427 results match your criteria Oral Manifestations of Drug Reactions


Propranolol for infantile hepatic hemangioendothelioma: Clinical evaluation of drug efficacy and safety using a single-center patient cohort.

Ann Hepatol 2020 May 26. Epub 2020 May 26.

Department of General Surgery, Shanghai Children's Medical Center (National Children's Medical Center-Shanghai), Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address:

Introduction And Objectives: Infantile hepatic hemangioendothelioma (IHHE) is a benign liver tumor, associated with hypothyroidism and vascular malformations along the skin, brain, digestive tract and other organs. Here, we determined a single-center patient cohort by evaluating the effectiveness and safety of propranolol and sirolimus for the treatment of IHHE.

Patients And Methods: We performed a monocentric and observational study, based on clinical data obtained from 20 cases of IHHE treated with oral propranolol and sirolimus at the Shanghai Children's Medical Center (SCMC), between December 2017 and April 2019. Read More

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http://dx.doi.org/10.1016/j.aohep.2020.04.008DOI Listing
May 2020
2.193 Impact Factor

[Analysis of adverse reactions of Xianling Gubao preparation based on real world SRS data].

Zhongguo Zhong Yao Za Zhi 2020 May;45(10):2316-2321

School of Statistics, Renmin University of China Beijing 100872, China.

From January 1, 2004 to July 21, 2016 a total of 2 796 cases of adverse drug reaction/adverse event(ADR/AE) after the use of Xianling Gubao Capsules/Tablets were reported by National Adverse Drug Reaction Monitoring Center. The following results were obtained by analyzing the reports of 2 796 cases of adverse drug reactions/adverse drug events after the use of Xianling Gubao Capsules/Tablets. A total of 75 patients, accounting for 2. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200211.505DOI Listing

A case of delayed allergic reaction caused by local injection of triamcinolone acetonide.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Feb;45(2):216-220

Department of Periodontics & Oral Mucosal Section, Xiangya Stomatological Hospital & Xiangya School of Stomatology & Hunan Key Laboratory of Oral Health Research, Central South University, Changsha 410008, China

Glucocorticoid is a commonly used anti-inflammatory and anti-allergic drug in clinic. Allergic reactions caused by glucocorticoids are rare in clinic. Glucocorticoid allergy is a type of allergic reaction caused by glucocorticoid as an allergen, and its clinical manifestations of hypersensitivity are not specific. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2020.180584DOI Listing
February 2020

Oral nystatin prophylaxis to prevent systemic fungal infection in very low birth weight preterm infants: a randomized controlled trial.

BMC Pediatr 2020 Apr 17;20(1):170. Epub 2020 Apr 17.

Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jalan Diponegoro 71, DKI Jakarta, 10430, Indonesia.

Background: Systemic fungal infection (SFI) is one of leading causes of morbidity and mortality in very low birth weight (VLBW) preterm infants. Because early diagnosis of SFI is challenging due to nonspecific manifestations, prophylaxis becomes crucial. This study aimed to assess effectiveness of oral nystatin as an antifungal prophylaxis to prevent SFI in VLBW preterm infants. Read More

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http://dx.doi.org/10.1186/s12887-020-02074-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164192PMC
April 2020
1.918 Impact Factor

[Mouth and medication].

Authors:
Lotfi Ben Slama

Rev Prat 2019 Oct;69(8):861-867

Service de stomatologie et chirurgie maxillofaciale, groupe hospitalier La Pitié-Salpêtrière- Charles-Foix, département hospitalouniversitaire « Fight Ageing and Stress » (DHU FAST) Paris, France. Sorbonne Universités, UPMC Univ Paris 06, UMR 8256 B2A, Paris, France.

Mouth and medication. Medication holds a prominent place for better comfort and increased life expectancy. Adverse effects and drug interactions are frequently observed and reported. Read More

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October 2019

[Hypereosinophilic syndromes].

Rev Prat 2019 Sep;69(7):767-773

Centre de référence des syndromes hyperéosinophiliques (CEREO). Service de médecine interne, hôpital Ambroise-Paré, Boulogne-Billancourt ; université Versailles Saint-Quentin-en- Yvelines, France.

Hypereosinophilic syndromes. Hypereosinophilic syndromes (HES) is a protean condition defined by chronic blood eosinophilia ≥ 1.5 G/L (> 1 month) leading to eosinophilic-related organ damage. Read More

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September 2019

Treatment for oral lesions in pediatric patients with Stevens-Johnson's syndrome: A case report and literature review.

Int J Paediatr Dent 2020 Jul 24;30(4):489-496. Epub 2020 Jan 24.

School of Dental Medicine, University of Puerto Rico, San Juan, Puerto Rico.

Stevens-Johnson syndrome (SJS) is a disorder forming one of the several severe cutaneous adverse reactions, a group that includes, as well, erythema multiforme, toxic epidermal necrolysis (TEN), and SJS/TEN overlap. These adverse reactions are characterized by their severe involvement of the skin and the oral, gastrointestinal, genital, and conjunctival mucosa. The purposes of the study described herein were to perform a literature review of studies describing the clinical presentations and management of SJS patients with oral manifestations and to present a case report of a patient treated with dapsone gel. Read More

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http://dx.doi.org/10.1111/ipd.12615DOI Listing

Amiodarone-induced diffuse alveolar haemorrhage: a rare but potentially life-threatening complication of a commonly prescribed medication.

BMJ Case Rep 2019 Oct 25;12(10). Epub 2019 Oct 25.

Internal Medicine, University of South Dakota Sanford, School of Medicine, Sioux Falls, South Dakota, USA

Amiodarone is an antiarrhythmic agent that is used commonly in clinical practice. It is associated with many side effects, the most common being pulmonary manifestations. Interstitial pneumonitis is one of the most common complications, however rarely amiodarone can cause diffuse alveolar haemorrhage (DAH) too. Read More

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http://dx.doi.org/10.1136/bcr-2019-232149DOI Listing
October 2019

Pharmacovigilance of Cutaneous Adverse Drug Reactions among Patients Attending Dermatology Department at a Tertiary Care Hospital.

Indian Dermatol Online J 2019 Sep-Oct;10(5):547-554. Epub 2019 Aug 28.

Department of Pharmacology, Govt. Medical College, Gandhi Nagar, Kottayam, Kerala, India.

Context: Cutaneous adverse drug reactions (CADRs) are the most frequent of all manifestations of drug sensitivity that present with varied and diverse morphology and therefore, awareness about them is essential for diagnosis and prevention. Aims: To evaluate the clinical spectrum, morphology, causality, severity and preventability of cutaneous adverse drug reactions in a tertiary care hospital.

Setting And Design: Descriptive study for six months in the Dermatology Department of a tertiary care hospital in Kerala. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_419_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743381PMC
August 2019
1 Read

Rowell Syndrome in Nigeria: Systemic Lupus Erythematosus Presenting as Recurrent Erythema Multiforme in a Young Woman.

Acta Dermatovenerol Croat 2019 Sep;27(3):200-201

Richard Akintayo, MD, Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria;

Dear Editor, Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by diverse patterns of auto-antibody production with multi-organ affectation. Cutaneous involvement, either alone or in association with other systemic illnesses, is one of its most common manifestations (1). Dermatologic disorders like malar and discoid rashes are quite suggestive of SLE. Read More

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September 2019
2 Reads

Triggers, clinical manifestations, and management of pediatric erythema multiforme: A systematic review.

J Am Acad Dermatol 2019 Sep 19;81(3):813-822. Epub 2019 Jul 19.

Department of Dermatology, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.

Background: Erythema multiforme (EM) is an acute inflammatory mucocutaneous condition. EM is rarely described in children and infants.

Objective: To investigate the triggers, clinical manifestations, and treatment of pediatric EM. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.02.057DOI Listing
September 2019
5 Reads

[A case of telbivudine-related fatal lactic acidosis and multiple organ dysfunction syndrome].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Jun;44(6):714-719

Department of Emergency, Xiangya Hospital, Central South University, Changsha 410008, China.

The incidence of telbivudine-related adverse reactions has been gradually increased. The increased levels of muscle enzymes and blood lactate are common. In this case, a 23-year-old male patient with long-term oral telbivudine had a rare serious adverse reaction. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2019.06.016DOI Listing
June 2019
5 Reads

[Idiopathic granulomatous mastitis associated with erythema nodosum].

Ann Dermatol Venereol 2019 Sep;146(8-9):571-576

Service de dermatologie, hôpital Nord Franche-Comté, 100, route de Moval 90400 Trévenans, France.

Background: Idiopathic granulomatous mastitis (IGM) is a rare, chronic, granulomatous, inflammatory disorder with potentially misleading clinical and radiological features. IGM is diagnosed after exclusion of infectious or tumoral diseases. Herein we report a case of erythema nodosum associated with IGM, which serves as a reminder that erythema nodosum may constitute an extra-mammary sign of IGM. Read More

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http://dx.doi.org/10.1016/j.annder.2019.04.023DOI Listing
September 2019
8 Reads

Drug reaction with eosinophilia and systemic symptoms in a cohort of Asian children.

Pediatr Dermatol 2019 May 28;36(3):324-329. Epub 2019 Mar 28.

Dermatology Service, KK Women's and Children's Hospital, Singapore, Singapore.

Background/objectives: Drug reaction with eosinophilia and systemic symptoms (DRESS) is rare but potentially fatal in children. Fever and rash, which are salient features of DRESS, may mimic other commonly encountered pediatric conditions. We profiled the DRESS cases in a tertiary children's hospital in Singapore. Read More

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http://dx.doi.org/10.1111/pde.13812DOI Listing
May 2019
22 Reads

Hypersensitivity reactions to food and drug additives: problem or myth?

Acta Biomed 2019 01 29;90(3-S):80-90. Epub 2019 Jan 29.

Pediatric Unit, Department of Medical and Surgical Sciences, University of Bologna, S. Orsola-Malpighi Hospital.

Background And Aim Of The Work: The possibility of an allergic reaction or an intolerance to additives is frequently suspected by parents, especially for chronic illness with frequent exacerbations such as atopic dermatitis or chronic urticaria. For more than 50 years, potential adverse reactions to additives have been suggested, but to date data are conflicting. The purpose of this article is to provide the clinicians with general information about additives and adverse reactions to them and to suggest a practical approach to children suspected to have reactions to food additives. Read More

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http://dx.doi.org/10.23750/abm.v90i3-S.8168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502174PMC
January 2019
29 Reads

Platelet-rich plasma, a powerful tool in dermatology.

J Tissue Eng Regen Med 2019 05 9;13(5):892-901. Epub 2019 Apr 9.

Cellular and Functional Biology and Biomolecules Engineering Group, School of Science, Universidad Antonio Nariño, Bogotá, Colombia.

Platelet-rich plasma (PRP), a platelet concentrate contained in a small volume of plasma, has become a promising option in the last decade to treat different diseases related to the skin due to its high concentration of growth factors. When it is of autologous origin, it decreases the probability of suffering adverse reactions and transfusion-transmitted infections, thus it is an optimal and safe therapy for the patient. PRP has been used in the treatment of several dermatological conditions such as acne, alopecia, and skin ulcers. Read More

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http://dx.doi.org/10.1002/term.2832DOI Listing
May 2019
14 Reads

Clinical Profile and Comparison of Causality Assessment Tools in Cutaneous Adverse Drug Reactions.

Indian Dermatol Online J 2019 Jan-Feb;10(1):27-33

Department of Dermatology, Venereology and Leprology, R.N.T Medical College, Udaipur, Rajasthan, India.

Background: Cutaneous adverse drug reactions (CADRs) are probably the most frequent of all manifestations of drug sensitivity. As a considerable number of new drugs are periodically introduced into the market, the incidence of CADR is likely to increase. The pattern of CADR and the causative drugs is likely to change accordingly. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_207_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362752PMC
February 2019
7 Reads

Eperisone-Induced Anaphylaxis: Pharmacovigilance Data and Results of Allergy Testing.

Allergy Asthma Immunol Res 2019 Mar;11(2):231-240

Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Eperisone is an oral muscle relaxant used in musculoskeletal disorders causing muscle spasm and pain. For more effective pain control, eperisone is usually prescribed together with nonsteroidal anti-inflammatory drugs (NSAIDs). As such, eperisone may have been overlooked as the cause of anaphylaxis compared with NSAIDs. Read More

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http://dx.doi.org/10.4168/aair.2019.11.2.231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340802PMC
March 2019
9 Reads

[Mycoplasma pneumoniae-induced atypical Steven-Johnson syndrome: a diagnostic challenge].

Rev Alerg Mex 2018 Oct-Dec;65(4):437-441

Universidad de Costa Rica, San José, Costa Rica.

Background: Atypical Steven-Johnson syndrome is a rare disease that can be caused by Mycoplasma pneumoniae; it is characterized by respiratory symptoms, mucosal lesions of variable severity and constitutional symptoms, in the absence of cutaneous involvement.

Case Report: We present the case of a 35-old-man who developed mucositis in the conjunctiva, oral cavity and genitalia after the onset of respiratory symptoms. Mycoplasma pneumoniae infection was confirmed, and treatment with antibiotic and steroids was therefore started, whereby clinical manifestations subsided. Read More

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http://dx.doi.org/10.29262/ram.v65i4.357DOI Listing
October 2019

Cefuroxime-induced anaphylaxis with prominent central nervous system manifestations: A case report.

J Int Med Res 2019 Feb 7;47(2):1010-1014. Epub 2018 Dec 7.

1 Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Wangfujing, Beijing, China.

Cefuroxime is a second-generation cephalosporin antibiotic that causes immediate hypersensitivity reactions, ranging from mild urticaria to severe anaphylactic shock. Anaphylactic reactions typically involve multiple systems, most notably, the skin and the respiratory and cardiovascular systems. Here, we report the unusual case of a patient who presented with oral cefuroxime-induced anaphylaxis with prominent neurologic manifestations. Read More

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http://dx.doi.org/10.1177/0300060518814118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381482PMC
February 2019
21 Reads

Treatment of oral manifestations of toxic epidermal necrolysis with low-level laser therapy in a pediatric patient.

Pediatr Dermatol 2019 Jan 26;36(1):e27-e30. Epub 2018 Nov 26.

Department of Oral Surgery and Pathology, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Drug-induced reactions are complications associated with high mortality and significant morbidity. Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are examples of these conditions, which are characterized by skin and mucous lesions. Here, we report a case of a 9-year-old girl who presented with blisters associated with an extensive vesicular rash and multiple ulcerations on the lips and oral cavity. Read More

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http://doi.wiley.com/10.1111/pde.13719
Publisher Site
http://dx.doi.org/10.1111/pde.13719DOI Listing
January 2019
59 Reads

The impact of tacrolimus exposure on extrarenal adverse effects in adult renal transplant recipients.

Br J Clin Pharmacol 2019 03 4;85(3):516-529. Epub 2019 Jan 4.

Erie County Medical Center, Division of Nephrology; Department of Medicine: Nephrology Division; School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.

Aims: Tacrolimus has been associated with notable extrarenal adverse effects (AEs), which are unpredictable and impact patient morbidity. The association between model-predicted tacrolimus exposure metrics and standardized extrarenal AEs in stable renal transplant recipients was investigated and a limited sampling strategy (LSS) was developed to predict steady-state tacrolimus area under the curve over a 12-h dosing period (AUC ).

Methods: All recipients receiving tacrolimus and mycophenolic acid ≥6 months completed a 12-h cross-sectional observational pharmacokinetic-pharmacodynamic study. Read More

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http://doi.wiley.com/10.1111/bcp.13811
Publisher Site
http://dx.doi.org/10.1111/bcp.13811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379234PMC
March 2019
38 Reads

Correlating CD4 count with mucocutaneous manifestations in HIV-positive patients: A prospective study.

Indian J Sex Transm Dis AIDS 2017 Jul-Dec;38(2):128-135

Department of Community Medicine, Government Villupuram Medical College and Hospital, Villupuram, Tamil Nadu, India.

Background: Mucocutaneous findings may be the presenting symptoms in HIV-afflicted individuals. A multitude of mucocutaneous diseases also occurs during the course of the ailment, with some conditions being classed as disease defining. They include infectious diseases and noninfective inflammatory and neoplastic dermatoses. Read More

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http://dx.doi.org/10.4103/ijstd.IJSTD_130_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085934PMC
August 2018
13 Reads

Managing Clopidogrel Hypersensitivity without Interrupting Therapy: The Toronto Approach.

Authors:
Asim N Cheema

Curr Vasc Pharmacol 2019 ;17(2):119-122

Division of Cardiology, Terrence Donnelly Heart Center, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada.

Clopidogrel remains a widely used antiplatelet agent for patients with established or high risk of atherothrombotic disease, particularly those treated with coronary, carotid or peripheral endovascular stenting. Clopidogrel hypersensitivity is an uncommon but well established adverse drug reaction presenting a challenge for patient management. The clinical presentation ranges from focal or diffuse cutaneous manifestations in most patients to angioedema in some and a systemic immune response in rare cases. Read More

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http://dx.doi.org/10.2174/1389200219666180820114435DOI Listing
May 2020
2 Reads

[The state-of-the-art development in research on oral mucositis induced by chemotherapy].

Zhonghua Kou Qiang Yi Xue Za Zhi 2018 Aug;53(8):566-571

Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Chengdu 610041, China.

Chemotherapy is one of the effective methods to treat cancer. However, the chemotherapy agents may cause a series of adverse reactions due to the nonselective characteristics that affect not only tumor cells, but also normal cells. Oral mucositis induced by chemotherapy is a common oral complication caused by chemotherapy in clinic. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2018.08.015DOI Listing
August 2018
5 Reads

Extravascular manifestations of Takayasu arteritis: focusing on the features shared with spondyloarthritis.

Arthritis Res Ther 2018 07 11;20(1):142. Epub 2018 Jul 11.

Division of Rheumatology, Department of Internal Medicine, University of Ulsan, College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Background: Takayasu arteritis (TAK) is a systemic disease characterized by large vessel involvement. Although the vascular characteristics of TAK are well characterized, there is no well-organized study demonstrating the extravascular manifestations of TAK. We aimed to evaluate the characteristics of extravascular manifestations of TAK, and to identify the association between vascular and extravascular manifestations of TAK. Read More

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http://dx.doi.org/10.1186/s13075-018-1643-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042334PMC
July 2018
25 Reads

Exogenous recombinant human thioredoxin-1 prevents acetaminophen-induced liver injury by scavenging oxidative stressors, restoring the thioredoxin-1 system and inhibiting receptor interacting protein-3 overexpression.

J Appl Toxicol 2018 07 7;38(7):1008-1017. Epub 2018 Mar 7.

College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, 1 Kangwondaehak-gil, Chuncheon, Gangwon, 24341, Republic of Korea.

Thioredoxin-1 (Trx-1) is a potent therapeutic agent against a variety of diseases because of its actions as an antioxidant and regulator of apoptosis. N-acetyl-p-aminophenol (APAP), commonly known as acetaminophen, generates excessive oxidative stress and triggers hepatocyte cell death, exemplified by regulated necrosis. In the present study, we investigated whether APAP-induced liver injury in a mouse model is associated with "necroptosis," and if pretreatment with recombinant Trx-1 prevents the hepatic injury caused by APAP overdose. Read More

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http://dx.doi.org/10.1002/jat.3609DOI Listing
July 2018
2 Reads

Orofacial manifestations of adverse drug reactions: a review study.

Clujul Med 2018 15;91(1):27-36. Epub 2018 Jan 15.

Oral Medicine Department, Dental Faculty, Shahid Beheshti University of Medical Sciences, Islamic Republic of Iran.

Background: Adverse reaction to medication is common and may have a variety of clinical manifestations in the oral cavity. The present review paper aimed to describe adverse drug reactions (ADRs) which might be encountered by dental practitioners in every discipline.

Methods: In this narrative review article, the specialized databases such as PubMed, PubMed Central, MEDLINE, EBSCO, Science Direct, Scopus, and reference books from the years 2000-2016 were used to find relevant documents by using MeSH terms: Adverse Drug Reaction, Drug induced, Medication Related, Mouth, Oral Manifestation, Tooth, Hard Tissue, Soft Tissue. Read More

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http://dx.doi.org/10.15386/cjmed-748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808263PMC
January 2018
14 Reads

Establishing a Safe Administration of ASA in Cardiovascular Patients with Nonsteroidal Anti-Inflammatory Drug Hypersensitivity with Skin and/or Respiratory Involvement.

Int Arch Allergy Immunol 2018;175(4):237-245. Epub 2018 Jan 26.

Sabah Al Ahmed Cardiac Center, Ministry of Health, Kuwait City, Kuwait.

Background: A history of nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity with cross-intolerance to several drugs is common in some patients with coronary artery disease. We present a series of patients with acute coronary syndrome undergoing ASA desensitization prior to a possible stent to evaluate the short- and long-term efficacy and safety. The aim was to evaluate the outcomes of an ASA desensitization protocol developed by our center based on the guidelines proposed by the EAACI drug allergy expert recommendations. Read More

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http://dx.doi.org/10.1159/000486415DOI Listing
May 2018
20 Reads

[Retrospective analysis of adverse drug reactions in stomatology hospital from 2014 to 2016].

Hua Xi Kou Qiang Yi Xue Za Zhi 2017 Dec;35(6):625-628

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Medical Affairs, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Objective: This study aims to investigate the characteristics and general rules of adverse drug reactions (ADR) in a 3A-grade stomatology hospital for safe and rational drug use in clinical stomatology.

Methods: We retrospectively analyzed 52 ADR cases (1∶1.36, males∶females) reported in the West China Hospital of Stomatology of Sichuan University from 2014 to 2016 in terms of gender and age distributions, drug categories, and clinical manifestations. Read More

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http://dx.doi.org/10.7518/hxkq.2017.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041168PMC
December 2017
12 Reads

Dermatologic Reactions to Immune Checkpoint Inhibitors : Skin Toxicities and Immunotherapy.

Authors:
Vincent Sibaud

Am J Clin Dermatol 2018 Jun;19(3):345-361

Oncodermatology, Institut Claudius REGAUD and Institut Universitaire du Cancer Toulouse Oncopole, 1 avenue Irène Joliot-Curie, 31059, Toulouse Cedex 9, France.

The development of immune checkpoint inhibitors [monoclonal antibodies targeting cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), programmed cell death protein 1 (PD-1) or programmed death ligand 1 (PD-L1)] represents a major breakthrough in cancer therapy. Although they present a favorable risk/benefit ratio, immune checkpoint blockade therapies have a very specific safety profile. Due to their unique mechanism of action, they entail a new spectrum of adverse events that are mostly immune related [immune-related adverse events (irAEs)], notably mediated by the triggering of cytotoxic CD4+/CD8+ T cell activation. Read More

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http://dx.doi.org/10.1007/s40257-017-0336-3DOI Listing
June 2018
21 Reads

Early cutaneous eruptions after oral hydroxychloroquine in a lupus erythematosus patient: A case report and review of the published work.

J Dermatol 2018 Mar 14;45(3):344-348. Epub 2017 Dec 14.

Department ofDermatology, Kansai Medical University, Hirakata, Japan.

Hydroxychloroquine (HCQ) is an effective treatment of lupus erythematosus. Although adverse effects, mainly gastrointestinal and cutaneous manifestations, are rare, they may result in the cessation of medication in some patients with severe reactions. Therefore, the evaluation of a patient's condition is important for a dermatologist to decide whether to cease or continue HCQ. Read More

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http://dx.doi.org/10.1111/1346-8138.14156DOI Listing
March 2018
23 Reads

[Clinical problems in medical mycology: Problem number 52].

Rev Iberoam Micol 2018 Jan - Mar;35(1):59-61. Epub 2017 Nov 27.

Unidad Micología, Hospital de Infecciosas F. J. Muñiz, Ciudad Autónoma de Buenos Aires, Argentina.

The case of a 60 year old woman with hemoptysis and a thin-walled cavitary lesion at the upper lobe of the right lung is presented. The woman presented at the Mycology Unit of the Muñiz Hospital in Buenos Aires City 3 months after the beginning of her clinical manifestations. A hyaline micelial fungus with chlamido-arthroconidias was isolated from the bronchoalveolar lavage. Read More

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http://dx.doi.org/10.1016/j.riam.2017.09.002DOI Listing
September 2018
14 Reads

Anesthesia in a child with suspected peroxisomal disorder.

Anaesthesist 2017 Dec 8;66(12):944-947. Epub 2017 Nov 8.

Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Muenster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Münster, Germany.

We present the case of an 8‑year-old female child with suspected peroxisomal disorder requiring general anesthesia for adenotomy, paracentesis and brainstem-evoked response audiometry. Peroxisomes are small intracellular organelles that catalyse key metabolic reactions. Peroxisomal disorders are a heterogeneous group of rare genetic diseases. Read More

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http://dx.doi.org/10.1007/s00101-017-0379-0DOI Listing
December 2017
14 Reads

Animal models of chemotherapy-induced mucositis: translational relevance and challenges.

Am J Physiol Gastrointest Liver Physiol 2018 02 26;314(2):G231-G246. Epub 2017 Oct 26.

Hans Christian Andersen Children's Hospital, Odense University Hospital , Odense , Denmark.

Chemotherapy for cancer patients induces damaging tissue reactions along the epithelium of the gastrointestinal tract (GIT). This chemotherapy-induced mucositis (CIM) is a serious side effect of cytotoxic drugs, and several animal models of CIM have been developed, mainly in rodents and piglets, to help understand the progression of CIM and how to prevent it. Animal models allow highly controlled experimental conditions, detailed organ (e. Read More

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http://dx.doi.org/10.1152/ajpgi.00204.2017DOI Listing
February 2018
12 Reads

Hydroxychloroquine desensitization, an effective method to overcome hypersensitivity-a multicenter experience.

Lupus 2018 Apr 9;27(5):703-707. Epub 2017 Oct 9.

2 Clinical Immunology, Angioedema and Allergy Unit, The Zabludowicz Center for Autoimmune Diseases, 26744 Sheba Medical Center, Tel Hashomer , Israel.

Hydroxychloroquine (HCQ) is widely used to treat autoimmune/rheumatic diseases such as systemic lupus erythematosus (SLE). The immune modulation effects of HCQ have been highlighted as beneficial for maintaining remission of SLE as well as ameliorating skin, joint and other manifestations. Moreover, HCQ exposure for prolonged periods as well as during pregnancy is considered safe, therefore it is recommended for the vast majority of SLE patients. Read More

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http://dx.doi.org/10.1177/0961203317735185DOI Listing
April 2018
60 Reads

Acetyl Salicylic Acid Challenge in Children with Hypersensitivity Reactions to Nonsteroidal Anti-Inflammatory Drugs Differentiates Between Cross-Intolerant and Selective Responders.

J Allergy Clin Immunol Pract 2018 Jul - Aug;6(4):1226-1235. Epub 2017 Oct 3.

Allergy Service, Infanta Leonor University Hospital, Madrid, Spain.

Background: Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) in children are becoming a great concern. Most studies have focused on adults, with noted discrepancies observed in the classification of hypersensitivity reactions to NSAIDs in children when compared with adults.

Objective: To phenotype a group of children with hypersensitivity reactions to NSAIDs, including paracetamol, and analyze the degree of agreement with the entities reported in adults and how they fit the proposed classifications. Read More

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http://dx.doi.org/10.1016/j.jaip.2017.08.029DOI Listing
October 2019
64 Reads

Mucocutaneous manifestations in human immunodeficiency virus (HIV)-infected patients in Nouakchott, Mauritania.

Int J Dermatol 2017 Dec 27;56(12):1421-1424. Epub 2017 Sep 27.

Research Unit of Emerging Infectious and Tropical Diseases (URMITE), Institut de Recherche pour le Développement 198, Institut Hospitalo-Universitaire - Méditerranée Infection, Aix-Marseille University, Marseille, France.

Background: Mucocutaneous manifestations are one of the first clinical signs in patients infected with human immunodeficiency virus (HIV). To the best of our knowledge, there has been no previous study describing dermatologic manifestations in Mauritanians infected with HIV. The aim of the present study was to determine the profiles of mucocutaneous manifestations in relation to CD T cell count in HIV-positive Mauritanian patients. Read More

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http://dx.doi.org/10.1111/ijd.13737DOI Listing
December 2017
38 Reads

Skin Manifestations of Inflammatory Bowel Disease.

Clin Rev Allergy Immunol 2017 Dec;53(3):413-427

Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.

Inflammatory bowel disease (IBD) with its two main subtypes Crohn's disease and ulcerative colitis is not restricted to the gastrointestinal tract. Indeed, so-called extraintestinal manifestations (EIMs) are frequent and considerably affect morbidity and mortality. The prevalence of EIMs ranges from 6 to 47%. Read More

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http://dx.doi.org/10.1007/s12016-017-8617-4DOI Listing
December 2017
13 Reads

Adverse Drug Reactions and Cutaneous Manifestations Associated With Anticoagulation.

J Cutan Med Surg 2017 Nov/Dec;21(6):540-550. Epub 2017 Jun 22.

2 Skin Centre for Dermatology, Peterborough, ON, Canada.

Anticoagulants are amongst the most commonly prescribed medications worldwide. Although rare, localised and systemic drug reactions have been reported with anticoagulants that can lead to significant morbidity and mortality. Some of the first signs of drug reactions to anticoagulants are cutaneous changes that, when recognised early, can prevent significant complications. Read More

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http://dx.doi.org/10.1177/1203475417716364DOI Listing
July 2018
59 Reads

Autoimmune progesterone dermatitis presenting as fixed drug eruption: a case report.

Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.

Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Autoimmune progesterone dermatitis (APD) is a rare disorder characterized by periodic skin lesions that erupt during the luteal phase of the menstrual cycle. Clinical manifestations of APD is caused by an unusual allergy to progesterone and has a wide range of clinical manifestations from eczema and urticaria to angioedema and erythema multiforme. A 46-year-old woman described recurrent, round erythematous plaques on the lower lip, both forearms and buttocks. Read More

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June 2017
36 Reads

Immediate hypersensitivity reaction to pegylated liposomal doxorubicin: management and outcome in four patients.

Eur J Dermatol 2017 Jun;27(3):271-274

Department of Dermatology, Saint-André Hospital CHU Bordeaux, Bordeaux, France, INSERM U1053, Bordeaux Research in Translational Oncology University Bordeaux, Bordeaux, France, French Study Group of Cutaneous Lymphoma (GFELC).

Hypersensitivity reactions (HSR) to pegylated liposomal doxorubicin (PLD; Caelyx) have been reported, and symptoms usually resolve with drug withdrawal. However, the risk of relapse of severe HSR and prevention remain poorly described. To report the management and outcome in four patients with HSR due to PLD. Read More

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http://dx.doi.org/10.1684/ejd.2017.2986DOI Listing
June 2017
86 Reads

Ivermectin induced Steven-Johnsons syndrome: case report.

BMC Res Notes 2017 May 8;10(1):179. Epub 2017 May 8.

Presbyterian General Hospital Acha-Tugi, Acha, Cameroon.

Background: Stevens-Johnson syndrome is one of the manifestations of mucocutaneous adverse drug reactions. Although antimicrobials are responsible for greater than 50% of these adverse drug reactions, there is no documented case implicating ivermectin as the culprit. A 38 year old adult Cameroonian male presented to our health facility with facial rash, painful oral sores, black eschars on lips and red tearing eyes 3 days following ingestion of ivermectin received during a nationwide anti-filarial campaign. Read More

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http://dx.doi.org/10.1186/s13104-017-2500-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422988PMC
May 2017
15 Reads

Cutaneous Manifestations of Diabetes Mellitus: A Review.

Am J Clin Dermatol 2017 Aug;18(4):541-553

Department of Dermatology, University Hospital Jena, Erfurter Straße 35, 07740, Jena, Germany.

Diabetes mellitus is a widespread endocrine disease with severe impact on health systems worldwide. Increased serum glucose causes damage to a wide range of cell types, including endothelial cells, neurons, and renal cells, but also keratinocytes and fibroblasts. Skin disorders can be found in about one third of all people with diabetes and frequently occur before the diagnosis, thus playing an important role in the initial recognition of underlying disease. Read More

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http://dx.doi.org/10.1007/s40257-017-0275-zDOI Listing
August 2017
25 Reads

Role of bromocriptine in multi-spectral manifestations of traumatic brain injury.

Chin J Traumatol 2017 Apr 21;20(2):84-86. Epub 2017 Feb 21.

Department of Neurosurgery, College of Medical Sciences, Bharatpur, Nepal.

Purpose: Despite the prevalence and cost of traumatic brain injury related disabilities, there is paucity in the literature on modern approaches to pharmacotherapy. Medications may promote recovery by enhancing some neurological functions without impacting others. Herein we discussed the role of bromocriptine in neurorehabilitation for patients with traumatic brain injury. Read More

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http://dx.doi.org/10.1016/j.cjtee.2016.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392713PMC
April 2017
43 Reads

Stevens-Johnson Syndrome: A Review and Report of Two Cases.

Pediatr Dent 2017 Jan;39(1):9-14

Professor and chairperson, Departments of Pediatric Dentistry, Children's Hospital Colorado and School of Dental Medicine Delta Dental of Colorado Endowed Chair in Pediatric Dentistry, in Aurora, Colo., USA.

Stevens-Johnson syndrome (SJS) is a rare condition, characterized by its dramatic involvement of the skin and various mucosal surfaces including the oral mucosae, that severely impairs the affected patient's ability to speak, chew, or swallow. The purpose of this report was to present two cases with significant variations in the clinical presentation of Stevens-Johnson syndrome. In both situations, the patients' conditions were not immediately recognized. Read More

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January 2017
8 Reads

Orofacial manifestations in patients with inflammatory rheumatic diseases.

Authors:
John Hamburger

Best Pract Res Clin Rheumatol 2016 10 18;30(5):826-850. Epub 2016 Nov 18.

Birmingham Behçet's Syndrome Centre of Excellence, Sheldon Block, Birmingham and Midland Eye Centre, City Hospital, Dudley Road, Birmingham, B18 7QH, UK. Electronic address:

The main orofacial manifestation of the inflammatory rheumatic diseases is that of Sjögren's syndrome. In addition, there is a constellation of orofacial manifestations of the inflammatory rheumatic diseases, many of which are extra-articular with some constituting presenting signs of the underlying rheumatic disease. This review will discuss the orofacial manifestations in a variety of connective tissue diseases and will also allude to the oral adverse drug reactions that may occur as a consequence of therapy. Read More

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http://dx.doi.org/10.1016/j.berh.2016.09.013DOI Listing
October 2016
19 Reads

Cofactors and comorbidities in patients with aspirin/NSAID hypersensitivity.

Allergol Immunopathol (Madr) 2017 Nov - Dec;45(6):573-578. Epub 2016 Nov 17.

Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad, Caracas, Venezuela; Allergy Service, Centro Médico de Caracas, Caracas, Venezuela.

Hypersensitivity reactions to aspirin and other NSAIDs occur in individuals genetically predisposed and exhibit different clinical manifestations, especially respiratory, cutaneous, and generalised. Five different phenotypes define distinct clinical pictures: aspirin-exacerbated respiratory disease, aspirin/NSAID cutaneous disease, NSAID-induced urticaria, angio-oedema and anaphylaxis, single NSAID reactions, and delayed reactions. They are observed more frequently in middle-aged women, and in atopic individuals. Read More

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http://dx.doi.org/10.1016/j.aller.2016.08.010DOI Listing
June 2018
29 Reads

Case of Steven-Johnson Syndrome in a male with breast cancer secondary to docetaxel/cyclophosphamide therapy.

BMJ Case Rep 2016 Nov 15;2016. Epub 2016 Nov 15.

Department of Pulmonary and Critical Care, University of Arizona, Tucson, Arizona, USA.

The mortality rate for Stevens-Johnson syndrome (SJS) is estimated to be ∼12% and for toxic epidermal necrolysis (TEN) it is around 30%. It continues to be a severe life-threatening drug reaction. We present a 60-year-old Caucasian man with a medical history significant for breast cancer status post mastectomy and chemotherapy with docetaxel and cyclophosphamide who presented with severe mucositis and a progressing skin rash consistent with SJS. Read More

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http://dx.doi.org/10.1136/bcr-2016-217255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129142PMC
November 2016
19 Reads

Therapeutic Hotline. Oral allicin in the treatment of Behcet's disease through attenuating oxidative stress: A pilot study in 20 patients with mucocutaneous lesions.

Dermatol Ther 2017 Jan 9;30(1). Epub 2016 Oct 9.

Department of Epidemiology and Statistics, Luzhou Medical College, Luzhou, 646000, China.

Behçet's disease (BD) involves oxidative stress (OS) aggression and imbalanced oxidant/antioxidant status. Owing to its antioxidant property, allicin is proposed for treating BD. In this study, we aimed to investigate the efficacy and safety of allicin on patients with BD with mucocutaneous involvement. Read More

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http://dx.doi.org/10.1111/dth.12429DOI Listing
January 2017
31 Reads