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Ceska Gynekol 2022 ;87(2):146-148

Iron deficiency is a common but underestimated condition in the population. Its correlate is far from only sideropenic anemia, but is due to the variety of involvement of this element in a number of bio-chemical reactions; several other possible clinical manifestations can be expected. Appropriately selected oral supplementation is often necessary. Read More

Cureus 2022 May 1;14(5):e24649. Epub 2022 May 1.

Anatomic Pathology, King Faisal Specialist Hospital and Research Centre, Jeddah, SAU.

Morbilliform eruption typically implies a maculopapular rash of acute onset. Drugs are the predominant cause of this cutaneous reaction in adults, followed by infectious exanthems and some rheumatological diseases. In this article, we report on the clinical and histopathological features of generalized pruritic morbilliform eruption in a 28-year-old female following her second dose of Oxford/AstraZeneca COVID-19 vaccine. Read More

J Stomatol Oral Maxillofac Surg 2022 May 23. Epub 2022 May 23.

Department of stomatology and maxillofacial surgery, AP-HP, DHU FAST, GH Pitié- Salpêtrière- Charles Foix, Paris F-75013, France. Electronic address:

Oral manifestations occur at all stages of human immunodeficiency virus (HIV) infection. Their clinical expressions and severity depend on the evolution of the infection and become critical at the stage of acquired immunodeficiency (AIDS). They are essentially infectious, tumoral, and, starting a few years ago, iatrogenic. Read More

Int J Mol Sci 2022 Apr 13;23(8). Epub 2022 Apr 13.

Laboratory for Epigenomics, Division of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia.

Immune response to SARS-CoV-2 and ensuing inflammation pose a huge challenge to the host's nicotinamide adenine dinucleotide (NAD) metabolism. Humans depend on vitamin B3 for biosynthesis of NAD, indispensable for many metabolic and NAD-consuming signaling reactions. The balance between its utilization and resynthesis is vitally important. Read More

Int J Mol Sci 2022 Apr 9;23(8). Epub 2022 Apr 9.

Department of Neurology, School of Medicine, Technical University Munich, Klinikum Rechts der Isar, Ismaninger Str. 22, 81675 Muenchen, Germany.

Neuromyelitis optica spectrum disorders (NMOSD) are rare neurologic autoimmune diseases that have a poor prognosis if left untreated. For many years, generic oral immunosuppressants and repurposed monoclonal antibodies that target the interleukin-6 pathway or B cells were the mainstays of drug treatment. Recently, these drug treatments have been complemented by new biologics developed and approved specifically for NMOSD. Read More

Medicine (Baltimore) 2022 Mar 11;101(10):e28997. Epub 2022 Mar 11.

Division of Nephrology, Department of Internal Medicine, Keimyung University School of Medicine, Keimyung University Dongsan Hospital, Daegu, Republic of Korea.

Rationale: The Chaga mushroom (Hymenochaetaceae, Inonotus obliquus) is a fungus belonging to the Hymenochaetaceae family. It is parasitic on birch and other tree species. Chaga mushrooms are rich in various vitamins, minerals, and nutrients. Read More

BMC Oral Health 2022 03 24;22(1):90. Epub 2022 Mar 24.

Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Bari, Italy.

Background: The 2019 Coronavirus disease (Covid-19) has affected thousands of people worldwide. To date, vaccines appear to be the only method to prevent and reduce mortality. Four vaccinations have been outwardly approved by European Medicine Agency (EMA) in Europe: BNT162b2 (Comirnaty-BioNTech/Pfizer), mRNA-1273 (Spikevax-Moderna), ChAdOx1 (VaxzevriaAstrazeneca), and Ad26. Read More

BMC Gastroenterol 2022 Feb 5;22(1):49. Epub 2022 Feb 5.

Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic.

Background: Sunitinib and pazopanib are both oral small molecule multityrosine kinase inhibitors (MTKI) used in the treatment of renal cell carcinoma (RCC). Hepatotoxicity or "liver injury" is the most important adverse effect of pazopanib administration, but little is known about the underlying mechanism. Liver injury may also occur in patients treated with sunitinib, but severe toxicity is extremely rare. Read More

Cutan Ocul Toxicol 2022 Mar 20;41(1):73-90. Epub 2022 Feb 20.

Faculty of Pharmaceutical Sciences, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.

Introduction: The therapeutic use of humanised monoclonal programmed cell death 1 (PD-1) (pembrolizumab, and nivolumab) and programmed cell death ligand-1 (PD-L1) (atezolizumab, avelumab, durvalumab) immune checkpoint inhibitors (ICPi) as potent anticancer therapies is rapidly increasing. The mechanism of signalling of anti-PD-1/PD-L1 involves triggering cytotoxic CD4+/CD8 + T cell activation and subsequent abolition of cancer cells which induces specific immunologic adverse events that are specific to these therapies. These drugs can cause numerous cutaneous reactions and are characterized as the most frequent immune-related adverse events (irAEs). Read More

J Ethnopharmacol 2022 May 25;290:115032. Epub 2022 Jan 25.

Technical Center for Drug Research and Evaluation of China Association of Traditional Chinese Medicine, 100700, Beijing, China.

Ethnopharmacological Relevance: Shugan granule is derived from Xiaoyao powder, a traditional Chinese medicine that has been shown to be effective in treating emotional disorders. At present, there is no standard drug treatment for mixed anxiety-depressive disorder (MADD), and no evidence-based clinical trial has been performed for any drug, meaning MADD patients are unable to obtain standardized treatment.

Aim Of The Study: The purpose of this clinical trial was to test the clinical efficacy and safety of Shugan granules in the treatment of MADD, and to provide clinical trial-based support along with drug recommendations for the treatment of MADD. Read More

J Cosmet Dermatol 2022 Jan 21. Epub 2022 Jan 21.

Department of Medical Pharmacology, Medical Faculty, Biruni University, Istanbul, Turkey.

Drug-induced angioedema often affects elderly patients with chronic drug use. Proper diagnosis and prompt with effective treatment reduce mortality. With the increasing use of favipiravir, many side effects, especially increased alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels due to liver toxicity, and also skin lesions are reported. Read More

Asian Pac J Allergy Immunol 2021 Dec 26. Epub 2021 Dec 26.

Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Cutaneous manifestations of chronic spontaneous urticaria (CSU) are identical to type 1 hypersensitivity reactions. The daily occurrence of rash from occupational allergy could be misinterpreted as CSU exacerbation.

Objective: We aim to report a nurse with concomitant CSU suffering from latex-induced anaphylaxis. Read More

Contact Dermatitis 2022 Mar 27;86(3):145-164. Epub 2021 Dec 27.

Dermatologist np, Wapserveen, The Netherlands.

The literature on systemic allergic dermatitis (SAD; also known as systemic contact dermatitis) is reviewed. Both topical drugs (from absorption through mucosae or skin) and systemic drugs (oral, parenteral, rectal) may be responsible for the disorder. The topical route appears to be rare with 41 culprit topical drugs found to cause SAD in 95 patients. Read More

Medicine (Baltimore) 2021 Nov;100(45):e27736

The Affiliated Wuxi Mental Health Center of Nanjing Medical University, Department of Psychiatry, Binhu District, Wuxi City, Jiangsu Province, China.

Rationale: Liver function monitoring is recommended when agomelatine is prescribed, although liver enzymes are not considered predictive biomarkers. Most patients present with acute liver injury, with only a few presenting with levels of liver enzymes that are over 30 times the upper limit of normal. The patient-specific risk factors that are associated with liver injury remain unclear. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2022 03 20;133(3):326-332. Epub 2021 Sep 20.

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China. Electronic address:

Objective: The objective of this study was to investigate the clinical manifestations and pathologic appearances of the submandibular gland (SMG) in Stevens-Johnson syndrome (SJS).

Study Design: Patients with autologous transplantation of SMG for treatment of severe dry eye between March 1998 and May 2018 were divided into the SJS group (70 cases) and non-SJS group (50 cases) according to the history of SJS. The SMG weight and computed tomography volume and salivary flow rate were measured. Read More

J AAPOS 2021 12 20;25(6):348.e1-348.e6. Epub 2021 Oct 20.

Department of Ophthalmology, Northwell Health, Great Neck, New York.

Purpose: To identify ophthalmic manifestations of Mycoplasma-induced rash and mucositis (MIRM).

Methods: The medical records of patients with MIRM treated by the inpatient ophthalmology consult service at a single institution over a period of 4 years were reviewed retrospectively. Eye and skin findings, treatment, hospital course, and follow-up findings were documented and reviewed. Read More

J Pediatr Pharmacol Ther 2021 24;26(7):669-674. Epub 2021 Sep 24.

Peanut () Allergen Powder-dnfp (Palforzia, Aimmune™ Therapeutics, Inc.; Brisbane, CA) is the first FDA-approved oral immunotherapy indicated for the mitigation of allergic reactions, including anaphylaxis, in patients with peanut allergy. It may be initiated in individuals 4 to 17 years of age and continued for maintenance in those 4 years of age and older. Read More

Medicine (Baltimore) 2021 Sep;100(36):e27086

Guangzhou Red Cross Hospital, Guangzhou, Guangdong Province, China.

Background: Knee osteoarthritis (KOA) is a chronic degenerative joint disease, which is the most common type of osteoarthritis. The clinical manifestations are pain, swelling, and dysfunction of the knee joint, which seriously reduces the quality of life of patients and causes a huge social burden. At present, western medicine mainly focuses on symptomatic treatment, such as anti-inflammatory and pain relief, joint cavity injection, joint replacement, etc. Read More

Int J Clin Pharmacol Ther 2021 Dec;59(12):775-779

Background: Fluoropyrimidines 5-fluorouracil (5-FU) and capecitabine are antimetabolite drugs used for the treatment of colorectal, breast, head, and neck malignancies. Different clinical manifestations of fluoropyrimidine-induced cardiotoxicity (FIC) have been reported in the literature.

Case Report: A 46-year-old female patient with a history of colorectal adenocarcinoma presented to the Emergency Department due to chest pain and mildly elevated cardiac serum troponin levels. Read More

BMC Endocr Disord 2021 Sep 3;21(1):179. Epub 2021 Sep 3.

Department of Endocrinology, The Second Affiliated Hospital of Xiamen Medical College, 361021, Xiamen, Fujian, China.

Background: Rash and cholestatic liver injury caused by methimazole (MMI) in patients with Turner syndrome (TS) and Graves's disease (GD) are rarely reported, and there is a paucity of reports on the management of this condition. It is not clear whether propylthiouracil (PTU) can be used as a safe alternative in this case.

Case Presentation: A 37-year-old woman was admitted to our hospital with rash, severe pruritus and a change in urine colour after 2 months of GD treatment with MMI. Read More

J Cosmet Dermatol 2022 May 1;21(5):2200-2204. Epub 2021 Aug 1.

Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) refers to an uncommon cutaneous adverse reaction that symmetrically involves the buttock and intertriginous areas after systemic exposure to the offending drug and is previously known as baboon syndrome. SDRIFE related with traditional Chinese medicine (TCM) has not been reported.

Objective: We presented a case of SDRIFE /baboon syndrome induced by TCM, Xi-Huang capsule. Read More

Front Immunol 2021 12;12:609615. Epub 2021 Jul 12.

Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, China.

Background: Rosacea, a chronic inflammatory skin disorder etiologically associated with immune cells and the antibacterial peptide cathelicidin LL-37, can be effectively treated by oral carvedilol administration.

Objective: To investigate the molecular mechanisms underlying carvedilol efficacy in rosacea treatment.

Methods: Skin samples of patients with rosacea were subjected to histopathological (hematoxylin and eosin) and immunohistochemical (CD68, Toll-like receptor 2 (TLR2), kallikrein 5, cathelicidin, TNF-α, and IL-1β) evaluation. Read More

World J Clin Cases 2021 Jul;9(19):4990-4997

Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang 330100, Jiangxi Province, China.

Coronavirus disease 2019 (COVID-19), caused by the infection of a novel coronavirus [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)], has become a pandemic. The infection has resulted in about one hundred million COVID-19 cases and millions of deaths. Although SARS-CoV-2 mainly spreads through the air and impairs the function of the respiratory system, it also attacks the gastrointestinal epithelial cells through the same receptor, angiotensin converting enzyme 2 receptor, which results in gastroenteric symptoms and potential fecal-oral transmission. Read More

Heart Fail Rev 2022 03 16;27(2):517-524. Epub 2021 Jul 16.

Division of Cardiology At Mount Sinai Medical Center, Columbia University, 4300 Alton Rd, Miami Beach, FL, 33140, USA.

Transthyretin cardiac amyloidosis (ATTR-CM) is caused by the accumulation of misfolded transthyretin (TTR) protein in the myocardium. Diflunisal, an agent that stabilizes TTR, has been used as an off-label therapeutic for ATTR-CM. Given limited data surrounding the use of diflunisal, a systematic review of the literature is warranted. Read More

Oral Dis 2022 Jan 3;28(1):9-22. Epub 2021 Aug 3.

Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.

Immunotherapy with immune checkpoint inhibitors (ICIs) has transformed cancer treatment over the past decade, improving survival rates in numerous advanced cancers. Immune-related adverse events (irAEs) are common and can affect any organ system, with many of these toxicities being well-characterized with clear grading criteria and management approaches. There has been less emphasis on oral manifestations of irAEs. Read More

Zhonghua Jie He He Hu Xi Za Zhi 2021 Jul;44(7):611-618

Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, State Key Laboratory of Respiratory Diseases, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

To observe the effectiveness, safety and management of omalizumab therapy for moderate to severe asthma in real-world clinical practice in China. This retrospective analysis involved 79 patients with moderate to severe asthma who received omalizumab therapy for at least 4 months in the First Affiliated Hospital of Guangzhou Medical University from March 2018 to April 2020. All participants were between 14 to 76 years old(median 50 years),including 30 males and 49 females. Read More

Clin Med Insights Case Rep 2021 27;14:11795476211005821. Epub 2021 Mar 27.

Pulmonary Department of NHS, General Hospital "George Papanikolaou," Thessaloniki, Greece.

Introduction: Drug-induced diffuse alveolar hemorrhage (DAH) has been associated with the administration of various medications, among which levonorgestrel (LN) has not been reported until now.

Case Presentation: This case study describes a 42-year-old woman who presented with hemoptysis, hypoxemia, and radiological depiction of ground glass opacities, 3 days after she had received emergency contraceptive medication containing levonorgestrel. Emergent bronchoscopy was performed, and BAL was diagnostic of diffuse alveolar hemorrhage (DAH). Read More

J Dermatol Sci 2021 Aug 11;103(2):124-127. Epub 2021 Jun 11.

Department of Dermatology, Kochi Medical School, Kochi University, Kochi, Japan. Electronic address:

J Oncol Pharm Pract 2022 Jan 24;28(1):250-254. Epub 2021 Jun 24.

Department of Oncology, Lourdes Hospital, Kochi, India.

Introduction: Steven-Johnson syndrome (SJS) is a serious mucocutaneous reaction, characterized by fever, influenza-like symptoms and followed by dermatological manifestations. Capecitabine is an oral fluoropyrimidine carbamate analogue of 5-Fluorouracil (5-FU). It is widely accepted for many malignancies because of its better safety profile and tolerability. Read More

Medicine (Baltimore) 2021 Apr;100(17):e22387

Department of Prosthetic Dentistry, College of Dentistry, King Khalid University, Abha, Kingdom of Saudi Arabia.

Introduction: Drug induced oral erythema multiforme a rare clinical entity which involves only the lips and oral mucosa without skin involvement. These lesions are difficult in diagnosing with other oral ulcerative lesions with similar clinical manifestations.

Patient Concerns: This article presents 2 case reports of Oral erythema multiforme in which drugs were the precipitating factor. Read More