3,894 results match your criteria Oral Malignant Melanoma


Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms.

Sci Rep 2019 Apr 18;9(1):6272. Epub 2019 Apr 18.

Division of Cancer-Hull York Medical School, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.

The bidirectional association between coagulation and cancer has been established. However, anticoagulant therapies have been reported to have beneficial outcomes by influencing the vascularisation of the tumours. In this study the influence of a set of anticoagulants on tumour formation, invasion and vascularisation was examined. Read More

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http://dx.doi.org/10.1038/s41598-019-42738-1DOI Listing

Oral Melanomas: A Case Series of a Deadly Neoplasm.

J Oral Maxillofac Surg 2019 Mar 26. Epub 2019 Mar 26.

Oral and Maxillofacial Surgery Attending, University of Florida College of Dentistry, Gainesville, FL.

Purpose: To describe and discuss the demographic and clinical features of oral melanomas, which are relatively rare but deadly neoplasms, and list the criteria for their diagnosis to increase early detection.

Materials And Methods: An institutional review board-approved retrospective search of oral melanomas was performed in the archives of the University of Florida Oral and Maxillofacial Pathology Biopsy Service (Gainesville, FL) from 2015 through 2018. Exclusion criteria included cases with inconclusive diagnosis, skin involvement, and missing clinical data or slide material. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02782391193034
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http://dx.doi.org/10.1016/j.joms.2019.03.018DOI Listing
March 2019
1 Read

Sicca Syndrome Associated with Immune Checkpoint Inhibitor Therapy.

Oncologist 2019 Apr 17. Epub 2019 Apr 17.

Sjögren's Syndrome and Salivary Gland Dysfunction Unit, National Institutes of Health, Baltimore, Maryland, USA.

Background: The objective of this study was to characterize the clinicopathologic features of sicca syndrome associated with immune checkpoint inhibitor (ICI) therapy.

Subjects, Materials, And Methods: Consecutive patients with new or worsening xerostomia in the setting of ICI treatment for benign or malignant neoplastic disease were evaluated, including labial salivary gland biopsy (LSGB).

Results: Twenty patients (14 male; median age 57 years) had metastatic melanoma ( = 10), metastatic carcinoma ( = 6), or recurrent respiratory papillomatosis ( = 4) and were being treated with avelumab ( = 8), nivolumab ( = 5), pembrolizumab ( = 4), nivolumab/ipilimumab ( = 2), and M7824, a biologic targeting programmed cell death ligand 1 (PD-L1) and transforming growth factor ß ( = 1). Read More

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http://theoncologist.alphamedpress.org/lookup/doi/10.1634/th
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http://dx.doi.org/10.1634/theoncologist.2018-0823DOI Listing
April 2019
3 Reads

Estimation of exposure durations for vitamin D production and sunburn risk in Switzerland.

J Expo Sci Environ Epidemiol 2019 Apr 16. Epub 2019 Apr 16.

Institute for Work and Health, University of Lausanne and Geneva, 1010 Epalignes- Lausanne, Lausanne, Switzerland.

Although overexposure to solar ultraviolet radiation (UVR) is responsible for cutaneous melanoma and epithelial skin cancer and can cause negative health effects such as sunburn, a "little and often" exposure regime is often suggested to produce naturally recommended vitamin D levels, being essential for skeletal health. This study aimed to quantify solar UV doses needed to trigger 1000 International Units (IU) vitamin D doses and, at the same time, producing sunburn in Switzerland. Solar UV erythema irradiance (in mW/m) measured at four meteorological stations in Switzerland for the period 2005-2017 were used to evaluate effective solar UV radiation producing 1000 IU vitamin D doses in skin phototype II and III individuals. Read More

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http://www.nature.com/articles/s41370-019-0137-2
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http://dx.doi.org/10.1038/s41370-019-0137-2DOI Listing
April 2019
1 Read

Curcumin: a potent agent to reverse epithelial-to-mesenchymal transition.

Cell Oncol (Dordr) 2019 Apr 13. Epub 2019 Apr 13.

Department of Medical Biotechnology Research Center, School of Medicine, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, P.O. Box: 91779-48564, Mashhad, Iran.

Background: Epithelial-to-mesenchymal transition (EMT) is involved in tumor progression, invasion, migration and metastasis. EMT is a process by which polarized epithelial cells acquire motile mesothelial phenotypic features. This process is initiated by disassembly of cell-cell contacts through the loss of epithelial markers and replacement of these markers by mesenchymal markers. Read More

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http://dx.doi.org/10.1007/s13402-019-00442-2DOI Listing
April 2019
1 Read

Plant Virus-Like Particle In Situ Vaccine for Intracranial Glioma Immunotherapy.

Cancers (Basel) 2019 Apr 10;11(4). Epub 2019 Apr 10.

Department of NanoEngineering, University of California San Diego, La Jolla, CA 92093, USA.

Despite aggressive multi-modality treatment with surgery, radiation and chemotherapies, malignant glioma inevitably recurs and has dismal survival rates. Recent progress in immunotherapy has led to a resurgence of interest, and immunotherapies are being investigated for treatment of glioma. However, the unique brain anatomy and a highly immunosuppressive glioma microenvironment pose significant challenges to achieving efficacy. Read More

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http://dx.doi.org/10.3390/cancers11040515DOI Listing
April 2019
1 Read

Safety and efficacy of tofacitinib for up to 9.5 years in the treatment of rheumatoid arthritis: final results of a global, open-label, long-term extension study.

Arthritis Res Ther 2019 Apr 5;21(1):89. Epub 2019 Apr 5.

Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX, USA.

Background: Final data are presented for the ORAL Sequel long-term extension (LTE) study evaluating the safety and efficacy of tofacitinib 5 mg and 10 mg twice daily (BID) for up to 9.5 years in patients with rheumatoid arthritis (RA).

Methods: Eligible patients had previously completed a phase 1, 2, or 3 qualifying index study of tofacitinib and received open-label tofacitinib 5 mg or 10 mg BID. Read More

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http://dx.doi.org/10.1186/s13075-019-1866-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451219PMC

Antitumor and Apoptosis-inducing Effects of Piperine on Human Melanoma Cells.

Anticancer Res 2019 Apr;39(4):1883-1892

Department of Companion and Laboratory Animal Science, Kongju National University, Yesan, Republic of Korea

Background/aim: Piperine is a major pungent alkaloid present in black pepper (Piper nigrum L). This study investigated the potential anticancer effects of piperine on human melanoma cells and explored the potential pharmacological mechanisms in vitro and in vivo.

Materials And Methods: Studies were performed using the MTT assay, 4',6-diamidino-2-phenylindole (DAPI) staining, western blotting, a xenograft model, the terminal deoxynucleotidyl transferase dUTP nick end labeling assay, and immunohistochemistry. Read More

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http://dx.doi.org/10.21873/anticanres.13296DOI Listing
April 2019
2 Reads

Treatment of the facial basal cell carcinoma with the use of photodynamic therapy: A case report.

Dent Med Probl 2019 Jan-Mar;56(1):105-110

Department of Oral Surgery, Faculty of Dentistry, Wrocław Medical University, Poland.

Basal cell carcinoma (BCC) is the most common skin cancer. It accounts for approx. 80% of human skin cancers and belongs to the group of non-melanoma skin cancers (NMSC). Read More

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http://dx.doi.org/10.17219/dmp/100507DOI Listing
April 2019
1 Read

Incidence of complications in dermatological surgery of melanoma and non-melanoma skin cancer in patients with multiple comorbidity and/or antiplatelet-anticoagulants. Five year experience in our Hospital.

Cir Cir 2019 ;86(1):15-23

Dermatology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico City. Mexico.

Introduction: Surgery is performed more frequently now at days, due to the increasing incidence of melanoma and no-melanoma skin cancer. There are different opinions among dermatologic surgeons between to continue or discontinue antithrombotic therapy prior to the procedure, which increases the risk of thromboembolic events. Prophylaxis with oral antibiotics in the postsurgical period is controversial. Read More

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http://dx.doi.org/10.24875/CIRUE.M18000003DOI Listing
January 2019
1 Read

Histologic evaluation of mandibular and medial retropharyngeal lymph nodes during staging of oral malignant melanoma and squamous cell carcinoma in dogs.

J Am Vet Med Assoc 2019 Apr;254(8):938-943

Objective: To assess histologic evaluation of mandibular lymph nodes (MLNs) and medial retropharyngeal lymph nodes (MRLNs) for metastatic disease during tumor staging for dogs with oral malignant melanoma (OMM) and oral squamous cell carcinoma (OSCC).

Design: Retrospective multi-institutional study.

Animals: 27 dogs with OMM and 21 dogs with OSCC. Read More

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http://dx.doi.org/10.2460/javma.254.8.938DOI Listing

MAGE-A expression in oral and laryngeal leukoplakia predicts malignant transformation.

Mod Pathol 2019 Apr 1. Epub 2019 Apr 1.

Department of Oral and Maxillofacial Surgery, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Leukoplakia is a potential precursor of oral as well as laryngeal squamous cell carcinoma. Risk assessment of malignant transformation based on the grade of dysplasia of leukoplakia often does not lead to reliable results. However, oral squamous cell carcinoma, laryngeal squamous cell carcinoma, and leukoplakia express single or multiple members of the melanoma-associated antigens A (MAGE-A) family, while MAGE-A are absent in healthy mucosal tissue. Read More

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http://dx.doi.org/10.1038/s41379-019-0253-5DOI Listing
April 2019
3 Reads

Severe Epididymo-Orchitis and Encephalitis Complicating Anti-PD-1 Therapy.

Oncologist 2019 Apr 1. Epub 2019 Apr 1.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Background: Immune checkpoint inhibitors such as pembrolizumab and nivolumab have emerged as active treatment options for patients with many cancers, including metastatic melanoma, but can also cause symptomatic or life-threatening immune-related adverse events, including encephalitis. Epididymitis and orchitis are rare complications of these therapies.

Case Presentation: We describe herein a patient with metastatic melanoma who developed epididymo-orchitis followed by encephalitis while receiving pembrolizumab. Read More

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http://theoncologist.alphamedpress.org/lookup/doi/10.1634/th
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http://dx.doi.org/10.1634/theoncologist.2018-0722DOI Listing
April 2019
7 Reads

Neurocognitive Function and Quality of Life Outcomes in the ONTRAC Study for Skin Cancer Chemoprevention by Nicotinamide.

Geriatrics (Basel) 2019 Mar 25;4(1). Epub 2019 Mar 25.

Dermatology and Bosch Institute, University of Sydney at Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia.

Nicotinamide (vitamin B3) has photoprotective effects and reduces skin cancer incidence in high risk patients. Nicotinamide also improves cognition in animal models. As part of the ONTRAC (Oral Nicotinamide To Reduce Actinic Cancer) phase III placebo-controlled, randomized trial to assess nicotinamide's efficacy in skin cancer prevention, we included clinical neurocognitive function and patient-reported quality of life assessments at baseline and after 12 months of intervention in individuals with previous skin cancer in order to assess any effect of oral nicotinamide (500 mg po twice daily) on cognitive function and quality of life. Read More

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http://dx.doi.org/10.3390/geriatrics4010031DOI Listing
March 2019
2 Reads

Patient-reported outcomes in patients with resected, high-risk melanoma with BRAF or BRAF mutations treated with adjuvant dabrafenib plus trametinib (COMBI-AD): a randomised, placebo-controlled, phase 3 trial.

Lancet Oncol 2019 Mar 27. Epub 2019 Mar 27.

Melanoma Institute Australia, Sydney, NSW, Australia; The University of Sydney, Sydney, NSW, Australia; Royal North Shore Hospital, Sydney, NSW, Australia; Mater Hospital, Sydney, NSW, Australia.

Background: In the phase 3 COMBI-AD study, patients with resected, stage III melanoma with BRAF or BRAF mutations received adjuvant dabrafenib plus trametinib or placebo. The primary analysis showed that dabrafenib plus trametinib significantly improved relapse-free survival at 3 years. These results led to US Food and Drug Administration approval of dabrafenib plus trametinib as adjuvant treatment for patients with resected stage III melanoma with BRAF or BRAF mutations. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30940-9DOI Listing
March 2019
4 Reads

Increased cancer risk in patients undergoing dialysis: a population-based cohort study in North-Eastern Italy.

BMC Nephrol 2019 Mar 28;20(1):107. Epub 2019 Mar 28.

Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini 2, 33081, Aviano, (PN), Italy.

Background: In southern Europe, the risk of cancer in patients with end-stage kidney disease receiving dialysis has not been well quantified. The aim of this study was to assess the overall pattern of risk for de novo malignancies (DNMs) among dialysis patients in the Friuli Venezia Giulia region, north-eastern Italy.

Methods: A population-based cohort study among 3407 dialysis patients was conducted through a record linkage between local healthcare databases and the cancer registry (1998-2013). Read More

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http://dx.doi.org/10.1186/s12882-019-1283-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437907PMC
March 2019
1 Read

Expression of mitochondrial dynamics markers during melanoma progression: Comparative study of head and neck cutaneous and mucosal melanomas.

J Oral Pathol Med 2019 Mar 27. Epub 2019 Mar 27.

Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.

Background: Head and neck mucosal melanomas (MMs) are rare tumors with adverse outcomes and poorer prognoses than their more common cutaneous counterparts (cutaneous melanomas-CMs). Few studies have compared the expression of mitochondrial dynamic markers in these tumors. This study aimed to assess the correlations of mitochondrial markers with melanoma progression and their potential as predictors of lymph node involvement and distant metastasis. Read More

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http://dx.doi.org/10.1111/jop.12855DOI Listing
March 2019
1 Read

Pectoralis Major Myocutaneous Flap for the Reconstruction of the Palatal Defect.

Indian J Otolaryngol Head Neck Surg 2019 Mar 4;71(1):132-135. Epub 2018 Dec 4.

Department of ENT and Head Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, Odisha 751019 India.

It is always a challenge for the soft tissue reconstruction of the palatal defects in advanced malignancies of the oral cavity because of the higher chance flap failure. PMMC flap can be successfully used in patients with advanced malignancies to repair the palatal defect without any significant postoperative complication. In the present case, we have presented a case of malignant melanoma of gingivobuccal complex, involving the hard palate where the palatal defect was successfully reconstructed by the PMMC flap. Read More

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http://link.springer.com/10.1007/s12070-018-1547-5
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http://dx.doi.org/10.1007/s12070-018-1547-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401043PMC
March 2019
3 Reads

Transdermal metformin hydrochloride-loaded cubic phases: in silico formulation optimization, preparation, properties, and application for local treatment of melanoma.

Drug Deliv 2019 Dec;26(1):376-383

b Department of Pharmaceutical Sciences , Beijing Institute of Radiation Medicine , Beijing , China.

Metformin hydrochloride (Met) is commonly used for antidiabetic therapy though its antimelanoma action is also reported. Conventional oral administration method of Met is not appropriate for therapy of melanoma because of large dose, adverse reactions, and low efficiency. Here, a transdermal Met-loaded cubic phase was developed for local treatment of melanoma. Read More

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http://dx.doi.org/10.1080/10717544.2019.1587046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442100PMC
December 2019

Mineralocorticoid receptor negatively regulates angiogenesis through repression of STAT3 activity in endothelial cells.

J Pathol 2019 Mar 22. Epub 2019 Mar 22.

Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital, School of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200125, China.

The mineralocorticoid receptor (MR) plays important roles in cardiovascular pathogenesis. The function of MR in angiogenesis is still controversial. This study aimed to explore the role of endothelial MR in angiogenesis and to delineate the underlying mechanism. Read More

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http://dx.doi.org/10.1002/path.5269DOI Listing
March 2019
1 Read
7.429 Impact Factor

Phase 1/2 study of epacadostat in combination with ipilimumab in patients with unresectable or metastatic melanoma.

J Immunother Cancer 2019 Mar 20;7(1):80. Epub 2019 Mar 20.

Donald A. Adam Melanoma and Skin Cancer Research Center of Excellence, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, USA.

Background: Epacadostat is a potent inhibitor of the immunosuppressive indoleamine 2,3-dioxygenase 1 (IDO1) enzyme. We present phase 1 results from a phase 1/2 clinical study of epacadostat in combination with ipilimumab, an anti-cytotoxic T-lymphocyte-associated protein 4 antibody, in advanced melanoma (NCT01604889).

Methods: Only the phase 1, open-label portion of the study was conducted, per the sponsor's decision to terminate the study early based on the changing melanoma treatment landscape favoring exploration of programmed cell death protein 1 (PD-1)/PD-ligand 1 inhibitor-based combination strategies. Read More

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http://dx.doi.org/10.1186/s40425-019-0562-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425606PMC
March 2019
1 Read

Biological Activity and In Silico Study of 3-Modified Derivatives of Betulin and Betulinic Aldehyde.

Int J Mol Sci 2019 Mar 19;20(6). Epub 2019 Mar 19.

Medical University of Silesia in Katowice, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Department of Organic Chemistry, 4 Jagiellońska Str., 41-200 Sosnowiec, Poland.

A series of 3-substituted derivatives of betulin and betulinic aldehyde were synthesized as promising anticancer agents. The newly triterpenes were tested against five human cancer cell lines like biphenotypic B myelomonocytic leukaemia (MV-4-11), adenocarcinoma (A549), prostate (Du-145), melanoma (Hs294T), breast adenocarcinoma (MCF-7) and normal human mammary gland (MCF-10A). The compound showed towards Du-145, MCF-7 and Hs294T cells significant antiproliferative activity with IC ranging from 7. Read More

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http://dx.doi.org/10.3390/ijms20061372DOI Listing
March 2019
2 Reads

Synthesis of novel 7-azaindole derivatives containing pyridin-3-ylmethyl dithiocarbamate moiety as potent PKM2 activators and PKM2 nucleus translocation inhibitors.

Eur J Med Chem 2019 May 8;170:1-15. Epub 2019 Mar 8.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. Electronic address:

Multiple lines of evidence have indicated that pyruvate kinase M2 (PKM2) is upregulated in most cancer cells and it is increasingly recognized as a potential therapeutic target in oncology. In a continuation of our discovery of lead compound 5 and SAR study, the 7-azaindole moiety in compound 5 was systematically optimized. The results showed that compound 6f, which has a difluoroethyl substitution on the 7-azaindole ring, exhibited high PKM2 activation potency and anti-proliferation activities on A375 cell lines. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.03.003DOI Listing
May 2019
2 Reads

CD117 immunoexpression in oral and sinonasal mucosal melanoma does not correlate with somatic driver mutations in the MAPK pathway.

J Oral Pathol Med 2019 Mar 15. Epub 2019 Mar 15.

National Cancer Institute of Mexico, Mexico City, Mexico.

Background: Mutations on KIT and downstream genes of MAPK pathway that overstimulate cellular proliferation have been associated with primary oral and sinonasal melanomas (POSNM), but there is limited information that allows the use of personalized therapy. Thus, the aim of the present study was to determine a possible association between the C-KIT immunohistochemical expression with the presence of somatic driver mutations in NRAS, BRAF, KIT, MITF and PTEN on POSNM.

Methods: A retrospective study included 62 tumour samples of an oncological reference centre in Mexico City (17-year period). Read More

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http://dx.doi.org/10.1111/jop.12849DOI Listing
March 2019
2 Reads

Skin cancers in patients of skin phototype V or VI with xeroderma pigmentosum type C (XP-C): A retrospective study.

Ann Dermatol Venereol 2019 Mar 8;146(3):192-203. Epub 2019 Mar 8.

Service de dermatologie, CHU de La Réunion, 97400 Saint-Denis, La Réunion, France.

Background: Xeroderma pigmentosum (XP) is a rare genetic disease comprising 7 subgroups, A to G, all of which are associated with early onset of several forms of skin cancer. Our main objective was to determine the prevalence of skin cancers in a cohort of dark-skinned XP-C patients in Mayotte.

Patients And Methods: A single-centre cohort consisting of all XP patients was followed in the island of Mayotte from December 2015 to May 2017 by dermatologists from the University Hospital of Saint-Denis (Reunion) during the course of dermatological missions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01519638193003
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http://dx.doi.org/10.1016/j.annder.2018.11.013DOI Listing
March 2019
1 Read

Oral levodopa rescues retinal morphology and visual function in a murine model of human albinism.

Pigment Cell Melanoma Res 2019 Mar 9. Epub 2019 Mar 9.

Clinical and Experimental Sciences, Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton University Hospital, University of Southampton, Southampton, UK.

Albinism is a group of disorders characterized by pigment deficiency and abnormal retinal development. Despite being a common cause for visual impairment worldwide, there is a paucity of treatments and patients typically suffer lifelong visual disability. Residual plasticity of the developing retina in young children with albinism has been demonstrated, suggesting a post-natal window for therapeutic rescue. Read More

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http://dx.doi.org/10.1111/pcmr.12782DOI Listing
March 2019
1 Read

Do cognitive heuristics underpin symptom appraisal for symptoms of cancer?: A secondary qualitative analysis across seven cancers.

Psychooncology 2019 Mar 3. Epub 2019 Mar 3.

Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London.

Objectives: To explore the evidence for cognitive heuristics or "rules of thumb" used within patients' reports of symptom appraisal and decisions to seek help for symptoms of cancer.

Methods: A secondary analysis of interviews from existing studies that explored symptom appraisal in patients who had sought help for potential symptoms of cancer. Transcripts from n = 50 in-depth interviews with patients referred with symptoms suspicious of cancer (pancreas, colorectal, oral, lung, melanoma, breast, and prostate) were re-analysed using a deductive thematic approach underpinned by the heuristics outlined in the Common Sense Model of Illness Self-regulation as set within the Model of Pathways to Treatment. Read More

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http://dx.doi.org/10.1002/pon.5049DOI Listing
March 2019
3 Reads

Prognostic role of glycolysis for cancer outcome: evidence from 86 studies.

J Cancer Res Clin Oncol 2019 Apr 1;145(4):967-999. Epub 2019 Mar 1.

Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.

Objective: The abnormal expression of the key enzymes in glycolytic pathways, including glucose transporter-1, glucose transporter-3, hexokinase-II, lactate dehydrogenase 5, pyruvate kinase M2, glucose-6-phosphate dehydrogenase, transketolase-like protein 1 and pyruvate dehydrogenase kinase-1 was reported to be associated with poor prognosis of various cancers. However, the association remains controversial. The objective of this study was to investigate the prognostic significance of glycolysis-related proteins. Read More

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http://dx.doi.org/10.1007/s00432-019-02847-wDOI Listing
April 2019
2 Reads

Cancer incidence and mortality after heart transplantation - A population-based national cohort study.

Acta Oncol 2019 Mar 1:1-5. Epub 2019 Mar 1.

a Heart and Lung Center , Helsinki University Hospital , Helsinki , Finland.

Background: Cancer is currently one of the most important factors affecting the long-term health and survival of heart transplant patients.

Material And Methods: We calculated the standardized incidence ratios (SIR) for different cancer sites and the cancer-specific standardized mortality ratio (SMR) by linking a cohort of 479 adult heart transplant recipients transplanted in 1985-2014 (4491.6 person-years of follow-up) with data from the national Finnish Cancer Registry until the end of 2015, and with the data from the Statistics Finland's national registry of causes of death. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1580385DOI Listing
March 2019
2 Reads

Invasive melanoma in a 5-year-old Canadian patient: A case report.

SAGE Open Med Case Rep 2019 18;7:2050313X19829630. Epub 2019 Feb 18.

Division of Dermatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

Atypical Spitzoid lesions pose a distinct challenge in classification as they may comprise a mixture of both classic benign nevus and cutaneous melanoma characteristics. Immunostaining and molecular analysis, such as comparative genomic hybridization, can assist in narrowing the differential diagnosis. We present a case of a 5-year-old male with an atypical Spitzoid lesion on his back. Read More

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http://dx.doi.org/10.1177/2050313X19829630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381421PMC
February 2019
2 Reads

Reproductive factors, exogenous hormone use and incidence of melanoma among women in the United States.

Br J Cancer 2019 Apr 28;120(7):754-760. Epub 2019 Feb 28.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Rockville, MD, USA.

Background: Although the photosensitising effects of oestrogens may increase the impact of ultraviolet radiation (UVR) on melanoma risk, few prospective studies have comprehensively assessed the association between oestrogen-related factors and melanoma.

Methods: We examined the associations between reproductive factors, exogenous oestrogen use and first primary invasive melanoma among 167 503 non-Hispanic white, postmenopausal women in the NIH-AARP Diet and Health Study. Satellite-based ambient UVR estimates were linked to geocoded residential locations of participants at study baseline. Read More

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http://dx.doi.org/10.1038/s41416-019-0411-zDOI Listing
April 2019
4 Reads

A multicenter study of body mass index in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors: when overweight becomes favorable.

J Immunother Cancer 2019 Feb 27;7(1):57. Epub 2019 Feb 27.

Department of Medical, Oral & Biotechnological Sciences University G. D'Annunzio, Chieti-Pescara, Italy.

Background: Recent evidence suggested a potential correlation between overweight and the efficacy of immune checkpoint inhibitors (ICIs) in cancer patients.

Patients And Methods: We conducted a retrospective study of advanced cancer patients consecutively treated with anti-PD-1/PD-L1 inhibitors, in order to compare clinical outcomes according to baseline BMI levels as primary analysis. Based on their BMI, patients were categorized into overweight/obese (≥ 25) and non-overweight (< 25). Read More

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http://dx.doi.org/10.1186/s40425-019-0527-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391761PMC
February 2019
1 Read

Cellular delivery and enhanced anticancer activity of berberine complexed with a cationic derivative of γ-cyclodextrin.

Bioorg Med Chem 2019 Apr 21;27(7):1414-1420. Epub 2019 Feb 21.

Jagiellonian University, Faculty of Chemistry, Gronostajowa 2, 30-387 Kraków, Poland. Electronic address:

A cationic derivative of γ-cyclodextrin (GCD) modified with propylenediamine (PDA) was synthesized. It was shown that the derivative (GCD-PDA) is mucoadhesive and resistant to the digestion with ∝-amylase indicating that it may constitute an efficient oral delivery vehicle. GCD-PDA formed an inclusion complex with berberine (BBR), an alkaloid displaying a multitude of beneficial physiological effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09680896193009
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http://dx.doi.org/10.1016/j.bmc.2019.02.042DOI Listing
April 2019
5 Reads

Ventral Mandibulectomy for removal of oral tumors in the dog: Surgical technique and results in 19 cases.

Vet Comp Oncol 2019 Feb 22. Epub 2019 Feb 22.

Department of Small Animal Clinical Sciences, University of Florida, Florida.

The purpose of this retrospective study is to describe in detail a novel ventral approach for mandibulectomy and the results in 19 dogs. The medical records of 19 dogs that received a partial or total unilateral mandibulectomy with the new ventral approach were reviewed. Information obtained included: signalment, tumor type, extent of mandibulectomy, removal of regional lymph nodes, intra-surgical complications, immediate post-operative complications, histopathological diagnosis and study of margins. Read More

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http://dx.doi.org/10.1111/vco.12472DOI Listing
February 2019

Anti-metastatic Properties of Naproxen-HBTA in a Murine Model of Cutaneous Melanoma.

Front Pharmacol 2019 8;10:66. Epub 2019 Feb 8.

Department of Pharmacy, University of Naples Federico II, Naples, Italy.

The beneficial effects of HS-release and of COXs-inhibition have been exploited in the design of novel anti-inflammatory drugs, the HS-releasing non-steroidal anti-inflammatory drugs (HS-NSAIDs), showing promising potential for chemoprevention in cancers. Here, we evaluated the efficacy of a new HS-releasing derivative of naproxen, named naproxen-4-hydroxybenzodithioate (naproxen-HBTA), in reducing metastatic melanoma features, both and . The novel HS donor has been prepared following a synthetic scheme that provided high yields and purity. Read More

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http://dx.doi.org/10.3389/fphar.2019.00066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376415PMC
February 2019

Clinical Outcomes of Patients with Advanced Cancer and Pre-Existing Autoimmune Diseases Treated with Anti-Programmed Death-1 Immunotherapy: A Real-World Transverse Study.

Oncologist 2019 Feb 22. Epub 2019 Feb 22.

Medical Oncology, St. Salvatore Hospital, L'Aquila, Italy.

Background: Patients with a history of autoimmune diseases (AIDs) have not usually been included in clinical trials with immune checkpoint inhibitors.

Materials And Methods: Consecutive patients with advanced cancer, treated with anti-programmed death-1 (PD-1) agents, were evaluated according to the presence of pre-existing AIDs. The incidence of immune-related adverse events (irAEs) and clinical outcomes were compared among subgroups. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0618DOI Listing
February 2019
3 Reads
4.865 Impact Factor

Analysis of mucosal melanoma whole-genome landscapes reveals clinically relevant genomic aberrations.

Clin Cancer Res 2019 Feb 19. Epub 2019 Feb 19.

Shanghai Key Laboratory of Stomatology, Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine

Purpose: Unlike advances in the genomics-driven precision treatment of cutaneous melanomas, the poor current understanding of the molecular basis of mucosal melanomas (MMs) has hindered such progress for MM patients. Thus, we sought to characterize the genomic landscape of MM to identify genomic alterations with prognostic and/or therapeutic implications.

Experimental Design: Whole-genome sequencing (WGS) was performed on 65 MM samples, including 63 paired tumor blood samples and 2 matched lymph node metastases, with a further ddPCR-based validation study of an independent MM cohort (n = 80). Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-3442DOI Listing
February 2019
18 Reads
8.722 Impact Factor

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK.

Cancer Cell 2019 Mar 14;35(3):457-472.e5. Epub 2019 Feb 14.

Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

Activating mutations in GNAQ/GNA11, encoding Gαq G proteins, are initiating oncogenic events in uveal melanoma (UM). However, there are no effective therapies for UM. Using an integrated bioinformatics pipeline, we found that PTK2, encoding focal adhesion kinase (FAK), represents a candidate synthetic lethal gene with GNAQ activation. Read More

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http://dx.doi.org/10.1016/j.ccell.2019.01.009DOI Listing
March 2019
1 Read
23.523 Impact Factor

Case series of dabrafenib-trametinib-induced pyrexia successfully treated with colchicine.

Support Care Cancer 2019 Feb 14. Epub 2019 Feb 14.

Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

The most common adverse event (AE) of dabrafenib and trametinib (DT) is pyrexia, which has been reported to occur in up to 71% of patients. Pyrexia resulted in therapy discontinuation in up to 26% of patients that otherwise were benefiting from the treatment. Little is known about the pathogenesis and optimal management of this common AE. Read More

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http://dx.doi.org/10.1007/s00520-019-4654-2DOI Listing
February 2019
1 Read

A Review of Immunotherapeutic Strategies in Canine Malignant Melanoma.

Vet Sci 2019 Feb 12;6(1). Epub 2019 Feb 12.

Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, Grafton, MA 01536, USA.

In dogs, melanomas are relatively common tumors and the most common form of oral malignancy. Biological behavior is highly variable, usually aggressive, and frequently metastatic, with reported survival times of three months for oral or mucosal melanomas in advanced disease stages. Classical clinical management remains challenging; thus, novel and more efficacious treatment strategies are needed. Read More

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http://www.mdpi.com/2306-7381/6/1/15
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http://dx.doi.org/10.3390/vetsci6010015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466282PMC
February 2019
4 Reads

Metformin Treatment Suppresses Melanoma Cell Growth and Motility Through Modulation of microRNA Expression.

Cancers (Basel) 2019 Feb 11;11(2). Epub 2019 Feb 11.

Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.

Melanoma is a highly aggressive cancer with high mortality in advanced stages.Metformin is an oral biguanide drug used for diabetes and has demonstrated positive effects oncancer prevention and treatment. Herein, we found that metformin significantly suppressedmelanoma cancer cell motility and growth through inducing cell cycle arrest at the G2/M phase andpromoting cell apoptosis. Read More

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http://dx.doi.org/10.3390/cancers11020209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406940PMC
February 2019
5 Reads

Oral mycosis fungoides with CD30 large cell transformation successfully treated with brentuximab vedotin.

JAAD Case Rep 2019 Feb 30;5(2):180-183. Epub 2019 Jan 30.

Georgetown University School of Medicine, Department of Dermatology, Washington, DC.

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https://linkinghub.elsevier.com/retrieve/pii/S23525126183034
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http://dx.doi.org/10.1016/j.jdcr.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357896PMC
February 2019
8 Reads

IFN regulatory factor-8 expression in macrophages governs an antimetastatic program.

JCI Insight 2019 Feb 7;4(3). Epub 2019 Feb 7.

Department of Immunology.

High macrophage infiltration in cancer is associated with reduced survival in animal models and in patients. This reflects a shift in the macrophage response from a tumor-suppressive to tumor-supportive program governed by transcriptional events regulated by the inflammatory milieu. Although several transcription factors are known to drive a prometastatic program, those that govern an antimetastatic program are less understood. Read More

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https://insight.jci.org/articles/view/124267
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http://dx.doi.org/10.1172/jci.insight.124267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413790PMC
February 2019
7 Reads

Afterword: Oral Methioninase-Answer to Cancer and Fountain of Youth?

Methods Mol Biol 2019 ;1866:311-322

AntiCancer, Inc., San Diego, CA, USA.

The elevated methionine (MET) requirement of cancer cells is termed MET dependence and is possibly the only known general metabolic defect in cancer. Targeting MET by recombinant methioninase (rMETase) can arrest the growth of cancer cells in vitro and in vivo due to their elevated requirement for MET. rMETase can also potentiate chemotherapy drugs active in S phase due to the selective arrest of cancer cells in S/G phase during MET restriction (MR). Read More

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http://link.springer.com/10.1007/978-1-4939-8796-2_24
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http://dx.doi.org/10.1007/978-1-4939-8796-2_24DOI Listing
January 2019
12 Reads

Canine oral primary melanoma cells exhibit shift to mesenchymal phenotype and phagocytic behaviour.

Vet Comp Oncol 2019 Feb 4. Epub 2019 Feb 4.

Research Group Oncology (RGO), Equine Surgery, Department for Small Animals and Horses, University of Veterinary Medicine, Vienna, Austria.

Canine oral malignant melanoma (COMM) is a potentially lethal cancer disease. We established primary cell lines from mostly amelanotic primary COMM and metastases and assessed lesions and derived cells for Melan A, PNL2 and CD146 expression. Then, migration and invasion of CD146-enriched versus -depleted COMM cells were analysed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/vco.12464
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http://dx.doi.org/10.1111/vco.12464DOI Listing
February 2019
10 Reads

Transducin-like enhancer of split 3 regulates proliferation of melanoma cells via histone deacetylase activity.

Oncotarget 2019 Jan 8;10(3):404-414. Epub 2019 Jan 8.

Division of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Fukuoka, Japan.

Melanoma, one of the most aggressive neoplasms, is characterized by rapid cell proliferation. Transducin-like Enhancer of Split (TLE) is an important regulator of cell proliferation via Histone deacetylase (HDAC) recruitment. Given that HDAC activity is associated with melanoma progression, we examined the relationship between TLE3, a TLE family member, and melanoma. Read More

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http://dx.doi.org/10.18632/oncotarget.26552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349449PMC
January 2019
1 Read

Association Between Cancer Incidence and Mortality in Web-Based Data in China: Infodemiology Study.

J Med Internet Res 2019 Jan 29;21(1):e10677. Epub 2019 Jan 29.

School of Public Health, Tianjin Medical University, Tianjin, China.

Background: Cancer poses a serious threat to the health of Chinese people, resulting in a major challenge for public health work. Today, people can obtain relevant information from not only medical workers in hospitals, but also the internet in any place in real-time. Search behaviors can reflect a population's awareness of cancer from a completely new perspective, which could be driven by the underlying cancer epidemiology. Read More

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http://dx.doi.org/10.2196/10677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371071PMC
January 2019
3 Reads
3.428 Impact Factor

Clinicopathological study of malignant melanoma in a regional cancer center.

Indian J Cancer 2018 Jul-Sep;55(3):292-296

Department of Pathology, A.H. Regional Cancer Centre, Cuttack, Odisha, India.

Background: : Malignant melanoma is a tumor of melanocytic origin. Although uncommon in India as compared with the west, its prevalence is increasing.

Objectives: To document the pattern of clinicopathological features of malignant melanoma cases attending in a regional cancer center in eastern India. Read More

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http://dx.doi.org/10.4103/ijc.IJC_612_17DOI Listing
January 2019
7 Reads