4,766 results match your criteria Oral Malignant Melanoma


Restorative biodegradable two-layered hybrid microneedles for melanoma photothermal/chemo co-therapy and wound healing.

J Nanobiotechnology 2022 May 19;20(1):238. Epub 2022 May 19.

State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China.

Tumor killing and wound healing are two complementary and influential processes during the treatment of melanoma. Herein, a two-layered microneedle platform was developed with bifunctional effect of chemo-photothermal synergistic melanoma therapy and skin regeneration. The bifunctional platform composed of embeddable curcumin nanodrugs/new Indocyanine Green/hyaluronic acid (Cur NDs/IR820/HA) microneedles and sodium alginate/gelatin/hyaluronic acid (SA/Ge/HA) supporting backing layer was prepared through a two-step casting process. Read More

View Article and Full-Text PDF

Antigen mimicry as an effective strategy to induce CSPG4-targeted immunity in dogs with oral melanoma: a veterinary trial.

J Immunother Cancer 2022 May;10(5)

Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy

Background: Melanoma is the most lethal form of skin cancer in humans. Conventional therapies have limited efficacy, and overall response is still unsatisfactory considering that immune checkpoint inhibitors induce lasting clinical responses only in a low percentage of patients. This has prompted us to develop a vaccination strategy employing the tumor antigen chondroitin sulfate proteoglycan (CSPG)4 as a target. Read More

View Article and Full-Text PDF

Acquired Compound Melanocytic Nevus on the Palate of a Child: Report of a Case.

J Oral Maxillofac Res 2022 Jan-Mar;13(1):e5. Epub 2022 Mar 31.

Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of AthensGreece.

Background: Oral melanocytic nevi are relatively rare in comparison to their cutaneous counterparts. The aim of this manuscript is to present a case of acquired compound oral melanocytic nevi on the hard palatal mucosa of a child.

Methods: A 5-year-old female girl was referred for evaluation of a pigmented lesion on the hard palate. Read More

View Article and Full-Text PDF

The significance of intratumoural CD163 macrophages in oral malignant melanoma: A preliminary study.

Oral Dis 2022 May 14. Epub 2022 May 14.

Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.

View Article and Full-Text PDF

Texture Analysis in Diagnosing Skin Pigmented Lesions in Normal and Polarized Light-A Preliminary Report.

J Clin Med 2022 Apr 29;11(9). Epub 2022 Apr 29.

Department of Maxillofacial Surgery, Medical University of Lodz, 113 S. Zeromski Street, 90-549 Lodz, Poland.

The differential diagnosis of benign nevi (BN), dysplastic nevi (DN), and melanomas (MM) represents a considerable clinical problem. These lesions are similar in clinical examination but have different prognoses and therapeutic management techniques. A texture analysis (TA) is a mathematical and statistical analysis of pixel patterns of a digital image. Read More

View Article and Full-Text PDF

Oral Etoposide and Trastuzumab Use for HER2-Positive Metastatic Breast Cancer: A Retrospective Study from the Institut Curie Hospitals.

Cancers (Basel) 2022 Apr 24;14(9). Epub 2022 Apr 24.

Department of Medical Oncology, Institut Curie, 92210 St Cloud, France.

Background: The and genes are co-amplified in about 40% of HER2 positive (HER2+) breast cancers. Oral etoposide (VP16), an inhibitor of topoisomerase-II (encoded by ), has demonstrated clinical activity in metastatic breast cancer (MBC). The benefit of oral VP16 combined with trastuzumab (VP16-T) in HER2+ MBC has not yet been evaluated. Read More

View Article and Full-Text PDF

Mucosal Melanoma of the Oral Cavity: What is the Role of Elective Neck Dissection?

Laryngoscope 2022 May 13. Epub 2022 May 13.

Department of Otolaryngology - Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, U.S.A.

Objectives: Mucosal melanoma (MM) is a rare malignancy that can present in the head and neck (H&N). The Oral cavity is the second most common primary site in the H&N after sinonasal mucosa. This study investigates the impact of demographic and clinical factors on survival in oral cavity MM. Read More

View Article and Full-Text PDF

Oral Pathology in Portuguese Dogs: An Eight-Year Biopsy-Based Retrospective Study.

J Vet Dent 2022 May 11:8987564221098107. Epub 2022 May 11.

Biopathology Unit, University Institute of Health Sciences (IUCS), 92909CESPU, Gandra, Portugal.

The oral cavity of the dog can be the site of several types of pathology including both benign and malignant lesions. The aim of this study was to analyze the frequency and clinical-pathological characteristics of oral lesions present in a cohort of Portuguese dogs. A retrospective observational cross-sectional study on 704 canine oral lesions submitted for histopathological diagnosis to a Veterinary Pathology Center in the north of Portugal from 2010 to 2017 was performed. Read More

View Article and Full-Text PDF

Long-term survival of dogs with stage 4 oral malignant melanoma treated with anti-canine PD-1 therapeutic antibody: A follow-up case report.

Vet Comp Oncol 2022 May 10. Epub 2022 May 10.

Laboratory of Molecular Diagnostics and Therapeutics, The United Graduate School of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.

A monoclonal antibody targeting programmed cell death-1 (PD-1) is one of the most promising treatments for human cancers. Clinical studies in humans demonstrated that the anti-PD-1 antibody provides a long-lasting tumour response. Previously, we established an anti-canine PD-1 therapeutic antibody (ca-4F12-E6), and the pilot clinical study demonstrated that the antibody was effective in dogs with oral malignant melanoma (OMM). Read More

View Article and Full-Text PDF

Base of tongue metastasis of cutaneous malignant melanoma with rhabdoid and neuroendocrine features: Report of a rare case and review of the literature.

Head Neck Pathol 2022 May 6. Epub 2022 May 6.

Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.

Metastatic malignant melanoma (MM) represents a highly aggressive cancer associated with overall poor prognosis. Various anatomic sites can be affected, including the oral cavity and the oropharynx. It may mimic other entities by assuming a variety of clinical appearances and exhibiting a plethora of microscopic variations. Read More

View Article and Full-Text PDF

Diagnosis and Histopathologic Prognostication of Canine Melanocytic Neoplasms: A Consensus of the Oncology-Pathology Working Group.

Vet Comp Oncol 2022 May 6. Epub 2022 May 6.

Clinical Studies, VCA, Los Angeles, CA, USA.

One of the primary objectives of the XXXX is for oncologists and pathologists to collaboratively generate consensus documents to standardize aspects of and provide guidelines for veterinary oncologic pathology. Consensus is established through review of relevant peer-reviewed literature relative to a XXX particular focus. In this article, the authors provide a critical review of the current literature for the diagnosis of, and histopathologic prognostication for, canine cutaneous and oral/lip melanocytic neoplasms, suggest guidelines for reporting, provide recommendations for clinical interpretation, and discuss future directions. Read More

View Article and Full-Text PDF

Xeroderma pigmentosum: an updated review.

Drugs Context 2022 25;11. Epub 2022 Apr 25.

Department of Paediatrics, Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong.

Background: Early recognition of xeroderma pigmentosum is important to minimize the complications arising from the harmful effects of exposure to ultraviolet radiation. This narrative review aims to familiarize physicians with the clinical features, diagnosis and management of xeroderma pigmentosum.

Methods: A search was conducted in December 2021 in PubMed Clinical Queries using the key term "xeroderma pigmentosum". Read More

View Article and Full-Text PDF

MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling.

Signal Transduct Target Ther 2022 May 4;7(1):147. Epub 2022 May 4.

Department of Thoracic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

The incidence of cutaneous melanoma (CM) has been increasing annually worldwide. In this study, we identify that MrgprF, a MAS related GPR family member, is decreased in cutaneous melanoma tissues and cell lines due to hypermethylation of its promoter region, and show that patients with CM expressing high levels of MrgprF exhibit an improved clinical outcome. We demonstrate that MrgprF forced expression inhibits tumor cell proliferation, migration, xenograft tumor growth, and metastasis. Read More

View Article and Full-Text PDF

Actionable Mutation Profile of Sun-Protected Melanomas in South America.

Am J Dermatopathol 2022 May 3. Epub 2022 May 3.

Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.

Abstract: Melanomas that arise in sun-protected sites, including acral and oral mucosal melanomas, are likely under the control of unique, specific mechanisms that lead to mutagenesis through various pathways. In this study, we examined somatic mutations in tumors by targeted sequencing using a custom Ion Ampliseq Panel, comprising hotspots of 14 genes that are frequently mutated in solid tumors. Tumor DNA was extracted from 9 formalin fixation, paraffin-embedded sun-protected melanomas (4 primary oral mucosal melanomas and 5 acral lentiginous melanomas), and we identified mutations in the NRAS, PIK3CA, EGFR, HRAS, ERBB2, and ROS1 genes. Read More

View Article and Full-Text PDF

Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria.

Nat Biomed Eng 2022 May 2. Epub 2022 May 2.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, China.

The complex gastrointestinal environment and the intestinal epithelial barrier constrain the design and effectiveness of orally administered tumour vaccines. Here we show that outer membrane vesicles (OMVs) fused to a tumour antigen and produced in the intestine by ingested genetically engineered bacteria function as effective tumour vaccines in mice. We modified Escherichia coli to express, under the control of a promoter induced by the monosaccharide arabinose, a specific tumour antigen fused with the protein cytolysin A on the surface of OMVs released by the commensal bacteria. Read More

View Article and Full-Text PDF

Head and Neck Melanoma: Where Are We Now?

Oral Maxillofac Surg Clin North Am 2022 May;34(2):xi

Division of Surgical Oncology, Division of Oral & Maxillofacial Surgery, Departmet of Surgery, Vassar Brothers Medical Center, Nuvance Health, 45 Reade Place, 3rd Floor, Dyson Center for Cancer Care, Poughkeepsie, NY 12601, USA. Electronic address:

View Article and Full-Text PDF

Future Treatments in Melanoma.

Oral Maxillofac Surg Clin North Am 2022 May;34(2):325-331

Department of Surgery, Vassar Brothers Medical Center, Nuvance Health, Dyson Center for Cancer Care, 45 Reade Place, 3rd Floor Surgical Oncology, Poughkeepsie, NY 12601, USA. Electronic address:

Melanoma is a highly malignant tumor that is relatively common in the United States. Surgical extirpation is the mainstay in treatment, but a multimodal therapeutic approach is increasingly important in the era of highly effective immune and targeted therapies. Although resection of melanoma will continue to be the mainstay of management for the conceivable future, improvements in multimodality therapy have and will continue to rewrite the therapeutic playbook for this lethal and increasingly complex malignancy for head and neck surgeons treating patients with melanoma. Read More

View Article and Full-Text PDF

Adjuvant and Neoadjuvant Therapies in Cutaneous Melanoma.

Oral Maxillofac Surg Clin North Am 2022 May;34(2):315-324

Earle A. Chiles Research Institute in the Robert W. Franz Cancer Center, Providence Cancer Institute, 4805 NE Glisan Street Suite 2N35, Portland, OR 97213, USA. Electronic address:

Melanoma is the most common cause of skin cancer-related death in the United States. Cutaneous melanoma is most prevalent in the head and neck. The long-term prognosis has been poor and chemotherapy is not curative. Read More

View Article and Full-Text PDF

Reconstruction of Head and Neck Melanoma Defects.

Oral Maxillofac Surg Clin North Am 2022 May;34(2):283-298

Department of Surgery, Vassar Brothers Medical Center, Nuvance Health, 45 Reade Place, GME, 4th Floor, Poughkeepsie, NY 12601, USA.

The head and neck region is unique from the other anatomic sites due to its rich blood supply and ability to heal well after surgery. Surgical extirpation of melanoma usually requires wide resection margins, and the defect from surgery can be devastating to the patient and impossible to conceal sometimes. Therefore, the goal of a reconstructive technique is to restore the uniformity of skin color, texture, and contour and preserve the function. Read More

View Article and Full-Text PDF

Classification and Staging of Melanoma in the Head and Neck.

Oral Maxillofac Surg Clin North Am 2022 May;34(2):221-234

Division of Head and Neck Surgery, Department of Oral and Maxillofacial Surgery, University of Florida College of Medicine,- Jacksonville 653-1 West 8th, Street, Jacksonville, FL 32209, USA.

The rates of melanoma continue to rise, with recent estimates have shown that 18% to 22% of new melanoma cases occur within the head and neck in the United States each year. The mainstay of treatment of nonmetastatic primary melanomas of the head and neck includes the surgical resection and management of regional disease as indicated. Thorough knowledge of the classification and staging of melanoma is paramount to evaluate prognosis, determine the appropriate surgical intervention, and assess eligibility for adjuvant therapy and clinic trials. Read More

View Article and Full-Text PDF

Introduction to Head and Neck Melanoma: A Dermatologist's Perspective.

Oral Maxillofac Surg Clin North Am 2022 May;34(2):213-220

Caremount Medical, Poughkeepsie, NY, USA.

Melanoma is often initially evaluated by the dermatologist. A methodical evaluation requires complete history and detailed clinical physical examination and appropriate decisions regarding biopsies. Accurate diagnosis and staging require clinicopathologic correlation and an excellent relationship with the dermatopathologist. Read More

View Article and Full-Text PDF

Recent development of Proniosomal Transdermal drug delivery: an Overview.

Curr Drug Deliv 2022 Apr 22. Epub 2022 Apr 22.

Department of Pharmaceutics, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur- 440037, Maharashtra, India.

Proniosomes are the stable carriers used for Transdermal application as compared to other vesicular delivery systems like niosomes and liposomes. Oral administration of a drug is associated severe GIT irritation and first pass metabolism. Vesicular drug delivery system includes basic concept of niosomes and proniosomes which describe their mechanism of action, structural formation, interactive study with skin, composition, method of preparation. Read More

View Article and Full-Text PDF

Anti-melanoma Differentiation-Associated Gene 5 (Anti-MDA5) Dermatomyositis: A Case Presentation.

Cureus 2022 Mar 12;14(3):e23102. Epub 2022 Mar 12.

Rheumatology, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.

We present a case of anti-melanoma differentiation-associated gene 5 (Anti-MDA5) dermatomyositis (DM) in a 30-year-old female. Anti-MDA5 dermatomyositis, previously termed clinically amyopathic dermatomyositis, was first recognized in 2005. Most cases present with varying combinations of cutaneous and oral ulcerations, palmar papules, respiratory symptoms, and minor muscle involvement (most commonly in the shoulders, upper arms, hips, thighs, and neck). Read More

View Article and Full-Text PDF

Macrophage and T-Cell Infiltration and Topographic Immune Cell Distribution in Non-Melanoma Skin Cancer of the Head and Neck.

Front Oncol 2022 7;12:809687. Epub 2022 Apr 7.

Department for Oral and Maxillofacial Surgery, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Bavaria, Germany.

Non-melanoma skin cancer (NMSC) is a heterogeneous tumor entity that is vastly determined by age and UV-light exposure leading to a great mutational burden in cancer cells. However, the success of immune checkpoint blockade in advanced NMSC and the incidence and disease control rates of NMSC in organ transplant recipients compared to immunologically uncompromised patients point toward the emerging importance of the immunologic activity of NMSC. To gain first insight into the role of T-cell and macrophage infiltration in NMSC of the head and neck and capture their different immunogenic profiles, which appear to be highly relevant for the response to immunotherapy, we conducted a whole slide analysis of 107 basal cell carcinoma (BCC) samples and 117 cutaneous squamous cell carcinoma (cSCC) samples. Read More

View Article and Full-Text PDF

Low doses of niclosamide and quinacrine combination yields synergistic effect in melanoma via activating autophagy-mediated p53-dependent apoptosis.

Transl Oncol 2022 Apr 20;21:101425. Epub 2022 Apr 20.

Central Laboratory, Peking University School and Hospital of Stomatology, No.22, Zhongguancun Avenue South, Haidian District, Beijing 100081, China; Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, No.22, Zhongguancun Avenue South, Haidian District, Beijing 100081, China. Electronic address:

Malignant melanoma is a highly aggressive, malignant, and drug-resistant tumor. It lacks an efficient treatment approach. In this study, we developed a novel anti-melanoma strategy by using anti-tapeworm drug niclosamide and anti-malarial drug quinacrine, and investigated the molecular mechanism by in vitro and in vivo assays. Read More

View Article and Full-Text PDF

Probiotic-derived heptelidic acid exerts antitumor effects on extraintestinal melanoma through glyceraldehyde-3-phosphate dehydrogenase activity control.

BMC Microbiol 2022 04 22;22(1):110. Epub 2022 Apr 22.

Division of Metabolism and Biosystemic Science, Gastroenterology, and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, 078-8510, Japan.

Background: Several microorganisms inhabit the mammalian gastrointestinal tract and are associated with the pathogenesis of various diseases, including cancer. Recent studies have indicated that several probiotics produce antitumor molecules and inhibit host tumor progression. We demonstrated that heptelidic acid (HA), a sesquiterpene lactone derived from the probiotic Aspergillus oryzae, exerts antitumor effects against pancreatic cancer in vitro and in vivo. Read More

View Article and Full-Text PDF

Laser Therapy for the Treatment of Actinic Cheilitis: A Systematic Review.

Int J Environ Res Public Health 2022 04 11;19(8). Epub 2022 Apr 11.

Dermatology Department, Hospital Universitario San Cecilio, 18200 Granada, Spain.

Actinic cheilitis (AC) is a chronic inflammation of the lip considered an oral, potentially malignant disorder associated with an increased risk of lip squamous cell carcinoma (SCC) development. Controversies surrounding current therapeutic modalities of AC are under debate, and the implications of laser treatment have not been specifically investigated through a systematic review design. The present study aims to evaluate the degree of evidence of laser for the treatment of AC in terms of efficacy and safety. Read More

View Article and Full-Text PDF

Diagnosis and Prognosis of Canine Melanocytic Neoplasms.

Vet Sci 2022 Apr 6;9(4). Epub 2022 Apr 6.

Veterinary Diagnostic Laboratory, Michigan State University, Lansing, MI 48910, USA.

Canine melanocytic neoplasms have a highly variable biological behavior ranging from benign cutaneous melanocytomas to malignant oral melanomas that readily metastasize to lymph nodes and internal organs. This review focuses on the diagnosis and prognosis of canine melanocytic neoplasms. While pigmented melanocytic neoplasms can be diagnosed with fine-needle aspirates, an accurate prognosis requires surgical biopsy. Read More

View Article and Full-Text PDF

Managing stage 4 ameloblastoma with dual BRAF/MEK inhibition: A case report with 8-year clinical follow-up.

Oral Oncol 2022 May 18;128:105854. Epub 2022 Apr 18.

Departments of Medicine, University of Florida College of Medicine, Gainesville, FL, United States. Electronic address:

We present 8-year follow-up on the first patient with stage 4 ameloblastoma carrying a BRAF V600E mutation treated with dual BRAF/MEK inhibition (BRAF/MEKi). He experienced a durable clinical response while on dabrafenib (BRAFi) and trametinib (MEKi) without toxicity nor evidence for drug-resistant tumor progression. He was asymptomatic when he self-discontinued therapy after 4 years of sustained clinical response. Read More

View Article and Full-Text PDF