2,082 results match your criteria Oral Manifestations of Systemic Diseases


JAK1/2 Inhibitor Baricitinib Improves Skin Fibrosis and Digital Ulcers in Systemic Sclerosis.

Front Med (Lausanne) 2022 6;9:859330. Epub 2022 Jun 6.

Department of Dermatology, Dermatology Hospital, Southern Medical University, Guangzhou, China.

Background: Systemic sclerosis (SSc) is a rare disabling connective tissue disease with few available treatment options. Diffuse cutaneous systemic sclerosis (dcSSc) is associated with high mortality. A previous experiment has shown that JAK2 inhibitor can significantly improve skin fibrosis in bleomycin (BLM)-induced murine model, including reducing dermal thickening and collagen accumulation. Read More

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Oral Chronic Graft-Versus-Host Disease.

Front Oral Health 2022 20;3:903154. Epub 2022 May 20.

Division of Oral Medicine and Dentistry, Brigham and Women's Hospital and Dana Farber Cancer Institute Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, United States.

Chronic oral graft-versus-host disease (cGVHD) is a complex, frequent, and highly impactful complication of allogeneic hematopoietic cell transplantation (alloHCT). It represents the leading cause of morbidity and mortality in long-term alloHCT survivors. cGVHD can affect almost any visceral organ system and commonly affects the skin, eyes and mouth, manifesting with signs and symptoms similar to other known immune-mediated and autoimmune diseases. Read More

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Progressive Familial Intrahepatic Cholestasis Type 2 and Recurrence After Liver Transplantation: A Case Report.

Transplant Proc 2022 Jun 16. Epub 2022 Jun 16.

Brasília Children's Hospital, Brasilia, Federal District, Brazil.

Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a rare autosomal recessive disorder caused by mutations in the ABCB11 gene. Clinical manifestations include cholestasis with low γ-glutamyltransferase (GGT), hepatosplenomegaly, and severe pruritus. Liver transplantation is required for individuals with progressive liver disease or failure of the bypass procedure and has been considered curative. Read More

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Cytomegalovirus as a cause of recurrent corneal endotheliitis in the Canadian population.

Can J Ophthalmol 2022 Jun 16. Epub 2022 Jun 16.

Section of Ophthalmology, University of Calgary, Calgary, Alta.

Objective: To report the clinical manifestations, response to antiviral treatment, and long-term visual outcomes of cytomegalovirus endotheliitis in a Canadian population.

Design: Retrospective case series.

Participants: A total of 9 eyes of 7 patients referred to a cornea subspecialty clinic in a major Canadian centre with corneal endotheliitis. Read More

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Oral manifestations in SARS-CoV-2 infection.

Med Oral Patol Oral Cir Bucal 2022 Jun 19. Epub 2022 Jun 19.

Gazi University, Faculty of Dentistry Department of Periodontology, Ankara Biskek Cad. 82. Sok. Emek-Ankara, Turkey

Background: We aimed to evaluate the prevalence of predisposing factors and oral manifestations in SARS-CoV-2 infection.

Material And Methods: 204 SARS-CoV-2 positive patients were included in the study. Questions regarding the systemic, periodontal health, oral hygiene habits, common symptoms and, oral manifestations of COVID-19 such as oral lesions, and dry mouth were included in the survey. Read More

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Potential Benefits of TNF Targeting Therapy in Blau Syndrome, a NOD2-Associated Systemic Autoinflammatory Granulomatosis.

Front Immunol 2022 27;13:895765. Epub 2022 May 27.

Department of Dermatology, Hyogo Medical University, Nishinomiya, Japan.

Blau syndrome is a systemic autoinflammatory granulomatous disease caused by mutations in the nucleotide-binding oligomerization domain 2 () gene. NOD2 is an intracellular pathogen recognition receptor. Upon binding to muramyl dipeptide (MDP), NOD2 activates the NF-κB pathway, leading to the upregulation of proinflammatory cytokines. Read More

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Prevalence of oral manifestations in patients with lupus erythematosus in a sample of the Egyptian population: a hospital based cross-sectional study.

F1000Res 2021 27;10:969. Epub 2021 Sep 27.

Department of Oral Medicine and Periodontology, Cairo University, Cairo, 11562, Egypt.

Several systemic diseases manifest themselves in the oral cavity. Dentists who are unaware of these lesions will possibly miss them. This cross-sectional study aimed to assess the prevalence of oral manifestations in patients with LE in a sample of the Egyptian population. Read More

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Infantile hepatic hemangiomas: looking backwards and forwards.

Precis Clin Med 2022 Mar 11;5(1):pbac006. Epub 2022 Feb 11.

Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.

Infantile hepatic hemangiomas (IHHs) are common benign tumors seen in the liver of infants. IHHs are true infantile hemangiomas (IHs) and have phases of proliferation and involution parallel to those of cutaneous IHs. The definition and classification of IHH are still confusing in the literature. Read More

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Dengue infection triggered immune mediated necrotizing myopathy in children: a case report and literature review.

Pediatr Rheumatol Online J 2022 Jun 7;20(1):40. Epub 2022 Jun 7.

Division of Paediatric Allergy, Immunology and Rheumatology, Department of Paediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Immune-mediated necrotizing myopathy (IMNM) is a subgroup of idiopathic inflammatory myopathies manifesting with progressive weakness, elevated serum creatine kinase (CK) levels, and necrotizing myopathic features on muscle biopsy. There is a paucity of data on the clinical presentation of IMNM in children. We report a paediatric patient who developed anti-3-hydroxy-3-methylglutaryl-CoA reductase (anti-HMGCR)-positive necrotizing myopathy after recent dengue infection. Read More

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Kikuchi-Fujimoto disease - a case report of a paediatric patient.

ARP Rheumatol 2022 Jan-Mar;1(1):87-92

Unidade de Reumatologia Pediátrica, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal.

Kikuchi-Fujimoto disease is usually a self-limited cause of lymphadenitis. It is a prevalent disease amongst Asian individuals, but rare in other parts of the world. It affects especially young women, with limited cases described in children. Read More

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The Impact of Chronic Kidney Disease on Nutritional Status and Its Possible Relation with Oral Diseases.

Nutrients 2022 May 10;14(10). Epub 2022 May 10.

UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

Several studies have demonstrated a strong relation between periodontal diseases and chronic kidney disease (CKD). The main mechanisms at the base of this link are malnutrition, vitamin dysregulation, especially of B-group vitamins and of C and D vitamins, oxidative stress, metabolic acidosis and low-grade inflammation. In particular, in hemodialysis (HD) adult patients, an impairment of nutritional status has been observed, induced not only by the HD procedures themselves, but also due to numerous CKD-related comorbidities. Read More

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Vitamin D Deficiency in Primary Sjögren's Syndrome: Association with Clinical Manifestations and Immune Activation Markers.

Mediterr J Rheumatol 2022 Mar 31;33(1):106-108. Epub 2022 Mar 31.

Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Vitamin D is an agent involved in bone and mineral homeostasis. It has been recognized as a potent immunomodulator. It has immune-enhancing properties, and it induces immune tolerance. Read More

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Cutaneous manifestations of antineutrophil cytoplasmic antibody-associated vasculitis (AAV): a concise review with emphasis on clinical and histopathologic correlation.

Int J Dermatol 2022 May 22. Epub 2022 May 22.

Departments of Dermatology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) comprises a group of small vessel vasculitides grouped by commonalities of clinical manifestations and ANCA testing. Skin findings are not uncommon, although there is considerable overlap and many times nonspecificity. In general, patients with skin findings tend to have more significant systemic illness, and skin lesions most often develop simultaneously or following onset of systemic symptoms. Read More

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[Oral manifestation of a mantle cell lymphoma - a swelling in the buccal mucosa as the initial manifestation of mantle cell lymphoma: a case report].

Swiss Dent J 2022 May;132(5):343-348

Klinik für Mund-, Kiefer-, Gesichts- und Oralchirurgie, Luzerner Kantonsspital, Luzern, Schweiz.

Lymphomas are malignant neoplasms of mature and immature B-cells, T-cells or NK-cells at various stages of differentiation. They predominantly occur in lymphoid tissues, manifestations in the oral cavity are rare: 3.5% of all oral malignancies are lymphomas. Read More

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Eugenol derivatives with 1,2,3-triazole moieties: Oral treatment of cutaneous leishmaniasis and a quantitative structure-activity relationship model for their leishmanicidal activity.

Exp Parasitol 2022 Jul 5;238:108269. Epub 2022 May 5.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Escola de Ciências da Saúde, Universidade do Grande Rio, Rio de Janeiro, Brazil. Electronic address:

Leishmaniasis is a group of neglected vector-borne tropical diseases caused by protozoan parasites of the genus Leishmania that multiply within phagocytic cells and have a wide range of clinical manifestations. Cutaneous leishmaniasis (CL) is a serious public health that affects more than 98 countries, putting 350 million people at risk. There are no vaccines that have been proven to prevent CL, and the treatment relies on drugs that often have severe side effects, justifying the search for new antileishmanial treatments. Read More

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Multiple miliary osteoma cutis, renal failure and secondary hyperparathyroidism in a geriatric patient.

Gerodontology 2022 Jun;39(2):213-217

Director of Oral and Maxillofacial Radiology, Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.

Introduction: Miliary osteoma cutis (MOC) is a cutaneous disorder that develops in response to an ill-defined process or following acne vulgaris. Most cases present incidentally as small radiographic aggregations of normal bone within the cheeks. Infrequently, MOC has been reported with systemic disease, including renal failure. Read More

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Mucormycosis - The deadly fungus - A case report with dental perspective.

J Family Med Prim Care 2022 Apr 18;11(4):1532-1535. Epub 2022 Mar 18.

Department of Oral Medicine and Radiology, Sri Aurobindo College of Dentistry, Medical Science University (MPMSU), Indore, Madhya Pradesh, India.

Mucormycosis is a fungal infection caused by members of Mucorales and zygomycotic species. These are saprophytes known as Mucormycotina that grow from rotten matter or soils during the decomposition of soil. It has been seen affecting many COVID-19-affected patients recently in India. Read More

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[Clinical analysis of 5 cases of systemic juvenile idiopathic arthritis with coronary artery dilatation].

Zhonghua Er Ke Za Zhi 2022 May;60(5):462-465

Department of Rheumatology, Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China.

To investigate the clinical characteristics of systemic juvenile idiopathic arthritis combined with coronary artery dilatation. A retrospective analysis was performed on the clinical data, including clinical manifestations, blood routine, inflammatory factors, echocardiography, vascular ultrasound and CT angiography, treatment and outcomes, etc, of 5 cases with systemic juvenile idiopathic arthritis combined with coronary artery dilation admitted to Department of Rheumatology in the affiliated Children's Hospital of Capital Institute of Pediatrics from May 2019 to June 2021. There were 2 males and 3 females among 5 cases. Read More

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Porphyromonas gingivalis amount in the tongue biofilm is associated with erosive arthritis in systemic lupus erythematosus.

Lupus 2022 Jul 28;31(8):921-926. Epub 2022 Apr 28.

Department of Oral and Maxillofacial Science, 9311Sapienza University of Rome, Italy.

Background: Several data have demonstrated the occurrence of erosive arthritis in Systemic Lupus Erythematosus (SLE) patients. However, a few studies have focused on the pathogenic mechanisms involved in this feature. The implication of oral pathogens has been proved in Rheumatoid Arthritis: in particular, (), by inducing citrullination, could trigger autoimmune response. Read More

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Extended-release tofacitinib for refractory Behçet disease: A case report.

Medicine (Baltimore) 2022 Apr 15;101(15):e29189. Epub 2022 Apr 15.

Department of Ophthalmology, National Cheng Kung University Hospital, Tainan, Taiwan.

Rationale: Although single-cytokine inhibitors can be considered in treating severe or refractory Behçet disease (BD), these biologic agents are associated with potential therapeutic failure due to the multi-cytokine pathogenesis involving Th1- and Th17-type cytokines with activated Janus kinase/signal transducer and activator of transcription signaling pathways. Notably, there is an increasing trend toward the use of small-molecule targeted drug tofacitinib (TOF), a pan-Janus kinase inhibitor, with immediate-release formulations for treating patients with severe or refractory systemic vasculitis involving different vessel sizes. Despite no reported efficacy of extended-release formulations in refractory BD yet, such a dosage form has pharmacokinetic parameters that are comparable to those of conventional immediate-release formulations. Read More

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Anti-melanoma Differentiation-Associated Gene 5 (Anti-MDA5) Dermatomyositis: A Case Presentation.

Cureus 2022 Mar 12;14(3):e23102. Epub 2022 Mar 12.

Rheumatology, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.

We present a case of anti-melanoma differentiation-associated gene 5 (Anti-MDA5) dermatomyositis (DM) in a 30-year-old female. Anti-MDA5 dermatomyositis, previously termed clinically amyopathic dermatomyositis, was first recognized in 2005. Most cases present with varying combinations of cutaneous and oral ulcerations, palmar papules, respiratory symptoms, and minor muscle involvement (most commonly in the shoulders, upper arms, hips, thighs, and neck). Read More

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COVID-19: Are We Facing Secondary Pellagra Which Cannot Simply Be Cured by Vitamin B3?

Int J Mol Sci 2022 Apr 13;23(8). Epub 2022 Apr 13.

Laboratory for Epigenomics, Division of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia.

Immune response to SARS-CoV-2 and ensuing inflammation pose a huge challenge to the host's nicotinamide adenine dinucleotide (NAD) metabolism. Humans depend on vitamin B3 for biosynthesis of NAD, indispensable for many metabolic and NAD-consuming signaling reactions. The balance between its utilization and resynthesis is vitally important. Read More

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Brown tumor of hyperparathyroidism with multiple lesions.

J Oral Maxillofac Pathol 2022 Feb 28;26(Suppl 1):S111-S115. Epub 2022 Feb 28.

Department of Oral Pathology and Microbiology, GITAM Dental College and Hospital, Visakhapatnam, Andhra Pradesh, India.

Brown tumors are rare focal giant-cell lesions that arise as a direct result of the effect of parathyroid hormone (PTH) on bone tissue in some patients with hyperparathyroidism. Browns tumor is a syndrome associated with an increase in PTH levels by parathyroid glands resulting in hypercalcemia. In the present case report, a 44-year-old female patient presented with a rare case of brown tumor with multiple lesions in the head-and-neck region. Read More

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February 2022

Acute Retinal Necrosis: Clinical Features, Diagnostic Pitfalls, Treatment, and Outcome of an Insidious Disease in Children. Case Report and Review of the Literature.

Front Pediatr 2022 1;10:854325. Epub 2022 Apr 1.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy.

Objective: This study aims to explore clinical features, diagnostic work-up, treatment, and outcomes of pediatric patients with acute retinal necrosis (ARN), and to propose a standardized management of this condition in childhood.

Methods: Clinical manifestations, diagnostic work-up, and treatment of three pediatric cases with ARN were analyzed. Furthermore, a review of the literature was performed from January 1990 to November 2021, focused on 1) clinical presentation; 2) differential diagnosis, including both infectious and non-infectious conditions; 3) key role of diagnostic techniques; and 4) currently available treatments. Read More

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Atypical Debut of Granulomatosis with Polyangiitis as Acute Tonsilitis and Strawberry Gum: A Case Report.

Curr Rheumatol Rev 2022 Apr 13. Epub 2022 Apr 13.

Rheumatology Department, Complejo Asistencial Universitario de León (León, Spain).

Background: Granulomatosis with Polyangiitis (GPA) is a systemic necrotizing vasculitis, characterized by necrosis, granulomatous inflammation, and vasculitis. It is characterized by the triad of the upper and lower respiratory system, lung, and kidney disease. Although it is usually a multisystemic disease, limited forms have also been described and otolaryngological involvement is the first manifestation in up to 80-95%. Read More

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Atypical Imaging Findings in "Central Nervous System Varicella Zoster Virus Vasculopathy Sine Herpete".

Neurohospitalist 2022 Apr 11;12(2):404-407. Epub 2022 Feb 11.

Department of Neurology, Neurological Institute (NI), Cleveland Clinic Abu Dhabi (CCAD), Abu Dhabi, United Arab Emirates.

Varicella-zoster virus (VZV) infection is notorious for central nervous system involvement, the spectrum of which encompasses vasculopathic manifestations as well. Central nervous system VZV vasculopathy (CVV) most commonly manifests as ischemic strokes or TIA, even though other less common modes of presentation are also well documented in the literature. The pathophysiological mechanism is primarily attributed to active virus infection in the blood vessels secondary to decline in varicella-specific cell-mediated immunity. Read More

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Oral manifestations of Chediak-Higashi syndrome: A systematic review.

Dis Mon 2022 Apr 9:101356. Epub 2022 Apr 9.

Department of Oral and Maxillofacial Pathology, School of Dentistry, Universidade de Pernambuco, Recife, Pernambuco, Brazil. Electronic address:

Chediak-Higashi syndrome (CHS) is an autosomal recessive disorder characterized by leukocytes with giant secretory granules and a myriad of clinical features. However, it is unknown whether oral lesions are part of the syndrome or are refractory to systemic treatment. Herein, we integrated the available data published in the literature on the oral manifestations of individuals with CHS. Read More

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Aseptic Meningitis in Oral Medicine: Exploring the Key Elements for a Challenging Diagnosis: A Review of the Literature and Two Case Reports.

Int J Environ Res Public Health 2022 03 25;19(7). Epub 2022 Mar 25.

Oral Medicine Unit, Department of Neurosciences, Reproductive and Oral Sciences, "Federico II" University of Naples, 80131 Naples, Italy.

Aseptic meningitis (AM) is a potentially severe and life-threatening disease characterized by meningeal inflammation, usually with mononuclear pleocytosis. It represents a challenging and controversial issue in medicine for multiple etiologies, classification, and difficult diagnosis in the face of nonspecific sets of signs and symptoms. In the area of interest of oral medicine, in specific clusters of patients, even if rare, the occurrence of aseptic meningitis can pose a diagnostic and management dilemma in the following potential etiologies: (i) systemic diseases with oral and meningeal involvement, which include Behçet's disease and Sjögren syndrome; (ii) drug-induced aseptic meningitis; (iii) aseptic viral meningitis, mostly related to herpes simplex virus infection and hand, foot, and mouth disease, caused by enteroviruses. Read More

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Limited cutaneous systemic sclerosis: Total rehabilitation with fixed prosthesis on dental implants.

J Scleroderma Relat Disord 2021 Oct 1;6(3):299-305. Epub 2021 Apr 1.

Universidad Nacional de Córdoba, Córdoba, Argentina.

Introduction: Limited cutaneous systemic sclerosis with special manifestations (calcinosis cutis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) is part of the group of connective tissue diseases, these rare autoimmune systemic pathologies cause thickening and hardening of tissues in different parts of the body and can lead to complex disorders. Oral manifestations of systemic sclerosis may include limited ability to open the mouth, xerostomia, periodontal disease, enlarged periodontal ligament, and bone resorption of the jaw.

Case Description: A 54-year-old Caucasian patient presented with oral pain, swallowing, phonation and chewing difficulties associated with dental instability, hygiene/handling difficulties and her main problem with microstomia, which prevented her from removing the skeletal prosthesis for 4 years, depriving her of social life. Read More

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October 2021

The Diagnostic Dilemma of Acute Granulomatous Hepatitis in a Patient With Crohn's Disease: A Case Report and Review of Literature.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096211069764

Woodhull Medical Center, Brooklyn, NY, USA.

Liver involvement is not an uncommon extraintestinal manifestation of inflammatory bowel disease (IBD). IBD-associated liver diseases may have a variety of etiopathogenetic origins (including shared autoimmune pathogenesis, the effect of chronic inflammatory status, and adverse effects of drugs). Nevertheless, acute granulomatous hepatitis in the setting of Crohn's disease (CD) is a rare clinical entity. Read More

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