4,179 results match your criteria Oral Malignant Melanoma


Advanced Merkel Cell Carcinoma - A Focus on Medical Drug Therapy.

Dermatol Ther 2020 May 23:e13675. Epub 2020 May 23.

Dermatology Department, University Hospital of Coimbra, Praceta Mota Pinto, 3000-075, Coimbra, Portugal.

Merkel cell carcinoma (MCC) is a rare but aggressive non-melanoma skin cancer with significant morbidity and mortality. Treatment of choice for primary and locoregional MCC is complete surgical removal with sentinel lymphonodectomy and post-surgical radiotherapy of tumor basin and locoregional lymph nodes. In non-resectable and advanced tumors, drug therapy is indicated. Read More

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http://dx.doi.org/10.1111/dth.13675DOI Listing

Malignant melanoma in situ of the palate: Radical treatment or "watch and wait"?

Oral Oncol 2020 May 20:104805. Epub 2020 May 20.

Department of Histopathology, Queen Victoria Hospital NHSF Trust, Holtye Road, East Grinstead RH19 3DZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2020.104805DOI Listing

Curcumin Encapsulated Lecithin Nanoemulsions: An Oral Platform for Ultrasound Mediated Spatiotemporal Delivery of Curcumin to the Tumor.

Sci Rep 2020 May 22;10(1):8587. Epub 2020 May 22.

Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.

Systemic toxicity caused by conventional chemotherapy is often regarded as one of the major challenges in the treatment of cancer. Over years, the trigger-based modality has gained much attention as it holds the spatiotemporal control over release and internalization of the drug. In this article, we are reporting an increase in the anti-tumor efficacy of curcumin due to ultrasound pulses. Read More

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http://dx.doi.org/10.1038/s41598-020-65468-1DOI Listing

Human genetic dissection of papillomavirus-driven diseases: new insight into their pathogenesis.

Authors:
Vivien Béziat

Hum Genet 2020 May 20. Epub 2020 May 20.

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-1163, Necker Hospital for Sick Children, Paris, EU, France.

Human papillomaviruses (HPVs) infect mucosal or cutaneous stratified epithelia. There are 5 genera and more than 200 types of HPV, each with a specific tropism and virulence. HPV infections are typically asymptomatic or result in benign tumors, which may be disseminated or persistent in rare cases, but a few oncogenic HPVs can cause cancers. Read More

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http://dx.doi.org/10.1007/s00439-020-02183-xDOI Listing

Predicting STAT1 as a prognostic marker in patients with solid cancer.

Ther Adv Med Oncol 2020 8;12:1758835920917558. Epub 2020 May 8.

Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, 1508 Longhang Road, Shanghai, 201508, P.R. China.

Background: Aberrant activities of signal transducer and activator of transcription 1 (STAT1) have been implicated in cancer development. However, the prognostic value of STAT1 remains unclear. This report identified the role of STAT1 in prognosis in patients with solid cancer through open literature and The Cancer Genome Atlas (TCGA) database. Read More

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http://dx.doi.org/10.1177/1758835920917558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222261PMC

Aggressiveness potential of spontaneous canine mucosal melanoma can dictate distinct cancer stem cell compartment behaviors in regard to their initial size and expansion abilities.

Stem Cells Dev 2020 May 18. Epub 2020 May 18.

Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR 9020, UMR-S 1277 - Canther - Cancer Hetero-geneity, Plasticity and Resistance to Therapies, F-59000 Lille, France;

Mucosal melanoma represents one of the most highly metastatic and aggressive subtypes of melanoma. The biology of mucosal melanoma is poorly documented, and the lack of experimental models makes it difficult to design and test new therapies. Dogs are frequently affected by melanomas of the oral cavity, making spontaneous canine melanoma a potentially predictable model for their human counterpart. Read More

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http://dx.doi.org/10.1089/scd.2019.0223DOI Listing

Discovery of indoximod prodrugs and characterization of clinical candidate NLG802.

Eur J Med Chem 2020 May 1;198:112373. Epub 2020 May 1.

NewLink Genetics, Ames, IA, 50010, United States.

A series of different prodrugs of indoximod, including estesrs and peptide amides were synthesized with the aim of improving its oral bioavailability in humans. The pharmacokinetics of prodrugs that were stable in buffers, plasma and simulated gastric and intestinal fluids was first assessed in rats after oral dosing in solution or in capsule formulation. Two prodrugs that produced the highest exposure to indoximod in rats were further tested in Cynomolgus monkeys, a species in which indoximod has oral bioavailability of 6-10% and an equivalent dose-dependent exposure profile as humans. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112373DOI Listing
May 2020
3.447 Impact Factor

Medication-related osteonecrosis of the jaw related to epacadostat and pembrolizumab.

J Stomatol Oral Maxillofac Surg 2020 May 13. Epub 2020 May 13.

Department of oral and maxillo-facial surgery, 1200 Brussels, Belgium; Institut Roi Albert II, Cancérologie et Hématologie, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, avenue Hippocrate, 10, 1200 Brussels, Belgium. Electronic address:

MRONJ is a well-known side effect of various medications, such as antiresorptive drugs, anti-angiogenic agents, immunomodulators and immunosuppressants. MRONJ related to immunotherapy is rarely described, with only one case related to ipilimumab. The interaction between the immune system and osteoclast lineage cells is well known. Read More

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http://dx.doi.org/10.1016/j.jormas.2020.05.001DOI Listing

Speed Rate (SR) as a new dynamic index of melanoma behavior.

Pigment Cell Melanoma Res 2020 May 14. Epub 2020 May 14.

Dermatologic Clinic, Department of Medicine and Aging Science, University G D'Annunzio Chieti-Pescara, Italy.

Melanomas are skin tumors that show a variety of biological behavior. Some develop very fast and some other grow extremely slow, with metastasis appearing, eventually, many years after the diagnosis. The number of mitoses in primary melanoma has been related to a more aggressive tumor and may have a potential as predictive factor for cutaneous melanoma survival. Read More

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http://dx.doi.org/10.1111/pcmr.12890DOI Listing

Relative survival in early-stage cancers in the Netherlands: a population-based study.

J Hematol Oncol 2020 May 12;13(1):49. Epub 2020 May 12.

Department of Registration, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands.

In this nationwide, population-based study, we assessed 10-year relative survival among 225,305 patients with ten early-stage cancers diagnosed in the Netherlands during 2004-2015. This study aimed to ascertain which early-stage cancer is associated with minimal or no excess mortality and likely to be diagnosed in individuals who are otherwise more healthy or health-conscious than their counterparts in the general population. Ten-year relative survival marginally exceeded 100% in patients with early-stage prostate cancer, while it was close to 100% for patients with ductal carcinoma in situ (DCIS) and stage I cancers of the breast, skin (melanoma), testis, and thyroid. Read More

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http://dx.doi.org/10.1186/s13045-020-00888-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216409PMC

Hypertrophic lichenoid dermatitis immune-related adverse event during combined immune checkpoint and exportin inhibitor therapy: A diagnostic pitfall for superficially invasive squamous cell carcinoma.

J Cutan Pathol 2020 May 12. Epub 2020 May 12.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Immune checkpoint inhibitors (ICIs) for cancer treatment has revolutionized the field of medicine. However, an unintended but frequent consequence of ICI therapy is the development of cutaneous immune-related adverse events (irAEs), such as lichenoid dermatitis irAEs (LD-irAEs). The hypertrophic variant of LD-irAE may be a diagnostic challenge since it can mimic superficially invasive squamous cell carcinoma (SCC). Read More

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http://dx.doi.org/10.1111/cup.13739DOI Listing

5-aminolevulinic-acid-mediated sonodynamic therapy improves the prognosis of melanoma by inhibiting survivin expression.

Cancer Biomark 2020 Apr 26. Epub 2020 Apr 26.

Department of Oral Medicine, Jining Medical College, Shandong, China.

Background: This study aimed to evaluate the relationship between survivin expression and tumor after 5-aminolevulinic acid (5-ALA)-mediated sonodynamic therapy.

Methods: Immunohistochemistry was used to detect survivin protein expression in human melanoma clinical samples. Subsequently, the effects of 5-ALA-mediated sonodynamic therapy were determined by measuring the volume of melanoma xenografts and the bodyweights of melanoma-bearing nude mice. Read More

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http://dx.doi.org/10.3233/CBM-190681DOI Listing

Delayed Onset Scleromalacia and Conjunctival Bleb Formation Following Intraoperative Mitomycin C Application during Conjunctival Melanoma Excision.

Vision (Basel) 2020 May 6;4(2). Epub 2020 May 6.

Sussex Eye Hospital, Brighton & Sussex University Hospitals NHS Trust, Eastern Road, Brighton BN2 5BF, UK.

Purpose: To present a case of delayed onset scleromalacia and conjunctival bleb formation one year after conjunctival melanoma excision with intraoperative use of mitomycin-C (MMC) and double-freeze-thaw technique.

Methods: Case report.

Results: A 69-year-old woman had a conjunctival melanoma excised by the 'no touch technique' with intraoperative application of 0. Read More

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http://dx.doi.org/10.3390/vision4020024DOI Listing

Characterization of the immune profile of oral tongue squamous cell carcinomas with advancing disease.

Cancer Med 2020 May 8. Epub 2020 May 8.

Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

We investigated whether a unique immune response was instigated with the development of oral tongue squamous cell carcinomas (OTSCC), with/without nodal involvement, with/without recurrent metastatic disease, or within tumor involved nodes. One hundred and ten formalin-fixed paraffin-embedded samples were collected from a retrospective cohort of 67 OTSCC patients and 10 non-cancerous tongue samples. Targets including CD4, CD8, FOXP3, PD-L1, and PD-1 were analyzed by immunohistochemistry. Read More

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http://dx.doi.org/10.1002/cam4.3106DOI Listing

Potential mechanisms of cancer prevention by nicotinamide.

Br J Pharmacol 2020 May 7. Epub 2020 May 7.

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.

Nicotinamide (NAM) is a precursor of vitamin B commonly sold over the counter as nutritional supplement with antiaging properties. Accumulating preclinical evidence indicates that NAM also mediates oncopreventive effects against a variety of neoplasms. Supporting the translational relevance of dietary NAM supplementation, results from a Phase 3 randomized clinical trial demonstrate that oral NAM is safe and efficiently reduce the incidence of new non-melanoma skin cancers and actinic keratosis amongst high-risk individuals. Read More

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http://dx.doi.org/10.1111/bph.15096DOI Listing

Primary amelanotic melanoma of the mandibular gingiva.

Arch Craniofac Surg 2020 Apr 20;21(2):132-136. Epub 2020 Apr 20.

Departments of Pathology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

Oral mucosal melanoma is a very rare type of malignant melanoma, the characteristics of which differ from those of cutaneous melanoma. Primary amelanotic melanoma of the mandibular gingiva, which can invade the mandibular bone, is very rare worldwide. Here, we report a case in which we performed a reconstruction of the mandible and gingiva using the fibula osteocutaneous free flap procedure to treat a patient diagnosed with a primary amelanotic melanoma of the mandibular gingiva. Read More

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http://dx.doi.org/10.7181/acfs.2019.00633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206460PMC

Strategies To Improve Ellagic Acid Bioavailability: From Natural Or Semisynthetic Derivatives To Nanotechnological Approaches Based On Innovative Carriers.

Nanotechnology 2020 May 7. Epub 2020 May 7.

Engineering Department, University of Rome Niccolò Cusano, Via don Carlo Gnocchi 3, Rome, Italy, 00166, ITALY.

Ellagic acid (EA) is a polyphenolic compound whose dietary consumption is mainly associated with the intake of red fruits, including pomegranates, strawberries, blackberries, blackcurrant, raspberries, grapes or dried fruits, like walnuts and almonds. A number of studies indicate that EA exerts health-beneficial effects against several chronic pathologies associated to oxidative damage, among which different kinds of cancer, cardiovascular and neurodegenerative diseases. Furthermore, EA possesses wound healing properties, antibacterial and antiviral effects and acts as a systemic antioxidant. Read More

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http://dx.doi.org/10.1088/1361-6528/ab912cDOI Listing

Up-Regulation of Activating Transcription Factor 3 in Human Fibroblasts Inhibits Melanoma Cell Growth and Migration Through a Paracrine Pathway.

Front Oncol 2020 21;10:624. Epub 2020 Apr 21.

Department of Tissue Engineering and Regeneration, School and Hospital of Stomatology, Shandong University, Jinan, China.

The treatment of melanoma has remained a difficult challenge. Targeting the tumor stroma has recently attracted attention for developing novel strategies for melanoma therapy. Activating transcription factor 3 (ATF3) plays a crucial role in regulating tumorigenesis and development, but whether the expression of ATF3 in human dermal fibroblasts (HDFs) can affect melanoma development hasn't been studied. Read More

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http://dx.doi.org/10.3389/fonc.2020.00624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187895PMC

Tumor size as a predictor of lymphatic invasion in oral melanomas of dogs.

J Am Vet Med Assoc 2020 May;256(10):1123-1128

Objective: To investigate putative associations between oral melanoma size and variables of histologic grade such as mitotic index, nuclear atypia, junctional activity, ulceration, lymphatic invasion, and degree of pigmentation.

Sample: 59 samples of oral melanomas from dogs sourced from 6 diagnostic laboratories within Australia.

Procedures: The size of each melanoma was microscopically measured, and each sample was evaluated for variables of histologic grade including mitotic index, nuclear atypia, junctional activity, ulceration, lymphatic invasion, and degree of pigmentation by a veterinary pathologist. Read More

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http://dx.doi.org/10.2460/javma.256.10.1123DOI Listing

Biodegradable β-Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water-Insoluble Drug.

Adv Healthc Mater 2020 May 4:e2000527. Epub 2020 May 4.

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Transdermal delivery of water-insoluble drugs via hydrogel-based microneedle (MN) arrays is crucial for improving their therapeutic efficacies. However, direct loading of water-insoluble drug into hydrophilic matrices remains challenging. Here, a biodegradable MN array patch that is fabricated from naturally derived polymer conjugates of gelatin methacryloyl and β-cyclodextrin (GelMA-β-CD) is reported. Read More

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http://dx.doi.org/10.1002/adhm.202000527DOI Listing
May 2020
4.880 Impact Factor

Dietary supplements in dermatology: a review of the evidence for zinc, biotin, vitamin D, nicotinamide, and polypodium.

J Am Acad Dermatol 2020 Apr 29. Epub 2020 Apr 29.

Department of Dermatology, Johns Hopkins University, Baltimore, MD. Electronic address:

Dietary supplements are commonly recommended by dermatologists in the treatment of skin, hair, and nail disorders. This review of oral over the counter (OTC) supplement use in dermatology summarizes current evidence for the use of zinc, biotin, vitamin D, nicotinamide, and polypodium in the management of common dermatologic disorders. Evidence for the safety and efficacy of these supplements is limited. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.04.123DOI Listing

Chemopreventive effect of pomegranate and cocoa extracts on ultraviolet radiation-induced photocarcinogenesis in SKH-1 mice.

PLoS One 2020 30;15(4):e0232009. Epub 2020 Apr 30.

Department of Dermatology, Stomatology, Radiology and Physic Medicine, Faculty of Medicine, Campus of Excellence Mare Nostrum, University of Murcia, Murcia, Spain.

Non-melanoma skin cancer (NMSC) has a high and increasing incidence all over the world. Solar radiation is the main aetiology for humans. Although most research into photocarcinogenesis uses UVB as a source of radiation, UVA is also carcinogenic in long term. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232009PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192448PMC

Canine tonsillar neoplasia and tonsillar metastasis from various primary neoplasms.

Vet Comp Oncol 2020 Apr 30. Epub 2020 Apr 30.

Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado, USA.

Tonsillar metastasis from distant primary tumours has not been described in dogs, and reports are rare in humans. The aims of this study were to determine whether tumour metastasis occurs to the canine palatine tonsils and evaluate whether afferent lymphatics drain to the palatine tonsils via skull indirect computed tomography lymphangiography (ICTL). Retrospective review of the diagnostic laboratory tonsillar histopathology submissions was performed. Read More

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http://dx.doi.org/10.1111/vco.12604DOI Listing

Molecular Diagnostic of Solid Tumor Using a Next Generation Sequencing Custom-Designed Multi-Gene Panel.

Diagnostics (Basel) 2020 Apr 23;10(4). Epub 2020 Apr 23.

Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale), Molecular Diagnostic Unit, University of Bologna, Azienda USL di Bologna, viale Ercolani 4/2, 40138 Bologna, Italy.

Next generation sequencing (NGS) allows parallel sequencing of multiple genes at a very high depth of coverage. The need to analyze a variety of targets for diagnostic/prognostic/predictive purposes requires multi-gene characterization. Multi-gene panels are becoming standard approaches for the molecular analysis of solid lesions. Read More

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http://dx.doi.org/10.3390/diagnostics10040250DOI Listing

Complexation with β-cyclodextrin enhances apoptosis-mediated cytotoxic effect of harman in chemoresistant BRAF-mutated melanoma cells.

Eur J Pharm Sci 2020 Apr 23;150:105353. Epub 2020 Apr 23.

NEPLAME, Universidade Federal do Vale do São Francisco, Petrolina-PE, 56306-000, Brazil. Electronic address:

Harman, a natural β-carboline alkaloid, has recently gained considerable interest due to its anticancer properties. However, its physicochemical characteristics and poor oral bioavailability have been limiting factors for its pharmaceutical development. In this paper, we described the complexation of harman (HAR) with β-cyclodextrin (βCD) as a promising alternative to improve its solubility and consequently its cytotoxic effect in chemoresistant melanoma cells (A2058 cell line). Read More

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http://dx.doi.org/10.1016/j.ejps.2020.105353DOI Listing

Potential Drug Interactions between Recombinant Interleukin-2 and Direct Oral Anticoagulants: Indirect Evidence from In Vivo Animal Studies.

Hamostaseologie 2020 Apr 23. Epub 2020 Apr 23.

Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany.

Recombinant interleukin-2 (rIL-2) is indicated for metastatic renal cell carcinoma and melanoma. Over recent years low-dose rIL-2 has been studied for the treatment of autoimmune diseases and acute coronary syndrome because of its ability to expand and activate T regulatory (T) cells. However, several medical conditions potentially benefiting from rIL-2 administrations are characterized by an intrinsic prothrombotic risk, thus requiring concurrent anticoagulation. Read More

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http://dx.doi.org/10.1055/a-1120-4064DOI Listing
April 2020
1.589 Impact Factor

Multimodality treatment including ONCEPT for canine oral melanoma: A retrospective analysis of 131 dogs.

Vet Radiol Ultrasound 2020 Apr 22. Epub 2020 Apr 22.

Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin.

Canine oral melanoma (OM) is an aggressive cancer with a high rate of metastasis. Surgery and/or radiotherapy (RT) are effective local treatments, yet many dogs succumb to distant metastasis. Immunotherapy represents an attractive strategy for this potentially immunogenic tumor. Read More

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http://dx.doi.org/10.1111/vru.12860DOI Listing

Cyclooxygenase-2 expression is associated with infiltration of inflammatory cells in oral and skin canine melanomas.

Vet Comp Oncol 2020 Apr 23. Epub 2020 Apr 23.

Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Melanoma is a fast-growing tumour in dogs and represents 7% of the total malignant neoplasms from the skin and is the most common tumour found in the oral cavity. In these tumours, high expression of cyclooxygenase-2 (COX-2) is associated with a poor prognosis. The aim of this study was to verify if the overexpression of COX-2 is related to the modulation of lymphocytes and if it is associated with the angiogenic and proliferative capacity of the melanoma. Read More

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http://dx.doi.org/10.1111/vco.12601DOI Listing

Spatial clusters of cancer incidence: analyzing 1940 census data linked to 1966-2017 cancer records.

Cancer Causes Control 2020 Apr 22. Epub 2020 Apr 22.

Population Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.

Purpose: A life course perspective to cancer incidence is important for understanding effects of the environment during early life on later cancer risk. We assessed spatial clusters of cancer incidence based on early life location defined as 1940 US Census Enumeration District (ED).

Methods: A cohort of 260,585 individuals aged 0-40 years in 1940 was selected. Read More

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http://dx.doi.org/10.1007/s10552-020-01302-3DOI Listing

Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma.

Int J Oncol 2020 May 20;56(5):1093-1100. Epub 2020 Feb 20.

Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Nara 634‑8521, Japan.

Mast cells (MCs) are present in the tumor stroma, and MCs that express the mast cell‑specific proteases tryptase and chymase (MCTC) exhibit several tumor‑related functions. It was previously reported that melanoma inhibitory activity (MIA) gene family members, including MIA, MIA2, and transport and Golgi organization protein 1 (TANGO), possess oncogenic functions in oral squamous cell carcinoma (OSCC). However, the relationships between MCTC, and clinicopathological characteristics and activation of the MIA gene family in OSCC remain unknown. Read More

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http://dx.doi.org/10.3892/ijo.2020.4996DOI Listing

Isolated adrenocorticotrophic hormone deficiency in a patient treated with checkpoint inhibitor therapy.

Proc (Bayl Univ Med Cent) 2020 Apr 23;33(2):251-253. Epub 2019 Dec 23.

Department of Oncology, Baylor University Medical CenterDallasTexas.

Treatment of advanced melanoma has significantly improved with the advent of checkpoint inhibitor therapy. With the widespread use of these agents, side effects are being increasingly recognized, including immune-related adverse events. We report the onset of adrenal insufficiency in a patient with advanced melanoma who was exposed to two checkpoint inhibitors: ipilimumab and nivolumab. Read More

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http://dx.doi.org/10.1080/08998280.2019.1698217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155976PMC

Electric field and air ion exposures near high voltage overhead power lines and adult cancers: a case control study across England and Wales.

Int J Epidemiol 2020 Apr;49(Supplement_1):i57-i66

UK Small Area Health Statistics Unit, MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.

Background: Various mechanisms have been postulated to explain how electric fields emitted by high voltage overhead power lines, and the charged ions they produce, might be associated with possible adult cancer risk, but this has not previously been systematically explored in large scale epidemiological research.

Methods: We investigated risks of adult cancers in relation to modelled air ion density (per cm3) within 600 m (focusing analysis on mouth, lung, respiratory), and calculated electric field within 25 m (focusing analysis on non-melanoma skin), of high voltage overhead power lines in England and Wales, 1974-2008.

Results: With adjustment for age, sex, deprivation and rurality, odds ratios (OR) in the highest fifth of net air ion density (0. Read More

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http://dx.doi.org/10.1093/ije/dyz275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158064PMC

Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction.

Nat Commun 2020 Apr 14;11(1):1833. Epub 2020 Apr 14.

Department of Pathology, Yale School of Medicine, New Haven, CT, 06520, USA.

Small molecule inhibitor of the bromodomain and extraterminal domain (BET) family proteins is a promising option for cancer treatment. However, current BET inhibitors are limited by their potency or oral bioavailability. Here we report the discovery and characterization of NHWD-870, a BET inhibitor that is more potent than three major clinical stage BET inhibitors BMS-986158, OTX-015, and GSK-525762. Read More

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http://dx.doi.org/10.1038/s41467-020-15290-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156724PMC
April 2020
10.742 Impact Factor

Detectability of fluorescent gold nanoparticles under micro-CT and optical projection tomography imaging.

J Med Imaging (Bellingham) 2020 Mar 6;7(2):026002. Epub 2020 Apr 6.

The University of British Columbia, Department of Oral Biological and Medical Sciences, Vancouver, British Columbia, Canada.

Preclinical studies often compare micro-computed tomography (micro-CT) imaging with histology using optical microscopy of fluorescently labeled slides. However, correlating the images is difficult because the tissues appear differently in the two modalities. It would be valuable to have a single contrast medium visible on both radiographic and optical imaging. Read More

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http://dx.doi.org/10.1117/1.JMI.7.2.026002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134614PMC

Reconstruction of an upper lip and intraoral defect following resection of an upper lip melanoma using a lower lip musculomucosal flap combined with a tongue flap.

J Surg Case Rep 2020 Apr 7;2020(4):rjaa072. Epub 2020 Apr 7.

Department of Molecular Oral Medicine and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Restoring the cosmetic and functional aspects of the lip after tumor resection is challenging. We report a case of reconstruction for a defect due to resection of a melanoma using a lower lip musculomucosal flap combined with a tongue flap. A 20-year-old man was referred to our hospital and diagnosed with malignant melanoma with metastatic right submaxillary lymph nodes. Read More

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http://dx.doi.org/10.1093/jscr/rjaa072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136836PMC

ZEB and Snail expression indicates epithelial-mesenchymal transition in canine melanoma.

Res Vet Sci 2020 Apr 6;131:7-14. Epub 2020 Apr 6.

Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, MG, Brazil. Electronic address:

Melanoma progression is associated with the epithelial-mesenchymal transition (EMT) when tumor cells reduce E-cadherin and increase N-cadherin expression resulting in an escape from the microenvironment via loss of cellular adhesion and gain of motility. Transcription factor proteins Snail and ZEB trigger EMT by repression of epithelial markers and activation of mesenchymal properties. This study evaluated E-cadherin, N-cadherin, Snail, ZEB1 and ZEB2 expression by IHC and investigated their relationship with morphological characteristics in cutaneous and oral canine melanoma. Read More

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http://dx.doi.org/10.1016/j.rvsc.2020.04.007DOI Listing

Knockdown of ectodysplasin-A receptor-associated adaptor protein exerts a tumor-suppressive effect in tongue squamous cell carcinoma cells.

Exp Ther Med 2020 May 6;19(5):3337-3347. Epub 2020 Mar 6.

Department of Stomatology, Central Hospital of Xuzhou, The Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu 221000, P.R. China.

Tongue squamous cell carcinoma (TSCC) is a common malignancy in oral cancer with a high mortality and morbidity. The ectodysplasin-A receptor-associated adaptor protein (EDARADD) is a death domain-containing adaptor protein that interacts with the TNF family ligand ectodysplasin A receptor. It is known that EDARADD has an effect on the development of ectodermal derivative tissues, such as hair and teeth. Read More

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http://dx.doi.org/10.3892/etm.2020.8578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132229PMC

The discovery and development of binimetinib for the treatment of melanoma.

Expert Opin Drug Discov 2020 Apr 4:1-10. Epub 2020 Apr 4.

Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA.

: Binimetinib is an uncompetitive, small-molecule inhibitor of selective mitogen-activated protein kinase (1/2) and was recently approved in 2018 in combination with encorafenib for the treatment of metastatic melanomas. Preclinical and clinical trial data on the drug demonstrate its potent efficacy in cancers, especially melanomas with and mutations.: The authors review the preclinical as well as clinical Phase 1, 2 and 3 trial data leading to its FDA approval in 2018 for metastatic melanoma. Read More

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http://dx.doi.org/10.1080/17460441.2020.1746265DOI Listing

BILATERAL SEROUS RETINAL DETACHMENT AND UVEITIS ASSOCIATED WITH PEMBROLIZUMAB TREATMENT IN METASTATIC MELANOMA.

Retin Cases Brief Rep 2020 Apr 1. Epub 2020 Apr 1.

Department of Ophthalmology, Amsterdam University Medical Center, Amsterdam, the Netherlands.

Purpose: To describe the pathological features, treatment, and resolution of pembrolizumab-associated retinal detachment.

Methods: A case report with a brief review of the literature and details of patient presentation, physical examination, systemic workup, fluorescein angiography, and indocyanine angiography.

Results: A 25-year-old white woman was diagnosed with unresectable metastatic melanoma of the skin with a BRAF V600E mutation. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000999DOI Listing

The JAM-B/c-src/MMP9 pathway is associated with progression and regulates the invasion of pancreatic cancer.

J Cancer 2020 5;11(11):3246-3255. Epub 2020 Mar 5.

Department of General Surgery, Second Affiliated Hospital, Xi'an Jiaotong University, 157 West 5 th Road, Xi'an, 710004, China.

Junctional adhesion molecule B (JAM-B) is a multifunctional transmembrane protein that plays an important role in tumor progression. JAM-B is significantly upregulated in gastric cancer, melanoma cell metastasis and oral squamous cell carcinoma. JAM-2 may also function as a putative tumor suppressor in the progression and metastasis of colorectal cancer. Read More

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http://dx.doi.org/10.7150/jca.40953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097935PMC

Sitagliptin affects gastric cancer cells proliferation by suppressing Melanoma-associated antigen-A3 expression through Yes-associated protein inactivation.

Cancer Med 2020 Mar 30. Epub 2020 Mar 30.

Department of Geriatrics, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

Sitagliptin is an emerging oral hypoglycemic agent that inhibits the development of a wide variety of tumors. Current researches indicate that the abnormal activation of Yes-associated protein (YAP) promotes the proliferation and poor prognosis of multiple tumors. However, the ability of sitagliptin to regulate YAP and its effects on gastric cancer (GC) cells remain unclear. Read More

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http://dx.doi.org/10.1002/cam4.3024DOI Listing

The First Application of Nanoelectrochemotherapy in Feline Oral Malignant Melanoma Treatment-Case Study.

Animals (Basel) 2020 Mar 26;10(4). Epub 2020 Mar 26.

Department of Molecular and Cellular Biology, Wroclaw Medical University, Wroclaw 50-556, Poland.

Background: The aim of this study was to present the first domestic animal trial of nanosecond electroporation with chemotherapy and CO laser surgery.

Methods: sixteen-year-old domestic cat with diagnosed melanoma on oral cavity was the case used in the study. Firstly, CO laser surgery was used for the removal of most of tumor mass. Read More

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http://dx.doi.org/10.3390/ani10040556DOI Listing

Potential association between oral mucosal nevus and melanoma: A preliminary clinicopathologic study.

Oral Dis 2020 Mar 28. Epub 2020 Mar 28.

Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objectives: To assess potential association between oral nevi (ON) and nevus-associated melanoma (NAM), in which melanoma cells coexist with nevus cells.

Methods: A total of 74 ON patients and 7 NAM patients were retrospectively reviewed. Comparative and regression analyses of clinical and histological data were performed between two groups. Read More

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http://dx.doi.org/10.1111/odi.13335DOI Listing

Multifunctional Immunoliposomes Combining Catalase and PD-L1 Antibodies Overcome Tumor Hypoxia and Enhance Immunotherapeutic Effects Against Melanoma.

Int J Nanomedicine 2020 10;15:1677-1691. Epub 2020 Mar 10.

Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Peking University, Beijing, People's Republic of China.

Background: Immune checkpoint blockades (ICBs) are a promising treatment for cancers such as melanoma by blocking important inhibitory pathways that enable tumor cells to evade immune attack. Programmed death ligand 1 monoclonal antibodies (aPDL1s) can be used as an ICB to significantly enhance the effectiveness of tumor immunotherapy by blocking the PD-1/PD-L1 inhibitory pathway. However, the effectiveness of aPDL1s may be limited by low selectivity in vivo and immunosuppressed tumor microenvironment including hypoxia. Read More

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http://dx.doi.org/10.2147/IJN.S225807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082626PMC

PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice.

PLoS One 2020 26;15(3):e0228339. Epub 2020 Mar 26.

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China.

The increased PD-L1 expression induces poorer prognosis in melanoma. The small molecule inhibitors of PD-1/PD-L1 pathways have been an encouraging drug development strategy because of good affinity and oral bioavailability without immunogenicity and immunotoxicities of PD-1/PD-L1 antibodies. In this study, we studied the effects of PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, on PD-1/PD-L1 binding and the cytokines secretion in human CD3+ cells in vitro. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228339PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098565PMC

Long-term survival after surgical treatment followed by adjuvant systemic therapy for primary duodenal melanoma.

Clin J Gastroenterol 2020 Mar 20. Epub 2020 Mar 20.

DASA-Diagnósticos da América SA/Laboratório Salomão Zoppi, Av. Juruá, 434. Alphaville, Barueri, SP, 06455-010, Brazil.

Primary mucosal malignant melanomas of the gastrointestinal tract are rare tumors associated to poor prognosis. Primary duodenal involvement by pigmented lesions is even more uncommon, and only a few reports exist in the literature. We report the case of a patient with large primary duodenal melanoma that presented with upper intestinal obstruction and bleeding that was submitted to urgent pancreaticoduodenectomy followed by adjuvant systemic therapy with an oral alkylating agent (temozolomide) plus intravenous cisplatin. Read More

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http://dx.doi.org/10.1007/s12328-020-01112-9DOI Listing

The suppressive effect of dabrafenib, a therapeutic agent for metastatic melanoma, in IgE-mediated allergic inflammation.

Int Immunopharmacol 2020 Mar 17;83:106398. Epub 2020 Mar 17.

Cell & Matrix Research Institute, Department of Pharmacology, Kyungpook National University School of Medicine, Daegu, Republic of Korea. Electronic address:

The functional inhibition of mast cells, which serve as a key effector cells in allergic reactions may be a specific target for treating immunoglobulin (Ig)E-mediated allergic reactions, which occur in various allergic diseases including anaphylaxis, asthma, and atopic dermatitis. In this study, we demonstrated the effects of dabrafenib, a therapeutic agent used to treat metastatic melanoma, with a focus on mast cell activation and local cutaneous anaphylaxis. In two types of mast cells (RBL-2H3 and mouse bone marrow-derived mast cells), dabrafenib (0. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106398DOI Listing
March 2020
2.472 Impact Factor