4,459 results match your criteria Oral Malignant Melanoma


Ipilimumab and Nivolumab-Induced Colitis in a Patient With Recurrent Metastatic Melanoma.

Cureus 2021 Apr 11;13(4):e14414. Epub 2021 Apr 11.

Gastroenterology, Wayne State University, Detroit, USA.

Ipilimumab and nivolumab are immune checkpoint inhibitors that have recently been used in the treatment of metastatic melanoma and other cancers. Immune-mediated colitis is one of their adverse events that need to be differentiated from low-grade diarrhea as one of the most common side effects. A 51-year-old woman with relapsed metastatic melanoma presented with intractable diarrhea, nausea, vomiting, and generalized abdominal pain. Read More

View Article and Full-Text PDF

Phase I study of ceralasertib (AZD6738), a novel DNA damage repair agent, in combination with weekly paclitaxel in refractory cancer.

Clin Cancer Res 2021 May 11. Epub 2021 May 11.

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Samsung Medical Center, Sungkyunkwan University School of Medicine

Purpose: Ceralasertib is a potent and selective oral inhibitor of the serine/threonine protein kinase ataxia telangiectasia and Rad3-related (ATR) protein.

Experimental Design: Eligible patients with solid tumors, enriched for melanoma, received ceralasertib in combination with a fixed dose of paclitaxel (80 mg/m on D1, D8, D15) in 28-day cycles. The dose of ceralasertib was escalated to reach a maximum tolerated dose (MTD) in a rolling 6 design. Read More

View Article and Full-Text PDF

Uncommon Pigmented Carcinoma In Situ: Case Report and Brief Review.

Clin Pathol 2021 Jan-Dec;14:2632010X211009819. Epub 2021 Apr 20.

Department of Pathology, School of Medicine, State University of Campinas (UNICAMP), Campinas, Brazil.

Pigmented lesions of the oral mucosa encompass several benign and malignant conditions that may be a matter of concern under both clinical and histopathological views. We reported a case of a 62-year-old woman, presenting with an asymptomatic, deeply pigmented lesion on the soft palate. On examination, it appeared asymmetrical, with irregular borders and an area of ulceration. Read More

View Article and Full-Text PDF

Fungal Melanonychia as a Solitary Black Linear Vertical Nail Plate Streak: Case Report and Literature Review of Candida-Associated Longitudinal Melanonychia Striata.

Cureus 2021 Apr 1;13(4):e14248. Epub 2021 Apr 1.

Pain Management/Palliative Care, Scripps Memorial Hospital, La Jolla, USA.

Longitudinal melanonychia striata, presenting as a black linear vertical band of the nail plate, can be caused by pigmented lesions and non-pigmented etiologies. A fungal infection of the nail plate, also referred to as onychomycosis or tinea unguim, can result from dermatophytes, non-dermatophyte molds, and . Albeit rare, -associated fungal melanonychia can present as a longitudinal black nail plate streak. Read More

View Article and Full-Text PDF

Preclinical development and first in human study of KA2507, a selective and potent inhibitor of histone deacetylase 6, for patients with refractory solid tumors.

Clin Cancer Res 2021 May 4. Epub 2021 May 4.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center.

Purpose: Inhibition of histone deacetylase 6 (HDAC6) is predicted to deliver both direct antitumor activity and modulation of the antitumor immune response. This study describes the development of a novel HDAC6 inhibitor.

Patients And Methods: KA2507 was characterized in HDAC biochemical and cellular target engagement assays and in preclinical efficacy models of melanoma and colorectal cancer. Read More

View Article and Full-Text PDF

An orally available PD-1/PD-L1 blocking peptide OPBP-1-loaded trimethyl chitosan hydrogel for cancer immunotherapy.

J Control Release 2021 May 1;334:376-388. Epub 2021 May 1.

School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

Blockade of the immune checkpoint PD-1/PD-L1 with monoclonal antibodies demonstrated unprecedented clinical efficacies in many cancers. But the orally available low molecular weight inhibitors remain infancy. Compared to small molecules, peptide exhibits better selectivity and fewer side effects, but poor half-life and a big challenge to be orally administrated. Read More

View Article and Full-Text PDF

Case Report: Blurred Vision and Eruptive Nevi - Bilateral Diffuse Uveal Melanocytic Proliferation With Mucocutaneous Involvement in a Lung Cancer Patient.

Front Oncol 2021 13;11:658407. Epub 2021 Apr 13.

Eye Center, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

We describe a case of a 65-year old patient presenting with unusual mucocutaneous melanocytic proliferations of a Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP) imitating a multifocal melanoma in situ, which improved dramatically after plasmapheresis. The patient first presented at the dermatology department due to rapidly evolving brown and black macules on the glans penis. Further skin involvement of the perineal and perianal region, mamillae and oral mucosa was stated. Read More

View Article and Full-Text PDF

FGFR2 Extracellular Domain In-Frame Deletions are Therapeutically Targetable Genomic Alterations that Function as Oncogenic Drivers in Cholangiocarcinoma.

Cancer Discov 2021 Apr 29. Epub 2021 Apr 29.

Department of Medical Oncology, Dana-Farber Cancer Institute.

We conducted next generation DNA sequencing on 335 biliary tract cancers and characterized the genomic landscape by anatomic site within the biliary tree. In addition to frequent FGFR2 fusions among patients with intrahepatic cholangiocarcinoma (IHCC), we identified FGFR2 extracellular domain in-frame deletions (EIDs) in 5 of 178 (2.8%) patients with IHCC, including two patients with FGFR2 p. Read More

View Article and Full-Text PDF

Identification of 15 lncRNAs Signature for Predicting Survival Benefit of Advanced Melanoma Patients Treated with Anti-PD-1 Monotherapy.

Cells 2021 Apr 22;10(5). Epub 2021 Apr 22.

Department of Radiation Oncology, Universitätsklinikum Erlangen, 91054 Erlangen, Germany.

The blockade of programmed cell death protein 1 (PD-1) as monotherapy has been widely used in melanoma, but to identify melanoma patients with survival benefit from anti-PD-1 monotherapy is still a big challenge. There is an urgent need for prognostic signatures improving the prediction of immunotherapy responses of these patients. We analyzed transcriptomic data of pre-treatment tumor biopsies and clinical profiles in advanced melanoma patients receiving only anti-PD-1 monotherapy (nivolumab or pembrolizumab) from the PRJNA356761 and PRJEB23709 data sets as the training and validation cohort, respectively. Read More

View Article and Full-Text PDF

Cystatin M/E (Cystatin 6): A Janus-Faced Cysteine Protease Inhibitor with Both Tumor-Suppressing and Tumor-Promoting Functions.

Cancers (Basel) 2021 Apr 14;13(8). Epub 2021 Apr 14.

Faculté de Médecine, Université de Tours, 37000 Tours, France.

Alongside its contribution in maintaining skin homeostasis and its probable involvement in fetal and placental development, cystatin M/E (also known as cystatin 6) was first described as a tumor suppressor of breast cancer. This review aims to provide an update on cystatin M/E with particular attention paid to its role during tumorigenesis. Cystatin M/E, which is related to type 2 cystatins, displays the unique property of being a dual tight-binding inhibitor of both legumain (also known as asparagine endopeptidase) and cysteine cathepsins L, V and B, while its expression level is epigenetically regulated via the methylation of the promoter region. Read More

View Article and Full-Text PDF

Metabolism and Interspecies Variation of IMMH-010, a Programmed Cell Death Ligand 1 Inhibitor Prodrug.

Pharmaceutics 2021 Apr 21;13(5). Epub 2021 Apr 21.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China.

IMMH-010 is an ester prodrug of YPD-29B, a potent programmed cell death ligand 1 (PD-L1) inhibitor. The metabolism of IMMH-010 was investigated and compared in various species. Four metabolites of IMMH-010 were identified, and the major metabolite was the parent compound, YPD-29B, which was mainly catalyzed by carboxylesterase 1 (CES1). Read More

View Article and Full-Text PDF

Primary malignant mucosal melanoma of the maxillofacial area.

J Korean Assoc Oral Maxillofac Surg 2021 Apr;47(2):76-81

Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry, Seoul, Korea.

Objectives: We aimed to collect and report data from all patients who have been diagnosed with mucosal malignant melanoma to obtain the epidemiology and principles of current treatments.

Materials And Methods: Between January 2008 and December 2018, 20 patients underwent surgery or follow-up observations at Yonsei University Dental Hospital. The patients' clinical information was reviewed retrospectively. Read More

View Article and Full-Text PDF

Correlation Between KIT Expression and Mutations in 2 Subtypes of Canine Oral Melanocytic Neoplasms.

Vet Pathol 2021 Apr 29:3009858211009784. Epub 2021 Apr 29.

3078Michigan State University, Lansing, MI, USA.

mutations have been reported in 15% to 40% of certain human melanoma subtypes, including those histologically similar to canine oral malignant melanomas. Therapeutic response to tyrosine kinase inhibitors has been demonstrated in those human patients. As canine oral malignant melanomas tend to have a poor prognosis despite aggressive surgical removal, evaluation of KIT expression and identification of mutations in canine oral melanocytic neoplasms was performed to determine if there is any indication that tyrosine kinase inhibitor drugs might effectively treat any of these cases. Read More

View Article and Full-Text PDF

Refractory dermatitis contributed by pityriasis versicolor: a case report.

J Med Case Rep 2021 Apr 23;15(1):212. Epub 2021 Apr 23.

Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Lincoln Tower 1300, 1800 Cannon Dr, Columbus, Ohio, 43210, USA.

Background: Dermatologic toxicity is a very common immune-related adverse event (irAE) for patients with melanoma who are receiving immune checkpoint inhibitor therapy (ICI). Concurrent skin infection, such as in the case of pityriasis versicolor reported here, can mimic and/or exacerbate dermatologic toxicity from irAE.

Case Presentation: A 58-year-old Caucasian man with a history of pityriasis versicolor infection and metastatic melanoma received ICI therapy. Read More

View Article and Full-Text PDF

Exogenous sex hormones, menstrual and reproductive history, and risk of non-melanoma skin cancer among women: a systematic literature review and meta-analysis.

Sci Rep 2021 Apr 19;11(1):8524. Epub 2021 Apr 19.

Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.

Non-melanoma skin cancers (NMSC) are more frequent among men, but women (especially those aged < 40 years) have experienced steeper growth in their incidence rates in recent years. Hormonal factors were hypothesized to be playing a role in modulating NMSC risk, but the studies published to date provided conflicting results. We systematically reviewed and meta-analysed the studies focusing on the association between hormone-related characteristics (use of exogenous sex hormones, and aspects of menstrual and reproductive history) and the risk of NMSC among women. Read More

View Article and Full-Text PDF

Squamous cell carcinoma of the tongue with cardiac metastasis on 18F-FDG PET/CT: A case report and literature review.

Medicine (Baltimore) 2021 Apr;100(15):e25529

Department of Nuclear Medicine, Centre Hospitalier Universitaire Bichat.

Introduction: The most common malignancies metastasizing to the heart are cancers of the lung, breast, mesothelioma, melanoma, leukemia, and lymphoma. Cardiac metastasis from a tongue cancer is a rare finding and only a few cases have been reported previously in the literature. In this case report and literature review, we discuss the main clinical features of patients with cardiac metastases secondary to a tongue cancer and imaging modalities performed, especially the 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). Read More

View Article and Full-Text PDF

A novel DPP10 (intergenic)-NTRK3 fusion in a patient with facial malignant melanoma and potentially benefit from NTRK inhibitors.

Oral Oncol 2021 Apr 9:105288. Epub 2021 Apr 9.

Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 210000, China. Electronic address:

View Article and Full-Text PDF

Teratogenic effect of isotretinoin in both fertile females and males (Review).

Exp Ther Med 2021 May 23;21(5):534. Epub 2021 Mar 23.

Department of Dermatology, 'Elias' Emergency University Hospital, 011461 Bucharest, Romania.

Isotretinoin is an oral derivate of vitamin A that has been used since 1982 for the treatment of multiple dermatologic conditions such as severe acne, rosacea, scarring alopecia, ichthyosis or non-melanoma skin cancer prophylaxis. The recommended dose is 0.5-1 mg/kg/day for a period of 4-6 months in sebaceous gland pathologies. Read More

View Article and Full-Text PDF

Atypical anti-glomerular basement membrane glomerulonephritis in a patient with metastatic melanoma treated with mitogen-activated protein kinase and immune checkpoint inhibitors: a case report.

J Med Case Rep 2021 Apr 3;15(1):186. Epub 2021 Apr 3.

Division of Nephrology, University of Massachusetts Medical School -Baystate, Springfield, MA, USA.

Background: Immune checkpoint inhibitors and mitogen-activated protein kinase inhibitors have become the standard of care in patients with advanced melanoma bearing V600 mutations. However, little is known about their nephrotoxicity. To date, only two cases of anti-glomerular basement membrane glomerulonephritis after exposure to checkpoint inhibitors have been documented. Read More

View Article and Full-Text PDF

Oral Manifestations in Melanoma Patients Treated with Target or Immunomodulatory Therapies.

J Clin Med 2021 Mar 19;10(6). Epub 2021 Mar 19.

Department of Medical Sciences, Dermatologic Clinic, University of Turin, 10126 Turin, Italy.

Background: BRAF (v-raf murine sarcoma viral oncogene homolog B1) and MEK (mitogen activated protein kinase) inhibitors, as well as immunotherapy against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and the programmed cell death 1 (PD-1) receptor and its ligand (PD-L1), have shown good results in improving the disease-free survival of patients with metastatic melanoma (MM). The aim of this review is to summarize the main oral adverse events (oAEs) occurring in patients undergoing target or immunotherapy. We proposed two separate sections: oAEs during the treatment with (1) target therapies with BRAF and MEK inhibitors and tyrosine kinase inhibitors (gingival hyperplasia, pigmentation disorders, squamo-proliferative lesions) and (2) immunotherapies with CTLA-4 or PD1 inhibitors (lichenoid reactions, immuno-bullous reactions, xerostomia and other reactions). Read More

View Article and Full-Text PDF

Mucosal Melanoma of the Hard Palate: Surgical Treatment and Reconstruction.

Int J Environ Res Public Health 2021 03 24;18(7). Epub 2021 Mar 24.

School of Medicine, Vita-Salute San Raffaele University, 20100 Milano, Italy.

Mucosal melanomas of the head and neck region are uncommon pathologies that can affect the oral cavity, and are characterized by a high rate of mortality. Considering the lack of knowledge regarding risk and prognostic factors, current best clinical practice is represented by a large surgical excision with disease-free margins, eventually associated with a reconstructive flap. Indeed, given the frequent necessity of postoperative radiotherapy and fast healing process, a reconstruction of the surgical gap is advisable. Read More

View Article and Full-Text PDF

Prognostic and Clinicopathological Significance of /Cyclin D1 Upregulation in Melanomas: A Systematic Review and Comprehensive Meta-Analysis.

Cancers (Basel) 2021 Mar 15;13(6). Epub 2021 Mar 15.

School of Dentistry, University of Granada, 18010 Granada, Spain.

Our objective was to evaluate the prognostic and clinicopathological significance of cyclin D1 (CD1) overexpression/CCND1 amplification in melanomas. We searched studies published before September 2019 (PubMed, Embase, Web of Science, Scopus). We evaluated the quality of the studies included (QUIPS tool). Read More

View Article and Full-Text PDF

Characterization of Primary Cultures of Normal and Neoplastic Canine Melanocytes.

Animals (Basel) 2021 Mar 10;11(3). Epub 2021 Mar 10.

Department of Veterinary Medicine, University of Perugia, 06126 Perugia, Italy.

Although numerous animal models, especially mouse models, have been established for the study of melanoma, they often fail to accurately describe the mechanisms of human disease because of their anatomic, physiological, and immune differences. The dog, as a spontaneous model of melanoma, is nowadays considered one of the most valid alternatives due to the heterogeneity of clinical presentations and of histological and genetic similarities of canine melanoma with the human counterpart. The aim of the study was to optimize a protocol for the isolation and cultivation of healthy and neoplastic canine melanocytes derived from the same animal and obtained from cutaneous and mucosal (oral) sites. Read More

View Article and Full-Text PDF

CDK4 and TERT amplification in head and neck mucosal melanoma.

J Oral Pathol Med 2021 Apr 2. Epub 2021 Apr 2.

Department of Stomatology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: Recent high-throughput sequencing studies have revealed frequent CDK4 and TERT amplification in mucosal melanoma, suggesting that they are potential therapeutic targets. In this study, we investigated the statuses of CDK4 and TERT in head and neck mucosal melanoma (HNMM) with the aim of providing preclinical data to support future clinical trials.

Methods: In total, 29 HNMM samples were collected, including 16 oral mucosal melanoma (OMM) samples and 13 nasal cavity/sinuses melanoma (SNMM) samples. Read More

View Article and Full-Text PDF

Immunotherapy-Resistant Vitreoretinal Metastatic Melanoma.

Ocul Oncol Pathol 2021 Mar 3;7(1):62-65. Epub 2020 Nov 3.

Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Purpose: To describe 2 cases of vitreoretinal metastases in patients treated with immunotherapy for metastatic melanoma.

Methods: Retrospective case series.

Results: We pre-sent 2 patients with metastatic melanoma treated with systemic immunotherapy with subsequent development of ocular vitreoretinal metastasis. Read More

View Article and Full-Text PDF

Prognostic value and therapeutic implications of nodal involvement in head and neck mucosal melanoma.

Head Neck 2021 Mar 30. Epub 2021 Mar 30.

Department of Head & Neck Surgery, Gustave Roussy Cancer Campus, Villejuif, France.

Background: The prognostic significance of nodal involvement is not well established in head and neck mucosal melanoma (HNMM).

Methods: A retrospective, monocentric study was performed on 96 patients with HNMM treated between 2000 and 2017.

Results: At diagnosis, seventeen patients (17. Read More

View Article and Full-Text PDF

Recurrent Episodes with Serous Retinal Detachment and Anterior Uveitis in a Patient Using Nivolumab (Anti -PD-1 Antibody) Therapy: A case report and literature review.

Semin Ophthalmol 2021 Mar 29:1-6. Epub 2021 Mar 29.

Department of Medical Oncology, Acıbadem Mehmet Ali Aydinlar University, Istanbul, Turkey.

Nivolumab is an immune checkpoint inhibitor that has recently been widely used for metastatic malignant melanoma. We report a case who developed multiple different ocular immune-related side effects (iRAEs) related to nivolumab. A 60-year-old man on nivolumab treatment for metastatic malignant melanoma developed a decrease in vision in both eyes several days after the third infusion. Read More

View Article and Full-Text PDF

Apigenin-Loaded PLGA-DMSA Nanoparticles: A Novel Strategy to Treat Melanoma Lung Metastasis.

Mol Pharm 2021 05 29;18(5):1920-1938. Epub 2021 Mar 29.

Department of Polymer Science and Technology, University College of Science and Technology, University of Calcutta, Kolkata 700009, India.

The flavone apigenin (APG), alone as well as in combination with other chemotherapeutic agents, is known to exhibit potential anticancer effects in various tumors and inhibit growth and metastasis of melanoma. However, the potential of apigenin nanoparticles (APG-NPs) to prevent lung colonization of malignant melanoma has not been well investigated. APG-loaded PLGA-NPs were surface-functionalized with -2,3-dimercaptosuccinic acid (DMSA) for the treatment of melanoma lung metastasis. Read More

View Article and Full-Text PDF

Editorial: HPV and Host Interaction.

Front Cell Infect Microbiol 2021 11;11:638005. Epub 2021 Mar 11.

Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France.

View Article and Full-Text PDF

Nonendodontic periapical lesions: a retrospective descriptive study in a Brazilian population.

Med Oral Patol Oral Cir Bucal 2021 03 27. Epub 2021 Mar 27.

Post graduation Program in Dentistry, Estácio de Sá University Av. Alfredo Baltazar da Silveira, 580 cobertura CEP 22790-701, Recreio dos Bandeirantes, Rio de Janeiro/RJ, Brazil

Background: Several nonendodontic diseases can occur in the periapical region, resembling endodontic inflammatory conditions. Therefore, the aim of the present study was to determine the frequency of nonendodontic periapical lesions diagnosed in a Brazilian population.

Material And Methods: The files of two Oral Pathology laboratories were reviewed and all cases including at least one clinical diagnosis of endodontic periapical lesions were selected for the study. Read More

View Article and Full-Text PDF