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    3483 results match your criteria Oral Malignant Melanoma

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    Clinical investigation of 38 cases of oral mucosal melanoma: A multicentre retrospective analysis in Japan.
    Australas J Dermatol 2017 Aug 15. Epub 2017 Aug 15.
    Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan.
    Background/objectives: The aim of the present study was to investigate treatment modalities and outcomes in oral mucosal melanoma.

    Methods: The clinical and pathological data of 38 consecutive patients with oral mucosal melanoma were retrospectively analyzed. Patients' characteristics were analyzed and overall survival (OS) rates were calculated. Read More

    Safety evaluation of combination carboplatin and toceranib phosphate (Palladia) in tumour-bearing dogs: A phase I dose finding study.
    Vet Comp Oncol 2017 Aug 10. Epub 2017 Aug 10.
    Department of Clinical Sciences, Kansas State University, College of Veterinary Medicine, Manhattan, Kansas.
    Combining conventional cytotoxic maximum tolerated dose (MTD) chemotherapy with low-dose metronomic and/or anti-angiogenic agents is a exciting area of oncologic research. The objective of this study was to establish the MTD, safety and adverse event (AE) profile of 1 such drug combination. This prospective phase I dose-finding clinical trial assumed an open-label 3 + 3 cohort design. Read More

    Characterisation of the cancer-associated glucocorticoid system: key role of 11β-hydroxysteroid dehydrogenase type 2.
    Br J Cancer 2017 Aug 10. Epub 2017 Aug 10.
    Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AD, UK.
    Background: Recent studies have shown that production of cortisol not only takes place in several non-adrenal peripheral tissues such as epithelial cells but, also, the local inter-conversion between cortisone and cortisol is regulated by the 11β-hydroxysteroid dehydrogenases (11β-HSDs). However, little is known about the activity of this non-adrenal glucocorticoid system in cancers.

    Methods: The presence of a functioning glucocorticoid system was assessed in human skin squamous cell carcinoma (SCC) and melanoma and further, in 16 epithelial cell lines from 8 different tissue types using ELISA, western blotting and immunofluorescence. Read More

    Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review.
    Oncol Lett 2017 Aug 2;14(2):1275-1280. Epub 2017 Jun 2.
    Department of Medical Oncology, Oncology Center, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Kingdom of Saudi Arabia.
    Primary oral malignant melanoma is a rare tumor, which is estimated to comprise 0.2-8.0% of all melanoma cases. Read More

    Benefits of marriage on relative and conditional relative cancer survival differ between males and females in the USA.
    J Cancer Surviv 2017 Aug 2. Epub 2017 Aug 2.
    Department of Health Science, College of Life Sciences, Brigham Young University, 2063 Life Sciences Building, Provo, UT, 84604, USA.
    Purpose: The purpose of the paper is to assess the influence of marital status on conditional relative survival of cancer according to sex.

    Methods: Analyses involved 779,978 males and 1,032,868 females diagnosed with 1 of 13 cancer types between 2000 and 2008, and followed through 2013. Data are from the Surveillance, Epidemiology, and End Results (SEER) Program. Read More

    Periodontal Disease and Incident Cancer Risk among Postmenopausal Women: Results from the Women's Health Initiative Observational Cohort.
    Cancer Epidemiol Biomarkers Prev 2017 Aug;26(8):1255-1265
    Department of Epidemiology and Environmental Health, University at Buffalo, State University of New York, Buffalo, New York.
    Background: Periodontal pathogens have been isolated from precancerous and cancerous lesions and also shown to promote a procarcinogenic microenvironment. Few studies have examined periodontal disease as a risk factor for total cancer, and none have focused on older women. We examined whether periodontal disease is associated with incident cancer among postmenopausal women in the Women's Health Initiative Observational Study. Read More

    Feruloylserotonin inhibits hydrogen peroxide-induced melanogenesis and apoptosis in B16F10 and SK-Mel-2 melanoma cells.
    Biochem Biophys Res Commun 2017 Jul 29. Epub 2017 Jul 29.
    Department of Oral Pathology, Dental Science Research Institute and Medical Research Center for Biomineralization Disorders, School of Dentistry, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea. Electronic address:
    Feruloylserotonin (FS) is a major bioactive component of safflower seeds, with documented strong antibacterial, anti-inflammatory, and free radical scavenging activities. Reactive oxygen species (ROS) can strongly induce melanogenesis and cell apoptosis. The present study aimed to investigate the ability of FS in preventing hydrogen peroxide (H2O2)-induced melanogenesis and cell apoptosis. Read More

    Familial Cancers of Head and Neck Region.
    J Clin Diagn Res 2017 Jun 1;11(6):ZE01-ZE06. Epub 2017 Jun 1.
    Reader, Department of Oral Pathology, Krishnadevaraya College of Dental Sciences, Bengaluru, Karnataka, India.
    Cancers that occur in families more often than would be expected by chance are termed as familial cancers. They occur due to an inherited genetic mutation and account for 5%-10% of all cancers. This review article presents some of the common Familial Cancer Syndromes (FCS) such as MEN 2B, hyperparathyroidism-jaw tumour syndrome, familial oral squamous cell carcinoma, melanoma, nasopharyngeal carcinoma, paraganglioma, neurofibroma and other syndromes associated with head and neck region. Read More

    Promoting Oral Therapy Adherence: Consensus Statements From the Faculty of the Melanoma Nursing Initiative on Oral Melanoma Therapies
.
    Clin J Oncol Nurs 2017 Aug;21(4):87-96
    Tennessee Oncology.
    Background: Inhibitors of BRAF and the downstream signaling protein MEK have improved outcomes for patients with BRAF-mutant advanced malignant melanoma. Despite their ease of administration, these oral therapies pose adherence challenges. 
. Read More

    Immunohistochemical Expression of MCAM/CD146 in Canine Melanoma.
    J Comp Pathol 2017 Jul 7;157(1):27-33. Epub 2017 Jun 7.
    Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan; Department of Veterinary Pathology, Faculty of Veterinary Medicine, Kafr ElSheikh University, Egypt. Electronic address:
    MCAM/CD146 (melanoma cell adhesion molecule/CD146) is a transmembrane immunoglobulin superfamily cell adhesion molecule involved in transendothelial migration and signal transduction. It is expressed in melanoma, squamous cell carcinoma, prostatic, ovarian, cervical and endometrial cancers and promotes tumour growth, angiogenesis and metastasis. Melanoma is the most common malignant oral tumour of dogs and also arises in the skin, nail bed and footpad. Read More

    Implementation of a model-based design in a phase 1b study of combined targeted agents.
    Clin Cancer Res 2017 Jul 21. Epub 2017 Jul 21.
    Public Health Sciences, University of Virginia.
    In recent years, investigators have recognized the rigidity of single agent, safety only, traditional designs, rendering them ineffective for conducting contemporary early-phase clinical trials, such as those involving combinations and /or biological agents.  Novel approaches are required to address these research questions, such as those posed in trials involving targeted therapies. We describe the implementation of a model-based design for identifying an optimal treatment combination, defined by low toxicity and high efficacy, in an early-phase trial evaluating a combination of two oral targeted inhibitors in relapsed / refractory mantle cell lymphoma. Read More

    AIM2 Inflammasome-Mediated Pyroptosis in Enterovirus A71-Infected Neuronal Cells Restricts Viral Replication.
    Sci Rep 2017 Jul 19;7(1):5845. Epub 2017 Jul 19.
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
    Encephalomyelitis is a well-known complication of hand, foot, and mouth disease (HFMD) due to Enterovirus 71 (EV71) infection. Viral RNA/antigens could be detected in the central nervous system (CNS) neurons in fatal encephalomyelitis but the mechanisms of neuronal cell death is not clearly understood. We investigated the role of absent in melanoma 2 (AIM2) inflammasome in neuronal cell death, and its relationship to viral replication. Read More

    A first-in-human phase I, multicenter, open-label, dose-escalation study of the oral RAF/VEGFR-2 inhibitor (RAF265) in locally advanced or metastatic melanoma independent from BRAF mutation status.
    Cancer Med 2017 Aug 18;6(8):1904-1914. Epub 2017 Jul 18.
    Beth Israel Deaconess Medical Center, Boston, Massachusetts.
    To establish the maximum tolerated dose (MTD), dose-limiting toxicities (DLT), safety profile, and anti-tumor efficacy of RAF265. We conducted a multicenter, open-label, phase-I, dose-escalation trial of RAF265, an orally available RAF kinase/VEGFR-2 inhibitor, in patients with advanced or metastatic melanoma. Pharmacokinetic (PK) analysis, pharmacodynamics (PD) and tumor response assessment were conducted. Read More

    Zebrafish as a Model Organism for the Development of Drugs for Skin Cancer.
    Int J Mol Sci 2017 Jul 18;18(7). Epub 2017 Jul 18.
    Faculty of Medicine and Life Sciences, University of Tampere, 33014 Tampere, Finland.
    Skin cancer, which includes melanoma and squamous cell carcinoma, represents the most common type of cutaneous malignancy worldwide, and its incidence is expected to rise in the near future. This condition derives from acquired genetic dysregulation of signaling pathways involved in the proliferation and apoptosis of skin cells. The development of animal models has allowed a better understanding of these pathomechanisms, with the possibility of carrying out toxicological screening and drug development. Read More

    Risk of Second Primary Malignancies in Patients With Follicular Lymphoma: A United States Population-based Study.
    Clin Lymphoma Myeloma Leuk 2017 Jun 24. Epub 2017 Jun 24.
    Division of Hematology-Oncology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE.
    Background: With the improving outcomes of patients with follicular lymphoma (FL), it is imperative to focus on survivorship issues, including the development of second primary malignancies (SPMs). We used a large US database to measure the risk of SPMs among FL survivors.

    Materials And Methods: We used the Surveillance, Epidemiology, and End Results-13 registry to identify FL patients from 1992 to 2011. Read More

    Margin Analysis: Cutaneous Malignancy of the Head and Neck.
    Oral Maxillofac Surg Clin North Am 2017 Aug;29(3):341-353
    Department of Pathology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA.
    This article focuses only on margin analysis of the cutaneous malignancy of the skin. It discusses basal cell carcinoma, squamous cell carcinoma, and cutaneous melanoma. The management of the neck and distant disease are beyond the scope of this article, but it answers what is the appropriate surgical margin when excising these skin tumors, whether frozen sections are accurate for the analysis of these tumors, and treatment algorithm and rationale for a positive resection margin. Read More

    Supportive care for patients undergoing immunotherapy.
    Support Care Cancer 2017 Jul 13. Epub 2017 Jul 13.
    University of the Witwatersrand and Wits Donald Gordon Medical Center, Johannesburg, South Africa.
    Immune checkpoint inhibitors, a new class of cancer therapeutic agents, play an important role in the management of melanoma, NSCLC, and other malignancies. A workshop organized by three MASCC Study Groups: Oral Care, Skin Toxicities, and Neutropenia, Infection, and Myelosuppression during the MASCC Annual Meeting held in Adelaide, Australia on 23-25 June, 2016 focused on the new class of anti-cancer therapeutic agents. Topics in the workshop included the mechanism of action and clinical uses of immune anti-CTL4 and anti-PD1 antibodies, checkpoint inhibitor toxicities, including skin adverse events, gastrointestinal toxicities, oral complications, pulmonary toxicities, and endocrinological and immune-related infections. Read More

    Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo.
    Arterioscler Thromb Vasc Biol 2017 Jul 13. Epub 2017 Jul 13.
    From the Division of Cardiovascular Medicine, Department of Internal Medicine (T.H., T.M., K.M., T.O., M.O., T.I., K.-i.H.), Division of Cell Biology, Department of Physiology and Cell Biology (N.I., M.A., M.F.), Department of Oral and Maxillofacial Surgery (M.A.), Division of Evidence-Based Laboratory Medicine (R.T., Y.I.), Division of Integrated Medical Education, Department of Community Medicine and Social Healthcare Science (M.S.), and The Integrated Center for Mass Spectrometry (M.S.), Kobe University Graduate School of Medicine, Japan; Animal Resource Development Unit (Y.Y.) and Genetic Engineering Team (Y.Y., G.S.), RIKEN Center for Life Science Technologies, Kobe, Hyogo, Japan; and Division of Cerebral Structure, National Institute for Physiological Sciences, Okazaki, Aichi, Japan (M.F.).
    Objective: Recent genome-wide association studies newly identified the human KIAA1462 gene as a new locus for coronary artery disease. However, the function of the gene product, named JCAD (junctional protein associated with coronary artery disease), is unknown. Because JCAD is expressed at cell-cell junctions in endothelial cells, we hypothesized and tested whether JCAD regulates angiogenic processes in vitro and in vivo. Read More

    Familial melanoma-astrocytoma syndrome: synchronous diffuse astrocytoma and pleomorphic xanthoastrocytoma in a patient with germline CDKN2A/B deletion and a significant family history.
    Clin Neuropathol 2017 Jul 12. Epub 2017 Jul 12.
    Familial melanoma-astrocytoma syndrome is a tumor predisposition syndrome caused by inactivating germline alteration of the CDKN2A tumor suppressor gene on chromosome 9p21. While some families with germline CDKN2A mutations are prone to development of just melanomas, other families develop both melanomas, astrocytomas, and occasionally other nervous-system neoplasms including peripheral nerve sheath tumors and meningiomas. The histologic spectrum of the astrocytomas that arise as part of this syndrome is not well described, nor are the additional genetic alterations that drive these astrocytomas apart from the germline CDKN2A inactivation. Read More

    The use of lasers in the treatment of skin cancer: A review.
    J Cosmet Laser Ther 2017 Jul 10:1-8. Epub 2017 Jul 10.
    c Skin and Laser Surgery Center of New England , Nashua , NH , USA.
    Background: In considering skin cancer, a number of factors-including effectiveness, simplicity of treatment, cost, and esthetic outcomes-are important to ensure patient's satisfaction. There are several existing interventions, such as electrodessication and curettage, excision, Mohs surgery, radiation therapy, cryotherapy, and topical/oral treatments. Laser therapy has emerged as a new promising alternative that should be explored. Read More

    Oral melanoma with osteocartilagineous differentiation: a case report and literature review.
    J Biol Regul Homeost Agents 2017 Apr-Jun;31(2 Suppl 1):147-154
    Maxillofacial and Dental Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy.
    Osteocartilagineous differentiation within malignant melanoma is a rare occurrence with several implications for diagnosis. Most of the reported cases have occurred in acral lentiginous malignant melanomas. In this paper, the authors describe the clinical, morphological, immunohistochemical features and surgical treatment of a case of primary oral mucosal melanoma with osteocartilaginous differentiation and they review the existing literature. Read More

    Menopausal hormone therapy and risk of melanoma: Do estrogens and progestins have a different role?
    Int J Cancer 2017 Jul 7. Epub 2017 Jul 7.
    Department of Research, Cancer Registry of Norway, Oslo University Hospital, Oslo, Norway.
    The association between use of menopausal hormone therapy (HT) and occurrence of skin malignant melanoma (SMM) is controversial. We investigated the issue in a nationwide cohort of 684,696 Norwegian women, aged 45-79 years, followed from 2004 to 2008. The study was based on linkage between Norwegian population registries. Read More

    Melanoma patients' disease-specific knowledge, information preference, and appreciation of educational YouTube videos for self-inspection.
    Eur J Surg Oncol 2017 Aug 24;43(8):1528-1535. Epub 2017 Jun 24.
    University of Groningen, University Medical Center Groningen, Department of Surgical Oncology, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. Electronic address:
    Background: Informing and educating melanoma patients is important for early detection of a recurrence or second primary. This study aimed to investigate Dutch melanoma patients' disease-specific knowledge, and their opinions on information provision and the value of e-Health videos.

    Methods: All AJCC stage I-II melanoma patients in follow-up between March 2015 and March 2016 at a single melanoma center were invited to complete 19 online questions, addressing respondents' characteristics, knowledge on melanoma, and opinions on melanoma-specific information received and the educational YouTube videos. Read More

    Positron Emission Tomography in Mucosal Melanomas of Head and Neck: Results from a South Asian Tertiary Cancer Care Center.
    World J Nucl Med 2017 Jul-Sep;16(3):197-201
    Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra, India.
    To evaluate the accuracy of fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in staging and restaging of patients with mucosal melanomas (MM) of head and neck. Patients who underwent PET/CT at our institution, with a biopsy proven diagnosis of MM of the head and neck between March 2006 and December 2013 were included in the study. Nineteen patients with MM of the nasal cavity, paranasal sinuses, and oral cavity were included, of which 12 were for staging and seven for restaging. Read More

    Multiple Oral Deep Penetrating Nevi Extending to the Masseter and Buccal Fat Pad.
    J Oral Maxillofac Surg 2017 Jun 1. Epub 2017 Jun 1.
    Associate Professor, Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry, Seoul, Korea. Electronic address:
    The deep penetrating nevus (DPN) is a rare benign melanocytic tumor often clinically and histopathologically mistaken for malignant melanoma (MM) and other nevus types. This report describes an extremely rare case of multiple lesions of a large DPN in the oral cavity with extensive infiltration to the minor salivary gland, buccal fat pad, buccinators, and masseter muscles, yet with preservation of the normal anatomic architecture. After receiving a diagnosis of MM in another hospital, the patient was at risk for receiving a wide excision that included the masticatory muscles, facial nerve, and overlying skin. Read More

    Melanoma Metastasis to the Mandible-Case Report and Comprehensive Literature Review.
    J Oral Maxillofac Surg 2017 Jun 1. Epub 2017 Jun 1.
    Certified by the American Board of Oral and Maxillofacial Pathology; Practicing in Department of Oral and Maxillofacial Pathology, Naval Postgraduate Dental School, Bethesda, MD.
    With the incidence of melanoma increasing yearly, there is a need for heightened awareness of its metastatic potential and for screening with appropriate referral for identification of pre-metastatic lesions. Melanoma has a 16- to 25-month period to metastasize from a localized disease to one with a median survival no longer than 12 months once metastasis occurs. Nearly one third of oral metastases are found to be the first indication of occult malignancy from a distant site. Read More

    Activation of IRF3 contributes to IFN-γ and ISG54 expression during the immune responses to B16F10 tumor growth.
    Int Immunopharmacol 2017 Sep 23;50:121-129. Epub 2017 Jun 23.
    Nebraska Center for Virology, University of Nebraska-Lincoln, United States; Department of Oral Biology, University of Nebraska Medical Center, Lincoln, NE, United States. Electronic address:
    Interferon Regulatory Factor (IRF-3) has been shown to contribute to immune control of B16 melanoma tumor growth. We have shown previously that IRF-3 has a role in IFN-γ-induced expression of pro-apoptotic interferon stimulated gene 54 (ISG54) in macrophages and IFN-γ in T cells. To investigate the IRF3-IFN-γ-ISG54 nexus, we injected C57Bl/6 (B6) and IRF3KO mice s. Read More

    A Review of the Aetiopathogenesis and Clinical and Histopathological Features of Oral Mucosal Melanoma.
    ScientificWorldJournal 2017 30;2017:9189812. Epub 2017 May 30.
    Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Medunsa, Pretoria 0204, South Africa.
    Oral mucosal melanoma is an uncommon, usually heavily melanin-pigmented, but occasionally amelanotic aggressive tumour with a poor prognosis. Despite radical surgery, radiotherapy, or chemotherapy, local recurrence and distant metastasis are frequent. Microscopical examination is essential for diagnosis, and routine histological staining must be supplemented by immunohistochemical studies. Read More

    Rapid ex vivo examination of Mohs specimens using optical coherence tomography.
    Photodiagnosis Photodyn Ther 2017 Jun 12. Epub 2017 Jun 12.
    Department of Dermatology, University College Hospitals, London, UK.
    Background: Mohs micrographic surgery (MMS) is an effective treatment for certain non-melanoma skin cancers. Optical coherence tomography (OCT) is a biomedical imaging modality that permits high-resolution imaging of the epidermis and dermis with the potential to detect both healthy tissue and tumour. OCT may also provide a means of detecting and differentiating between the various histological subtypes of basal cell carcinomas (BCC) in vivo. Read More

    Genome-wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus.
    Arthritis Res Ther 2017 Jun 15;19(1):138. Epub 2017 Jun 15.
    Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, 08035, Spain.
    Background: Systemic lupus erythematosus (SLE) is a genetically complex rheumatic disease characterized by heterogeneous clinical manifestations of unknown etiology. Recent studies have suggested the existence of a genetic basis for SLE heterogeneity. The objective of the present study was to identify new genetic variation associated with the clinically relevant phenotypes in SLE. Read More

    Microwave-Assisted Facile Synthesis, Anticancer Evaluation and Docking Study of N-((5-(Substituted methylene amino)-1,3,4-thiadiazol-2-yl)methyl) Benzamide Derivatives.
    Molecules 2017 Jun 15;22(6). Epub 2017 Jun 15.
    Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Maharashtra, Aurangabad 431001, India.
    In the present work, 12 novel Schiff's bases containing a thiadiazole scaffold and benzamide groups coupled through appropriate pharmacophore were synthesized. These moieties are associated with important biological properties. A facile, solvent-free synthesis of a series of novel 7(a-l) N-((5-(substituted methylene amino)-1,3,4-thiadiazol-2-yl)methyl) benzamide was carried out under microwave irradiation. Read More

    Visual Loss from Choroidal Melanoma Mimicking Neurological Syndromes.
    Case Rep Neurol 2017 Jan-Apr;9(1):31-35. Epub 2017 Mar 20.
    aOcular Oncology Service, Moorfields Eye Hospital and St. Bartholomew's Hospital, London, UK.
    Melanoma of the eye is rare, but can mimic a range of disorders. This report highlights 2 cases of choroidal melanoma with vision loss mimicking neurological diagnoses. The first patient is a 41-year-old white male with a known history of multiple sclerosis and a previous episode of optic neuritis in the right eye, who presented with a 6-month history of decreased vision in the same eye, and occasional photopsiae. Read More

    Prognostic significance of cyclooxygenase 2 and phosphorylated Akt1 overexpression in primary nonmetastatic and metastatic cutaneous melanomas.
    Melanoma Res 2017 Jun 9. Epub 2017 Jun 9.
    aUnit of Oral Pathology, Department of Oral Diagnosis, Piracicaba Dental School bDepartment of Pathology, Medical Sciences School, University of Campinas, Campinas, Brazil.
    Cyclooxygenase 2 (COX-2) and phosphorylated Akt1 (p-Akt1) are associated with tumor spreading, cell proliferation, high metabolism, and angiogenesis in solid tumors. This study aimed to investigate COX-2 and p-Akt1 expression in primary and metastatic melanomas by correlating with the cellular proliferation index (as revealed by minichromosome maintenance 2 expression) and the outcome of patients with malignant melanomas. Seventy-seven biopsies of malignant melanomas, including 42 primary nonmetastatic melanomas (PNMMs), 12 primary metastatic melanomas (PMMs), and 23 metastatic melanomas (MMs), were retrospectively selected. Read More

    Varied immuno-related adverse events induced by immune-check point inhibitors - Nivolumab-associated psoriasiform dermatitis related with increased serum level of interleukin-6.
    Nihon Rinsho Meneki Gakkai Kaishi 2017 ;40(2):95-101
    Department of Dermatology, Faculty of Medicine, University of Tsukuba.
      Nivolumab is a standard recombinant antibody treatment for patients with malignant melanoma (MM), which functions as an immune checkpoint inhibitor by blocking the programmed cell death-1 (PD-1) pathway in T cells. However, it leads to various immune-related adverse events (irAEs), and also exacerbates underlying autoimmune diseases. Herein we report cases of MM with irAE. Read More

    Dabrafenib plus trametinib in patients with BRAF(V600)-mutant melanoma brain metastases (COMBI-MB): a multicentre, multicohort, open-label, phase 2 trial.
    Lancet Oncol 2017 Jul 4;18(7):863-873. Epub 2017 Jun 4.
    Melanoma Institute Australia, The University of Sydney, Royal North Shore and Mater Hospitals, Sydney, NSW, Australia.
    Background: Dabrafenib plus trametinib improves clinical outcomes in BRAF(V600)-mutant metastatic melanoma without brain metastases; however, the activity of dabrafenib plus trametinib has not been studied in active melanoma brain metastases. Here, we report results from the phase 2 COMBI-MB trial. Our aim was to build on the current body of evidence of targeted therapy in melanoma brain metastases through an evaluation of dabrafenib plus trametinib in patients with BRAF(V600)-mutant melanoma brain metastases. Read More

    A Rare Case of Malignant Melanoma of the Mandible: 
CT and MRI Findings.
    Chin J Dent Res 2017 ;20(2):111-114
    Malignant melanoma of the mandibular gingiva is extremely rare. It is a malignant tumour of melanocytes or their precursor cells, and often misinterpreted as a benign pigmented process. A few reports have described computed tomography (CT) and magnetic resonance imaging (MRI) findings of malignant melanoma in the oral cavity. Read More

    Non-pulmonary cancer risk following tuberculosis: a nationwide retrospective cohort study in Lithuania.
    Infect Agent Cancer 2017 31;12:33. Epub 2017 May 31.
    Department of Thoracic Surgery and Oncology, National Cancer Institute, Santariskiu g. 1, LT-08660 Vilnius, Lithuania.
    Background: Lithuania remains one of the highest tuberculosis burden countries in Europe. Epidemiological studies have long pointed to infections as important factors of cancer aetiology, but the association between tuberculosis and the risk of non-pulmonary cancers has rarely been tested and results have been inconsistent. The aim of this population-based cohort study was to examine the risk of cancer among patients diagnosed with tuberculosis using data from Lithuanian Tuberculosis, Cancer and Resident's Registries. Read More

    Successful Treatment of Sudden Hepatitis Induced by Long-Term Nivolumab Administration.
    Case Rep Oncol 2017 Jan-Apr;10(1):368-371. Epub 2017 Apr 24.
    bDepartment of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Immune checkpoint inhibitors have drastically changed in the treatment of many kinds of malignancies, especially malignant melanoma. The focus of the recent experiments has not only been on their efficacy but also immune-related adverse events (irAEs). We report a case of fulminant hepatitis due to nivolumab. Read More

    An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin.
    Angew Chem Int Ed Engl 2017 Jul 26;56(28):8267-8271. Epub 2017 May 26.
    Institut für Analytische Chemie, Universität Wien, Währinger Strasse 38, 1090, Wien, Austria.
    Organometallic metal(arene) anticancer agents require ligand exchange for their anticancer activity and this is generally believed to confer low selectivity for potential cellular targets. However, using an integrated proteomics-based target-response profiling approach as a potent hypothesis-generating procedure, we found an unexpected target selectivity of a ruthenium(arene) pyridinecarbothioamide (plecstatin) for plectin, a scaffold protein and cytolinker, which was validated in a plectin knock-out model in vitro. Plectin targeting shows potential as a strategy to inhibit tumor invasiveness as shown in cultured tumor spheroids while oral administration of plecstatin-1 to mice reduces tumor growth more efficiently in the invasive B16 melanoma than in the CT26 colon tumor model. Read More

    Usefulness of (11)C-methionine-PET for predicting the efficacy of carbon ion radiation therapy for head and neck mucosal malignant melanoma.
    Int J Oral Maxillofac Surg 2017 May 20. Epub 2017 May 20.
    Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine, Tsurumi, Yokohama, Japan.
    The aim of this study was to determine whether l-methyl-[(11)C]-methionine (MET) positron emission tomography (PET) allows the prediction of outcomes in patients with head and neck mucosal malignant melanoma treated with carbon ion radiation therapy (CIRT). This was a retrospective cohort study involving 85 patients who underwent a MET-PET or MET-PET/computed tomography (CT) examination before and after CIRT. MET uptake in the tumour was evaluated semi-quantitatively using the tumour-to-normal tissue ratio (TNR). Read More

    Comparison of SPECT/CT and Planar Lympho-scintigraphy in Sentinel Node Biopsies of Oral Cavity Squamous Cell Carcinomas.
    Indian J Nucl Med 2017 Apr-Jun;32(2):98-102
    Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, E. Borges Road, Parel, Mumbai, India.
    Introduction: Evidence supporting the use of Sentinel node biopsy (SNB) for nodal staging of early oral squamous cell carcinomas (OSCC) appears to be very promising. Pre-operative lymphatic mapping using planar lymphoscinitigraphy (PL) with or without SPECT/CT in the SNB procedure is useful in sentinel node localization and for planning appropriate surgery. Recently, a large prospective multi-centric study evaluating SNB in cutaneous melanoma, breast and pelvic malignancies, demonstrated that adding SPECT to PL leads to surgical adjustments in a considerable number of patients. Read More

    INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology.
    ACS Med Chem Lett 2017 May 6;8(5):486-491. Epub 2017 Mar 6.
    Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803, United States.
    A data-centric medicinal chemistry approach led to the invention of a potent and selective IDO1 inhibitor 4f, INCB24360 (epacadostat). The molecular structure of INCB24360 contains several previously unknown or underutilized functional groups in drug substances, including a hydroxyamidine, furazan, bromide, and sulfamide. These moieties taken together in a single structure afford a compound that falls outside of "drug-like" space. Read More

    Two Cases of Nivolumab Re-Administration after Pneumonitis as Immune-Related Adverse Events.
    Case Rep Oncol 2017 Jan-Apr;10(1):296-300. Epub 2017 Apr 4.
    bDepartment of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Nivolumab is a recently approved medication for the treatment of unresectable malignant melanoma. Many immune-related adverse events (irAEs) associated with nivolumab have been reported, such as pneumonitis, hepatitis, dermatitis, and thyroiditis. Prednisolone can effectively treat irAEs. Read More

    Antibiotics-induced gut microbiota dysbiosis promotes tumor initiation via affecting APC-Th1 development in mice.
    Biochem Biophys Res Commun 2017 Jun 12;488(2):418-424. Epub 2017 May 12.
    State Key Laboratory of Cancer Biology, Department of Pharmacogenomics, Fourth Military Medical University, Xi'an 710032, PR China. Electronic address:
    Gut microbiota is critical for maintaining body immune homeostasis and thus affects tumor growth and therapeutic efficiency. Here, we investigated the link between microbiota and tumorgenesis in a mice model of subcutaneous melanoma cell transplantation, and explored the underlying mechanism. We found disruption of gut microbiota by pretreating mice with antibiotics promote tumor growth and remodeling the immune compartment within the primary tumor. Read More

    Anti-tumor effects of differentiation-inducing factor-1 in malignant melanoma: GSK-3-mediated inhibition of cell proliferation and GSK-3-independent suppression of cell migration and invasion.
    Biochem Pharmacol 2017 Aug 10;138:31-48. Epub 2017 May 10.
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
    Differentiation-inducing factor-1 (DIF-1) isolated from Dictyostelium discoideum strongly inhibits the proliferation of various mammalian cells through the activation of glycogen synthase kinase-3 (GSK-3). To evaluate DIF-1 as a novel anti-cancer agent for malignant melanoma, we examined whether DIF-1 has anti-proliferative, anti-migratory, and anti-invasive effects on melanoma cells using in vitro and in vivo systems. DIF-1 reduced the expression levels of cyclin D1 and c-Myc by facilitating their degradation via GSK-3 in mouse (B16BL6) and human (A2058) malignant melanoma cells, and thereby strongly inhibited their proliferation. Read More

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