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    INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology.
    ACS Med Chem Lett 2017 May 6;8(5):486-491. Epub 2017 Mar 6.
    Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
    A data-centric medicinal chemistry approach led to the invention of a potent and selective IDO1 inhibitor 4f, INCB24360 (epacadostat). The molecular structure of INCB24360 contains several previously unknown or underutilized functional groups in drug substances, including a hydroxyamidine, furazan, bromide, and sulfamide. These moieties taken together in a single structure afford a compound that falls outside of "drug-like" space. Read More

    Two Cases of Nivolumab Re-Administration after Pneumonitis as Immune-Related Adverse Events.
    Case Rep Oncol 2017 Jan-Apr;10(1):296-300. Epub 2017 Apr 4.
    bDepartment of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Nivolumab is a recently approved medication for the treatment of unresectable malignant melanoma. Many immune-related adverse events (irAEs) associated with nivolumab have been reported, such as pneumonitis, hepatitis, dermatitis, and thyroiditis. Prednisolone can effectively treat irAEs. Read More

    Antibiotics-induced gut microbiota dysbiosis promotes tumor initiation via affecting APC-Th1 development in mice.
    Biochem Biophys Res Commun 2017 May 12. Epub 2017 May 12.
    State Key Laboratory of Cancer Biology, Department of Pharmacogenomics, Fourth Military Medical University, Xi'an 710032, PR China. Electronic address:
    Gut microbiota is critical for maintaining body immune homeostasis and thus affects tumor growth and therapeutic efficiency. Here, we investigated the link between microbiota and tumorgenesis in a mice model of subcutaneous melanoma cell transplantation, and explored the underlying mechanism. We found disruption of gut microbiota by pretreating mice with antibiotics promote tumor growth and remodeling the immune compartment within the primary tumor. Read More

    Anti-tumor effects of differentiation-inducing factor-1 in malignant melanoma: GSK-3-mediated inhibition of cell proliferation and GSK-3-independent suppression of cell migration and invasion.
    Biochem Pharmacol 2017 May 10. Epub 2017 May 10.
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
    Differentiation-inducing factor-1 (DIF-1) isolated from Dictyostelium discoideum strongly inhibits the proliferation of various mammalian cells through the activation of glycogen synthase kinase-3 (GSK-3). To evaluate DIF-1 as a novel anti-cancer agent for malignant melanoma, we examined whether DIF-1 has anti-proliferative, anti-migratory, and anti-invasive effects on melanoma cells using in vitro and in vivo systems. DIF-1 reduced the expression levels of cyclin D1 and c-Myc by facilitating their degradation via GSK-3 in mouse (B16BL6) and human (A2058) malignant melanoma cells, and thereby strongly inhibited their proliferation. Read More

    Paraneoplastic acral vascular syndrome in a patient with metastatic melanoma under immune checkpoint blockade.
    BMC Cancer 2017 May 12;17(1):327. Epub 2017 May 12.
    Department of Dermatology, Ruhr-University Bochum, Gudrunstr. 56, 44791, Bochum, Germany.
    Background: Paraneoplastic acral vascular syndrome (PAVS) is a rare phenomenon which is observed in patients with adenocarcinomas and other malignancies. Various potential pathogenic mechanisms such as tumour invasion of sympathetic nerves, hyperviscosity, hypercoagulability, vasoactive tumour-secreted substances, and immunological mechanisms have been suggested.

    Case Presentation: We report a 60-year-old Caucasian male attended our hospital with a bulky lymph node mass in the right axilla. Read More

    Risk of Second Primary Cancer in People with Non-Melanoma Skin Cancer: A Nationwide Cohort Study.
    Cancer Res Treat 2017 May 10. Epub 2017 May 10.
    Department of Medical Research and Education, Cheng Hsin General Hospital, Taipei, Taiwan.
    Purpose: Previous western studies have found Caucasians with skin cancer, either melanoma or non-melanoma skin cancer (NMSC), have an elevated risk of second primary cancer. Our objective was to assess the risk of second primary cancer in Taiwanese with NMSC.

    Materials And Methods: By using data from Taiwan's National Health Insurance Research Database, we conducted a population-based cohort study to assess the risk of incident second primary cancer in Taiwanese affected by NMSC. Read More

    Cutaneous melanoma in women.
    Int J Womens Dermatol 2017 Mar 16;3(1 Suppl):S11-S15. Epub 2017 Feb 16.
    Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
    Background: Gender disparity in melanoma outcome is consistently observed, suggesting that gender is as an important prognostic factor. However, the source of this gender disparity in melanoma remains unclear.

    Objective: This article reviews advances in our understanding of gender differences in melanoma and how such differences may contribute to outcomes. Read More

    Extensions to Multivariate Space Time Mixture Modeling of Small Area Cancer Data.
    Int J Environ Res Public Health 2017 May 9;14(5). Epub 2017 May 9.
    Interuniversity Institute for Statistics and Statistical Bioinformatics, Hasselt University, 3500 Hasselt, Belgium.
    Oral cavity and pharynx cancer, even when considered together, is a fairly rare disease. Implementation of multivariate modeling with lung and bronchus cancer, as well as melanoma cancer of the skin, could lead to better inference for oral cavity and pharynx cancer. The multivariate structure of these models is accomplished via the use of shared random effects, as well as other multivariate prior distributions. Read More

    Synthesis of Europium-Doped Fluorapatite Nanorods and Their Biomedical Applications in Drug Delivery.
    Molecules 2017 May 6;22(5). Epub 2017 May 6.
    Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
    Europium (Eu)-doped fluorapatite (FA) nanorods have a biocompatibility similar to that of hydroxyapatite (HA) for use as cell imaging biomaterials due to their luminescent property. Here, we discuss the new application of europium-doped fluorapatite (Eu-FA) nanorods as an anticancer drug carrier. The Eu-FA nanorods were prepared by using a hydrothermal method. Read More

    Presage of oncolytic virotherapy for oral cancer with herpes simplex virus.
    Jpn Dent Sci Rev 2017 May 5;53(2):53-60. Epub 2016 Nov 5.
    Department of Oral and Maxillofacial Surgery II, Osaka University, Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan.
    A virus is a pathogenic organism that causes a number of infectious diseases in humans. The oral cavity is the site at which viruses enter and are excreted from the human body. Herpes simplex virus type 1 (HSV-1) produces the primary infectious disease, gingivostomatitis, and recurrent disease, labial herpes. Read More

    Genetic association between TNF-α promoter polymorphism and susceptibility to squamous cell carcinoma, basal cell carcinoma, and melanoma: A meta-analysis.
    Oncotarget 2017 Apr 18. Epub 2017 Apr 18.
    Department of General Surgery, Bailou Hospital, Tianjin 300040, PR China.
    Tumor necrosis factor-alpha (TNF-α) is a multifunctional pro-inflammatory cytokine that plays an important role in cancer development. We performed a meta-analysis to assess the relationship between single nucleotide polymorphisms in the TNF-α promoter region (rs1800629 and rs361525) and susceptibility to squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and melanoma. After database retrieval, article selection, data extraction, and quality assessment, 20 articles comprising 4865 cases and 6329 controls were included in this study. Read More

    Combining DNA Vaccine and AIDA-1 in Attenuated Salmonella Activates Tumor-Specific CD4(+) and CD8(+) T-cell Responses.
    Cancer Immunol Res 2017 May 3. Epub 2017 May 3.
    Immunology Programme, Life Sciences Institute and Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
    Stimulation of tumor-specific responses in both CD4(+) and CD8(+) T cells has been a challenge for effective tumor vaccines. We designed a vaccine vector containing the AIDA-1 autotransporter and DNA vaccine elements, generating a murine melanoma vaccine that was delivered by the attenuated Salmonella strain SL7207. Growth of murine subcutaneous melanoma was significantly inhibited by intranasal immunization with the Salmonella tumor vaccine. Read More

    Prevention of non-melanoma skin cancers with nicotinamide in transplant recipients: a case-control study.
    Eur J Dermatol 2017 May 3. Epub 2017 May 3.
    Department of Dermatology, IRCCS AOU San Martino IST, Largo R. Benzi, 10, 16132 Genoa, Italy.
    Nicotinamide is the precursor of nicotinamide adenine dinucleotide (NAD+), an essential cofactor for adenosine triphosphate (ATP) production. It has recently been reported to be effective in reducing the rates of new non-melanoma skin cancers (NMSCs) and actinic keratosis (AKs). We studied the efficacy of oral nicotinamide as treatment for AKs in transplant recipients. Read More

    Primary giant aggressive amelanotic duodenal melanoma.
    Ann R Coll Surg Engl 2017 May;99(5):e131-e134
    All India Institute of Medical Sciences , New Delhi , India.
    Primary malignant melanoma of the gastrointestinal tract is extremely rare. A 35-year-old man presented with complaints of abdominal pain and weight loss. Contrast enhanced computed tomography showed a large mass involving the duodenum and the superior mesenteric vessels. Read More

    IQGAP1 is an oncogenic target in canine melanoma.
    PLoS One 2017 26;12(4):e0176370. Epub 2017 Apr 26.
    Program in Epithelial Biology, Stanford University, Stanford, California, United States of America.
    Canine oral mucosal melanoma is an aggressive malignant neoplasm and is characterized by local infiltration and a high metastatic potential. The disease progression is similar to that of human oral melanomas. Whereas human cutaneous melanoma is primarily driven by activating mutations in Braf (60%) or Nras (20%), human mucosal melanoma harbors these mutations much less frequently. Read More

    Congenital amelanotic melanoma in a crossbred heifer calf.
    J Vet Diagn Invest 2017 Apr 1:1040638717706399. Epub 2017 Apr 1.
    Departments of Veterinary Clinical Sciences (Winslow, Gilliam), Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK.
    A large, pedunculated cutaneous mass protruding from the left flank fold and an enlarged left prefemoral lymph node were found on examination of a 3-d-old crossbred Aberdeen Angus heifer. The calf was asymptomatic aside from peripheral lymphadenopathy, and the mass, along with the left prefemoral lymph node, was surgically excised. Histologic examination of the mass and the lymph node revealed a homogeneous population of neoplastic cells that stained positively with immunohistochemical stains S100 and melan A, supporting a diagnosis of congenital amelanotic melanoma with nodal metastasis. Read More

    Targeting HOX/PBX dimers in cancer.
    Oncotarget 2017 May;8(19):32322-32331
    Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
    The HOX and PBX gene families encode transcription factors that have key roles in establishing the identity of cells and tissues in early development. Over the last 20 years it has become apparent that they are also dysregulated in a wide range of solid and haematological malignancies and have a predominantly pro-oncogenic function. A key mode of transcriptional regulation by HOX and PBX proteins is through their interaction as a heterodimer or larger complex that enhances their binding affinity and specificity for DNA, and there is growing evidence that this interaction is a potential therapeutic target in malignancies that include prostate, breast, renal, ovarian and lung cancer, melanoma, myeloma, and acute myeloid leukaemia. Read More

    Oral pigmentations in physiologic conditions, post inflammatory affections and systemic diseases.
    G Ital Dermatol Venereol 2017 Apr 19. Epub 2017 Apr 19.
    Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy -
    Melanocytes are found throughout the oral mucosa but usually go unnoticed because of their relatively low level of pigment production. When focally or generally active in pigment production or proliferation they may be responsible for several affections in the oral mucosae ranging from physiologic pigmentation, systemic diseases to malignant neoplasms. The diagnosis of oral pigmentations (OP) is usually challenging for the physician, but a careful examination of the oral cavity may reveal the first manifestation of underlying systemic diseases. Read More

    Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors.
    Oncotarget 2017 Mar 15. Epub 2017 Mar 15.
    G1 Therapeutics, Preclinical Research and Development, Research Triangle Park, North Carolina, USA.
    Inhibition of the p16INK4a/cyclin D/CDK4/6/RB pathway is an effective therapeutic strategy for the treatment of estrogen receptor positive (ER+) breast cancer. Although efficacious, current treatment regimens require a dosing holiday due to severe neutropenia potentially leading to an increased risk of infections, as well as tumor regrowth and emergence of drug resistance. Therefore, a next generation CDK4/6 inhibitor that can inhibit proliferation of CDK4/6-dependent tumors while minimizing neutropenia could reduce both the need for treatment holidays and the risk of inducing drug resistance. Read More

    Autoimmune Diabetes Presented with Diabetic Ketoacidosis Induced by Immunotherapy in an Adult with Melanoma.
    J La State Med Soc 2017 Mar-Apr;169(2):49. Epub 2017 Apr 15.
    Department of Internal Medicine, Ochsner Medical Center in New Orleans, LA.
    Introduction: Immunotherapy has been approved for treatment of melanoma. Autoimmune endocrinopathies have been reported in trials involving immunotherapy but autoimmune diabetes has not been definitively linked to them. Here we describe a case of autoimmune diabetes presenting with DKA after receiving combined immunotherapy with anti-CTLA4 and anti-PD1 monoclonal antibodies. Read More

    Cytokine profiles of amyopathic dermatomyositis with interstitial lung diseases treated with mycophenolate.
    Respirol Case Rep 2017 Jul 11;5(4):e00235. Epub 2017 Apr 11.
    Division of Respiratory MedicineNiigata University Medical and Dental HospitalNiigataJapan.
    A 59-year-old Japanese man diagnosed with interstitial lung disease associated with amyopathic dermatomyositis with anti-melanoma differentiation-associated gene 5 (MDA-5) antibodies was treated with intravenous methyl prednisolone (PSL) 1000 mg, oral PSL 1 mg/kg, and oral cyclosporin 200 mg daily. His respiratory condition worsened after treatment with two times of intravenous cyclophosphamide and another steroid pulse therapy as well as PSL and cyclosporin. Addition of mycophenolate mofetil (MMF), 1. Read More

    Mucoepidermoid carcinoma with extensive spindled morphology and melanocytic marker expression.
    Hum Pathol 2017 Apr 12. Epub 2017 Apr 12.
    Department of Diagnostic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Pathology, Chiba University Hospital, Chiba, Japan.
    Mucoepidermoid carcinoma (MEC) is the most common malignant neoplasm of the salivary gland. Albeit common, histological variants have rarely been noted in MEC. Here, we report a 49-year-old man with a sublingual gland tumor. Read More

    [Pigmentations of the oral cavity].
    Presse Med 2017 Mar 12;46(3):303-319. Epub 2017 Apr 12.
    Institut universitaire du cancer, Toulouse Oncopole 1, oncodermatologie et consultation pluridisciplinaire de pathologies buccales, avenue Irène-Joliot-Curie, 31100 Toulouse, France.
    Buccal mucosa color is explained by hemoglobin in the vessels and melanin in the epithelium. Abnormal presence of melanin pigments (hypermelaninosis, hypermelanocytosis), hematic pigments (hemoglobin, hemosiderin, iron) but also some exogenous circonstancies explain pigmented lesions (figure 1). These lesions could be localized (single lesions), multifocal (multiple lesions) or diffused. Read More

    RNA in Salivary Extracellular Vesicles as a Possible Tool for Systemic Disease Diagnosis.
    J Dent Res 2017 Apr 1:22034517702100. Epub 2017 Apr 1.
    1 School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, Republic of Korea.
    Saliva contains biological information as blood and is recognized as a valuable diagnostic medium for their noninvasiveness. Although "-omics" researches have tried to investigate saliva, the origin and significance of its contents are not clear, and its usage is largely confined to oral disease in the diagnostic and prognostic field. In an attempt to broaden the applicability of saliva and to find systemic disease-derived RNA in saliva, we made mouse models that had human melanoma and isolated extracellular vesicles (EVs) from their saliva by an aqueous 2-phase system (ATPS), then identified and evaluated their expression of human melan-A RNA, which is associated with melanoma on skin. Read More

    Erlotinib and bevacizumab in patients with advanced non-small-cell lung cancer and activating EGFR mutations (BELIEF): an international, multicentre, single-arm, phase 2 trial.
    Lancet Respir Med 2017 May 10;5(5):435-444. Epub 2017 Apr 10.
    University Hospital Zurich, Clinic of Oncology, Zurich, Switzerland; Swiss Group of Clinical Cancer Research, Bern, Switzerland. Electronic address:
    Background: The tyrosine kinase inhibitor erlotinib improves the outcomes of patients with advanced non-small-cell lung carcinoma (NSCLC) harbouring epidermal growth factor receptor (EGFR) mutations. The coexistence of the T790M resistance mutation with another EGFR mutation in treatment-naive patients has been associated with a shorter progression-free survival to EGFR inhibition than in the absence of the T790M mutation. To test this hypothesis clinically, we developed a proof-of-concept study, in which patients with EGFR-mutant NSCLC were treated with the combination of erlotinib and bevacizumab, stratified by the presence of the pretreatment T790M mutation. Read More

    Oral delivery of tumor microparticle vaccines activates NOD2 signaling pathway in ileac epithelium rendering potent antitumor T cell immunity.
    Oncoimmunology 2017 19;6(3):e1282589. Epub 2017 Jan 19.
    Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; Department of Biochemistry & Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China; Clinical Immunology Center, Chinese Academy of Medical Sciences, Beijing, China.
    Exploiting gut mucosal immunity to design new antitumor vaccination strategy remains unexplored. Tumor cell-derived microparticles (T-MP) are natural biomaterials that are capable of delivering tumor antigens and innate signals to dendritic cells (DC) for tumor-specific T cell immunity. Here, we show that T-MPs by oral vaccination route effectively access and activate mucosal epithelium, leading to subsequent antitumor T cell responses. Read More

    Loss of nuclear BAP1 expression is associated with poor prognosis in oral mucosal melanoma.
    Oncotarget 2017 Apr;8(17):29080-29090
    Department of Oral & Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200011, China.
    Oral mucosal melanoma (OMM) is an aggressive neoplasm with an extremely poor prognosis. BAP1 is a tumor suppressor that has been associated with the outcome of melanomas and other malignancies. In this study, we investigated the genetic alterations in BAP1 and the prognostic potential of BAP1 protein expression in oral mucosal melanoma. Read More

    Common Polymorphisms in the IFI16 and AIM2 Genes are Associated With Periodontal Disease.
    J Periodontol 2017 Apr 7:1-15. Epub 2017 Apr 7.
    Department of Periodontology, School of Dentistry, University of North Carolina at Chapel hill, Chapel Hill, NC, USA.
    Background: We investigated the single nucleotide polymorphism (SNP) context of a previously identified periodontitis-associated locus and examined its association with microbial, biological and periodontal disease clinical parameters.

    Methods: We annotated a 200Kb-spanning region of 1q12 previously highlighted in a genome-wide association scan among 4,910 European American individuals (SNP rs1633266). Two haplotype blocks were selected. Read More

    Differentiation by NK cells is a prerequisite for effective targeting of cancer stem cells/poorly differentiated tumors by chemopreventive and chemotherapeutic drugs.
    J Cancer 2017 11;8(4):537-554. Epub 2017 Feb 11.
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, The Jonsson Comprehensive Cancer Center, Dental Research Institute, Division of Oral Biology and Oral Medicine. UCLA School of Dentistry, Los Angeles, CA 90095, USA.
    Natural Killer (NK) cells target oral, pancreatic, lung, breast, glioblastoma and melanoma stem-like/poorly differentiated tumors. Differentiation of the abovementioned tumors with supernatants from split-anergized NK cells decreases their susceptibility to NK cells, but increases their sensitivity to cisplatin (CDDP)-mediated cell death. Breast and melanoma tumor cells with CD44 knockdown display enhanced susceptibility to NK cell-mediated lysis, potentially due to decreased differentiation. Read More

    Retinitis Pigmentosa and Other Dystrophies.
    Dev Ophthalmol 2017 28;58:191-201. Epub 2017 Mar 28.
    Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal degenerations characterized by progressive degeneration of rod and cone cells that affects predominantly peripheral visual fields. Macular edema may cause additional central visual acuity decrease. Cystoid macular edema (CME) is one of the few treatable causes of visual loss in RP. Read More

    Agreement Between Cytology and Histopathology for Regional Lymph Node Metastasis in Dogs With Melanocytic Neoplasms.
    Vet Pathol 2017 Jan 1:300985817698209. Epub 2017 Jan 1.
    1 Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
    Melanocytic neoplasms are common in dogs and frequently occur within the oral cavity or in haired skin. The behavior of melanocytic neoplasms is variable and depends on tumor location, size, and histopathologic features. This study compared cytopathology and histopathology of 32 lymph nodes from 27 dogs diagnosed with melanocytic neoplasms. Read More

    A phase 2 trial of dasatinib in patients with locally advanced or stage IV mucosal, acral, or vulvovaginal melanoma: A trial of the ECOG-ACRIN Cancer Research Group (E2607).
    Cancer 2017 Mar 23. Epub 2017 Mar 23.
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
    Background: KIT-directed tyrosine kinase inhibitors such as imatinib have demonstrated benefits in KIT-mutant (KIT+) mucosal, acral, vulvovaginal, and chronically sun-damaged (CSD) melanoma. Dasatinib has superior preclinical activity in comparison with other tyrosine kinase inhibitors against cells with the most common KIT mutation, exon 11(L576P) . The ECOG-ACRIN E2607 trial assessed dasatinib in patients with these melanoma subtypes. Read More

    Multicenter Study of Carbon-Ion Radiation Therapy for Mucosal Melanoma of the Head and Neck: Subanalysis of the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS) Study (1402 HN).
    Int J Radiat Oncol Biol Phys 2017 Apr 26;97(5):1054-1060. Epub 2016 Dec 26.
    Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.
    Purpose: To evaluate the efficacy and safety of carbon-ion radiation therapy (RT) for mucosal melanoma of the head and neck (MMHN) in the Japan Carbon-Ion Radiation Oncology Study Group study.

    Methods And Materials: Patients with MMHN with N0-1M0 status who were treated with carbon-ion RT at 4 institutions in Japan between November 2003 and December 2014 were analyzed retrospectively. Two hundred sixty patients (male, 111; female, 149; median age, 68 years) with histologically proven MMHN were enrolled. Read More

    Determining the epidemiologic, outcome, and prognostic factors of oral malignant melanoma by using the Surveillance, Epidemiology, and End Results database.
    J Am Dent Assoc 2017 May 18;148(5):288-297. Epub 2017 Mar 18.
    Background: The authors conducted a retrospective analysis to determine the epidemiologic, outcome, and prognostic factors in patients with oral malignant melanoma (OMM).

    Methods: The authors used the US National Cancer Institute's Surveillance, Epidemiology, and End Results database to analyze patients with OMM from 1973 to 2012. Study variables included age, sex, race, decade of diagnosis, extent of disease, tumor size, treatment modality, and socioeconomic status (SES). Read More

    Mucosal melanoma of the head and neck.
    Crit Rev Oncol Hematol 2017 Apr 13;112:136-152. Epub 2017 Feb 13.
    Department Melanoma, Soft Tissues, Musculoskeletal and Head & Neck, Italian National Cancer Institute - IRCCS Pascale Foundation, Naples, Italy.
    Mucosal melanoma of the head and neck is a very rare and aggressive malignancy with a very poor prognosis. The nasal cavity, paranasal sinuses, and oral cavity are the most common locations. One-, 3- and 5-year survival rates between 2000 and 2007 were 63%, 30% and 20%, respectively. Read More

    Comparing Outcomes between Antibody Induction Therapies in Kidney Transplantation.
    J Am Soc Nephrol 2017 Mar 20. Epub 2017 Mar 20.
    Renal Electrolyte and Hypertension Division, Department of Medicine, and
    Kidney transplant recipients often receive antibody induction. Previous studies of induction therapy were often limited by short follow-up and/or absence of information about complications. After linking Organ Procurement and Transplantation Network data with Medicare claims, we compared outcomes between three induction therapies for kidney recipients. Read More

    Further evidence for specific IFIH1 mutation as a cause of Singleton-Merten syndrome with phenotypic heterogeneity.
    Am J Med Genet A 2017 May 20;173(5):1396-1399. Epub 2017 Mar 20.
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
    Singleton-Merten syndrome (MIM 182250) is an autosomal dominant inherited disorder characterized by early onset periodontitis, root resorption, osteopenia, osteoporosis, and aortic valve or thoracic aorta calcification. The disorder can have significant intrafamilial phenotypic variability. Here, we present a mother and daughter with Singleton-Merten syndrome harboring a previously described pathogenic missense mutation, c. Read More

    Tetra-2,3-pyrazinoporphyrazines with externally appended pyridine rings. 17. Photosensitizing properties and cellular effects of Zn(II) octacationic and Zn(II)/Pt(II) hexacationic macrocycles in aqueous media: Perspectives of multimodal anticancer potentialities.
    J Photochem Photobiol B 2017 Apr 9;169:101-109. Epub 2017 Mar 9.
    Centre for Cutaneous Research, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK. Electronic address:
    The photosensitizing activity of two multiply charged porphyrazine derivatives, i.e. the Zn(II) species [(CH3)8LZn](8+) and the Zn(II)/Pt(II) heterobimetallic complex [(PtCl2)(CH3)6LZn](6+) (neutralized byI(-) ions; L=tetrakis-2,3-[5,6-di(2-pyridyl)pyrazino]porphyrazinato dianion) has been examined in the water medium in the presence of SDS under experimental conditions in which the two species are present exclusively in their monomeric form. Read More

    Ocular Features in a Case of Nevus of Ota.
    J Coll Physicians Surg Pak 2017 Mar;27(3):S56-S57
    Department of Ophthalmology, Armed Forces Institute of Ophthalmology, Mall Road, Military Hospital, Rawalpindi.
    Oculodermal melanocytosis, also known as Nevus of Ota, is a hamartomatous melanocytic nevus of dermal melanocytes. It presents as a bluish grey patch on the face, which may be congenital or acquired involving the area of distribution of the ophthalmic and maxillary branches of the trigeminal nerve. The nevus can be unilateral or bilateral, and, in addition to skin, it may involve ocular and oral mucosal surfaces. Read More

    Mandibular Reconstruction by Using a Liquid Nitrogen-Treated Autograft in a Dog with an Oral Tumor.
    J Am Anim Hosp Assoc 2017 May/Jun;53(3):167-171. Epub 2017 Mar 14.
    From the Cooperative Department of Veterinary Medicine, Faculty of agriculture, Iwate University, Morioka, Japan (Y.O., J.S., M.G., M.K., Y.U.); the United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan (K.H.); Department of Veterinary Medicine, Faculty of Agriculture, University of Tokyo, Tokyo, Japan (T.M.); and the Department of Orthopaedic Surgery and Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan (H.N., H.T.).
    A 10 yr old intact female German shepherd dog presented with a large peripheral odontogenic fibroma and malignant melanoma on her lower jaw. The tumor was resected with a unilateral subtotal rostral hemimandibulectomy. After the mandible was removed, it was devitalized intraoperatively by freezing it in liquid nitrogen. Read More

    Role of BMI and hormone therapy in melanoma risk: a case-control study.
    J Cancer Res Clin Oncol 2017 Mar 13. Epub 2017 Mar 13.
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy.
    Background: Currently, the association between body mass index (BMI) and hormone therapies and Cutaneous Melanoma (CM) development is strongly debated. This study was carried out to assess the association between BMI, hormone therapies, and CM risk.

    Methods: The present study is a hospital-based case-control study with 605 consecutive CM patients and 592 controls treated for non-neoplastic conditions at the Department of Dermatology in Florence. Read More

    Patient-derived solitary fibrous tumour xenografts predict high sensitivity to doxorubicin/dacarbazine combination confirmed in the clinic and highlight the potential effectiveness of trabectedin or eribulin against this tumour.
    Eur J Cancer 2017 May 8;76:84-92. Epub 2017 Mar 8.
    Molecular Pharmacology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
    Background: Preclinical models that mimic pathological and molecular features of solitary fibrous tumour (SFT) represent an important tool to select effective regimes and novel compounds to be tested in the clinic. This study was aimed at developing two preclinical models of SFT, assessing their predictive value in the clinic and selecting potential novel effective treatments.

    Material And Methods: Two dedifferentiated-SFT (D-SFT) models obtained from patients' biopsies were grown in immunodeficient mice. Read More

    Antitumor activity of orally administered maitake α-glucan by stimulating antitumor immune response in murine tumor.
    PLoS One 2017 9;12(3):e0173621. Epub 2017 Mar 9.
    Department of Microbial Chemistry, Kobe Pharmaceutical University, Kobe, Japan.
    Maitake α-glucan, YM-2A, isolated from Grifola frondosa, has been characterized as a highly α-1,6-branched α-1,4 glucan. YM-2A has been shown to possess an anti-virus effect in mice; however, it does not directly inhibit growth of the virus in vitro, indicating that the anti-virus effect of YM-2A might be associated with modulation of the host immune system. In this study, we found that oral administration of YM-2A could inhibit tumor growth and improve survival rate in two distinct mouse models of colon-26 carcinoma and B16 melanoma. Read More

    Clinical Pharmacokinetics of Vemurafenib.
    Clin Pharmacokinet 2017 Mar 2. Epub 2017 Mar 2.
    Roche Innovation Center New York, 430 East 29th Street, New York, NY, 10016, USA.
    Vemurafenib is an orally administered small-molecule inhibitor of the oncogenic BRAF kinase that is indicated for the treatment of patients with unresectable or metastatic melanoma harbouring BRAF (V600) mutations. Vemurafenib is absorbed rapidly after a single oral dose of 960 mg, reaching maximum drug concentration approximately 4 h after administration. Extensive accumulation occurs after multiple dosing at 960 mg twice daily. Read More

    Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Mucosal Melanomas.
    Head Neck Pathol 2017 Mar 28;11(1):110-117. Epub 2017 Feb 28.
    Department of Pathology, Head and Neck Section, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 085, Houston, TX, 77030, USA.
    The updated edition of The World Health Organization Classification of Tumours of the Head and Neck includes discussions on mucosal melanoma of both the sinonasal and oral cavity. Since the prior edition, sinonasal origin is now recognized as the most common site of occurrence of mucosal melanoma in the head and neck (66%) with oral cavity representing 25% of cases. Histologic features of mucosal melanomas vary widely from spindled, epithelioid, and pleomorphic to rhabdoid, plasmacytoid and undifferentiated. Read More

    Analysis of non-melanoma skin cancer across the tofacitinib rheumatoid arthritis clinical programme.
    Clin Exp Rheumatol 2017 Feb 27. Epub 2017 Feb 27.
    Pfizer Inc, Collegeville, PA, USA.
    Objectives: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We evaluated the incidence of non-melanoma skin cancer (NMSC) across the tofacitinib RA development programme.

    Methods: NMSC events (through August 2013) were identified in patients receiving tofacitinib in two Phase (P)1, eight P2, six P3 and two long-term extension (LTE) studies. Read More

    Outcome and prognostic factors following curative-intent surgery for oral tumours in dogs: 234 cases (2004 to 2014).
    J Small Anim Pract 2017 Mar 22;58(3):146-153. Epub 2017 Feb 22.
    Department of Surgery, Red Bank Veterinary Hospital, Tinton Falls, NJ 07724, USA.
    Objectives: To describe the long-term outcomes and prognostic factors associated with curative-intent surgery for oral tumours in a large series of dogs.

    Methods: Retrospective review of records for dogs with oral tumours treated with curative-intent surgery. Data collected included signalment, weight, surgical procedure, lymph node staging results, computed tomography results, tumour size, histopathology results including margin evaluation, complications, adjunctive therapies, local recurrence or metastasis, date and cause of death and owner satisfaction. Read More

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