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Acta Biomed 2019 Jan 29;90(3-S):80-90. Epub 2019 Jan 29.

Pediatric Unit, Department of Medical and Surgical Sciences, University of Bologna, S. Orsola-Malpighi Hospital.

Background And Aim Of The Work: The possibility of an allergic reaction or an intolerance to additives is frequently suspected by parents, especially for chronic illness with frequent exacerbations such as atopic dermatitis or chronic urticaria. For more than 50 years, potential adverse reactions to additives have been suggested, but to date data are conflicting. The purpose of this article is to provide the clinicians with general information about additives and adverse reactions to them and to suggest a practical approach to children suspected to have reactions to food additives. Read More

Indian Dermatol Online J 2019 Jan-Feb;10(1):27-33

Department of Dermatology, Venereology and Leprology, R.N.T Medical College, Udaipur, Rajasthan, India.

Background: Cutaneous adverse drug reactions (CADRs) are probably the most frequent of all manifestations of drug sensitivity. As a considerable number of new drugs are periodically introduced into the market, the incidence of CADR is likely to increase. The pattern of CADR and the causative drugs is likely to change accordingly. Read More

Allergy Asthma Immunol Res 2019 Mar;11(2):231-240

Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Eperisone is an oral muscle relaxant used in musculoskeletal disorders causing muscle spasm and pain. For more effective pain control, eperisone is usually prescribed together with nonsteroidal anti-inflammatory drugs (NSAIDs). As such, eperisone may have been overlooked as the cause of anaphylaxis compared with NSAIDs. Read More

J Int Med Res 2019 Feb 7;47(2):1010-1014. Epub 2018 Dec 7.

1 Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Wangfujing, Beijing, China.

Cefuroxime is a second-generation cephalosporin antibiotic that causes immediate hypersensitivity reactions, ranging from mild urticaria to severe anaphylactic shock. Anaphylactic reactions typically involve multiple systems, most notably, the skin and the respiratory and cardiovascular systems. Here, we report the unusual case of a patient who presented with oral cefuroxime-induced anaphylaxis with prominent neurologic manifestations. Read More

Pediatr Dermatol 2019 Jan 26;36(1):e27-e30. Epub 2018 Nov 26.

Department of Oral Surgery and Pathology, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Drug-induced reactions are complications associated with high mortality and significant morbidity. Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are examples of these conditions, which are characterized by skin and mucous lesions. Here, we report a case of a 9-year-old girl who presented with blisters associated with an extensive vesicular rash and multiple ulcerations on the lips and oral cavity. Read More

Indian J Sex Transm Dis AIDS 2017 Jul-Dec;38(2):128-135

Department of Community Medicine, Government Villupuram Medical College and Hospital, Villupuram, Tamil Nadu, India.

Background: Mucocutaneous findings may be the presenting symptoms in HIV-afflicted individuals. A multitude of mucocutaneous diseases also occurs during the course of the ailment, with some conditions being classed as disease defining. They include infectious diseases and noninfective inflammatory and neoplastic dermatoses. Read More

Zhonghua Kou Qiang Yi Xue Za Zhi 2018 Aug;53(8):566-571

Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Chengdu 610041, China.

Chemotherapy is one of the effective methods to treat cancer. However, the chemotherapy agents may cause a series of adverse reactions due to the nonselective characteristics that affect not only tumor cells, but also normal cells. Oral mucositis induced by chemotherapy is a common oral complication caused by chemotherapy in clinic. Read More

Clujul Med 2018 15;91(1):27-36. Epub 2018 Jan 15.

Oral Medicine Department, Dental Faculty, Shahid Beheshti University of Medical Sciences, Islamic Republic of Iran.

Background: Adverse reaction to medication is common and may have a variety of clinical manifestations in the oral cavity. The present review paper aimed to describe adverse drug reactions (ADRs) which might be encountered by dental practitioners in every discipline.

Methods: In this narrative review article, the specialized databases such as PubMed, PubMed Central, MEDLINE, EBSCO, Science Direct, Scopus, and reference books from the years 2000-2016 were used to find relevant documents by using MeSH terms: Adverse Drug Reaction, Drug induced, Medication Related, Mouth, Oral Manifestation, Tooth, Hard Tissue, Soft Tissue. Read More

Int Arch Allergy Immunol 2018;175(4):237-245. Epub 2018 Jan 26.

Sabah Al Ahmed Cardiac Center, Ministry of Health, Kuwait City, Kuwait.

Background: A history of nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity with cross-intolerance to several drugs is common in some patients with coronary artery disease. We present a series of patients with acute coronary syndrome undergoing ASA desensitization prior to a possible stent to evaluate the short- and long-term efficacy and safety. The aim was to evaluate the outcomes of an ASA desensitization protocol developed by our center based on the guidelines proposed by the EAACI drug allergy expert recommendations. Read More

Hua Xi Kou Qiang Yi Xue Za Zhi 2017 Dec;35(6):625-628

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Medical Affairs, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Objective: This study aims to investigate the characteristics and general rules of adverse drug reactions (ADR) in a 3A-grade stomatology hospital for safe and rational drug use in clinical stomatology.

Methods: We retrospectively analyzed 52 ADR cases (1∶1.36, males∶females) reported in the West China Hospital of Stomatology of Sichuan University from 2014 to 2016 in terms of gender and age distributions, drug categories, and clinical manifestations. Read More

Am J Clin Dermatol 2018 Jun;19(3):345-361

Oncodermatology, Institut Claudius REGAUD and Institut Universitaire du Cancer Toulouse Oncopole, 1 avenue Irène Joliot-Curie, 31059, Toulouse Cedex 9, France.

The development of immune checkpoint inhibitors [monoclonal antibodies targeting cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), programmed cell death protein 1 (PD-1) or programmed death ligand 1 (PD-L1)] represents a major breakthrough in cancer therapy. Although they present a favorable risk/benefit ratio, immune checkpoint blockade therapies have a very specific safety profile. Due to their unique mechanism of action, they entail a new spectrum of adverse events that are mostly immune related [immune-related adverse events (irAEs)], notably mediated by the triggering of cytotoxic CD4+/CD8+ T cell activation. Read More

J Dermatol 2018 Mar 14;45(3):344-348. Epub 2017 Dec 14.

Department ofDermatology, Kansai Medical University, Hirakata, Japan.

Hydroxychloroquine (HCQ) is an effective treatment of lupus erythematosus. Although adverse effects, mainly gastrointestinal and cutaneous manifestations, are rare, they may result in the cessation of medication in some patients with severe reactions. Therefore, the evaluation of a patient's condition is important for a dermatologist to decide whether to cease or continue HCQ. Read More

Rev Iberoam Micol 2018 Jan - Mar;35(1):59-61. Epub 2017 Nov 27.

Unidad Micología, Hospital de Infecciosas F. J. Muñiz, Ciudad Autónoma de Buenos Aires, Argentina.

The case of a 60 year old woman with hemoptysis and a thin-walled cavitary lesion at the upper lobe of the right lung is presented. The woman presented at the Mycology Unit of the Muñiz Hospital in Buenos Aires City 3 months after the beginning of her clinical manifestations. A hyaline micelial fungus with chlamido-arthroconidias was isolated from the bronchoalveolar lavage. Read More

Anaesthesist 2017 Dec 8;66(12):944-947. Epub 2017 Nov 8.

Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Muenster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Münster, Germany.

We present the case of an 8‑year-old female child with suspected peroxisomal disorder requiring general anesthesia for adenotomy, paracentesis and brainstem-evoked response audiometry. Peroxisomes are small intracellular organelles that catalyse key metabolic reactions. Peroxisomal disorders are a heterogeneous group of rare genetic diseases. Read More

Am J Physiol Gastrointest Liver Physiol 2018 02 26;314(2):G231-G246. Epub 2017 Oct 26.

Hans Christian Andersen Children's Hospital, Odense University Hospital , Odense , Denmark.

Chemotherapy for cancer patients induces damaging tissue reactions along the epithelium of the gastrointestinal tract (GIT). This chemotherapy-induced mucositis (CIM) is a serious side effect of cytotoxic drugs, and several animal models of CIM have been developed, mainly in rodents and piglets, to help understand the progression of CIM and how to prevent it. Animal models allow highly controlled experimental conditions, detailed organ (e. Read More

Lupus 2018 Apr 9;27(5):703-707. Epub 2017 Oct 9.

2 Clinical Immunology, Angioedema and Allergy Unit, The Zabludowicz Center for Autoimmune Diseases, 26744 Sheba Medical Center, Tel Hashomer , Israel.

Hydroxychloroquine (HCQ) is widely used to treat autoimmune/rheumatic diseases such as systemic lupus erythematosus (SLE). The immune modulation effects of HCQ have been highlighted as beneficial for maintaining remission of SLE as well as ameliorating skin, joint and other manifestations. Moreover, HCQ exposure for prolonged periods as well as during pregnancy is considered safe, therefore it is recommended for the vast majority of SLE patients. Read More

J Allergy Clin Immunol Pract 2018 Jul - Aug;6(4):1226-1235. Epub 2017 Oct 3.

Allergy Service, Infanta Leonor University Hospital, Madrid, Spain.

Background: Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) in children are becoming a great concern. Most studies have focused on adults, with noted discrepancies observed in the classification of hypersensitivity reactions to NSAIDs in children when compared with adults.

Objective: To phenotype a group of children with hypersensitivity reactions to NSAIDs, including paracetamol, and analyze the degree of agreement with the entities reported in adults and how they fit the proposed classifications. Read More

Int J Dermatol 2017 Dec 27;56(12):1421-1424. Epub 2017 Sep 27.

Research Unit of Emerging Infectious and Tropical Diseases (URMITE), Institut de Recherche pour le Développement 198, Institut Hospitalo-Universitaire - Méditerranée Infection, Aix-Marseille University, Marseille, France.

Background: Mucocutaneous manifestations are one of the first clinical signs in patients infected with human immunodeficiency virus (HIV). To the best of our knowledge, there has been no previous study describing dermatologic manifestations in Mauritanians infected with HIV. The aim of the present study was to determine the profiles of mucocutaneous manifestations in relation to CD T cell count in HIV-positive Mauritanian patients. Read More

Clin Rev Allergy Immunol 2017 Dec;53(3):413-427

Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.

Inflammatory bowel disease (IBD) with its two main subtypes Crohn's disease and ulcerative colitis is not restricted to the gastrointestinal tract. Indeed, so-called extraintestinal manifestations (EIMs) are frequent and considerably affect morbidity and mortality. The prevalence of EIMs ranges from 6 to 47%. Read More

J Cutan Med Surg 2017 Nov/Dec;21(6):540-550. Epub 2017 Jun 22.

2 Skin Centre for Dermatology, Peterborough, ON, Canada.

Anticoagulants are amongst the most commonly prescribed medications worldwide. Although rare, localised and systemic drug reactions have been reported with anticoagulants that can lead to significant morbidity and mortality. Some of the first signs of drug reactions to anticoagulants are cutaneous changes that, when recognised early, can prevent significant complications. Read More

Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.

Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Autoimmune progesterone dermatitis (APD) is a rare disorder characterized by periodic skin lesions that erupt during the luteal phase of the menstrual cycle. Clinical manifestations of APD is caused by an unusual allergy to progesterone and has a wide range of clinical manifestations from eczema and urticaria to angioedema and erythema multiforme. A 46-year-old woman described recurrent, round erythematous plaques on the lower lip, both forearms and buttocks. Read More

Eur J Dermatol 2017 Jun;27(3):271-274

Department of Dermatology, Saint-André Hospital CHU Bordeaux, Bordeaux, France, INSERM U1053, Bordeaux Research in Translational Oncology University Bordeaux, Bordeaux, France, French Study Group of Cutaneous Lymphoma (GFELC).

Hypersensitivity reactions (HSR) to pegylated liposomal doxorubicin (PLD; Caelyx) have been reported, and symptoms usually resolve with drug withdrawal. However, the risk of relapse of severe HSR and prevention remain poorly described. To report the management and outcome in four patients with HSR due to PLD. Read More

BMC Res Notes 2017 May 8;10(1):179. Epub 2017 May 8.

Presbyterian General Hospital Acha-Tugi, Acha, Cameroon.

Background: Stevens-Johnson syndrome is one of the manifestations of mucocutaneous adverse drug reactions. Although antimicrobials are responsible for greater than 50% of these adverse drug reactions, there is no documented case implicating ivermectin as the culprit. A 38 year old adult Cameroonian male presented to our health facility with facial rash, painful oral sores, black eschars on lips and red tearing eyes 3 days following ingestion of ivermectin received during a nationwide anti-filarial campaign. Read More

Am J Clin Dermatol 2017 Aug;18(4):541-553

Department of Dermatology, University Hospital Jena, Erfurter Straße 35, 07740, Jena, Germany.

Diabetes mellitus is a widespread endocrine disease with severe impact on health systems worldwide. Increased serum glucose causes damage to a wide range of cell types, including endothelial cells, neurons, and renal cells, but also keratinocytes and fibroblasts. Skin disorders can be found in about one third of all people with diabetes and frequently occur before the diagnosis, thus playing an important role in the initial recognition of underlying disease. Read More

Chin J Traumatol 2017 Apr 21;20(2):84-86. Epub 2017 Feb 21.

Department of Neurosurgery, College of Medical Sciences, Bharatpur, Nepal.

Purpose: Despite the prevalence and cost of traumatic brain injury related disabilities, there is paucity in the literature on modern approaches to pharmacotherapy. Medications may promote recovery by enhancing some neurological functions without impacting others. Herein we discussed the role of bromocriptine in neurorehabilitation for patients with traumatic brain injury. Read More

Pediatr Dent 2017 Jan;39(1):9-14

Professor and chairperson, Departments of Pediatric Dentistry, Children's Hospital Colorado and School of Dental Medicine Delta Dental of Colorado Endowed Chair in Pediatric Dentistry, in Aurora, Colo., USA.

Stevens-Johnson syndrome (SJS) is a rare condition, characterized by its dramatic involvement of the skin and various mucosal surfaces including the oral mucosae, that severely impairs the affected patient's ability to speak, chew, or swallow. The purpose of this report was to present two cases with significant variations in the clinical presentation of Stevens-Johnson syndrome. In both situations, the patients' conditions were not immediately recognized. Read More

Best Pract Res Clin Rheumatol 2016 10 18;30(5):826-850. Epub 2016 Nov 18.

Birmingham Behçet's Syndrome Centre of Excellence, Sheldon Block, Birmingham and Midland Eye Centre, City Hospital, Dudley Road, Birmingham, B18 7QH, UK. Electronic address:

The main orofacial manifestation of the inflammatory rheumatic diseases is that of Sjögren's syndrome. In addition, there is a constellation of orofacial manifestations of the inflammatory rheumatic diseases, many of which are extra-articular with some constituting presenting signs of the underlying rheumatic disease. This review will discuss the orofacial manifestations in a variety of connective tissue diseases and will also allude to the oral adverse drug reactions that may occur as a consequence of therapy. Read More

Allergol Immunopathol (Madr) 2017 Nov - Dec;45(6):573-578. Epub 2016 Nov 17.

Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad, Caracas, Venezuela; Allergy Service, Centro Médico de Caracas, Caracas, Venezuela.

Hypersensitivity reactions to aspirin and other NSAIDs occur in individuals genetically predisposed and exhibit different clinical manifestations, especially respiratory, cutaneous, and generalised. Five different phenotypes define distinct clinical pictures: aspirin-exacerbated respiratory disease, aspirin/NSAID cutaneous disease, NSAID-induced urticaria, angio-oedema and anaphylaxis, single NSAID reactions, and delayed reactions. They are observed more frequently in middle-aged women, and in atopic individuals. Read More

BMJ Case Rep 2016 Nov 15;2016. Epub 2016 Nov 15.

Department of Pulmonary and Critical Care, University of Arizona, Tucson, Arizona, USA.

The mortality rate for Stevens-Johnson syndrome (SJS) is estimated to be ∼12% and for toxic epidermal necrolysis (TEN) it is around 30%. It continues to be a severe life-threatening drug reaction. We present a 60-year-old Caucasian man with a medical history significant for breast cancer status post mastectomy and chemotherapy with docetaxel and cyclophosphamide who presented with severe mucositis and a progressing skin rash consistent with SJS. Read More

Dermatol Ther 2017 Jan 9;30(1). Epub 2016 Oct 9.

Department of Epidemiology and Statistics, Luzhou Medical College, Luzhou, 646000, China.

Behçet's disease (BD) involves oxidative stress (OS) aggression and imbalanced oxidant/antioxidant status. Owing to its antioxidant property, allicin is proposed for treating BD. In this study, we aimed to investigate the efficacy and safety of allicin on patients with BD with mucocutaneous involvement. Read More

Oral Dis 2017 Oct 17;23(7):849-853. Epub 2016 Nov 17.

Department of Ophthalmology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark.

Pemphigoid and pemphigus diseases as well as Stevens-Johnson syndrome present as vesiculobullous disorders of the skin and may additionally involve both the oral cavity and the ocular surface. Ocular involvement ranges from mild irritation and dry eye disease to chronic conjunctivitis, symblepharon, eyelid malposition, ocular surface scarring and severe visual loss. In addition to diagnostic assessments, ophthalmologists must treat the dry eye and meibomian gland dysfunction components of these diseases using a stepladder approach, including eyelid hygiene and lubricants. Read More

Eurasian J Med 2016 Jun;48(2):107-11

Department of Dermatology, Erciyes University School of Medicine, Kayseri, Turkey.

Objective: Diagnoses of skin, mucosae, hair and nail manifestations in malignant diseases are often challenging because of life-threatening drug reactions, opportunistic infections or skin involvement of primary processes. Description of morphology, configuration and distribution of lesions is important in order to differentiate the self-healing eruptions from serious side effects of chemotherapy. There are case reports from Turkey including dermatological manifestations of malignancies and case series in adult patients but there are no published large group studies assessing all manifestations in children. Read More

Front Pharmacol 2016 20;7:215. Epub 2016 Jul 20.

Allergy Service, Infanta Leonor University Hospital Madrid, Spain.

In subjects with non-steroidal anti-inflammatory drugs (NSAIDs)- exacerbated respiratory disease (NERD) symptoms are triggered by acetyl salicylic acid (ASA) and other strong COX-1 inhibitors, and in some cases by weak COX-1 or by selective COX-2 inhibitors. The mechanism involved is related to prostaglandin pathway inhibition and leukotriene release. Subjects who react to a single NSAID and tolerate others are considered selective responders, and often present urticaria and/or angioedema and anaphylaxis (SNIUAA). Read More

Allergol Immunopathol (Madr) 2017 Jan - Feb;45(1):40-47. Epub 2016 Jul 27.

Dona Estefânia Hospital, Centro Hospitalar de Lisboa Central, Rua Jacinta Marto, 1169-045 Lisbon, Portugal; CEDOC, Respiratory Research Group, Nova Medical School, Campo dos Mártires da Pátria, 130, 1169-056 Lisbon, Portugal.

Introduction: There are rather few publications about hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAID) in the paediatric age. In this study, we aimed to assess the frequency of confirmed NSAID hypersensitivity in children with a previous reported reaction to NSAID in order to investigate the role of the drug provocation test (DPT) in the diagnostic workup and to explore the factors associated with confirmed NSAID hypersensitivity.

Methods: We conducted a retrospective analysis of the clinical files from every patient under 18 years old who attended two Portuguese paediatric allergy outpatient clinics, from January 2009 to August 2014, due to a suspected NSAID hypersensitivity. Read More

World J Gastroenterol 2016 Jul;22(25):5655-67

Miranda Muhvić-Urek, Department of Oral Medicine and Periodontology, School of Dental Medicine, University of Rijeka, 51000 Rijeka, Croatia.

The incidence of inflammatory bowel diseases (IBD) - Crohn's disease (CD) and ulcerative colitis (UC) - has been increasing on a global scale, and progressively, more gastroenterologists will be included in the diagnosis and treatment of IBD. Although IBD primarily affects the intestinal tract, extraintestinal manifestations of the disease are often apparent, including in the oral cavity, especially in CD. Specific oral manifestations in patients with CD are as follows: indurate mucosal tags, cobblestoning and mucogingivitis, deep linear ulcerations and lip swelling with vertical fissures. Read More

Indian J Dermatol Venereol Leprol 2016 Nov-Dec;82(6):626-640

Department of Dermatology, Venereology and Leprosy, Shri B. M. Patil Medical College, Hospital and Research Center, BLDE University, Vijayapur, Karnataka, India.

Anticoagulants are the cornerstone of treatment of venous thromboembolism associated with various medical conditions and surgical procedures. They act on different steps of the coagulation pathway and are broadly categorized into heparins, vitamin K antagonists, and inhibitors of thrombin and factor Xa. The classification is evolving as newer and better oral and parenteral anticoagulants are being added. Read More

Acta Dermatovenerol Croat 2016 Apr;24(1):70-2

Daška Štulhofer Buzina, MD, PhD, University Hospital Center Zagreb, Department of Dermatology and Venereology, School of Medicine University of Zagreb, Šalata 4, 10000 Zagreb, Croatia;

Dear Editor, Inhibition of the epidermal growth factor receptor (EGFR) is a new strategy in treatment of a variety of solid tumors, such as colorectal carcinoma, non-small cell lung cancer, squamous cell carcinoma of the head and neck, and pancreatic cancer (1). Cetuximab is a chimeric human-murine monoclonal antibody against EGFR. Cutaneous side effects are the most common adverse reactions occurring during epidermal growth factor receptor inhibitors (EGFRI) therapy. Read More

J Adv Pharm Technol Res 2016 Apr-Jun;7(2):64-8

Department of Restorative Sciences, Al Farabi Colleges, Riyadh, Saudi Arabia.

Drug reactions are a group of reactionary lesions generally show their manifestations in the oral cavity. The drug reactions may vary from local rashes to well-developed swellings in the oral cavity especially involving the gingiva. Most of the drug reactions are asymptomatic and commonly triggered from the active metabolite of a drug used for a long time. Read More

Curr Opin Oncol 2016 07;28(4):254-63

aDepartment of Medical Oncology and Clinical Research bDepartment of Oncodermatology cDepartment of Pathology dDepartment of Oral Medicine, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole eDepartment of Oncopneumology, Hopital Larrey, Toulouse University, Toulouse, France.

Purpose Of Review: The therapeutic use of anti-PD-1/PD-L1 antibodies (nivolumab, pembrolizumab) is rapidly increasing. Given their mechanism of action that triggers T-cell activation, these immune checkpoint inhibitors induce specific adverse events that are mostly of immunologic origin. In this way, cutaneous toxicities represent the most frequent immune-related adverse events (irAEs). Read More

Curr Oncol Rep 2016 06;18(6):35

Division of Cardiology, Department of Medicine, UCLA Medical Center, University of California at Los Angeles, Los Angeles, CA, USA.

Fluoropyrimidines-5-fluorouracil (5-FU) and capecitabine-have been implicated as cardiotoxic chemotherapy agents. This rare, albeit potentially serious toxicity has been described in nearly four decades of case reports, case series, and in vitro modeling; however, there is a paucity in clinical trials and prospective analyses focused on cardioprotective strategies and cardiotoxic surveillance of these agents. While much attention has focused on the well-known cardiac toxicity of anthracyclines and monoclonal antibody agents such as trastuzumab, fluoropyrimidines remain one of the most common causes of chemotherapy-associated cardiotoxicity. Read More

Dermatol Online J 2016 Jan 15;22(1). Epub 2016 Jan 15.

Massachusetts General Hospital.

Scurvy results from a deficiency of vitamin C, a nutrient otherwise known as ascorbic acid. Today, scurvy is rare yet emerges in select patients. The patient reported herein developed scurvy secondary to deliberate avoidance of vitamin C-rich foods. Read More

J Community Support Oncol 2016 Feb;14(2):54-65

Southern Network on Adverse Reactions (SONAR), South Carolina Center of Economic Excellence for Medication Safety, College of Pharmacy, University of South Carolina, Columbia, South Carolina, USA.

Background: The 3 fluoroquinolone (FQ) antibiotics - ciprofoxacin, levofoxacin, and moxifoxacin - are commonly administered to oncology patients. Although these oral antibiotics are approved by the US Food and Drug Administration (FDA) for treatment of urinary tract infections, acute bacterial sinusitis, or bacterial infection in patients with chronic obstructive pulmonary disease, they are commonly prescribed off-label to neutropenic cancer patients for the prevention and treatment of infections associated with febrile neutropenia. New serious FQ-associated safety concerns have been identified through novel collaborations between FQ-treated persons who have developed long-term neuropsychiatric (NP) toxicity, pharmacovigilance experts, and basic scientists. Read More

Molecules 2016 Feb 23;21(3):190. Epub 2016 Feb 23.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz 55128, Germany.

Sodium aescinate (SA) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic. To date, no toxicity or adverse events in SA have been reported, by using routine models (in vivo or in vitro), which are insufficient to predict all aspects of its pharmacological and toxicological actions. In this study, taking advantage of transparent zebrafish larvae (Danio rerio), we evaluated cardiovascular toxicity of SA at doses of 1/10 MNLC, 1/3 MNLC, MNLC and LC10 by yolk sac microinjection. Read More

Clin Exp Allergy 2016 Apr;46(4):631-9

Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Background: Histamine H2 receptor antagonists are commonly prescribed medications and are known to be well tolerated. However, 99 cases of ranitidine-induced anaphylaxis occurred in Korea from 2007 to 2014.

Objective: The purpose of this study was to determine the incidence, clinical features, and diagnostic methods for ranitidine-induced anaphylaxis. Read More

Fiziol Zh 2016;62(3):60-5

The aim of the work was to study the limbic-neocortical and monoaminergic features of the development of withdrawal syndrome of volatile organic compounds (VOC) inhalations in rats. The study was carried out in 30 three months old male rats with dependence on inhalations of organic solvent “646” which contains up to 50 % mix of toluene and acetone. It has been shown that the withdrawal syndrome of inhalant is characterized by increased excitability and behavioral manifestations of equivalents of convulsive reactions such as oral hyperkinesis, head shaking and changes in the frequencyamplitude spectrum of the biopotentials in structures of the brain limbic-neocortical system with the initiation in the medial olfactory region and hippocampus. Read More

Head Face Med 2015 Dec 28;11:38. Epub 2015 Dec 28.

Faculty of Health Sciences, University of Cape Town, Observatory, 7925, Cape Town, South Africa.

A South African girl with CANDLE Syndrome is reported with emphasis on the orodental features and dental management. Clinical manifestations included short stature, wasting of the soft tissue of the arms and legs, erythematous skin eruptions and a prominent abdomen due to hepatosplenomegaly. Generalized microdontia, confirmed by tooth measurement and osteopenia of her jaws, confirmed by digitalized radiography, were previously undescribed syndromic components. Read More

Neth J Med 2015 Dec;73(10):471-7

Internal Medicine, section Clinical Immunology, Erasmus MC, Rotterdam, the Netherlands.

Introduction: Behçet's disease is most prevalent in countries along the former Silk Road. Prevalence varies from 70-420 per 100,000 in Turkey, and 13.5-20 and 1-2 per 100,000 in Asia and Western Europe, respectively. Read More

Zhongguo Zhong Yao Za Zhi 2015 May;40(10):2037-41

With patients' general situation, medication use, occurrence time of adverse drug reaction/event (ADR/ADE), clinical manifestations and prognosis as reference items, a retrospective study was made for 315 cases with ADR/ADE induced by Gastrodin in Chongqing from January 2008 to June 2014, in order to analyze the characteristics of ADR/ADE and provide reference for rational clinical medication. The results showed that among the 315 cases with ADR/ADE, 143 cases (45.4%) were males and 172 cases (54. Read More

Ear Nose Throat J 2015 Jul;94(7):282-4

Southeastern Ear, Nose, Throat, and Sinus Center, 10071 Pines Blvd., Ste. C, Pembroke Pines, FL 33024, USA.

Sweet syndrome (acute febrile neutrophilic dermatosis) is a disorder of unknown etiology. It has been associated with autoimmune processes, malignancies, infections, drug reactions, and gastrointestinal disorders such as inflammatory bowel disease. We describe the case of a 51-year-old man who presented with severe pain in his tongue and throat and referred pain in his right ear, along with odynophagia, fever, and hoarseness of 48 hours'duration. Read More

Ann Allergy Asthma Immunol 2015 Sep 23;115(3):178-182.e3. Epub 2015 Jul 23.

Allergy & Immunology Section, Louisiana State University Health, Shreveport, Louisiana. Electronic address:

Objective: To review the literature on immediate hypersensitivity reactions to corticosteroids and classify them according to manifestations, routes of exposure, causative preparations, diagnostic tests, and management.

Data Sources: PubMed search for English-language publications from January 1, 2004 through December 31, 2014 using search terms corticosteroid, glucocorticoid, or steroid combined with hypersensitivity, allergy, or anaphylaxis.

Study Selection: Only reports of immediate hypersensitivity reactions that occurred sooner than 24 hours after administration of a corticosteroid were included. Read More