-1486

Department of Otorhinolaryngology Head and Neck Surgery, Shaanxi Provincial People's Hospital.

To investigate the clinical value of the seven-item Eustachian Tube Dysfunction Questionnaire(ETDQ-7) in evaluating Eustachian tube dysfunction before and after treatment. A retrospective analysis of 50 patients with Eustachian tube dysfunction diagnosed. All the patients were given chymotrypsin 4 000 IU and dexamethasone injection 5 mg by blowing through the Eustachian tube under nasal endoscopic guidance once daily for 3-6 consecutive days. Read More

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October 2018

[Reconstruction of scarring pharyngeal stenosis with forearm free flap:a case report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1434-1435

A 33-year-old man presented with recurrent oral ulcers for more than 10 years,accompanying dyspnea and dysphagia for 1 year and aggravate for 1 month.Physical examination:pharyngeal cavity stenosis,mucous retention, epiglottis was extruded into the infant type. Electronic laryngoscope:Epiglottis curl,bilateral pyriform sinus disappeared. Read More

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September 2018
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[Effect of butylphthalide on oxidative stress and cognitive function in old obstructive sleep apnea hypopnea syndrome patients].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1422-1425

Department of Respiration of North China University of Science and Technology Affiliated Hospital, 063000, China.

To explore the effect of butylphthalide on oxidative stress and cognitive function in old obstructive sleep apnea hypopnea syndrome (OSAHS)patients.A total of 90 old OSAHS patients with cognitive impairment were choosed with Polysomnography(PSG). By random number table method OSAHS patients were randomly divided into non-invasive ventilator group (=30), butylphthalide with non-invasive ventilator group(=30) and treatment group of butylphthalide(=30). Read More

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September 2018

[Preliminary experience of transoral robotic surgery in laryngeal and hypopharyngeal tumors with da Vinci surgical system].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1065-1070

Department of Otolaryngology Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.

The purpose of this study was to summarize preliminary clinical experience of transoral robotic surgery (TORS) in laryngeal and hypopharyngeal tumors with da Vinci surgical system.Twelve patients were reviewed who were diagnosed with laryngeal (=7) and hypopharyngeal tumors (=5) and treated with TORS in Beijing Anzhen Hospital from July 1, 2016 to January 31, 2018.Ten cases were male and two cases were female. Read More

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[Robotic nasopharyngectomy via combined approach of noseand oral for local recurrent nasopharyngeal carcinoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1048-1050;1055

Department of Otolaryngology, Sun Yat-sen Memorial Hospital,Sun Yat-sen University, Guangzhou, 510120, China.

Surgery is one of the salvage treatments for recurrent nasopharyngeal carcinoma. The safety and efficacy of Da Vinci's robotic surgery was preliminarily investigated to resect recurrent nasopharyngeal cancer after one-course radiotherapy.Since Oct 2017, Da Vinci surgery system was used to complete the operation of locally recurrent nasopharyngeal carcinoma including two approaches, such as trans oral with soft palate incision and trans oral and nose with soft palate suspended. Read More

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[Advances in prevention of pharyngocutaneous fistula after total laryngectomy].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1917-1922

Total laryngectomy is a common method for the treatment of malignant tumors of the pharynx and larynx in China, but pharyngocutaneous fistula often happens after surgery, which burdens patients and affects postoperative recovery. At present, there are many measures to prevent pharyngocutaneous fistula, including strengthening nutrition pre-operative and post-operative, testing related indicators, controlling comorbidities, rational use of drugs, regular oral care, optimal selection of incision closure, and using of flaps and special materials during operation, etc. However, the choice of specific program needs to take care of the patient's condition, surgeon's skills and hospital conditions, and often requires multiple programs to be used together throughout the perioperative period. Read More

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December 2018

Salivary creatinine and urea in patients with end-stage chronic kidney disease could not be used as diagnostic biomarkers for the effectiveness of dialysis treatment.

G Ital Nefrol 2018 Dec;35(6)

Department of Oral Surgery, Faculty of Dental medicine, Medical University, Plovdiv, Bulgaria.

Introduction: End-stage chronic kidney disease (CKD) is characterized by kidney failure with the organ's functions reduced or lost completely, where the kidneys are incapable of filtering excess fluids. Renal replacement therapy may be provided by peritoneal dialysis, hemodialysis or renal transplantation. Among the key indicators for tracking patients' current status are urea and creatinine levels. Read More

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December 2018

Heterogeneity of Treatment Effects of Long-Acting Injectable Antipsychotic Medications.

J Clin Psychiatry 2018 Nov 27;80(1). Epub 2018 Nov 27.

Department of Psychiatry and Health Behaviors, Augusta University Health, Augusta, Georgia, USA.

Objective: To investigate subgroup responses to long-acting injectable (LAI) medications haloperidol decanoate (HD) and paliperidone palmitate (PP) in a randomized controlled trial that found no difference between the treatments on the primary outcome of efficacy failure.

Methods: A Comparison of Long-Acting Injectable Medications for Schizophrenia (ACLAIMS) enrolled 311 participants from March 2011 to July 2013 meeting DSM-IV-TR criteria for diagnoses of schizophrenia or schizoaffective disorder at risk of relapse due to medication nonadherence or substance abuse. Participants were randomly assigned to double-blinded treatment with HD or PP and followed for up to 2 years. Read More

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November 2018

Integrated QSAR Models to Predict Acute Oral Systemic Toxicity.

Mol Inform 2018 Dec 14. Epub 2018 Dec 14.

Department of Earth and Environmental Sciences, University of Milano-Bicocca, P.za della Scienza 1, 20126, Milano, Italy.

The ICCVAM Acute Toxicity Workgroup (U.S. Department of Health and Human Services), in collaboration with the U. Read More

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December 2018

Kinetics of indocyanine green: Optimizing tumor to normal tissue fluorescence in image-guided oral cancer surgery applications.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.

Background: The study aimed to define indocyanine green (ICG) kinetics to determine the optimal ICG dose and surgical time for near-infrared fluorescence-guided oral cancer surgery.

Methods: Spectrometer and grayscale digital imaging were used to quantify the ICG kinetics in 12 patients with oral cancer. The fluorescence intensity and signal-to-background ratio (SBR) of tumor and normal tissue were tested at 1, 6, and 24 hours after ICG injection. Read More

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December 2018

Dual Therapy Coating on Micro/Nanoscale Porous Polyetheretherketone to Eradicate Biofilms and Accelerate Bone Tissue Repair.

Macromol Biosci 2018 Dec 14:e1800376. Epub 2018 Dec 14.

School of Chemical Engineering, Sichuan University, Chengdu, 610065, China.

Defective osteogenesis and latent infections continue to be two major issues in the therapy of bone tissue regeneration. In this study, a unique hierarchically micro/nanoscale-architecture is first proposed and produced on polyetheretherketone (PEEK). Besides, a "simvastatin-PLLA film-tobramycin microspheres" delivery system is subsequently fabricated to endow the PEEK implant with osteogenic and antibacterial capabilities. Read More

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December 2018

Factors associated with gastrostomy tube dependence following salvage total laryngectomy with microvascular free tissue transfer.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine, Houston, Texas.

Background: Following salvage total laryngectomy (STL) with microvascular-free tissue transfer (MFTT), patients are at high risk for swallowing dysfunction, but risk factors for persistent gastrostomy tube (G-tube) dependence are unknown.

Methods: Retrospective review of 33 patients who underwent STL with MFTT.

Results: A total oral diet was achieved by 81% of patients with ≥6 months of postoperative follow-up. Read More

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December 2018

Serum matrix metalloproteinase 8 and tissue inhibitor of metalloproteinase 1: Potential markers for malignant transformation of recurrent respiratory papillomatosis and for prognosis of laryngeal cancer.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Biomarkers that could predict malignant transformation of recurrent respiratory papillomatosis (RRP) would be useful in patient follow-up. We investigated whether serum matrix metalloproteinase 8 (MMP-8) and tissue inhibitor of metalloproteinase 1 (TIMP-1) could predict malignant transformation of RRP and whether they associate with survival in laryngeal squamous cell carcinoma (LSCC) without preexisting RRP.

Methods: We analyzed serum MMP-8 (S-MMP-8) and serum TIMP-1 (s-TIMP-1) in 114 patients: 55 were treated for RRP and 59 for LSCC without preexisting RRP. Read More

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December 2018

Role and regulation of proapoptotic Bax in oral squamous cell carcinoma and drug resistance.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Centre for Life Sciences, School of Natural Sciences, Central University of Jharkhand, Ranchi, Jharkhand, India.

Background: Bax, a proapoptotic protein but its regulation during oral cancer progression and resistance remains elusive.

Methods: A total of 127 samples including adjacent normal, primary tumor, and resistance to chemoradiation therapy (RCRT) samples from oral squamous cell carcinoma (OSCC) patients were used. The status of Bax was analyzed at DNA/mRNA/protein levels and the results were correlated with p53 and Akt expression in tissue samples/cisplatin-resistant oral tongue SCC (SCC9/SCC4-CisR) cell line. Read More

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December 2018

Significance of intraparotid node metastasis in predicting local control in primary parotid cancer.

Laryngoscope 2018 Dec 14. Epub 2018 Dec 14.

Department of Oral Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.

Objective: To analyze the metastasis rate in intraglandular lymph nodes (IGLNs) with a focus on discussing the significance of IGLN metastasis in local control (LC) of parotid gland cancer (PGC).

Methods: A total of 337 patients were enrolled. Information including age; sex; and pathologic variables such as tumor (T) stage, IGLN metastasis, and follow-up findings was extracted and analyzed. Read More

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December 2018

Root dentinal microcracks: a post-extraction experimental phenomenon?

Int Endod J 2018 Dec 14. Epub 2018 Dec 14.

School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.

Aim: To investigate the prevalence, location, and pattern of preexisting microcracks in non-endodontically treated teeth from fresh cadavers. Micro-computed tomography (micro-CT) technology was used as the analytical tool enabling full screening of the root dentine with the teeth retained in their original alveolar socket.

Methodology: As a pilot study and to validate the present method, a series of 4 high-resolution scans were performed on one bone-block specimen with teeth collected postmortem: (i) entire bone-block including the teeth, (ii) second molar tooth extracted atraumatically from the bone-block (iii) extracted tooth dehydrated to induce dentinal defects and (iv) entire bone-block following reinsertion of the extracted tooth into its matching alveolar socket. Read More

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December 2018

Angiogenin production in response to hypoxia and l-mimosine in periodontal fibroblasts.

J Periodontol 2018 Dec 14. Epub 2018 Dec 14.

Department of Conservative Dentistry and Periodontology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.

Background: A major mediator of angiogenesis is angiogenin which is expressed in the early phase of healing in oral tissue engineering strategies. It is unclear how angiogenin is regulated in the periodontal tissue. The objective of this study was to reveal the regulation of angiogenin in response to hypoxia and the hypoxia mimetic agent L-mimosine in periodontal fibroblasts METHODS: Human fibroblasts of the periodontal ligament (PDLF) and the gingiva (GF) in monolayer and spheroid cultures were exposed to hypoxia or L-mimosine. Read More

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December 2018

Cytokine, chemokine and growth factor levels in peri-implant sulcus during wound healing and osseointegration after piezosurgical versus conventional implant site preparation: Randomized, controlled, split-mouth trial.

J Periodontol 2018 Dec 14. Epub 2018 Dec 14.

Division of Oral Diseases, Department of Dental Medicine, Karolinska Institute, Stockholm, Sweden.

Aim: To evaluate the cytokine, chemokine and growth factor levels in peri-implant sulcular fluid (PISF) during healing and osseointegration at osteotomy sites prepared either with piezosurgery (PS) or drills.

Materials And Methods: Fourteen patients having contralateral partial edentulism in the posterior maxilla were enrolled and 38 osteotomies were prepared. Implants were placed with one-stage surgery. Read More

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December 2018

Impact of genetic variation on pravastatin systemic exposure in pediatric hypercholesterolemia.

Clin Pharmacol Ther 2018 Dec 14. Epub 2018 Dec 14.

Division of Clinical Pharmacology, Medical Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, MO.

This study investigated the impact of SLCO1B1 genotype on pravastatin systemic exposure in hypercholesterolemic children and adolescents. Participants (8-20 years) with at least one allelic variant of SLCO1B1 c.521T>C (521TC, n=15; 521CC, n=2) and wild type controls (521TT, n=15) completed a single oral dose pharmacokinetic study. Read More

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December 2018

Impact of modified FOLFOX-6 for patients with gastric cancer and a gastrointestinal obstruction.

Asia Pac J Clin Oncol 2018 Dec 13. Epub 2018 Dec 13.

Department of Internal Medicine II, Osaka Medical College, Takatsuki, Osaka, Japan.

Aim: Gastric cancer patients are normally treated with oral fluoropyrimidine and cisplatin or oxaliplatin; however, treating patients who also have a gastrointestinal obstruction is often difficult because of their poor oral intake. Instead, a modified (m)FOLFOX-6 regimen is administered, even to patients with gastrointestinal obstructions. The aim of this study was to assess the efficacy of mFOLFOX-6 for gastric cancer patients with a gastrointestinal obstruction. Read More

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December 2018

Assessing the adoption of lopinavir/ritonavir oral pellets for HIV-positive children in Zimbabwe.

J Int AIDS Soc 2018 Dec;21(12):e25214

AIDS and TB Unit, The Ministry of Health and Child Care, Harare, Zimbabwe.

Introduction: Heat-stable lopinavir/ritonavir (LPV/r) oral pellets were developed to overcome challenges with administration and storage experienced with previously available tablet and syrup forms of LPV/r prescribed to paediatric HIV patients. We report on the adoption of LPV/r pellets for infants living with HIV in the public sector antiretroviral therapy (ART) programme in Zimbabwe.

Methods: Infants aged three months to three years who had been prescribed a LPV/r-based regimen (including ART-naïve patients) in fourteen facilities across the country were eligible to receive the pellets. Read More

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December 2018

Biomaterial-induced multinucleated giant cells express proinflammatory signaling molecules: A histological study in humans.

J Biomed Mater Res A 2018 Dec 13. Epub 2018 Dec 13.

Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, FORM (Frankfurt Orofacial Regenerative Medicine) Lab, University Hospital Frankfurt Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

The biomaterials physicochemical characteristics influence their cellular reaction, degradation and regenerative capacities. Macrophages and multinucleated giant cells (MNGCs) are observed in the augmentation area of biomaterials. This study, for the first time, evaluated the polarization pattern of macrophages and MNGCs in response to two different bone substitute materials (synthetic bone substitute material (SBSM) = NanoBone® vs. Read More

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December 2018
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Epstein-Barr virus and human papillomaviruses as favorable prognostic factors in nasopharyngeal carcinoma: A nationwide study in Finland.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, University of Turku and Turku University Hospital, Turku, Finland.

Background: Nasopharyngeal carcinoma (NPC) is related to Epstein-Barr virus (EBV) in endemic areas; however, the role of viruses in nonendemic countries is unclear. Our nationwide study investigated the prevalence and prognostic significance of EBV and human papillomaviruses (HPVs) in Finnish NPC tumors.

Methods: We analyzed samples from 150 patients diagnosed between 1990 and 2009. Read More

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December 2018

Live single cell mass spectrometry reveals cancer-specific metabolic profiles of circulating tumor cells.

Cancer Sci 2018 Dec 14. Epub 2018 Dec 14.

Department of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute, Tokyo, Japan.

Recently, there has been an increased attention to circulating tumor cells (CTCs) analysis, also known as liquid biopsy, owing to its potential benefits in cancer diagnosis and treatment. CTCs are released from primary tumor lesions into the blood stream and eventually metastasize to distant body organs. However, a major hurdle with CTC analysis is their natural scarcity. Read More

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December 2018

Relationship between oral intake, patient perceived swallowing impairment, and objective videofluoroscopic measures of swallowing in patients with head and neck cancer.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Swallowing Systems Core, Departments of Speech, Language and Hearing Sciences and Neurology, University of Florida, Gainesville, Florida.

Background: We aimed to: (1) examine relationships between the Functional Oral Intake Scale (FOIS), Eating Assessment Tool-10 (EAT-10), and objective measures of swallowing (Modified Barium Swallow Impairment Profile [MBSImP©] and penetration-aspiration scale [PAS]) in patients with head and neck cancer, (2) compare outcomes between oral intake vs tube-dependent patients, and (3) compare outcomes across time points.

Methods: A total of 58 patients with head and neck cancer completed the FOIS, EAT-10, and underwent a standardized videofluoroscopy (VFSS). VFSS were analyzed using the PAS and MBSImP©. Read More

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December 2018
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