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Medicine (Baltimore) 2021 Apr;100(17):e22387

Department of Prosthetic Dentistry, College of Dentistry, King Khalid University, Abha, Kingdom of Saudi Arabia.

Introduction: Drug induced oral erythema multiforme a rare clinical entity which involves only the lips and oral mucosa without skin involvement. These lesions are difficult in diagnosing with other oral ulcerative lesions with similar clinical manifestations.

Patient Concerns: This article presents 2 case reports of Oral erythema multiforme in which drugs were the precipitating factor. Read More

Praxis (Bern 1994) 2021 Apr;110(6):299-300

Innere Medizin, Kantonsspital Graubünden, Chur.

Lyme disease is the most common vector-borne illness in Switzerland and Lyme arthritis the most prevalent manifestation of late-stage Lyme disease. It presents as a monoarthitis or oligoarthritis in large joints, often involving the knee. Such a clinical presentation, together with positive Lyme serologies or polymerase chain reactions from synovial fluid/tissue, is considered diagnostic. Read More

Praxis (Bern 1994) 2021 Apr;110(5):231-236

Innere Medizin, Kantonsspital Graubünden, Chur.

CME: Musculoskeletal Manifestations of Lyme Disease Lyme disease is the most common vector-borne illness in Switzerland and Lyme arthritis the most prevalent manifestation of late-stage Lyme disease. It presents as a monoarthitis or oligoarthritis in large joints, often involving the knee. Such a clinical presentation, together with positive Lyme serologies or polymerase chain reactions from synovial fluid/tissue, is considered diagnostic. Read More

Dent Clin North Am 2021 Apr 22;65(2):323-343. Epub 2021 Jan 22.

University of Florida Health Science Center Libraries, 1600 Southwest Archer Road, PO Box 100206, Gainesville, FL 32610, USA.

Over the next several decades, rates of aged populations will increase rapidly. These populations are susceptible to multimorbidities and polypharmacy (concurrently, prescribed 5 or more medications). Many medications have side effects that manifest orally. Read More

PLoS One 2021 4;16(2):e0246291. Epub 2021 Feb 4.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chonnam National University Hospital, Gwangju, South Korea.

Objective: This study aimed to evaluate hypersensitivity reactions to anti-tuberculosis (TB) drugs.

Methods: We retrospectively compared the clinical manifestations and treatment outcomes of single and multiple drug hypersensitivity reactions (DHRs).

Results: Twenty-eight patients were diagnosed with anti-TB DHRs using oral drug provocation tests. Read More

Front Med (Lausanne) 2020 14;7:571214. Epub 2021 Jan 14.

Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.

Different viral agents, such as herpesviruses, human papillomavirus, and Coxsackie virus, are responsible for primary oral lesions, while other viruses, such as human immunodeficiency virus, affect the oral cavity due to immune system weakness. Interestingly, it has been reported that coronavirus disease 2019 (COVID-19) patients can show cutaneous manifestations, including the oral cavity. However, the association between oral injuries and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is still unclear. Read More

J Clin Pharm Ther 2021 Jun 6;46(3):705-710. Epub 2021 Jan 6.

Shandong Provincial Hospital Affiliated to Shandong first Medical University, Jinan, China.

What Is Known And Objective: In recent years, the resistance of Mycoplasma pneumoniae to macrolide antibiotics has increased significantly. The health systems are facing significant challenges in carrying out the diagnosis and treatment of refractory Mycoplasma pneumoniae pneumonia in children. Levofloxacin is suitable for treating infectious diseases in various systems but limited in children due to arthropathy issues in weight-bearing joints. Read More

Sci Rep 2020 12 17;10(1):22176. Epub 2020 Dec 17.

Department of Gastroenterology, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama, Saitama, 330-8503, Japan.

Mesalazine is a key drug used for remission induction and maintenance therapy in inflammatory bowel disease (IBD). We sometimes encounter patients who develop allergic reactions to the drug and inevitably discontinue treatment. Of 692 patients who received mesalazine for IBD between 2014 and March 2020, 33 diagnosed with mesalazine allergy (43 episodes) were included, and their clinical manifestations were evaluated. Read More

Am Fam Physician 2020 11;102(10):613-621

University of Texas School of Dentistry at Houston, Houston, TX, USA.

Drugs are being prescribed with more frequency and in higher quantities. A serious adverse drug event from prescribed medications constitutes 2.4% to 16. Read More

Biomed Pharmacother 2020 Nov 17;131:110736. Epub 2020 Sep 17.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.

Bruton tyrosine kinase (BTK) sits at the crossroads of adaptive and innate immunities. Nevertheless, the detailed role of BTK activation in hepatic inflammatory disorders is still elusive to date. Accordingly, we investigated the impact of blocking BTK activation by acalabrutinib (ACB) on lipopolysaccharide/galactosamine (LPS/D-GaIN)-induced deleterious manifestations in the liver. Read More

Signal Transduct Target Ther 2020 11 2;5(1):256. Epub 2020 Nov 2.

Department of Musculoskeletal Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.

Coronavirus disease-2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection is spreading globally and poses a huge threat to human health. Besides common respiratory symptoms, some patients with COVID-19 experience gastrointestinal symptoms, such as diarrhea, nausea, vomiting, and loss of appetite. Read More

Pol Merkur Lekarski 2020 Oct;48(287):349-353

Jagiellonian University Medical College, Department of Gastrology and Hepatology, Krakow, Poland.

Crohn's disease (CD) is a chronic and granulomatous inflammatory disease of the entire gastrointestinal tract. The etiopathogenesis is not fully elucidated. The most common symptoms in the active phase of the disease include abdominal pain, prolonged diarrhea, fever, fatigue, malaise and weight loss. Read More

Indian J Sex Transm Dis AIDS 2020 Jan-Jun;41(1):47-52. Epub 2018 Apr 11.

Department of Dermatology, JSS Hospital, Mysore, Karnataka, India.

Introduction: HIV is associated with various mucocutaneous manifestations which may be the first pointers toward HIV and can also be prognostic markers for disease progression. This study was done to note the different mucocutaneous lesions present in HIV and their relation to total lymphocyte count (TLC).

Methodology: Three hundred and seventy-nine HIV patients attending the Department of Dermatology, Venereology, and Leprosy were included in the study. Read More

Curr Opin Ophthalmol 2020 Nov;31(6):514-520

Department of Ophthalmology, Kasturba Medical College-Manipal, Manipal Academy of Higher Education, Manipal, India.

Purpose Of Review: Ocular manifestations of leprosy do occur despite advances in the areas of leprosy research. Understanding the nuances in the domain shall guide the clinician for effective patient-centered care.

Recent Findings: Despite the existence of microbiologic cure for leprosy, ocular manifestations of this disease do occur. Read More

Postepy Dermatol Alergol 2020 Aug 14;37(4):579-583. Epub 2019 Oct 14.

Department of Cardiology and Internal Diseases, Military Institute of Medicine, Warsaw, Poland.

Introduction: It is known that the administration of the drug during the oral aspirin challenge (OAC) can cause hypersensitivity symptoms not only from the respiratory system or skin, but also from the cardiovascular system.

Aim: To assess the occurrence and nature of cardiovascular adverse events during the OAC in patients suspected of hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs).

Material And Methods: The study included 52 patients with symptoms of hypersensitivity to aspirin (ASA) or other NSAIDs in the form of skin reactions or respiratory response in anamnesis. Read More

Dermatopathology (Basel) 2020 Aug 12;7(2):18-25. Epub 2020 Aug 12.

Unit of Oral Medicine and Pathology, Division of Oral Maxillofacial Surgery, Department of Surgery, University Hospitals of Geneva, 1205 Geneva, Switzerland.

: Lichen planus is a chronic mucocutaneous inflammatory disease. Oral manifestations are common, and may remain exclusive to the oral mucosa without involvement of the skin or other mucosae. A differential diagnosis includes oral lichenoid drug reactions. Read More

Hosp Pharm 2020 Aug 27;55(4):224-235. Epub 2019 Mar 27.

St. Joseph's Health, Syracuse, NY, USA.

Respiratory syncytial virus (RSV)-associated lower respiratory tract infection (LRTI) is a concern in immunocompromised patients. Aerosolized ribavirin (RBV AER) is used for treatment of RSV LRTI; however, adverse events and rising drug costs remain a challenge for patient management. The purpose of this systematic review is to summarize the efficacy and adverse event profile of RBV AER for the treatment of hospitalized RSV LRTI in immunocompromised adult patients. Read More

Ann Hepatol 2020 Sep - Oct;19(5):530-534. Epub 2020 May 26.

Department of General Surgery, Shanghai Children's Medical Center (National Children's Medical Center-Shanghai), Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address:

Introduction And Objectives: Infantile hepatic hemangioendothelioma (IHHE) is a benign liver tumor, associated with hypothyroidism and vascular malformations along the skin, brain, digestive tract and other organs. Here, we determined a single-center patient cohort by evaluating the effectiveness and safety of propranolol and sirolimus for the treatment of IHHE.

Patients And Methods: We performed a monocentric and observational study, based on clinical data obtained from 20 cases of IHHE treated with oral propranolol and sirolimus at the Shanghai Children's Medical Center (SCMC), between December 2017 and April 2019. Read More

Zhongguo Zhong Yao Za Zhi 2020 May;45(10):2316-2321

School of Statistics, Renmin University of China Beijing 100872, China.

From January 1, 2004 to July 21, 2016 a total of 2 796 cases of adverse drug reaction/adverse event(ADR/AE) after the use of Xianling Gubao Capsules/Tablets were reported by National Adverse Drug Reaction Monitoring Center. The following results were obtained by analyzing the reports of 2 796 cases of adverse drug reactions/adverse drug events after the use of Xianling Gubao Capsules/Tablets. A total of 75 patients, accounting for 2. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Feb;45(2):216-220

Department of Periodontics & Oral Mucosal Section, Xiangya Stomatological Hospital & Xiangya School of Stomatology & Hunan Key Laboratory of Oral Health Research, Central South University, Changsha 410008, China

Glucocorticoid is a commonly used anti-inflammatory and anti-allergic drug in clinic. Allergic reactions caused by glucocorticoids are rare in clinic. Glucocorticoid allergy is a type of allergic reaction caused by glucocorticoid as an allergen, and its clinical manifestations of hypersensitivity are not specific. Read More

BMC Pediatr 2020 04 17;20(1):170. Epub 2020 Apr 17.

Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jalan Diponegoro 71, DKI Jakarta, 10430, Indonesia.

Background: Systemic fungal infection (SFI) is one of leading causes of morbidity and mortality in very low birth weight (VLBW) preterm infants. Because early diagnosis of SFI is challenging due to nonspecific manifestations, prophylaxis becomes crucial. This study aimed to assess effectiveness of oral nystatin as an antifungal prophylaxis to prevent SFI in VLBW preterm infants. Read More

Rev Prat 2019 Oct;69(8):861-867

Service de stomatologie et chirurgie maxillofaciale, groupe hospitalier La Pitié-Salpêtrière- Charles-Foix, département hospitalouniversitaire « Fight Ageing and Stress » (DHU FAST) Paris, France. Sorbonne Universités, UPMC Univ Paris 06, UMR 8256 B2A, Paris, France.

Mouth and medication. Medication holds a prominent place for better comfort and increased life expectancy. Adverse effects and drug interactions are frequently observed and reported. Read More

Rev Prat 2019 Sep;69(7):767-773

Centre de référence des syndromes hyperéosinophiliques (CEREO). Service de médecine interne, hôpital Ambroise-Paré, Boulogne-Billancourt ; université Versailles Saint-Quentin-en- Yvelines, France.

Hypereosinophilic syndromes. Hypereosinophilic syndromes (HES) is a protean condition defined by chronic blood eosinophilia ≥ 1.5 G/L (> 1 month) leading to eosinophilic-related organ damage. Read More

Int J Paediatr Dent 2020 Jul 24;30(4):489-496. Epub 2020 Jan 24.

School of Dental Medicine, University of Puerto Rico, San Juan, Puerto Rico.

Stevens-Johnson syndrome (SJS) is a disorder forming one of the several severe cutaneous adverse reactions, a group that includes, as well, erythema multiforme, toxic epidermal necrolysis (TEN), and SJS/TEN overlap. These adverse reactions are characterized by their severe involvement of the skin and the oral, gastrointestinal, genital, and conjunctival mucosa. The purposes of the study described herein were to perform a literature review of studies describing the clinical presentations and management of SJS patients with oral manifestations and to present a case report of a patient treated with dapsone gel. Read More

J Dermatol 2020 Mar 6;47(3):223-235. Epub 2020 Jan 6.

Institute of Dermato-Immunology and Allergy, Southern Tohoku General Hospital, Koriyama, Japan.

In the current study, we present guidelines for the diagnosis and treatment of the mucocutaneous lesions of Behçet's disease, which is a chronic inflammatory disease characterized by the involvement of various organs, including mucocutaneous, ocular, vascular, intestinal and central nervous system lesions. It is often identified in the Middle East Mediterranean to East Asia region. Skin manifestations include erythema nodosum, papulopustular lesions and thrombophlebitis, and mucosal manifestations include oral and genital ulcers. Read More

Pediatr Transplant 2020 02 15;24(1):e13626. Epub 2019 Dec 15.

Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

TBC regimens are considered as "reduced toxicity" and are increasingly employed in pediatric HSCT. In our center, we commonly use the combination of treosulfan-thiotepa-fludarabine and ATG for pediatric non-malignant diseases. As we often observe acute skin toxicities following this conditioning regimen, we conducted a prospective observational study to describe and characterize these toxicities. Read More

Int J Surg Pathol 2020 May 31;28(3):280-283. Epub 2019 Oct 31.

Rashid Hospital, Dubai, United Arab Emirates.

Alvogyl dressing is used to help control hemostasis, foster healing, and prevent complications after certain oral procedures. It is a paste composed of different antiseptic and analgesic substances, and fern-derived Penghawar djambi fibers that have styptic properties. It is claimed to be a resorbable and self-eliminating paste with little complications. Read More

BMJ Case Rep 2019 Oct 25;12(10). Epub 2019 Oct 25.

Internal Medicine, University of South Dakota Sanford, School of Medicine, Sioux Falls, South Dakota, USA

Amiodarone is an antiarrhythmic agent that is used commonly in clinical practice. It is associated with many side effects, the most common being pulmonary manifestations. Interstitial pneumonitis is one of the most common complications, however rarely amiodarone can cause diffuse alveolar haemorrhage (DAH) too. Read More

Indian Dermatol Online J 2019 Sep-Oct;10(5):547-554. Epub 2019 Aug 28.

Department of Pharmacology, Govt. Medical College, Gandhi Nagar, Kottayam, Kerala, India.

Context: Cutaneous adverse drug reactions (CADRs) are the most frequent of all manifestations of drug sensitivity that present with varied and diverse morphology and therefore, awareness about them is essential for diagnosis and prevention. Aims: To evaluate the clinical spectrum, morphology, causality, severity and preventability of cutaneous adverse drug reactions in a tertiary care hospital.

Setting And Design: Descriptive study for six months in the Dermatology Department of a tertiary care hospital in Kerala. Read More

Acta Dermatovenerol Croat 2019 Sep;27(3):200-201

Richard Akintayo, MD, Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria;

Dear Editor, Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by diverse patterns of auto-antibody production with multi-organ affectation. Cutaneous involvement, either alone or in association with other systemic illnesses, is one of its most common manifestations (1). Dermatologic disorders like malar and discoid rashes are quite suggestive of SLE. Read More